Supplementary Table 2 Muscle strength training: monofactorial intervention studies. Methods Approach Duration Population Number Ex Co Age Sex Effect of training on: Strength Significant No effect effect Knee ext Grip Ref Stability Significant effect Tandem stance, one-legged stance eo Backwards tandem gait; onelegged stance eo (within intervention) Lateral stabilitye Falls Significant effect No effect One-legged stance ec, tandem gait NA NA 1 One-legged stance ec NA NA 2 – NA NA 3 Static posturography, maximum reach, onelegged stance narrow support Functional reach, stance ground ec NA NA 4 NA NA 5 rh 0.53 (0.30-0.91); rr 0.61 (0.39-0.93) – 6 NA NA 7 hr 0.78 (0.64– 0.94); hr adj 0.72 (0.59–0.88)f – – 8 Number 9 No effect Exercise 10m, 3xpw, 1h 37 44 65+ M+ F Dynamic resistance 12w, 3xpw 25 30 65+ M+ F Knee ext/flex – Weighted vest exercises Leg strength 9m, 3xpw, 1h 18a 22 50+ F Dorsiflex 3m, 3xpw, 45 min 28 27 75+ M+ F Hip abd; knee ext; plantarflex Knee ext; plantarflex; hip ext Hip abd; dorsiflex – Leg resistance 10w, 3xpw 50d 50 64+ M+ F Dorsiflex – Whole body training 6m, 3xpd, 1hr 25b 30 68+ M+ F Knee ext/flex; plantarflex Hip; knee; elbow Ankle – Whole body resistance Targeted exercise per subject Quadriceps 25w, 2xpw, 50 min 16m, 3xpd 32c 32 75+ F – Dorsiflex; quadriceps Fall risk score; stance foam eo Balance beams, parallel/(semi) tandem stance, stance on tilt boards Balance and mobility score 180 178 85+ M+ F – Chair stands; grip Tandem stance – 10w, 3xpw 112 110 65+ M+ – Quadriceps NA NA resistance Arm and leg resistance d 12 m, 3xpw 30 30 65+ F M+ F – Quadriceps; grip – Static posturography; (semi) tandem/onelegged stance – of falls Number of falls 10 a White nonsmoking women. bMild strength/balance deficits. cWith osteoporosis, control group did stretch exercises. dFrail. eOn posturography predicted by hip abd strength; lateral path of sway predicted by relative maximum leg power. fFirst fall in those able to move outdoors, hr adj = adjusted for age, sex, vision, previous falls, vision, propriception, strength, reaction time, balance, single-legged stance, tandem gait, stair mobility. Abbreviations: abd, abduction; adj, adjusted; Co, controls; ec, eyes closed; eo, eyes open; Ex, exercisers; ext, extension; F, female; flex, flexion; h, hour; hr, hazard ratio; m, months; M, male; pd, per day; NA, not applicable; pw, per week; rh, relative hazard; rr, relative risk; w, weeks. References 1. Rooks DS et al. (1997) Self-paced resistance training and walking exercise in community-dwelling older adults: effect on neuromotor performance. J Gerontol A Biol Sci Med Sci 52: M161–M168 2. Topp R et al. (1993) The effect of a 12-week dynamic resistance strength training progam on gait verlocity and balance of older adults. Gerontologist 33: 501–506 3. Shaw JM et al. (1998) Weighted vest exercise improves indices of fall risk in older women. J Gerontol A Biol Sci Med Sci 53: M53–M58 4. Wolfson L et al. (1996) Balance and strength training in older adults: intervention gains and Tai Chi maintenance. J Am Geriatr Soc 44: 498– 506 5. Chandler JM et al. (1998) Is lower extremity strength gain associated with improvement in physical performance and disability in frail, community-dwelling elders? Arch Phys Med Rehabil 79: 24–30 6. Buchner DM et al. (1997) The effect of strength and endurance training on gait, balance, fall risk, and health services use in community-living older adults. J Gerontol A Biol Sci Med Sci 52: M218–M224 7. Liu-Ambrose T et al. (2004) Resistance and agility training reduce fall risk in women aged 75-85 with low bone mass: a 6 month randomized, controlled trial. J Am Geriatr Soc 52: 657–665 8. Luukinen H et al. (2007) Pragmatic exercise-oriented prevention of falls among the elderly: a population-based, randomized, controlled trial. Prev Med 44: 265–271 9. Latham NK et al. (2003) A randomized, controlled trial of quadriceps resistance exercise and vitamin D in frail older people: the frailty interventions trial in elderly subjects (FITNESS). J Am Geriatr Soc 51: 291–299 10. Woo J et al. (2007) A randomized controlled trial of Tai Chi and resistance exercise on bone health, muscle strength and balance in community-living elderly people. Age Ageing 36: 262–268