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ÿÿþ ÿÿà % ÿÿÿ€ÿÿÿø / ?ÿÿÿãÿÿÿþ ÿÿÿÿÿÿÿÿ ÿ€ ÿÿÿÿÿÿÿÿÿà ÿÿÿÿÿÿÿ ÿÿÿÿø ÿÿÿÿ ÿÿÿÿÿÿà ÿø ÿÿÿ€ÿð ÿÿÿÿÿÿÿà ÿÿÿÿø ÿÿÿÿ ÿÿÿÿÿÿü 2 ÿ€ ÿø ÿü ÿÿÿÿÿÿÿü ÿÿÿÿø ÿÿÿÿÿÿÿÿÿÿÿ€ 2 þ ÿà ?þ ÿÿÿÿÿÿÿÿ ÿÿÿÿø ÿÿÿÿ ÿÿÿÿÿÿÿà > ?ø ÿð ÿ ÿÿÿÿÿÿÿÿ€ÿÿ ÿÿø ÿÿÿÿ ÿÿÿÿÿÿÿø 8 •à ÿø ÿ€ ÿÿÿÿÿÿÿÿà ÿÿÿÿø ÿÿÿÿ ÿÿÿÿÿÿÿþ 8 ÿà ÿü ÿÀ ÿÿÿÿÿÿÿÿð ÿÿÿÿø ÿÿÿÿ ÿÿÿÿÿÿÿÿ ) ÿà ÿþ ÿà ÿÿÿð ÿÿø ÿÿþ ÿÿà ÿÿÿÀÿÿ€ 2 þà ?çÿ •ð •ÿÿà ÿÿü ÿÿø ÿÿ ÿÿÿ ÿÿà . üà Ãÿ€ ?ø ÿÿ€ÿÿü ÿÿð ÿþ ÿÿþ ÿÿð : ùð ÿÿ€ ü ÿÿ€ ÿÿþ ÿÿà ÿø ÿÿü ?ÿø : ñð ÿ ÿÀ ü ÿÿ •ÿÿ ÿÿà ÿð ÿÿø ÿü " áð þ ÿà þ ÿÿ ?ÿÿ ÿÿà ÿà ÿÿø ÿü ?Áð ü •ð ÿ ÿÿ ?ÿÿ€ÿÿà ÿÀ ÿÿø ÿþ ••ð ø •ð ÿ ÿÿ ÿÿ€ ÿÿà ÿÀ ÿÿø ÿÿ • ð ð ?ø ÿ€ ÿÿ ÿÿÀ ÿÿà ÿ€ ÿÿø ÿÿ€! ÿ ø ð ?ü ÿÀ ÿÿ ÿÿÀ ÿÿà ÿ ÿÿø ÿÿ€þ ø à ü ÿÀ ÿÿ ÿÿÀ ÿÿà þ ÿÿø ÿÿÀ ü ø À þ ÿà ÿÿ ÿÿà ÿÿà ü ÿÿø ÿÿà$ ü ø ?À þ ÿà ÿÿ ÿÿà ÿÿà ?ø ÿÿø ÿÿà ø ø ?€ ÿ ÿð ÿÿ ÿÿà ÿÿà •ð ÿÿø •ÿð- ð ø ? ÿ ÿð ÿÿ ÿÿà ÿÿà ÿð ÿÿø •ÿð- ð ü • ÿ€ •ø ÿÿ ÿÿð ÿÿà ÿà ÿÿø •ÿø4 à ü ~ - ÿ€ •ø ÿÿ ÿÿð ÿÿà ÿ ÿÿø ?ÿø4 à ü þ - ÿ€ •ü ÿÿ ÿÿð ÿÿà ÿ€ ÿÿø ?ÿø4 à ü ü ÿÀ ?ü ÿÿ ÿÿð ÿÿà ÿ ÿÿø ?ÿü À ü ü ÿÀ ?ü ÿÿ ÿÿð ÿÿà þ ÿÿø ?ÿü<À 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/ColorSpace 6 0 R /Width 378 /BitsPerComponent 4 /Height 86 /Subtype/Image /Type/XObject /Length 16254 >> stream #CCCCCE` cCCCCCEg „3434343436` „3434343436` CCCCCCCCCCCCC` CCCCCCCCCCCCC` h393 939393939393 h393939393939393 CCCCCCCCCCCCCCCCChCCCCCCCCCCCCCCCCC` 34343434&&(434343434343 434&&(43434343` 34343434343434343434343434†! #43434 34343434343434 43434343434343436 4343434343434343434343438&` ƒCCCCC‚ CCCCCCCCCC‚` ƒCCCCCH CCCCCCCCCCCCCCCC CCCCCCCCCCCCH` cCCCCCCCCCCCCCCCCCCC` CCCCCCCCCCCCCCCCB CCCCCC CCCCCCCCCCCCCCCCCCCCC% i39398 )3939393 )393937 939393939393939393939393939393§ )39393 93939393939393 39393939393939396 39393939393939393939393939398 CCCCH cCCCCC` CCCCC CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC' cCCCCCCCCCCCCCCCCCCC` CCCCCCC CCCCCCCCCB CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC` ƒ4348` ƒ434347 $34346 434343434343434343434343434 34343€ $3434343434343434343 34343434343434346 3434343434343434343434343434343 CCCC@ CCCCCCC #CCCC€ CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH cCCCCCCCCCCCCCCCCCCC` CCCCCCCCC CCCCCCCE CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH ƒ9393 ƒ93939396 39398 &&#9393939393939393&&©3939393 93937 f&#939393939393939†&` &&(3939393939398' &&93939393939393939 &&&©3939393936 CCCEC@ CCCE#CCCC #C CCC cCCCCCCCCCCCCE cCCCCCCCCCCC #CCCCCCCCCCCH #CCCCCCCCH` CCCCCCCCCCCCC" CCCCCCCCC „343`30 „343`43431 43436 „34343434348` „34343434347 43434343434` 343434 38 d343434343431 343434343` CCCG C@ CCCG ƒCCCC ƒCCCC CCCCCCCCCC@ CCCCCCC CCCC cCCCCCCCCCB CCCCCCC CCCCCCCCCCC CCCCCCCCG )393` 96 i393` 93930 93 937 9393939393` i3939393939€ 9393939390 939393 93939393936 ƒ93939393` CCC G CB CCCG CCCCH CCCCH CCCCCCCCCC CCCCCCCCCCB CCCCCCCCC@ CCCCCH cCC CCCCCCC@ CCCCCCCCG 434` 46 434` $3434 d3434€ „343434346 ƒ4343434343 434 343434 43434€ $343434343€ „34343434 #CCG CC cCCG CCCCG CCCCG cCCCC CCCCE CCCCCCCCCC` CCCCCCCCC` CCCCC cCCCCCCCCC` CCCCCCCC 939€ 39 939€ 93938 93939 #93939393 6 39393939390 393939393 )39397 #939393939 939393936 CCH CC CCH #CCCC` cCCCC cCCCCCCCCE CCCCCCCCCCB CCCCCCCCC` CCCCC cCCCCCCCCC` cCCCCCCCC #431 d34 #431 d34347 34347 #434343436 ƒ4343434348 343434343 43431 #434343434 343434340 CCC` cCC` CCC` CCCCH CCCCH cCCCCCCCCB CCCCCCCCCC CCCCCCCCC` #CCCC€ cCCCCCCCCC` CCCCCCCCE 938 #93 938 93939` 93939` )393939396 3939393939 939393939 93938 )393939393 939393939` CCG cCC CCG c CCCCC CCCCC@ cCCCCCCCCB CCCCCCCCCC CCCCCCCCC` CCCC cCCCCCCCCC` cCCCCCCCC ƒ43€ 3430 ƒ43 „ $34347 $34346 $343434346 34343434340 434343434 34348 $343434343 343434347 CCC CCC@ CCC C` CCCCH CCCCC cCCCCCCCCE CCCCCCCCCC@ CCCCCCCCC` CCCCG cCCCCCCCCC` CCCCCCCCH 9 36 9397 936 3 93939` 93939` #939393936 93939393936 393939393 39393` #939393939 939393939` CC@ CCCB CC@ C@ CCCCC CCCCC cCCCCCCCCE cCCCCCCCCCE CCCCCCCCC` CCCC G cCCCCCCCCC` CCCCCCCCC #43 4346 #43 30 434340 434347 #434343436 $34343 43436 343434343 „3434 #434343434 CCCCCE CCCCH „343434340 CCC CCCE #CC CG CCCCCE cCCCCCCCCB cCCCCCCCCCB CCCCCCCCC` cCCCCCCCCC` cCCCCCCCCE 93 8 3939 938 96 393938 393939 )3939393 c9393939396 939393939 ©3939€ )393939393 c939393939 CCG CCCC CCG CB CCCCCC #CCCCC cCCCCCCCCB CCCCCCCCCH CCCCCCCCC` CCCCH cCCCCCCCCC` CCCCCCCCC 43 0 3434 430 48 ƒ43434 #43434 $343434346 4343434343 434343434 #43431 $343434343 434343434 CC` CCCC CC` CC cCCCCC@ cCCCCC@ cC CCCCCCCE CCCCCCCCCC CCCCCCCCC` CCCCC cCCCCCCCCC` CCCCCCCCC@ )39` #9393 )39` )39 )393930 )393937 #939393936 3939393939 393939393 c93937 #939393939 3939393937 CCC cCCCC` #CC cCC cCCCCCE CCCCCE cCCCCCCCCE CCCCCCCCCE CCCCCCCCC` CCCCC` cCCCCCCCCC` CCCCCCCCCE 436 #4343 436 „34 d343436 343438 #434343436 3434343436 343434343 d34348 #434343434 3434343438 CCB CCCCC@ CCB CCC` CCCCCC CCCCCC cCCCCCCCCB cCCCCCCCCCB CCCCCCCCC` ƒCCCC cCCCCCCCCC` CCCCCCCCCC 390 939 390 390 393 939393 939393` )393939396 #9393939396 939393939 39398 )393939393 9393939393` CC@ CCCCC@ CC@ CCC@ CCCCCC` CCCCCC` cCCCCCCCCB cCCCCCCCCCB CCCCCCCCC` #CCCCC cCCCCCCCCC` cCCCCCCCCC` 34 434340 34€ 3430 434343 434343 $343434346 34343434347 434343434 434343€ $343434343 $343434343 CC` CCCCCE CC` CCC@ CCCCCC€ CCCCCC@ cCC CCCCCCE CCCCCCCCCC@ CCCCCCCCC` #CCCCCCG cCCCCCCCCC` cCCCCCCCCC@#93` 393936 c93 9396 3939390 &&' 3939390 #939393936 93939393930 393939393 93939398 #939393939 #9393939390cCCC" CCCCCE cCCC" CCCB CCCCCC@ C CCC CCCCCC@ cCCCCCCCCE CCCCCCCCCC` CCCCCCCCC` CCC CCCCC cCCCCCCCCC` cCCCCCCCCC@#43431 343436 #43431 4346 3434340 d34346 3434346 #434343436 4343434343 343434343 343434343€ #434343434 c4343434346CCCCCC CCCCCH cCCCCC` CCCH CCCCCCE ƒC CCCC CCCCCCE cCCCCCCCCB cCCCCCCCCCC CCCCCCCCC` CCCCCCCCCG cCCCCCCCCC` CCCCCCCCCE9393 96 937 939393 9393937 )3939 9393936 393939 9393936 )393939396 93939393938 939393939 39393939398 )393939393 3939393936CCCCCCH CCCCCC CCCCCCH cCCCC CCCCCCE CCCCCC` CCC CCCE cCCCCCCCCB CCCCCCCCCCG CCCCCCCCC` CCCCCCCCCCC cCCCCCCCCC` CCCCCCCCCE4343434 4343 43 4343434` $3434` 4343436 3434340 4343436 $343434346 c43434343430 434343434 „343434343430 $343434343 3434343438CCCCCCC` CCCCCC CCCCCCC` ƒCCCC` CCCCCCB CC CCCC@ CCCCCCC cCCCCCCCCE CCCCCCCCCCC` CCCCCCCCChCC CCCCCCCCCCB cCCCCCCCCC` CCCCCCCCCC3939 393 )393939 3939393 39393 )3939396 9393930 3939393 #939393936 93939393939 3939393939393 9393939393 #939393939 9393939393CCCCCCC@ cCCCCCC CCCCCCC@ CCCCC` cCCCCCCH CC CCCC@ CCCCCCC cCCCCCCCCE #CCCCCCCCCCG CCCCCCCCCCCC CCCCCCCCCCC` cCCCCCCCCC` CCCCCCCCCC3434 3430 $343434 34343430 343430 $3434343 4343430 $3434343 #434343 436 h34343434343€ 343434343434343434343430 #434343434 4343434343CCCCCCC@ cCCCCCC CCCCCCC@ CCCCC@ cCCCCCCC CC CCCC@ cCCCCCCC cCCCCCCCCB CCCCCCCCCCCH CCCCCCCCCCCC CCCCCCCCCCCB cCCCCCCCCC` CCCCCCCCCC9393 9390 #939393 93939390 939390 #9393939 3939390 #9393939 )393939 396 ©393939393937 9393939393938ƒ9393939393 )393939393 3939393939CCCCCCC@ cCCCCCC CCCCCCC@ CCCCC@ cCCCCCCC CCCCCC@ CCC CCCC cCCCCCCCCB CCCCCCCCCCCCC CCCCCCCCCCCC CCCCCCCCCC cCCCCCCCCC` CCCCCCCCCC43434340 #434343 43434340 434346 c4343438 3434340 4343434 $343434348&&(3434343 4343434‡ 434343434348 43434343431 $343434343 3434343434CCCCCCC@ cCCCCCC CCCCCCC@ CCCCCE CCCCCCB CC CCCC@ CCCCCCC cCCCCCCCCCCCCCCCCCCCCCCCCCH CCCCCCCCCCC CCCCCCCCCCH cCCCCCCCCC` CCCCCCCCCC3939 393 i393939 39393930 393936 3939396 9393930 3939393 #939393939393939393939393 9` 39393939398 #9393939393` #939393939 9393939393CCCCCCC` CCCCCC CCCCCCC@ CCCCCE CCCCCCB CC CCCC CCCCCCB cCCCCCCCCCCCCCCCCCCCCCCCC` CCCCCCCCCC CCCCCCCCCC cCCCCCCCCC` CCCCCCCCCB3434343 343434 3434343 343434 3434346 434343 3434346 #43434343434343434343434 3434343438 43434343431 #434343434 4343434346CCCCCCC` CCCCCB #CCCCCC` cCCCCCC CCCCCE CC CCCC` CCCCCE cCCCCCCCCCCCCCCCCCCCCC% CCCCCCCCC€ CCCCCCCCCCH cCCCCCCCCC` CCCCCCCCCE©393 939 939397 )393939 #939393 393936 393939 393936 )3939393939393939396&` 939393939 #9393939393` )393939393 3939393936cCCCCCC` #CCCC` cCCCCCC` cCCCCCC CCCC@ CCCCCC` C CCCG cCCCCCCCCB CCCCCCCCC` CCCCCC CCCC 3436 #434343 cCCCCCCCCC` CCCCCCCCCE$343434 $343434 f(430 343434` f(430 $343434346 434343434 43434343436 $343434343 $3434343430cCCCCCC` bg CCCCCC` cCCCCCC CC@ #C CCCC CC@ cCCCCCCCCE CCCCCCCCC` ƒCCCCCCCCCC cCCCCCCCCC` cCCCCCCCCC@ 939 393 939393 )393939 39 )39393 390 #939393936 393939393 c9393939393 #939393939 #9393939390 CCCCCC` CCCCCC` cCCCCCC CC` cC CCCC CC` cCCCCCCCCE CCCCCCCCC` CCCCCCCCCC@ cCCCCCCCCC` cCCCCCCCCC` 434 343 434343 $343434 $34` $34346 d34 #434343436 343434343 43434343436 #434343434 ƒ434343434 CCCCCC` CCCCCC@ cCCCCCC cCC CCCCE cCC cCC CCCCCCB CCCCCCCCC` ƒCCCCCCCCCC cCCCCCCCCC` CCCCCCCCCC 393939 3939390 #939393 393 93936 ƒ93 )393939396 939393939 c9393939393 )393939393 9393939393 CCCCCC@ CCCCCC@ cCCCCCC CCB C CCCG CCH cCCCCCCCCB CCCCCCCCC` CCCCCCCCCC@ cCCCCCCCCC` CCCCCCCCCH ƒ43 4340 #434340 #434343 346 43430 346 $343434 346 434343434 43434343438 $343434343 4343434346 cCCCCC@ cCCCCC@ CCCCCH CC@ C CCC@ CC@ cCCCCCCCCE CCCCCCCCC` cCCCCCCCCCC cCCCCCCCCC` CCCCCCCCC@ i39 3930 393937 393936 93 39390 930 #939393936 393939393 9393939393 #939393939 3939393930 CCCCCE CCCCCE CCCCC@ cCC` C CCC` cCC` cCCCCCCCCE CCCCCCCCC` CCCCCCCCCCG cCCCCCCCCC` CCCCCCCCC` 34 3436 343436 ƒ4343` ƒ43 3434 ƒ43` #434343436 343434343 43434343438 #434343434 343434343` CCCCCB CCCCCH CCCG CCH C CCC` CCH cCCCCCCCCB CCCCCCCCC` cCCCCCCCCCC cCCCCCCCCC` cCCCCCCCCH ©3 9393 ©39393 &' 937 9393` 936 )393939 396 939393939 9393939393 )393939393 #939393936 cCCCCC CCCCC CC@ C CCC CC@ cCCCCCCCCB CCCCCCCCC` CCCCCCCCCCG cCCCCCCCCC` CCCCCCCCC@ 3 4343 34343 #43 $343 #43 $343434346 434343434 „3434343438 $343434343 343434343 CCCCC` CCCCC€ CCC cCCH CCC c CCCCCCCCE CCCCCCCCC` CCCCCCCCCC` cCCCCCCCCC` CCCCCCCCC 939390 939390 936 #936 938 #939393936 393939393 93939393930 #939393939 939393938 cCCCCG cCCCCB CCG CCE CCG cCCCCCCCCE CCCCCCCCC` CCCCCCCCCCE cCCCCCCCCC` CCCCCCCC@ 34346 34348 ƒ43€ 436 ƒ43€ #434343 436 343434343 „3434343434 #434343434 ƒ43434343 endstream endobj 8 0 obj << /Length 4128 /ImageMask true /Decode[1 0] /Width 378 /Height 86 /Type/XObject /Subtype/Image /BitsPerComponent 1 >> stream ÿÀ ü ü àà ÿÿ ÿÿà ?ÿÿ€ ÿÿø ÿÿÀ< ÿà þ ü àÀ ÿÿ ÿÿà ÿÿ€ ÿÿø ÿÿÀ% ÿà þ ø à?€ ÿÿ ÿÿà ÿÿÀ ÿÿø ÿÿ€/ •ð ÿ ø à€ ÿÿ ÿÿà ÿÿÀ ÿÿø ÿÿ •ð ÿ ð àÿ ÿÿ ÿÿà ÿÿà ÿÿø ÿÿ ?ø ÿ€à àÿ ÿÿ ÿÿà ÿÿ ð ÿÿø ÿþ ü ÿÀà Áþ ÿÿ ÿÿà ÿÿð ÿÿø ÿü 2 ü ÿÀ?À Ãü ÿÿ ÿÿà ÿ ÿø ÿÿü ÿø 2 þ ÿà€ Çø ÿÿ€ ÿÿð ÿÿø ÿÿü •ÿð > ÿ •ðÿ Ïø ?ÿÿÀ ÿÿø ÿÿü ÿÿþ ÿÿà 8 ÿ€ ?ûÿ ßð •ÿÿà ÿÿü ÿÿÿ ÿÿÿ ÿÿÀ 8 ÿÀ ÿþ ÿà ÿÿÿü ?ÿÿÿ •ÿÿÿÀ?ÿÿÿàÿÿ€ ) ÿà ÿü ÿÀ ÿÿÿÿÿø ÿÿÿÿð ÿÿÿÿÿÿÿÿÿÿÿÿÿ 2 •ø ÿø ÿ€ ÿÿÿÿ ÿø ÿÿÿÿð ÿÿÿÿÿÿÿÿÿÿÿÿü . ?ü ÿð ÿ ÿÿÿÿÿø ÿÿÿÿð ÿÿÿÿÿÿÿÿÿÿÿÿø : ÿ ÿð ?ü ÿÿÿÿÿø ÿÿÿÿð ÿÿÿÿÿÿÿÿÿÿÿÿà : ÿà ÿþ ÿø ÿÿÿÿÿø ÿÿÿÿð ÿÿÿÿÿÿÿÿÿÿÿÿ " ÿþ ÿÿÿàÿð ÿÿÿÿÿø ÿÿÿÿð ÿÿÿÿÿÿÿÿÿÿÿø ÿÿÿÿÿÿÿÿÿÀ ÿÿÿÿÿø ÿÿÿÿðÿÿÿÿÿÿÿÿÿÿÿ€ ÿÿÿÿÿÿÿÿ€ ÿÿÿáÿÿÿþ ! ÿÿÿ€•ÿÿø ÿÿü ÿÿÀ ÿÀ ÿü $ 4 4 4 < 9 > ÿ ÿð •ð - À ð- ü ?€ ÿþ < ÿ€ü-: ? ÿþ < € x ÿ ø-: ÿð ÿü - À ø- ÿð ÿþ - À ü- ÿ€ € ÿþ < - ÿÀ ü-( À •À À < ? à þ-/ ð à - À ÿ-Àßž - À óà À < -ÀÏž - À ñð À < - À ÇÞ - À áð À < - À Çþ - À ÿø À < À Ãþ - À ÿø À < > À ÿü À < ? à áþ ÿÀ àþ ÿ €> À < ÿ€à~ > À < ÿ à> ü ÿ ð ø~ - À ü- -ð à? - À - À ûà À < >àÿž <àïž < à ïÞ < à çþ > à ãþ à áþ ð ð ÿþ ÿÀ ð ÿü ÿ€Àþ ð ?ð ÿ € ø þ- - À ÿÀ À < > à ÿ-/ ÿà à- ÿà Àÿà àð àð ð? ø~ ‡ÀÁþ -Àþ ÿ€€| À < À~ ü - < ø ÿ€ ü 8 ø ÿ€ ü 8 - À -< - ƒ€ - øƒ‡Àø ðî- ð •À <> ÁÇÇ >•ð| ü‡áü?‡øþð •À <ÿ ÃÏç ••ðþ < ü• •óþÇøþÿŸø À<yÿßç ÿÿñþ endstream endobj 9 0 obj << /ColorSpace 6 0 R /Width 378 /BitsPerComponent 4 /Height 86 /Subtype/Image /Type/XObject /Length 16254 >> stream CCCCC CCCCC CCC CC@ CCC cCC CCCCCCB CCCCCCCCC` CCCCCCCCCC` cCCCCCCCCC` CCCCCCCCC 43434 „3434 436 340 438 $343434346 434343434 43434343430 $343434343 434343431 cCCCC@ CCCC@ #CC@ CC@ #CC@ cCCCCCCCCE CCCCCCCCC` CCCCCCCCCCB cCCCCCCCCC` CCCCCCCC€ 93936 93936 939` 93 939 #939393936 393939393 #9393939393 #939393939 ©39393939 CCCCC CCCCC CCH CC` CCH cCCCCCCCCE CCCCCCCCC` CCCCCCCCCC cCCCCCCCCC` CCCCCCCCG $3434 d3434€ 3430 43 3431 #434343436 3434343430 43434343431 #434343434 c43434343 CCCCG CCCCG CCC CC CCC #CCCCCCCCB CCCCCCCCC@ CCCCCCCCCC H cCCCCCCCCC #CCCCCCCH 93938 ©3939 ƒ936 39 ƒ938 9393939393 9393939390 39393939393` 93939393937 93939393 CCCC CCCC CCC cC CCC CCCCCCCCCC CCCCCCCCCB CCCCCCCCCCC@ CCCCCCCCCCH #CCCCCCCH 34346 34348 „348 #6 „343` c43434343431 ƒ4343434343` 343434343438 c434343 43434€ $34343434€ #CCCC CCCC€CCCG cB CCCG CCCCCCCCCCCC CCCCCCCC CCC‡ ƒCCCCCCCCCCCC' CCCCCCCCCCCCH CCCCCCCCH 39396 393989393` 89393` &39393939393939& (393939393 9393' )39393939393939† f393939393939396 #939393939 #CCCC #CCCCCCCG CCCCG CCCCCCCCCCCCCCCCCCCCCC` cCCCCCCCCCCCCCCCCCCE CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC CCCCCCCCCCCCCCCCCCCG 43438` 4343434` $3434` 3434343434343434343434 #4343434343434343436 434343434343434343434343434343434 3434343434343434346 cCCCCE CCCCC‡ CCCCG CCCCCCCCCCCCCCCCCCCCCC` cCCCCCCCCCCCCCC CCCCB CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH 939396 h939396 h93938 9393939393 939393939393 )3939393939393939396 393939393939393939393939393939393 93939393939393938` CCCCCE cCCCCCCCH` hCCCCC CCCCCCCCCCCCCCCCCCCCCC` cCCCCCCCCCCCCCCCCCCB CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCB ƒ434343†` (34343434343† &3434347 4343434343434343434343 $3434343434343434346 343434343434343434343434343434343 43434343434348 ƒCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH CCCCCCCCCCCCCCCCCCCCCC` cCCCCCCCCCCCCCCCCCCE CCCCC CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHbe` 939 39393939393938g93939393939393938` CCCCCCCCCCCCCCH CCCCCCCCCCCCCC H „343434343436` „343434343436` hCCCCCCCCCg hCCCCCCCCCg &#939†& &#939†& &` &` CCCCCE C@ cC #CCC% cCH C` CCCC" CC C@ 343436 „34` 343436 CH c434347 #4343430 30 43 $3 cCCCE cCCCCCC@ $34 ƒ43434€ CC 3 347 CCCCC 30 B CCHb#CC cCCCCCC@ C@ CC #9 #939 9 ©37 3937 939€ 90 CC C@ C` C` CH cC@ C#CG C@ 43 34 „3`34` CE C@ )3 )3 ƒ90 37 c98 30 beb` cC CC 36 cCCG CCEbCCH C` CCH 93 CCCCCC C@ 98` CCC ƒ9€ 36 39 CG CeCH C@ 46 cC 40 34 36 cC CC CC 3 96 c98 C` C@ 3 93 39 cCCC CC CE #4 #4 34` cC #4c46 40 4 4 4(43` 40 CCCCC@ CH cC C` #C C`ƒC€C@ 393930 )3 37 30 3 )3 93 36 C@ CC CB 30 $3 43 cC CC $3 43$3 43` 30 cC CH C` C` CC C@ C` CC C@ 34 $3 3 43 „343434 3 „3830 CG CG CE #9 ©37 9390 CG CC cC€ cC€ CC 939 36&&&)36 30 cC cCCC` C` CCC@ 93 C` CC CCCCCCC@ CE 93` C 39€ 93` 3 9 36 39 c98 39 9 CC CCCbCCC CE CC d34343€ 36 340 #4 CCHbCCE CC d34 34 cCCC% @ cC CC CE 46 9 90 9 cC CC CB cC CB CC cC CCHhCCH 434347 „34343€ cCCC' cCCC' CCC` „3` 4 cC C` 43 34 CC` C` #C@ CCCCCC CC@ C d343431 CCCHb CH CC cC B cG 93930 93937 c@ 4 c4 C C` CCCH c@ 9393 i6 3 9 b #6 4` CCCCG CCCC ƒ0 C"eb` C"eCE HbhC@ C` 30 ` b` 4 $0 4 c@ C@ C H C C C 3 &&` 'f' 90 90 && f& && &' f & & 3'&' f &g&' 3 i6 &&` 3 ' ' &' & ' f& (3&g& &' H #CCG HCE C C` #CC CCH #CC CCC` cHC CCC CCCC c@ CCCC H cB CCG H H cB #CC` C E CCC CCCbC #CC` d6 46 48 431 4 c4 3†31 „8$3 4†46 4(40 ƒ43 c4#4 34#4 #048„3 d6 4036ƒ4 6 3 „038304 ƒ0#8#4#434(4 3ˆ30 endstream endobj 10 0 obj << /Length 2352 /ImageMask true /Decode[1 0] /Width 378 /Height 49 /Type/XObject /Subtype/Image /BitsPerComponent 1 >> stream ?÷ ø ÿ<óžóÏ8ð÷žx yà?ùç=Ǽç-çœsÎ< ?ÿ ð þ8wžáÎ8áãœx qÀ?óÇ9Ç8çç¼sŽ% 8 ?î à þ8÷ÀãÀùáÃœp-qÀ?ã‡9Ï8çð8óŽ/ à -ãðÿÇùÁÀpñÀ8‡9Îx 8ü8ç€ 8 à ãùÿùÁÀ8páÀx‡9Îp ¸þ8ç x-=à àùÿžqÁÀ8páÀx‡9üpø?8ç x 9À p yÀ qÃÇ8p ãÀx •püqÃðxç 2 p 9À -qî9ÇœóÃÏ8ðã€p ŽpøqÃó•qç 2 p-yÀ -qÎ9Ç<óƒÎ8à9ã€p žpøsÃãÎqÇ<> pñÀ -Ïùÿ?óƒþxà9ÀpþpðÃãþÇø8 ãüpà9ÀðüpðƒÃüÇø8 ã€øpà9Àðøpð?Áø=Ãð) ð ñÀ--••ñþðÀ--? àüà à À : € À € € 2 . : " ! $ - p •ÁÀ -ð •ãÀ - <ð ÿãÀ - -x ðà 4 -ð àà 4 àáüƒñÁÀàãÁøƒð~ 4 Àçüÿ‡ùÃÀàãŸãü?‡øÿ ÁçüÿÏùÕàç¿çü•Ïùÿ < ?•Ï<óÏ9Ç•àç<ç sÎ9Ç 9 ?•Î<ãÎ9Ç Áç8ï óÎ;Ç > ?•Î 8ãž9ÏÁç>•ƒ‡ ?Þ9ãŸùÎÁÇ?üÃÿ ;ÃÜ9ßùÞÁÏ•üÿ‡ãÿ : {Ãœ9ßùÜÃÎÏýóƒ÷þ : yãœyÇœ üƒÎÎç€÷€ ( qãœyÇpø‡ŽñÎ9 Ç<w / póŸó‡ðð ÿ qóœñÇðøŸŽóÎyÏ<÷ž / ÿ•ùÿ?çü Ãü pÿó‡àð þ ••ñÿðó‡€à ð > À÷ •ð à À À € endstream € endobj 11 0 obj << /ColorSpace 6 0 R /Width 378 /BitsPerComponent 4 /Height 49 /Subtype/Image /Type/XObject /Length 9261 >> stream cCCCB H C C` CCCCG H cB C C` H E cG #@ CH CG C` C C` C C` C cHb#C` C C E C C` H #@ C C`C C` E B cH #@ #4347$7 4 $6 3434` ƒ0 6 3 &`$0 6 „0 ƒ0 4€ 4 3 4 3 4 3 4 #4348 c6 3 #0 4 3 ƒ0 $0 3 4 4 &`c6 6 ƒ0 $0 #CCC@ƒ@ C c@ Cb#C@ C` cE CB C B C` C C e B C C` E C CCCH` c@ C c@ C E C` ` C B CE c@ cG C` b` 90 3 8 3 9 30 9†&ƒ0 93§ 3¦&©7 939 3 3 6 9 3 c7 3 9€ ©0 9 ©€3 ƒ0 9 9 )0 ƒ97 )0 #0 9 C` C` B C` E C@ CCCC@ CC CCCC@ CCCC C B c@ H C c@ B C ` C` H C` C C` C C`C CC C c@ C 4 3 d6 3 #6 30 4&&& ƒ403&&& 3€4 6 6 $0 6 8 #0 6 4 4 6 4 3f3 4 4&4` $31 4 3 4 C C c@ C cG C€C C@ C H C E cE g ƒ@ B E C` cG C C` cB C CcE C e CcH #B C` C` C e 3 9 30 9 ©0 9 8 9 ©0 #0 9 3 6 i6 c7 #6 i6 3 )7 6 9 #0 3 3 ©0 3 930 3 9 397 #0 )6 3 9` 8 9 C C C` H C@ C` C C C@ #@ C C cE #B c@ cE #@ C` c@ c@ C` c@ C C` C C CC` C H CC cG #@ C C C E 6 46„3 6 4 4 3†36 „8(3 4†48 #4(46 #0 c4(4€3` „0 #0 4 3 6 36#4` 6 43 3†31 #4` #8(4€3†f4 3†30 cE CCCG B C` C` CCC€ CCH CCC CCC@ C€ CCH C C` #@ C C` cE #CCG E cE CCC cH CCH CC H CCC f' f9† f & &` &` & &` && ' h3' &` f' &` f3& ƒ6` )6 f9† ƒ¦f &` (8 ' ƒ7 f3' ©7 #8 C C 3` H 4` H #7 b` )7 e` #@ CCCH #B H c@ H 40 4€d6 $0 3434 c6 C` #H g C cHbhC@ g 3 9€ #7 3 30 C`#H C` #@ c@ 3 3€ &` &&3 &&` f&! !&&` &&` f&& ' ' 30 #0 &` f&' && C C CCC cCCC@ CCC` E cG C` c@ C` CCC` CCE ƒCC@ CCC #CCG C` C 937 9` 3¦38 )3¦36 i3&30 8 3 9 90 3`c9(90 36#9 3¦ƒ6 i8(3 9†©6 CC c@ C C C cG C@ C d6 C C C cH cE cB cE #G C H E #@ C` H #43` 4 „0 #6 40 c1 4 4 $6 #1 4€ &`#6 3 C #0 4 3 4 4 3 30 & cBC€ H C` c@ C` c@ C 8 3 c@ C 6 )38 E ƒ6&)8 C #B B C C C` H #H 9790 96&#6 9390 #96 #@ C C cG C b#@ CH 6 3 CCCC` C C` )0 3 B c@ E )0 3&&90 3 ƒ0 C E CC CCCCB #CCC CC CCCCE 8&&&` 3 3 ƒE c@ $6 cE c@ 3 30 9 d6 #0 3 #6 ƒE C` 90 3 9 6 3 9 h46 3†&&'3• 4 C C` 3` 6 4 $3 $0 3 4 C` C` c@ C C` H C` E 3 C cE #G C 6 3 930 30 43 34348 E CCCC` C CCCE c@ E CCC ƒE &&& & && && CG C` C C E C E cB && ' ƒCCG &g& CCCE CCH #CCG f&f' f ' && && C` 3 E ƒ0 b endstream endobj 12 0 obj C 6 9 4 CCC f' 30 && 30 ©€i6 C` 3 „8 3 4†43 #0 8 4(47 d3(30 46„3`4ˆ43 #4(4€36ƒ4 C C 4 #B C C C` C cC` C`cB cE C` C` C 3 d36 4†&& C << /Domain[0 1] /Size[255] /FunctionType 0 /Length 1020 /BitsPerSample 8 /Range[0 1 0 1 0 1 0 1] >> stream - - ! 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P " Q " R # S # T # U $ V $ W % X % Y % Z & [ & [ ' \ ' ] ' ^ ( _ ( ` ) a ) b ) c * d * e + f + g + h , i , j - k - l m . n . o / o / p / q 0 r 0 s 1 t 1 u 1 v 2 w 2 x 3 y 3 z 3 { 4 | 4 } 5 ~ 5 5€66‚7ƒ7ƒ7„8…8†9‡9ˆ9‰: Š-: ‹-; Œ-; •-; Ž< •< •= ‘= ’= “ > ” > • ? – ? — ? —!@ ˜!@ ™!A š!A ›!A œ"B •"B ž"C Ÿ"C "C ¡#D ¢#D £#E ¤#E ¥#E ¦$F §$F ¨$G ©$G ª$G «%H «%H ¬%I -%I ®%I ¯&J °&J ±&K ²&K ³&K ´'L µ'L ¶'M ·'M ¸(N ¹(N º(N »(O ¼(O ½)P ¾)P ¿)P À)Q À)Q Á*R Â*R Ã*R Ä*S Å*S Æ+T Ç+T È+T É+U Ê+U Ë,V Ì,V Í,V Î,W Ï,W Ð-X Ñ-X Ò-X Ó-Y Ô-Y Ô.Z Õ.Z Ö.Z ×.[ Ø.[ Ù/\ Ú/\ Û/\ Ü/] Ý/] Þ0^ ß0^ à0^ á0_ â1_ ã1` ä1` å1` æ1a ç2a è2b è2b é2b ê2c ë3c ì3d í3d î3d ï3e ð4e ñ4f ò4f endstream endobj 13 0 obj [/Separation/PMS#20323/DeviceCMYK 2 0 R] endobj 14 0 obj << /Length 2608 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q /CS0 cs 0.5 scn -0.5 -1.75 613.8309 795.5 re f 1 scn 0 85.4999 613.998 706.5 re f /GS0 gs 5 w 0 0 0 0 K 0 86 m 612 86 l S 0 0 0 0 k 306.5 132.83 m 365.783 132.83 l 375.7241 132.83 383.783 124.7711 383.783 114.83 383.783 56 l 383.783 46.0588 375.7241 38 365.783 38 c 247.217 38 l 237.2759 38 229.217 46.0588 229.217 56 c 229.217 114.83 l 229.217 124.7711 237.2759 132.83 247.217 132.83 f* 306.5 132.83 m 365.783 132.83 l 375.7241 132.83 383.783 124.7711 383.783 114.83 383.783 56 l 383.783 46.0588 375.7241 38 365.783 38 c 247.217 38 l 237.2759 38 229.217 46.0588 229.217 56 c 229.217 114.83 l 229.217 124.7711 237.2759 132.83 247.217 132.83 W* n q 146.51282 0 0 33.1788 232.073 94.6542 cm 1 g /Im1 Do Q c c c c q 146.51282 0 0 33.1788 232.073 94.6542 /Im2 Do Q q 146.51282 0 0 33.1788 232.073 61.4754 1 g /Im3 Do Q q 146.51282 0 0 33.1788 232.073 61.4754 /Im4 Do Q q 146.51282 0 0 18.9042 232.073 42.5712 1 g /Im5 Do Q q 146.51282 0 0 18.9042 232.073 42.5712 /Im6 Do Q Q /GS2 gs BT /F0 1 Tf 14 0 0 14 124.6467 15.4044 Tm 0 Tr /CS0 cs 1 scn 0.2777 Tc (www)Tj 3.11242 0 TD 0.2778 Tc (.pkdcur)Tj 5.44593 0 TD 0.0278 Tw (e.org \245 1-800-PKD-CURE)Tj ET /GS0 gs q -0.626 283.522 612.626 372.597 re W n q 160.803 385.987 292.079 248.317 re W n BT /F1 1 Tf 50 0 0 50 222.2796 397.087 Tm 0 0 0 0 k 0 Tc (on)Tj 1.52699 0 Td [(PK)(D)]TJ /GS2 gs cm cm cm cm cm /F2 1 Tf 225.173 0 0 225.173 238.8416 447.187 Tm /CS2 cs 0.6 scn (&)Tj /GS0 gs /F3 1 Tf 122.94 0 0 122.94 160.803 488.489 Tm 0 0 0 0 k (Q)Tj 1.6538 -0.10119 TD (A)Tj ET Q Q BT /F4 1 Tf 10 0 0 10 258.3874 325.606 Tm 0 0 0 0 k -0.0002 Tc 0.0273 Tw (Originally Created by)Tj 0.38282 -1.1 TD 0 Tc 0.027 Tw [(P)18(atricia Gabow)112(, MD)]TJ -0.73167 -1.1 TD -0.0001 Tc 0.0273 Tw (Jared J. Grantham, MD)Tj -2.89146 -1.1 TD (University of Kansas Medical Center)Tj 0.53516 -2.2 TD -0.0002 Tc (Reviewed and Updated (2002) by)Tj 2.63313 -1.1 TD 0 Tc (Arlene Chapman, MD)Tj 1.46924 -1.1 TD 0.027 Tw [(Robin P)32(ost, RN)]TJ 0.08679 -1.1 TD 0.0273 Tw (Joan Allen, RD)Tj -0.56045 -1.1 TD -0.0003 Tc (Emory University)Tj -3.62871 -2.2 TD -0.0002 Tc (Reviewed and Updated (2006) by)Tj 3.57112 -1.1 TD (Dr)Tj 1.07617 0.00001 TD (. T)Tj 1.05904 0.00001 TD -0.0001 Tc (ed Steinman)Tj -3.57808 -1.10002 TD (Harvard Medical School )Tj -3.10518 -1.1 TD 0 Tc (Beth Israel Deaconess Medical Center)Tj /F5 1 Tf 1 0 0 1 -1000 1792 Tm 1 g -0.179 Tc 0 Tw ( )Tj /F6 1 Tf 0.09399 0 Td -0.182 Tc ( )Tj /F7 1 Tf 0.09595 0 Td -0.165 Tc ( )Tj /F8 1 Tf 0.08606 0 Td -0.164 Tc ( )Tj /F6 1 Tf 0.086 0 Td -0.182 Tc ( )Tj /F5 1 Tf 0.09595 0 Td 0 Tc ( )Tj ET endstream endobj 15 0 obj << /SA false /OPM 1 /Type/ExtGState /OP false >> endobj 16 0 obj << /SA false /OPM 1 /Type/ExtGState /OP true >> endobj 17 0 obj << /Length 4409 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 18 0 0 18 36 707.1504 Tm /CS0 cs 0.5 scn 0.028 Tw [(ADPKD Genes and Pr)18(oteins: What W)17(e Now Know)]TJ ET BT /F9 1 Tf 10 0 0 10 36 679.3835 Tm 0 0 0 1 k -0.0001 Tc 0.025 Tw (Jing Zhou, M.D, PhD)Tj 0 -1.2 TD 0 Tc [(H)1(a)1(r)-18(var)18(d Medical School, Boston, MA)]TJ ET BT /F10 1 Tf 10 0 0 10 36 643.3836 Tm 0.0251 Tw (The gene that is mutated in more than 85% of ADPKD patients is called \322PKD1.\323 The DNA sequence for PKD1 has)Tj 0 -1.2 TD 0.025 Tw [(been completely deter)-18(mined and, as a result, we have been able to identif)-19(y a large number of mutations that can)]TJ T* [(cause ADPKD. How these mutations cause the cysts that characterize ADPKD is now a subject of intense study)116(. The)]TJ 0 -1.19999 TD [(second ADPKD gene, PKD2, is responsible for approximately 15% of ADPKD cases. Lik)19(e PKD1, PKD2 has been)]TJ 0 -1.20001 TD 0.0001 Tc 0.0251 Tw (completely sequenced, and many mutations have been found. Genetic testing for ADPKD is now available using DNA)Tj 0 -1.2 TD 0 Tc (obtained from a single blood sample.)Tj 0 -2.39999 TD 0.0001 Tc (Once the ADPKD genes were identified and sequenced, it was possible to predict the sequence of the proteins, so-)Tj 0 -1.2 TD 0 Tc 0.025 Tw [(called polycystins, whose manufacture is directed by PKD1 and PKD2. Exploiting this new infor)-18(mation, scientists)]TJ 0 -1.19999 TD 0.0001 Tc 0.0251 Tw (immediately began to guess at the function of the polycystins and to devise experiments to test their hunches. In the)Tj 0 -1.2 TD (past three years, several breakthroughs have been made to enhance our understanding of how polycystins work and)Tj T* 0 Tc 0.025 Tw [(what goes wrong when they don\325t. As we understand these molecules better)56(, our ability to work toward a cure)]TJ 0.0251 Tw (becomes immeasurably enhanced.)' 0 -2.39999 TD 0.025 Tw [(ADPKD typically progresses over decades. Animal models of the disease will be impor)-18(tant for studying the progres-)]TJ 0 -1.2 TD 0.0001 Tc 0.0251 Tw (sion of the disease and will be valuable for testing potential therapies. Since the ADPKD genes were found, PKD)Tj 0 -1.19999 TD 0 Tc (researchers have been applying cutting-edge technology to generate animal models that mimic the human disease.)Tj 0 -1.2 TD (Several animal models of PKD1 and PKD2 mutations have been generated in the last five years. There are now knock-)Tj T* 0.025 Tw [(out \(the PKD genes have been knock)19(ed out of the animal!\) models for both PKD1 and PKD2 to star)-19(t testing different)]TJ 0 -1.19999 TD 0.0001 Tc 0.0251 Tw (strategies to slow or halt cyst enlargement and progression. )Tj 0 -2.4 TD 0 Tc 0.025 Tw [(The first real insight into the role played by polycystins in each cell came from the discover)-18(y of the function of a PKD)-37(-)]TJ 0 -1.19999 TD [(lik)18(e gene which scientists call PKDL. PKDL mak)19(es a protein, known as polycystin-L, which is ver)-19(y similar to)]TJ 0 -1.2 TD 0.0251 Tw (polycystin-2, the protein made by PKD2 protein. It was discovered that polycystin-L is a \322channel\323 through which)Tj (calcium\321and some other ions\321can move through cell membranes. It now tur)' 33.68459 0 TD 0.0001 Tc (ns out that polycystin-2 is also a)Tj -33.68459 -1.2 TD 0 Tc (channel that allows ions to travel through cell membranes.)Tj 0 -2.39999 TD (V)Tj 0.4917 0 TD 0.025 Tw [(er)-18(y recently)116(, scientists found that PKD1, which codes for a protein called polycystin-1, acts as a G)-18(-protein coupled)]TJ -0.4917 -1.2 TD [(receptor)56(. There is strong evidence that polycystin-1 and polycystin-2 are coupled to each other)55(. The next steps are to)]TJ 0 -1.19999 TD 0.0001 Tc 0.0251 Tw (figure out how these two proteins communicate with other proteins in the cell and with the world outside the cell.)Tj 0 -1.2 TD 0 Tc 0.025 Tw [(Understanding of these communications, called signaling networks, will be a k)19(ey to the search for molecules that)]TJ 0 -1.19999 TD 0.0008 Tc (dr)Tj 0.94409 0.00001 TD 0.0001 Tc 0.0251 Tw (ugs can target to halt the development of renal cysts and to treat ADPKD.)Tj ET /GS0 gs 1 w /CS0 CS 1 SCN 36 700.293 m 540 700.293 l S /GS2 gs BT /F0 1 Tf 9 0 0 9 468.6388 36.4268 Tm /CS0 cs 0.5 scn 0.2778 Tc 0.0278 Tw (Q&A on PKD)Tj 9.8731 0 Td 1 scn 0 Tc (5)Tj /F6 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tw ( )Tj /F8 1 Tf 0.27795 0 Td ( )Tj /F7 1 Tf ( )Tj /F6 1 Tf 0.50098 0 Td ( )Tj ET Q endstream endobj 18 0 obj << /Length 4796 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 18 0 0 18 72 707.1504 Tm /CS0 cs 0.5 scn -0.0001 Tc 0.0278 Tw (The Autosomal Recessive Polycystic Kidney Disease)Tj 0 -1.2 TD 0 Tc 0.028 Tw [((ARPKD) Gene and Pr)18(otein; What do we know?)]TJ ET BT /F9 1 Tf 10 0 0 10 72 657.7835 Tm 0 0 0 1 k 0.025 Tw [(P)56(eter C. Har)-19(ris, Ph.D)]TJ 0 -1.19999 TD [(Mayo Clinic, R)18(ochester)93(, MN)]TJ ET BT /F10 1 Tf 10 0 0 10 72 609.7836 Tm [(ARPKD is the infantile for)-18(m of polycystic kidney disease with the typical presentation of greatly enlarged cystic)]TJ 0 -1.2 TD [(kidneys diagnosed in utero or neonatally)116(. The disease can, however)56(, present later with less severe kidney disease and)]TJ 0 -1.20001 TD [(only become clinically relevant due to complications of fibrosis of the liver that invariably accompany the disorder)56(. )]TJ 0 -2.39999 TD (Genetic linkage studies indicate that ARPKD is caused by mutation to one gene, PKHD1, that is localized to chromo-)Tj 0 -1.2 TD 0.0001 Tc 0.0251 Tw (some region 6p12. ARPKD is a recessive disorder so a child is affected when they inherit one mutated copy of the)Tj T* 0 Tc 0.025 Tw [(gene from their mother and one from their father)56(. The disease is usually found in just one generation in the family)]TJ 0 -1.19999 TD 0.0251 Tw (and there is a one in four risk that a sibling of an ARPKD case will also be affected.)Tj 0 -2.4 TD 0.025 Tw [(The ARPKD gene, PKHD1, was identified by two separate research groups in 2002. W)79(e identified the gene using a rat)]TJ 0 -1.19999 TD 0.0001 Tc 0.0251 Tw (model, the PCK rat, that had arisen spontaneously in a few years earlier in Japan, and has progressive kidney and liver)Tj 0 -1.2 TD 0 Tc (cystic disease. Using a gene mapping approach we were able to show that PCK is a model of ARPKD and this led to a)Tj 0.0002 Tc (ver)' 1.33276 0 TD 0 Tc (y precise localization of the gene, highlighting one clear candidate. Mutation analysis in ARPKD patients \(and the)Tj -1.33276 -1.19999 TD 0.0001 Tc (PCK rat\) showed that this was the disease gene in humans and the rat model. The second group used the genetic)Tj 0 -1.2 TD 0 Tc (method of positional cloning in human ARPKD families and came to the same conclusion about the identity of the)Tj 0.0002 Tc (gene.)' 0 -2.39999 TD 0.0001 Tc (PKHD1 is an unusually large gene that covers nearly 500,000 base pairs of genomic DNA (0.017% of the DNA total))Tj 0 -1.2 TD (and encodes a large protein called fibrocystin. Mutation studies by many different groups have shown that multiple)Tj (different mutations cause ARPKD with over 250 different changes described in approximately 600 patients. This)' 0 -1.19999 TD 0 Tc 0.025 Tw [(complexity complicates molecular diagnostics but ser)-18(vices providing mutation based diagnostics are now available. It)]TJ 0 -1.2 TD 0.0001 Tc 0.0251 Tw (is clear that the combination of disease-causing changes influences the presentation with cases with two mutations)Tj T* 0 Tc 0.025 Tw [(that tr)-18(uncate the protein having the most severe disease. Cases with one or two substitution mutations of)-18(ten are less)]TJ 0 -1.19999 TD 0.0251 Tw (severely affected. However)Tj 11.61778 0 TD (, it is lik)Tj 3.30283 0 TD 0.0001 Tc (ely that environmental and other genetic factors also influence the presentation)Tj -14.92061 -1.20001 TD (and course of the disease.)Tj 0 -2.39999 TD (The precise role of the ARPKD protein, fibrocystin, is not yet known but, in common with many other PKD proteins,)Tj 0 -1.2 TD 0 Tc 0.025 Tw [(it has been localized to primar)-18(y cilia and the basal body in the renal epithelial cell. Primar)-19(y cilia \(that are rooted in)]TJ -0.0001 Tc 0.0251 Tw (the basal body\) are hair)' 10.01373 0.00001 TD -0.0003 Tc (-lik)Tj 1.27246 0.00001 TD 0.0001 Tc (e projections that extend from the sur)Tj 16.2856 0.00001 TD (face of cells lining tubules in the kidney and liver and)Tj -27.57179 -1.20001 TD 0 Tc 0.025 Tw [(are thought to have a sensor role, possibly detecting fluid flow)111(. The str)-18(ucture of fibrocystin suggests that it may sense)]TJ 0 -1.2 TD [(cues from the extracellular environment necessar)-18(y for proper development and maturation of renal and biliar)-18(y)]TJ 0.0001 Tc 0.0251 Tw (tubules. Studies are already under)' 14.7859 0.00001 TD (way to better understand the role of fibrocystin and use this knowledge to develop)Tj -14.7859 -1.20001 TD 0 Tc 0.025 Tw [(rational therapies to treat this devastating disorder)56(. )]TJ ET /GS0 gs 1 w /CS0 CS 1 SCN 72 676.195 m 576 676.195 l S /GS2 gs BT /F0 1 Tf 9 0 0 9 40.4999 36.4268 Tm /CS0 cs 1 scn 0.2777 Tc 0.0278 Tw (6 )Tj 2.001 0 Td 0.5 scn 0.2778 Tc (Q&A on PKD)Tj /F6 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F8 1 Tf 0.27795 0 Td ( )Tj /F7 1 Tf ( )Tj /F6 1 Tf 0.50098 0 Td ( )Tj ET Q endstream endobj 19 0 obj << /Length 6466 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 18 0 0 18 36 707.1504 Tm /CS0 cs 0.5 scn 0.028 Tw [(Strategies to T)92(r)18(eat Hypertension and End-organ Damage in)]TJ 0 -1.2 TD -0.0001 Tc 0.0278 Tw (ADPKD Patients)Tj ET BT /F9 1 Tf 10 0 0 10 36 657.7835 Tm 0 0 0 1 k 0 Tc 0.025 Tw [(Arlene Chapman MD, Emor)-37(y University School of Medicine)]TJ 0 -1.19999 TD [(A)-18(tlanta, GA)]TJ ET BT /F10 1 Tf 10 0 0 10 36 621.7836 Tm 0.0001 Tc 0.0251 Tw (Although ADPKD is an inherited disease, not all patients progress to end-stage renal disease in their lifetime.)Tj 0 -1.19999 TD 0 Tc 0.025 Tw (Approximately 50% of patients will begin dialysis or require a transplant in their sixth decade of life. The most impor-)Tj 0 -1.2 TD [(tant factors that deter)-18(mine if someone with ADPKD will progress to renal failure include being a man vs a woman, the)]TJ 0 -1.20001 TD [(PKD1 vs the PKD2 gene, and the presence of hyper)-18(tension. Given that gender and genotype cannot be modified,)]TJ 0 -1.19999 TD [(strategies for the best way to treat hyper)-18(tension in ADPKD have been tested and established.)]TJ 0 -2.4 TD [(New guidelines were set for)-18(th in 2001 by the High Blood Pressure Education Program at the National Hear)-18(t, Lung and)]TJ 0 -1.2 TD 0.0001 Tc 0.0251 Tw (Blood Institute at the National Institutes of Health regarding the appropriate blood pressure level for patients with all)Tj 0 -1.19999 TD 0 Tc 0.025 Tw [(types of renal disease, including ADPKD. Cur)-18(rent recommendations are for blood pressure to be k)18(ept to less than)]TJ 0 -1.20001 TD 0.0001 Tc 0.0251 Tw (125/75 mm Hg. These recommendations have been developed mostly for patients with renal disease with large)Tj 0 -1.2 TD 0 Tc 0.025 Tw [(amounts of protein in the urine. Impor)-18(tantly)116(, when protein is present in the urine in ADPKD patients, progress to)]TJ 0 -1.19999 TD [(renal failure tends to occur more quickly)116(. Although large amounts of protein in the urine do not happen ver)-18(y of)-18(ten in)]TJ 0 -1.2 TD [(ADPKD, it is reasonable to adopt these same blood-pressure goals when treating hyper)-18(tension in ADPKD. )]TJ 0 -2.39999 TD [(W)79(e know that a blood pressure-regulating system present in all people is activated more than usual in patients with)]TJ 0 -1.2 TD 0.0001 Tc 0.0251 Tw (ADPKD. This system is called the renin-angiotensin-aldosterone system. Even early)Tj 35.5715 0 TD 0 Tc (, when ADPKD patients still have)Tj -35.5715 -1.2 TD 0.025 Tw [(nor)-18(mal renal function, this system is tur)-18(ned on. When this happens, blood pressure rises of)-18(ten to hyper)-18(tensive)]TJ 0 -1.19999 TD 0.0001 Tc 0.0251 Tw (levels. As well, when this system is tur)Tj 16.17032 0 TD (ned on, it is more difficult for the kidney to get rid of salt in the diet, and blood)Tj -16.17032 -1.2 TD (pressure rises even more. Also, this system appears to promote cyst growth and expansion in animal models of PKD.)Tj T* 0 Tc 0.025 Tw [(So, for a variety of reasons, if this system were to be block)19(ed, it may be possible to slow or halt the progression of)]TJ 0.0001 Tc 0.0251 Tw (renal disease in ADPKD.)' 