Program Director/Principal Investigator (Last, First, Middle):
BIOGRAPHICAL SKETCH
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NAME
POSITION TITLE
Barthel, Kristen Bjorkman
Post-doctoral research assistant
eRA COMMONS USER NAME (credential, e.g., agency login)
KRISTENBJORKMAN
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
St. Olaf College Northfield, MN
University of Colorado Boulder, CO
University of Colorado Boulder, CO
DEGREE
(if applicable)
B.A.
Ph.D.
Post-doc
YEAR(s)
2001
2007
FIELD OF STUDY
Chemistry, French
Biochemistry
Molecular Biology
A. Personal Statement. As a post-doctoral research fellow in the Leinwand Lab, my research focuses on
muscle-specific miRNAs (“myomiRs”) and how they participate in the regeneration of injured skeletal
muscle in both male and female animals. In particular I am interested in how they may contribute to the
observed differences in regeneration between the sexes and whether there is an underlying hormonal
component. To study this problem, I measure miRNA levels along a regeneration timecourse and compare
levels in animals with different hormonal statuses. I have also defined a transcriptional enhancer controlling
the expression of a particular myomiR and am investigating whether it is hormone-responsive. My
background has thoroughly prepared me for this line of research. In graduate school, I published several
papers describing aspects of transcriptional regulation in muscle cells in vitro, both from the perspective of
DNA features controlling muscle-specific gene expression and the regulation of the transcription factors
coordinating this expression. I also performed many assays to look at steady-state levels of a variety of
mRNAs, and I easily extended these tecniques to miRNAs and their mRNA targets. Finally, I have a long
history of working collaboratively on projects, as my publication record can attest to, and of working with
undergraduate and new graduate students.
B. Positions and Honors.
Positions
2001-2007 Graduate Student, Department of Chemistry and Biochemistry, University of Colorado, Boulder,
CO
2007-2008 Postdoctoral Assistant, Department of Chemistry and Biochemistry, University of Colorado,
Boulder, CO
2008Postdoctoral Assistant, MCD Biology Department, University of Colorado, Boulder, CO
Honors
1997-2001 St. Olaf Presidential Scholarship
1997-2001 National Merit Scholar
1997-2001 Dow Chemical Award recipient
1997-2005 Marshall H. and Nellie Alworth Memorial Scholarship
2001
Pi Delta Phi (national French honor society) inductee
2001
Phi Lambda Upsilon (national Chemistry honor society) inductee
2001
Phi Beta Kappa inductee
2001
Summa cum laude graduate
2002
Graduate Teaching Excellence Award
2002-2005 NIH Predoctoral Training Grant recipient
2008NIH Postdoctoral Training Grant recipient
PHS 398/2590 (Rev. 11/07)
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Biographical Sketch Format Page
PI Name
C. Selected peer-reviewed publications (in chronological order).
Program Director/Principal Investigator (Last, First, Middle):
1. Barthel, K.K., and X. Liu (2008). A transcriptional enhancer from the coding region of ADAMTS5. PLoS
ONE 3:e2184. PMID: 18478108.
2. Bates, D.L., Barthel, K.K., Wu, Y., Kalhor, R., Stroud, J.C., Giffin, M.J., and L. Chen (2008). Crystal
3.
4.
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6.
structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element. Structure 16:684-694.
PMID: 18462673.
Cheung, T.H.*, Barthel, K.K.*, Kwan, Y.L., and X. Liu (2007). Identifying pattern-defined regulatory islands
in mammalian genomes. Proc Natl Acad Sci U S A 104:10116-10121. PMID: 17535887.
Riquelme, C.*, Barthel, K.K.*, and X. Liu (2006) SUMO-1 modification of MEF2A regulates its
transcriptional activity. J Cell Mol Med 10:132-144. PMID: 16563226.
Riquelme, C.*, Barthel, K.K.*, Qin, X.F., and X. Liu (2006) Ubc9 expression is essential for myotube
formation in C2C12. Exp Cell Res 312:2132-41. PMID: 16631162.
Knuesel, M., Cheung, H.T., Hamady, M., Barthel, K.K., and X. Liu (2005). A method of mapping protein
sumoylation sites by mass spectrometry using a modified small ubiquitin-like modifier 1 (SUMO-1) and a
computational program. Mol Cell Proteomics 4:1626-1636. PMID: 16020427.
* These authors contributed equally.
D. Research Support.
PHS 398/2590 (Rev. 11/07)
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