Maron, Hettema, Shlik
1
Supplementary Table 1. List of studied candidate genes in panic disorder
Gene information
Symbol
Name
Chromosome 1
ADORA3
adenosine A3 receptor
LEPR
leptin receptor
SLC1A7
solute carrier family 1 (glutamate
transporter), member 7
SLC6A9
solute carrier family 6 (neurotransmitter
transporter, glycine), member 9
HCRTR1
hypocretin (orexin) receptor 1
GRIK3
glutamate receptor, ionotropic, kainate 3
NSUN4
NOL1/NOP2/Sun domain family, member 4
FAAH
fatty acid amide hydrolase
OPRD1
opioid receptor, delta 1
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
HTR6
5-hydroxytryptamine (serotonin) receptor 6
NPPA
natriuretic peptide precursor A
NPPB
natriuretic peptide precursor B
CORT
cortistatin
GABRD
gamma-aminobutyric acid (GABA) A
receptor, delta
GNRHR2
gonadotropin-releasing hormone receptor 2
NGFB
nerve growth factor (beta polypeptide)
S100A10
S100 calcium binding protein A10
CHRNB2
cholinergic receptor, nicotinic, beta 2
NTRK1
neurotrophic tyrosine kinase receptor type 1
NPR1
natriuretic peptide receptor A/guanylate
cyclase A
RGS7
regulator of G-protein signaling 7
ASTN
astrotactin 1
RGS2
regulator of G-protein signaling 2
IL-10
interleukin 10
PIGR
polymeric immunoglobulin receptor
AVPR1B
arginine vasopressin receptor 1B
IL-20
interleukin 20
IL-24
interleukin 24
ADORA1
adenosine A1 receptor
FAIM3
Fas apoptotic inhibitory molecule 3
IKBKE
inhibitor of kappa light polypeptide gene
enhancer in B-cells, kinase epsilon
RASSF5
Ras association (RalGDS/AF-6) domain
family 5
SRGAP2
SLIT-ROBO Rho GTP activating protein 2
CNTN2
contactin 2
IL-19
interleukin 19
DISC1
disrupted in schizophrenia 1
AGT
angiotensinogen
EPHX1
epoxide hydrolase 1, microsomal
ACTN2
actinin, alpha 2
CHRM3
cholinergic receptor, muscarinic 3
Chromosome 2
SLC1A4
solute carrier family 1 (glutamate/neutral
amino acid transporter), member 4
NRXN1
neurexin 1
CRIPT
cysteine-rich PDZ-binding protein
LHCGR
luteinizing hormone/choriogonadotropin
receptor
Studied polymorphisms
Location
Total
References
1p13.2
1p31
1p32.3
3
7
3
2
2
2
1p33
2
2
1p33
1p34-p33
1p34
1p35-p34
1p36-p34.3
1p36.3-p34.3
1p36-p35
1p36.21
1p36.2
1p36.22
1p36.3
1
2
1
1
3
3
2
2
2
2
1
2
2
2
2
2, 41
2
2
2
2
2
2
1q12
1p13.1
1q21
1q21.3
1q21-q22
1q21-q22
1
2
5
2
3
1
2
2
6
2
2
2
1q23.1
1q25.2
1q31
1q31-q32
1q31-q41
1q32
1q32
1q32
1q32.1