0 -2.39999 TD 0 Tc 0.025 Tw [(There are medicines that are indicated for the treatment of hyper)18(tension \(as well as congestive hear)-19(t failure and high)]TJ 0 -1.2 TD [(levels of protein in the urine\) that inter)-18(r)-19(upt the reninangiotensin-aldosterone system. There are two families of)]TJ 0 -1.19999 TD 0.0008 Tc (dr)Tj 0.94409 0 TD 0.0002 Tc 0.0251 Tw (ugs: one is the angiotensin conver)Tj 14.62623 0 TD 0 Tc 0.025 Tw [(ting enzyme inhibitor \(A)19(CE inhibitors\), and one is the angiotensin receptor)]TJ -15.57032 -1.20001 TD -0.0005 Tc (block)Tj 2.30127 0 TD 0.0001 Tc 0.0251 Tw (er (ARBs). A)Tj 5.43223 0 TD 0 Tc (CE inhibitors have been available and used for more than two decades and ARBs have been avail)Tj 41.04539 0 TD (-)Tj -48.77889 -1.20001 TD (able for approximately seven to eight years. Therefore, most of what we know about these medicines and successful)Tj 0 -1.19999 TD 0.025 Tw [(treatment of hyper)-18(tension in ADPKD is with the A)18(CE inhibitors. )]TJ 0 -2.4 TD (A)Tj 0.55542 0.00001 TD 0.0001 Tc 0.0251 Tw (CE inhibitors lower blood pressure in ADPKD patients, as do other antihyper)Tj 32.7883 0.00001 TD (tensive medications, but they also)Tj -33.34372 -1.2 TD 0 Tc 0.025 Tw [(improve blood flow to ADPKD kidneys. These salutor)-18(y effects are present in ADPKD patients who have tak)18(en medi)1(-)]TJ T* [(cine for as little as four hours and tested in patients who have tak)19(en the medicine for up to six weeks \(a ver)-19(y shor)-18(t)]TJ 0.0001 Tc 0.0251 Tw (period of time\). Given these positive results, A)' 20.09362 0.00001 TD 0 Tc (CE inhibitors should also help to slow or halt the rate of progression)Tj -20.09362 -1.20001 TD 0.025 Tw [(of renal disease in ADPKD \(a long-ter)-18(m effect\). )]TJ 0 -2.39999 TD [(However)56(, this long-ter)-18(m benefit or halting the progression of renal disease has not been demonstrated in three)]TJ 0 -1.2 TD [(different clinical studies in patients with ADPKD. Why is this? Is it because A)19(CE inhibitors really do not help ADPKD)]TJ 0 -1.19999 TD [(patients, or have the studies been car)-18(ried out inadequately? Most researchers believe the latter)55(. The studies have)]TJ 0 -1.2 TD [(been relatively shor)-18(t in duration (2.2-7 years) for a disease lik)18(e ADPKD and the number of patients studied \(64-222)]TJ 0.0001 Tc 0.0251 Tw (patients\) relatively small. As well, two of the three studies were tr)' 28.35241 0.00001 TD (ying to answer more than one question at the same)Tj -28.35241 -1.19999 TD 0 Tc 0.025 Tw [(time \(for example both the benefit of lower blood pressure targets and dietar)-18(y protein intak)18(e were being tested)]TJ 0 -1.2 TD [(simultaneously in one large study where A)19(CE inhibitors were used\). )]TJ 0 -2.4 TD [(Even so, with such a promising effect seen with shor)-18(t use of A)18(CE inhibitors, one should see some indication of its)]TJ 0 -1.2 TD [(benefit in long- ter)-18(m studies. This indeed has been demonstrated with regard to end-organ damage related to high)]TJ ET /GS0 gs 1 w /CS0 CS 1 SCN 36 675.8599 m 540 675.8599 l S /GS2 gs BT /F0 1 Tf 9 0 0 9 468.6388 36.4268 Tm /CS0 cs 0.5 scn 0.2778 Tc 0.0278 Tw (Q&A on PKD)Tj 9.8731 0 Td 1 scn 0 Tc (7)Tj /F6 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tw ( )Tj /F8 1 Tf 0.27795 0 Td ( )Tj /F7 1 Tf ( )Tj /F6 1 Tf 0.50098 0 Td ( )Tj ET Q endstream endobj 20 0 obj << /Length 6701 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F10 1 Tf 10 0 0 10 72 712.9834 Tm 0 0 0 1 k 0.025 Tw [(blood pressure in ADPKD. In studies that have been car)-18(ried out for up to 7 years, A)18(CE inhibitor benefit has been)]TJ 0 -1.2 TD 0.0001 Tc 0.0251 Tw (demonstrated in ADPKD patients with regard to reducing the level of protein in the urine and the size of the hear)Tj 48.52566 0.00001 TD 0 Tc (t)Tj -48.52566 -1.19999 TD 0.025 Tw [(\(lef)-18(t ventricular mass\). Long-standing hyper)-18(tension will result in increased thickness of the hear)-19(t muscle. This is)]TJ 0 -1.2 TD [(unhealthy and called lef)-18(t ventricular hyper)-19(trophy)117(. Not only do A)18(CE inhibitors reduce this enlarged hear)-18(t muscle back)]TJ T* [(to its nor)-18(mal size better than other antihyper)-18(tensive medications, but so does rigorous blood pressure control)]TJ 0 -1.19999 TD [((<125/85 mm Hg). As well, protein in the urine, which can be a mark)19(er of uncontrolled blood pressure, is reduced)]TJ 0 -1.2 TD [(to almost undetectable levels in ADPKD patients who receive A)19(CE inhibitors. Both of these findings indicate the)]TJ T* [(impor)-18(tance of A)18(CE inhibitors and most lik)19(ely blockade of the renin-angiotensin-system in preventing end-organ)]TJ 0 -1.20001 TD [(damage due to hyper)-18(tension in ADPKD patients. Bigger and longer studies are needed to deter)-18(mine if blockade of)]TJ 0 -1.19999 TD [(the renin-angiotensin-aldosterone system \(perhaps with additive therapies where A)19(CE inhibitors and ARBs are)]TJ 0 -1.2 TD 0.0001 Tc 0.0251 Tw (combined\) slows or halts the progression of renal disease in ADPKD patients. )Tj ET BT /F0 1 Tf 18 0 0 18 72 539.1508 Tm /CS0 cs 0.5 scn -0.0001 Tc (Diagnosis/Genetics)Tj 12 0 0 12 72 509.8341 Tm 1 scn 0 Tc 0.028 Tw [(What is a multicystic kidney? Ar)18(e multicystic and polycystic kidneys the same?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 484.984 Tm 0 0 0 1 k 0.025 Tw [(Multicystic kidneys differ from polycystic kidneys in a number of ways. They occur sporadically)116(, or happen by)]TJ 0 -1.2 TD [(chance, in the general population. Multicystic kidneys rarely appear as a nor)-18(mal kidney and are misshapen and)]TJ T* [(defor)-18(med. Even though kidneys enlarge in ADPKD and are cystic, the shape of a nor)-18(mal kidney is still apparent.)]TJ 0 -1.19999 TD 0.0001 Tc 0.0251 Tw (These are the differences that help to distinguish multicystic kidneys from polycystic kidneys. )Tj 0 -2.4 TD 0 Tc 0.025 Tw [(T)167(ypically)116(, multicystic kidney disease is diagnosed at or shor)-18(tly af)-19(ter bir)-18(th and occurs in one kidney only)116(. When multi-)]TJ 0 -1.19999 TD 0.0251 Tw (cystic kidneys occur in both kidneys (bilaterally), there is no kidney function, and the baby rarely sur)Tj 42.89817 0 TD 0.0001 Tc (vives. Multicystic)Tj -42.89817 -1.2 TD 0 Tc (kidneys are a consequence of abnor)Tj 15.33765 0 TD -0.0002 Tc (mal embr)Tj 4.0771 0 TD 0 Tc 0.025 Tw [(yonic development, where the blood supply is never a par)-18(t of the devel-)]TJ -19.41475 -1.20001 TD 0.0002 Tc 0.0251 Tw (oping kidney)Tj 5.4543 0 TD -0.0001 Tc (. )Tj -5.4543 -2.39999 TD 0.0001 Tc (My wife has been diagnosed as having fibrocystic breast disease. She has been involved in a study for at least 10 years)Tj 0 -1.2 TD 0 Tc (in Canada. I believe that 10-13,000 women have been a par)Tj 25.34103 0 TD 0.0002 Tc (t of this study)Tj 5.71226 0 TD 0.0001 Tc (. The protocol involves the ingestion of a)Tj -31.05329 -1.20001 TD (specific type of Iodine (a type that bypasses the thyroid). The results are staggering. The cysts are more or less)Tj 0 -1.19999 TD (deflated, thus reducing the pressure and discomfor)Tj 21.87154 0 TD (t associated with the disease. My question is this...is a cyst a cyst?)Tj -21.87154 -2.4 TD (By definition, a cyst is just a cyst. A cyst is a descriptive ter)Tj 24.99152 0 TD 0 Tc (m for a fluid-filled sac that is lined by a single layer of)Tj -24.99152 -1.19999 TD 0.0001 Tc (epithelium. The cysts seen in fibrocystic breast disease result from different pathways than the cysts seen in ADPKD.)Tj 0 -1.2 TD (However)Tj 3.76977 0.00001 TD (, the end result is the same, a cyst. Just as there are many different diseases responsible for cystic disease in)Tj -3.76977 -1.20001 TD 0 Tc 0.025 Tw [(the kidney)116(, such as tuberous sclerosis, chronic renal insufficiency)116(, dialysis, and von Hippel Lindau disease, there are)]TJ 0 -1.19999 TD [(other diseases responsible for cysts in other organs in the body)116(. )]TJ 0 -2.4 TD 0.0251 Tw (I have several simple cysts in my kidneys. What causes these cysts? Is there any treatment?)Tj 0 -1.19999 TD 0.025 Tw [(Simple kidney cysts develop in about 50 percent of individuals over the age of 50 years. They are not inherited lik)19(e)]TJ 0 -1.2 TD 0.0251 Tw (autosomal dominant PKD or autosomal recessive PKD, but develop from microscopic kidney tubules \(called)Tj T* 0.025 Tw [(nephrons\) in much the same way that hereditar)-18(y cysts for)-18(m. These tubule segments expand progressively and fill)]TJ 0.0001 Tc 0.0251 Tw (with fluid, and sometimes reach the size of a hen\325s eggs or oranges. They can be confused with renal tumors and)' 0 -1.19999 TD 0 Tc 0.025 Tw [(cancers, but they are other)-18(wise usually har)-19(mless. In some uncommon cases, it may be necessar)-18(y to operate on the)]TJ 0 -1.2 TD [(kidneys to r)-18(ule out cancers or remove an infected cyst, but in most cases no treatment is needed.)]TJ 0 -2.39999 TD [(Can PKD manifest itself in other ways? F)42(or instance, can a person have cysts in the liver or have some of the other)]TJ 0 -1.2 TD 0.0001 Tc 0.0251 Tw (PKD symptoms, but not have cysts in the kidneys themselves? Or can the cysts affect only one kidney?)Tj 0 -2.4 TD 0 Tc (There is a broad clinical spectr)Tj 13.02955 0.00001 TD 0.0001 Tc (um or phenotype to polycystic kidney disease. Some individuals have liver cystic)Tj -13.0296 -1.2 TD (disease as the main feature of their disease, and in some polycystic kidney disease is the predominant feature.)Tj T* 0 Tc 0.025 Tw [(However)56(, cystic disease of the kidneys is always present in ADPKD even when polycystic liver disease predominates.)]TJ 0.0001 Tc 0.0251 Tw (Other systemic or extra-renal manifestations of ADPKD include mitral valve prolapse, intracranial aneur)' 43.86174 0.00001 TD 0.0002 Tc (ysms, inguinal)Tj ET /GS0 gs 1 w /CS0 CS 1 SCN 72 531.883 m 576 531.883 l S /GS2 gs BT /F0 1 Tf 9 0 0 9 40.4999 36.4268 Tm /CS0 cs 1 scn 0.2777 Tc 0.0278 Tw (8 )Tj 2.001 0 Td 0.5 scn 0.2778 Tc (Q&A on PKD)Tj /F7 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj ET Q endstream endobj 21 0 obj << /Length 6664 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F10 1 Tf 10 0 0 10 36 712.9834 Tm 0 0 0 1 k 0.025 Tw [(or ventral her)-18(nias and polycystic ovaries. In ADPKD individuals, cysts can appear in one kidney only \(unilateral)]TJ 0 -1.2 TD 0.0001 Tc 0.0251 Tw (involvement\), usually when the individual is ver)Tj 20.33858 0.00001 TD (y young. This is frequently at the time of initial presentation.)Tj -20.33858 -1.19999 TD 0 Tc 0.025 Tw [(However)56(, invariably)116(, cystic involvement occurs in both kidneys. )]TJ 0 -2.4 TD 0.0251 Tw (There are families with polycystic liver disease without any evidence of polycystic kidneys affected by a separate)Tj 0 -1.19999 TD 0.025 Tw [(disease unrelated to ADPKD. P)42(olycystic liver disease without polycystic kidney disease is not caused by the same)]TJ 0 -1.2 TD [(mutation as PKD1 or PKD2. Just lik)19(e ADPKD, isolated polycystic liver disease is a dominantly inherited condition.)]TJ T* [(This means that each child of an affected individual has a 50:50, chance or the flip-of)19(-a-coin chance, of inheriting the)]TJ 0 -1.20001 TD 0.0001 Tc 0.0251 Tw (disease. The gene responsible for polycystic liver disease disorder has been located on chromosome 19. )Tj ET BT /F0 1 Tf 12 0 0 12 36 579.4338 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(Do all patients within a family suf)18(fering fr)17(om ADPKD develop r)18(enal failur)18(e at appr)17(oximately)]TJ 0 -1.19999 TD -0.0001 Tc 0.0278 Tw (the same time in the course of their disease?)Tj ET BT /F10 1 Tf 10 0 0 10 36 540.1838 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(ADPKD is a disease in which individuals within a family can demonstrate a wide range of disease severity)117(. Sometimes there)]TJ 0 -1.19999 TD 0.0251 Tw (are three generations of individuals alive: the grandparent is not on dialysis, doing well, while their offspring have reached)Tj 0 -1.2 TD 0.025 Tw [(ESRD or dialysis and their grandchildren are found at bir)-18(th to have advanced disease. This suggests that other genetic or)]TJ 0 -1.20001 TD [(environmental contributions besides the inherited gene are impor)18(tant with regard to progression of renal failure in)]TJ 0 -1.19999 TD 0.0251 Tw (ADPKD. These contributors could be other unrelated genes, or environmental factors or other second-hit processes)Tj 0 -1.2 TD ((mutations in the good copy of the PKD1 or PKD2 gene) that affect the kidneys in these individuals.)Tj ET BT /F0 1 Tf 12 0 0 12 36 442.6343 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (Is it possible that an appar)Tj 12.38111 0 TD (ent \322spontaneous onset\323 of ADPKD is due to a dormant gene)Tj -12.38111 -1.2 TD (in the family?)Tj ET BT /F10 1 Tf 10 0 0 10 36 403.3842 Tm 0 0 0 1 k 0 Tc 0.025 Tw [(Spontaneous mutations occur in the PKD1 and PKD2 genes. The chance of this occur)-18(ring is approximately 1 in)]TJ 0 -1.2 TD 0.0001 Tc 0.0251 Tw (10,000 in the PKD1 gene and even less frequently in the PKD2 gene. This does not mean the PKD gene mutation is)Tj 0 -1.19999 TD 0 Tc 0.025 Tw [(present in others in the family and lying \322dor)-18(mant\323 without a clinical diagnosis, but rather that, at the time of concep-)]TJ 0 -1.2 TD 0.0001 Tc 0.0251 Tw (tion, a mutation spontaneously occurs somewhere in the PKD gene leading to ADPKD. L)Tj 37.7423 0 TD 0.0003 Tc (ying dor)Tj 3.54854 0 TD 0 Tc (mant implies that)Tj -41.29084 -1.20001 TD (there is an affected parent with ADPKD. Such a situation can occur in par)Tj 31.49568 0 TD 0.0001 Tc (ticularly young affected individuals with no)Tj -31.49568 -1.2 TD (known family members with the disease. In this situation, when parents undergo screening for ADPKD, cysts are)Tj 0 -1.19999 TD (present in one of the parents. This situation indicates that the mutated gene was not dor)Tj 38.15671 0 TD 0.0002 Tc (mant but present and in an)Tj -38.15671 -1.2 TD 0.0001 Tc (affected parent not clinically diagnosed. )Tj ET BT /F0 1 Tf 12 0 0 12 36 281.8347 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(What ar)18(e the criteria for diagnosis of polycystic kidney disease in patients with negative)]TJ 0 -1.2 TD -0.0001 Tc 0.0278 Tw (family history?)Tj ET BT /F10 1 Tf 10 0 0 10 36 242.5846 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(P)23(arents of an individual with ADPKD should be screened with an ultrasound exam. If the ultrasound does not show renal)]TJ 0 -1.2 TD 0.0251 Tw (cysts, a computed tomographic (CT) or magnetic resonance (MR) exam has better resolution and can identif)Tj 45.00604 0.00001 TD -0.0149 Tc (y ver)Tj 1.98371 0.00001 TD -0.0152 Tc (y small)Tj -46.98975 -1.2 TD -0.015 Tc 0.025 Tw [(renal cysts in 5%. P)23(ater)-18(nity issues need to be addressed in ADPKD patients whose parents do not demonstrate evidence)]TJ 0.0251 Tw (of ADPKD. Given that a spontaneous mutation is responsible for approximately 15% of all ADPKD, there are individuals)' (with no other affected family members. In an ADPKD individual with a tr)' 30.14078 0.00001 TD (uly negative family histor)Tj 10.24879 0.00001 TD 0.025 Tw [(y)116(, the minimum)]TJ -40.38957 -1.20001 TD [(number of cysts required for a diagnosis is five in each kidney)116(. This number is slightly more than the number of cysts)]TJ 0 -1.2 TD [(required to mak)19(e a diagnosis in young at-risk individuals for whom a parent with ADPKD has been identified. In addition,)]TJ T* [(other manifestations of ADPKD should be sought af)-18(ter)56(, including liver cystic disease, mitral valve prolapse, inguinal)]TJ -0.0152 Tc (her)' 1.40891 0.00001 TD -0.015 Tc 0.0251 Tw (nias or intracranial aneur)Tj 10.22584 0.00001 TD -0.0149 Tc (ysms. F)Tj 3.25976 0.00001 TD -0.015 Tc (or example, hepatic fibrosis, a feature of ARPKD, is rarely seen in ADPKD and can be)Tj -14.89451 -1.20001 TD 0.025 Tw [(used to distinguish different cystic disorders. Impor)-18(tantly)116(, renal enlargement is a feature of ADPKD only and not a feature)]TJ 0 -1.2 TD [(of another inherited cystic disorder)56(. Solid tumors are found in the kidneys of patients with von Hippel Lindau and)]TJ 0.0251 Tw (tuberous sclerosis and are not found in ADPKD. These are the clues that help to distinguish ADPKD from other inherited)' T* 0.025 Tw [(cystic diseases of the kidney)116(. A)19(f)-19(ter careful clinical characterization, if there is still doubt, mutation detection can be used)]TJ T* [(to confir)-18(m the presence of ADPKD. )]TJ ET BT /F0 1 Tf 9 0 0 9 468.6388 36.4268 Tm /CS0 cs 0.5 scn 0.2778 Tc 0.0278 Tw (Q&A on PKD)Tj 9.8731 0 Td 1 scn 0 Tc (9)Tj /F7 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tw ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj /F7 1 Tf 0.27802 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj ET Q endstream endobj 22 0 obj << /Length 6310 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 12 0 0 12 72 711.4336 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (Now that both autosomal PKD genes have been isolated, will it be possible to determine if)Tj 0 -1.2 TD 0 Tc 0.028 Tw [(a fetus has the disease? How early in the pr)18(egnancy can testing be done?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 672.1835 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Y)117(es, it is possible to deter)-18(mine if a fetus has the disease. T)134(esting can be done if properly planned, and a center where this)]TJ 0 -1.2 TD 0.0251 Tw (is available prenatally or at 5-8 weeks gestation. Not only have both PKD genes been isolated, but mutation-detection)Tj 0 -1.19999 TD -0.0151 Tc (strategies have been developed that work for PKD1, PKD2 and ARPKD (PKHD) as well. The accuracy of the mutation-)Tj 0 -1.2 TD -0.0149 Tc (detection strategies differ between the two ADPKD gene types, with mutation-detection strategies being the most)Tj T* -0.015 Tc 0.025 Tw [(accurate in PKD2 individuals. Close to a 90% mutation-detection rate is obser)-18(ved in PKD2. In PKD1, mutations are)]TJ 0 -1.19999 TD 0.0251 Tw (successfully identified in approximately 65-70%. The lower success rate in PKD1 is because the gene is larger and more)Tj 0 -1.2 TD 0.025 Tw [(difficult to analyze, given the long polypyrimidine tract. Additionally)116(, pieces of the gene so similar to PKD1 lie nearby on)]TJ 0.0251 Tw (the same chromosome that it is difficult to separate the pieces from the PKD1 gene. The ARPKD gene has been identified)' 0 -1.19999 TD 0.025 Tw [(in 2002 and mutations found; however)56(, it is too early to tell the best way to screen all individuals for mutations in ARPKD)]TJ 0 -1.20001 TD 0.0251 Tw (and the success rate of mutation detection.)Tj ET BT /F0 1 Tf 12 0 0 12 72 526.6341 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(W)18(ould the diagnosis \322medullary sponge kidney\323 be the same as or part of polycystic)]TJ 0 -1.2 TD -0.0001 Tc 0.0278 Tw (kidney disease?)Tj ET BT /F10 1 Tf 10 0 0 10 72 487.384 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Medullar)-18(y sponge kidney is common and occurs in 1:100 to 1:200 individuals. The diagnosis is only a radiological one. It)]TJ 0 -1.2 TD [(is characterized by the presence of dilated or enlarged collecting tubules in the medulla or middle of the kidney)117(. This)]TJ T* [(occurs in many unrelated kidney disorders and has been repor)-18(ted to occur in ADPKD. The cause of medullar)-18(y sponge)]TJ 0 -1.19999 TD [(kidney is not entirely understood but in ADPKD is probably secondar)18(y to the distor)-18(tion of the collecting system by the)]TJ 0 -1.2 TD [(presence of cysts in that area of the kidney)116(. Medullar)-18(y sponge kidney increases the risk of renal stone disease, probably)]TJ T* [(from alterations in urinar)-18(y flow and may)116(, in par)-18(t, account for the high frequency of renal stone disease \(approximately)]TJ 0 -1.19999 TD -0.0149 Tc 0.0251 Tw (25%\) in ADPKD individuals. )Tj ET BT /F0 1 Tf 12 0 0 12 72 377.8344 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(I am a 36-year)55(-old woman, diagnosed with PKD at age 22. Except for high blood pr)17(es-)]TJ 0 -1.19999 TD [(sur)18(e and a full abdomen, I have no symptoms. Neither of my par)17(ents had this disease;)]TJ 0 -1.2 TD [(both wer)18(e tested. No other r)17(elatives have PKD. I assumed that I have the r)18(ecessive form)]TJ 0 -1.19999 TD [(of PKD. How rar)18(e is it for someone to have r)17(ecessive disease and live past childhood?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 309.7844 Tm 0 0 0 1 k (Y)Tj 0.43244 0 TD -0.015 Tc 0.025 Tw [(ou may or may not have autosomal recessive polycystic kidney disease (ARPKD). Y)116(ou could also have a for)-18(m of auto-)]TJ -0.43244 -1.19999 TD 0.0251 Tw (somal dominant polycystic kidney disease (ADPKD) that is due to a spontaneous mutation. This typically occurs in 15% of)Tj 0 -1.2 TD (ADPKD patients, which is in approximately 1:10,000 individuals. Given that ARPKD occurs in 1:20,000 individuals, it is)Tj -0.0152 Tc (twice as lik)' 4.45682 0.00001 TD -0.0151 Tc (ely that you have ADPKD. However)Tj 14.77039 0.00001 TD -0.015 Tc (, ARPKD can present in childhood or in adulthood. The two for)Tj 26.34617 0.00001 TD -0.0149 Tc (ms of pres)Tj 4.31605 0.00001 TD 0 Tc (-)Tj -49.88943 -1.20001 TD -0.015 Tc (entation are different, with adults having signs and symptoms related more to liver disease or congenital hepatic fibrosis.)Tj 0 -1.2 TD 0.025 Tw [(This is not a cystic for)-18(m of liver disease but a dilated for)-18(m of the bile ducts of the liver)56(. The kidneys in ARPKD are rarely)]TJ 0.0251 Tw (large, and this helps to differentiate between ADPKD and ARPKD. The signs and symptoms of liver disease related to)' T* 0.025 Tw [(ARPKD can be serious and life-threatening and include bleeding from the stomach and infection in the liver)56(. The best)]TJ 0 -1.19999 TD [(non-invasive way to tell if you have ARPKD is to undergo a magnetic resonance angiography with cholangiography)117(. This)]TJ 0 -1.2 TD [(will deter)-18(mine non-invasively if congenital hepatic fibrosis is present and also deter)-18(mine the relative size and cystic)]TJ 0.0251 Tw (involvement of the liver and kidneys. )' 0 -2.39999 TD 0.025 Tw [(There is a strong patter)-18(n of PKD in my family)116(. A)19(t age 18, I was told \(af)-19(ter kidney X)75(-rays\) that I did not have PKD. There is)]TJ 0 -1.2 TD 0.0251 Tw (confusion in our family about who will and who will not have this disease later in life, even if an initial exam proved nega)Tj 49.55077 0.00001 TD 0 Tc (-)Tj -49.55077 -1.19999 TD -0.015 Tc (tive, as in my case. I am 28 years old. )Tj 0 -2.4 TD 0.025 Tw [(PKD has a variable age of onset, but, in general, most patients with the adult for)-18(m of PKD will show X)74(-ray signs at age 18,)]TJ 0 -1.2 TD 0.0251 Tw (even if they have no symptoms. The standard dye test (IVP) that you probably had is the least sensitive of the tests now)Tj -0.0153 Tc (available. )' ET BT /F0 1 Tf 9 0 0 9 40.4983 37.7027 Tm /CS0 cs 1 scn 0.2778 Tc 0.0278 Tw (10 )Tj 2.8349 0 Td 0.5 scn (Q&A on PKD)Tj /F6 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj ET Q endstream endobj 23 0 obj << /Length 6403 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F10 1 Tf 10 0 0 10 36 712.9834 Tm 0 0 0 1 k -0.0149 Tc 0.0251 Tw (In most centers, ultrasound (sonography) is sensitive enough to detect most cases of PKD, but not sensitive enough, in)Tj 0 -1.2 TD -0.015 Tc (the view of most specialists, to completely exclude the diagnosis. The computed tomography (CT scan) combined with)Tj 0 -1.19999 TD 0.025 Tw [(the dye infusion is the most sensitive test available. If)38(, at age 28, you have a negative sonogram and CT scan, cur)-18(rent data)]TJ 0 -1.2 TD 0.0251 Tw (indicates that you do not have PKD and will not pass it on. )Tj ET BT /F0 1 Tf 12 0 0 12 36 639.4338 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(Is either race or ethnic backgr)18(ound a factor in the development of the disease? Ar)17(e all)]TJ 0 -1.2 TD [(races af)18(fected equally?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 600.1837 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(ADPKD occurs with equal frequency in all races and genders. There is no difference in how of)-18(ten ADPKD occurs in popu-)]TJ 0 -1.2 TD [(lations whether they are Japanese, Caucasian, A)19(frican American or Mexican. It is not clear yet whether disease severity)]TJ 0 -1.19999 TD [(differs in different races. It has been suggested the disease severity is greater in Japanese and A)19(frican Americans as)]TJ 0 -1.20001 TD [(compared to their Caucasian counterpar)-18(ts. However)56(, the data to suppor)-18(t this are less than complete. A)18(frican Americans)]TJ -0.0151 Tc 0.0251 Tw (with ADPKD and a poor renal outcome also have sickle cell disease, which can affect renal function independent of)' 0 -1.2 TD -0.015 Tc 0.025 Tw [(ADPKD. When large groups are reviewed with regard to age of onset of dialysis, A)19(frican Americans do not appear to be)]TJ 0 -1.19999 TD [(different from their Caucasian counterpar)-18(ts. Small studies suggest that A)19(frican American patients with ADPKD are diag-)]TJ 0 -1.2 TD [(nosed with hyper)-18(tension an earlier age than their Caucasian counterpar)-18(ts and have higher ser)-18(um creatinine values,)]TJ 0 -1.20001 TD [(suggesting worse disease. However)56(, creatinine levels are greater in A)19(frican Americans with the same level of renal func-)]TJ 0 -1.19999 TD [(tion as Caucasians. Cur)-18(rently)116(, it is difficult to say if ADPKD is more severe in A)19(frican Americans than Caucasians.)]TJ ET BT /F0 1 Tf 12 0 0 12 36 452.2343 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (Why do people in the same family vary in the intensity and manifestations of PKD?)Tj ET BT /F10 1 Tf 10 0 0 10 36 427.3841 Tm 0 0 0 1 k -0.02 Tc 0.025 Tw [(This question has not yet been answered fully)116(. There are a number of explanations, however)56(. It is now known that the)]TJ 0 -1.19999 TD [(cysts in patients with ADPKD not only have an inherited PKD1 or PKD2 mutation but that they also have an acquired muta)1(-)]TJ 0 -1.2 TD [(tion in the PKD1 or PKD2 gene inherited from the unaffected parent. In up to 70% of all cyst cells, this \322second hit\323 tak)19(es)]TJ 0.0251 Tw (place. This suggests that cysts in ADPKD kidneys and livers not only have an inherited gene but also have a mutation, in)' 0 -1.19999 TD (the non-inherited PKD gene. Given that the second hit, or somatic mutation, is a random event \(this could occur at age 1,)Tj 0 -1.2 TD (5, 15, 45, etc.\), this introduces a lot of variability into how a disease expresses itself within a family)Tj 39.48365 0 TD (. This is one possible)Tj -39.48365 -1.2 TD (cause. The second cause is that other genes are also contributing to disease severity in ADPKD. F)Tj 39.91502 0 TD -0.0201 Tc (or example, a high blood)Tj -39.91502 -1.2 TD -0.02 Tc (pressure gene or a diabetes gene or a cancer gene may be in the same family as the ADPKD gene, and, when combined,)Tj 0 -1.19999 TD (the disease is more severe in that individual and not in another family member with ADPKD who did not inherit both genes)Tj 0 -1.2 TD -0.0199 Tc (together)Tj 3.42257 0 TD -0.02 Tc 0.025 Tw [(. F)19(inally)115(, environmental exposures are impor)-18(tant risk factors for progression of many different renal diseases. It is)]TJ -3.42257 -1.2 TD [(possible that toxic occupational exposures are impor)-18(tant risk factors for progression of renal disease in ADPKD. These risks)]TJ 0 -1.19999 TD [(have not been evaluated or established in the disease variability found in ADPKD but are wor)-18(th considering.)]TJ ET BT /F0 1 Tf 12 0 0 12 36 257.8348 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (If PKD is such a common her)Tj 13.55758 0 TD (editary kidney disease, why is it that I have talked to only)Tj -13.55758 -1.2 TD (one person who actually has the disease, and everyone else I have talked to has never)Tj (hear)' 2.01977 0 TD -0.0002 Tc (d of it?)Tj ET BT /F10 1 Tf 10 0 0 10 36 204.1846 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (Good question! One of the mysteries of PKD is why so few have ever heard of this condition. It is much more common)Tj 0 -1.2 TD (than cystic fibrosis, sickle cell anemia and Down\325s syndrome, conditions that Americans are much more aware of than)Tj 0 -1.19998 TD -0.0152 Tc (PKD. Y)Tj 3.01969 0.00001 TD -0.0149 Tc (our question affir)Tj 7.11814 0.00001 TD -0.015 Tc (ms one of the impor)Tj 8.51509 0.00001 TD (tant goals of the PKD F)Tj 9.45063 0.00001 TD (oundation, which is to increase the awareness of PKD)Tj -28.10355 -1.20002 TD (among laypersons. )Tj ET BT /F0 1 Tf 12 0 0 12 36 130.6351 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (I have PKD, but my sister does not have it. She is inter)Tj 25.64147 0 TD (ested in genetic counseling, and)Tj -25.6415 -1.2 TD (her question is: Can PKD skip a generation? )Tj ET BT /F10 1 Tf 10 0 0 10 36 91.385 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (If your sister is more than 25 years of age and does not have cysts in the kidneys and/or the liver when examined by)Tj 0 -1.2 TD 0.025 Tw [(computed tomography scan (CT scan) with contrast enhancement, it is most unlik)19(ely that she has PKD. There are no)]TJ ET BT /F0 1 Tf 9 0 0 9 461.134 36.4268 Tm /CS0 cs 0.5 scn 0.2778 Tc 0.0278 Tw (Q&A on PKD)Tj 9.8731 0 Td 1 scn (11)Tj /F7 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj /F7 1 Tf 0.27802 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj /F7 1 Tf 0.27802 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj ET Q endstream endobj 24 0 obj << /Length 6638 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F10 1 Tf 10 0 0 10 72 712.9834 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (documented instances to our knowledge that PKD has skipped a generation. In other words, if your sister does not have)Tj 0 -1.2 TD (PKD at age 25, there is ver)Tj 10.85199 0.00001 TD (y little chance that her offspring will have the disease, provided, of course, that her husband)Tj -10.85199 -1.19999 TD (does not have PKD. )Tj ET BT /F0 1 Tf 12 0 0 12 72 651.4338 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(I understand that ther)18(e is a blood test for all family members of a PKD patient to deter)-1(-)]TJ 0 -1.2 TD -0.0001 Tc 0.0278 Tw (mine who else in the family has PKD and/or to determine which family member is a)Tj T* 0 Tc 0.028 Tw [(potential donor)92(. Please pr)17(ovide mor)18(e information about the test. )]TJ ET BT /F10 1 Tf 10 0 0 10 72 597.7836 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(A test is commercially available that depends on the linkage of PKD to a mark)19(er known to occur on chromosome 16 or 4.)]TJ 0 -1.20001 TD 0.0251 Tw (This is called gene-linkage analysis. There are also mutation-detection strategies now available. In order for the test to be)Tj 0 -1.19999 TD 0.025 Tw [(infor)-18(mative, one must have one, and preferably)116(, two or more living family members available who have the disease in)]TJ 0 -1.2 TD [(order to deter)-18(mine which asymptomatic subjects in the family have the PKD gene. If you are interested in being tested,)]TJ T* [(you can contact the genetics depar)-18(tment of medical schools in your area, or you can write to the National Center for)]TJ T* [(Education in Mater)-18(nal and Child Health, 3520 Prospect St., N.W)209(., W)79(ashington, D.C., 20057 and request a copy of its)]TJ 0 -1.19999 TD [(pamphlet entitled \322Comprehensive Clinical Genetic Ser)-18(vices Centers: A National Director)-18(y)116(.\323 This is a listing of genetic)]TJ 0 -1.20001 TD [(ser)-18(vice centers throughout the United States, which provide comprehensive diagnostic ser)-18(vices, medical management,)]TJ 0 -1.2 TD 0.0251 Tw (counseling and follow-up care. )Tj ET BT /F0 1 Tf 12 0 0 12 72 464.2342 Tm /CS0 cs 1 scn -0.0002 Tc 0.0278 Tw (My mother has polycystic kidneys, as does my sister)Tj 24.46788 0 TD -0.0001 Tc (. I have a polycystic liver)Tj 11.65304 0 TD (, and one)Tj -36.12093 -1.2 TD 0 Tc 0.028 Tw [(polycystic kidney was r)18(emoved because of infection. The r)17(emaining kidney is O.K. Do I)]TJ -0.0001 Tc 0.0278 Tw (have PKD, since only one kidney seems to be involved? )' ET BT /F10 1 Tf 10 0 0 10 72 410.5842 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (In view of the strong family histor)Tj 13.87088 0 TD (y and the evidence of cysts in the liver and one kidney)Tj 22.23023 0 TD (, there seems to be little doubt)Tj -36.10111 -1.20001 TD (that you have the hereditar)Tj 11.20829 0 TD -0.0149 Tc (y for)Tj 1.87482 0 TD -0.0151 Tc (m of PKD. There are a few repor)Tj 13.68673 0 TD -0.015 Tc (ts of \322one-sided\323 PKD in the medical literature, but these)Tj -26.76984 -1.20001 TD (are extremely rare. A CT scan of the remaining kidney would resolve the issue. )Tj ET BT /F0 1 Tf 12 0 0 12 72 349.0345 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (Do you believe that it is possible for me to be the only child of nine who has PKD?)Tj ET BT /F10 1 Tf 10 0 0 10 72 324.1844 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(In each child of an affected parent, autosomal dominant polycystic kidney disease is a 50/50 proposition. It is lik)19(e flipping)]TJ 0 -1.2 TD [(pennies. Occasionally three, four)56(, or five or more heads will tur)-18(n up in a row)111(. If one flips the pennies a sufficient number)]TJ 0 -1.19999 TD [(of times, the odds will always even out\32150 percent heads, 50 percent tails. Many families seem to have a lopsided experi)1(-)]TJ 0 -1.2 TD 0.0251 Tw (ence with polycystic kidney disease. In your case, it is a low statistical probability that you are the only one of nine)Tj T* 0.025 Tw [(children who has the disease, but not an impossibility)116(. W)79(e have communicated with other families in which nearly all of)]TJ 0.0251 Tw (the members seem to have polycystic kidney disease and only a few escaped without it. Large-scale studies of many PKD)' 0 -1.19999 TD 0.025 Tw [(families have always confir)-18(med the 50/50 ratio. )]TJ ET BT /F0 1 Tf 12 0 0 12 72 214.6348 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(Though the gene of polycystic kidney disease is autosomal dominant, isn\325)18(t ther)17(e occa-)]TJ 0 -1.2 TD -0.0001 Tc 0.0278 Tw (sionally incomplete penetrance?)Tj ET BT /F10 1 Tf 10 0 0 10 72 175.3848 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (In dominantly inherited diseases, 50 percent of the offspring of an affected parent may inherit the defective gene. If the)Tj 0 -1.2 TD (disease is dominant, then it should be seen in all patients who have the defective gene. In a number of studies \(done by)Tj -0.0148 Tc (per)' 1.40671 0.00001 TD (for)Tj 1.17868 0.00001 TD -0.015 Tc (ming radiographic studies on all patients at risk for PKD whether they had symptoms of the disease or not\), ADPKD)Tj -2.58539 -1.20001 TD (has been clearly shown to be an autosomal dominant condition. Incomplete penetrance is a ter)Tj 39.52891 0.00001 TD (m used to describe a)Tj -39.52891 -1.20001 TD 0.025 Tw [(genetic disorder that does not always show up in ever)-18(y sequential generation of a family)116(. Incompletely penetrant genes)]TJ T* [(cause the par)-18(ticular disease to \322skip\323 generations. ADPKD appears to \322skip\323 generations in some families, but incomplete)]TJ 0.0251 Tw (penetrance is not the reason why)' 13.62413 0.00001 TD -0.0149 Tc (. If sensitive radiographic tests are not per)Tj 17.51439 0.00001 TD -0.015 Tc 0.025 Tw [(for)-18(med, some subjects who have the ADPKD)]TJ -31.1385 -1.2 TD [(gene and a mild for)-18(m of the disease may never become aware that they have it. They can, however)56(, pass the gene on to)]TJ T* [(their offspring, and it may resur)-18(face there. Thus, because ADPKD has mild for)-18(ms of presentation in some individuals, it)]TJ -0.0151 Tc 0.0251 Tw (has incor)' 3.7748 0 TD -0.015 Tc (rectly been grouped by some doctors among incompletely penetrant genetic disorders. )Tj ET BT /F0 1 Tf 9 0 0 9 40.4999 36.4268 Tm /CS0 cs 1 scn 0.2778 Tc 0.0278 Tw (12 )Tj 2.8349 0 Td 0.5 scn (Q&A on PKD)Tj /F7 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj /F7 1 Tf 0.27802 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj /F7 1 Tf 0.27802 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj ET Q endstream endobj 25 0 obj << /Length 6954 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 12 0 0 12 36 711.4336 Tm /CS0 cs 1 scn 0.028 Tw [(Y)92(ou indicate in PKD updates that a milder form of PKD exists. I would like to know if a)]TJ 0 -1.2 TD [(nephr)18(ologist can or)17(der a test to determine which form of PKD an individual has?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 672.1835 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(T)167(wo genetic types of autosomal dominant PKD are now recognized. PKD)-36(-1 affects the vast majority (85%) of individuals)]TJ 0 -1.2 TD [(who have polycystic kidneys. Another genetic for)-18(m, now called PKD)-37(-2, appears to have a milder clinical course than PKD)-37(-)]TJ 0 -1.19999 TD -0.0151 Tc 0.0251 Tw (1 (at least 14%). There is a genetic test available for the PKD)Tj 24.97199 0.00001 TD -0.015 Tc 0.025 Tw [(-1 and PKD)-37(-2 type, either through gene-linkage analysis,)]TJ -24.97199 -1.20001 TD 0.0251 Tw (which requires at least two affected individuals in the family along with the individual who is at risk. As well, mutation-)Tj 0 -1.2 TD 0.025 Tw [(detection strategies are available. These tests are per)-18(for)18(med at only a few centers scattered throughout the United States. )]TJ ET BT /F0 1 Tf 18 0 0 18 36 570.3506 Tm /CS0 cs 0.5 scn 0 Tc 0.028 Tw [(Extrar)18(enal Manifestations)]TJ ET BT /F10 1 Tf 10 0 0 10 36 542.5838 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(My wife has just found out she has congenital hepatic fibrosis. Is there any cure for this condition? W)79(e have not been)]TJ 0 -1.19999 TD [(able to find out much on this condition and would lik)19(e to know more.)]TJ 0 -2.4 TD [(Congenital hepatic fibrosis is a pathological diagnosis of the liver in which fibrotic tissue sur)-18(rounds the biliar)-18(y ducts. The)]TJ 0 -1.19999 TD [(cause of this is due to an abnor)-18(mality during embr)-18(yogenesis when the ductal plates of the liver are for)-18(med. This condi-)]TJ 0 -1.20001 TD [(tion can occur in isolation or in association with cystic diseases of the kidney)116(, most commonly in autosomal recessive)]TJ 0 -1.2 TD 0.0251 Tw (polycystic kidney disease. R)Tj 11.58368 0 TD -0.0152 Tc (arely)Tj 1.82433 0 TD -0.015 Tc 0.025 Tw [(, congenital hepatic fibrosis has been repor)-18(ted to occur in association with autosomal)]TJ -13.40801 -1.2 TD [(dominant polycystic kidney disease. The biliar)-18(y ducts of the liver become dilated and defor)-18(med. The ducts can appear)]TJ 0 -1.19999 TD [(cystic. Because of these changes, the bile ducts are prone to developing stones or infection. The liver becomes progres)1(-)]TJ 0 -1.2 TD 0.0251 Tw (sively worse over time, and the fibrosis results in ultimate failure of the liver or cir)Tj 33.53002 0 TD -0.0149 Tc (rhosis with por)Tj 6.23511 0 TD -0.0151 Tc (tal hyper)Tj 3.63463 0 TD -0.0149 Tc (tension. These)Tj -43.39976 -1.20001 TD -0.015 Tc (changes result in other complications, including varices of the esophagus. V)Tj 31.34631 0 TD -0.0151 Tc (arices can cause bleeding from the stomach)Tj -31.34631 -1.19999 TD -0.015 Tc (and the esophagus, which is a life-threatening condition. V)Tj 24.0163 0 TD (arices may require medication, banding of the esophagus, and)Tj -24.0163 -1.2 TD (eventually)Tj 4.02879 0 TD (, transplantation of the liver)Tj 11.29518 0 TD -0.0151 Tc (. )Tj ET BT /F0 1 Tf 12 0 0 12 36 361.0345 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (What is known about pancr)Tj 12.74103 0 TD (eatic cysts in patients with autosomal dominant polycystic)Tj -12.74103 -1.2 TD 0 Tc 0.028 Tw [(kidney disease (ADPKD)? How often do they occur)92(, and what symptoms do they cause?