Brugada Syndrome

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Quarterly Review of Literature
July—September 2012
Arrhythmias
A common variant in SLC8A1 is associated with the duration of the electrocardiographic QT interval.
Kim JW, Hong KW, Go MJ, Kim SS, Tabara Y, Kita Y, Tanigawa T, Cho YS, Han BG, Oh B.
Am J Hum Genet. 2012 Jul 13;91(1):180-4. Epub 2012 Jun 21.
PMID: 22726844 [PubMed - indexed for MEDLINE]
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Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic.
Yang T, Atack TC, Stroud DM, Zhang W, Hall L, Roden DM.
Circ Res. 2012 Jul 20;111(3):322-32. Epub 2012 Jun 20.
PMID: 22723299 [PubMed - indexed for MEDLINE]
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Acquired LQTS
Domperidone: ventricular arrhythmia and sudden death (continued).
[No authors listed]
Prescrire Int. 2012 Jul;21(129):183.
PMID: 22852288 [PubMed - indexed for MEDLINE]
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Brugada Syndrome
Brugada syndrome electrocardiographic pattern as a result of improper application of a high pass filter.
García-Niebla J, Serra-Autonell G, Bayés de Luna A.
Am J Cardiol. 2012 Jul 15;110(2):318-20. No abstract available.
PMID: 22732021 [PubMed - indexed for MEDLINE]
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Dilated Cardiomyopathy (DCM)
Where genome meets phenome: rationale for integrating genetic and protein biomarkers in the diagnosis and
management of dilated cardiomyopathy and heart failure.
Piran S, Liu P, Morales A, Hershberger RE.
J Am Coll Cardiol. 2012 Jul 24;60(4):283-9. Review.
PMID: 22813604 [PubMed - indexed for MEDLINE]
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Exercise training in dilated cardiomyopathy improves rest and stress cardiac function without changes in cardiac
high energy phosphate metabolism.
Holloway CJ, Dass S, Suttie JJ, Rider OJ, Cox P, Cochlin LE, Jackson H, Fast AM, Johnson AW, Karamitsos TD,
Neubauer S, Clarke K.
Heart. 2012 Jul;98(14):1083-90.
PMID: 22739638 [PubMed - indexed for MEDLINE]
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Lagged segmented Poincaré plot analysis for risk stratification in patients with dilated cardiomyopathy.
Voss A, Fischer C, Schroeder R, Figulla HR, Goernig M.
Med Biol Eng Comput. 2012 Jul;50(7):727-36. Epub 2012 Jun 12.
PMID: 22689265 [PubMed - indexed for MEDLINE]
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Supporting Families. Saving Lives.
508 E. So. Temple, Suite 202 •Salt Lake City, UT 84102 •800.796.7723 •801.531.0937 •fax 801.531.0945 •www.StopSADS.org
Knockdown of cytochrome P450 2E1 inhibits oxidative stress and apoptosis in the cTnT(R141W) dilated
cardiomyopathy transgenic mice.
Lu D, Ma Y, Zhang W, Bao D, Dong W, Lian H, Huang L, Zhang L.
Hypertension. 2012 Jul;60(1):81-9. Epub 2012 Jun 4.
PMID: 22665122 [PubMed - indexed for MEDLINE]
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HCM
Electrophysiological findings in Fabry cardiomyopathy: mapping the maze of risk stratification.
Li J, Warth A, Schnabel P, Schweizer PA, Buss SJ, Steen H, Becker R, Katus HA, Thomas D.
Acta Cardiol. 2012 Aug;67(4):481-5.
PMID: 22998007 [PubMed - indexed for MEDLINE]
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Circulating matrix metalloproteinases in adolescents with hypertrophic cardiomyopathy and ventricular arrhythmia.
Zachariah JP, Colan SD, Lang P, Triedman JK, Alexander ME, Walsh EP, Berul CI, Cecchin F.
Circ Heart Fail. 2012 Jul 1;5(4):462-6. Epub 2012 May 24.
PMID: 22628530 [PubMed - indexed for MEDLINE]
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Implanted Cardiodefibrillator (ICDs) and AED’s
Cardiac arrests. Hospitals anxious they could face hefty false claims penalties in implanted cardiac defibrillator
cases.
Carlson J.
Mod Healthc. 2012 Jul 23;42(30):6-7, 16, 1.
PMID: 22950260 [PubMed - indexed for MEDLINE]
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Automated external defibrillators in West Virginia schools.
Mercer CW, Rhodes LA, Phillips JR.
W V Med J. 2012 Jul-Aug;108(4):18-24.
PMID: 22872961 [PubMed - indexed for MEDLINE]
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Assessment of myocardial scarring improves risk stratification in patients evaluated for cardiac defibrillator
implantation.
Klem I, Weinsaft JW, Bahnson TD, Hegland D, Kim HW, Hayes B, Parker MA, Judd RM, Kim RJ.
J Am Coll Cardiol. 2012 Jul 31;60(5):408-20.