1q32.1
1q32.1
7
3
6
9
1
7
6
5
1
1
1
4
2
5, 27
94
94
12
94
94
87
94
94
1q32.1
2
94
1q32.1
1q32.1
1q32.2
1q42.1
1q42-q43
1q42.1
1q42-q43
1q43
1
3
9
1
4
13
2
3
94
2
94
2
2, 50
6
2
2
2p15-p13
3
2
2p16.3
2p21
2p21
2
2
3
2
2
2
Maron, Hettema, Shlik
UCN
PREB
NTSR2
TACR1
POMC
DBI
NPPC
GAD1
CHRNA1
NEUROD1
RAPGEF4
urocortin
prolactin regulatory element binding
neurotensin receptor 2
tachykinin receptor 1
proopiomelanocortin
diazepam binding inhibitor
natriuretic peptide precursor C
glutamate decarboxylase 1
cholinergic receptor, nicotinic, alpha 1
neurogenic differentiation 1
Rap guanine nucleotide exchange factor
(GEF) 4
INPP1
inositol polyphosphate-1-phosphatase
CHRND
cholinergic receptor, nicotinic, delta
CHRNG
cholinergic receptor, nicotinic, gamma
PLCD4
phospholipase C, delta 4
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
Chromosome 3
GABRR3
gamma-aminobutyric acid (GABA) receptor,
rho 3
HTR1F
5-hydroxytryptamine (serotonin) receptor 1F
GRM2
glutamate receptor, metabotropic 2
VIPR1
vasoactive intestinal peptide receptor 1
CCK
cholecystokinin
PLCD1
SLC6A1
phospholipase C, delta 1
solute carrier family 6 (neurotransmitter
transporter, GABA), member 1
OXTR
oxytocin receptor
SLC6A11
solute carrier family 6 (neurotransmitter
transporter, GABA), member 11
CAMK1
calcium/calmodulin-dependent protein
kinase I
GHRL
ghrelin/obestatin prepropeptide
GRM7
glutamate receptor, metabotropic 7
CNTN6
contactin 6
CNTN3
contactin 3
DRD3
dopamine receptor D3
SLC15A2
solute carrier family 15 (H+/peptide
transporter), member 2
TRH
thyrotropin-releasing hormone
AGTR1
angiotensin II receptor, type 1
PLD1
phospholipase D1
NLGN1
neuroligin 1
KNG1
kininogen 1
SST
somatostatin
DLG1
discs, large homolog 1
Chromosome 4
GABRA2
gamma-aminobutyric acid (GABA) A
receptor, alpha 2
GABRA4
gamma-aminobutyric acid (GABA) A
receptor, alpha 4
GABRB1
gamma-aminobutyric acid (GABA) A
receptor, beta 1
GABRG1
gamma-aminobutyric acid (GABA) A
receptor, gamma 1
CCKAR
cholecystokinin A receptor
DRD5
dopamine receptor D5
GNRHR
gonadotropin-releasing hormone receptor
EGF
epidermal growth factor
2
2p23-p21
2p23.3
2p25.1
2p13.1
2p23.3
2q12-q21
2q24
2q31
2q24-q32
2q32
2q31-q32
2
2
2
9
9
7
1
8
3
3
2
2
2
2
2, 8
2, 41
2, 25
2
2, 28
2
2
2
2q32
2q33-q34
2q33-q34
2q35
2q36.3-q37.1
2
1
1
2
2
2
2
2
2
2
3q11.2
3
2
3p12
3p21.3-p21.
