UCSF Lab Standard Operating Procedure Chemical Process, Name or Hazard Class: Haloperidol Please fill out the form completely. Insure all users have access to this SOP. Refer to instructions for assistance. Enter text. Department: Date SOP was written: Enter date. This lab specific SOP has been reviewed and approved by: Principal Investigator Name: Enter text. Principal Investigator Signature Lab Manager/Supervisor: Type of SOP: ☐ Process Enter text. ☒Hazardous Chemical ☐ Hazardous Class Purpose Haloperidol is toxic if ingested and may be harmful if inhaled or absorbed through the skin. It causes irritation to the gastrointestinal tract, respiratory tract, skin, and eyes. It is a suspected reproductive toxicant. Haloperidol is a butyrophenone antipsychotic and a dopamine receptor antagonist. It is used to treat certain mental disorders such as schizophrenia. Physical & Chemical Properties/Definition of Chemical Group CAS#: 52-86-8 Class: Target organ effect, toxic by ingestion, skin sensitizer, irritant, reproductive toxin Molecular Formula: C21H23ClFNO2 Form (physical state): Solid Color: White Boiling point: Decomposes Potential Hazards/Toxicity Haloperidol 1 Date: Click here to enter a date. Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/) Haloperidol is toxic if ingested and may be harmful if inhaled or absorbed through the skin. It causes irritation to the respiratory tract, gastrointestinal tract, skin, and eyes. It may cause an allergic skin reaction. It may damage fertility or the unborn child. Symptoms of exposure include dizziness, drowsiness, sleep disturbances, headache, anxiety, muscle spasm, tremor, nausea, vomiting, abdominal pain, and allergy. It may have adverse effects on the central nervous system, blood, eyes, liver, and cardiovascular system. Engineering Controls Chemical fume hood. Adequate exhaust and capture filtration. Personal Protective Equipment (PPE) Respirator Protection If lab personnel would like to use respirator on a voluntary basis, they must be trained and fit-tested by EH&S. This is a regulatory requirement. (http://or.ucsf.edu/ehs/8193-DSY/version/default/part/4/data/) Hand Protection Handle with gloves. Nitrile gloves are recommended. NOTE: Consult with your preferred glove manufacturer to ensure that the gloves you plan on using are compatible with haloperidol. Refer to glove selection chart from the links below: http://www.ansellpro.com/download/Ansell_8thEditionChemicalResistanceGuide.pdf OR http://www.allsafetyproducts.biz/page/74172 OR http://www.showabestglove.com/site/default.aspx OR http://www.mapaglove.com/ Eye Protection ANSI approved, tight-fitting glasses/goggles. Face shields are recommended. Skin and Body Protection Appropriately-fitting lab coat, long pants, closed-toe shoes. Hygiene Measures Avoid contact with skin, eyes, and clothing. Wash hands before breaks and after handling. First Aid Procedures If inhaled Move person into fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Consult a physician. In case of skin contact Flush with plenty of water for at least 15 minutes while removing contaminated clothing. Consult a physician. Take victim immediately to the hospital. In case of eye contact Haloperidol 2 Date: Click here to enter a date. Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/) Flush eyes with plenty of water for at least 15 minutes lifting upper and lower eyelids and removing contact lenses. Consult a physician. If swallowed Do not induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Special Handling and Storage Requirements Precautions for safe handling: Avoid contact with skin, eyes, and clothing. Avoid inhalation and ingestion. Avoid dust formation. Provide adequate exhaust ventilation. Ensure normal measures for preventative fire protection. Conditions for safe storage: Keep container tightly closed in a cool, dry, and well-ventilated area. Avoid strong oxidizing agents. Spill and Accident Procedure Chemical Spill Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-2068522 (SFGH only) Spill – Assess the extent of danger. Assist contaminated or injured persons. Evacuate the spill area. Avoid breathing vapors. If possible, confine the spill to a small area using a spill kit or absorbent material. Keep others from entering contaminated area (e.g., use caution tape, barriers, etc.). Small (<1 L) – If you have training, you may assist in the clean-up effort. Use appropriate personal protective equipment and clean-up material for chemical spilled. Double bag spill waste in clear plastic bags, label and take to the next chemical waste pick-up. Large (>1 L) – Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-2068522 (SFGH only) for assistance. Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in emergency shower for at least 15 minutes. If discomfort persists, proceed to the Emergency Department. If no further discomfort is experienced, have the SDS ready and contact Poison Control Hotline at 1-800222-1222 for further exposure information. Notify your direct supervisor and EH&S at 415-4761300 during work hours, or 9-911 during non-working hours and weekends. Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with water for 15 minutes by forcibly holding the eye open. If discomfort persists, proceed to the Emergency Department. If no further discomfort is experienced, have the SDS ready and contact Poison Control Hotline at 1-800-222-1222 for further exposure information. Notify your direct supervisor and EH&S at 415-476-1300 during work hours, or 9-911 during non-working hours and weekends. Medical Emergency Dial 9-911 (campus phone) or 476-6911 (cell phone) Haloperidol 3 Date: Click here to enter a date. Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/) Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours. Non-Life Threatening Emergency– Go to Occupational Health Programs (OHP) Clinic, 415-8857580, 2330 Post Street, Suite 460 Hours of Operation for Appointments: Monday - Friday 7:30 a.m. - 4:00 p.m. (except Holidays). Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours. Needle stick/puncture exposure (as applicable to chemical handling procedure) – Wash the affected area with antiseptic soap and warm water for 15 minutes. For mucous membrane exposure, flush the affected area for 15 minutes using an eyewash station. Page the needle stick nurse by dialing 415-353-7842 (STIC). Decontamination/Waste Disposal Procedure Clean contaminated surfaces with soap and water and paper towels. Dispose of the paper towels as hazardous waste. Safety Data Sheet (SDS) Location Online SDS can be accessed at http://or.ucsf.edu/ehs/7241-DSY/msds.html Protocol/Procedure Quantities covered by this SOP: ______ (g , ml) to _______ (g, ml) Temperature range covered by this SOP: __ °C – __ °C General Overview and Purpose: Enter the experimental purpose Procedure: Enter experimental procedure. You can copy procedure from your lab notebook or from literature. NOTE Any deviation from this SOP requires approval from the Principal Investigator. Haloperidol 4 Date: Click here to enter a date. Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)