The 8th Sino-US Chemistry Professors Conference
Kunming 2012
Active Cyclopeptides from Medicinal Plants
Ning-Hua Tan
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences,
Kunming 650201, Yunnan, P.R. China
Plant cyclopeptides were defined as cyclic compounds formed mainly with the peptide bonds of 2-37
protein or non-protein amino acids and discovered in higher plants, mainly L-amino acids. Now over 450
cyclopeptides had been discovered from higher plants which belong to 25 families, 65 genera and 120
species, with a range of interesting biological activities including anti-tumor, anti-HIV, anti-bacteria, antimalaria, sedative, anti-platelet, estrogen-like, uterotonic, immunomodulating, immunosuppressive and
inhibiting cyclooxgenase, tyrosinase and trypsin activities. In this presentation, new findings on plant
bioactive cyclopeptides during past five years in my lab will be introduced. It includes 150 cyclopeptides
coving 50 new ones, 30 active ones and 2 leads from 15 medicinal plants. Their anti-tumor and
immunosuppressive activity with the new mechanism will be involved.
Figure or Scheme
This work was supported by the National Natural Science Foundation of China (30725048, 91013002, U1032602), the
National New Drug Innovation Major Project of China (2011ZX09307-002-02), the National Basic Research Program of
China (2009CB522300) and the Fund of Chinese Academy of Sciences (KSCX2-YW-R-177).
References
1.
N.-H. Tan and J. Zhou. Chem. Rev., 2006, 106, 840
2.
W.-Y. Xu, J. Tang, C.-J. Ji, W.-J. He, N.-H. Tan. Chin. Sci. Bull., 2008, 53, 1671
3.
H. Yan, X.-L. Pan, N.-H. Tan, J.-T. Fan, G.-Z. Zeng, H.-J. Han. Eur. J. Med. Chem., 2009, 44, 3425
4.
C. K. Wang, S. H. Hu, J. L. Martin, T. Sjogren, J. Hajdu, L. Bohlin, P. Claeson, U. Goransson, K. J. Rosengren, J. Tang, N.-H. Tan, D. J. Craik. J. Biol.
Chem., 2009, 284, 10672
5.
J. Tang, C. K. Wang, X.-L. Pan, H. Yan, G.-Z. Zeng, W.-Y. Xu, W.-J. He, N. L. Daly, D. J. Craik, N.-H. Tan. Peptides, 2010, 31, 1434
6.
J.-T. Fan, Y.-S. Chen, W.-Y. Xu, L Du, G.-Z. Zeng, Y.-M. Zhang, J. Su, Y. Li, N.-H. Tan. Tetrahedron Lett., 2010, 51, 6810
7.
G. G. L. Yue, J.-T. Fan, J. K. M. Lee, G.-Z. Zeng, T. W. F. Ho, K.-P. Fung, P.-C. Leung, N.-H. Tan, C. B. S. Lau. Br. J. Pharmacol., 2011, 164, 1883
8.
Y. Shen, Q. Luo, H.-M. Xu, G.-Y. Gong, X.-B. Zhou, Y. Sun, X.-F Wu, W. Liu, G.-Z. Zeng, N.-H Tan, Q. Xu. Biochem. Pharmacol., 2011, 82, 260
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J. Han, C.-J. Ji, W.-J. He, Y. Shen, Y. Leng, W.-Y. Xu, J.-T. Fan, G.-Z. Zeng, L.-D. Kong, N.-H. Tan. J. Nat. Prod., 2011, 74, 2571
Ning-Hua Tan（谭宁华）
1997 - present: Professor of Kunming Institute of Botany, CAS
Dec 2008 - Feb 2009: Visiting Professor of University of Wisconsin-Madison, USA
Oct - Nov 2006: Visiting Professor of the University of Queensland, Australia
Apr - Sep 1998: Visiting Scholar of National Cancer Institute, USA
Jan - Feb 1996: Visiting Scholar of BAYER AG, Germany and USA
1993 - 1995: Postdoctoral Fellow of Kunming Institute of Botany, CAS
1990 - 1993: Ph.D., China Pharmaceutical University
1987 - 1990: M.S., China Pharmaceutical University
1980 - 1984: B.S., Guiyang Medical University
Tel: (+) 86 -871-5223800;
E-mail: nhtan@mail.kib.ac.cn
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