3p22
3p22-p21.3
3
1
3
7
3p22-p21.3
3p25-p24
1
22
2
2
2
2, 41, 45, 57, 71,
74, 80, 86
2
2, 7
3p25
3p25.3
3
2
2
2
3p25.3
2
2
3p26-p25
3p26.1-p25.1
3p26-p25
3p26
3q13.3
3q13.33
1
5
2
3
5
12
3
2, 23
2
2
2, 41
6
3q13.3-q21
3q21-q25
3q26
3q26.31
3q27
3q28
3q29
3
1
5
4
5
2
3
2
50
2
2
2
2
2
4p12
2
2, 90
4p12
90
4p12
90
4p12
3
2
4p15.1-p15.2
4p16.1
4q21.2
4q25
11
2
2
5
2, 41, 51, 58, 80
2, 41
2
2
Maron, Hettema, Shlik
NPY2R
neuropeptide Y receptor Y2
NPY1R
neuropeptide Y receptor Y1
NPY5R
neuropeptide Y receptor Y5
NR3C2
nuclear receptor subfamily 3, group C, 2
GLRB
glycine receptor, beta
GRIA2
glutamate receptor, ionotropic, AMPA 2
GLRA3
glycine receptor, alpha 3
Chromosome 5
SLC1A3
solute carrier family 1 (glial high affinity
glutamate transporter), member 3
PRLR
prolactin receptor
NPR3
natriuretic peptide receptor C/guanylate
cyclase C
SLC6A3
solute carrier family 6 (neurotransmitter
transporter, dopamine), member 3
CRHBP
corticotropin releasing hormone binding
protein
HTR1A
5-hydroxytryptamine (serotonin) receptor 1A
GDNF
CARTPT
HOMER1
EPB41L4A
glial cell derived neurotrophic factor
CART prepropeptide
homer homolog 1
erythrocyte membrane protein band 4.1 like
4A
NEUROG1
neurogenin 1
ADRA1B
adrenergic, alpha-1B-, receptor
NRG2
neuregulin 2
GRIA1
glutamate receptor, ionotropic, AMPA 1
ADRB2
adrenergic, beta-2-, receptor, surface
GABRG2
gamma-aminobutyric acid (GABA) A
receptor, gamma 2
NR3C1
nuclear receptor subfamily 3, group C,
member 1
HTR4
5-hydroxytryptamine (serotonin) receptor 4
GLRA1
glycine receptor, alpha 1
GABRP
gamma-aminobutyric acid (GABA) A
receptor, pi
GABRA6
gamma-aminobutyric acid (GABA) A
receptor, alpha 6
GABRB2
gamma-aminobutyric acid (GABA) A
receptor, beta 2
GABRA1
gamma-aminobutyric acid (GABA) A
receptor, alpha 1
GRM6
glutamate receptor, metabotropic 6
DRD1
dopamine receptor D1
Chromosome 6
HCRTR2
hypocretin (orexin) receptor 2
GLO1
glyoxalase I
GRM4
glutamate receptor, metabotropic 4
GABBR1
gamma-aminobutyric acid (GABA) B
receptor, 1
PRL
prolactin
HTR1B
5-hydroxytryptamine (serotonin) receptor 1B
GABRR1
gamma-aminobutyric acid (GABA) receptor,
rho 1
GABRR2
gamma-aminobutyric acid (GABA) receptor,
rho 2
SNAP91
synaptosomal-associated protein, 91kDa
homolog
CNR1
cannabinoid receptor 1
3
4q31
4q31.3-q32
4q31.3-q32
4q31.1
4q31.3
4q32-q33
4q33-q34
7
4
5
4
1
2
2
2, 16
16
2, 16
2
2
2
2
5p13
3
2
5p13.2
5p14-p13
3
3
2
2
5p15.3
2
2, 78
5q11.2-q13.3
3
2
5q11.2-q13
9
5p13.1-p12
5q13.2
5q14.2
5q22.2
4
3
3
28
2, 5, 41, 54, 56,
95
2
2
2
6
5q23-q31
5q23-q32
5q23-q33
5q31.1
5q31-q32
5q31.1-q33.1
2
2
3
3
2
2
2
2
2
2
2
2, 90
5q31.3
2
2
5q31-q33
5q32
5q33-q34
4
3
5
2
2
2
5q34
3
2, 23
5q34
2
2
5q34-q35
2