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 321.7844 Tm 0 0 0 1 k (P)Tj 0.48469 0 TD -0.015 Tc 0.0251 Tw (ancreatic cysts are repor)Tj 9.97773 0 TD (ted to occur in ADPKD. They occur in approximately 11% of ADPKD patients. T)Tj 32.78896 0 TD -0.0152 Tc (ypically)Tj 2.88656 0 TD -0.0151 Tc (, they are)Tj -46.13794 -1.20001 TD -0.015 Tc (solitar)Tj 2.50929 0 TD 0.025 Tw [(y)116(, and it is unusual to find multiple pancreatic cysts in ADPKD patients. If multiple pancreatic cysts are present, the)]TJ -2.50929 -1.19999 TD [(possibility of other diagnoses should be raised, including von Hippel Lindau disease. P)24(ancreatic cysts in ADPKD have not)]TJ 0 -1.2 TD [(been repor)-18(ted to cause clinical problems and have been incidental diagnoses made during ultrasound, computed tomog-)]TJ 0.0251 Tw (raphy or magnetic resonance imaging examination. P)' 21.80262 0.00001 TD (ancreatic cysts have not been found to cause abnor)Tj 21.09085 0.00001 TD (malities in)Tj -42.89347 -1.2 TD (pancreatic function or pancreatic inflammation. )Tj ET BT /F0 1 Tf 12 0 0 12 36 224.2348 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(Ar)18(e patients with ADPKD mor)17(e likely to have diverticulosis? What is the dif)18(fer)18(ence)]TJ 0 -1.19999 TD -0.0001 Tc 0.0278 Tw (between diverticulosis and diverticulitis?)Tj ET BT /F10 1 Tf 10 0 0 10 36 184.9846 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Diver)-18(ticulosis has been repor)-18(ted to occur in ADPKD individuals with increased frequency)116(. Diver)-18(ticulosis is an out)]TJ 0 -1.19999 TD [(pouching of the wall of the intestine. The intestines are the bowels that car)-18(r)-18(y food and help with digestion. Diver)-18(ticuli)]TJ 0 -1.2 TD [(usually develop in the large bowel towards the end of the digestive system. They look lik)19(e grapes or pouches attached to)]TJ T* [(the wall of the intestine. These pouches have nar)-18(row necks where they attach to the bowel or intestine. Sometimes)]TJ 0 -1.19999 TD [(these necks become block)19(ed, and this results in inflammation or diver)-18(ticulitis. This is a painful condition, and patients)]TJ 0 -1.2 TD 0.0251 Tw (usually have abdominal pain, fever and sometimes constipation associated with it. This condition may require the use of)Tj T* 0.025 Tw [(antibiotics to heal properly)116(. The way to avoid diver)18(ticulosis becoming diver)-18(ticulitis is to k)19(eep your bowel regimen as)]TJ 0.0251 Tw (regular as possible and to avoid episodes of constipation. As many as 70% of dialysis patients with ADPKD have diver)' 48.20813 0.00001 TD -0.0151 Tc (tic)Tj 0.97873 0.00001 TD 0 Tc (-)Tj -49.1869 -1.2 TD -0.0149 Tc (ular disease, and it has been suggested but not proven that ADPKD patients with diver)Tj 35.55841 0.00001 TD (ticular disease suffer from)Tj -35.5584 -1.2 TD -0.015 Tc 0.025 Tw [(complications such as diver)-18(ticulits or r)-18(upture of a diver)18(ticuli more of)-18(ten than patients without ADPKD. )]TJ ET /GS0 gs 1 w /CS0 CS 1 SCN 36 564.4999 m 540 564.4999 l S /GS2 gs BT /F0 1 Tf 9 0 0 9 461.1341 36.4268 Tm /CS0 cs 0.5 scn 0.2778 Tc 0.0278 Tw (Q&A on PKD)Tj 9.8731 0 Td 1 scn (13)Tj /F6 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj ET Q endstream endobj 26 0 obj << /Length 6674 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 12 0 0 12 72 711.4336 Tm /CS0 cs 1 scn 0.028 Tw [(Is ther)18(e a r)17(elationship between malabsorption of food and nutrients in the GI tract and)]TJ 0 -1.2 TD -0.0001 Tc 0.0278 Tw (polycystic kidney disease?)Tj ET BT /F10 1 Tf 10 0 0 10 72 672.1835 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(There is no direct relationship between malabsorption of food and nutrients and polycystic kidney disease. However)56(, in)]TJ 0 -1.2 TD [(patients with ver)-18(y large kidneys or livers, compression of the gastrointestinal system can occur that then results in diffi)1(-)]TJ 0 -1.19999 TD 0.0251 Tw (culty with digestion of food. This is a for)Tj 16.81059 0.00001 TD (m of malabsorption that is related to polycystic kidney disease. )Tj ET BT /F0 1 Tf 12 0 0 12 72 610.6339 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (What is polycystic liver disease (PLD)? Can someone have PLD without having PKD?)Tj ET BT /F10 1 Tf 10 0 0 10 72 585.7836 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(P)42(olycystic liver disease is defined by the presence of multiple cysts in the liver)56(. Liver cysts are present in the majority of)]TJ 0 -1.19999 TD [(ADPKD patients, and the frequency of these occur)-18(ring increases with age. Hepatic cysts have been repor)-18(ted to present)]TJ 0 -1.2 TD [(approximately 10 years af)-18(ter renal cysts appear in ADPKD. W)79(omen and men are equally affected; however)56(, liver cysts)]TJ T* [(appear earlier and more severely in women. Estrogen exposure in the for)-18(m of pregnancy and bir)-18(th-control pill use have)]TJ T* [(been shown to increase the lik)19(elihood that liver cysts will develop in ADPKD women. PLD has been repor)-18(ted to occur in)]TJ 0 -1.19999 TD 0.0251 Tw (individuals without evidence of polycystic kidney disease. This disease is not caused by genes than cause ADPKD and)Tj 0 -1.2 TD 0.025 Tw [(should be considered a separate disorder)56(. Impor)-18(tantly)116(, polycystic liver disease found in ADPKD and polycystic liver)]TJ 0.0251 Tw (disease in isolation do not usually result in liver failure. )' ET BT /F0 1 Tf 12 0 0 12 72 464.2342 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (What information exists about the r)Tj 16.34229 0 TD (elationship between her)Tj 11.11172 0 TD (nias and polycystic kidneys? I)Tj -27.45402 -1.2 TD 0 Tc 0.028 Tw [(am a female who was diagnosed with an inguinal her)-18(nia at age 18 but was not diagnosed)]TJ T* [(with PKD until age 24. I was wondering if the her)-18(nia was a r)18(esult of the PKD. )]TJ ET BT /F10 1 Tf 10 0 0 10 72 410.5842 Tm 0 0 0 1 k -0.015 Tc (Her)Tj 1.58029 0 TD 0.0251 Tw (nias are found in increased frequency in ADPKD. The her)Tj 23.60435 0 TD (nias are typically inguinal or ventral. The reason for this)Tj -25.18464 -1.20001 TD -0.0151 Tc (association has not been well work)Tj 14.34156 0 TD -0.015 Tc (ed out. It is most lik)Tj 8.47231 0 TD -0.0151 Tc (ely both a developmental er)Tj 11.53837 0 TD -0.015 Tc 0.025 Tw [(ror and an abnor)-18(mality in extracellular)]TJ -34.35224 -1.20001 TD [(matrix. W)79(omen are not as lik)19(ely as men to develop her)19(nias, so the presence of a her)-18(nia in a young woman with ADPKD)]TJ 0 -1.19999 TD 0.0251 Tw (suggests that this is a result of a mutation in the ADPKD gene. )Tj ET BT /F0 1 Tf 12 0 0 12 72 337.0346 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(I am a 44-year)55(-old woman with polycystic kidney and liver disease. I have heartbur)-18(n, and)]TJ 0 -1.2 TD [(my physician or)18(der)17(ed x-rays of the stomach, which showed that I have a hiatal her)-18(nia. Is)]TJ -0.0001 Tc 0.0278 Tw (the hiatal her)' 6.07388 0 TD 0 Tc 0.028 Tw [(nia r)18(elated to polycystic kidney disease?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 283.3845 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Hiatal her)-18(nias are ver)-19(y common in the general population. However)56(, hiatal her)-18(nias have been found in ADPKD individ-)]TJ 0 -1.19999 TD 0.0251 Tw (uals with increased frequency)Tj 12.05492 0.00001 TD (, par)Tj 1.85626 0.00001 TD (ticularly those with polycystic liver involvement. P)Tj 20.36893 0.00001 TD -0.0151 Tc (olycystic livers can become quite large)Tj -34.28011 -1.20001 TD -0.015 Tc (and cause compression of the stomach. It is most lik)Tj 21.8566 0.00001 TD -0.0152 Tc (ely that the hiatal her)Tj 8.76415 0.00001 TD -0.015 Tc (nias develop as a result of the pressures caused)Tj -30.62075 -1.20001 TD (by the presence of polycystic liver disease. This is usually a benign condition and will get better with early evening meals,)Tj 0 -1.2 TD (sleeping with two or more pillows, and using medication to reduce the acidity of the stomach.)Tj ET BT /F0 1 Tf 12 0 0 12 72 197.8349 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (I am a patient with PKD, and I have had a kidney transplant. I also have polycystic liver)Tj 0 -1.2 TD 0 Tc 0.028 Tw [(disease. What ar)18(e the r)17(easons that I should avoid estr)18(ogens, and what is the latest)]TJ 0 -1.19999 TD [(r)18(esear)18(ch about estr)17(ogens in polycystic liver disease?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 144.1848 Tm 0 0 0 1 k (P)Tj 0.46614 0.00001 TD -0.015 Tc 0.0251 Tw (olycystic liver disease is aggravated by increased exposures to estrogen. Pregnancy number and bir)Tj 40.49152 0.00001 TD (th-control pill use are)Tj -40.95766 -1.20001 TD (associated with the presence of polycystic liver disease. P)Tj 23.64279 0.00001 TD (ost-menopausal estrogen replacement therapy has been demon)Tj 26.28733 0.00001 TD 0 Tc (-)Tj -49.93012 -1.20001 TD -0.015 Tc (strated to be associated with increases in liver cystic volume, parenchymal volume and total liver volume as compared to)Tj (ADPKD women not receiving hor)' 13.8078 0.00001 TD (mone replacement therapy)Tj 11.07316 0.00001 TD (. These changes were seen over a one-year time period. One)Tj -24.881 -1.2 TD (way to avoid high estrogen exposures in the liver is to tak)Tj 23.66802 0.00001 TD -0.0149 Tc (e estrogen if necessar)Tj 8.89596 0.00001 TD (y in a der)Tj 3.84116 0.00001 TD -0.0151 Tc (mal deliver)Tj 4.54541 0.00001 TD -0.015 Tc (y system or as a skin)Tj -40.9506 -1.2 TD 0.025 Tw [(patch. This tends to avoid high liver estrogen exposures af)-18(ter absorption of estrogen pill use (called the first-pass effect))]TJ ET BT /F0 1 Tf 9 0 0 9 40.4999 36.4268 Tm /CS0 cs 1 scn 0.2778 Tc 0.0278 Tw (14 )Tj 2.8349 0 Td 0.5 scn (Q&A on PKD)Tj /F6 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj ET Q endstream endobj 27 0 obj << /Length 6118 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F10 1 Tf 10 0 0 10 36 712.9834 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(and may reduce the effect on progression of polycystic liver disease. The use of estrogen af)-18(ter renal transplantation in)]TJ 0 -1.2 TD -0.0149 Tc 0.0251 Tw (which prednisone use may diminish bone density)Tj 20.34701 0.00001 TD -0.015 Tc 0.025 Tw [(, is an impor)-18(tant issue. Estrogen is clearly effective in maintaining bone)]TJ -20.34701 -1.19999 TD -0.0149 Tc 0.0251 Tw (density in post-menopausal women. )Tj ET BT /F0 1 Tf 12 0 0 12 36 651.4338 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(I am a 46-year)55(-old white male whose father died as a r)17(esult of r)18(enal failur)18(e. I was diag-)]TJ 0 -1.2 TD -0.0001 Tc 0.0278 Tw (nosed with polycystic kidneys at the age of 30 and subsequently found to have a cystic)Tj T* 0 Tc 0.028 Tw [(liver)92(, and my right testicle is gr)17(ossly enlarged due to cysts. Do you have any information)]TJ T* [(on cysts involving the testicular r)18(egion in polycystic kidney disease patients?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 583.3837 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Cysts in the testicular region have been repor)-18(ted in patients with ADPKD. The cysts are located in the seminal vesicle,)]TJ 0 -1.19999 TD [(which is in the scrotum adjacent to the testicle. If these cysts are in a specific position, they can stop sper)-18(m from traveling)]TJ 0 -1.2 TD 0.0251 Tw (from the testicle to the prostate, where they can then be available for reproduction. If this occurs, and it is rare, those)Tj T* 0.025 Tw [(individuals can be infer)-18(tile. If this is the case, this can be cor)-18(rected surgically)116(, or sper)-18(m can be obtained indirectly to be)]TJ 0 -1.19999 TD [(made available for fer)-18(tilization. Overall, men with ADPKD do not have a decline in fer)-18(tility)116(, and their sper)-18(m appear to be)]TJ 0 -1.2 TD [(nor)-18(mal. Therefore, if a case lik)19(e this occurs, even though it is related to ADPKD, it is not ver)-18(y common.)]TJ ET BT /F0 1 Tf 12 0 0 12 36 485.8342 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (I am a 48-year)Tj 6.60459 0 TD (-old man with ADPKD. I have a very large abdomen and have been told that)Tj -6.60459 -1.2 TD 0 Tc 0.028 Tw [(my polycystic kidneys ar)18(e particularly large. My r)17(enal function is only slightly r)18(educed. My)]TJ T* [(concer)-18(n is that, during the last two years, I have experienced episodes of vomiting shortly)]TJ 0 -1.19999 TD -0.0001 Tc 0.0278 Tw (after eating. Except for this, my health has been good. I don\325)Tj 28.17917 0 TD (t feel particularly ill befor)Tj 11.48492 0 TD -0.0002 Tc (e or)Tj -39.66409 -1.2 TD -0.0001 Tc (after vomiting. My physician has run some tests, but no obvious explanation has been)Tj 0 -1.19999 TD 0 Tc 0.028 Tw [(found. Could my vomiting episodes be r)18(elated to PKD?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 388.9842 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (There are many causes for vomiting that are not related to ADPKD. Stomach ulcers, gastritis, reflux and even medications)Tj 0 -1.19999 TD (can cause vomiting. As well, systemic illnesses such as diabetes mellitus or post transplantation can be associated with)Tj 0 -1.2 TD 0.025 Tw [(abnor)-18(malities in gastrointestinal function that results in vomiting. W)19(ith that said, given that your doctor has been thor-)]TJ -0.0149 Tc 0.0251 Tw (ough and r)' 4.55922 0 TD -0.015 Tc (uled out these problems, there are situations where either polycystic livers or polycystic kidneys become big)Tj -4.55922 -1.2 TD (enough that the stomach becomes compressed. When this occurs, patients usually feel one of two things. Either they)Tj 0 -1.19999 TD (develop early satiety)Tj 8.22309 0 TD (, which means they lose their appetite or can only eat small amounts of food and then feel full, or they)Tj -8.22309 -1.2 TD (have episodes of post-prandial \(af)Tj 13.8836 0 TD 0.025 Tw [(ter meal\) vomiting. This usually occurs soon af)-18(ter eating, within 30 minutes, and can)]TJ -13.8836 -1.20001 TD 0.0251 Tw (include undigested food. The treatment for this is not complete but can include medications to help in gastric motility or)Tj 0 -1.19999 TD (stomach emptying, changing meal patter)Tj 16.81967 0.00001 TD (ns to more frequent meals with smaller amounts, changing the position with)Tj -16.81967 -1.20001 TD (eating to lie on the right side to help with stomach emptying and consideration for cyst-reduction procedures to help)Tj 0 -1.2 TD (reduce compression on the stomach.)Tj ET BT /F0 1 Tf 12 0 0 12 36 231.4348 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(A few years ago at a Friends seminar)92(, a PKD r)17(esear)18(cher said that PKD is becoming)]TJ 0 -1.19999 TD -0.0001 Tc 0.0278 Tw (thought of as a disease of the connective tissue, rather than just a kidney disease. I)Tj 0 -1.2 TD 0 Tc 0.028 Tw [(haven\325)18(t seen much about this in the PKD Foundation literatur)17(e. Did I misunderstand what)]TJ T* [(I hear)18(d?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 163.3848 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(No, you heard this cor)-18(rectly)116(. The role of the PKD genes is complicated, but it appears that one of the functions of these)]TJ 0 -1.2 TD 0.0251 Tw (two genes is to allow for communication between different cell types on the extra-cellular matrix. This component of)Tj 0 -1.19999 TD -0.0149 Tc (tissue in the body is par)Tj 9.81747 0.00001 TD -0.015 Tc (t of the connective tissue and may play an impor)Tj 20.02255 0.00001 TD -0.0149 Tc (tant role in the pathogenesis of disease in)Tj -29.84002 -1.20001 TD -0.015 Tc 0.025 Tw [(ADPKD. In suppor)-18(t of this, inguinal and ventral her)-18(nias, which are disorders of connective tissue, have been found with)]TJ 0.0251 Tw (increased frequency in ADPKD individuals.)' ET BT /F0 1 Tf 9 0 0 9 461.1341 36.4268 Tm /CS0 cs 0.5 scn 0.2778 Tc 0.0278 Tw (Q&A on PKD)Tj 9.8731 0 Td 1 scn (15)Tj /F7 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj /F7 1 Tf 0.27802 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj ET Q endstream endobj 28 0 obj << /Length 6634 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 12 0 0 12 72 711.4336 Tm /CS0 cs 1 scn 0.028 Tw [(I am 50 years old and have polycystic kidney disease. For some time now)55(, I have been)]TJ 0 -1.2 TD -0.0001 Tc 0.0278 Tw (complaining of continuous ringing in the ears. My physician has made a diagnosis of)Tj 0 -1.19999 TD (tinnitus. Can this be a manifestation of an intracranial aneurysm?)Tj ET BT /F10 1 Tf 10 0 0 10 72 657.7835 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(T)51(innitus is usually not associated with intracranial aneur)18(ysms. The causes of tinnitus are local and in the area of the audi)1(-)]TJ 0 -1.19999 TD [(tor)-18(y canals next to the ears. T)167(ypically)116(, the symptoms associated with intracranial aneur)-18(ysms include headaches, change in)]TJ 0 -1.2 TD [(vision or functional neurological loss. However)56(, intracranial aneur)-18(ysms that are symptomatic can present in many)]TJ T* [(different fashions, and so one cannot r)-18(ule out with cer)-18(tainty that tinnitus is not related. The way to mak)19(e sure that an)]TJ 0 -1.19999 TD [(intracranial aneur)-18(ysm is not present is to have a magnetic resonance angiogram of the brain per)-18(for)-18(med. This test can)]TJ 0 -1.2 TD [(detect even small intracranial aneur)-18(ysms. )]TJ ET BT /F0 1 Tf 12 0 0 12 72 560.2339 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (Is a brain cyst part of autosomal dominant polycystic kidney disease?)Tj ET BT /F10 1 Tf 10 0 0 10 72 535.3839 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Cysts have been repor)-18(ted in the brain with increased frequency in polycystic kidney disease patients \(usually in 3-5% of)]TJ 0 -1.2 TD 0.0251 Tw (patients\). These cysts are usually in the pineal region, are incidental findings and do not cause trouble to patients. The)Tj T* 0.025 Tw [(protein polycystin, which is produced by the ADPKD gene, is found in ver)-18(y high concentrations in the brains of patients)]TJ T* [(with ADPKD. Whether this accounts for the cysts found in the brains of ADPKD patients is unclear)56(. )]TJ ET BT /F0 1 Tf 12 0 0 12 72 461.8342 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(My mother and her br)18(other had PKD, and both had ruptur)17(ed brain artery aneurysms in)]TJ 0 -1.19999 TD -0.0001 Tc 0.0278 Tw (their 50s. I am 42. Should I have an X-ray test for brain aneurysms?)Tj ET BT /F10 1 Tf 10 0 0 10 72 422.5841 Tm 0 0 0 1 k -0.015 Tc (Cur)Tj 1.52829 0 TD 0.0251 Tw (rent estimates indicate that, in the absence of any symptoms, the risk of a PKD patient having an aneur)Tj 42.31782 0 TD (ysm is between)Tj -43.84611 -1.2 TD -0.0149 Tc (5 and 10 percent. Aneur)Tj 10.20534 0 TD -0.0148 Tc (ysms tend to r)Tj 5.91248 0 TD -0.015 Tc (un in families. Cur)Tj 7.79422 0 TD -0.0149 Tc (rent studies suggest that there are no compelling reasons to)Tj -23.91204 -1.20001 TD -0.015 Tc (screen all persons with PKD for aneur)Tj 15.57659 0 TD (ysm; however)Tj 5.65633 0 TD (, if there is a family histor)Tj 10.37606 0 TD 0.025 Tw [(y of aneur)-18(ysm, screening by angio magnetic)]TJ -31.60898 -1.20001 TD [(resonance imaging (MRI) is indicated. P)23(atients with PKD who note a change in symptoms involving the head region)]TJ 0 -1.19999 TD (\(blur)Tj 2.04308 0 TD 0.0251 Tw (red vision, dizziness, severe headache\) should consult their physician.)Tj ET BT /F0 1 Tf 12 0 0 12 72 337.0346 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (Can you please tell us symptoms of aneurysms of the brain and abdomen?)Tj ET BT /F10 1 Tf 10 0 0 10 72 324.1844 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Aneur)-18(ysms (ballooning) of brain blood vessels will occasionally cause recur)-18(rent, severe headaches. P)23(atients have also)]TJ 0 -1.2 TD [(repor)-18(ted eye disturbances, nausea, vomiting, and stiff neck. F)42(or)-18(tunately)116(, aneur)-18(ysm of the brain vessels is relatively)]TJ 0 -1.19999 TD [(uncommon. The aneur)-18(ysms tend to occur within families of patients who have polycystic kidney disease. W)79(e all have)]TJ 0 -1.2 TD 0.0251 Tw (headaches from time to time, so longstanding \322nagging\323 headache should not be a wor)Tj 35.91867 0.00001 TD 0 Tc (r)Tj 0.36652 0.00001 TD -0.015 Tc (y to patients with polycystic)Tj -36.28519 -1.20001 TD (kidney disease. On the other hand, a PKD patient with a new type of headache that is unrelenting should seek medical)Tj 0 -1.2 TD 0.025 Tw [(attention. Aneur)-18(ysms in the abdominal blood vessels usually occur in the aor)-18(ta, the major blood vessel r)-18(unning through)]TJ 0 -1.19999 TD [(the body just in front of the spinal column. P)24(atients will occasionally notice an \322extra hear)-19(tbeat\323 in the upper abdomen)]TJ 0 -1.2 TD [(when an aneur)-18(ysm is present. These types of aneur)-18(ysms can also cause pain in the abdomen of a nonspecific nature. It is)]TJ T* [(relatively easy to check for abdominal aneur)-18(ysm with a sonogram test to exclude this as a cause for abdominal pain. )]TJ ET BT /F0 1 Tf 12 0 0 12 72 190.6348 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(I am a PKD patient on dialysis. T)111(wo weeks befor)17(e my kidneys failed, I had a str)18(oke. The)]TJ 0 -1.19999 TD [(CT scan showed an intracer)18(ebral (brain) hemorrhage but no aneurysm. I know about PKD)]TJ 0 -1.2 TD [(and cer)18(ebral aneurysms, but I wonder if ther)17(e is a connection between PKD and intracer)18(e-)]TJ -0.0001 Tc 0.0278 Tw (bral vessel weakness?)' ET BT /F10 1 Tf 10 0 0 10 72 122.5849 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Individuals with high blood pressure, whether they have PKD or not, have a higher incidence of intracerebral hemor)-18(rhage)]TJ 0 -1.2 TD 0.0251 Tw (than those who do not have elevated blood pressure. Since more than onehalf of polycystic kidney patients have elevated)Tj T* 0.025 Tw [(blood pressure, there may be an increased incidence of strok)19(e due to intracerebral hemor)-18(rhage that is not related to)]TJ T* [(aneur)-18(ysm for)-18(mation. There is no infor)-18(mation to indicate that the blood vessels of polycystic kidney patients are inher-)]TJ T* [(ently weak)19(er than nor)-19(mal. Thus, intracerebral hemor)-18(rhage in a PKD patient with nor)-18(mal blood pressure should raise the)]TJ T* [(question of an occult cerebral aneur)-18(ysm. )]TJ ET BT /F0 1 Tf 9 0 0 9 40.4999 36.4268 Tm /CS0 cs 1 scn 0.2778 Tc 0.0278 Tw (16 )Tj 2.8349 0 Td 0.5 scn (Q&A on PKD)Tj /F6 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj ET Q endstream endobj 29 0 obj << /Length 6374 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 12 0 0 12 36 711.4336 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (Once an aneurysm has been found, how successful is surgical intervention?)Tj ET BT /F10 1 Tf 10 0 0 10 36 686.5835 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Not all intracranial aneur)-18(ysms require surger)-18(y)116(. While aneur)-19(ysms causing symptoms should be treated immediately)117(, the)]TJ 0 -1.2 TD [(recommendation for surger)-18(y in the case of incidental, asymptomatic aneur)-18(ysms will depend on the estimated risk of)]TJ 0 Tc (r)' 0.36653 0.00001 TD -0.015 Tc [(upture if lef)-18(t untreated and the risk of surger)-18(y)116(. These risks are deter)-18(mined by the number)55(, size and location of the)]TJ -0.36653 -1.2 TD [(aneur)-18(ysms, the age of the patient, and the exper)-18(tise of the neurosurgeon. In good hands, the average incidental intracra-)]TJ T* [(nial aneur)-18(ysm can be repaired with a less-than 5 percent risk of dying or having major complications. )]TJ ET BT /F0 1 Tf 12 0 0 12 36 601.0339 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(W)18(e have hear)18(d of patients with PKD who have ruptur)17(ed cer)18(ebral aneurysms. My husband)]TJ 0 -1.2 TD [(has PKD and is 65 years old and on dialysis. His sister died of a ruptur)18(ed aneurysm at)]TJ 0 -1.19999 TD [(age 32. W)18(e have thr)17(ee childr)18(en ages 24-33, and the oldest has PKD. What if anything,)]TJ 0 -1.2 TD -0.0001 Tc 0.0278 Tw (should we do?)Tj ET BT /F10 1 Tf 10 0 0 10 36 532.9839 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(It does not appear necessar)-18(y to look for aneur)-18(ysms in ever)18(y person with PKD, since it seems that aneur)-18(ysms are not ver)18(y)]TJ 0 -1.2 TD [(common in PKD. There has been a suggestion that aneur)-18(ysms may occur in some PKD families and not in others.)]TJ 0 -1.20001 TD 0.0251 Tw (Because of this, some doctors might suggest that only PKD patients in such families, or PKD patients who would cause a)Tj 0 -1.19999 TD 0.025 Tw [(high risk to others if an aneur)-18(ysm r)-18(uptured and they became unconscious \(lik)19(e an airplane pilot\), should be studied for)]TJ 0 -1.2 TD [(aneur)-18(ysms. Ruptured aneur)-18(ysms don\325t seem to happen ver)18(y of)-18(ten in PKD patients on dialysis. The tests available to look)]TJ T* [(for aneur)-18(ysms include ar)-18(teriography)116(, computed tomography)116(, and the new technique of magnetic resonance angiography)116(.)]TJ 0.0251 Tw (This last test appears to be the easiest and the best.)' ET BT /F0 1 Tf 12 0 0 12 36 423.4343 Tm /CS0 cs 1 scn -0.017 Tc 0.028 Tw [(My 38-year)55(-old sister has been diagnosed as having two fluid-filled arachnoid cysts in the)]TJ 0 -1.19999 TD [(lining of the brain. A CT scan and MRI wer)18(e used to confirm the diagnosis. The doctors)]TJ 0 -1.2 TD [(don\325)18(t know if these cysts ar)17(e associated with PKD. Do you have any information about this?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 369.7843 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Arachnoid cysts have indeed been detected by CT scan in several patients with polycystic kidney disease. V)79(er)-18(y little is)]TJ 0 -1.2 TD 0.0251 Tw (known about how these cysts in the brain may affect patients. In the experience of a few nephrologists, these cysts have)Tj T* 0.025 Tw [(been asymptomatic, and no treatment was recommended. There is ver)18(y little experience in the management of these)]TJ 0 -1.19999 TD 0.0251 Tw (cysts. Should a patient develop symptoms that neurologists and neurosurgeons agree may be caused by an arachnoid)Tj 0 -1.2 TD -0.0149 Tc (cyst, direct inter)Tj 6.62156 0 TD -0.015 Tc (vention may be indicated.)Tj ET BT /F0 1 Tf 12 0 0 12 36 284.2346 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(I am a 39-year)55(-old man with polycystic kidney disease. My father and two br)17(others, also)]TJ 0 -1.2 TD -0.0001 Tc 0.0278 Tw (with PKD, had heart attacks befor)Tj 15.71363 0 TD (e the age of 50. Is ther)Tj 10.75308 0 TD -0.0002 Tc (e any r)Tj 3.14981 0 TD -0.0001 Tc (elation between PKD and)Tj -29.61653 -1.20001 TD 0 Tc 0.028 Tw [(an incr)18(eased risk for heart attacks? What can I do to r)17(educe my risk?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 230.5846 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (The most common cause of death in all patients with renal failure, including ADPKD, is cardiovascular death. This is most)Tj 0 -1.19999 TD 0.025 Tw [(l)1(i)1(k)19(ely due to a combination of the presence of hyper)18(tension, the pro-inflammator)-18(y state of renal insufficiency)116(, and abnor-)]TJ 0 -1.2 TD [(malities in lipid metabolism found in patients with all types of renal disease. Hyper)-18(tension occurs early in ADPKD, prior to)]TJ 0.0251 Tw (the loss of renal function. It occurs, on average, a decade earlier than the hyper)' 32.88464 0.00001 TD -0.0149 Tc (tension found in the general population.)Tj -32.88464 -1.2 TD -0.015 Tc 0.025 Tw [(Hyper)-18(tension is an impor)-18(tant risk factor for the progression of renal disease in ADPKD and is associated with the pres-)]TJ T* [(ence of lef)-18(t ventricular hyper)-18(trophy)116(, which is an independent risk factor for cardiovascular death. Aggressive control of)]TJ T* [(hyper)-18(tension in ADPKD is helpful in reversing the presence of lef)-18(t ventricular hyper)-18(trophy)116(, par)-18(ticularly with the use of)]TJ -0.0149 Tc (angiotensin-conver)' 7.83918 0.00001 TD -0.015 Tc 0.0251 Tw (ting enzyme inhibitors. One way to reduce cardiovascular risk if you have ADPKD is to monitor your)Tj -7.83918 -1.19999 TD 0.025 Tw [(blood pressure closely)116(, and, if you have high blood pressure needing treatment, to have a blood pressure goal of less than)]TJ 0 -1.2 TD [(125/75 mm Hg. This monitoring will help prevent organ damage \(lef)18(t ventricular hyper)-18(trophy\) related to hyper)-18(tension)]TJ 0.0251 Tw (and probably reduce the rate of progressive loss of renal function in ADPKD. If these goals are met, your cardiovascular)' T* 0.025 Tw [(risk will decline significantly)116(.)]TJ ET BT /F0 1 Tf 9 0 0 9 461.1341 36.4268 Tm /CS0 cs 0.5 scn 0.2778 Tc 0.0278 Tw (Q&A on PKD)Tj 9.8731 0 Td 1 scn (17)Tj /F6 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj ET Q endstream endobj 30 0 obj << /Length 6084 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 12 0 0 12 72 711.4336 Tm /CS0 cs 1 scn 0.028 Tw [(What happens to the adr)18(enal glands, which sit on top of the kidneys, when the kidneys)]TJ 0 -1.2 TD [(become enlarged in PKD? Do the kidneys push on the glands and make them excr)18(ete)]TJ 0 -1.19999 TD 0 Tw [(adr)18(enaline?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 657.7835 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (The adrenal glands do not appear large when viewed by computed tomography in ADPKD. Although they rest on top of)Tj 0 -1.19999 TD 0.025 Tw [(the kidneys, the cystic expansion of the polycystic kidney does not inter)-18(fere with the adrenal gland. However)56(, of interest,)]TJ 0 -1.2 TD [(one of the hor)-18(mones, aldosterone, made in excess quantities, results in high blood pressure and protein in the urine.)]TJ 0.0251 Tw (Some, but not all, studies suggest that aldosterone levels may be elevated in ADPKD patients. )' ET BT /F0 1 Tf 12 0 0 12 72 584.2338 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(I have PKD, and my cysts ar)18(e small. The only pr)17(oblem I have associated with my disease)]TJ 0 -1.19999 TD [(is high blood pr)18(essur)17(e. I take Benazepril (10 mg) for high blood pr)18(essur)18(e. I want to quit)]TJ 0 -1.2 TD [(smoking, but can I take Zyban \(bupr)18(opion\) to help me stop smoking?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 530.5839 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(There is no contraindication to taking Benazepril and Zyban together)56(. In addition, Zyban is not contraindicated in)]TJ 0 -1.2 TD [(patients with polycystic kidney disease. High doses of Zyban can increase blood pressure, so it is impor)-18(tant to mak)19(e sure)]TJ T* [(that your doctor is involved as you use this medication. Most impor)18(tantly)116(, the health benefits of quitting smoking far)]TJ 0 -1.19999 TD [(outweigh the risks of polycystic kidney disease in someone lik)19(e yourself)37(, where the disease appears to be ver)-18(y mild.)]TJ ET BT /F0 1 Tf 12 0 0 12 72 457.0342 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(I am in the military)92(, am 41 years old, and have PKD. I am taking Benazepril for high blood)]TJ 0 -1.19999 TD -0.0003 Tc (pr)Tj 0.94482 0 TD -0.0002 Tc (essur)Tj 2.50147 0 TD 0 Tc [(e. I am also taking the Depo-Pr)18(overa shot for birth contr)17(ol. My doctor has told)]TJ -3.44629 -1.2 TD [(me that I should stop taking the shot, because it may raise blood pr)18(essur)17(e. I do not plan)]TJ 0 -1.19999 TD [(on having childr)18(en, and he suggests that I have a tubal ligation since I don\325)17(t want any)]TJ 0 -1.2 TD -0.0002 Tc 0.0278 Tw (other birth-contr)Tj 7.60152 0 TD -0.0001 Tc (ol method. Does the Depo-Pr)Tj 13.89918 0 TD -0.0002 Tc (overa shot incr)Tj 6.90957 0 TD 0 Tc 0.028 Tw [(ease blood pr)18(essur)17(e? Will)]TJ -28.41026 -1.20001 TD -0.0001 Tc 0.0278 Tw (having the tubal ligation interfer)Tj 14.68731 0 TD (e with my PKD?)Tj ET BT /F10 1 Tf 10 0 0 10 72 360.1843 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Depo-Provera has been repor)-18(ted to be associated with increases in blood pressure as well as edema and swelling.)]TJ 0 -1.2 TD [(However)56(, high blood pressure is a relatively uncommon side effect of Depo-Provera. Depo-Provera is a long-acting prog-)]TJ 0 -1.19999 TD 0.0251 Tw (esterone that suppresses ovulation. The advantage of Depo-Provera is that one does not have to remember to tak)Tj 47.02005 0 TD -0.0152 Tc (e a pill)Tj -47.02005 -1.2 TD -0.015 Tc 0.025 Tw [(ever)-18(y day)116(. The other choices for bir)-18(th control include diaphragm and sper)-18(micidal jelly)116(, daily bir)-19(th control pill use or tubal)]TJ T* [(ligation. T)139(ubal ligation has no special effect on women with ADPKD. )]TJ ET BT /F0 1 Tf 12 0 0 12 72 274.6347 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(Recently)92(, I spent some time at a natural health farm. My blood pr)17(essur)18(e was up, my)]TJ 0 -1.2 TD [(weight was up, and I felt terrible. I fasted on juices, raw vegetables and fruit, and water)92(. I)]TJ 0 -1.19999 TD [(was able to keep my pr)18(essur)17(e at a normal level while I was ther)18(e, without medication. I)]TJ 0 -1.2 TD [(would like to r)18(etur)-18(n to the health farm for a water fast. Since I have polycystic kidneys, is)]TJ 0 -1.19999 TD [(ther)18(e any harm involved? When I r)17(etur)-18(ned in October after a 10-day stay)92(, I had a blood)]TJ 0 -1.2 TD [(pr)17(essur)18(e test, which tur)-18(ned out to be the best of all tests in the past 9 or 10 years.)]TJ ET BT /F10 1 Tf 10 0 0 10 72 177.7848 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(W)79(e are what we eat. Y)116(ou provide a good example of what the National Institutes of Health and the Hear)-18(t Lung and Blood)]TJ 0 -1.2 TD 0.0251 Tw (Institute and the National Education Program for High Blood Pressure recommend for the initial treatment of high blood)Tj (pressure: DIET AND LIFESTYLE MODIFICA)' 17.81692 0.00001 TD (TION. Regular exercise, weight loss if necessar)Tj 19.33026 0.00001 TD 0.025 Tw [(y)116(, and reduced sodium intak)19(e)]TJ -37.14718 -1.2 TD [(can help control hyper)-18(tension in the majority of individuals with mild essential hyper)-18(tension and help to control blood)]TJ T* [(pressure in others with kidney disorders. Unfor)-18(tunately)116(, most patients have a difficult time successfully modif)-18(ying their)]TJ T* [(diet enough to reduce the amount of salt in their diet to a level that will reduce blood pressure. P)24(ar)-19(t of the difficulty is)]TJ T* [(related to the fact that 80% of our dietar)-18(y salt intak)19(e comes from processing of food or preser)-18(vatives. This is something)]TJ 0.0251 Tw (that we as individuals cannot change without obtaining our foods from fresh, unprocessed sources.)' ET BT /F0 1 Tf 9 0 0 9 40.4999 36.4268 Tm /CS0 cs 1 scn 0.2778 Tc 0.0278 Tw (18 )Tj 2.8349 0 Td 0.5 scn (Q&A on PKD)Tj /F6 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj ET Q endstream endobj 31 0 obj << /Length 7204 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F10 1 Tf 10 0 0 10 36 712.9834 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(One special feature of the health far)-18(m that you describe is the use of vegetables and fr)-18(uits in the diet. These foods are)]TJ 0 -1.2 TD 0.0251 Tw (rich in potassium. Although patients with kidney disease can have a difficult time with maintaining potassium balance, if)Tj 0 -1.19999 TD 0.025 Tw [(kidney function is nor)-18(mal or near nor)-18(mal, increasing potassium intak)19(e is not a problem. Interestingly)116(, if one increases)]TJ 0 -1.2 TD [(potassium intak)19(e, par)-18(ticularly if he or she had a relatively low potassium intak)18(e to begin with, blood pressure will decrease)]TJ T* [(significantly)116(. P)23(ar)-18(t of the benefit that you received from visiting this health far)-18(m is in par)-18(t related to the increase in potas-)]TJ 0 -1.19999 TD [(sium in the diet you received. Clearly)116(, if one is about to embark on a major change in their diet, it is impor)-18(tant to review)]TJ 0 -1.2 TD [(the potential changes with your dietician or doctor)56(. One of the most impor)-18(tant advances for patients with renal disease,)]TJ T* [(with GFR below 50 ml/min, was instituted in Januar)-18(y 2002 is that any Medicare or Medicaid beneficiar)-18(y is eligible for a full)]TJ 0 -1.20001 TD [(consultation and regular follow-up with a dietician to obtain the cor)18(rect infor)-18(mation regarding dietar)-18(y intak)19(e.)]TJ 0 -2.39999 TD [(W)79(ater loading in people with nor)-18(mal renal function is usually safe, and most individuals can drink large amounts of water)]TJ 0 -1.2 TD [(without a problem. However)56(, if one has less than nor)-18(mal renal function, or if one is taking medicine(s) that affect water)]TJ 0 -1.19999 TD [(handling by the kidney)116(, such as a diuretic or water pill, increasing water intak)19(e should be done with caution. No one)]TJ 0 -1.2 TD [(should be drinking in excess of 10 liters of water a day)116(. )]TJ ET BT /F0 1 Tf 12 0 0 12 36 519.4341 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(I have PKD, am the mother of one child, and very much want another child. I r)18(ead that)]TJ 0 -1.2 TD [(mor)18(e than thr)17(ee pr)18(egnancies could have a negative ef)18(fect on a woman with PKD. Why is)]TJ 0 -1.19999 TD [(thr)18(ee the magic number? Ar)17(e two pr)18(egnancies almost as bad?