Dose
Sr.No
1.
Activity
Animal Model
Extract
Ochratoxin A induced Ethanolic
Immunomodulatory immune suppression 1 (Whole Plant)
Action
(mg/kg)
100
Cyclophosphamide Aquous (Stem) 100
induced
myelosuppression in
mice 2, 3
Cyclophosphamide
induced
myelosuppression in
mice 4
2.
Endocrine Actions
(A)
Hypoglycaemic
Streptozocin
induced diabetes in
mice 5
Normal and
Alloxan induced
diabetes in rabbits 6
Alloxan diabetic
rats 7
50
Aqueous
( 400
Whole
Plant)
Aqueous,Alc 50-100
oholic&
CHCl3
(Leaves)
Alcoholic
100
(Root)
Result
Remarks
Peptide
IL-1 and
TNF
normalise
d
Increased
levels of
WBC
Immunostimulatio
n
Protective
against
myelosupression
(neutrophi
ls)
Reduced Protective
free
against
radical
cyclophos
formation phamide
and
induced
enhanced toxic
bone
effects
marrow
cell
differentia
tion
Reduced Hypoglucose glycaemic
levels
action
Dose
Hypodependent glycaemic
Hypoglyce action
mia
Reduce
Hypoglyca
blood
emic
glucose action
levels
(B)
3.
Hypolipidemic
Effect
HEPATIC
EFFECT
Fasted albino rats 8 Ethanolic
(Stem)
250
30%
Hyporeduction glycaemic
in blood action
sugar
Adrenaline induced Aqueous
hyperglycaemia in (Stem)
rabbits 9
10
Inhibited
adrenaline
induced
hyperglycaemia
Alloxan diabetic
rats 7
Alcoholic
(Root)
100
Alloxan diabetic
rabbits 6
Aqueous,
Alcohlic,
CHCl3
(Leaves)
CCl4 intoxicated
rats 10
Aqueous
(Stem)
Horse serum
injection induced
chronic liver
damage in rats 11
Aqueous
decoction
(Stem)
Antihyperglyc
emic
effect
Decreased Hypolevels of lipidemic
both
Effect
serum and
tissue
cholesterol
,
phospholi
pids, free
fatty acid
50,100,1 No
50,200 significant
effect on
total lipid
levels
100
Reduced Hepatoelevated
serum
protective
liver
enzyme
level to
near
control
levels
100
Improved Hepatokupffer
cell
Protective
function
4.
Anti-infective
Effects
Invitro using
diffusion assay
12
Aqueous,
Ethanolic
and CHCl3
(Strains of E.choli,
Proteus vulgaris, (Stem)
Enterobacter
faecalis ,
Salmonella typhi,
Staphylococcus
aureus, Serratia
marcescens)
Ranikhet disease
virus
Ethanolic
(Stem)
(In vitro) 8
Starins of
Mycobactreium
Tuberculosis 13
5.
ANTIPYRETIC
EFFECT
100
mg/ml
incubati
on 24 h/
37o C
Ethanolic Antibacter
: All
ial activity
organisms
CHCl3: 4
organisms
excluding
Staphycoc
cus aureus
and
Serratia
marcescen
s
Aqueous:
E.choli
50µg/ml Reduction Antiviral
Incubati in viral
activity`
on 48-72 progeny
h/ 37o C
Ether (Aerial Parts)
Inhibition Anti
of invitro tuberculos
growth of is activity
Mycobactr
eium
Tuberculo
sis
Caecal ligation
Decoction
induced abdominal (Powdered
sepsis in rats 14
Stem)
100
Protective Antisepsis
against
activity
caecal
ligation
induced
abdominal
sepsis
Yeast induced
Hexane,
pyrexia (Himalayan CHCl3/
Rabbits) 15
Water
150
0.38Antipyreti
o
0.60 C
c activity
Temperatu
yeast induced
pyrexia (Albino
rats) 16
6.
ANTISTRESS
EFFECT
re
decrease
500
0.3-2 0C Antipyreti
Temperatu c activity
re
reduction
8h resistant stress Alcoholic
induced changes in (Root)
brain(Charles
foaster male rats) 17
100
stress induced
Ethanolic
ulcerization (Male (Root)
rats) 18
100
Normalize CNS
d Brain
dependent
NA,
activity
Dopamine,
5-HT and
5-HIAA
Protective Ulcereffect
protective
against
activity
stress
induced
ulcerizatio
n
Antistress Antistress
action in activity
mouse
swimming
endurance
test on day
8
swimming
endurance test
(Mouse) 19
7.
Soluble
Fraction
(Ethanolic;
Stem)
Ethanolic
(Whole
Plant)
Extract
100
suspensions
(Pet ether.,
Acetone,
Ethanol
,H2O)
a.Carrageen
Aqueous
ANTI(Stem)
INFLAMMAT0RY induced
inflammation in Rat
EFFECTS
b.croton oil induced
inflammation in Rat
a.50
a.
AntiInhibition inflammat
of acute ory
inflammati activity
on
b.20
b.
Inhibition
of chronic
20
inflammati
on
a.Cotton pelletAqueous
induced granuloma (Stem)
a.1250 Reduced
and 500 inflammat
ory
response
b.Formalin induced
arthritis
b.1
Antiinflammat
ory
activity
(Rat Models) 21
Human leukemic Not specified 100mg/ Reduce
Antineopl
cell lines (HL-60,Uml
proliferati astic
937)
on index activity
of human
22
leukemic
(in vitro)
cell lines
Ehrlich ascites
Methanolic 200
64%decre Anticarcinoma
(Stem)
ase in
tumour
cells(Swiss albino)
tumour
activity
developme
nt
(in vivo) 23
8.
ANTINEOPLASTIC
ACTIVITY
9.
Sarcoma
180,heptoma
ANTI-OXIDANT 129(Mouse) 8
EFFECTS
RADIO-PROTEC- Alloxan diabetic
TIVE EFFECTS rats 24, 25
10.
Ethanolic
(Stem)
Aqueous
(Root)
Not
Anti
Antispecified tumourige tumourige
nic
nic
activity activity
2.5-5
Reduced Antioxida
TBARS, nt activity
Ceruloplas
min and
Tocophero
l
Increased
plasma
Glutathion
e, Vit C,
Catalase,
SOD
Aflatoxicosis of
Aqueous
White pekin ducks (Stem)
26
100g(in a) No
An
1L of
toxicity ameliorati
drinking
ng effect
water for b)
1 month) Increased
body
weight
c)
Improved
haematolo
gical
parameters
Mice exposure to Ethanolic
gamma radiation 27 (Stem)
200
Increased Radiosurvival protective
activity
Prevented
body loss
Increased
CFU
counts in
spleen,
Restored
total
lymphocyt
es counts
Mice exposure to Aqueous
gamma radiation 28 extract
5,10 or Increased Radio20
survival protective
time
Improvem
ent of
clinical
signs.
activity