2, 90
5q35
5q35.1
3
10
2
2, 41
6p12
6p21.3-p21.1
6p21.3
6p21.31
3
15
1
5
2
8, 34
2
2, 73
6p22.2-p21.3
6q13
6q13-q16.3
2
12
4
2
2, 41, 75
2
6q13-q16.3
3
2
6q14.2
1
2
6q14-q15
3
2
Maron, Hettema, Shlik
HTR1E
5-hydroxytryptamine (serotonin) receptor 1E
MCHR2
melanin-concentrating hormone receptor 2
GRIK2
glutamate receptor, ionotropic, kainate 2
ALDH5A1
aldehyde dehydrogenase 5 family, A1
OPRM1
opioid receptor, mu 1
VIP
vasoactive intestinal peptide
ESR1
estrogen receptor 1
Chromosome 7
EGFR
epidermal growth factor receptor
DDC
dopa decarboxylase
NPSR1
neuropeptide S receptor 1
GHRHR
growth hormone releasing hormone
receptor
ADCYAP1R adenylate cyclase activating polypeptide 1
1
receptor type I
CRHR2
corticotropin releasing hormone receptor 2
NPY
neuropeptide Y
INHBA
inhibin, beta A
HOXA1
homeobox A1
AUTS2
autism susceptibility candidate 2
ELN
elastin
MAGI2
membrane associated guanylate kinase, 2
RELN
reelin
ABCB1
ATP-binding cassette, sub-family B
(MDR/TAP), member 1
AKAP9
A kinase (PRKA) anchor protein (yotiao) 9
TAC1
tachykinin, precursor 1
NGFR
nerve growth factor receptor
ACHE
acetylcholinesterase
CPSF4
cleavage and polyadenylation specific factor
4
PIK3CG
phosphoinositide-3-kinase, catalytic,
gamma polypeptide
GRM8
glutamate receptor, metabotropic 8
GRM9
glutamate receptor, metabotropic 9
GRM11
glutamate receptor, metabotropic 11
GRM3
glutamate receptor, metabotropic 3
GRM10
glutamate receptor, metabotropic 10
NRCAM
neuronal cell adhesion molecule
LEP
leptin
CHRM2
cholinergic receptor, muscarinic 2
PTN
pleiotrophin
CNTNAP2
contactin associated protein 2
NOS3
nitric oxide synthase 3 (endothelial cell)
HTR5A
5-hydroxytryptamine (serotonin) receptor 5A
VIPR2
vasoactive intestinal peptide receptor 2
Chromosome 8
CHRNA6
cholinergic receptor, nicotinic, alpha 6
CHRNB3
cholinergic receptor, nicotinic, beta 3
OPRK1
opioid receptor, kappa 1
NRG1
neuregulin 1
GNRH1
gonadotropin-releasing hormone 1
GSR
glutathione reductase
CHRNA2
cholinergic receptor, nicotinic, alpha 2
LYN
v-yes-1 Yamaguchi sarcoma viral related
oncogene homolog
CRH
corticotropin releasing hormone
ADRA1A
adrenergic, alpha-1A-, receptor
SDC2
syndecan 2
TRHR
thyrotropin-releasing hormone receptor
6q14-q15
6q16
6q16.3-q21
6p22.2-p22.3
6q24-q25
6q25
6q25.1
3
3
3
3
8
3
5
2
2
2
2
2, 41
2
2, 66
7p12
7p12.2
7p14.3
7p14
2
2
1
1
2
2
18
2
7p14
2
2
7p15.1
7p15.1
7p15-p13
7p15.3
7q11.22
7q11.23
7q21
7q22
7q21.1
24
6
3
3
1
3
1
2
1
2, 12, 29
2, 16, 33
2
2
2
60
2
2
2
7q21-q22
7q21-q22
7q21-q22
7q22
7q22.1
3
2
3
1
4
2
2
2
2
60
7q22.3
3
2
7q31.3-q32.1
7q31.3-q32.1
7q31.3-q32.1
7q21.1-q21.2
7q31.3-q32.1
7q31.1-q31.2
7q31.3
7q31-q35
7q33-q34
7q35-q36
7q36
7q36.1