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 465.784 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (Increasing number of pregnancies has been associated with a ver)Tj 26.75971 0 TD (y small negative effect on renal outcome in ADPKD. This)Tj -26.75971 -1.19999 TD (effect is so small that it is only apparent by statistical analyses \(analysis of a large number of ADPKD women, and not an)Tj 0 -1.2 TD (individual patient\) when a woman has had more than three pregnancies. There is no magical cutoff between two and)Tj T* 0.025 Tw [(three pregnancies. If you are other)-18(wise healthy and do not have medical conditions related to ADPKD such as hyper)-18(ten-)]TJ 0 -1.19999 TD -0.0149 Tc 0.0251 Tw (sion or renal insufficiency)Tj 10.39681 0 TD -0.015 Tc (, the chances of your having a successful pregnancy and not causing damage to your kidneys is)Tj -10.39681 -1.2 TD 0.025 Tw [(extremely good. Successful pregnancies occur in ADPKD women with the same rate of success as in the general popula)1(-)]TJ T* [(tion. However)56(, new-onset hyper)-18(tension, worsening hyper)18(tension and pre-eclampsia are frequent complications occur)18(ring)]TJ 0.0251 Tw (in up to 30% of pregnancies. These complications are most common in women with hyper)' 37.69264 0 TD -0.0149 Tc (tension or renal insufficiency)Tj -37.69264 -1.19999 TD -0.015 Tc 0.025 Tw [(prior to becoming pregnant. Should you become pregnant, it is impor)18(tant for you to see your obstetrician regularly and)]TJ 0 -1.2 TD 0.0251 Tw (to see a nephrologist who has experience in taking care of women with renal disease. )Tj ET BT /F0 1 Tf 12 0 0 12 36 320.2346 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(I have PKD and have been taking Enalapril for thr)18(ee years with excellent blood pr)17(essur)18(e)]TJ 0 -1.2 TD [(contr)18(ol. I r)17(ecently r)18(ead in W)18(orst Pill, Best Pills II by W)17(olfe and Hope that Enalapril)]TJ 0 -1.19999 TD -0.0001 Tc (shouldn\325)Tj 3.94531 0 TD 0.0278 Tw (t be taken by people with kidney disease. My kidney function has always tested)Tj -3.94531 -1.2 TD -0.0002 Tc (satisfactory)Tj 5.29834 0 TD -0.0001 Tc (. Should I be concer)Tj 9.69508 0 TD (ned?)Tj ET BT /F10 1 Tf 10 0 0 10 36 252.1845 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(There is reasonable concer)-18(n that individuals with advanced renal disease or ser)-18(um creatinine concentrations greater than)]TJ 0 -1.2 TD [(3.0 mg/dl should be careful when taking angiotensin-conver)-18(ting enzyme inhibitors. When renal function is this low)112(, A)18(C)1(E)]TJ T* [(inhibitors can cause an acute, reversible change in renal function par)-18(ticularly when individuals are taking diuretics simulta-)]TJ 0 -1.19999 TD [(neously or are on low protein diets. Impor)-18(tantly)116(, potassium handling by the kidney can be affected in individuals with)]TJ 0 -1.2 TD -0.0149 Tc 0.0251 Tw (poor renal function and A)Tj 10.59609 -0.00001 TD -0.015 Tc (CE inhibitors can exacerbate the poor handling of potassium. In other words, patients with poor)Tj -10.59609 -1.19999 TD 0.025 Tw [(renal function, taking A)19(CE inhibitors can develop hyperkalemia or a high potassium concentration in the blood. This is)]TJ 0 -1.19998 TD 0.0251 Tw (dangerous, and, if potassium levels are too high, it can be a lifethreatening problem. This is most lik)Tj 41.53012 0.00001 TD -0.0151 Tc (ely why this book)Tj -41.53012 -1.20001 TD -0.0149 Tc (cautions against using these agents in patients with renal disease. )Tj 0 -2.4 TD -0.02 Tc (Given that A)Tj 5.01938 0.00001 TD -0.0201 Tc (CE inhibitors appear to car)Tj 10.9038 0.00001 TD 0 Tc (r)Tj 0.36151 0.00001 TD -0.02 Tc (y many beneficial effects in patients with renal disease, we tr)Tj 24.43582 0.00001 TD -0.0201 Tc (y our best to be able to)Tj -40.72051 -1.20002 TD -0.02 Tc (use them even in patients with mark)Tj 14.85875 0.00001 TD (edly elevated creatinine levels. There are many ways to continue A)Tj 26.90926 0.00001 TD -0.0201 Tc (CE inhibitor therapy)Tj -41.76801 -1.20001 TD -0.02 Tc 0.025 Tw [(in these situations and avoid high potassium levels. This includes modification of the diet to reduce potassium intak)19(e, the)]TJ 0.0251 Tw (addition of diuretics to help the kidneys excrete potassium, the use of a potassium-binding called Kayexalate, and to main)' 49.41888 0.00001 TD 0 Tc (-)Tj -49.4189 -1.2 TD -0.02 Tc (tain volume status or fluid intak)Tj 12.83769 0.00001 TD -0.0199 Tc (e to avoid dehydration and fur)Tj 12.40038 0.00001 TD -0.02 Tc (ther elevations in ser)Tj 8.48694 0.00001 TD (um creatinine concentration.)Tj ET BT /F0 1 Tf 9 0 0 9 461.1341 36.4268 Tm /CS0 cs 0.5 scn 0.2778 Tc 0.0278 Tw (Q&A on PKD)Tj 9.8731 0 Td 1 scn (19)Tj /F7 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj ET Q endstream endobj 32 0 obj << /Length 5635 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 12 0 0 12 72 711.4336 Tm /CS0 cs 1 scn 0.028 Tw [(My blood pr)18(essur)17(e is 145/100, and my doctor has r)18(ecommended Enalapril, which may)]TJ 0 -1.2 TD [(help pr)18(eserve kidney function as well as lower blood pr)17(essur)18(e, as I understand it. )]TJ ET BT /F10 1 Tf 10 0 0 10 72 672.1835 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(It is ver)-18(y impor)-18(tant to bring blood pressure under good control, as this will diminish scar)-18(ring of the tiny blood vessels in)]TJ 0 -1.2 TD [(the kidney)116(. Enalapril has been used for blood pressure control in polycystic patients with reasonable success. It is usually)]TJ 0 -1.19999 TD 0.0251 Tw (prescribed together with a salt-restricted diet and weight control.)Tj 0 -2.4 TD 0.025 Tw [(W)79(e do not know for sure if Enalapril or other related dr)-18(ugs that block the angiotensin-conver)-18(ting enzyme have any other)]TJ 0 -1.19999 TD 0.0251 Tw (special actions for polycystic kidneys, but one hypothesis suggests that, by lowering the blood pressure in the kidney)Tj 0 -1.2 TD 0.025 Tw [(filters \(called glomer)-18(uli\), we may prevent additional scar)18(ring of these impor)-18(tant str)-18(uctures. )]TJ 0 -2.39999 TD [(Confir)-18(mation of the hypotheses will not be known for several years, but, in the meantime, Enalapril and other equally)]TJ 0 -1.20001 TD [(good blood pressure-lowering dr)-18(ugs mak)19(e good sense in the management of high blood pressure. )]TJ ET BT /F0 1 Tf 12 0 0 12 72 526.6341 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(I have ADPKD and was found to have hypertension in 1979. I have been tr)18(eated with a)]TJ 0 -1.2 TD [(combination of metopr)18(olol and hydr)17(ochlor)18(othiazide, which has kept my blood pr)18(essur)17(e)]TJ T* [(stable at 120/90. I have never r)18(ealized side ef)17(fects. My lab values ar)18(e completely normal.)]TJ 0 -1.19999 TD (I would like to know whether an ACE inhibitor (Enalapril, Captopril) would have any advan-)Tj 0 -1.2 TD [(tages in r)18(elation to my pr)17(esent pharmacologic tr)18(eatment in this stage of my hypertension. )]TJ ET BT /F10 1 Tf 10 0 0 10 72 444.1841 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Hyper)-18(tension can accelerate the progression of renal insufficiency in patients with polycystic kidney disease. There is)]TJ 0 -1.2 TD [(reason to think that A)19(CE inhibitors may have a theoretical advantage in the treatment of hyper)-18(tension inpatients with)]TJ 0.0251 Tw (ADPKD. A controlled clinical study has not been done, however)' 26.43073 0 TD (, and we would not be inclined to recommend a change)Tj -26.43073 -1.19999 TD 0.025 Tw [(in treatment if the blood pressure is well controlled with the cur)18(rent regimen. On the other hand, in patients with hyper-)]TJ 0 -1.2 TD 0.0251 Tw (tension who have not been previously treated, A)Tj 19.92833 0 TD (CE inhibitors are probably good choices for the initiation of)Tj -19.92833 -1.2 TD 0.025 Tw [(antihyper)-18(tensive therapy)116(.)]TJ ET BT /F0 1 Tf 18 0 0 18 72 330.3514 Tm /CS0 cs 0.5 scn -0.0001 Tc 0.0278 Tw (Renal Manifestations)Tj 12 0 0 12 72 301.0346 Tm 1 scn 0 Tc 0.028 Tw [(In December 1996, my polycystic 64-year)55(-old husband, who is a peritoneal dialysis)]TJ 0 -1.19999 TD [(patient, had a fever and chills. Blood cultur)18(es showed an E. coli infection. The sear)17(ch)]TJ 0 -1.2 TD [(was made for the infection site. All tests and scans of abdomen and gallbladder)92(, and)]TJ 0 -1.19999 TD -0.0002 Tc 0.0278 Tw (colonoscopy wer)Tj 7.91963 0 TD -0.0001 Tc (e negative. A urine specimen was unattainable because my husband no)Tj -7.91963 -1.2 TD 0 Tc 0.028 Tw [(longer makes urine. He had one kidney r)18(emoved four years ago due to discomfort and)]TJ -0.0001 Tc 0.0278 Tw (size. It is believed that E. coli came fr)' 17.62482 0 TD -0.0002 Tc (om the r)Tj 3.87052 0 TD -0.0001 Tc (emaining kidney)Tj 7.45552 0 TD (. I would like to know if this)Tj -28.95085 -1.20001 TD (happens with PKD patients, or is this very unusual? )Tj ET BT /F10 1 Tf 10 0 0 10 72 189.7847 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(This is not unusual. Escheri Ca Coli is a bacterium that typically comes from the gastrointestinal tract. It can mak)19(e its way)]TJ 0 -1.19999 TD [(into the urinar)-18(y system by fecal contamination or is due to the presence of stones, decreases in urinar)-18(y flow or because)]TJ 0 -1.2 TD [(the prostate glands in men get large. In a patient with polycystic kidney disease, an infection lik)19(e this could easily come)]TJ 0.0251 Tw (from a polycystic liver)' 8.8914 0.00001 TD -0.0151 Tc (, the gallbladder)Tj 6.56729 0.00001 TD -0.015 Tc 0.025 Tw [(, from diver)-18(ticular disease that is of)-18(ten found in PKD patients, or from the urinar)-18(y)]TJ -15.45869 -1.2 TD [(system (from the bladder up to the kidney). It is possible that it has come from his polycystic kidney; however)56(, this)]TJ T* [(should be considered as a diagnosis of exclusion until all other possible sites have been r)-18(uled out. Given that this is the)]TJ 0.0251 Tw (first time that this infection has been present, it was appropriate that other tests that should be done before assuming that)' T* 0.025 Tw [(this has come from the patient\325s kidney)116(. )]TJ ET /GS0 gs 1 w /CS0 CS 1 SCN 72 324 m 576 324 l S /GS2 gs BT /F0 1 Tf 9 0 0 9 40.4999 36.4268 Tm /CS0 cs 1 scn 0.2778 Tc 0.0278 Tw (20 )Tj 2.8349 0 Td 0.5 scn (Q&A on PKD)Tj /F6 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj ET Q endstream endobj 33 0 obj << /Length 7077 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 12 0 0 12 36 711.4336 Tm /CS0 cs 1 scn 0.028 Tw [(Can one have a kidney infection with a negative urinalysis and urine cultur)18(e?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 686.5835 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (In patients without ADPKD, the urinalysis and the urine culture usually demonstrate evidence for infection when)Tj 0 -1.2 TD 0.025 Tw [(someone has a kidney infection. In ADPKD, the source of the infection is most of)-18(ten the cysts in the kidney that no)]TJ 0.0251 Tw (longer communicate with the collecting system or the urinar)' 24.98969 0.00001 TD (y tract. When these become infected, there is no place for)Tj -24.98969 -1.2 TD 0.025 Tw [(the bacteria to travel to in the urinar)-18(y system, so it is infrequent that the urine culture is positive in patients with ADPKD)]TJ T* [(who have a cyst infection. It is more lik)19(ely that the bloodstream will have a positive culture than will the urine. Even so, it)]TJ T* [(is impor)-18(tant to obtain a urine sample and test it for the presence of bacteria. If the bacteria is identified, it is most lik)19(ely)]TJ 0 -1.19999 TD [(that the cor)-18(rect antibiotic will be chosen for the treatment of infection. )]TJ ET BT /F0 1 Tf 12 0 0 12 36 577.0339 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(Is aspiration of a single large cyst indicated for r)18(elief of r)17(ecurr)18(ent urinary infection?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 552.1838 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(There are multiple types of cysts that are not par)-18(t of the genetic disease, polycystic kidney disease. Of)-18(tentimes, cysts can)]TJ 0 -1.2 TD [(be causing obstr)-18(uction in the urinar)-18(y tract, which predisposes to infection, or)56(, alter)-19(natively)117(, infections may have nothing to)]TJ 0 -1.19999 TD [(do with the cysts at all since solitar)-18(y cysts are common in the general population. A physician should evaluate each case)]TJ 0 -1.2 TD 0.0251 Tw (so as to decide whether autosomal dominant polycystic kidney disease is present. In ADPKD, aspiration of single cysts is)Tj T* 0.025 Tw [(not routinely recommended unless severe pain or refractor)-18(y infection is present. If another kind of cystic disease is)]TJ 0 -1.19999 TD [(present, the physician will need to deter)-18(mine what relationship that cyst has to recur)-18(rent urinar)-18(y tract infections. If a)]TJ 0 -1.2 TD -0.0149 Tc 0.0251 Tw (single cyst is causing obstr)Tj 10.81432 0 TD -0.015 Tc (uction, it can be aspirated under ultrasound guidance, and relief of pain symptoms may be)Tj -10.81432 -1.2 TD (obtained. )Tj ET BT /F0 1 Tf 12 0 0 12 36 430.6343 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(Antibiotics help r)18(ecurr)17(ent kidney infections for a few days, but the symptoms \320 nausea,)]TJ 0 -1.2 TD [(fever)92(, chills, pain, fatigue and weakness \320 r)17(ecur when they ar)18(e discontinued. My doctor is)]TJ 0 -1.19999 TD -0.0002 Tc 0.0278 Tw (open to suggestions. )Tj ET BT /F10 1 Tf 10 0 0 10 36 376.9843 Tm 0 0 0 1 k -0.015 Tc (Recur)Tj 2.39733 0 TD 0.025 Tw [(rent kidney infections usually mean that one or more cysts have been infected. It is impor)-18(tant for the physician to)]TJ -2.39733 -1.2 TD [(t)-1(r)-19(y to culture the bacteria from the bloodstream and the urine so that a specific treatment can be prescribed.)]TJ -0.0148 Tc (Unfor)' 2.39391 0 TD -0.0149 Tc (tunately)Tj 3.17953 0 TD -0.015 Tc 0.0251 Tw (, the bacteria \322hide out\323 in the cysts and cannot be cultured in many cases, and antibiotics must be given)Tj -5.57344 -1.20001 TD 0.025 Tw [(blindly)116(. W)79(e have known several patients who required continuous antibiotic treatment for several years in order to)]TJ 0 -1.19999 TD 0.0251 Tw (control the symptoms. )Tj 0 -2.4 TD (Research suppor)Tj 6.91167 0 TD 0.025 Tw [(ted by the PKD F)42(oundation has led to the discover)-18(y of two dr)18(ugs that may be helpful in some patients)]TJ -6.91167 -1.19999 TD 0.0251 Tw (with recur)Tj 4.23627 0.00001 TD (rent and resistant kidney cyst infections. One of them, chloramphenicol, is an old-time medicine that works)Tj -4.23627 -1.20001 TD (well but has a reputation for causing serious anemia on rare occasions. Never)Tj 32.04111 0.00001 TD (theless, it can be used for treating difficult)Tj -32.04111 -1.20001 TD 0.025 Tw [(cyst infections if patients are willing to tak)19(e the small risk. Gyrase inhibitors \(nor)-18(foxacin and ciprofloxacin\) are ver)-18(y good)]TJ 0 -1.19999 TD [(for treating infected cysts. Considerable experience has been gained with these dr)-18(ugs, and, so far)56(, only a few problems)]TJ 0 -1.2 TD [(have sur)-18(faced. )]TJ ET BT /F0 1 Tf 12 0 0 12 36 207.4348 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(I am a 26-year)55(-old female who has had thr)17(ee urinary tract infections in the last two)]TJ 0 -1.2 TD -0.0001 Tc 0.0278 Tw (months. My back has r)Tj 10.91798 0 TD (eally been bothering me. )Tj ET BT /F10 1 Tf 10 0 0 10 36 168.1848 Tm 0 0 0 1 k -0.015 Tc (Recur)Tj 2.39733 0.00001 TD -0.0148 Tc 0.0251 Tw (rent urinar)Tj 4.43214 0.00001 TD -0.015 Tc (y tract infection is a ver)Tj 9.53019 0.00001 TD (y common problem for women, and especially difficult for PKD patients. Most)Tj -16.35966 -1.20002 TD 0.025 Tw [(of)-18(ten the bacteria \(ger)-18(ms\) that cause these infections enter the urinar)-18(y tract through the urethra, the opening to the)]TJ 0 -1.2 TD 0.0251 Tw (bladder just below the pelvic bone. Many women can relate the infections to recent sexual intercourse. F)Tj 43.5673 0.00001 TD -0.0149 Tc (or patients with)Tj -43.5673 -1.2 TD -0.015 Tc (PKD, it is ver)Tj 5.29969 0.00001 TD -0.0149 Tc (y impor)Tj 3.22189 0.00001 TD -0.015 Tc (tant that a urine culture be obtained each time you have symptoms of infection \(bur)Tj 34.70304 0.00001 TD -0.0148 Tc (ning on urina)Tj 5.55358 0.00001 TD 0 Tc (-)Tj -48.7782 -1.20002 TD -0.015 Tc 0.025 Tw [(tion, a feeling of urgency to pass urine, fever)56(, chills, and back pain that develops with these other symptoms\). Y)116(our doctor)]TJ 0.0251 Tw (should do the culture before you receive antibiotic treatment. V)' 26.43705 0.00001 TD -0.0148 Tc (er)Tj 0.85244 0.00001 TD -0.0149 Tc (y of)Tj 1.5266 0.00001 TD -0.015 Tc (ten the infecting bacteria can be identified and)Tj -28.8161 -1.2 TD (specific treatment prescribed. The ger)Tj 15.92932 0.00001 TD (m may be different with each infection, suggesting that the bacteria are invading)Tj -15.9293 -1.2 TD 0.025 Tw [(from outside the body)116(. If the same ger)-18(m is found each time, it is possible that the antibiotics are not destroying a stub)1(-)]TJ -0.0151 Tc (bor)' 1.438 0 TD -0.015 Tc [(n focus of infection in the urinar)-18(y tract. )]TJ ET BT /F0 1 Tf 9 0 0 9 461.1341 36.4268 Tm /CS0 cs 0.5 scn 0.2778 Tc 0.0278 Tw (Q&A on PKD)Tj 9.8731 0 Td 1 scn (21)Tj /F6 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj ET Q endstream endobj 34 0 obj << /Length 6029 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F10 1 Tf 10 0 0 10 72 712.9834 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Recur)-18(rent infection with the same ger)-18(m can be seen in patients with infected cysts or kidney stones. All urinar)-18(y tract)]TJ 0 -1.2 TD -0.0149 Tc 0.0251 Tw (infections in PKD patients should be treated aggressively and usually for longer periods than in persons with nor)Tj 46.28415 0.00001 TD -0.0155 Tc (mal)Tj -46.28415 -1.19999 TD -0.015 Tc 0.025 Tw [(kidneys. W)79(omen patients with recur)-18(rent infections \(who have reasonably nor)-18(mal kidney function\) are advised to drink six)]TJ 0 -1.2 TD [(to eight cups of fluid ever)-18(y day (preferably plain water), urinate ever)-18(y two hours during the day and within 30 minutes)]TJ T* [(af)-18(ter intercourse. Evaluation by a nephrologist or urologist is also advisable. )]TJ ET BT /F0 1 Tf 12 0 0 12 72 627.4338 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(Can persons with PKD have kidney stones r)18(emoved with the new shockwave machines?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 602.5837 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (PKD patients have a high incidence of kidney stones, and these can cause serious problems. A recent review of the use,)Tj 0 -1.2 TD (in a number of medical centers, of extra corporeal shock-wave lithotripsy on PKD patients with stones suggests that it can)Tj (be used with few complications. )' ET BT /F0 1 Tf 12 0 0 12 72 541.034 Tm /CS0 cs 1 scn -0.011 Tc 0.028 Tw [(I am male, 38 years old, and was diagnosed with PKD in 1987. I have r)18(ecurr)18(ent calcium)]TJ 0 -1.19999 TD [(oxalate stones for which I take hydr)18(ochlor)17(othiazide twice daily)92(, potassium citrate \(12 tablets)]TJ 0 -1.2 TD [(daily\) and magnesium oxide. I pass thr)18(ee to five stones per week, all less than 3mm in)]TJ T* [(diameter)92(. I have normal amounts of oxalate in my urine and drink thr)18(ee to four quarts of)]TJ 0 -1.19999 TD [(water a day)92(. Nothing seems to work. Will anything stop kidney stone formation? )]TJ ET BT /F10 1 Tf 10 0 0 10 72 458.584 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Stone for)-18(mation can be stopped in most patients, including those with PKD, with simple measures such as drinking)]TJ 0 -1.19999 TD [(enough fluid and, when the chemical composition of the urine is abnor)18(mal, with dietar)-18(y changes or medications such as)]TJ 0 -1.2 TD 0.0251 Tw (those you are taking. Y)Tj 9.5696 0 TD (ou should realize that passage of stones does not always indicate that a par)Tj 30.80757 0 TD -0.0149 Tc (ticular treatment is not)Tj -40.37717 -1.20001 TD -0.015 Tc (working. X)Tj 4.65035 0 TD (-rays are needed to confir)Tj 10.53171 0 TD 0.025 Tw [(m that the stones that are passed are new and not stones for)-18(med before star)-18(ting the)]TJ -15.18206 -1.2 TD 0.0251 Tw (treatment. The patients who fail the conventional types of treatment and continue to for)Tj 36.64757 0 TD (m stones may benefit from evalu)Tj 13.45462 0 TD 0 Tc (-)Tj -50.1022 -1.20001 TD -0.015 Tc (ation in centers specializing in renal stone disease.)Tj ET BT /F0 1 Tf 12 0 0 12 72 361.0345 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (I have been told that my kidneys measur)Tj 18.8444 0 TD (e 38 and 28 centimeters in length. What is the)Tj -18.8444 -1.2 TD 0 Tc 0.028 Tw [(r)18(ecor)18(d kidney size in PKD?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 321.7844 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (There is no Ripley)Tj 7.48211 0 TD (\325s Believe it or Not for kidney size in PKD. However)Tj 21.35923 0 TD (, 38 and 28 cm are large for a polycystic kidney)Tj 19.09698 0 TD 0 Tc (.)Tj -47.93832 -1.20001 TD -0.015 Tc (Most end stage PKD kidneys weigh approximately 20-25 lbs or 10 kg each. This accounts for the pain, fatigue and)Tj 0 -1.19999 TD 0.025 Tw [(decreased energy)116(, difficulty with spor)-18(ts and an active lifestyle that many PKD patients feel. As well, when kidneys get to be)]TJ 0 -1.2 TD 0.0251 Tw (this size, eating regular quantities of food can be difficult.)Tj ET BT /F0 1 Tf 12 0 0 12 72 248.2348 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(I have polycystic kidney disease and have been tr)18(eated for hypertension for a number of)]TJ 0 -1.2 TD -0.0001 Tc 0.0278 Tw (years. At the last visit with my nephr)Tj 16.8444 0 TD (ologist, I was informed that my urine contains pr)Tj 22.44664 0 TD -0.0002 Tc (otein.)Tj -39.29104 -1.20001 TD 0 Tc 0.028 Tw [(Is this abnormal, and is this cause for concer)-18(n? )]TJ ET BT /F10 1 Tf 10 0 0 10 72 194.5847 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (Protein in the urine is not a common manifestation of ADPKD. Less than 20% of all ADPKD patients have detectable levels)Tj 0 -1.19999 TD 0.025 Tw [(of proteinuria by urinar)-18(y dipstick. There are many renal diseases that have large amounts of proteinuria associated with)]TJ 0 -1.2 TD 0.0251 Tw (them, and this is not one of those conditions. The proteinuria that is found in ADPKD is low grade and usually less than)Tj T* 0.025 Tw [(one gram/day)116(. If there is more protein in the urine than that, it is possible that another process is taking place in your)]TJ 0.0251 Tw (kidneys. When found in ADPKD, proteinuria is usually associated with more severe disease including higher blood pres)' 49.30324 0.00001 TD 0 Tc (-)Tj -49.30324 -1.19999 TD -0.015 Tc 0.025 Tw [(sure levels, bigger kidneys, higher ser)-18(um creatinine concentrations or lower levels of renal function. This means that)]TJ 0 -1.2 TD [(proteinuria in ADPKD is probably a mark)19(er for worse renal function and may also predict those individuals who are more)]TJ -0.0155 Tc (lik)' 0.9543 0 TD -0.0149 Tc 0.0251 Tw (ely to progress to ESRD.)Tj ET BT /F0 1 Tf 9 0 0 9 40.4999 36.4268 Tm /CS0 cs 1 scn 0.2778 Tc 0.0278 Tw (22 )Tj 2.8349 0 Td 0.5 scn (Q&A on PKD)Tj /F7 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj /F7 1 Tf 0.27802 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj /F7 1 Tf 0.27802 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj ET Q endstream endobj 35 0 obj << /Length 5654 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 12 0 0 12 36 711.4336 Tm /CS0 cs 1 scn 0.028 Tw [(My wife has PKD and would like to know why she has so much r)18(enal bleeding. What)]TJ 0 -1.2 TD [(causes it, and what, if anything, can be done to contr)18(ol it?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 672.1835 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Renal bleeding can be due to a number of causes. Bleeding can be spontaneous from a r)-18(uptured cyst. This can be painful)]TJ 0 -1.2 TD 0.0251 Tw (or painless, depending on where the cyst lies and how much stretch to the cyst occurs. The cause of bleeding from a)Tj 0 -1.19999 TD 0 Tc (r)Tj 0.36653 0.00001 TD -0.015 Tc 0.025 Tw [(uptured cyst is not always clear)56(, but recent trauma can be impor)18(tant; use of anti-platelet dr)-18(ugs such as adult aspirin or)]TJ -0.36653 -1.20001 TD [(Coumadin can be impor)-18(tant. The larger the kidney or cyst, the greater the chance that bleeding will occur)56(. Therefore,)]TJ 0.0251 Tw (those individuals with bigger kidneys are at increased risk for bleeding from their kidneys. )' 0 -2.39999 TD 0.025 Tw [(Bleeding can also come from a stone in the kidney or collecting system of an ADPKD kidney)116(. Infection, from either the)]TJ 0 -1.2 TD [(bladder or kidney)116(, can also be a source of blood in the urine. Given that some of these conditions need early medical)]TJ 0 -1.19999 TD [(treatment, whenever bleeding occurs, it is impor)-18(tant to see your physician right away or at least contact her/his office.)]TJ 0 -1.20001 TD [(The bleeding, if due to a hemor)-18(rhagic cyst, should be limited to as shor)-18(t a time period as possible. The way to help this)]TJ T* [(happen is to drink plenty of fluids, k)19(eep your blood pressure controlled, and, if bleeding does not disappear in 24-48)]TJ 0 -1.2 TD 0.0251 Tw (hours, to go to bed or the recumbent position. All of these maneuvers should help to limit the duration of bleeding from)Tj 0 -1.19999 TD 0.025 Tw [(the kidney)116(.)]TJ ET BT /F0 1 Tf 18 0 0 18 36 474.351 Tm /CS0 cs 0.5 scn -0.0002 Tc (Pr)Tj 1.00098 0 TD -0.0001 Tc (egnancy)Tj 3.83545 0 TD 0 Tc 0.028 Tw [(, Birth Contr)18(ol, and Menopause)]TJ 12 0 0 12 36 445.0343 Tm 1 scn -0.0001 Tc 0.0278 Tw (I\325m 18 years old \320 diagnosed with PKD at birth. My cr)Tj 25.07707 0 TD (eatinine level is 3.3. How might I go)Tj -25.07707 -1.2 TD 0 Tc 0.028 Tw [(about having childr)18(en without a complicated pr)17(egnancy?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 405.7842 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Assuming you are of nor)-18(mal adult height and weight, the creatinine level suggests that kidney function is between one-)]TJ 0 -1.2 TD [(four)-18(th and one-third of nor)-18(mal. If high blood pressure is present, both of the factors of a low kidney filtration rate and)]TJ 0.0251 Tw (high blood pressure mak)' 10.30449 0 TD 0.025 Tw (e pregnancy complicated and sometimes extremely difficult. Not only may there be complica-)Tj -10.30449 -1.19999 TD [(tions that endanger health, but there may be complications that endanger the baby)-36(\325s health. Prior to pregnancy)116(, it is ver)18(y)]TJ 0 -1.2 TD [(impor)-18(tant to seek the advice and counsel of a \322high risk\323 obstetrician\321that is, someone who tak)19(es care of pregnant)]TJ -0.0151 Tc 0.0251 Tw (women who have complicated health problems. One should ask specific questions about the risks to the mother and to)' 0 -1.19999 TD -0.0153 Tc (the baby)Tj 3.41825 0 TD -0.015 Tc (. In autosomal dominant PKD, the child will have one out of two chances of having the disease; if the disease is)Tj -3.41825 -1.2 TD (autosomal recessive, the disease will not be passed on unless the father should have one recessive gene. A)Tj 43.99413 0 TD (t the moment,)Tj -43.99413 -1.2 TD (there is no way to know about this in advance.)Tj ET BT /F0 1 Tf 12 0 0 12 36 272.2346 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(I had a large ovarian cyst and one ovary r)18(emoved when I was 21 years old. My gynecolo)-1(-)]TJ 0 -1.19999 TD -0.0002 Tc 0.0278 Tw (gist has r)Tj 4.2792 0 TD -0.0001 Tc (ecommended staying on low-dose birth contr)Tj 21.15919 0 TD (ol pills until I am r)Tj 8.21461 0 TD -0.0002 Tc (eady to have)Tj -33.653 -1.20001 TD 0 Tc 0.028 Tw [(childr)18(en to pr)17(event the formation of mor)18(e ovarian cysts. I have been taking these pills for)]TJ 0 -1.2 TD -0.0002 Tc 0.0278 Tw (seven years, and my blood pr)Tj 13.75294 0 TD (essur)Tj 2.50146 0 TD -0.0001 Tc (e and kidney function ar)Tj 11.20563 0 TD (e normal. Could birth contr)Tj 12.78736 0 TD -0.0003 Tc (ol)Tj -40.24739 -1.20001 TD 0 Tc 0.028 Tw [(pills speed up the gr)18(owth of my kidney cysts?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 189.7847 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(There is no infor)-18(mation to show that bir)-18(th control pills increase the growth of kidney cysts. Computed tomographic)]TJ 0 -1.19999 TD [(studies have shown that hor)-18(mone replacement therapy has no effect on renal volume or renal cyst volume in a small)]TJ 0 -1.2 TD [(group of APDKD women. The relationship between bir)-18(th control pill use and progression of cystic disease is strongest in)]TJ 0.0251 Tw (cystic disease of the liver as opposed to cystic disease of the kidney)' 27.5235 0.00001 TD -0.0151 Tc (. )Tj ET /GS0 gs 1 w /CS0 CS 1 SCN 36 468 m 540 468 l S /GS2 gs BT /F0 1 Tf 9 0 0 9 461.1341 36.4268 Tm /CS0 cs 0.5 scn 0.2778 Tc 0.0278 Tw (Q&A on PKD)Tj 9.8731 0 Td 1 scn (23)Tj /F6 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj ET Q endstream endobj 36 0 obj << /Length 6175 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 12 0 0 12 72 711.4336 Tm /CS0 cs 1 scn 0.028 Tw [(Is estr)18(ogen r)17(eplacement therapy after menopause contraindicated in patients with)]TJ 0 -1.2 TD -0.0001 Tc (ADPKD?)Tj ET BT /F10 1 Tf 10 0 0 10 72 672.1835 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Even though it has been shown that hor)-18(mone replacement therapy affects the rate of growth of liver cysts in ADPKD,)]TJ 0 -1.2 TD [(cysts in the liver do not appear to affect liver function. Even in individuals with massive polycystic liver disease, liver)38(-func-)]TJ 0 -1.19999 TD -0.0149 Tc 0.0251 Tw (tion tests remain nor)Tj 8.62099 0.00001 TD -0.015 Tc (mal, and liver mass unaffected by cystic disease remains unchanged. So, if there is good indication to)Tj -8.62099 -1.20001 TD (receive estrogen replacement therapy and the liver cystic disease is mild, it is reasonable to consider the estrogen patch)Tj 0 -1.2 TD 0.025 Tw [(for hor)-18(mone replacement therapy)116(. )]TJ ET BT /F0 1 Tf 12 0 0 12 72 586.6339 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(I saw my gynecologist because of irr)18(egular menstrual cycles and was diagnosed with)]TJ 0 -1.19999 TD [(polycystic ovary syndr)18(ome. Is this r)17(elated to polycystic kidney disease? Ar)18(e patients with)]TJ 0 -1.2 TD [(PKD mor)18(e likely to have polycystic ovaries?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 532.9839 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(P)42(olycystic ovaries are a separate clinical entity associated with facial hair)56(, acne, and infer)-18(tility)116(. This for)-18(m of polycystic)]TJ 0 -1.2 TD [(ovaries is not associated with ADPKD. However)56(, in women with ADPKD, cysts in the ovaries can develop. They are not)]TJ 0 -1.20001 TD [(related to polycystic ovar)-18(y syndrome. The treatment of polycystic ovaries unrelated to ADPKD usually includes the use of)]TJ 0 -1.19999 TD [(bir)-18(th control pills. As well, the polycystic ovaries can be treated by taking a small piece of tissue out of the polycystic ovar)18(y)116(.)]TJ 0 -1.2 TD [(If bir)-18(th control pills are used, it is wise to undergo imaging of the liver to deter)-18(mine if significant polycystic liver disease is)]TJ T* [(present. If so, one might consider wedge resection of the polycystic ovar)-18(y instead of bir)-18(th control pill use. Cur)-18(rently)116(, poly-)]TJ T* [(cystic ovaries in PKD have no known associated abnor)-18(malities and are not treated unless large enough to cause pain. If)]TJ 0 -1.19999 TD [(this occurs, removal of the ovar)-18(y is of)-18(ten considered. )]TJ ET BT /F0 1 Tf 18 0 0 18 72 395.1512 Tm /CS0 cs 0.5 scn 0 Tc 0.028 Tw [(Kidney Failur)18(e, Dialysis, T)91(ransplantation)]TJ 12 0 0 12 72 365.8345 Tm 1 scn -0.0001 Tc 0.0278 Tw (I am contemplating a kidney transplant after being on CAPD for a year)Tj 32.57781 0 TD (. Since we now)Tj -32.57781 -1.2 TD (know that PKD is genetically transmitted, I am wondering whether ther)Tj 32.77882 0 TD (e is a genetic)Tj -32.77882 -1.2 TD 0 Tc 0.028 Tw [(tendency for r)18(ejection of cadaver organs. My father had thr)17(ee kidney transplants, and all)]TJ T* [(failed. Does that mean that I have a genetic pr)18(edisposition to experience a r)17(ejection?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 297.7845 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(There are risk factors for the loss of a transplanted kidney)116(. T)135(ransplanted kidneys will reject if immunosuppressive regi-)]TJ 0 -1.2 TD 0.0251 Tw (mens are not properly administered. They will also reject if the match between the donor and the recipient is not good.)Tj -0.0149 Tc (Impor)' 2.59045 0.00001 TD -0.015 Tc (tantly some antigens are more rejectable than others, and, some people, unfor)Tj 32.33434 0.00001 TD -0.0149 Tc (tunately)Tj 3.17953 0.00001 TD -0.015 Tc (, can inherit these. However)Tj 11.79896 0.00001 TD 0 Tc (,)Tj -49.90328 -1.20001 TD -0.015 Tc 0.025 Tw [(the role of these inherited antigens becomes quite small when appropriate immunosuppression is given. The immuno)1(-)]TJ 0 -1.2 TD 0.0251 Tw (suppressive medication\325s available today are more effective than medication used only 5-10 years ago. Regardless of)Tj (someone\325s genetic mak)' 9.69306 0.00001 TD (eup, as the number of transplants in an individual increases, the chance of rejection increase)Tj -9.69306 -1.20001 TD 0 Tw [(mark)18(edly)116(.)]TJ ET BT /F0 1 Tf 12 0 0 12 72 188.2349 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(What is the normal serum cr)18(eatinine in adults, and how do you interpr)17(et it?