References
1.
2.
3.
4.
5.
Wang J, et al. (2011) Further study of genetic association between the TNXB locus and schizophrenia. Psychiatric genetics 21(4):216.
Sullivan KE (1998) Complement deficiency and autoimmunity. Current opinion in pediatrics
10(6):600-606.
Gabrielsson BG, et al. (2003) High expression of complement components in omental adipose tissue in obese men. Obesity research 11(6):699-708.
Agrawal A, et al. (2011) A genome-wide association study of DSM-IV cannabis dependence.
Addiction biology 16(3):514-518.
Healy BC, et al. (2010) HLA B*44: protective effects in MS susceptibility and MRI outcome
6.
7.
8. measures. Neurology 75(7):634-640.
Carter CJ (2009) Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii.
Schizophrenia bulletin 35(6):1163-1182.
International Schizophrenia C, et al. (2009) Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460(7256):748-752.
Aberg KA, et al. (2013) A comprehensive family-based replication study of schizophrenia genes.
JAMA psychiatry 70(6):573-581.
9. Clop A, et al. (2013) An in-depth characterization of the major psoriasis susceptibility locus identifies candidate susceptibility alleles within an HLA-C enhancer element. PloS one
8(8):e71690.
10. Takata A, et al. (2013) A population-specific uncommon variant in GRIN3A associated with schizophrenia. Biological psychiatry 73(6):532-539.
11. Wassink TH, Nopoulos P, Pietila J, Crowe RR, & Andreasen NC (2003) NOTCH4 and the frontal lobe in schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics :
the official publication of the International Society of Psychiatric Genetics 118B(1):1-7.
12. Wei J & Hemmings GP (2000) The NOTCH4 locus is associated with susceptibility to schizophrenia. Nature genetics 25(4):376-377.
13. Luo X, et al. (2004) NOTCH4 gene haplotype is associated with schizophrenia in African
Americans. Biological psychiatry 55(2):112-117.
14. Shibata N, et al. (2007) Genetic association between Notch4 polymorphisms and Alzheimer's disease in the Japanese population. The journals of gerontology. Series A, Biological sciences and
medical sciences 62(4):350-351.
15. Swaminathan S, et al. (2012) Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. PloS one
7(12):e50640.
16. Nakatani N, et al. (2006) Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation. Human
molecular genetics 15(12):1949-1962.
17. Hamza TH, et al. (2010) Common genetic variation in the HLA region is associated with lateonset sporadic Parkinson's disease. Nature genetics 42(9):781-785.
18. Deng T, et al. (2013) Class II major histocompatibility complex plays an essential role in obesityinduced adipose inflammation. Cell metabolism 17(3):411-422.
19. Quiroga I, et al. (2009) Association study of MICA and MICB in Alzheimer's disease. Tissue
antigens 74(3):241-243.
20. Havik B, et al. (2011) The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia. Biological psychiatry 70(1):35-42.

21. International Multiple Sclerosis Genetics C, et al. (2007) Risk alleles for multiple sclerosis identified by a genomewide study. The New England journal of medicine 357(9):851-862.
22. Grant A, Fathalli F, Rouleau G, Joober R, & Flores C (2012) Association between schizophrenia and genetic variation in DCC: a case-control study. Schizophrenia research 137(1-3):26-31.
23. Zhang C, Gao J, Zhang H, Sun L, & Peng G (2012) Robo2--slit and Dcc--netrin1 coordinate neuron axonal pathfinding within the embryonic axon tracts. The Journal of neuroscience : the official
journal of the Society for Neuroscience 32(36):12589-12602.
24. Terracciano A, et al. (2011) Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking. Translational psychiatry
1:e49.
25. Cummings AC, et al. (2012) Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene. Annals of human genetics 76(5):342-351.
26. Lesch KP, et al. (2008) Molecular genetics of adult ADHD: converging evidence from genomewide association and extended pedigree linkage studies. Journal of neural transmission
115(11):1573-1585.
27. Luchetti S, Bossers K, Frajese GV, & Swaab DF (2010) Neurosteroid biosynthetic pathway changes in substantia nigra and caudate nucleus in Parkinson's disease. Brain pathology
20(5):945-951.
28. Zou F, et al. (2013) Different functions of HIPK2 and CtBP2 in traumatic brain injury. Journal of
molecular neuroscience : MN 49(2):395-408.
29. Zhao Z, et al. (2013) Association study of 167 candidate genes for schizophrenia selected by a multi-domain evidence-based prioritization algorithm and neurodevelopmental hypothesis. PloS
one 8(7):e67776.