7q36.3
1
1
1
3
1
3
3
1
2
2
1
3
4
23
2
2
2
2
2
2
2
2
2
2
2
2
8p11.21
8p11.2
8q11.2
8p12
8p21-p11.2
8p21.1
8p21
8q13
3
1
11
5
3
22
4
3
2
2
2, 41
2
2
6
2
2
8q13
8p21-p11.2
8q22-q23
8q23
12
4
5
3
2, 12
2
2
2
4
Maron, Hettema, Shlik
PENK
proenkephalin
Chromosome 9
CNTFR
ciliary neurotrophic factor receptor
NPR2
natriuretic peptide receptor B/guanylate
cyclase B
SLC1A1
solute carrier family 1 (neuronal/epithelial
high affinity glutamate transporter, system
Xag), member 1
NTRK2
neurotrophic tyrosine kinase receptor type 2
GRIN3A
glutamate receptor, ionotropic, N-methyl-Daspartate 3A
ALAD
aminolevulinate, delta-, dehydratase
ASTN2
astrotactin 2
DBH
dopamine beta-hydroxylase
PTGDS
prostaglandin D2 synthase
Chromosome 10
CREM
cAMP responsive element modulator
GAD2
glutamate decarboxylase 2
NRP1
neuropilin 1
CHAT
choline acetyltransferase
TACR2
tachykinin receptor 2
GDF2
growth differentiation factor 2
PSAP
prosaposin
HTR7
5-hydroxytryptamine (serotonin) receptor 7
NRG3
neuregulin 3
ADRA2A
adrenergic, alpha-2A-, receptor
ADRB1
adrenergic, beta-1-, receptor
Chromosome 11
SLC1A2
solute carrier family 1 (glial high affinity
glutamate transporter), member 2
BDNF
brain-derived neurotrophic factor
SLC17A6
solute carrier family 17 (sodium-dependent
inorganic phosphate cotransporter),
member 6
CALCA
calcitonin-related polypeptide alpha
CALCB
calcitonin-related polypeptide beta
SLC6A5
solute carrier family 6 (neurotransmitter
transporter, glycine), member 5
TPH1
tryptophan hydroxylase 1
CCKBR
cholecystokinin B receptor
DRD4
dopamine receptor D4
TH
tyrosine hydroxylase
CNTF
ciliary neurotrophic factor
CHRM1
cholinergic receptor, muscarinic 1
NRXN2
neurexin 2
GRM5
glutamate receptor, metabotropic 5
GAL
galanin prepropeptide
DLG2
discs, large homolog 2
CNTN5
contactin 5
GRIA4
glutamate receptor, ionotrophic, AMPA 4
PGR
progesterone receptor
GRIK4
glutamate receptor, ionotropic, kainate 4
DRD2
dopamine receptor D2
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
NCAM1
neural cell adhesion molecule 1
HTR3A
5-hydroxytryptamine (serotonin) receptor 3A
Chromosome 12
GRIN2B
glutamate receptor, ionotropic, N-methyl D-
5
8q23-q24
4
2, 41
9p13
9p21-p12
2
3
2
2
9p24
5
2
9q22.1
9q31.1
2
5
2
2
9q33.1
9q33.1
9q34
9q34.2-q34.3
18
5
3
10
6
2
2
6
10p11.21
10p11.23
10p12
10q11.2
10q11-q21
10q11.22
10q21-q22
10q21-q24
10q22-q23
10q24-q26
10q24-q26
8
16
4
3
3
2
19
2
2
2
1
52, 59
2, 28
2
2
2
2
6
2
2
2, 79
2
11p13-p12
2
2
11p13
11p14.3
8
2
2, 39, 49
2
11p15.2
11p15.2
11p15.2p15.1
11p15.3-p14
3
3
3
2
2
2
7
11p15.4
11
11p15.5
11p15.5
11q12.2
11q13
11q13
11q13-q13.4
11q13.2
11q14.1
11q21-q22.2
11q22
11q22-q23
11q22.3
11q23
11q23.1
11q23.1
11q23.1