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 163.3848 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Ser)-18(um creatinine is a mark)19(er of kidney function or glomer)18(ular filtration rate that all doctors and health care providers use.)]TJ 0 -1.2 TD 0.0251 Tw (It has many advantages and is easy to measure. However)Tj 23.51446 0.00001 TD (, there is a wide range of \322nor)Tj 12.21576 0.00001 TD 0.025 Tw [(mal\323 for ser)-18(um creatinine that can)]TJ -35.73022 -1.20001 TD 0.0251 Tw (depend on the race of the patient, the body weight or muscle mass, the gender and the age. All of these factors mean)Tj 0 -1.2 TD 0.025 Tw [(that a ser)-18(um creatinine concentration of 1.0 mg/dl \(considered nor)-18(mal\) in a six-foot-two inch man who works out in the)]TJ T* [(gymnasium gives a higher level of function than a ser)-18(um creatinine of 1.0 mg/dl in an elderly woman who is five foot two)]TJ 0.0251 Tw (inches. The National Institutes of Health is tr)' 18.64711 0.00001 TD (ying to help laboratories incorporate most of these variables into a for)Tj 28.75025 0.00001 TD -0.0152 Tc (mula)Tj -47.3974 -1.2 TD -0.015 Tc 0.025 Tw [(so that doctors and their patients can get an estimate of kidney function from their ser)-18(um creatinine. )]TJ ET /GS0 gs 1 w /CS0 CS 1 SCN 72 388.778 m 576 388.778 l S /GS2 gs BT /F0 1 Tf 9 0 0 9 40.4999 36.4268 Tm /CS0 cs 1 scn 0.2778 Tc 0.0278 Tw (24 )Tj 2.8349 0 Td 0.5 scn (Q&A on PKD)Tj /F6 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj ET Q endstream endobj 37 0 obj << /Length 6831 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F10 1 Tf 10 0 0 10 36 712.9834 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(F)42(or people with kidney disease of any type, it is impor)-18(tant to note that a large amount of kidney function is lost while the)]TJ 0 -1.2 TD -0.0147 Tc (ser)Tj 1.23776 0.00001 TD -0.015 Tc [(um creatinine concentration is within the nor)-18(mal range. What this means is that if an individual usually has a ser)-18(um)]TJ -1.23776 -1.19999 TD [(creatinine concentration of 0.8 mg/dl \(considered nor)-18(mal\), which stays the same for many years, and then, all of a sudden,)]TJ 0 -1.2 TD [(the ser)-18(um creatinine concentration is 1.2 mg/dl \(still considered nor)-18(mal\), that person has lost 50% of their kidney func-)]TJ T* [(tion. This is why it is so impor)-18(tant to know what your ser)-18(um creatinine is, not just that it is nor)-18(mal. )]TJ ET BT /F0 1 Tf 12 0 0 12 36 627.4338 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(I have PKD and have lost some r)18(enal function. At what hematocrit level do most people)]TJ 0 -1.2 TD [(start taking erythr)18(opoietin?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 588.1837 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(The kidney mak)19(es a hor)-19(mone called er)-18(ythropoietin. This hor)-18(mone stimulates the bone mar)-18(row to produce red cells.)]TJ 0 -1.19999 TD [(Er)-18(ythropoietin levels are increased when red cell number declines (anemia) to help maintain an appropriate red cell)]TJ 0 -1.20001 TD [(number)56(. Er)-18(ythropoietin levels decrease as kidney tissue is damaged or destroyed and usually results in anemia due to)]TJ T* [(renal disease. It was once thought that ADPKD patients did not have anemia or suffer from a loss of er)-18(ythropoietin as)]TJ 0 -1.2 TD [(much as patients with other renal diseases. W)79(e now know that this is not tr)-18(ue and that ADPKD patients are just as lik)19(ely)]TJ 0 -1.19999 TD [(as any other patient to have anemia related to renal disease. Er)18(ythropoietin is a protein and cannot be tak)19(en as a pill.)]TJ 0 -1.2 TD [(Er)-18(ythropoietin therapy should be star)-18(ted when the hematocrit is below 30% or when the patient is symptomatic.)]TJ 0 -1.20001 TD [(Er)-18(ythropoietin will only be effective if all other causes of anemia or a low blood count such as iron deficiency are)]TJ 0 -1.19999 TD [(cor)-18(rected. Given that er)-19(ythropoietin is a protein, it must be given as an injection under the skin or through the vein.)]TJ 0 -1.2 TD 0.0251 Tw (These injections are usually given once a week. )Tj ET BT /F0 1 Tf 12 0 0 12 36 442.6343 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (I am 62 years old, and I have polycystic kidney disease. My physician has told me that my)Tj 0 -1.2 TD 0 Tc 0.028 Tw [(r)18(enal function is beginning to decline, but that it may still be a few years befor)18(e I need)]TJ 0 -1.19999 TD [(dialysis. Is ther)18(e an age limit for r)17(enal transplantation?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 388.9842 Tm 0 0 0 1 k -0.0149 Tc 0.0251 Tw (In the United States, there is no for)Tj 14.52869 0 TD -0.015 Tc (mal age limit to renal transplantation. There is some concer)Tj 24.78491 0 TD (n that as people get older)Tj 10.51969 0 TD 0 Tc (,)Tj -49.83329 -1.2 TD -0.015 Tc (there are more illnesses or medical conditions present that mak)Tj 26.27118 0 TD 0.025 Tw [(e the possibility of a successful transplant less lik)19(ely)116(.)]TJ -26.27118 -1.2 TD [(During the transplantation evaluation per)-18(for)-18(med on ever)-18(y applicant, there is a greater lik)19(elihood that there will be a)]TJ 0.0251 Tw (medical or surgical contraindication to transplantation \(such as cancer)' 28.77962 0 TD (, significant hear)Tj 6.73264 0 TD (t disease, etc.\). )Tj ET BT /F0 1 Tf 12 0 0 12 36 315.4346 Tm /CS0 cs 1 scn -0.0002 Tc 0.0278 Tw (What ar)Tj 3.602 0 TD 0 Tc 0.028 Tw [(e some of the signs and symptoms of PKD patients on dialysis, and how ar)18(e they)]TJ -3.602 -1.2 TD [(handled? How long can a patient r)18(emain on dialysis?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 276.1845 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(P)23(atients who are on hemodialysis typically dialyze three times a week. Hemodialysis or cleaning the blood is per)-17(for)-18(med in)]TJ 0 -1.2 TD [(three to four hours at each session. This process per)-18(for)-18(ms the work of the kidneys that usually tak)19(es place 24 hours a)]TJ 0 -1.19999 TD [(day)116(, 7 days a week. Because of the massive changes in blood chemistries and the volume of fluid that is removed during)]TJ 0 -1.2 TD [(the shor)-18(t time of dialysis, patients feel tired and drawn out af)18(ter their dialysis session. Of)-18(ten patients will tak)19(e a nap or)]TJ 0.0251 Tw (rest for the rest of the day following dialysis.)' 0 -2.39999 TD -0.0151 Tc (Another biochemical abnor)Tj 11.24877 -0.00001 TD -0.015 Tc (mality that occurs in renal failure in patients who receive dialysis is anemia or a low blood cell)Tj -11.24877 -1.19999 TD 0.025 Tw [(count. The kidney is a source of a hor)-18(mone called er)18(ythropoietin. This hor)-18(mone stimulates the bone mar)-19(row to mak)19(e)]TJ 0 -1.19998 TD -0.0151 Tc 0.0251 Tw (red cells and cor)Tj 6.82041 0.00001 TD (rect the anemia. V)Tj 7.64937 0.00001 TD -0.0148 Tc (er)Tj 0.85244 0.00001 TD -0.015 Tc (y little er)Tj 3.86717 0.00001 TD -0.0149 Tc (ythropoietin is made in patients in renal failure, and this results in anemia.)Tj -19.18939 -1.20002 TD -0.015 Tc (This accounts in par)Tj 8.31428 0.00001 TD (t for the fatigue, tiredness, lack of concentration, shor)Tj 22.10527 0.00001 TD (tness of breath and depression that a lot of)Tj -30.41955 -1.20001 TD 0.025 Tw [(renal failure patients experience. Er)-18(ythropoietin is now given to patients on dialysis regularly along with iron supplemen)1(-)]TJ 0 -1.2 TD 0.0251 Tw (tation to cor)Tj 5.09678 0.00001 TD -0.0151 Tc (rect the anemia. This process has allowed for higher hemoglobin levels and renal failure patients who are)Tj -5.09678 -1.2 TD -0.015 Tc (much more functional. )Tj 0 -2.4 TD (Hyperparathyroidism is another condition associated with renal failure. The parathyroid glands are next to the thyroid in)Tj 0 -1.2 TD -0.0151 Tc (the neck \(P)Tj 4.6465 0 TD -0.015 Tc (ARA-thyroid\). These glands respond to changes in calcium concentration in the blood. When calcium levels)Tj -4.6465 -1.2 TD 0.025 Tw [(go lower than nor)-18(mal \(which happens quite of)-18(ten in patients with renal insufficiency or in renal failure\), the parathyroid)]TJ ET BT /F0 1 Tf 9 0 0 9 461.1341 36.4268 Tm /CS0 cs 0.5 scn 0.2778 Tc 0.0278 Tw (Q&A on PKD)Tj 9.8731 0 Td 1 scn (25)Tj /F7 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj /F7 1 Tf 0.27802 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj ET Q endstream endobj 38 0 obj << /Length 6738 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F10 1 Tf 10 0 0 10 72 712.9834 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(glands work extra to tr)-18(y and bring the low calcium levels back to the nor)-18(mal range. Even though calcium levels improve,)]TJ 0 -1.2 TD 0.0251 Tw (other problems arise because the parathyroid hor)Tj 20.4763 0.00001 TD -0.0151 Tc (mone levels are maintained at too high a level. These problems include)Tj -20.4763 -1.19999 TD -0.015 Tc 0.025 Tw [(itchy skin or pr)-18(uritis, loss of matrix or bone from the sk)19(eleton, and deposits of cr)-18(ystallized calcium into sof)-19(t tissues of the)]TJ 0 -1.2 TD [(body)116(. The best way to cor)-18(rect this process is to maintain calcium levels in the nor)-18(mal range. This is typically done by)]TJ T* [(restricting the amount of phosphor)-18(us in the diet (see DIET) as well as by supplementing vitamin D sources that help)]TJ 0 -1.19999 TD -0.0151 Tc 0.0251 Tw (absorb calcium from the diet. )Tj 0 -2.4 TD -0.015 Tc 0.025 Tw [(Specific to ADPKD, these patients do ver)-18(y well on dialysis compared to the rest of the renal failure population. There are)]TJ 0 -1.20001 TD [(complications that occasionally arise related to ADPKD that include diver)-18(ticular disease and r)-18(upture or infection of cysts in)]TJ 0 -1.19999 TD [(the kidneys or liver)56(. It is impor)-18(tant for patients with ADPKD who develop fevers and abdominal pain to let their physi-)]TJ 0 -1.2 TD [(cians know immediately so that these potential complications can be investigated fur)-18(ther)56(. )]TJ ET BT /F0 1 Tf 12 0 0 12 72 555.434 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(Can peritoneal dialysis patients r)18(etur)-18(n to peritoneal dialysis after sever)17(e peritonitis?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 530.5839 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(P)42(eritoneal dialysis can be resumed af)-18(ter severe peritonitis. One of the problems that patients can face is that the sur)-18(face)]TJ 0 -1.2 TD [(area available for dialysis may diminish with an episode of peritonitis related to scar)-18(ring of the peritoneal sur)-18(face during)]TJ T* [(the infection. If the reduction in sur)-18(face area is significant enough, then there may not be adequate sur)-18(face for dialysis,)]TJ 0 -1.19999 TD [(and patients can then be under)37(-dialyzed. Given this, although most patients can retur)-18(n to dialysis af)-18(ter an episode of peri)1()]TJ 0 -1.20001 TD 0.0251 Tw (tonitis, sometimes there is membrane failure. )Tj ET BT /F0 1 Tf 12 0 0 12 72 445.0343 Tm /CS0 cs 1 scn -0.0002 Tc 0.0278 Tw (Is ther)Tj 2.89887 0 TD 0 Tc 0.028 Tw [(e anything a polycystic kidney patient being tr)18(eated with chr)17(onic ambulatory peri-)]TJ -2.89887 -1.2 TD [(toneal dialysis can take to incr)18(ease the blood pr)17(essur)18(e?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 405.7842 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(P)23(atients with all types of kidney diseases who are treated with dialysis, peritoneal or hemodialysis for chronic kidney)]TJ 0 -1.2 TD [(failure, occasionally experience periods of low blood pressure. P)42(olycystic kidney patients do not seem to be singled out in)]TJ 0.0251 Tw (this respect. Most commonly)' 12.05455 0 TD (, low blood pressure is caused by the loss of body fluids due to aggressive dialysis or because)Tj -12.05455 -1.19999 TD 0.025 Tw [(of intercur)-18(rent problems such as vomiting or diar)-18(rhea. In a few individuals, the blood pressure may be persistently)]TJ 0 -1.2 TD 0.0251 Tw (decreased despite adequate attention to body fluid status and the elimination of medications that might lower the blood)Tj T* 0.025 Tw [(pressure. Nephrologists will usually test for hear)-18(t failure, ner)-18(ve damage (neuropathy) or the interposition of other)]TJ 0 -1.19999 TD 0.0251 Tw (diseases such as amyloidosis or Addison\325s disease in the search for the cause of hypotension. Unfor)Tj 41.10749 0 TD -0.0149 Tc (tunately)Tj 3.17953 0 TD -0.0151 Tc (, there are a)Tj -44.28702 -1.20001 TD -0.015 Tc (few individuals in whom no cause can be found, and the nephrologist must resor)Tj 33.44541 0 TD (t to a trial of different medications that)Tj -33.44541 -1.2 TD -0.0151 Tc (may be of benefit. )Tj ET BT /F0 1 Tf 12 0 0 12 72 272.2346 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(What advice can you give on the car)18(e of arteriovenous grafts used for hemodialysis?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 247.3846 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Graf)-18(ts are trick)18(y things. Some become clotted early and repeatedly)117(. Others remain open for years. They become clotted)]TJ 0 -1.2 TD 0.0251 Tw (for a number of reasons \320 too much pressure on them \(par)Tj 24.47151 0.00001 TD (ticularly if you lie on that ar)Tj 11.26757 0.00001 TD (m at night\), decreased blood pres)Tj 13.94256 0.00001 TD 0 Tc (-)Tj -49.68164 -1.20002 TD -0.015 Tc (sure, abnor)Tj 4.68775 0.00001 TD (mal clotting mechanisms, and strictures that develop in the veins at the end of the graf)Tj 35.6787 0.00001 TD (ts, to name a few)Tj 6.8858 0.00001 TD -0.0151 Tc (. Many)Tj -47.25225 -1.20001 TD -0.015 Tc 0.025 Tw [(of these things are beyond control. Individuals should not allow prolonged pressure on the graf)-18(t or too tight clothing on)]TJ 0 -1.2 TD [(that ar)-18(m, for example. Blood pressure should not be tak)19(en in that ar)-19(m, unless the person taking it knows a lot about)]TJ -0.0149 Tc (graf)' 1.56059 0.00001 TD -0.015 Tc 0.0251 Tw (ts and has no other option but to tak)Tj 15.21175 0.00001 TD (e it in that ar)Tj 5.26456 0.00001 TD -0.0152 Tc (m. V)Tj 2.05739 0.00001 TD -0.015 Tc 0.025 Tw [(er)-18(y impor)-18(tantly)116(, it helps to adhere to the fluidmanagement)]TJ -24.09429 -1.20001 TD 0.0251 Tw (plan between dialysis treatments to avoid gaining a great deal of fluid weight. The fluid ingested between dialysis treat)Tj 48.70341 0.00001 TD 0 Tc (-)Tj -48.70341 -1.20001 TD -0.015 Tc (ments gradually seeps into the tissues. During dialysis, the fluid must come out of the blood vessels before any can move)Tj 0 -1.2 TD (from the tissues. The blood volume then becomes ver)Tj 22.58924 0.00001 TD -0.0151 Tc (y low)Tj 2.05427 0.00001 TD -0.015 Tc (, and may lead to clotting. Sometimes blood-thinning agents)Tj -24.64351 -1.20001 TD (are prescribed for those who have repeated clotting, especially when no strictures are found in the graf)Tj 42.43566 0.00001 TD -0.0149 Tc (t. )Tj ET BT /F0 1 Tf 9 0 0 9 40.4999 36.4268 Tm /CS0 cs 1 scn 0.2778 Tc 0.0278 Tw (26 )Tj 2.8349 0 Td 0.5 scn (Q&A on PKD)Tj /F7 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj /F7 1 Tf 0.27802 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj ET Q endstream endobj 39 0 obj << /Length 6009 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 12 0 0 12 36 711.4336 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (I am a PKD dialysis patient. I have incessant nausea, which my doctor feels is caused by)Tj 0 -1.2 TD 0 Tc 0.028 Tw [(the liver and kidney cysts. Is ther)18(e anything to r)17(elieve the nausea? )]TJ ET BT /F10 1 Tf 10 0 0 10 36 672.1835 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(P)23(atients on dialysis may have nausea for a variety of reasons, such as insufficient dialysis, too much acid production by the)]TJ 0 -1.2 TD [(lining of the stomach, or neuropathy caused by renal failure. A mark)19(edly enlarged polycystic kidney or liver can press on)]TJ 0 -1.19999 TD -0.0151 Tc 0.0251 Tw (the stomach. As a result, patients may feel full with small meals, have frequent hear)Tj 34.3934 0.00001 TD -0.015 Tc 0.025 Tw [(tbur)-18(n, and vomit easily)116(. These organs)]TJ -34.3934 -1.20001 TD [(can compress the inferior vena cava \(the vein retur)-18(ning the blood to the hear)-18(t\), which can cause low blood pressure)]TJ T* [(during dialysis and may be associated with nausea. W)19(ithout having a better idea about the cause of your nausea, we)]TJ 0 -1.19999 TD 0.0251 Tw (cannot give you more specific recommendations. Sometimes physicians cannot find or solve the cause of the nausea, and)Tj 0 -1.2 TD (antinauseant medications are prescribed. )Tj ET BT /F0 1 Tf 12 0 0 12 36 562.634 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(How do polycystic kidney disease patients do on various forms of dialysis as compar)18(ed to)]TJ 0 -1.2 TD -0.0001 Tc (transplantation?)Tj ET BT /F10 1 Tf 10 0 0 10 36 523.3839 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(ADPKD patients tend to do better on dialysis than other patients with other kidney diseases. F)42(or example, patients with)]TJ 0 -1.2 TD [(diabetes do not sur)-18(vive as long on dialysis as patients with ADPKD. The leading cause of death in ADPKD patients,)]TJ T* [(whether they are receiving hemodialysis, peritoneal dialysis or a transplant, is cardiovascular or cerebrovascular)56(. Even)]TJ T* [(though ADPKD patients do better than other types of patients on dialysis, their sur)-18(vival is improved with a kidney trans)1(-)]TJ T* [(plant. There are complications in dialysis that are specific to ADPKD patients. Impor)-18(tantly)116(, as ADPKD individuals sur)-18(vive)]TJ T* [(longer)56(, complications of liver cystic disease become more common. Complications include liver cyst hemor)-18(rhage, liver)]TJ 0 -1.19999 TD [(cyst infection and biliar)-18(y stone disease. As well, in ADPKD individuals who undergo peritoneal dialysis, the development)]TJ 0 -1.2 TD [(of inguinal or ventral her)-18(nias becomes more common. If the ventral her)-18(nia becomes big enough, it may be impossible to)]TJ -0.0149 Tc 0.0251 Tw (undergo peritoneal dialysis. )' 0 -2.39999 TD -0.015 Tc 0.025 Tw [(ADPKD patients tolerate transplantation ver)-18(y well. The complications that they endure are the same as other renal)]TJ 0 -1.2 TD 0.0251 Tw (patients, with the exception that post-transplant lymphocoeles are more common in ADPKD patients.)Tj ET BT /F0 1 Tf 12 0 0 12 36 353.8345 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (Will polycystic kidney disease attack a newly transplanted kidney)Tj 30.24621 0 TD (, and what is the survival)Tj -30.24621 -1.2 TD (rate of transplants in patients with polycystic kidney disease?)Tj ET BT /F10 1 Tf 10 0 0 10 36 314.5844 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(There is no evidence that polycystic kidney disease occurs in a transplanted kidney)116(. This is expected, since ADPKD is)]TJ 0 -1.2 TD [(inherited and a transplanted kidney would not be lik)19(ely to contain the genetic abnor)-18(mality)116(. Sur)-18(vival rates following kidney)]TJ 0 -1.19999 TD 0.0251 Tw (transplantation in patients with polycystic kidney disease are similar to all other patients undergoing transplantation. In)Tj 0 -1.2 TD (fact, 80 percent to 85 percent of kidney recipients can expect a oneyear sur)Tj 31.20828 0.00001 TD (vival of the kidney transplant from a cadaver)Tj -31.20828 -1.20001 TD -0.0147 Tc (donor)Tj 2.47741 0.00001 TD -0.0151 Tc (. )Tj ET BT /F0 1 Tf 12 0 0 12 36 229.0348 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (Should a cadaver kidney transplant be performed in a patient with ADPKD prior to the)Tj 0 -1.2 TD (need for dialysis?)Tj ET BT /F10 1 Tf 10 0 0 10 36 189.7847 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(T)135(ransplantation with kidneys from recently deceased, unrelated persons is frequently per)-18(for)-18(med on PKD patients and is as)]TJ 0 -1.19999 TD [(successful or more successful than cadaveric transplants in general. Many transplant centers do not lik)19(e to per)-18(for)-18(m trans-)]TJ 0 -1.2 TD 0.0251 Tw (plants or put patients on the cadaveric transplant waiting list until their renal disease is advanced enough to require)Tj (dialysis. This policy has multiple reasons, not the least of which is the shor)' 30.84729 0.00001 TD (tage of cadaver donor organs for people who)Tj -30.84729 -1.19999 TD 0.025 Tw [(are already waiting on dialysis. Also, it is of)-18(ten a good idea to have a trial of dialysis, since many patients feel much)]TJ 0 -1.2 TD 0.0251 Tw (improved and thus go into transplantation psychologically better prepared to face the 15 percent to 20 percent rejection)Tj (rate of cadaver organs. )' 0 -2.4 TD (A PKD gene has been located on chromosome 16. Can you tell me why that gene would not affect a transplanted kidney?)Tj 0 -1.2 TD 0.025 Tw [(W)79(e do not know how the abnor)-18(mal gene on chromosome 16 causes cysts to for)-18(m in patients with polycystic kidney)]TJ ET BT /F0 1 Tf 9 0 0 9 461.1341 36.4268 Tm /CS0 cs 0.5 scn 0.2778 Tc 0.0278 Tw (Q&A on PKD)Tj 9.8731 0 Td 1 scn (27)Tj /F6 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj ET Q endstream endobj 40 0 obj << /Length 6522 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F10 1 Tf 10 0 0 10 72 712.9834 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(disease, but if polycystic kidney disease is caused by an abnor)-18(mal substance in the blood, one might expect that cysts)]TJ 0 -1.2 TD -0.0149 Tc 0.0251 Tw (would for)Tj 4.00402 0.00001 TD -0.015 Tc (m in a kidney transplanted from a non-related person. The experience of many transplant surgeons and)Tj -4.00402 -1.19999 TD -0.0149 Tc (nephrologists indicates that cystic disease does not recur in kidneys transplanted into polycystic patients from individuals)Tj 0 -1.2 TD -0.015 Tc (who do not have polycystic kidney disease. This \322experiment in nature\323 shows that polycystic kidney disease does not)Tj T* 0.025 Tw [(recur in a non-related transplanted kidney and that polycystic kidney disease is probably not due to an abnor)-18(mal factor)]TJ 0 -1.19999 TD 0.0251 Tw (circulating in the blood. )Tj ET BT /F0 1 Tf 12 0 0 12 72 615.4338 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(A patient with advanced polycystic kidney disease r)18(equir)17(es a kidney transplant. Her 39-)]TJ 0 -1.2 TD [(year)55(-old sister has only two small cysts in the liver and none in the kidney \(shown by)]TJ T* [(contrast-enhanced CT\). W)18(ould she be an acceptable donor of a kidney for her sister?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 561.7838 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(This is a difficult question. It is most common to find kidney cysts develop, before liver cysts. Liver cysts do occur)56(,)]TJ 0 -1.2 TD [(although infrequently)116(, in the general population. If this individual\325s liver cysts were numerous and large, one would be)]TJ T* [(hesitant to recommend that she donate a kidney)116(. If this family had other affected members and could be tested for PKD)-36(-1)]TJ 0 -1.19999 TD [(by gene-linkage analysis that would be the first step to tr)-18(y)116(. If gene testing is not a possibility)116(, one could look for other)]TJ 0 -1.20001 TD [(mark)18(ers of PKD in the potential donor)-36(\325s sister)56(, such as inability of the sister to concentrate her urine when she does not)]TJ 0 -1.2 TD [(have access to water)56(, looking for other extra-renal signs of PKD such as mitral valve prolapse and the presence of hyper-)]TJ 0 -1.19999 TD 0.0251 Tw (tension. If the sister who is a potential donor has high blood pressure, inability to concentrate her urine, or mitral valve)Tj 0 -1.2 TD 0.025 Tw [(prolapse, that would increase the lik)19(elihood that she has the gene and mak)18(es her a less-lik)19(ely donor)56(. )]TJ ET BT /F0 1 Tf 12 0 0 12 72 440.2343 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (My dad has PKD, and I also have the disease. I am the only child of four who has been)Tj 0 -1.2 TD 0 Tc 0.028 Tw [(diagnosed as having the disease. Can I have a kidney fr)18(om one of my sisters or br)17(others)]TJ 0 -1.19999 TD -0.0001 Tc 0.0278 Tw (if needed?)Tj ET BT /F10 1 Tf 10 0 0 10 72 386.5842 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Each of your sisters and brothers has a 50/50 chance of having inherited PKD as you did. P)24(atients older than 20 years of)]TJ 0 -1.19999 TD 0.0251 Tw (age will exhibit PKD when examined by computed tomography scanning (CT scanning), when the test is done with)Tj 0 -1.2 TD (contrast enhancement. This is the most sensitive diagnostic test we know of with the exception of genetic-linkage test. In)Tj T* 0.025 Tw [(a family with PKD, the genetic-linkage test can deter)-18(mine whether asymptomatic individuals have the gene, ir)-18(respective of)]TJ 0 -1.19999 TD [(whether the X)74(-ray tests show positive. Unfor)-18(tunately)116(, this gene test is only available in a few genetic-counseling centers in)]TJ 0 -1.2 TD -0.0149 Tc 0.0251 Tw (the United States.)Tj ET BT /F0 1 Tf 12 0 0 12 72 289.0347 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(Do the immunosuppr)18(essive drugs used to tr)17(eat transplant r)18(ejection, specifically pr)18(ed)-1(-)]TJ 0 -1.2 TD [(nisone and cyclosporine, have any ef)18(fect on the underlying polycystic kidney disease?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 249.7846 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (Prednisone and cyclosporine both increase blood pressure. Increased blood pressure can have deleterious effects on the)Tj 0 -1.2 TD -0.0149 Tc (transplanted kidney)Tj 8.03549 0.00001 TD -0.015 Tc (. Impor)Tj 3.08737 0.00001 TD 0.025 Tw [(tantly)116(, cyclosporine is toxic to the kidney when given in too great amounts. This can result in)]TJ -11.12286 -1.20001 TD 0.0251 Tw (renal failure if excessive dosing is prolonged. In ADPKD individuals, transplantation occurs once their polycystic kidneys)Tj 0 -1.19999 TD -0.0149 Tc (have stopped functioning. Any effects of the immunosuppression on kidney function at this point are not of significance.)Tj 0 -1.2 TD -0.015 Tc 0.025 Tw [(However)56(, there have been repor)-18(ts of rapid growth of the polycystic kidney post-transplantation. )]TJ 0 -2.39999 TD [(R)-18(arely)115(, ADPKD individuals with intact kidney function will undergo liver transplantation. As well, autosomal recessive)]TJ 0 -1.2 TD [(polycystic kidney disease patients (ARPKD) will undergo liver transplantation in the setting of relatively nor)-18(mal renal func-)]TJ 0.0251 Tw (tion. Prednisone and cyclosporine \(or cyclosporine-lik)' 22.20261 0.00001 TD -0.0148 Tc (e dr)Tj 1.66088 0.00001 TD -0.0149 Tc (ugs\) are used for immunosuppression for other organ)Tj -23.86349 -1.2 TD -0.015 Tc 0.025 Tw [(transplants such as the liver or hear)-18(t. This could hypothetically impact disease progression in the polycystic kidney)116(.)]TJ T* [(Prednisone will increase blood pressure by increasing the kidney)36(\325s avidity for salt as well as increasing appetite and)]TJ 0.0251 Tw (weight. Cyclosporine, by acting directly on the blood vessels to the kidneys, causes a decrease in blood flow and)' T* 0.025 Tw [(increases blood pressure. Increased blood pressure is associated with disease progression in ADPKD. In the experi)1(-)]TJ 0.0251 Tw (mental animal models of ADPKD, prednisone therapy has been associated with disease progression and renal cyst growth.)' T* 0.025 Tw [(In humans this has not been repor)-18(ted. )]TJ ET BT /F0 1 Tf 9 0 0 9 40.4999 36.4268 Tm /CS0 cs 1 scn 0.2778 Tc 0.0278 Tw (28 )Tj 2.8349 0 Td 0.5 scn (Q&A on PKD)Tj /F7 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj /F7 1 Tf 0.27802 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj ET Q endstream endobj 41 0 obj << /Length 6342 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 12 0 0 12 36 711.4336 Tm /CS0 cs 1 scn 0.028 Tw [(If a PKD patient had cancer)92(, underwent tr)17(eatment and was cancer)55(-fr)18(ee for two years,)]TJ 0 -1.2 TD [(would this eliminate the patients fr)18(om being a transplant candidate due to the use of anti-)]TJ 0 -1.19999 TD [(r)18(ejection drugs?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 657.7835 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(The reason for the required time delay af)-18(ter treatment for cancer before being eligible for transplantation is that immuno-)]TJ 0 -1.19999 TD 0.0251 Tw (suppressive medicines used to prevent the transplant kidney from being rejected allow cancer cells to multiply more)Tj 0 -1.2 TD 0.025 Tw [(rapidly and for cancer to grow and spread more quickly)116(. It is ver)-18(y impor)-18(tant to mak)19(e sure that there is no cancer in the)]TJ T* [(body prior to receiving an organ transplant that requires immunosuppressive therapy)117(. The required cancer)37(-free time prior)]TJ 0 -1.19999 TD 0.0251 Tw (to being eligible for a kidney transplant is the same for someone with ADPKD as it is with any other renal disease.)Tj 0 -1.2 TD 0.025 Tw [(Depending on the type of cancer)56(, the minimum time required prior to being eligible for transplantation is two years. F)42(or)]TJ 0 -1.20001 TD [(example, for a successfully treated case of lymphoma, 2 years is the minimum time required. Renal cell cancer sur)-18(vivors)]TJ 0 -1.19999 TD [(require 4-5 years prior to being eligible, those with colon cancer 5-10 years. Non-invasive squamous or basal cell carci)1(-)]TJ 0 -1.2 TD [(noma can be considered eligible almost immediately af)-18(ter removal; however)56(, melanoma, regardless of the degree of)]TJ T* [(invasion or the stage of disease, requires 10 years prior to eligibility)116(. These time requirements var)-18(y somewhat between)]TJ -0.0149 Tc 0.0251 Tw (transplantation centers. )' ET BT /F0 1 Tf 12 0 0 12 36 500.2341 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(While r)18(enal transplantation has become a highly successful tr)17(eatment for r)18(enal failur)18(e, the)]TJ 0 -1.19999 TD -0.0001 Tc 0.0278 Tw (number of persons waiting and the time they have to wait for a kidney fr)Tj 33.48445 0 TD (om a cadaver has)Tj -33.48445 -1.2 TD 0 Tc 0.028 Tw [(been incr)18(easing because too few human organs ar)17(e available. How close ar)18(e transplant)]TJ -0.0001 Tc 0.0278 Tw (surgeons to being able to use pig kidneys for transplantation?)' ET BT /F10 1 Tf 10 0 0 10 36 432.1841 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(T)135(ransplanting an organ from one species to another is called xenotransplantation. There are body components used)]TJ 0 -1.2 TD 0.0251 Tw (from other species that are implanted into humans; for example, pig or porcine valves are placed in the hear)Tj 44.67756 0 TD (t for valve)Tj -44.67756 -1.19999 TD 0.025 Tw [(replacement procedures, and brain cells from pigs are injected into the human brain for the treatment of P)24(arkinson\325s)]TJ 0 -1.2 TD 0.0251 Tw (disease. A)Tj 4.26388 0 TD (t the present, there is no immediate plan for the use of other specie\325s kidneys for transplantation into humans. )Tj ET BT /F0 1 Tf 12 0 0 12 36 358.6345 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (I am looking for help and information concer)Tj 20.64078 0 TD (ning a kidney transplant in the case of an)Tj -20.64078 -1.2 TD 0 Tc 0.028 Tw [(antithr)18(ombin-3 deficiency)91(. At first, my doctor gave me all the indications that a transplant)]TJ 0 -1.19999 TD -0.0001 Tc 0.0278 Tw (would be a good bet. Then, he said he would not place me on the waiting list, because)Tj 0 -1.2 TD (the transplant doctor would not consider doing the surgery)Tj 27.33508 0 TD -0.0002 Tc (. I am not going to lose hope,)Tj -27.33508 -1.2 TD -0.0001 Tc (and that is why I am asking for information.)Tj ET BT /F10 1 Tf 10 0 0 10 36 276.1845 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Antithrombin-3 deficiency is a condition that leads to clotting of the blood. Of)-18(ten, medications are used to prevent the)]TJ 0 -1.2 TD [(clotting from occur)-18(ring that mak)18(e any type of surger)-18(y more difficult. Cur)-18(rently there is no contraindication to trans)1()]TJ 0 -1.19999 TD [(planting a kidney in someone with this deficiency)116(, as long as the surgeons can prepare properly for the procedure.)]TJ 0 -1.2 TD [(Kidney transplantation is not a curative procedure for this illness, however)56(. )]TJ ET BT /F0 1 Tf 12 0 0 12 36 202.6348 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw (Is it possible to be placed on multiple cadaver transplant lists in several geographic loca-)Tj 0 -1.2 TD [(tions? If a kidney came up at a site r)18(emote fr)17(om the patient, would the patient go to the)]TJ 0 -1.19999 TD [(kidney)92(, or the kidney come to the patient?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 148.9848 Tm 0 0 0 1 k -0.02 Tc 0.025 Tw [(Most of)-18(ten the patient, goes to the kidney)116(. There are transplant centers that are link)19(ed together that deter)-18(mine which)]TJ 0 -1.19999 TD [(center the kidney should go to. However)56(, it is still required to go to the transplant center)56(. It is possible to be placed on)]TJ 0 -1.2 TD 0.0251 Tw (multiple transplant lists in several geographical locations to improve the chances of receiving a kidney transplant. Each)Tj T* 0.025 Tw [(transplant center has its own r)-18(ules with regard to the maximum distance away that a patient can be. This is based on the)]TJ -0.0201 Tc 0.0251 Tw (time that it tak)' 5.9253 0 TD -0.02 Tc (es for the patient to get to the transplant center to receive the kidney once contacted. Usually the maximum)Tj -5.9253 -1.2 TD -0.0201 Tc (time allowed from the center is seven hours. The longer that a kidney waits to be placed into a recipient, the more lik)Tj 48.06184 0.00001 TD -0.02 Tc (ely it)Tj -48.0618 -1.2 TD (is that there will be a longer phase of non-function at the time of transplantation or that the kidney could fail. )Tj ET BT /F0 1 Tf 9 0 0 9 461.1341 36.4268 Tm /CS0 cs 0.5 scn 0.2778 Tc 0.0278 Tw (Q&A on PKD)Tj 9.8731 0 Td 1 scn (29)Tj /F6 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj ET Q endstream endobj 42 0 obj << /Length 6286 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 18 0 0 18 72 707.1504 Tm /CS0 cs 0.5 scn 0.028 Tw [(Diet, Drugs, Surgery)92(, Exer)17(cise)]TJ 12 0 0 12 72 668.2337 Tm 1 scn [(Some herbs ar)18(e said to be danger)17(ous to patients with PKD. Can you pr)18(ovide a list of)]TJ 0 -1.2 TD -0.0001 Tc 0.0278 Tw (herbs and other substances used as foods that might be harmful to polycystic kidneys?)Tj ET BT /F10 1 Tf 10 0 0 10 72 628.9835 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (Slimming preparations can cause kidney damage, as can various compound mixtures with multiple ingredients, which)Tj 0 -1.2 TD 0.025 Tw [(include toxic, non-steroidal, anti-inflammator)-18(y dr)-18(ugs. Some slimming medications include water pills or diuretic-lik)19(e)]TJ 0 -1.19999 TD [(substances. These can cause electrolyte abnor)-18(malities as well as dehydration. Some slimming medications will drive the)]TJ 0 -1.2 TD [(sympathetic ner)-18(vous system. These can be dangerous and should only be tak)19(en under the super)-18(vision of a physician.)]TJ T* [(Licorice root in chronic use can cause sodium and water retention and potassium loss, which can result in hyper)-18(tension,)]TJ 0 -1.19999 TD -0.0151 Tc 0.0251 Tw (edema and hypokalemia. Chinese herbs such as aristolochic acid are toxic to kidneys and should be avoided. The best)Tj 0 -1.2 TD -0.015 Tc 0.025 Tw [(course to follow is to know the ingredients of anything you tak)19(e medicinally and to clear the preparation with your )]TJ (physician.)' ET BT /F0 1 Tf 12 0 0 12 72 507.4341 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(What is the pr)18(oper diet for a patient with ADPKD to pr)17(event the pr)18(ogr)17(ession to end-stage)]TJ 0 -1.19999 TD [(r)18(enal failur)18(e?