30. Xiang B, et al. (2012) [Genome-wide association study with memory measures as a quantitative trait locus for schizophrenia]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue
zazhi = Chinese journal of medical genetics 29(3):255-259.
31. Fallin MD, et al. (2010) Fine mapping of the chromosome 10q11-q21 linkage region in
Alzheimer's disease cases and controls. Neurogenetics 11(3):335-348.
32. Lalonde R & Strazielle C (2008) Discrimination learning in Rora(sg) and Grid2(ho) mutant mice.
Neurobiology of learning and memory 90(2):472-474.
33. Sarachana T & Hu VW (2013) Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder. Molecular
autism 4(1):14.
34. Logue MW, et al. (2013) A genome-wide association study of post-traumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus.
Molecular psychiatry 18(8):937-942.
35. Terracciano A, et al. (2010) Genome-wide association scan of trait depression. Biological
psychiatry 68(9):811-817.
36. Le-Niculescu H, et al. (2009) Convergent functional genomics of genome-wide association data for bipolar disorder: comprehensive identification of candidate genes, pathways and mechanisms. American journal of medical genetics. Part B, Neuropsychiatric genetics : the
official publication of the International Society of Psychiatric Genetics 150B(2):155-181.
37. Garriock HA, et al. (2010) A genomewide association study of citalopram response in major depressive disorder. Biological psychiatry 67(2):133-138.
38. Svensson AI (2010) The aromatase inhibitor 1,4,6-androstatriene-3,17-dione (ATD) reduces disinhibitory behavior in intact adult male rats treated with a high dose of testosterone.
Behavioural brain research 206(2):216-222.

39. Edwards TL, et al. (2012) HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of
Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes. American journal of epidemiology 175(1):11-21.
40. Bayless DW, Darling JS, & Daniel JM (2013) Mechanisms by which neonatal testosterone exposure mediates sex differences in impulsivity in prepubertal rats. Hormones and behavior
64(5):764-769.
41. Morel N (2003) Neurotransmitter release: the dark side of the vacuolar-H+ATPase. Biology of
the cell / under the auspices of the European Cell Biology Organization 95(7):453-457.
42. Medina AE (2011) Therapeutic utility of phosphodiesterase type I inhibitors in neurological conditions. Frontiers in neuroscience 5:21.
43. Morton DB, Clemens-Grisham R, Hazelett DJ, & Vermehren-Schmaedick A (2010) Infertility and male mating behavior deficits associated with Pde1c in Drosophila melanogaster. Genetics
186(1):159-165.
44. De Crescenzo V, et al. (2012) Type 1 ryanodine receptor knock-in mutation causing central core disease of skeletal muscle also displays a neuronal phenotype. Proceedings of the National
Academy of Sciences of the United States of America 109(2):610-615.
45. Adasme T, et al. (2011) Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation. Proceedings of the National
Academy of Sciences of the United States of America 108(7):3029-3034.
46. Dabertrand F, Nelson MT, & Brayden JE (2013) Ryanodine receptors, calcium signaling, and regulation of vascular tone in the cerebral parenchymal microcirculation. Microcirculation
20(4):307-316.
47. Matsuo N, et al. (2009) Comprehensive behavioral phenotyping of ryanodine receptor type 3
(RyR3) knockout mice: decreased social contact duration in two social interaction tests. Frontiers
in behavioral neuroscience 3:3.
48. Galeotti N, Quattrone A, Vivoli E, Bartolini A, & Ghelardini C (2008) Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.
Neuroscience 153(3):814-822.
49. Kouzu Y, Moriya T, Takeshima H, Yoshioka T, & Shibata S (2000) Mutant mice lacking ryanodine receptor type 3 exhibit deficits of contextual fear conditioning and activation of calcium/calmodulin-dependent protein kinase II in the hippocampus. Brain research. Molecular
brain research 76(1):142-150.
50. Stephens SH, et al. (2012) Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia. Psychiatric genetics 22(1):1-14.
51. Smith JD, Meehan MH, Crean J, & McCann A (2011) Alpha T-catenin (CTNNA3): a gene in the hand is worth two in the nest. Cellular and molecular life sciences : CMLS 68(15):2493-2498.
52. Berndt SI, et al. (2013) Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature genetics 45(5):501-512.
53. Kim WS, Weickert CS, & Garner B (2008) Role of ATP-binding cassette transporters in brain lipid transport and neurological disease. Journal of neurochemistry 104(5):1145-1166.
54. Abuznait AH & Kaddoumi A (2012) Role of ABC transporters in the pathogenesis of Alzheimer's disease. ACS chemical neuroscience 3(11):820-831.