8
2
3
1
4
2
7
1
2
2
1
2
13
4
5
5
2, 10, 26, 41, 43,
70, 83
2, 41, 45, 68, 69,
74, 80, 93
41, 78
41
2
2
2
2
2, 19
2
2
2
46
2
2, 41
2
2
2, 15, 41
12p12
5
2
Maron, Hettema, Shlik
NTF3
GNB3
SLC6A12
SLC6A13
CNTN1
ACCN2
SHMT2
NEUROD4
TAC3
GRIP1
AVPR1A
NTS
TPH2
PAH
PMCH
P2RX7
CaMKKb
OASL
NOS1
aspartate 2B
neurotrophin 3
guanine nucleotide binding protein (G
protein), beta polypeptide 3
solute carrier family 6 (neurotransmitter
transporter, betaine/GABA), member 12
solute carrier family 6 (neurotransmitter
transporter, GABA), member 13
contactin 1
amiloride-sensitive cation channel 2,
neuronal
serine hydroxymethyltransferase 2
neurogenic differentiation 4
tachykinin, precursor 3
glutamate receptor interacting protein 1
arginine vasopressin receptor 1A
neurotensin
tryptophan hydroxylase 2
phenylalanine hydroxylase
pro-melanin-concentrating hormone
purinergic receptor P2X, ligand-gated ion
channel, 7
calcium/calmodulin-dependent protein
kinase kinase 2, beta
2'-5'-oligoadenylate synthetase-like
nitric oxide synthase 1 (neuronal)
P2RX4
purinergic receptor P2X, ligand-gated ion
channel, 4
Chromosome 13
NBEA
neurobeachin
HTR2A
5-hydroxytryptamine (serotonin) receptor 2A
DAOA/G30
D-amino acid oxidase activator/ putative
protein LG30
Chromosome 14
SSTR1
somatostatin receptor 1
GMFB
glia maturation factor, beta
NRXN3
neurexin 3
SERPINA6
serpin peptidase inhibitor, clade A, 6
BDKRB1
bradykinin receptor B1
BDKRB2
bradykinin receptor B2
Chromosome 15
ATP10A
ATPase, class V, type 10A
GABRA5
gamma-aminobutyric acid (GABA) A
receptor, alpha 5
GABRB3
gamma-aminobutyric acid (GABA) A
receptor, beta 3
GABRG3
gamma-aminobutyric acid (GABA) A
receptor, gamma 3
UBE3A
ubiquitin protein ligase E3A
CHRNA7
cholinergic receptor, nicotinic, alpha 7
SNAP23
synaptosomal-associated protein, 23kDa
CHRNA5
cholinergic receptor, nicotinic, alpha 5
CHRNB4
cholinergic receptor, nicotinic, beta 4
HOMER2
homer homolog 2
NTRK3
neurotrophic tyrosine kinase receptor type 3
CHRM5
cholinergic receptor, muscarinic 5
Chromosome 16
GRIN2A
glutamate receptor, ionotropic, N-methyl D-
6
12p13
12p13
3
2
2
2
12p13
2
2
12p13.3
3
2
12q11-q12
12q12
3
7
2
13
12q12-q14
12q13.2
12q13-q21
12q14.3
12q14-q15
12q21
12q21.1
12q22-q24.2
12q23-q24
12q24
1
3
3
3
7
3
5
2
3
12
2
2
2
2
2, 12
2
1, 24, 32
2
2
22
12q24.2
2
22
12q24.2
12q24.2q24.31
12q24.32
5
2
22
2
6
22
13q13
13q14-q21
2
20
13q34
5
2
2, 10, 20, 41, 47,
56, 70
38
14q13
14q22.2
14q31
14q32.1
14q32.1-q32
14q32.1-q32
2
3
4
4
3
4
2
2
2
2
2
2
15q11.2
15q11.2-q12
3
1
2
2, 90
15q11.2-q12
2
2, 90
15q11.2-q12
4
2
15q11-q13
15q14
15q15.1
15q24
15q24
15q24.3
15q25
15q26
4
2
1
2
2
3
4
3
2
2
2
2
2
2
63
2
16p13.2
3
2
Maron, Hettema, Shlik