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 468.184 Tm 0 0 0 1 k -0.0149 Tc 0.0251 Tw (Protein restriction star)Tj 9.17277 0 TD -0.015 Tc 0.025 Tw [(ted at an early stage of the disease has clearly shown to have a protective effect on cyst develop)1(-)]TJ -9.17277 -1.19999 TD 0.0251 Tw (ment and renal function in two animal models of polycystic kidney disease: the Han:SPRD rats and the pcy mouse.)Tj 0 -1.2 TD 0.025 Tw [(However)56(, the evidence for a protective effect in humans is less convincing. The largest study)116(, Modification of Diet in Renal)]TJ 0.0251 Tw (Disease or MDRD trial, showed that a diet containing 0.58 gm/kg/body weight (bw) had no beneficial effect, as compared)' (to 1.3 gm/kg/bw in 220 ADPKD patients with moderately advanced renal insufficiency for approximately 24 months. This)' 0 -1.19999 TD 0.025 Tw [(result, however)56(, is not conclusive because of the shor)-18(t period of obser)-18(vation and the fact that patients seen in this study)]TJ 0 -1.2 TD 0.0251 Tw (already had moderately advanced renal insufficiency)Tj 21.30298 0 TD (. Until more infor)Tj 7.43428 0 TD -0.0151 Tc (mation becomes available, it seems pr)Tj 15.61765 0 TD -0.0149 Tc (udent that)Tj -44.35491 -1.20001 TD -0.015 Tc 0.025 Tw [(patients with ADPKD avoid protein in excess of the RD)37(A for nor)18(mal adults (0.8 gm/kg/bw). While protein intak)19(e should)]TJ 0 -1.19999 TD [(not be greater than the 1 gm/kg/bw)111(, severe restriction with consequent protein malnutrition is also not desirable. F)43(or all)]TJ 0 -1.2 TD [(patients, par)-18(ticularly children, adequate amounts of fr)-18(uits, vegetables, and minerals are desirable. The D)37(ASH Diet \(Dietar)18(y)]TJ T* [(Approaches to Stop Hyper)-18(tension\) is cur)-18(rently being advocated for ADPKD. This diet can be found at the NIH \(National)]TJ 0 -1.19999 TD 0.0251 Tw (Institute of Health\) website.)Tj ET BT /F0 1 Tf 12 0 0 12 72 298.6346 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(How much pr)18(otein does my body need? )]TJ ET BT /F10 1 Tf 10 0 0 10 72 273.7845 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (Most Americans eat much more protein than they need. Many Americans eat 2 or 3 times the protein that their body)Tj 0 -1.19999 TD 0.025 Tw [(needs to stay healthy)116(. Any excess protein from the diet is not stored in the body lik)19(e other nutrients such as fat or carbo-)]TJ 0 -1.2 TD [(hydrate but excreted by the kidneys in the for)-18(m of urea. Minimum dietar)-18(y protein needs for healthy adults to avoid)]TJ -0.0149 Tc 0.0251 Tw (protein malnutrition var)' 9.89665 0.00001 TD -0.015 Tc (y between 0.45 to 0.6 gm/kg/bw)Tj 12.95967 0.00001 TD 0.025 Tw [(. The cur)-18(rent recommendation for dietar)-18(y protein intak)18(e in the)]TJ -22.85632 -1.20001 TD [(general adult population is 0.8 gm/kg/bw)112(. The recommendation for ADPKD patients is 0.6-0.8 gm protein/kg/bw)111(, which is)]TJ 0 -1.19999 TD 0.0251 Tw (an appropriate goal for the general population. The recommendation for children is much higher to allow for appropriate)Tj 0 -1.2 TD 0.025 Tw [(growth and ranges from 1.8-2.2 gm/kg/day)116(.)]TJ ET BT /F0 1 Tf 12 0 0 12 72 161.835 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(Recent r)18(esear)17(ch in ADPKD animal models suggests soy pr)18(otein may have a beneficial)]TJ 0 -1.2 TD [(ef)18(fect on delaying the pr)17(ogr)18(ess of r)17(enal disease. Does this mean I should eat a lot of soy?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 122.5849 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(The statement \322eating a lot of soy)-37(\323 only means that you can eat as much soy as you wish as long as you stay within the)]TJ 0 -1.2 TD -0.0149 Tc 0.0251 Tw (guidelines for total protein intak)Tj 13.25786 0.00001 TD -0.015 Tc (e. Soy protein should be counted as par)Tj 16.72393 0.00001 TD 0.025 Tw [(t of your protein allowance. A)19(t this point, the)]TJ -29.9818 -1.2 TD [(safe recommendation is to substitute soy products for animal protein \(meat and dair)-18(y products\). Soy protein has been)]TJ T* [(shown to have increased benefit over other for)-18(ms of protein in animal models of polycystic kidney disease. The effect)]TJ ET /GS0 gs 1 w /CS0 CS 1 SCN 72 698.9839 m 576 698.9839 l S /GS2 gs BT /F0 1 Tf 9 0 0 9 40.4999 36.4268 Tm /CS0 cs 1 scn 0.2778 Tc 0.0278 Tw (30 )Tj 2.8349 0 Td 0.5 scn (Q&A on PKD)Tj /F6 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj ET Q endstream endobj 43 0 obj << /Length 6001 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F10 1 Tf 10 0 0 10 36 712.9834 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (was moderate. Research is being conducted to delineate the specific beneficial components in the soy proteins that retard)Tj 0 -1.2 TD (PKD. Phytoestrogens were once thought to be the beneficial compound, but research has deter)Tj 39.69466 0.00001 TD (mined that this is not the)Tj -39.69466 -1.19999 TD 0.025 Tw [(case. Cur)-18(rently)116(, sapsonin B is being investigated, and if found to be beneficial, will be cer)-18(tainly tested fur)-18(ther in humans)]TJ 0 -1.2 TD -0.0151 Tc 0.0251 Tw (with ADPKD. )Tj ET BT /F0 1 Tf 12 0 0 12 36 639.4338 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(How do I figur)18(e out the amount of pr)17(otein I should eat? )]TJ ET BT /F10 1 Tf 10 0 0 10 36 614.5837 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(F)19(irst, conver)-19(t your weight to kilograms \(kg\) by dividing your weight in pounds \(lb\) by 2.2. \(Example: if you weigh 154 lb,)]TJ 0 -1.20001 TD -0.0149 Tc 0.0251 Tw (and divide by 2.2, you get 70 kg\))Tj 0 -2.4 TD -0.015 Tc 0.025 Tw [(Next, multiply your weight in kg. by 0.8 to find the upper range of protein that you should eat/day)117(. \(Example: 70 kg multi-)]TJ 0 -1.19999 TD -0.0149 Tc 0.0251 Tw (plied by 0.8 = 56 gm of protein\))Tj 0 -2.4 TD -0.015 Tc 0.025 Tw [(T)135(o find the lower range, multiply your weight in kg by 0.6. \(Example: 70 kg multiplied by 0.6 = 42 gm protein/day at a)]TJ 0 -1.19999 TD -0.0149 Tc (minimum\))Tj ET BT /F0 1 Tf 12 0 0 12 36 493.0342 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(Does the quality of pr)18(otein we eat matter?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 468.184 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (The whole idea of eating protein of high quality means you can eat all of the essential amino acids your body needs)Tj 0 -1.19999 TD (without eating excess amounts of non-usable protein that put stress on your kidneys to eliminate additional waste. The)Tj 0 -1.2 TD 0.025 Tw [(quality of the protein you eat is impor)-18(tant especially if you are planning to reduce the amount of protein in your diet.)]TJ T* [(Highest quality protein (high-biological-value protein) can be found in animal products such as eggs, chick)19(en, fish, turk)19(ey)]TJ -0.0149 Tc 0.0251 Tw (and dair)' 3.38407 0 TD -0.015 Tc (y products. While red meat such as beef and pork (also considered the other white meat!) also have high-quality)Tj -3.38407 -1.19999 TD 0.025 Tw [(protein, they should be consumed to a lesser extent because of their higher saturated fat content. The por)-18(tion size of)]TJ 0 -1.2 TD 0.0251 Tw (meat eaten at a meal should also be small, around 2 to 3 ounces per ser)Tj 29.53759 0 TD (ving. This will put less bolus stress on the kidney)Tj 20.19832 0 TD 0 Tc (.)Tj -49.73591 -1.20001 TD -0.015 Tc (Whole eggs contain high-quality protein, but the yolk contains high levels of cholesterol. Therefore, if your cholesterol)Tj 0 -1.19999 TD 0.025 Tw [(level is high, it would be impor)-18(tant to check with your physician or dietician first before eating eggs ever)-18(y day)116(. Dair)-18(y prod-)]TJ 0 -1.2 TD [(ucts should be low fat or skim \(a better alter)-18(native would be to substitute soy for dair)-18(y\). Animal sources are not the only)]TJ 0.0251 Tw (foods containing high-biological-value protein soybean products, potatoes, mushrooms and broccoli are plant sources of)' 0 -1.19999 TD (high-biological-value protein and have the added benefit of fiber and of being \322hear)Tj 34.30941 0 TD 0.025 Tw [(t healthy)-37(\323 \(low in fat, cholesterol and)]TJ -34.30941 -1.2 TD -0.0149 Tc 0.0251 Tw (saturated fat\).)Tj ET BT /F0 1 Tf 12 0 0 12 36 286.6347 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(My wife has been tr)18(eated over the past 15 years or so for polycystic kidney disease.)]TJ 0 -1.2 TD [(Lately)92(, she has been, with the consent of her nephr)17(ologist, using fish oil supplements as)]TJ 0 -1.19999 TD -0.0001 Tc 0.0278 Tw (well as flax seed. Do you know of any r)Tj 18.48659 0 TD -0.0002 Tc (esear)Tj 2.52051 0 TD -0.0001 Tc (ch showing benefits to patients who use flax)Tj -21.0071 -1.20001 TD (seed or fish oil? )Tj ET BT /F10 1 Tf 10 0 0 10 36 218.5847 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Investigators in Canada have demonstrated the value of dietar)-18(y fish and flax oils in a number of renal diseases in experi-)]TJ 0 -1.2 TD [(mental animals. F)19(ish oil and flax oil are excellent sources of a type of fatty acids (omega-3-fatty acids) which are thought)]TJ 0.0251 Tw (to have anti-hyper)' 7.47092 0.00001 TD (tensive, lipid-lowering and anti-inflammator)Tj 17.88436 0.00001 TD 0.025 Tw [(y effects. F)19(ish oil, however)55(, did not have a beneficial effect)]TJ -25.35528 -1.20001 TD 0.0251 Tw (on early disease progression in a strain of mice with polycystic kidney disease (pcy mice). Histologic studies revealed that)Tj 0 -1.2 TD 0.025 Tw [(flaxseed feeding in the Han:SPRD)-37(-cy rat was associated with a modest reduction in cyst change. )]TJ ET BT /F0 1 Tf 12 0 0 12 36 133.0351 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(What is the pr)18(oper amount of phosphate in the diet, and what is the thinking about)]TJ 0 -1.2 TD -0.0001 Tc 0.0278 Tw (calcium supplementation, vitamins, and water intake?)Tj ET BT /F10 1 Tf 10 0 0 10 36 93.7849 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(This type of dietar)-18(y prescription needs to be highly individualized among patients. Phosphate in the diet usually comes in)]TJ 0 -1.2 TD [(the for)-18(m of protein and dair)-18(y products; therefore, if you reduce protein and dair)-18(y products, you will be reducing the)]TJ ET BT /F0 1 Tf 9 0 0 9 461.1341 36.4268 Tm /CS0 cs 0.5 scn 0.2778 Tc 0.0278 Tw (Q&A on PKD)Tj 9.8731 0 Td 1 scn (31)Tj /F7 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj /F7 1 Tf 0.27802 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj /F7 1 Tf 0.27802 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj ET Q endstream endobj 44 0 obj << /Length 6204 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F10 1 Tf 10 0 0 10 72 712.9834 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(dietar)-18(y phosphor)-18(us. A cer)-18(tain amount of these minerals is necessar)-19(y to prevent protein malnutrition. W)19(ith kidney)]TJ 0 -1.2 TD 0.0251 Tw (dysfunction, phosphate may be retained because of the failure of the kidney to excrete it. Under these circumstances, it)Tj 0 -1.19999 TD 0.025 Tw [(needs to be restricted in the diet. In some patients, as kidney dysfunction advances, they may need to tak)19(e phosphate)]TJ 0 -1.2 TD [(binders in the for)-18(m of calcium salts.)]TJ 0 -2.39999 TD [(Calcium is a necessar)-18(y ingredient for our bone health and life. It is best obtained in proper amounts of dair)-18(y products.)]TJ 0 -1.2 TD [(The recommended daily allowance of calcium is approximately 1 gm (1000 mg) of elemental calcium per day)117(. F)41(or dialysis)]TJ T* [(patients, calcium supplements (1-1.5 gm/day) should be tak)19(en between meals. If your dietar)-18(y prescription avoids dair)-18(y)]TJ 0 -1.20001 TD 0.0251 Tw (products, calcium supplements are a convenient way to get the calcium that you need. There is no evidence that calcium)Tj 0 -1.19999 TD 0.025 Tw [(supplements cause increased kidney stones. As a matter of fact, calcium in the diet may bind cer)-18(tain ingredients that are)]TJ 0 -1.2 TD [(more impor)-18(tant in causing stones.)]TJ 0 -2.39999 TD [(Vitamins should be tak)19(en in moderation. Vitamins ingested beyond the body)-37(\325s metabolic needs must be excreted by the)]TJ 0 -1.2 TD [(kidney)116(. High doses of vitamin C should not be used by patients who are stone-for)-18(mers or have renal insufficiency)117(.)]TJ T* [(P)23(atients with recur)-18(rent kidney stones are advised to limit their daily vitamin C intak)19(e to 100-200 mg, because subsets of)]TJ 0 -1.19999 TD [(these patients may be more susceptible to increased oxalate production due to metabolic defects. P)24(atients with chronic)]TJ 0 -1.2 TD [(renal insufficiency should also avoid large doses of vitamin C because deposition of calcium oxalate cr)-18(ystals in the kidneys)]TJ 0 -1.20001 TD 0.0251 Tw (and other tissues occurs commonly in patients with chronic renal failure.)Tj 0 -2.39999 TD 0.025 Tw [(W)79(ater intak)18(e needs to be varied, depending on the patient\325s urine output and body needs in general. A higher water)]TJ 0 -1.2 TD [(intak)19(e protects against kidney stones.)]TJ 0 -2.39999 TD [(F)42(or all of these ingredients, it is best to individualize. These are issues to be discussed with your nephrologist or renal)]TJ 0 -1.2 TD [(dietitian so the diet is tailored to your par)-18(ticular needs. A good general r)-18(ule, though, is moderation in ever)-18(ything.)]TJ ET BT /F0 1 Tf 12 0 0 12 72 399.4344 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (What is the r)Tj 5.87974 0 TD -0.0002 Tc (ole of sodium r)Tj 6.95543 0 TD -0.0001 Tc (estriction in the management of patients with polycystic)Tj -12.83517 -1.2 TD (kidney disease?)Tj ET BT /F10 1 Tf 10 0 0 10 72 360.1843 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(When kidney function is compromised, restriction of dietar)-18(y sodium can help in the management of elevated blood pres-)]TJ 0 -1.2 TD [(sure. However)56(, there is no simple statement that can be made, because some patients with polycystic kidney disease)]TJ 0 -1.19999 TD 0.0251 Tw (actually waste sodium. If a diuretic is par)Tj 16.91562 0 TD 0.025 Tw [(t of the blood pressure treatment plan for an individual patient, it mak)19(es sense to)]TJ -16.91562 -1.2 TD [(follow modest sodium restriction \(3000 mg of sodium/day)116(, which is also the RD)38(A for the general population\). However)55(,)]TJ 0.0251 Tw (many patients do not need sodium restriction and, in fact, do better without it. It is best to check with your nephrologist)' 0 -1.19999 TD -0.0149 Tc (or a renal dietitian about your individual requirement.)Tj ET BT /F0 1 Tf 12 0 0 12 72 262.6347 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(My nephr)18(ologist sent me to a nutritionist. I was pr)17(ovided with a r)18(enal diet and instructed)]TJ 0 -1.19999 TD [(to eat 60 gm of pr)18(otein daily)91(. I was also told to r)18(estrict phosphorus, because phosphorus)]TJ 0 -1.2 TD -0.0001 Tc 0.0278 Tw (and calcium levels become out of balance and cause bone disease. Do the r)Tj 35.82307 0 TD -0.0002 Tc (estrictions)Tj -35.82307 -1.2 TD 0 Tc 0.028 Tw [(change as the disease pr)18(ogr)17(esses?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 194.5847 Tm 0 0 0 1 k (Y)Tj 0.43244 0.00001 TD -0.0148 Tc 0.0251 Tw (our nutritionist is cor)Tj 8.74004 0.00001 TD -0.015 Tc 0.025 Tw [(rect in recommending a moderate restriction of phosphor)-18(us early)116(, even when the renal function is)]TJ -9.17248 -1.20001 TD [(only slightly reduced and the level of phosphor)-18(us in the blood is still nor)-18(mal. An abnor)-18(mal accumulation of phosphor)-19(u)1(s)]TJ 0 -1.2 TD [(may result in the deposit of solid par)-18(ticles of calcium phosphate in tissues and damage to a variety of organs, including)]TJ T* [(the kidney)116(. )]TJ 0 -2.39999 TD [(The parathyroid hor)-18(mone (PTH) controls how much phosphor)-18(us is excreted in the urine. If phosphor)-18(us intak)18(e is high,)]TJ 0 -1.2 TD [(the parathyroid glands must secrete increased amounts of the hor)18(mone to k)19(eep the ser)-18(um phosphor)-19(us nor)-18(mal.)]TJ -0.0148 Tc (Unfor)' 2.3939 0 TD -0.0149 Tc (tunately)Tj 3.17953 0.00001 TD -0.015 Tc [(, excess levels of PTH stimulate bone destr)-18(uction. When the renal function has declined to less than 25)]TJ -5.5734 -1.2 TD [(percent of nor)-18(mal, PTH cannot adequately clear the phosphor)18(us, and ser)-18(um phosphor)-18(us rises. So you can see that the)]TJ T* [(process of bone demineralization is a long process that can be delayed by a moderate reduction in dietar)-18(y phosphor)-18(u)-1(s)]TJ 0.0251 Tw (early on. )' ET BT /F0 1 Tf 9 0 0 9 40.4999 36.4268 Tm /CS0 cs 1 scn 0.2778 Tc 0.0278 Tw (32 )Tj 2.8349 0 Td 0.5 scn (Q&A on PKD)Tj /F7 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj ET Q endstream endobj 45 0 obj << /Length 6475 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F10 1 Tf 10 0 0 10 36 712.9834 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(The control of the intestinal absorption of phosphor)-18(us as the renal function declines can be accomplished by restricting)]TJ 0 -1.2 TD 0.0251 Tw (the dietar)Tj 3.98749 0.00001 TD 0.025 Tw [(y phosphor)-18(us and by the use of agents, known as \322phosphate binders,\323 which bind the phosphor)-18(us in the diet)]TJ -3.98749 -1.19999 TD [(and prevent its absorption. Both aluminum and calcium are phosphate binders, which for)-18(m insoluble complexes with)]TJ 0 -1.2 TD [(phosphor)-18(us and limit absorption. Calcium salts are the most commonly used phosphate binders, because aluminum)]TJ 0.0251 Tw (accumulates in renal failure and is toxic to many organs, including the brain and bone. )' ET BT /F0 1 Tf 12 0 0 12 36 627.4338 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(When I was first diagnosed with PKD, I was told not to eat licorice. W)18(ould you please)]TJ 0 -1.2 TD -0.0001 Tc 0.0278 Tw (explain why?)Tj ET BT /F10 1 Tf 10 0 0 10 36 588.1837 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Licorice root in chronic use can cause sodium and water retention. P)42(otassium loss may also occur)56(. These can result in)]TJ 0 -1.19999 TD [(hyper)-18(tension, edema and hypokalemia (a low potassium concentration). In addition to licorice sticks, a number of other)]TJ 0 -1.20001 TD [(products contain considerable amounts of glycyr)-18(rhetinic acid, the active ingredient in licorice. These include cer)-18(tain)]TJ T* [(health products (herbal cough mixture, licorice tea) and chewing gums, chewing tobacco, and cer)-18(tain alcoholic drinks)]TJ 0 -1.2 TD -0.0149 Tc 0.0251 Tw ((Belgium beers and anisette).)Tj ET BT /F0 1 Tf 12 0 0 12 36 502.6341 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(I am a patient with a very mild case of PKD. I have no complications, so far)92(, and the cysts)]TJ 0 -1.19999 TD -0.0002 Tc (wer)Tj 1.66772 0 TD 0 Tc [(e discover)18(ed by accident. W)17(e live in a city with very har)18(d water)92(, and I am considering)]TJ -1.66772 -1.2 TD -0.0001 Tc 0.0278 Tw (installing a water softener in my new house. Will the added sodium in the softened water)Tj T* 0 Tc 0.028 Tw [(have negative long-term ef)18(fects? Is potassium an option to soften the water instead of)]TJ 0 -1.19999 TD -0.0001 Tc (sodium?)Tj ET BT /F10 1 Tf 10 0 0 10 36 420.1841 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (Small amounts of sodium added in the sof)Tj 17.44248 0 TD (tened water probably are safe in your case if)Tj 18.05876 0 TD (, as you have indicated, your poly)Tj 13.73067 0 TD 0 Tc (-)Tj -49.23191 -1.2 TD -0.015 Tc 0.025 Tw [(cystic kidney disease is ver)-18(y mild and your blood pressure is nor)-18(mal. Never)-18(theless, the situation may be different in other)]TJ 0.0251 Tw (patients with PKD. An excellent source of infor)' 19.48622 0 TD (mation related to your question is an ar)Tj 16.28256 0 TD (ticle published in Archives of)Tj -35.76878 -1.20001 TD 0.025 Tw [(Inter)-18(nal Medicine of 1997 (vol. 157, pages 218-222). The following is a summar)-18(y of useful infor)-18(mation mainly derived)]TJ 0 -1.19999 TD [(from that ar)-18(ticle.)]TJ 0 -2.4 TD [(W)79(ater sof)-18(tening is used to remove the \322hardness\323 in the water)56(, which is mainly caused by calcium and magnesium salt.)]TJ 0 -1.19999 TD 0.0251 Tw (The main reasons for \322sof)Tj 10.579 0 TD (tening\323 water are to prevent mineral buildup in pipes and appliances, to improve water taste,)Tj -10.579 -1.2 TD 0.025 Tw [(and prevent iron stains in toilets and sinks. In the sof)-18(tening process, sodium chloride or potassium chloride is exchanged)]TJ 0.0251 Tw (for the undesirable calcium and magnesium, thereby increasing the sodium or potassium content of the water \(sodium)' 0 -1.19999 TD 0.025 Tw [(chloride is more commonly used\). In one study)116(, the sodium content in multiple samples of sof)-18(tened water averaged 278)]TJ 0 -1.2 TD -0.0149 Tc 0.0251 Tw (mg/L. Most of the sodium consumed in the diet derives from the salt used in food processing. While non-sof)Tj 45.16158 0.00001 TD (tened water)Tj -45.16158 -1.20001 TD -0.015 Tc 0.025 Tw [(contains ver)-18(y little sodium, sof)-18(tened water may contain significant amounts. Assuming a daily consumption of 2.5 liters of)]TJ 0 -1.2 TD [(water)56(, the sodium contained in sof)-18(tened water may add up to a significant amount. The recommended total daily intak)19(e)]TJ 0 -1.19999 TD [(of sodium is 2300-3000 mg. Alter)-18(natives to avoid the sof)18(tened water for dietar)-18(y purposes are to bypass the sof)-18(tener for a)]TJ 0 -1.2 TD [(drinking water faucet, installing a reverse osmosis \(RO\) to remove sodium, using potassium chloride \(K)42(Cl\) instead of)]TJ T* [(sodium chloride (NaCl) in the sof)-18(tener or using bottled water for cooking and drinking.)]TJ 0 -2.39999 TD -0.0151 Tc 0.0251 Tw (While the increased intak)Tj 10.39911 -0.00001 TD -0.015 Tc 0.025 Tw [(e of sodium from sof)-18(tened water may be of little impor)-18(tance to healthy individuals, the same)]TJ -10.39911 -1.19999 TD [(may not be tr)-18(ue in patients with hyper)-18(tension, renal or cardiac disease.)]TJ ET BT /F0 1 Tf 12 0 0 12 36 154.635 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (My husband has PKD. He feels fine, and I would like to keep it that way for as long as)Tj 0 -1.2 TD 0 Tc 0.028 Tw [(possible. He eats right and exer)18(cises. I would like him to start taking a multivitamin, but)]TJ T* [(he has been told to stay away fr)18(om vitamin C due to PKD. I\325ve hear)17(d so many good)]TJ -0.0001 Tc 0.0278 Tw (things about vitamin C, as well as other antioxidants. Please advise whether it is true that)' (he should avoid vitamin C.)' ET BT /F10 1 Tf 10 0 0 10 36 72.185 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (A number of studies have suggested that oxidative stress may play a role in the pathogenesis of polycystic kidney disease,)Tj 0 -1.2 TD -0.0149 Tc (but, for now)Tj 4.9695 0 TD -0.015 Tc (, there are no data to suppor)Tj 11.87874 0.00001 TD (t the use of antioxidants in the treatment of human ADPKD. In regard to the use)Tj ET BT /F0 1 Tf 9 0 0 9 461.1341 36.4268 Tm /CS0 cs 0.5 scn 0.2778 Tc 0.0278 Tw (Q&A on PKD)Tj 9.8731 0 Td 1 scn (33)Tj /F7 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj /F7 1 Tf 0.27802 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj ET Q endstream endobj 46 0 obj << /Length 6746 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F10 1 Tf 10 0 0 10 72 712.9834 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (of vitamin C in patients with ADPKD, a number of issues have to be considered. Vitamin C, or ascorbic acid, is essential)Tj 0 -1.2 TD -0.0151 Tc (for many metabolic processes. The recommended daily allowance of ascorbic acid is 60 mg daily)Tj 39.73333 0.00001 TD -0.0149 Tc (. Higher doses of vitamin)Tj -39.73333 -1.19999 TD -0.015 Tc (C have been recommended by some investigators for its antioxidant effect. This is usually safe, but not always.)Tj 0 -2.4 TD 0.025 Tw [(A small fraction of vitamin C is metabolized into oxalate. In addition, oxalate is for)-18(med during the metabolism of cer)18(tain)]TJ 0 -1.19999 TD [(amino acids and is absorbed from cer)-18(tain foods in the diet. The only way the human body can get rid of the oxalate is by)]TJ 0 -1.2 TD 0.0251 Tw (elimination into the urine. Precipitation of calcium oxalate in the urine can cause kidney stones. In addition, when the)Tj (absorption and/or production of oxalate exceeds the renal capacity for excretion into the urine, the oxalate accumulates)' T* 0.025 Tw [(and precipitates in the tissues in the for)-18(m of calcium oxalate salts. This can result in damage to the kidneys and other vital)]TJ 0 -1.19999 TD [(tissues such as the hear)-18(t.)]TJ 0 -2.4 TD [(Concer)-18(ns that high doses of vitamin C could result in the development of kidney stones in other)-18(wise healthy individuals,)]TJ 0 -1.19999 TD 0.0251 Tw (as a result of its metabolism into oxalate, have not been substantiated. The reason why this does not occur is that both)Tj 0 -1.2 TD 0.025 Tw [(the absorption of vitamin C from the gut and its metabolic transfor)18(mation into oxalate are both saturable processes. As)]TJ 0.0251 Tw (the dose of vitamin C is increased, the fraction of the dose that is absorbed and the fraction of absorbed vitamin C that is)' 0 -1.19999 TD 0.025 Tw [(metabolized into oxalate decrease. As a result, even high doses of vitamin C cause only minor increases in the urinar)-18(y)]TJ 0 -1.2 TD 0.0251 Tw (excretion of oxalate in healthy individuals.)Tj 0 -2.39999 TD 0.025 Tw [(High doses of vitamin C should not be used by patients who are stonefor)-18(mers or have renal insufficiency)116(. P)24(atients with)]TJ 0 -1.2 TD [(recur)-18(rent kidney stones are advised to limit their daily vitamin C intak)19(e to 100-200 mg, because subsets of these patients)]TJ T* [(may be more susceptible to increased oxalate production due to metabolic defects. P)24(atients with chronic renal insuffi-)]TJ T* [(ciency should also avoid large doses of vitamin C because deposition of calcium oxalate cr)-18(ystals in the kidneys and other)]TJ 0 -1.19999 TD 0.0251 Tw (tissues occurs commonly in patients with chronic renal failure.)Tj ET BT /F0 1 Tf 12 0 0 12 72 411.4344 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (My nephr)Tj 4.36202 0 TD -0.0002 Tc (ologist told me that major br)Tj 13.19458 0 TD (eakthr)Tj 2.88941 0 TD -0.0001 Tc (oughs in PKD r)Tj 6.9918 0 TD -0.0002 Tc (esear)Tj 2.52051 0 TD -0.0001 Tc (ch have occurr)Tj 6.91006 0 TD (ed in the)Tj -36.86837 -1.20001 TD (last few years. What will it take to go fr)Tj 18.35475 0 TD -0.0002 Tc (om these r)Tj 4.94522 0 TD (esear)Tj 2.52051 0 TD (ch br)Tj 2.38032 0 TD (eakthr)Tj 2.88941 0 TD 0 Tc 0.028 Tw [(oughs to new ef)18(fective)]TJ -31.09021 -1.20001 TD -0.0001 Tc (therapies?)Tj ET BT /F10 1 Tf 10 0 0 10 72 357.7843 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(This is a ver)-18(y impor)-18(tant question. Although scientific breakthroughs come along, translating these findings into patient)]TJ 0 -1.2 TD [(care or curative therapy can of)-18(ten tak)18(e a long time. The most exciting scientific breakthroughs in PKD research are)]TJ 0 -1.19999 TD -0.0149 Tc 0.0251 Tw (related to the identification, location and understanding of the PKD and ARPKD genes. This is the first step in getting)Tj 0 -1.2 TD -0.015 Tc (closer to a cure for these diseases. W)Tj 15.40769 0 TD -0.0149 Tc (ith this infor)Tj 5.06634 0 TD (mation, investigators are now beginning to understand how these genes)Tj -20.47403 -1.20001 TD -0.015 Tc (and other related genes work within and between cells. This infor)Tj 27.3216 0 TD 0.025 Tw [(mation will then be translated to deter)-18(mine how to)]TJ -27.3216 -1.19999 TD [(manipulate PKD and ARPKD gene function to either bypass an ineffectual gene product, over)-18(ride a mutated gene product)]TJ 0 -1.2 TD [(or some sor)-18(t of combination of the two. Biophar)-18(maceutical research is involved in identif)-18(ying or creating compounds)]TJ 0.0251 Tw (that could potentially provide the function that a mutated ADPKD or ARPKD gene cannot. These compounds will need to)' 0 -1.19999 TD (go through extensive testing in the test tube, then in experimental animal models and finally in humans prior to being)Tj 0 -1.2 TD (available for clinical use by practicing physicians and health care providers. The magnitude of this process is obvious. )Tj ET BT /F0 1 Tf 12 0 0 12 72 212.2349 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(I have just been diagnosed with br)18(east cancer)91(, and must take cytoxan, methotr)18(exate, and)]TJ 0 -1.2 TD -0.0001 Tc (5-fluor)Tj 3.00147 0 TD 0 Tc [(ouracil. What ef)18(fect on my polycystic kidneys should I expect? What should be)]TJ -3.00147 -1.20001 TD 0 Tw [(monitor)18(ed?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 158.5847 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(The medications that you are about to tak)19(e for breast cancer have many toxicities, including hair)56(, liver)55(, skin, bone mar)18(row)112(,)]TJ 0 -1.2 TD 0.0251 Tw (brain and kidney)Tj 6.79353 0.00001 TD (. Only the cytoxan is directly toxic to the urinar)Tj 19.59425 0.00001 TD (y system and can result in bleeding from the bladder)Tj 21.59974 0.00001 TD 0 Tc (.)Tj -47.98752 -1.20001 TD -0.015 Tc 0.025 Tw [(This bleeding is called hemor)-18(rhagic cystitis. This condition can be avoided by assuring excellent hydration prior to being)]TJ 0 -1.2 TD [(given the cytoxan. The kidney is an impor)-18(tant ter)-18(minal eliminator of many dr)-18(ugs. Therefore, if there is a decrease in)]TJ 0.0251 Tw (kidney function below nor)' 10.91327 0.00001 TD (mal, it is ver)Tj 4.96424 0.00001 TD 0.025 Tw [(y impor)-18(tant that your oncologist or physician dose your medications appropriately)]TJ -15.8775 -1.2 TD [(to avoid toxicity to other organs in the body)116(. )]TJ ET BT /F0 1 Tf 9 0 0 9 40.4999 36.4268 Tm /CS0 cs 1 scn 0.2778 Tc 0.0278 Tw (34 )Tj 2.8349 0 Td 0.5 scn (Q&A on PKD)Tj /F7 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj ET Q endstream endobj 47 0 obj << /Length 6395 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 12 0 0 12 36 711.4336 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (What has happened to the drug taxol?)Tj ET BT /F10 1 Tf 10 0 0 10 36 686.5835 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(T)135(axol is a chemotherapeutic medication that functions by changing how cells maintain their inter)-18(nal sk)18(eleton or infrastr)-18(uc)]TJ 0 -1.2 TD [(ture. T)134(axol showed tremendous promise in a mouse model of polycystic kidney disease, with a reduction in cyst size,)]TJ 0.0251 Tw (kidney size and prolongation of life. However)' 18.90873 0.00001 TD 0.025 Tw [(, when the dr)-18(ug was tested fur)-18(ther in other animal models, no benefit was)]TJ -18.90873 -1.2 TD [(found. As well, the toxicities of the dr)-18(ug were common and made this agent less ideal for chronic therapy in PKD patients)]TJ T* [(who are other)-18(wise healthy)116(. However)55(, understanding the effects of taxol has helped investigators tr)-17(y similar directions for)]TJ T* [(therapy in PKD and has been ver)-18(y helpful in understanding the pathogenesis of disease. )]TJ ET BT /F0 1 Tf 12 0 0 12 36 589.0339 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(I have polycystic kidney disease. My serum cr)18(eatinine is 4.3 mg/dL. Because of a history)]TJ 0 -1.2 TD [(of chest pain and the r)18(esults of noninvasive studies, my doctor r)17(ecommends that I have a)]TJ 0 -1.19999 TD [(cor)18(onary angiogram and possible angioplasty)91(. I have been told that the contrast agent)]TJ 0 -1.2 TD [(needed for this study may damage my kidneys. Is ther)18(e an ef)17(fective substitute for the)]TJ 0 -1.19999 TD -0.0001 Tc 0.0278 Tw (contrast material?)Tj ET BT /F10 1 Tf 10 0 0 10 36 506.5839 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(This is an impor)-18(tant question. The contrast that is used to per)18(for)-18(m a coronar)-18(y angiogram includes iodinated contrast.)]TJ 0 -1.19999 TD [(This contrast agent is filtered by the kidneys and is toxic to the tubules in the kidney)117(. P)23(atients with poor renal function)]TJ 0 -1.20001 TD [(are par)-18(ticularly at risk for renal toxicity af)-18(ter receiving iodinated contrast because more contrast comes into the remaining)]TJ 0 -1.2 TD -0.0149 Tc 0.0251 Tw (nephrons. However)Tj 8.39231 0 TD -0.015 Tc (, there are times when patients with renal insufficiency need to have a contrast study per)Tj 36.49769 0 TD 0 Tw [(for)-18(med.)]TJ -44.89 -1.2 TD 0.025 Tw [(There are many ways to minimize the risk of toxicity to the kidney af)18(ter receiving a contrast agent. F)19(irst, the physician)]TJ 0 -1.19999 TD [(per)-18(for)-18(ming the test (usually the cardiologist) needs to know that the patient has renal insufficiency so that she/he can)]TJ 0 -1.2 TD 0.0251 Tw (limit the amount of contrast that you receive. Next, the nephrologist needs to be involved prior to the procedure.)Tj (Usually when patients are given intravenous fluids and medications that could contribute to the toxicity of the contrast)' 0 -1.19999 TD (\(non-steroidal anti-inflammator)Tj 12.86131 0 TD (y agents and diuretics\) are stopped for 3-4 days prior to the procedure, the chance of)Tj -12.86131 -1.2 TD (kidney damage occur)Tj 8.83354 0 TD -0.0148 Tc (ring is ver)Tj 4.05319 0 TD -0.0152 Tc (y small. )Tj -12.88673 -2.4 TD -0.015 Tc (A recent study has demonstrated that a medication called mucomyst \(acetyl cystein\) given for 3 days \(beginning one day)Tj 0 -1.2 TD 0.025 Tw [(prior to the administration of contrast\) is protective against kidney toxicity from contrast. Y)117(our nephrologist and cardiolo-)]TJ 0.0251 Tw (gist can decide whether this medication would be beneficial in your case. )' 0 -2.39999 TD 0.025 Tw [(There are ways to obtain the infor)-18(mation needed that the contrast study would provide by using other agents. This)]TJ 0 -1.2 TD [(includes doing a CO angiogram with carbon monoxide. This is more difficult for the cardiologist to per)-18(for)-18(m, and the)]TJ T* [(images are not clear; however)56(, it can be done. Alter)18(natively)116(, there have been other radio-opaque agents developed that)]TJ 0 -1.19999 TD [(have been preliminarily repor)-18(ted not to be toxic to the kidneys that could be used; however)56(, they are ver)-18(y expensive and)]TJ 0 -1.2 TD 0.0251 Tw (have not always shown improvement in the occur)Tj 20.54179 0.00001 TD (rence of damage to the kidneys af)Tj 13.96619 0.00001 TD -0.0149 Tc (ter a contrast study)Tj 7.774 0.00001 TD -0.0151 Tc (. )Tj ET BT /F0 1 Tf 12 0 0 12 36 241.0348 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (At age 45, my PKD kidneys failed. I understand that this is a little early)Tj 32.8843 0 TD (. I\325ve never had)Tj -32.8843 -1.2 TD 0 Tc 0.028 Tw [(childr)18(en, don\325)17(t eat junk food or drink cof)18(fee or tea. I was even a vegetarian for two years.)]TJ 0 -1.19999 TD -0.0001 Tc 0.0278 Tw (My sin is chocolate. Did chocolate do me in?)Tj ET BT /F10 1 Tf 10 0 0 10 36 187.3847 Tm 0 0 0 1 k -0.0151 Tc 0.0251 Tw (LONG LIVE CHOCOL)Tj 8.92268 0.00001 TD 0 Tc (A)Tj 0.49397 0.00001 TD -0.015 Tc (TE!!! The chocolate that you have been enjoying did nothing to damage your kidneys. The)Tj -9.41665 -1.2 TD (average age of entr)Tj 7.83276 0.00001 TD (y into dialysis in ADPKD is 52-57 years of age, but the range is broad. ADPKD patients have occasionally)Tj -7.83276 -1.20001 TD (begun dialysis in their 20s and some individuals live into their 80s or 90s without requiring dialysis at all. Although you are)Tj 0 -1.2 TD -0.0149 Tc (young with regard to star)Tj 10.39784 0.00001 TD -0.015 Tc (ting dialysis, 45 years of age is not uncommon in ADPKD. This broad range of age is seen within)Tj -10.39784 -1.2 TD -0.0151 Tc (families as well as between families with ADPKD. Why the broad spectr)Tj 29.4024 0.00001 TD -0.0149 Tc (um for age of initiating dialysis exists is hard to)Tj -29.4024 -1.20001 TD -0.015 Tc 0.025 Tw [(explain but may in par)-18(t be related to the fact that mutations in the PKD genes also occur in the good copy of the gene in)]TJ T* [(the cells that line cysts in the kidney)116(. )]TJ ET BT /F0 1 Tf 9 0 0 9 461.1341 36.4268 Tm /CS0 cs 0.5 scn 0.2778 Tc 0.0278 Tw (Q&A on PKD)Tj 9.8731 0 Td 1 scn (35)Tj /F6 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj ET Q endstream endobj 48 0 obj << /Length 6722 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 12 0 0 12 72 711.4336 Tm /CS0 cs 1 scn 0.028 Tw [(My husband\325)74(s sister had general surgery on her polycystic kidneys four years ago to drain)]TJ 0 -1.2 TD [(some cysts. Now the cysts ar)18(e back, and she is contemplating the same surgical pr)17(oce-)]TJ 0 -1.19999 TD [(dur)18(e. Can you pr)17(ovide some information on this surgical pr)18(ocedur)18(e?