"Protein Design with the Molecular Modeling Software Rosetta"
An overview will be given of Rosetta's protein design capabilities. These include
methods for stabilizing proteins, increasing protein-protein binding affinities, design
of novel protein interactions, de novo design of protein structure and enzyme
design. Critical to many of these protocols is the simultaneous sampling of protein
conformational space and sequence space. In this way it is possible search for
conformations and docked positions that are intrinsically more designable. Rosetta
methods for sampling conformational and sequence space will be discussed as well as
the key features of its energy function.