aspartate 2A
tuberous sclerosis 2
solute carrier family 6 (neurotransmitter
transporter, noradrenalin), member 2
PLCG2
phospholipase C, gamma 2
(phosphatidylinositol-specific)
Chromosome 17
SHMT1
serine hydroxymethyltransferase 1
ADORA2B
adenosine A2b receptor
NLGN2
neuroligin 2
PLD2
phospholipase D2
CHRNB1
cholinergic receptor, nicotinic, beta 1
SHBG
sex hormone-binding globulin
CHRNE
cholinergic receptor, nicotinic, epsilon
NOS2P1
nitric oxide synthase 2 pseudogene 1
SLC6A4
solute carrier family 6 (neurotransmitter
transporter, serotonin), member 4
TSC2
SLC6A2
NOS2A
PPP1R1B
nitric oxide synthase 2, inducible
protein phosphatase 1, regulatory (inhibitor)
subunit 1B
NEUROD2
neurogenic differentiation 2
CRHR1
corticotropin releasing hormone receptor 1
CNTNAP1
contactin associated protein 1
NSF
N-ethylmaleimide-sensitive factor
PNMT
phenylethanolamine N-methyltransferase
PYY
peptide YY
DYNLL2
dynein, light chain, LC8-type 2
PRKCA
protein kinase C, alpha
ACE I
angiotensin I converting enzyme 1
SSTR2
somatostatin receptor 2
AANAT
arylalkylamine N-acetyltransferase
GALR2
galanin receptor 2
Chromosome 18
ADCYAP1
adenylate cyclase activating polypeptide 1
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
GRP
gastrin-releasing peptide
NGFR
nerve growth factor receptor
GALR1
galanin receptor 1
Chromosome 19
SLC17A7
solute carrier family 17 (sodium-dependent
inorganic phosphate cotransporter),
member 7
SCN1B
sodium channel, voltage-gated, type I, beta
SLC1A6
carrier family 1 (high affinity
aspartate/glutamate transporter), member 6
ApoE
apolipoprotein E
GRIK5
glutamate receptor, ionotropic, kainate 5
GRLF1
glucocorticoid receptor DNA binding factor 1
NTF5
Neurotrophin 5
Chromosome 20
SSTR4
somatostatin receptor 4
PLCB4
phospholipase C, beta 4
PDYN
prodynorphin
SNAP25
synaptosomal-associated protein, 25kDa
ADRA1D
adrenergic, alpha-1D-, receptor
AVP
arginine vasopressin
GNRH2
gonadotropin-releasing hormone 2
OXT
oxytocin, prepropeptide
7
16p13.3
16q12.2
1
9
2
42, 62
16q24.1
1
2
17p11.2
17p12-p11.2
17p13.1
17p13.1
17p13.1
17p13-p12
17p13-p12
17q11.1
17q11.1-q12
3
2
1
1
1
1
1
2
19
17q11.2-q12
17q12
4
1
2
2
2
2
2
2
2
1
2, 5, 26, 35, 36,
43, 44, 81, 88,
89, 92
2
2
17q12
17q12-q22
17q21
17q21
17q21-q22
17q21.1
17q22
17q22-q23.2
17q23.3
17q24
17q25
17q25.3
1
23
4
1
2
1
7
2
25
2
1
1
2
2, 8, 12
2
2
2
2
6
2
14, 17, 48, 50
2
2
2
18p11
18q11.2
18q21.1q21.32
17q21-q22
18q23
3
23
7
2
6
2, 8
3
3
2
2
19q13
2
2
19q13.1
19p13.12
5
2
6
2
19q13.2
19q13.2
19q13.3
19q13.3
1
2
2
1
37
2
2
2
20p11.2
20p12
20p12
20p12-p11.2
20p13
20p13
20p13
20p13
3
3
3
3
1
13
2
1
2
2
2
2
2
2, 12
2
2
Maron, Hettema, Shlik
GHRH
DLGAP4