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 657.7835 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (There are a number of different surgical techniques that are available for patients who have enlarged painful cysts either in)Tj 0 -1.19999 TD 0.025 Tw [(the kidney or the liver)56(. The least invasive way to drain cysts is to use a needle, place it in the cyst, and withdraw fluid.)]TJ 0 -1.2 TD [(This requires a local anesthetic and no incision. This procedure is usually done by an inter)-18(ventional radiologist. This)]TJ T* [(procedure is limited to a few cysts that should locally be causing symptoms. Usually patients have more diffuse pain prob)1(-)]TJ 0 -1.19999 TD [(lems, including bilateral flank pain or abdominal pain. T)167(wo surgical approaches are cur)-18(rently available. One is a)]TJ 0 -1.2 TD [(laparoscopic approach in which the surgeon mak)19(es two small incisions and can see the kidney and cysts through a)]TJ 0 -1.20001 TD [(camera and selectively drain the cysts. The other approach is open surger)-18(y)116(, in which an incision is made and the cysts)]TJ 0 -1.19999 TD 0.0251 Tw (drained. The laparoscopic approach is different, from the open surgical approach in that fewer cysts can be drained.)Tj 0 -1.2 TD 0.025 Tw [(However)56(, the operating time is shor)-18(ter)56(, and recover)-19(y time is much quick)19(er)56(. In both approaches, the cysts are destroyed)]TJ T* [(per)-18(manently)116(. However)56(, new cysts typically for)-18(m and replace the previous cysts. Usually the majority of individuals gain)]TJ T* [(much in the way of pain relief with both of these procedures. The pain disappears per)-18(manently or for approximately two)]TJ 0 -1.19999 TD [(years. A minority of patients (approximately 30%) develop recur)18(rence of symptoms. When these individuals undergo cyst)]TJ 0 -1.20001 TD 0.0251 Tw (reduction procedures a second time, pain disappears or improves in the majority of patients. The surgical approaches)Tj 0 -1.2 TD 0.025 Tw [(become more difficult because of the scar tissue. This means that more of)-18(ten a laparoscopic approach may not be)]TJ 0 -1.19999 TD 0.0251 Tw (successful, and open procedures may need to be used.)Tj ET BT /F0 1 Tf 12 0 0 12 72 452.2343 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(I have ADPKD and want to know if ther)18(e is a safe weight gainer \(or pr)17(otein\) I could take)]TJ 0 -1.2 TD [(for weight training, to gain mor)18(e muscle and body mass?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 412.9842 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (There are few additives that should be tak)Tj 17.26293 0 TD (en by individuals with renal diseases that do not either affect the kidney or)Tj -17.26293 -1.2 TD -0.0157 Tc (mak)Tj 1.74606 0 TD -0.015 Tc (e it difficult to interpret measures of renal function. Creatine is an additive tak)Tj 32.18798 0 TD 0.025 Tw (en to increase muscle stores in individ-)Tj -33.93404 -1.20001 TD -0.0151 Tc 0.0251 Tw (uals who weight lif)Tj 7.69946 0 TD -0.015 Tc (t. This substance, however)Tj 11.11576 0 TD -0.0149 Tc (, inter)Tj 2.4382 0 TD -0.015 Tc (feres with the blood tests that are done to measure ser)Tj 22.5838 0 TD -0.0149 Tc (um creatinine)Tj -43.83722 -1.2 TD -0.015 Tc (concentrations in the bloodstream. This mak)Tj 18.71601 0 TD 0.025 Tw [(es it difficult to deter)-18(mine renal function accurately in an individual. Other)]TJ -18.71601 -1.2 TD [(additives typically tak)19(en include stimulants to muscle growth or hor)-18(mones. These compounds can be dangerous to other)]TJ -0.0149 Tc 0.0251 Tw (organ systems in the body)' 10.68495 0 TD -0.015 Tc (, including the liver)Tj 7.871 0 TD (, and may have cyst-growth-promoting effects as well. Any additive or over)Tj 30.69914 0 TD 0 Tc (-)Tj -49.25509 -1.20001 TD -0.015 Tc 0.025 Tw [(the-counter medicine should be reviewed with your physician before embarking on long-ter)-18(m intak)19(e. )]TJ ET BT /F0 1 Tf 12 0 0 12 72 303.4346 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (What is the pr)Tj 6.49058 0 TD 0 Tc 0.028 Tw [(oper type of exer)18(cise that an ADPKD patient can do?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 278.5845 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (Exercise is an impor)Tj 8.28523 0.00001 TD (tant health benefit that all ADPKD patients should under)Tj 23.28757 0.00001 TD -0.0154 Tc (tak)Tj 1.22751 0.00001 TD -0.015 Tc (e. However there are some exercises that)Tj -32.80031 -1.20002 TD (put an ADPKD individual at increased health risk. These include contact spor)Tj 31.95466 0.00001 TD -0.0151 Tc (ts, in which the kidney may be hit or)Tj -31.95466 -1.19999 TD -0.015 Tc 0.025 Tw [(knock)18(ed. A good example of this is karate, football, or boxing. As well, there are exercises that have repetitive jar)-17(ring or)]TJ 0 -1.2 TD 0.0251 Tw (impact. A good example of this is horseback riding. Although there is no evidence that these exercises will result in worse)Tj (renal function, there are many anecdotal repor)' 19.26205 0.00001 TD -0.0149 Tc (ts of blood in the urine appearing in young individuals af)Tj 23.36282 0.00001 TD -0.015 Tc (ter being hit in the)Tj -42.62487 -1.2 TD 0.025 Tw [(kidneys or af)-18(ter an other)-18(wise uneventful horseback ride. Given that blood in the urine appears to be a risk factor for)]TJ T* [(progression to renal failure in ADPKD, if other spor)-18(ting activities are of interest, they should be considered as an alter)-18(na)]TJ 0.0251 Tw (tive source of exercise. )' 0 -2.39999 TD 0.025 Tw [(Always, regardless of the exercise chosen, hydration is an impor)18(tant component to the exercises per)-18(for)-18(med by ADPKD)]TJ 0 -1.2 TD 0.0251 Tw (individuals. There is a mild concentrating defect present in the kidneys of individuals with ADPKD that will exacerbate)Tj (dehydration if fluids are not available on a regular basis. The concentration defect becomes more severe as renal function)' 0 -1.19999 TD 0.025 Tw [(declines. Therefore, it is impor)-18(tant to mak)19(e sure that fluids are available during all exercise programs.)]TJ ET BT /F0 1 Tf 9 0 0 9 40.4999 36.4268 Tm /CS0 cs 1 scn 0.2778 Tc 0.0278 Tw (36 )Tj 2.8349 0 Td 0.5 scn (Q&A on PKD)Tj /F6 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj ET Q endstream endobj 49 0 obj << /Length 6932 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 12 0 0 12 36 711.4336 Tm /CS0 cs 1 scn 0.028 Tw [(What is the pr)18(oper diet for a patient with ADPKD to pr)17(event the pr)18(ogr)17(ession to end-stage)]TJ 0 -1.2 TD [(r)18(enal failur)18(e?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 672.1835 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(One of the simplest dietar)-18(y changes to mak)19(e that can help reduce loss of function in ADPKD is to reduce sodium intak)19(e.)]TJ 0 -1.2 TD [(Dietar)-18(y protein restriction has demonstrated a significant impact on cystic disease in rodent models of cystic disease.)]TJ 0 -1.19999 TD -0.0149 Tc 0.0251 Tw (Lowering protein intak)Tj 9.36672 0.00001 TD -0.015 Tc (e will reduce cyst burden by more than 20% in most animal models. The benefits of protein)Tj -9.36672 -1.20001 TD 0.025 Tw [(restriction are improved even more when the type of protein intak)19(e is controlled. F)42(or example, soy)19(-based protein intak)18(e)]TJ T* [(in animal models reduces cyst burden compared to casein-based protein diets. In humans, reduced protein intak)19(e in)]TJ 0 -1.19999 TD 0.0251 Tw (ADPKD has not been demonstrated to be beneficial in slowing progression to renal failure. Studies in human ADPKD)Tj 0 -1.2 TD 0.025 Tw [(have only been done in advanced disease, i.e., those with less than 50% nor)-18(mal renal function, with massive cystic involve-)]TJ T* [(ment. Does this mean that it is not wor)-18(th restricting protein in ADPKD in individuals with renal insufficiency? No. Protein)]TJ 0 -1.19999 TD [(restriction in all individuals with renal insufficiency)116(, whether they have ADPKD or not, is beneficial in reducing the symp)1(-)]TJ 0 -1.20001 TD [(toms of uremia. Reducing protein intak)19(e to between 0.6 and 0.8 gm/kg/day will allow for adequate protein intak)19(e and)]TJ T* [(minimize the production of uremic toxins that the kidney is ultimately going to excrete from the body)117(. Reducing protein)]TJ 0 -1.2 TD [(intak)19(e also reduces the amount of acid and phosphor)-18(us that is tak)18(en in and will help reduce the acidosis and hyper)1(-)]TJ 0 -1.19999 TD [(parathyroidism that occurs in chronic renal insufficiency)116(. )]TJ ET BT /F0 1 Tf 12 0 0 12 36 490.6342 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(What is the r)18(elationship between a primary car)17(e physician and a nephr)18(ologist?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 465.784 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (The relationship between a primar)Tj 14.25828 0 TD (y care physician and a nephrologist is a ver)Tj 17.6124 0 TD 0.025 Tw [(y impor)-18(tant one. Clearly all relationships)]TJ -31.87068 -1.2 TD [(depend on the individuals involved. Of)-18(ten the primar)-18(y care physician for renal patients is a nephrologist. The nephrolo-)]TJ -0.0148 Tc 0.0251 Tw (gist is impor)' 5.08531 0 TD -0.0149 Tc (tant in providing treatment for anemia, acidosis, dietar)Tj 22.38357 0 TD (y protein restriction, blood pressure control and to)Tj -27.46888 -1.20001 TD -0.015 Tc 0.025 Tw [(counsel the patient in preparation for dialysis. These are all conditions that require continued, long-ter)-18(m follow-up. The)]TJ 0 -1.19999 TD 0.0251 Tw (patients with ADPKD who are in the early stages of their disease need a primar)Tj 32.4124 0 TD (y care doctor to continuously monitor)Tj -32.4124 -1.2 TD (them with regard to their renal function, blood pressure control and level of proteinuria. The patient needs to have a)Tj T* 0.025 Tw [(consistent and direct physician relationship with both physicians. Both physicians play impor)-18(tant roles in different stages)]TJ 0.0251 Tw (of the renal disease process. In addition, it is expected and hoped for that the nephrologist and primar)' 42.25299 0 TD -0.0151 Tc (y care doctor work)Tj -42.25299 -1.19999 TD -0.015 Tc 0.025 Tw [(well together)56(.)]TJ ET BT /F0 1 Tf 12 0 0 12 36 332.2346 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (How often should a patient with PKD visit a nephr)Tj 23.13996 0 TD (ologist? How often should the cr)Tj 15.42818 0 TD (eati)Tj 1.68555 0 TD 0 Tc (-)Tj -40.25369 -1.20001 TD -0.0001 Tc (nine level be checked?)Tj ET BT /F10 1 Tf 10 0 0 10 36 292.9845 Tm 0 0 0 1 k -0.0151 Tc 0.0251 Tw (ADPKD patients should have a check-up with a physician no less than once a year)Tj 33.55505 0.00001 TD -0.015 Tc (. This will guarantee at least an annual)Tj -33.55505 -1.20001 TD (check on blood pressure and screening for the presence of proteinuria by urine dipstick. Ser)Tj 38.41367 0.00001 TD (um creatinine concentra)Tj 10.05307 0.00001 TD 0 Tc (-)Tj -48.46674 -1.20001 TD -0.015 Tc 0.025 Tw [(tions should be check)19(ed at each of these visits as well. This is the minimum that a patient with polycystic kidney disease)]TJ 0 -1.19999 TD [(should do with regard to regular follow-up. This includes individuals with nor)-18(mal renal function and those with more)]TJ 0 -1.2 TD [(advanced disease. If other conditions such as hyper)-18(tension or abnor)-18(mal renal function are also present, then it is impor-)]TJ T* [(tant to be seen more than once a year)56(. F)42(or all patients with hyper)-18(tension, it is wor)-18(th obtaining a home blood pressure)]TJ 0 -1.19999 TD [(monitoring device so that blood pressures can be check)19(ed at regular inter)-18(vals. Individuals with renal function that is less)]TJ 0 -1.2 TD [(than nor)-18(mal (clearance < 70 ml/min) most lik)19(ely should be seen at least twice a year to include a review of their dietar)-18(y)]TJ T* [(intak)19(e as well as an assessment of their adherence to a diet and their creatinine level. )]TJ ET BT /F0 1 Tf 12 0 0 12 36 159.435 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(What medications ar)18(e damaging to kidneys?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 134.5849 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(There are cer)-18(tain over)37(-the-counter medications that need to be avoided in individuals with renal disease. These include)]TJ 0 -1.2 TD [(the non-steroidal anti-inflammator)-18(y medications such as indomethacin, naprosyn and clinoril. These medications reduce)]TJ -0.0151 Tc 0.0251 Tw (the amount of blood flow to the kidneys, which may be impor)' 25.65581 0.00001 TD -0.015 Tc (tant in ADPKD patients. Other medications such as T)Tj 21.89442 0.00001 TD -0.0151 Tc (ylenol)Tj -47.5502 -1.2 TD -0.015 Tc 0.025 Tw [(or Ultram (by prescription only) can be used for pain control instead. There are newer classes of anti-inflammator)-18(y agents,)]TJ T* [(the CO)23(X)74(-2 inhibitors, such as Celebrex, that may also potentially diminish blood flow to the kidneys and should be)]TJ ET BT /F0 1 Tf 9 0 0 9 461.1341 36.4268 Tm /CS0 cs 0.5 scn 0.2778 Tc 0.0278 Tw (Q&A on PKD)Tj 9.8731 0 Td 1 scn (37)Tj /F6 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj ET Q endstream endobj 50 0 obj << /Length 6269 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F10 1 Tf 10 0 0 10 72 712.9834 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(avoided in ADPKD patients. Sometimes either non-steroidals or the CO)24(X inhibitors are the most effective pain-reducing)]TJ 0 -1.2 TD 0.0251 Tw (agent. In that situation, with limited intak)Tj 17.2319 0.00001 TD 0.025 Tw [(e and super)-18(vision, they can be used with patients. These patients should be)]TJ -17.2319 -1.19999 TD [(encouraged to increase their liquid intak)19(e. )]TJ 0 -2.4 TD [(Other medications that are impor)-18(tant and prescribed by doctors can have potential deleterious effects on kidney function.)]TJ 0 -1.19999 TD 0.0251 Tw (Iodinated contrast, used in computed tomographic scans, is potentially damaging to the kidneys. Also, Bactrim, a helpful)Tj 0 -1.2 TD 0.025 Tw [(d)-1(r)-19(ug for urinar)-18(y tract infections, will selectively increase ser)-18(um creatinine concentrations temporarily without changing)]TJ T* [(the kidney disease itself)37(. This mak)19(es it difficult to deter)18(mine what a patient\325s renal function really is and has to be tak)19(en)]TJ 0 -1.20001 TD -0.0149 Tc 0.0251 Tw (into consideration when assessing someone\325s level of renal function. )Tj ET BT /F0 1 Tf 12 0 0 12 72 579.4338 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(In view of the finding fr)18(om the MDRD study that a low-pr)17(otein diet does not slow the)]TJ 0 -1.19999 TD [(pr)17(ogr)18(ession of PKD, ar)18(e these diets still r)17(ecommended for individuals who have not)]TJ 0 -1.2 TD [(r)18(eached the dialysis stage of the disease?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 525.7839 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(While the low-protein diet study has failed to show clear benefit, dietar)-18(y management can still be recommended to reduce)]TJ 0 -1.20001 TD [(symptoms in patients approaching end-stage renal disease, or in managing potassium and phosphate retention. F)42(or the)]TJ 0 -1.2 TD [(purpose of slowing the progression of renal disease, cer)-18(tain individuals do seem to have a beneficial change in their rate)]TJ 0 -1.19999 TD 0.0251 Tw (of decline, although the overall study is negative. The best course of action is to work with your individual nephrologist)Tj 0 -1.2 TD (and dietician to find out what might be reasonable for you while still maintaining good nutritional status. )Tj ET BT /F0 1 Tf 12 0 0 12 72 440.2343 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (Do we know what causes kidney cysts to enlarge, and ar)Tj 26.44948 0 TD -0.0002 Tc (e ther)Tj 2.65815 0 TD -0.0001 Tc (e any dietary or lifestyle)Tj -29.10763 -1.20001 TD 0 Tc 0.028 Tw [(modifications that can be made to pr)18(event this fr)17(om occurring?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 400.9842 Tm 0 0 0 1 k (W)Tj 0.75325 0 TD -0.015 Tc 0.0251 Tw (e know that, for cysts to enlarge, they need to mak)Tj 20.88672 0 TD (e more cells and secrete more fluid into the inside of the cyst.)Tj -21.63997 -1.20001 TD (Although we know some of the factors that can cause this in a \322test tube,\323 we do not know what causes this in people.)Tj 0 -1.19999 TD (Because a dr)Tj 5.25321 0 TD 0.025 Tw [(ug lik)19(e caffeine can cause cysts to grow in a \322test tube,\323 it may be advisable to avoid large amounts of food)]TJ -5.25321 -1.2 TD 0.0251 Tw (and beverages high in caffeine. )Tj 0 -2.4 TD (My friend with PKD has been told to reduce the amount of protein in her diet, but she also has hypoglycemia \(low blood)Tj 0 -1.19999 TD (sugar\), which is treated by increasing dietar)Tj 17.89064 0 TD (y protein. Which condition should tak)Tj 15.86865 0 TD -0.0149 Tc (e priority in respect to dietar)Tj 11.81523 0 TD (y protein?)Tj -45.57452 -1.20001 TD -0.015 Tc (Protein restriction has been used in an attempt to prolong the course of patients with established chronic kidney disease,)Tj 0 -1.2 TD (including PKD. While the low-protein diet study has failed to show clear benefit, dietar)Tj 35.80577 0 TD 0.025 Tw (y management can still be recom-)Tj -35.80577 -1.19999 TD -0.0149 Tc 0.0251 Tw (mended to reduce symptoms in patients approaching end-stage renal disease. )Tj 0 -2.4 TD -0.015 Tc 0.025 Tw [(Hypoglycemia is ver)-18(y rarely due to organic causes, but a skilled renal dietician could give the best advice about the exact)]TJ 0 -1.19999 TD [(propor)-18(tion of protein and carbohydrate, which must be in any individual\325s diet so that such coexisting conditions can be)]TJ 0 -1.2 TD -0.0151 Tc 0.0251 Tw (accommodated. )Tj ET BT /F0 1 Tf 12 0 0 12 72 207.4348 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(It is my understanding that ther)18(e is a drug in the experimental stage for use on patients)]TJ 0 -1.2 TD -0.0001 Tc 0.0278 Tw (with polycystic kidney disease. I also understand that its use on some animals has)Tj 0 -1.19999 TD -0.0003 Tc (pr)Tj 0.94482 0 TD -0.0001 Tc (oven to eliminate the cysts in those af)Tj 17.62345 0 TD (fected with the disease, but that the amount of)Tj -18.56828 -1.20001 TD 0 Tc 0.028 Tw [(the drug needed to do this is far too gr)18(eat for any human to tolerate. What can you tell us)]TJ 0 -1.2 TD -0.0002 Tc 0.0278 Tw (about this type of r)Tj 8.81524 0 TD (esear)Tj 2.52051 0 TD -0.0001 Tc (ch?)Tj ET BT /F10 1 Tf 10 0 0 10 72 124.9849 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Research is being conducted to find dr)-18(ugs that will slow the progression of renal cysts in patients with polycystic kidney)]TJ 0 -1.2 TD 0.0251 Tw (disease. This kind of research is done in a multistep process. The first step in the sequence is to use test tube models of)Tj -0.0149 Tc (cysts to screen potential dr)' 11.0941 0.00001 TD -0.015 Tc (ugs for the effect of slowing the growth of the cysts. Several candidate dr)Tj 30.20425 0.00001 TD -0.0149 Tc (ugs have been found)Tj -41.2983 -1.2 TD -0.015 Tc (in the test tube experiments to have an effect of slowing the rate at which cysts grow)Tj 34.74589 0.00001 TD (. Some of these are being tested in)Tj ET BT /F0 1 Tf 9 0 0 9 40.4999 36.4268 Tm /CS0 cs 1 scn 0.2778 Tc 0.0278 Tw (38 )Tj 2.8349 0 Td 0.5 scn (Q&A on PKD)Tj /F7 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj /F7 1 Tf 0.27802 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj ET Q endstream endobj 51 0 obj << /Length 6048 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F10 1 Tf 10 0 0 10 36 712.9834 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(experimental animals, but there are no results to repor)-18(t. These types of studies of)-18(ten tak)19(e several years to clearly validate)]TJ 0 -1.2 TD -0.0151 Tc 0.0251 Tw (whether a dr)Tj 5.30374 0.00001 TD -0.015 Tc 0.025 Tw [(ug may be wor)-18(thwhile. When one or more candidate dr)-18(ugs are found, they will be tested in individuals with)]TJ -5.30374 -1.19999 TD 0.0251 Tw (polycystic kidney disease in a strict research protocol, and they will not be offered to the general public for treatment until)Tj 0 -1.2 TD 0.025 Tw [(efficacy and safety have been clearly established. In summar)18(y)116(, there are cur)-18(rently agents in the \322pipeline\323 that are prom-)]TJ T* [(ising, but the use of these dr)-18(ugs in human beings is several years in the future. )]TJ ET BT /F0 1 Tf 12 0 0 12 36 627.4338 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (I have arthritis in my thumb joints, and my doctor advises me to take only acetaminophen.)Tj 0 -1.2 TD (Will aspirin hurt my polycystic kidneys?)Tj ET BT /F10 1 Tf 10 0 0 10 36 588.1837 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Acetaminophen or aspirin in usual doses for shor)-18(t-ter)-18(m indications has no major impact on kidney function. Long-ter)-18(m)]TJ 0 -1.19999 TD [(use of combination analgesics can produce kidney damage, which would be in addition to that already present in poly)1(-)]TJ 0 -1.20001 TD 0.0251 Tw (cystic kidney disease. The best advice is to limit the amount of analgesic that is used. If the need is prolonged, these)Tj 0 -1.2 TD 0.025 Tw [(d)-1(r)-19(ugs should be prescribed under the direct super)-17(vision of a physician who can carefully monitor the patient for adverse)]TJ 0.0251 Tw (effects and who can maintain excellent blood pressure control. )' ET BT /F0 1 Tf 12 0 0 12 36 502.6341 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(Is ther)18(e any known ef)17(fect of lead exposur)18(e on a person with PKD, such as earlier onset or)]TJ 0 -1.19999 TD -0.0003 Tc (mor)Tj 1.79663 0 TD 0 Tc [(e sever)18(e illness?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 463.384 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Lead exposure, par)-18(ticularly in childhood, can lead to kidney disease in the absence of polycystic disease. If a patient has)]TJ 0 -1.19999 TD [(underlying abnor)-18(malities, obviously any lead-induced kidney damage would be additive. There are ways to test whether a)]TJ 0 -1.2 TD [(patient\325s total body lead burden is increased. If this is proven to be the case, it might mak)19(e sense to use chelating dr)-18(u)-1(g)1(s)]TJ T* [(to lower the lead content of the body)116(. The possibility of lead exposure should be evaluated by a competent specialist in)]TJ 0 -1.19999 TD 0.0251 Tw (nephrology or occupational medicine. )Tj ET BT /F0 1 Tf 12 0 0 12 36 377.8344 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(I\325ve hear)18(d that with lapar)17(oscopy)92(, a technique that enables surgeons to operate on inter)-18(nal)]TJ 0 -1.19999 TD [(organs thr)18(ough tiny incisions, kidneys can be r)17(emoved. How does that af)18(fect the viability)]TJ 0 -1.2 TD [(of the tissue for r)18(esear)17(ch? Is ther)18(e any r)18(oom for the use of this technique in the manage)-1(-)]TJ 0 -1.19999 TD -0.0001 Tc 0.0278 Tw (ment of PKD?)Tj ET BT /F10 1 Tf 10 0 0 10 36 309.7844 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (Laparoscopy has been used on an experimental basis in the management of polycystic kidney disease. Under a grant from)Tj 0 -1.19999 TD 0.025 Tw [(the P)42(olycystic Kidney Research F)42(oundation, investigators at Oregon Health Sciences University are reducing the volume of)]TJ 0 -1.2 TD [(cyst fluid through the laparoscope in patients with refractor)-18(y pain and discomfor)-18(t from their polycystic kidneys. Should)]TJ 0.0251 Tw (this technique prove feasible and safe, wider indications for active inter)' 29.21016 0.00001 TD (vention in established cystic disease could be)Tj -29.21016 -1.19999 TD 0.025 Tw [(possible. It would be difficult to completely remove large polycystic kidneys through a laparoscope. F)42(or this, standard)]TJ 0 -1.2 TD [(surgical techniques are probably necessar)-18(y)116(.)]TJ ET BT /F0 1 Tf 12 0 0 12 36 212.2349 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (I am 36-years-old, and I have very painful polycystic kidneys. Doctors say the kidney)Tj 0 -1.2 TD (function is normal. I have a stone in one kidney)Tj 22.13405 0 TD 0 Tc 0.028 Tw [(. I feel constantly tir)18(ed and ill. A surgeon)]TJ -22.13405 -1.20001 TD [(r)18(emoved some of the larger cysts, but that did not help. Now he is considering cutting)]TJ 0 -1.19999 TD -0.0001 Tc 0.0278 Tw (the sympathetic nerves to the kidneys. Can you tell me if this is normal for PKD patients)Tj 0 -1.2 TD (and if ther)Tj 4.70449 0 TD (e is anything else that can be done?)Tj ET BT /F10 1 Tf 10 0 0 10 36 129.7849 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Y)117(our situation is shared by others with PKD, but, for)18(tunately)116(, pain of this severity is limited to fewer than 10 percent. It is)]TJ 0 -1.2 TD [(ver)-18(y difficult to pinpoint the exact cause of severe chronic pain in most cases, but occasionally kidney stones, kidney infec)1(-)]TJ T* [(tions, kidney bleeding, blockage of the drainage tubes or kidney tumor may be found and cor)-18(rected. W)79(e do not know the)]TJ T* [(cause of pain in those individuals without obvious cause. W)79(e suspect that there may be inflammation in the kidneys)]TJ T* [(caused by the cysts, but this is only a theor)-18(y at the present time. Some patients get relief from an operation that removes)]TJ ET BT /F0 1 Tf 9 0 0 9 461.1341 36.4268 Tm /CS0 cs 0.5 scn 0.2778 Tc 0.0278 Tw (Q&A on PKD)Tj 9.8731 0 Td 1 scn (39)Tj /F7 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj /F7 1 Tf 0.27802 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj /F7 1 Tf 0.27802 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj ET Q endstream endobj 52 0 obj << /Length 6022 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F10 1 Tf 10 0 0 10 72 712.9834 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (hundreds of cysts from the kidneys, but this treatment has not been widely applied in the United States. Others have)Tj 0 -1.2 TD (been helped by clinics that specialize in the management of chronic pain by injection, biofeedback, transcutaneous stimu)Tj 49.84427 0.00001 TD 0 Tc (-)Tj -49.84427 -1.19999 TD -0.015 Tc 0.025 Tw [(lators and local injections of pain-killing dr)-18(ugs. If these measures fail, it may be necessar)-18(y to resor)-18(t to analgesics, but)]TJ 0 -1.2 TD 0.0251 Tw (many of these may potentially damage polycystic kidneys (acetaminophen, aspirin, and ibuprofen). This is an area of PKD)Tj T* 0.025 Tw [(management that continues to fr)-18(ustrate patients and physicians.)]TJ ET BT /F0 1 Tf 18 0 0 18 72 611.1506 Tm /CS0 cs 0.5 scn -0.0001 Tc (Pain)Tj 12 0 0 12 72 581.8339 Tm 1 scn 0 Tc 0.028 Tw [(Is the amount of pain in polycystic kidney disease r)18(elated to the stage of the disease?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 556.9838 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(P)23(ain in polycystic kidneys occurs for a number of reasons. Many acute pain syndromes occur when there is bleeding into)]TJ 0 -1.2 TD [(a cyst or the development of a new cyst or kidney infection. T)167(ypically)116(, the pain in these situations is rapid in onset and)]TJ 0 -1.19999 TD [(localized to the area where bleeding or infection is occur)-18(ring. T)134(reatment of the problem in these situations usually tak)19(es)]TJ 0 -1.2 TD -0.0151 Tc 0.0251 Tw (care of the pain. )Tj 0 -2.39999 TD -0.015 Tc 0.025 Tw [(Chronic pain in ADPKD is usually due to the size of the kidneys or liver)56(. Kidney size can increase up to 20 lbs in an)]TJ 0 -1.2 TD 0.0251 Tw (ADPKD individual. The pain in these individuals is due to multiple reasons. Sheer weight of the kidney is one obvious)Tj T* 0.025 Tw [(cause. The weight can pull back muscles out of alignment and change the usual suppor)-18(t patter)-18(ns that these muscles)]TJ T* [(provide to the spinal column. This can result in changes in the pathways that ner)-18(ves tak)19(e as they come out of the spinal)]TJ 0 -1.19999 TD [(column and result in compression or aggravation of the ner)-18(ve root. Impor)-18(tantly)116(, back pain in ADPKD may be muscu-)]TJ 0 -1.2 TD [(losk)18(eletal, but the original cause of the pain may be kidney size. There are individuals who tolerate the increased size of)]TJ T* [(the kidney ver)-18(y well. It is not clear why some and not others can be so severely affected with pain. )]TJ ET BT /F0 1 Tf 12 0 0 12 72 387.4344 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(How can one tell if pain is fr)18(om polycystic kidneys or liver)91(, and what ar)18(e the symptoms of)]TJ 0 -1.19999 TD -0.0002 Tc 0.0278 Tw (a cyst ruptur)Tj 5.87076 0 TD (e?)Tj ET BT /F10 1 Tf 10 0 0 10 72 348.1843 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(P)23(ain from cyst r)-18(upture is usually localized to the area where the cyst lies. Therefore, liver cyst r)-18(upture usually results in)]TJ 0 -1.19999 TD -0.0151 Tc 0.0251 Tw (pain over the front of the abdominal wall, with localization more of)Tj 27.58053 0 TD -0.015 Tc (ten to the right upper quadrant. These events are)Tj -27.58053 -1.2 TD (stressful, and a low-grade temperature may accompany this. Blood is not usually detected in the urine of an individual)Tj T* 0.025 Tw [(who has a r)-18(uptured liver cyst. However)56(, this of)-19(ten does occur in individuals who have a r)-18(uptured kidney cyst. Ruptured)]TJ 0 -1.19999 TD [(kidney cysts usually produce pain in areas lower than the liver and of)-18(ten in the flank or lateral area. Blood in the urine can)]TJ 0 -1.2 TD 0.0251 Tw (accompany these events, of)Tj 11.36769 0.00001 TD (ten visible to the eye (macroscopic hematuria) or just seen under the microscope and not)Tj -11.36769 -1.20001 TD 0.025 Tw [(visible to the eye (microscopic hematuria). P)23(ain is of)-18(ten present and can be difficult to control. When a cyst r)-18(uptures,)]TJ 0 -1.2 TD [(there are a number of things that you can do to limit the time of discomfor)-18(t or bleeding. This includes adequate hydra-)]TJ 0 -1.19999 TD [(tion, blood pressure control, and if bleeding persists af)-18(ter 48 hours, bed rest is also helpful in limiting the duration of pain.)]TJ 0 -1.2 TD 0.0251 Tw (Clearly your physician needs to know if this occurs. )Tj ET BT /F0 1 Tf 12 0 0 12 72 202.6348 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(Is ther)18(e an analgesic (pain killer) of choice for the PKD patient?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 177.7848 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(This is a difficult problem for PKD patients that has been made even more problematic by a repor)-18(t in the New England)]TJ 0 -1.2 TD [(Jour)-18(nal of Medicine that suggests that acetaminophen may injure the kidneys if tak)19(en for long periods of time. It appears,)]TJ 0.0251 Tw (therefore, that no analgesics can be used with impunity)' 22.68472 0.00001 TD (. Codeine and other narcotics can lead to dependency or addic)Tj 26.17629 0.00001 TD 0 Tc (-)Tj -48.86101 -1.2 TD -0.015 Tc (tion. Non-steroidals (aspirin, ibuprofen, naproxyn and several more) can reduce the flow of blood through the kidneys)Tj T* 0.025 Tw [(and aggravate high blood pressure. Acetaminophen can probably be used in small doses for shor)-18(t periods of time)]TJ 0.0251 Tw (without injuring the kidneys, but patients with chronic, severe pain may have to consult a specialized pain clinic in order)' T* 0.025 Tw [(to consider alter)-18(native types of treatment. )]TJ ET /GS0 gs 1 w /CS0 CS 1 SCN 66.492 604.308 m 570.492 604.308 l S /GS2 gs BT /F0 1 Tf 9 0 0 9 40.4999 36.4268 Tm /CS0 cs 1 scn 0.2778 Tc 0.0278 Tw (40 )Tj 2.8349 0 Td 0.5 scn (Q&A on PKD)Tj /F7 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj /F7 1 Tf 0.27802 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj ET Q endstream endobj 53 0 obj << /Length 5724 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 12 0 0 12 36 711.4336 Tm /CS0 cs 1 scn 0.028 Tw [(I have been on dialysis four years and am doing well except for unr)18(elenting kidney pain. I)]TJ 0 -1.2 TD [(am inter)18(ested in having a transplant, but I want a better quality of life if I go to the tr)17(ouble.)]TJ 0 -1.19999 TD [(W)18(ould it be best to have my diseased kidneys taken out befor)18(e the transplant?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 657.7835 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(This is one of the most common issues facing PKD patients who are awaiting transplants. Opinions var)-18(y among transplant)]TJ 0 -1.19999 TD -0.0149 Tc 0.0251 Tw (physicians and surgeons regarding the need to remove all polycystic kidneys before transplantation. Some surgeons insist)Tj 0 -1.2 TD -0.015 Tc (that all kidneys be removed before the transplant, whereas other equally successful surgeons remove the kidneys only if)Tj T* 0.025 Tw [(there is evidence of infection, persistent bleeding, tumors, stones, excessive size or debilitating pain. Until recently)117(, one)]TJ 0 -1.19999 TD [(reason to leave the old, non-functional kidneys in place was their capacity to mak)19(e a hor)-18(mone that k)18(eeps the red blood)]TJ 0 -1.2 TD 0.0251 Tw (count relatively high. )Tj 0 -2.39999 TD 0.025 Tw [(Er)-18(ythropoietin has been approved by the FD)37(A for use in anemic dialysis patients. This hor)-18(mone will improve blood)]TJ 0 -1.2 TD 0.0251 Tw (counts in anemic dialysis patients and improve the way they feel. Thus, PKD patients can have their kidneys removed)Tj T* 0.025 Tw [(without fear of developing debilitating anemia. On the other hand, if the old PKD kidneys have continued to mak)19(e signifi-)]TJ 0.0251 Tw (cant amounts of urine (more than 500 cc per day), dialysis patients will lose this amount of extra water they can drink if)' 0 -1.19999 TD (the kidneys are removed. Thorough discussion among members of the transplant team and the patient is indicated in)Tj 0 -1.2 TD (each case before pretransplant nephrectomy is done.)Tj ET BT /F0 1 Tf 18 0 0 18 36 459.951 Tm /CS0 cs 0.5 scn -0.0001 Tc 0.0278 Tw (General Information)Tj 12 0 0 12 36 430.6343 Tm 1 scn 0 Tc 0.028 Tw [(If one kidney is r)18(emoved fr)17(om an individual with PKD, will the cysts in the other kidney)]TJ 0 -1.2 TD [(gr)17(ow faster?