BIOS 4980 Fall 2010 CRN 41659
Instructor:
Contact information:
Office location:
Office hours:
Class meeting times:
Rob Eversole, PhD.
387-5640, e-mail: rob.eversole@wmich.edu
2402 Haenicke Hall
T & TR 11:00 AM-12:00 PM and by appointment
M 1:30-3:50 PM, Fetzer Center Room 1005
Introduction
The 2010 Vaccinology Seminar Series to be held on Mondays from 1:30-3:50PM ET,
September 13 through December 6, 2010. It is anticipated that the lecture will last 1 1/2 hours with a break in the middle and then the remainder of the time will be for questions and answers with the speaker. This lecture series, co-sponsored by Pfizer Inc and
Western Michigan University, will be presented at The Fetzer Center located on the campus of Western Michigan University in Kalamazoo, MI, and will be linked via videoconference to multiple Pfizer sites around the globe and Michigan State University.
Employees and students in Kalamazoo are expected to participate at The Fetzer Center; therefore, it will not be broadcast to any local sites.
Course Information
This course will cover the biological development, immunologic concepts, and methods for vaccines and biopharmaceuticals as well as methods of delivery and administration.
Specific topics include new technologies for vaccine development such as DNA vaccines, recombinant mucosal vaccines, and dendritic cells for antigen delivery, novel adjuvants and methods to increase vaccine stability. Delivery systems for vaccines will include current technologies as well as novel technologies presently under development. The underlying biological roles of the innate and adaptive immune systems will be studied relative to the new types of vaccines and delivery systems. Finally, the process of manufacturing and bringing vaccines to market will be covered including government oversight and licensure.
Each week a different speaker will present a topic in their specific area of expertise.
These speakers have been selected based on their individual outstanding academic and professional achievements in the field of Vaccinology. It is encouraged that local seminar participants attend at The Fetzer Center so they can meet the speakers in person.
Text, Readings, Materials
Slide sets will be forwarded in advance to course attendees, whenever possible. There is no text required for this series but supplemental readings may be provided for certain presentations. The website URL for Vaccinology 2007, 2008 and 2010 is: www.wmich.edu/vaccinology/
Just click on Vaccinology 2007, 2008 or 2010 and most of the talks are presented with both visual on the speakers and their PowerPoint materials. These talks will provide valuable background information for writing the proposal paper in this class.

Supplementary (Suggested) Readings i.
Immunopotentiators in Modern Vaccines by Schijns and O’Hagen ii.
Vaccines, Fourth Edition by Plotkin and Orensteinhttp iii.
Vaccine Protocols,C Second Edition by Robinson, Hudson and Cranage
Objectives
The intention of this course is to introduce students to the study of Vaccinology and to provide current status of the field.
Course Calendar
Date
13-Sep-10
Topic
"Advances in Fish Vaccinology"
Speaker
Phil Klesius, USDA, ARS,
Aquatic Animal Health
Research Lab, Auburn,AL
20-Sep-10
27-Sep-10
04-Oct-10
11-Oct-10
18-Oct-10
25-Oct-10
01-Nov-10
08-Nov-10
" Vaccine Immunology "
“Influenza Vaccines “
“Vaccines for STDs: Safe Sex Across the Animal Kingdom”
“
Vaccine: the Controversial Story of
Medicine's Greatest Lifesaver
”
“Humoral and Cell-mediated Immunity in Acute Viral Infections”
“Malaria Vaccines”
“Cancer Vaccines in Veterinary
Medicine”
“Systems Vaccinology”
Karim Essani, Department of
Biological Sciences, Western
Michigan University
Suryaprakash Sambhara,
Center for Disease Control
Dalen Agnew, Diagnostic
Center for Population and
Animal Health, Michigan State
University
Arthur Allen, Author,
Washington DC
Mark Slifka, Oregon Health &
Science University, Vaccine and Gene Therapy Institute
Stephen Hoffman, CEO,
Sanaria
Rowan Milner, Department of
Small Animal Clinical
Sciences, University of Florida
Bali Pulendran, Emory
Vaccine Center
15-Nov-10
22-Nov-10
29-Nov-10
“Vaccine Safety and Pediatric Infectious
Diseases”
“The emergence and control of influenza viruses”
“Unusual Viral Vaccines in Veterinary
Medicine”
Michael J. Smith, University of
Louisville Pediatrics
Robert Webster, St. Judes
Childrens Research Hospital
Ronald Schultz, Pathobiology
Department, University of
Wisconsin, Madison

06-Dec-08
“ Cellular Immunity”
Duncan Mwangi, Pfizer, Inc.
Course Policies
Students taking the course for credit should refer to WMU or MSU guidelines.
Attendance
Students taking this course for credit are required to attend each seminar and will need to contact Dr. Rob Eversole to make arrangements if they intend to miss a class. Others attending this seminar series are encouraged to attend each seminar, if possible, and arrive on time for minimal disruption to the speakers.
Class Participation
This program will encourage questions from the audience. Questions will be held until the end of the lecture. Following the lecture there will be a question and answer period which will be led by the moderator. All students taking this course for credit are required to ask at least 2 questions at each lecture during the QA portion of the class.
Missed Assignments
Generally speaking, missing assignments is not a good policy; however, there are always reasons for this occurrence. Therefore, students enrolled for credit that miss assignments will need to resolve the issue with WMU. Please contact Dr. Rob Eversole for arrangements.
Academic Honesty
“You are responsible for making yourself aware of and understanding the policies and procedures in the Undergraduate and Graduate Catalogs that pertain to Academic
Honesty. These policies include cheating, fabrication, falsification and forgery, multiple submission, plagiarism, complicity and computer misuse. [The policies can be found at http://catalog.wmich.edu
under Academic Policies, Student Rights and Responsibilities.]
If there is reason to believe you have been involved in academic dishonesty, you will be referred to the Office of Student Conduct. You will be given the opportunity to review the charge(s). If you believe you are not responsible, you will have the opportunity for a hearing. You should consult with your instructor if you are uncertain about an issue of academic honesty prior to the submission of an assignment or test.”
Grading
Dr. Rob Eversole of Western Michigan University is the Instructor of record for this course and will set the policy for grading. Students taking this course for credit will be required to write a weekly summary (hardcopy, 3-4 pages, double-spaced) and detail the significance of the discussion. Weekly reports are due at the beginning of class one week after the talk has been given. Also, a final 15-20 page report (hardcopy, double-spaced w/o images, graphs or tables which can be indexed at the end) is to be written detailing

the overall processes required for developing a vaccine from concept through commercialization and is due December 13th.
Points System:
13 Weekly summaries, 12 points each…………………………156
13 weekly questions for the speaker, 8 points each……………104
Final Report Paper ………………………………….................240
Total…………………………………………………………….500
Scale: 100-90% A
85-89% BA
80-84% B
75-79% CB
70-74% C
65-69% DC
55-65% D
< 55% E