Sponsored by: Pathology and Laboratory Medicine Grand Rounds Academic Year 2013-2014 “Using Basic T Cell Biology to Create Innovative Approaches To Universal Adoptive Immunotherapy for Cancer” Monday, November 25, 2013 12:00PM-1:00PM Austrian Auditorium, CRB Daniel J. Powell Jr., Ph.D. Research Associate Professor Department of Pathology and & Laboratory Medicine, Perelman SOM Abramson Cancer Center University of Pennsylvania Target Audience This program has been designed for departmental/institutional faculty, fellows and residents in the medical specialties of anatomic pathology, neuropathology, laboratory medicine, and transfusion medicine. Educational Objectives After completing this activity, participants should be able to: Discuss current thinking about topics in pathology and laboratory medicine Recognize biomedical research as it relates to the pathologic basis of disease Distinguish timely topics in modern science and medicine Demonstrate the emerging role of T cells in the control and eradication of human malignancy. Illustrate a basic understanding of the properties of human T lymphocytes that promote or limit the success and safety of adoptive T cell transfer therapy. Describe novel genetic engineering approaches that foster supernatural antitumor killing. Recognize strategies to allow widespread application of successful adoptive immunotherapy for cancer. Accreditation The Perelman School of Medicine at the University of Pennsylvania is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Designation of Credit The Perelman School of Medicine at the University of Pennsylvania designates this live activity for a maximum of 1 AMA PRA Category 1 Credit ™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Acknowledgement of Commercial Support* NONE For more information, please contact Alexis Lerro 215.662.6881 lerroa@uphs.upenn.edu Check your CME online at www.penncmeonline.com Disclosure of Relevant Financial Relationships and Unapproved Uses of Products It is policy at the Perelman School of Medicine at the University of Pennsylvania for individuals who are in a position to control the content of an educational activity to disclose to the learners all relevant financial relationships that they have with any commercial interest that provides products or services that may be relevant to the content of this continuing medical education activity. For this purpose we consider relationships of the person involved in the CME activity to include financial relationships of a spouse or partner. The intent of this policy is not to prevent expert faculty with relevant relationship(s) with commercial interest(s) from involvement in CME, but rather to ensure that Penn CME-certified activities promote quality and safety, are effective in improving medical practice, are based on valid content, and are independent of control from commercial interests and free of commercial bias. Peer review of all content was conducted for all faculty presentations whose disclosure information provided to the Penn Office of CME was found to contain relationships that created a conflict of interest relative to the topic of their presentation. In addition, all faculty were instructed to provide balanced, scientifically rigorous and evidence-based presentations. The staff in the Office of CME at the Perelman School of Medicine at the University of Pennsylvania, Mila Kostic, Director of CME and the peer reviewer Zalman Agus, MD, Associate Dean for CME, have disclosed that they have no relevant financial relationships with any commercial interests related to the content of this educational activity. The following individuals have disclosed that they have no relevant financial relationships with any commercial interests related to the content of this educational activity: PLANNING COMMITTEE MEMBER NAME TAKU KAMBAYASHI,MD, PHD KATHLEEN MONTONE, MD PRESENTER NAME DANIEL J. POWELL JR., PHD The following individuals have reported the listed relevant financial relationships with commercial interests related to the content of this educational activity. PLANNING COMMITTEE MEMBER NAME NAME OF COMMERCIAL INTEREST RELATIONSHIP WARREN S. PEAR, MD, PHD AMGEN & PFIZER STOCK IDEON HEALTH CARE SPOUSE HONORARIUM PRESENTER NAME NAME OF COMMERCIAL INTEREST RELATIONSHIP Relevant Financial Relationships: Financial relationships are those relationships in which the individual benefits by receiving a salary, royalty, intellectual property rights, consulting fee, honoraria, ownership interest (e.g., stocks, stock options or other ownership interest, excluding diversified mutual funds), or other financial benefit. Financial benefits are usually associated with roles such as employment, management position, independent contractor (including contracted research), consulting, speaking and teaching, membership on advisory committees or review panels, board membership, and other activities from which remuneration is received or expected DISCLOSURE OF UNAPPROVED USES OF PRODUCTS PRESENTER NAME PRODUCT INVESTIGATIONAL AND/OR OFF-LABEL USE