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 391.3842 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Many patients with PKD have had one of their kidneys removed because of infection, stone, tumor or accidental injur)-18(y)116(.)]TJ 0 -1.19999 TD 0.0251 Tw (Experience has not indicated that the remaining polycystic kidney grows any faster than it might were the other kidney)Tj 0 -1.2 TD -0.0152 Tc (lef)Tj 1.00388 0 TD -0.015 Tc (t in place. As indicated previously in PKD Progress, it is difficult to judge just how fast the polycystic disease will)Tj -1.00388 -1.2 TD (progress in an individual. Only about one-half of those with PKD will develop kidney failure in their lifetime; the)Tj (remainder may have few complications of the disease. Thus, when a kidney is removed from an individual, one does not)' 0 -1.19999 TD (know whether that person was destined to develop renal failure or not. Nephrologists are ver)Tj 38.72495 0 TD (y reluctant to remove poly)Tj 10.86423 0 TD 0 Tc (-)Tj -49.58918 -1.20001 TD -0.015 Tc (cystic kidneys from individuals with good-to-moderate levels of renal function. On the other hand, for those already)Tj 0 -1.2 TD 0.025 Tw [(enrolled in a chronic dialysis program or who have received a successful renal transplant, nephrologists are more lik)19(ely to)]TJ 0 -1.19999 TD [(recommend removal of polycystic kidneys that are causing discomfor)18(t or other medical complications. )]TJ ET BT /F0 1 Tf 12 0 0 12 36 257.8348 Tm /CS0 cs 1 scn -0.0002 Tc (Ar)Tj 1.00097 0 TD 0.0278 Tw (e ther)Tj 2.65816 0 TD -0.0001 Tc (e any dangers to a PKD patient flying in an unpr)Tj 22.29909 0 TD (essurized airplane? )Tj ET BT /F10 1 Tf 10 0 0 10 36 232.9846 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (The dangers to a PKD patient from flying in an unpressurized airplane as a passenger are not different from those to an)Tj 0 -1.19999 TD 0.025 Tw [(individual without PKD. Because of the increased risk for intracranial aneur)-18(ysms, it has been recommended that PKD)]TJ 0 -1.2 TD 0.0251 Tw (patients fly an airplane with a copilot or as a copilot. )Tj ET BT /F0 1 Tf 12 0 0 12 36 171.435 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (What is the average life expectancy for an individual with the adult form of PKD?)Tj ET BT /F10 1 Tf 10 0 0 10 36 146.5847 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (The life expectancy of individuals with the adult for)Tj 21.07837 0.00001 TD (m of PKD is much better than thought years ago. In general, this is)Tj -21.07837 -1.19999 TD 0.025 Tw [(due par)-18(tially to milder for)-18(ms of the disease being diagnosed more frequently)116(, better preventive medicine and medical)]TJ 0 -1.2 TD [(care, and to the success of dialysis and renal transplantation. F)42(or these reasons, the estimated mean life expectancy of)]TJ 0.0251 Tw (PKD patients in a recent study approaches that of the general population, while it was 15 years shor)' 41.03225 0.00001 TD -0.0149 Tc (ter in older studies. )Tj ET /GS0 gs 1 w /CS0 CS 1 SCN 36 452.913 m 540 452.913 l S /GS2 gs BT /F0 1 Tf 9 0 0 9 461.1341 36.4268 Tm /CS0 cs 0.5 scn 0.2778 Tc 0.0278 Tw (Q&A on PKD)Tj 9.8731 0 Td 1 scn (41)Tj /F6 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj ET Q endstream endobj 54 0 obj << /Length 6258 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 12 0 0 12 72 711.4336 Tm /CS0 cs 1 scn 0.028 Tw [(Why do some PKD patients develop distended abdomens and others don\325)18(t? Does it have)]TJ 0 -1.2 TD -0.0001 Tc 0.0278 Tw (anything to do with the location of the kidneys (lower/higher)?)Tj ET BT /F10 1 Tf 10 0 0 10 72 672.1835 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (The distention of the abdomen in some patients with polycystic kidney disease is caused by extremely large polycystic)Tj 0 -1.2 TD 0.025 Tw [(kidneys, polycystic liver)56(, or both. The reason why some patients develop more severe enlargement of these organs than)]TJ 0 -1.19999 TD 0.0251 Tw (others is not known. Of interest is that polycystic liver disease tends to be more severe in women than in men, while)Tj 0 -1.2 TD 0.025 Tw [(polycystic kidney disease is slightly more severe in men than in women. Cer)-18(tain body configurations, obesity)116(, and rarely)116(,)]TJ 0 -1.20001 TD 0.0251 Tw (fluid accumulation can also contribute to abdominal distention in some patients with large polycystic kidneys or polycystic)Tj 0 -1.19999 TD 0 Tw [(liver)56(. )]TJ ET BT /F0 1 Tf 18 0 0 18 72 558.3508 Tm /CS0 cs 0.5 scn -0.0001 Tc (ADPKD/ARPKD)Tj 12 0 0 12 72 529.0341 Tm 1 scn -0.011 Tc 0.028 Tw [(Our youngest child was bor)-18(n with ARPKD last year and lived for only 3 weeks. T)111(wo older)]TJ 0 -1.2 TD [(childr)18(en (ages 3 and 2) appear healthy)92(. W)17(e have r)18(eceived conflicting advice r)18(egar)17(ding the)]TJ T* [(need to test our older childr)18(en for ARPKD symptoms. What advice can you give a par)18(ent)]TJ 0 -1.19999 TD 0 Tc (r)Tj 0.32287 0 TD -0.0113 Tc (egar)Tj 1.99412 0 TD -0.011 Tc [(ding the car)18(e of childr)17(en who have lost a sibling to the infantile form of PKD (ARPKD)?)]TJ -2.317 -1.2 TD -0.0113 Tc 0.0278 Tw (At what age would the risk of developing ARPKD symptoms disappear \(i.e. is it safe to say)Tj -0.0112 Tc (that a child has not inherited the disease if he has survived past two years-of-age?\))' ET BT /F10 1 Tf 10 0 0 10 72 432.1841 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(A)19(utosomal recessive polycystic kidney disease is a rare disorder)56(, occur)-19(ring in approximately 1:20,000 individuals. This)]TJ 0 -1.2 TD 0.0251 Tw (disease results from the mutated gene being inherited from both mother and father who are car)Tj 39.61363 0 TD (riers for the gene but are)Tj -39.61363 -1.19999 TD 0.025 Tw [(not affected with the disease. The gene responsible for ARPKD has been identified, and mutations are now being deter)1(-)]TJ 0 -1.2 TD 0.0251 Tw (mined in ARPKD individuals. This means that it is soon going to be possible to screen for the presence of ARPKD in)Tj (individuals at risk for the disease. The gene responsible for ARPKD is on chromosome 6, and no other genes responsible)' 0 -1.19999 TD 0.025 Tw [(for ARPKD have been identified. Given that you and your husband are car)-18(riers for ARPKD, it is cer)-18(tainly possible to)]TJ 0 -1.2 TD [(screen your children genetically for the disease. However)56(, as with ADPKD, a genetic diagnosis does not provide prog-)]TJ T* [(nostic infor)-18(mation. )]TJ 0 -2.39999 TD [(ARPKD affects both kidneys and the liver)56(. A)18(ffected individuals may have significant kidney involvement at the time of)]TJ 0 -1.2 TD [(bir)-18(th, meaning ver)-18(y enlarged kidneys and decreased urine production. This results in difficulty with breathing that ulti-)]TJ 0 -1.19999 TD [(mately is responsible for the death of these infants. How of)-18(ten ARPKD infants die at the time of bir)-18(th is not known;)]TJ 0 -1.2 TD -0.0151 Tc (however)Tj 3.49293 0.00001 TD -0.015 Tc 0.0251 Tw (, it does not happen in all ARPKD babies. Impor)Tj 19.94731 0.00001 TD 0.025 Tw [(tantly)116(, for those children who sur)-18(vive the first month of life,)]TJ -23.44024 -1.20001 TD [(s)-1(u)-1(r)-19(vival rates are ver)-18(y good, in fact much greater than 80%. When ARPKD infants sur)-18(vive, they have a number of medical)]TJ 0 -1.2 TD [(problems that require attention. Most commonly these children have hyper)-18(tension that requires medication. As well, the)]TJ 0 -1.19999 TD [(liver involvement in ARPKD is slowly progressive and can become symptomatic any time in childhood. The liver involve)1(-)]TJ 0 -1.2 TD 0.0251 Tw (ment in ARPKD is due to congenital hepatic fibrosis. This process results in dilation of the intra-hepatic bile ducts)Tj T* 0.025 Tw [(associated with peripor)-18(tal fibrosis. This process continues until the liver ultimately develops por)-18(tal hyper)-18(tension. The)]TJ 0 -1.19999 TD [(complications encountered related to the intra-hepatic bile duct dilation include biliar)-18(y stones and infection. These)]TJ 0 -1.2 TD 0.0251 Tw (complications are serious and can be life threatening, and, should symptoms of fever or abdominal pain develop in)Tj T* 0.025 Tw [(someone with ARPKD, he or she should see their doctor immediately)116(. Other complications of congenital hepatic fibrosis)]TJ 0 -1.19998 TD 0.0251 Tw (include esophageal varices. The veins lining the esophagus \(the tube that car)Tj 31.93081 0.00001 TD (ries food from your mouth to your stomach\))Tj -31.93081 -1.20001 TD (enlarge and tend to burst and bleed when por)Tj 19.05356 0.00001 TD -0.0151 Tc (tal hyper)Tj 3.63463 0.00001 TD -0.0149 Tc (tension in the liver is present. This results in massive bleeding into)Tj -22.68819 -1.20001 TD -0.015 Tc 0.025 Tw [(the stomach, which is also dangerous and life threatening. F)42(or children at risk for ARPKD who either have not or do not)]TJ 0 -1.2 TD -0.0149 Tc 0.0251 Tw (wish to undergo ultrasound examinations or genetic screening for ARPKD, it is wise to mak)Tj 37.50718 0.00001 TD -0.015 Tc (e sure that their physicians)Tj -37.50718 -1.2 TD -0.0151 Tc (know that they are at risk for ARPKD so that, should complications develop, they can act quickly)Tj 39.46584 0.00001 TD (. )Tj ET /GS0 gs 1 w /CS0 CS 1 SCN 72 551.08 m 576 551.08 l S /GS2 gs BT /F0 1 Tf 9 0 0 9 40.4999 36.4268 Tm /CS0 cs 1 scn 0.2778 Tc 0.0278 Tw (42 )Tj 2.8349 0 Td 0.5 scn (Q&A on PKD)Tj /F6 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj ET Q endstream endobj 55 0 obj << /Length 6355 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 12 0 0 12 36 711.4336 Tm /CS0 cs 1 scn 0.028 Tw [(Our childr)18(en ar)17(e at risk for ADPKD. Given the potential pr)18(oblems with medical insurance,)]TJ 0 -1.2 TD [(we ar)18(e r)17(eluctant to have them undergo scr)18(eening for ADPKD. What do you suggest?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 672.1835 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(This is a difficult question without a straightfor)-18(ward answer)56(. There are treatable complications that are undetected in)]TJ 0 -1.2 TD [(almost 60% of patients due to ADPKD. Complications include hyper)18(tension, urinar)-18(y tract infections and hematuria or)]TJ 0 -1.19999 TD 0.0251 Tw (blood in the urine. These conditions contribute to disease progression in ADPKD. However)Tj 38.15325 0.00001 TD -0.0149 Tc (, a diagnosis of an inherited)Tj -38.15325 -1.20001 TD -0.015 Tc (kidney disease can limit access to life and health insurance coverage, and for those whose employment provides excellent)Tj 0 -1.2 TD 0.025 Tw [(health insurance coverage, a diagnosis can alter a decision regarding change of employment. These issues have tremen)1(-)]TJ 0 -1.19999 TD -0.0149 Tc 0.0251 Tw (dous impact with regard to undergoing screening for a diagnosis of ADPKD. )Tj 0 -2.4 TD -0.015 Tc 0.025 Tw [(An alterative to undergoing screening for a diagnosis of ADPKD is that at-risk individuals can practice universal precau)1(-)]TJ 0 -1.19999 TD [(tions, i.e., assume that ever)-18(yone at risk has ADPKD and treat accordingly)116(. This would include having a home blood)]TJ 0 -1.20001 TD [(pressure measuring device, having a physician obtain blood pressure measurements and check urinalyses regularly)117(, and)]TJ 0.0251 Tw (having blood work done to measure kidney function. Should symptoms develop, such as flank pain, back pain, pain with)' 0 -1.2 TD 0.025 Tw [(urination, or blood in the urine, a fast refer)-18(ral to a nephrologist could then be made available. Impor)-18(tantly)116(, the field of)]TJ 0 -1.19999 TD [(scientific investigation in ADPKD is making tremendous progress, and, with the cur)-18(rent pace and an increased under-)]TJ 0 -1.2 TD 0.0251 Tw (standing of the PKD genes and their protein products, specific therapy may soon be available. Those diagnosed early with)Tj T* 0.025 Tw [(ADPKD would benefit the most from such therapies. All of these issues mak)19(e this decision a case-by)19(-case and year)37(-by)18(-year)]TJ 0 -1.19999 TD [(consideration. It is wor)-18(thwhile to discuss all questions and concer)-18(ns with your health care provider before proceeding)]TJ 0 -1.2 TD 0.0251 Tw (with a screening test for the presence of ADPKD. )Tj ET BT /F0 1 Tf 12 0 0 12 36 442.6343 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (I have PKD and am a 37-year)Tj 13.54049 0 TD (-old woman. Last week, my 11-year)Tj 16.81808 0 TD (-old daughter was found)Tj -30.35857 -1.2 TD 0 Tc 0.028 Tw [(to have elevated blood pr)18(essur)17(e and kidney cysts by ultrasound test. She is r)18(eceiving)]TJ 0 -1.19999 TD [(Enalapril. Isn\325)18(t this a little early for PKD to show up? Does this early diagnosis mean)]TJ 0 -1.2 TD -0.0003 Tc (mor)Tj 1.79663 0 TD -0.0001 Tc 0.0278 Tw (e than the usual tr)Tj 8.40801 0 TD (ouble ahead for her?)Tj ET BT /F10 1 Tf 10 0 0 10 36 374.5843 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (Her results indicate that she has inherited ADPKD. The fact that she has elevated blood pressure is unfor)Tj 43.40079 0 TD -0.0149 Tc (tunate but not)Tj -43.40079 -1.2 TD -0.015 Tc 0.025 Tw [(unusual. Approximately 15% of ADPKD children have hyper)-18(tension. High blood pressure is impor)-18(tant to identif)-18(y and)]TJ T* [(treat, as it is accompanied by disease progression in ADPKD children mark)19(ed by increases in renal size and cyst number)56(.)]TJ 0 -1.19999 TD [(Impor)-18(tantly)116(, the majority of ADPKD children have high blood pressure and are not aware of their condition. If she)]TJ 0 -1.2 TD [(controls her blood pressure and tak)19(es her medications regularly)116(, she may be able to slow down progression of her renal)]TJ 0.0251 Tw (disease. )' ET BT /F0 1 Tf 12 0 0 12 36 277.0347 Tm /CS0 cs 1 scn -0.0001 Tc 0.0278 Tw (What kind of cystic diseases do childr)Tj 17.66988 0 TD (en have?)Tj ET BT /F10 1 Tf 10 0 0 10 36 252.1845 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (There are four major kinds of cystic disease that can be seen in infancy and childhood. The most common kind is called)Tj 0 -1.2 TD 0.025 Tw [(\322multicystic displasia.\323 It may occur in only one kidney or both and is frequently associated with an obstr)-18(uction or)]TJ 0.0251 Tw (absence of the ureter (the tube leading from the kidney to the bladder). It may be seen in children with some kinds of)' 0 -1.19999 TD 0.025 Tw [(congenital malfor)-18(mation syndromes or may be an isolated entity)116(. It is rarely inherited. )]TJ ET BT /F0 1 Tf 12 0 0 12 36 178.635 Tm /CS0 cs 1 scn -0.0002 Tc 0.0278 Tw (What ar)Tj 3.602 0 TD -0.0001 Tc (e the qualifications of a pediatric nephr)Tj 18.17013 0 TD (ologist, and does the pediatric nephr)Tj 17.10401 0 TD -0.0002 Tc (ologist)Tj -38.87614 -1.20002 TD 0 Tc 0.028 Tw [(dif)18(fer fr)17(om a r)18(egular pediatrician?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 139.3849 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (The word \322nephros\323 means kidney in Greek. Hence, the pediatric nephrologist cares for children with kidney diseases.)Tj 0 -1.2 TD 0.025 Tw [(This is in contrast to the pediatric urologist, who is a surgeon who deals with operable conditions of the genitourinar)-18(y)]TJ T* [(tract, including congenital anatomical abnor)-18(malities and obstr)18(uctions to urine flow)111(. )]TJ 0 -2.4 TD 0.0251 Tw (A general pediatrician receives three years of training in pediatrics following medical school. In general, they have one to)Tj 0 -1.2 TD 0.025 Tw [(several months, but they must rotate through all other subspecialties \(such as neurology [ner)-18(vous system diseases] and)]TJ ET BT /F0 1 Tf 9 0 0 9 461.1341 36.4268 Tm /CS0 cs 0.5 scn 0.2778 Tc 0.0278 Tw (Q&A on PKD)Tj 9.8731 0 Td 1 scn (43)Tj /F6 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj ET Q endstream endobj 56 0 obj << /Length 6722 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F10 1 Tf 10 0 0 10 72 712.9834 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(neonatology [newbor)-18(n medicine]\) as well as spend time caring for children with routine pediatric problems. The pedi-)]TJ 0 -1.2 TD 0.0251 Tw (atric nephrologist spends those three years in the same way)Tj 24.51455 0.00001 TD (, but then has an additional two to three years in which he/she)Tj -24.51455 -1.19999 TD 0.025 Tw [(cares only for children with kidney diseases in order to lear)-18(n extensively and intensively about the diagnosis and manage-)]TJ 0 -1.2 TD [(ment of such diseases. General pediatrics has a \322board\323 exam following the first three years. P)24(assing that exam qualifies)]TJ T* [(the doctor to be a \322board-cer)-18(tified pediatrician.\323 P)42(ediatric nephrology also has a cer)-18(tif)-18(ying examination that may be tak)18(en)]TJ 0 -1.19999 TD [(af)-18(ter the two- to three-year fellowship. The doctor then becomes a \322board-cer)-18(tified pediatric nephrologist.\323 )]TJ ET BT /F0 1 Tf 12 0 0 12 72 615.4338 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(Should my child with PKD go to a pediatric nephr)18(ologist?)]TJ ET BT /F10 1 Tf 10 0 0 10 72 590.5837 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(PKD in children is an uncommon disease. P)42(ediatric nephrologists have trained in major pediatric centers that have large)]TJ 0 -1.2 TD [(refer)-18(ral areas, so the pediatric nephrologist sees several children with PKD during training. On the other hand, the pedia)1(-)]TJ 0 -1.19999 TD [(trician-in-training might see only one or no such patients. Obviously)116(, then, the pediatric nephrologist knows far better)]TJ 0 -1.2 TD [(how to care for such children. If there is no pediatric nephrologist in your area, it is per)-18(fectly appropriate to ask your)]TJ 0 -1.20001 TD [(pediatrician to send your child for a consultation with a pediatric nephrologist in a university center)56(. The consultant will)]TJ 0 -1.19999 TD [(then help the pediatrician plan an appropriate management strategy and educate the pediatrician on the ways to obser)-18(ve)]TJ 0 -1.2 TD 0.0251 Tw (your child. )Tj ET BT /F0 1 Tf 12 0 0 12 72 481.0342 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(Why does polycystic disease af)18(fect a fetus so quickly and fatally)91(, while it takes years in an)]TJ 0 -1.2 TD -0.0001 Tc (adult?)Tj ET BT /F10 1 Tf 10 0 0 10 72 441.7841 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (The quick answer is, we don\325t know)Tj 14.71578 0 TD -0.0151 Tc (. Medical research has revealed recently)Tj 16.4509 0 TD (, however)Tj 3.98985 0 TD -0.015 Tc (, that in the rapidly fatal type of)Tj -35.15653 -1.20001 TD 0.025 Tw [(recessive PKD, nearly all of the kidney tubules are altered by cyst for)-18(mation. By contrast, in the autosomal dominant)]TJ 0 -1.19999 TD -0.0148 Tc (for)Tj 1.17868 0 TD -0.0151 Tc 0.0251 Tw (m, only a small percentage of the tubules are affected with cysts. It may be that each cyst must grow to a much larger)Tj -1.17868 -1.2 TD -0.015 Tc 0.025 Tw [(extent to cause damage when they are few in number)56(, thus delaying kidney malfunction in the adult. )]TJ ET BT /F0 1 Tf 12 0 0 12 72 368.2345 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(My daughter was bor)-18(n with adult PKD, and I carry it. \(I am under no tr)18(eatment at this)]TJ 0 -1.2 TD -0.0001 Tc 0.0278 Tw (time.\) She just tur)Tj 8.49835 0 TD (ned six months, and it br)Tj 11.5647 0 TD (eaks my heart that this happened to her)Tj 18.49137 0 TD (. She)Tj -38.55442 -1.20001 TD (is the only one of 13 of)Tj 10.61471 0 TD (fspring in our family to whom this happened at birth. Why?)Tj ET BT /F10 1 Tf 10 0 0 10 72 314.5844 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(The autosomal dominant (adult) type of PKD is present at bir)-18(th in the kidneys of individuals who have inherited the gene,)]TJ 0 -1.2 TD [(but the degree to which the cysts are expressed varies greatly from person to person. W)19(ith the almost routine use of)]TJ 0 -1.19999 TD [(sonography (sound wave testing) during pregnancy)116(, many more cases of PKD are being discovered in unbor)-18(n children. If)]TJ 0 -1.2 TD 0.0251 Tw (the cysts are discovered in the fetus or newbor)Tj 19.28742 0.00001 TD (n baby as an incidental finding \(that is, no symptoms directed the physician)Tj -19.28742 -1.20001 TD (to look for the disease\), the outlook is no different than for anyone with the autosomal dominant type of PKD. However)Tj 49.72336 0.00001 TD 0 Tc (,)Tj -49.72336 -1.19999 TD -0.015 Tc (recent studies of children in the University of Colorado polycystic kidney research program have indicated that, early in)Tj 0 -1.2 TD (life, some children with ADPKD may develop problems. If a child with PKD develops signs or symptoms, treatment)Tj (should be star)' 5.84319 0.00001 TD -0.0151 Tc (ted immediately and followed with regular health checks. A)Tj 24.65225 0.00001 TD -0.0149 Tc (ffected children without signs or symptoms of)Tj -30.49544 -1.2 TD -0.015 Tc 0.025 Tw [(PKD should have regular checks for high blood pressure and urinar)-18(y tract infections. )]TJ ET BT /F0 1 Tf 12 0 0 12 72 181.0349 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(I have PKD, as did my mother)92(. My 8-year)54(-old daughter was bor)18(n with only one kidney)92(, but)]TJ 0 -1.19999 TD [(the r)18(emaining one is of normal shape, size and function. W)17(e have not had any kidney)]TJ 0 -1.2 TD -0.0001 Tc 0.0278 Tw (tests done to look for PKD. Could the missing kidney be due to PKD, and should we be)Tj 0 -1.19999 TD (taking any special pr)Tj 9.62291 0 TD (ecautions?)Tj ET BT /F10 1 Tf 10 0 0 10 72 112.9849 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Although dominantly inherited PKD (ADPKD) can of)-18(ten be detected in childhood, this condition is not ordinarily associ-)]TJ 0 -1.2 TD 0.0251 Tw (ated with congenital abnor)Tj 11.03688 0.00001 TD (malities such as solitar)Tj 9.18639 0.00001 TD -0.0149 Tc (y kidney)Tj 3.33647 0.00001 TD -0.015 Tc (, so finding only one kidney has no special significance. A)Tj -23.5597 -1.2 TD (solitar)Tj 2.5093 0 TD (y kidney is relatively common in the populations at large and does not usually lead to serious problems of renal)Tj -2.5093 -1.2 TD 0.025 Tw [(function. Occasionally)116(, the kidney will excrete more protein in the urine than nor)-18(mal, and some researchers have)]TJ ET BT /F0 1 Tf 9 0 0 9 40.4999 36.4268 Tm /CS0 cs 1 scn 0.2778 Tc 0.0278 Tw (44 )Tj 2.8349 0 Td 0.5 scn (Q&A on PKD)Tj /F7 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj /F7 1 Tf 0.27802 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj /F7 1 Tf 0.27802 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj ET Q endstream endobj 57 0 obj << /Length 6932 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F10 1 Tf 10 0 0 10 36 712.9834 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(suggested there may be a predilection to high blood pressure in individuals with only one kidney)117(. ADPKD does not)]TJ 0 -1.2 TD -0.0149 Tc 0.0251 Tw (appear to progress at an unusual rate in individuals with only one kidney)Tj 29.83938 0.00001 TD -0.015 Tc 0.025 Tw [(, but this infor)-18(mation is based on studies of older)]TJ -29.83939 -1.19999 TD [(individuals rather than children. It would seem reasonable to have a child with a solitar)-18(y kidney examined by a pediatric)]TJ 0 -1.2 TD [(nephrologist at periodic inter)-18(vals to check the level of kidney function and to monitor blood pressure. )]TJ T* [(T)167(wo of my grandchildren died shor)-18(tly af)-18(ter bir)-19(th due to infantile PKD. A third child is a bright, sociable 4 year)38(old, but she)]TJ 0 -1.19999 TD [(has cysts on her kidneys and liver)56(, and has high blood pressure. I wonder if it would be possible, in this age of genetic)]TJ 0 -1.2 TD 0.0251 Tw (engineering, to have one of the parents\325 genes altered to produce a pregnancy free of this disease?)Tj T* 0.025 Tw [(Despite the advances in genetic engineering, we are not yet at the point where we can cor)-18(rect genetic defects. The first)]TJ 0 -1.20001 TD [(experimental trials of these techniques are under)-18(way)116(, and intensive effor)-18(ts are being made toward the goal of \322gene)]TJ 0 -1.19999 TD [(therapy)116(.\323 Never)-18(theless, it will be some time before these techniques can be applied in inherited kidney disease \320 many)]TJ 0 -1.2 TD [(technical hurdles need to be overcome. In the meantime, a genetic counselor will be able to help your son/daughter)38(-in-)]TJ T* [(law evaluate the risk of PKD in a future pregnancy)116(. )]TJ ET BT /F0 1 Tf 12 0 0 12 36 543.434 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(My six-month-old daughter died of a virus that af)18(fected her heart. An autopsy disclosed)]TJ 0 -1.19999 TD [(autosomal r)18(ecessive PKD. W)17(e want to have other childr)18(en. What is the life span of this)]TJ 0 -1.2 TD [(disease? Is ther)18(e any tr)17(eatment, surgery)92(, medication or diet that would have helped?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 489.784 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (The viral disease that your daughter had was a separate disease from the autosomal recessive polycystic kidney disease)Tj 0 -1.2 TD 0.025 Tw [((ARPKD). ARPKD results in death in early infancy in about 60 percent of those who have it. Usually)117(, these babies die from)]TJ 0.0251 Tw (lung problems, but some of them may have kidney failure. The remaining children may do well for a number of years.)' 0 -1.19999 TD 0.025 Tw [(Some develop kidney failure fairly early and require dialysis or transplantation, and most children need that kind of treat)1(-)]TJ 0 -1.2 TD 0.0251 Tw (ment by or during adolescence. One of the most common problems associated with ARPKD in the child who sur)Tj 46.74035 0 TD -0.0148 Tc (vives is)Tj -46.74035 -1.2 TD -0.015 Tc 0.025 Tw [(high blood pressure. W)79(e believe that prompt and careful treatment of the blood pressure will help maintain kidney func)1(-)]TJ 0 -1.19999 TD -0.0149 Tc 0.0251 Tw (tion longer)Tj 4.48658 0 TD -0.015 Tc (. There is no specific treatment for ARPKD, so we are careful to treat all the symptoms of the disease as it)Tj -4.48658 -1.2 TD -0.0149 Tc (progresses. )Tj 0 -2.4 TD -0.015 Tc (Since you are hoping to have more children, you may wish to talk to a geneticist about the disease. The lik)Tj 44.0966 0 TD -0.0151 Tc (elihood that)Tj -44.0966 -1.19999 TD -0.015 Tc 0.025 Tw [(each future child might have the disease is one in four)56(, or 25 percent. Prenatal ultrasound examinations can sometimes,)]TJ 0 -1.2 TD [(but not always, detect the disease before bir)-18(th, and ultrasounds done sequentially af)-18(ter bir)-18(th will also help with early )]TJ -0.0148 Tc (diagnosis.)' ET BT /F0 1 Tf 12 0 0 12 36 308.2346 Tm /CS0 cs 1 scn -0.0002 Tc 0.0278 Tw (I just lost my first baby to \322bilateral cystic r)Tj 19.93708 0 TD -0.0001 Tc (enal dysplasia, polycystic kidneys.\323 The)Tj -19.93708 -1.2 TD 0 Tc 0.028 Tw [(doctor told me that this type is not a genetic disor)18(der)91(, just a mechanical fault. Ar)18(e ther)18(e)]TJ T* [(r)18(eally forms of PKD that ar)18(en\325)17(t genetic or r)18(ecessive?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 254.5846 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(Unlik)18(e the genetically transmitted polycystic kidney diseases (autosomal dominant and autosomal recessive), bilateral)]TJ 0 -1.2 TD [(cystic renal dysplasia is a sporadic condition caused by abnor)-18(mal development of the kidneys early in embr)-18(yonic life. The)]TJ 0.0251 Tw (cause of multicystic dysplasia is unknown and, in many instances, this kidney malfor)' 34.54061 0.00001 TD -0.0151 Tc (mation may be associated with malfor)Tj 15.55801 0.00001 TD 0 Tc (-)Tj -50.09862 -1.2 TD -0.015 Tc 0.025 Tw [(mations in other par)-18(ts of the body)116(. The bilateral cystic dysplastic kidney is considered to be nonhereditar)-18(y)116(. However)56(,)]TJ T* [(there are documented cases of familial recur)-18(rence of bilateral cystic dysplasia, par)-18(ticularly if there is a family histor)-18(y of)]TJ 0.0251 Tw (other urologic abnor)' 8.56677 0.00001 TD (malities present. In families without a histor)Tj 18.29357 0.00001 TD (y of renal disease, there appears to be a small \(1 percent)Tj -26.86034 -1.20001 TD 0.025 Tw [(to 3 percent\) risk of recur)-18(rence of this problem in subsequent children. )]TJ ET BT /F0 1 Tf 12 0 0 12 36 145.0349 Tm /CS0 cs 1 scn 0 Tc 0.028 Tw [(W)18(e understand that ther)18(e ar)17(e some pr)18(ojects underway to study autosomal r)18(ecessive poly)-1(-)]TJ 0 -1.19999 TD -0.0001 Tc 0.0278 Tw (cystic kidney disease, the type that af)Tj 17.55856 0 TD (fects infants. Wher)Tj 8.99204 0 TD (e do these stand, and what has)Tj -26.5506 -1.2 TD 0 Tc 0.028 Tw [(been lear)-18(ned so far? What can we do to help?)]TJ ET BT /F10 1 Tf 10 0 0 10 36 91.385 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(The road to understanding the abnor)-18(malities in ARPKD requires several approaches. If one could star)-18(t at the beginning,)]TJ 0 -1.2 TD [(one would look for the genetic abnor)-18(mality that produces a disease, deter)-18(mine whether that genetic abnor)-18(mality was a)]TJ 0.0251 Tw (single one or one of several abnor)' 14.04024 0.00001 TD (mal genes that produced several abnor)Tj 16.04392 0.00001 TD 0.025 Tw [(mal gene products, deter)-18(mine what the gene)]TJ ET BT /F0 1 Tf 9 0 0 9 461.1341 36.4268 Tm /CS0 cs 0.5 scn 0.2778 Tc 0.0278 Tw (Q&A on PKD)Tj 9.8731 0 Td 1 scn (45)Tj /F7 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj /F7 1 Tf 0.27795 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj /F7 1 Tf 0.27802 0 Td ( )Tj /F6 1 Tf 0.25098 0 Td ( )Tj ET Q endstream endobj 58 0 obj << /Length 4997 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F10 1 Tf 10 0 0 10 72 712.9834 Tm 0 0 0 1 k -0.015 Tc 0.025 Tw [(products were \(the proteins made by the genes that caused the abnor)18(mality\), then deter)-18(mine whether there were some)]TJ 0 -1.2 TD 0.0251 Tw (environmental factors that contributed to for)Tj 18.47101 0.00001 TD 0.025 Tw [(mation of the cysts, and, finally)116(, how to alter the one of many processes that)]TJ -18.47101 -1.19999 TD [(were abnor)-18(mal. Needless to say)116(, such a stepwise approach would tak)19(e a ver)-19(y long time. F)42(or that reason, it is impor)18(tant)]TJ 0 -1.2 TD [(that several processes be studied simultaneously)116(, a procedure that requires the exper)-18(tise of several different investigators)]TJ T* [(with several kinds of exper)-18(tise. )]TJ 0 -2.39999 TD [(F)42(or those who have children with ARPKD, researchers are star)18(ting a registr)-18(y and relatively soon will need blood samples)]TJ 0 -1.2 TD [(from your affected child/children as well as other family members. Y)116(ou may want to notif)-18(y PKD F)42(oundation of your will-)]TJ 0 -1.20001 TD 0.0251 Tw (ingness to be involved in research so that we will be able to contact you as appropriate needs arise.)Tj 0 -2.39999 TD 0.025 Tw [(A family wrote to ask if it were tr)-18(ue that there were four types of autosomal recessive or infantile polycystic kidney disease)]TJ 0 -1.2 TD [(and whether all affected children from one family would have the same type. This is a par)-18(ticularly wor)-18(risome question for)]TJ 0 -1.19999 TD [(those families who have a baby severely affected at bir)-18(th who quickly succumbs. )]TJ 0 -2.4 TD [(In 1971, two geneticists named Blyth and Ock)19(enden (J. Med Genet. 8:257, 1971) described ARPKD in children seen in)]TJ 0 -1.19999 TD [(London. They separated the children into four groups. A \322perinatal\323 group presented at bir)-18(th with huge abdominal)]TJ 0 -1.2 TD 0.0251 Tw (masses that were the enlarged kidneys. These babies died within the first six months of life. Microscopic examination of)Tj (their kidneys showed that 90 percent of the kidney tubules were cystic, whereas the fibrosis of the liver was minimal. A)' 0 -1.19999 TD (second \322neonatal\323 group presented from one day to one month of age with large kidneys. The majority of these babies)Tj 0 -1.2 TD 0.025 Tw [(had also died within the first six weeks of life. Sixty percent of the tubules were cystic, and the liver scar)-18(ring was a little)]TJ 0.0251 Tw (more obvious. A third \322infantile\323 group presented from three months to six months of age and had both enlarged)' T* 0.025 Tw [(kidneys and an enlarged liver)56(. The majority of these children developed kidney failure but not until several years of age.)]TJ 0 -1.19999 TD [(In addition, they had ver)-18(y increased pressures in the liver blood vessels \(called por)-18(tal hyper)-18(tension\). In these children,)]TJ 0 -1.2 TD [(only about 25 percent of the kidney tubules were cystic. F)19(inally)116(, a group called \322juvenile\323 presented in childhood under)]TJ T* [(the age of 5. The predominant symptom in them was the enlarged liver)56(, and por)-18(tal hyper)-18(tension was severe. Less than)]TJ 0 -1.19999 TD 0.0251 Tw (10 percent of the kidney tubules were cystic. )Tj 0 -2.4 TD (Several other repor)Tj 7.97514 0 TD (ts of children with ARPKD have suggested this separation, and several authors have suggested that the)Tj -7.97514 -1.19999 TD (affected children from a single family will always present the same way\321that is, if one child has the perinatal type, any)Tj 0 -1.2 TD (future child in that family who has ARPKD will fit in that same group. )Tj 0 -2.4 TD 0.025 Tw [(More recent infor)-18(mation says that this is not always tr)-18(ue. T)167(wo recent repor)-18(ts have made a point of noting that one child)]TJ 0 -1.19999 TD 0.0251 Tw (can present with the severe, perinatal for)Tj 16.86503 0 TD (m, and another will not develop severe disease until several years of age. Among)Tj -16.86503 -1.2 TD (our patients are several families whose presentations fit different types. On the other hand, there are some families in)Tj (which the group seems to \322breed tr)' 14.72359 0 TD 0.025 Tw [(ue.\323 That is, the affected children fit in the same group. Unfor)18(tunately)116(, there is no)]TJ -14.72359 -1.19999 TD 0.0251 Tw (way to predict in advance whether affected children will fall in the same or different groups. One needs to remember)Tj 48.37928 0.00001 TD 0 Tc (,)Tj -48.37928 -1.20001 TD -0.0151 Tc (however)Tj 3.49293 0.00001 TD (, that each child in an affected family has only a 25 percent chance of having the disease at all and a 75 percent)Tj -3.49293 -1.20001 TD -0.015 Tc (chance of not having the disease.)Tj ET BT /F0 1 Tf 9 0 0 9 40.4999 36.4268 Tm /CS0 cs 1 scn 0.2778 Tc 0.0278 Tw (46 )Tj 2.8349 0 Td 0.5 scn (Q&A on PKD)Tj /F7 1 Tf 1 0 0 1 -1000 1792 Tm 1 g 0 Tc 0 Tw ( )Tj /F6 1 Tf 0.25104 0 Td ( )Tj ET Q endstream endobj 59 0 obj << /Length 4572 >> stream /GS0 gs 1 g 0 792 0 0 re f /GS2 gs q BT /F0 1 Tf 18 0 0 18 36 707.1504 Tm /CS0 cs 0.5 scn -0.0001 Tc (Index)Tj ET /GS0 gs 1 w /CS0 CS 1 SCN 36 701.165 m 540 701.165 l S /GS2 gs BT /F10 1 Tf 10 0 0 10 36 680.7983 Tm 0 0 0 1 k -0.015 Tc 0.0251 Tw (ADPKD (autosomal dominant polycystic kidney disease))Tj 0.9 -1.2 TD 0 Tw [(Aneur)-18(ysms)]TJ -0.0151 Tc (Children)' 0 -1.19999 TD -0.0148 Tc (Diagnosis)Tj 0 -1.2 TD (Diet)Tj T* -0.015 Tc 0.025 Tw [(Dr)-18(ugs for)]TJ 0 -1.19999 TD 0 Tw [(Hyper)-18(tension)]TJ 0 -1.2 TD -0.0148 Tc 0.0251 Tw (Imaging studies)Tj -0.015 Tc (Incidence)' -0.0151 Tc (Mitral valve prolapse)' 0 -1.19999 TD -0.015 Tc (Physical fitness)Tj 0 -1.2 TD (Pregnancy)Tj T* 0.025 Tw [(T)135(ests for)]TJ 0 -1.19999 TD [(Urinar)-18(y tract infection)]TJ -0.9 -1.2 TD -0.0154 Tc (Alcohol)Tj T* -0.015 Tc 0 Tw [(Aneur)-18(ysms)]TJ 0.9 -1.19999 TD -0.0148 Tc (Brain)Tj 0 -1.2 TD -0.0151 Tc (Abdominal)Tj -0.9 -1.2 TD -0.015 Tc 0.0251 Tw (ARPKD (autosomal recessive polycystic kidney disease))Tj 0.9 -1.2 TD (Congenital hepatic fibrosis)Tj 0 -1.19999 TD 0 Tw [(Hyper)-18(tension)]TJ 0 -1.2 TD 0.0251 Tw (Incidence of)Tj -0.0148 Tc (Liver)' 0 -1.19999 TD -0.0149 Tc (Underdeveloped lungs)Tj -0.9 -1.2 TD -0.015 Tc (Caffeine)Tj (Computed tomogram)' 0 -1.19999 TD (Creatinine)Tj 0 -1.2 TD -0.0149 Tc (Cysts)Tj 0.9 -1.2 TD -0.0151 Tc (Arachnoid)Tj 0 -1.19999 TD -0.0149 Tc (Aspiration of)Tj 0 -1.2 TD -0.0148 Tc (Draining of)Tj -0.0149 Tc (Enlarged)' (Infection in)' 0 -1.19999 TD (Growth in)Tj 0 -1.2 TD -0.015 Tc 0.025 Tw [(Surger)-18(y for)]TJ -0.9 -1.2 TD (Dialysis)Tj 0.9 -1.19999 TD 0 Tw [(Diar)-18(rhea)]TJ 0 -1.2 TD 0.025 Tw [(Graf)-18(ts for)]TJ (Hemodialysis)' 0 -1.19998 TD -0.0148 Tc (Hypotension)Tj 0 -1.2 TD -0.0151 Tc (Nephrectomy)Tj (Nausea)' 0 Tc (P)' 0.46614 0.00001 TD -0.015 Tc 0.0251 Tw (eritoneal dialysis)Tj -1.36614 -1.19999 TD -0.014 Tc 0 Tw [(D)1(r)-17(ugs)]TJ 0.9 -1.2 TD -0.015 Tc (Acetaminophen)Tj -0.0147 Tc (Aspirin)' 0 -1.19999 TD -0.0152 Tc (Chloramphenicol)Tj -0.0151 Tc (Ciprofloxacin)' -0.015 Tc (Captopril)' -0.0151 Tc (Enalapril)' T* -0.015 Tc [(Er)-18(ythropoietin)]TJ -0.0149 Tc (Ibuprofen)' -0.015 Tc (Nor)' 1.5793 0 TD -0.0151 Tc (floxacin)Tj 24.22068 62.39983 TD (Phenacetin)Tj 0 -1.2 TD -0.0149 Tc (Propoxyphene)Tj -0.0151 Tc (Sulfamethoxozole)' 0 -1.19999 TD (Theophylline)Tj 0 -1.2 TD -0.015 Tc [(T)135(rimethoprim)]TJ -0.9 -1.20001 TD 0.025 Tw [(Fluid intak)19(e)]TJ 0 -1.19999 TD -0.0148 Tc (Genes)Tj 0.9 -1.2 TD -0.015 Tc [(ADPKD)-37(-1 chromosome 16)]TJ T* [(ADPKD)-37(-2 chromosome 4)]TJ -0.0151 Tc 0.0251 Tw (ARPKD chromosome 6)' 0 -1.19999 TD (Therapy)Tj -0.9 -1.2 TD -0.015 Tc 0 Tw [(Hyper)-18(tension)]TJ 0.9 -1.2 TD -0.0149 Tc 0.0251 Tw (Blood pressure)Tj 0 -1.19999 TD -0.015 Tc 0 Tw [(P)42(or)-18(tal)]TJ -0.9 -1.2 TD -0.0154 Tc (IVP)Tj -0.0149 Tc (Infection)' 0.9 -1.19999 TD (Bladder)Tj 0 -1.2 TD -0.015 Tc (Cyst)Tj -0.0149 Tc (Kidney)' (Urinar)' 2.60565 0 TD -0.015 Tc 0.0251 Tw (y tract)Tj -3.50565 -1.19999 TD -0.0149 Tc (Kidneys)Tj 0.9 -1.2 TD (Bleeding in)Tj -0.0151 Tc (Cadaver)' 0 -1.19999 TD -0.0149 Tc (Cysts in)Tj 0 -1.2 TD (Enlarged)Tj T* -0.015 Tc 0.025 Tw [(F)23(ailure of)]TJ 0 -1.19999 TD -0.0149 Tc 0.0251 Tw (Infection in)Tj 0 -1.2 TD -0.0148 Tc (Stones in)Tj 0 Tc (T)' 0.43147 0 TD -0.0149 Tc (ransplants)Tj -1.33147 -1.19999 TD -0.015 Tc (Laparoscopy)Tj 0 -1.2 TD -0.0148 Tc (Liver)Tj 0.9 -1.2 TD -0.0149 Tc (Cysts, drainage)Tj (Enlarged)' 0 -1.19999 TD -0.015 Tc 0.025 Tw [(Laparoscopic surger)-18(y)]TJ 0 -1.2 TD (Pregnancy)Tj -0.9 -1.2 TD 0.0251 Tw (Magnetic resonance angiography (MRI))Tj 0 -1.19999 TD -0.0151 Tc (Mitral valve prolapse)Tj 0 -1.2 TD -0.015 Tc 0 Tw [(P)23(ain)]TJ T* 0.025 Tw [(P)42(olycystic kidney disease; 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