PMID: 22835669 [PubMed - indexed for MEDLINE]
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Long QT Syndrome (LQTS)
hERG K(+) channels: structure, function, and clinical significance.
Vandenberg JI, Perry MD, Perrin MJ, Mann SA, Ke Y, Hill AP.
Physiol Rev. 2012 Jul;92(3):1393-478. Review.
PMID: 22988594 [PubMed - indexed for MEDLINE]
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Competitive sports participation in athletes with congenital long QT syndrome.
Johnson JN, Ackerman MJ.
JAMA. 2012 Aug 22;308(8):764-5. No abstract available.
PMID: 22820673 [PubMed - indexed for MEDLINE]
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SADS Quarterly Research Literature Review 2012 – Q3. Page 2
Repolarization syndromes.
Bhatia A, Sra J, Akhtar M.
Curr Probl Cardiol. 2012 Aug;37(8):317-62. Review.
PMID: 22749026 [PubMed - indexed for MEDLINE]
Related citations
Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional
KCNQ1 potassium channel.
Zhang H, Zou B, Yu H, Moretti A, Wang X, Yan W, Babcock JJ, Bellin M, McManus OB, Tomaselli G, Nan F,
Laugwitz KL, Li M.
Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11866-71. doi: 10.1073/pnas.1205266109. Epub 2012 Jun 28.
PMID: 22745159 [PubMed - indexed for MEDLINE]
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Miscellaneous
Successful resuscitation from two cardiac arrests in a female patient with critical aortic stenosis, severe mitral
regurgitation and coronary artery disease.
Mijusković D, Stamenković DM, Borović S, Karanikolas M.
Vojnosanit Pregl. 2012 Aug;69(8):714-6.
PMID: 22924269 [PubMed - indexed for MEDLINE]
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M-health revisited.
Ackerman MJ.
J Med Pract Manage. 2012 Jul-Aug;28(1):72-3. No abstract available.
PMID: 22920035 [PubMed - indexed for MEDLINE]
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A controlled trial of electronic automated advisory vital signs monitoring in general hospital wards.
Bellomo R, Ackerman M, Bailey M, Beale R, Clancy G, Danesh V, Hvarfner A, Jimenez E, Konrad D, Lecardo M,
Pattee KS, Ritchie J, Sherman K, Tangkau P; Vital Signs to Identify, Target, and Assess Level of Care Study
(VITAL Care Study) Investigators.
Crit Care Med. 2012 Aug;40(8):2349-61.
PMID: 22809908 [PubMed - indexed for MEDLINE]
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Cardiovascular safety of central nervous system stimulants in children and adolescents: population based cohort
study.
Winterstein AG, Gerhard T, Kubilis P, Saidi A, Linden S, Crystal S, Zito J, Shuster JJ, Olfson M.
BMJ. 2012 Jul 18;345:e4627. doi: 10.1136/bmj.e4627.
PMID: 22809800 [PubMed - indexed for MEDLINE] Free PMC Article
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Postoperative QT interval prolongation in patients undergoing noncardiac surgery under general anesthesia.
Nagele P, Pal S, Brown F, Blood J, Miller JP, Johnston J.
Anesthesiology. 2012 Aug;117(2):321-8.
PMID: 22692379 [PubMed - indexed for MEDLINE]
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Simple treatment options exist for supraventricular tachycardia in pregnancy.
Ripley DP, Shome JJ, Khan S, Turley AJ.
J Obstet Gynaecol. 2012 Jul;32(5):502. No abstract available.
PMID: 22663338 [PubMed - indexed for MEDLINE]
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Genetics and cardiovascular disease: a policy statement from the American Heart Association.
Ashley EA, Hershberger RE, Caleshu C, Ellinor PT, Garcia JG, Herrington DM, Ho CY, Johnson JA, Kittner SJ,
Macrae CA, Mudd-Martin G, Rader DJ, Roden DM, Scholes D, Sellke FW, Towbin JA, Van Eyk J, Worrall BB;
American Heart Association Advocacy Coordinating Committee.
Circulation. 2012 Jul 3;126(1):142-57. Epub 2012 May 29. No abstract available.
PMID: 22645291 [PubMed - indexed for MEDLINE]
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SADS Quarterly Research Literature Review 2012 – Q3. Page 3
Sudden Cardiac Arrest (SCA)/Sudden Cardiac Death (SCD)
Drowning.
Tester DJ, Ackerman MJ.
N Engl J Med. 2012 Aug 23;367(8):777; author reply 777-8. No abstract available.
PMID: 22913702 [PubMed - indexed for MEDLINE]
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Economic evaluation of strategies to reduce sudden cardiac death in young athletes.
Schoenbaum M, Denchev P, Vitiello B, Kaltman JR.
Pediatrics. 2012 Aug;130(2):e380-9. doi: 10.1542/peds.2011-3241. Epub 2012 Jul 2.
PMID: 22753553 [PubMed - indexed for MEDLINE]
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SADS Quarterly Research Literature Review 2012 – Q3. Page 4
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