growth hormone releasing hormone
discs, large (Drosophila) homologassociated protein 4
ADA
adenosine deaminase
PLCG1
phospholipase C, gamma 1
NTSR1
neurotensin receptor 1
ORL1
opiate receptor-like 1
CHRNA4
cholinergic receptor, nicotinic, alpha 4
Chromosome 21
NCAM2
neural cell adhesion molecule 2
GRIK1
glutamate receptor, ionotropic, kainate 1
ABCG1
ATP-binding cassette, sub-family G
(WHITE), member 1
PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
S100B
S100 calcium binding protein B
Chromosome 22
COMT
catechol-O-methyltransferase
SNAP29
synaptosomal-associated protein, 29kDa
ADORA2A
adenosine A2a receptor
TFIP11
tuftelin interacting protein 11
ADRBK2
adrenergic, beta, receptor kinase 2
LIF
leukemia inhibitory factor
OSM
oncostatin M
GALR3
galanin receptor 3
SSTR3
somatostatin receptor 3
PICK1
protein interacting with PRKCA 1
TSPO
translocator protein
Chromosome X
MAO-B
monoamine oxidase B
SYNI
synapsin I
MAO-A
monoamine oxidase A
GLRA2
GRPR
glycine receptor, alpha 2
gastrin-releasing peptide receptor
DLG3
HTR2C
GRIA3
GABRA3
discs, large homolog 3
5-hydroxytryptamine (serotonin) receptor 2C
glutamate receptor, ionotrophic, AMPA 3
gamma-aminobutyric acid (GABA) A
receptor, alpha 3
gamma-aminobutyric acid (GABA) A
receptor, epsilon
gamma-aminobutyric acid (GABA) receptor,
theta
L1 cell adhesion molecule
arginine vasopressin receptor 2
GABRE
GABRQ
L1CAM
AVPR2
8
20q11.2
20q11.23
3
1
2
2
20q12-q13.1
20q12-q13.1
20q13
20q13.33
20q13.2-q13
4
6
2
1
3
2
2
2
23
91
21q21.1
21q22.11
21q22.3
4
3
2
2
2
82
21q22.3
21q22.3
2
2
2
2
22q11.2
33
22q11.21
22q11.23
22q12.1
22q12.1
22q12.2
22q12.2
22q13.1
22q13.1
22q13.1
22q13.31
1
6
2
2
1
2
1
2
1
1
5, 11, 30, 44, 53,
64, 67, 85, 96
2
2, 40, 55, 69, 87
2
2
2
2
2
2
2
31
Xp11.23
Xp11.23
Xp11.4
1
3
4
Xp22.1-p21.3
Xp22.2p22.13
Xq13.1
Xq24
Xq25-q26
Xq28
2
10
2
2
2, 43, 44, 61, 76,
84
2
5, 8
1
7
3
2
2
2, 41, 56, 72, 77
2
90
Xq28
3
2
Xq28
4
2
Xq28
Xq28
2
1
2
2
Maron, Hettema, Shlik
9
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Knowles JA. Investigation of polymorphisms in the CREM gene in panic disorder. Am J Med
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Maron, Hettema, Shlik 13
53. Domschke K, Freitag CM, Kuhlenbäumer G, Schirmacher A, Sand P, Nyhuis P, Jacob C,
Fritze J, Franke P, Rietschel M, Garritsen HS, Fimmers R, Nöthen MM, Lesch KP, Stögbauer
F, Deckert J. Association of the functional V158M catechol-O-methyl-transferase
polymorphism with panic disorder in women. Int J Neuropsychopharmacol. 2004 Jun;7(2):1838.
54. Rothe C, Gutknecht L, Freitag C, Tauber R, Mössner R, Franke P, Fritze J, Wagner G, Peikert
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