55. Tournier N, et al. (2010) Interaction of drugs of abuse and maintenance treatments with human
P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale
Neuropsychopharmacologicum 13(7):905-915.

56. Wilker S, Elbert T, & Kolassa IT (2013) The downside of strong emotional memories: How human memory-related genes influence the risk for posttraumatic stress disorder - A selective review.
Neurobiology of learning and memory.
57. Carroll LS, et al. (2010) Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha. Molecular psychiatry 15(11):1101-1111.
58. Rodd ZA, et al. (2008) Differential gene expression in the nucleus accumbens with ethanol selfadministration in inbred alcohol-preferring rats. Pharmacology, biochemistry, and behavior
89(4):481-498.
59. Melen E, et al. (2010) Analyses of shared genetic factors between asthma and obesity in children. The Journal of allergy and clinical immunology 126(3):631-637 e631-638.
60. Girardin F (2006) Membrane transporter proteins: a challenge for CNS drug development.
Dialogues in clinical neuroscience 8(3):311-321.
61. Tropeano M, et al. (2013) Male-biased autosomal effect of 16p13.11 copy number variation in neurodevelopmental disorders. PloS one 8(4):e61365.
62. Wang KS, Liu X, Zhang Q, Aragam N, & Pan Y (2011) Genome-wide association analysis of age at onset in schizophrenia in a European-American sample. American journal of medical genetics.
Part B, Neuropsychiatric genetics : the official publication of the International Society of
Psychiatric Genetics 156B(6):671-680.
63. Quezada-Calvillo R, et al. (2007) Luminal substrate "brake" on mucosal maltase-glucoamylase activity regulates total rate of starch digestion to glucose. Journal of pediatric gastroenterology
and nutrition 45(1):32-43.
64. Williams S, Bateman A, & O'Kelly I (2013) Altered expression of two-pore domain potassium
(K2P) channels in cancer. PloS one 8(10):e74589.
65. Bittner S, et al. (2010) Upregulation of K2P5.1 potassium channels in multiple sclerosis. Annals of
neurology 68(1):58-69.
66. Folsom TD & Fatemi SH (2013) The involvement of Reelin in neurodevelopmental disorders.
Neuropharmacology 68:122-135.
67. Iafrati J, Orejarena MJ, Lassalle O, Bouamrane L, & Chavis P (2013) Reelin, an extracellular matrix protein linked to early onset psychiatric diseases, drives postnatal development of the prefrontal cortex via GluN2B-NMDARs and the mTOR pathway. Molecular psychiatry.
68. Laviola G, Ognibene E, Romano E, Adriani W, & Keller F (2009) Gene-environment interaction during early development in the heterozygous reeler mouse: clues for modelling of major neurobehavioral syndromes. Neuroscience and biobehavioral reviews 33(4):560-572.
69. Brust PF, et al. (1993) Human neuronal voltage-dependent calcium channels: studies on subunit structure and role in channel assembly. Neuropharmacology 32(11):1089-1102.
70. Malki K, et al. (2012) Antidepressant-dependent mRNA changes in mouse associated with hippocampal neurogenesis in a mouse model of depression. Pharmacogenetics and genomics
22(11):765-776.
71. Marballi KK, et al. (2014) Global signaling effects of a schizophrenia-associated missense mutation in neuregulin 1: an exploratory study using whole genome and novel kinome approaches. Journal of neural transmission.
72. Wong ML, Dong C, Maestre-Mesa J, & Licinio J (2008) Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response.
Molecular psychiatry 13(8):800-812.
73. Wefers B, et al. (2012) MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adults. PloS one 7(4):e35035.

74. Zhang Q, et al. (2013) Histone modification mapping in human brain reveals aberrant expression of histone H3 lysine 79 dimethylation in neural tube defects. Neurobiology of disease 54:404-
413.
75. Kahler AK, et al. (2008) Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene. American journal of medical genetics. Part B,
Neuropsychiatric genetics : the official publication of the International Society of Psychiatric
Genetics 147B(7):1089-1100.
76. Nakayama Y, et al. (2012) A putative polypeptide N-acetylgalactosaminyltransferase/Williams-
Beuren syndrome chromosome region 17 (WBSCR17) regulates lamellipodium formation and macropinocytosis. The Journal of biological chemistry 287(38):32222-32235.
77. Merla G, Ucla C, Guipponi M, & Reymond A (2002) Identification of additional transcripts in the
Williams-Beuren syndrome critical region. Human genetics 110(5):429-438.
78. Okamoto N, et al. (2013) Williams-Beuren syndrome with brain malformation and hypertrophic cardiomyopathy. Brain & development.