QUANHU SHENG
Computational Omics Lab, School of Informatics
Indiana University, Bloomington
1900 E 10th St, Bloomington, IN 47406, USA
sheng@indiana.edu
ACADEMIC BACKGROUND
Visiting Scholar, March 2006-present
School of Informatics
Indiana University Bloomington, USA
Ph.D student, Bioinformatics, September 2005-present
Shanghai Institutes for Biological Sciences
Chinese Academy of Sciences, China
M.S., Biochemistry and Molecular Biology, August 2003
Shanghai Institutes for Biological Sciences
Chinese Academy of Sciences, China
B.S., Botany, June 1995
Department of Biology
Nanjing University, China
PROFESSIONAL OVERVIEW
Assistant Professor, Research Center for Proteome Analysis
Institute of Biochemistry and Cell Biology, Shanghai Institutes for
Biological Sciences, Chinese Academy of Sciences, China
August 2003-August 2005
Assistant Professor, Bioinformatics and Computational Biology Laboratory
Institute of Biochemistry and Cell Biology, Shanghai Institutes for
Biological Sciences, Chinese Academy of Sciences, China
February 2002-July 2003
Research Assistant, Bioinformatics and Computational Biology Laboratory
Institute of Biochemistry and Cell Biology, Shanghai Institutes for
Biological Sciences, Chinese Academy of Sciences, China
August 1995-January 2002
AREAS OF EXPERTISE
Tandem Mass Spectra Interpretation
Proteomics Data Analysis
Biological Database Construction
Fragment Assembly in DNA Sequencing
PUBLICATIONS
1． Sheng QH, Wang LS, Dai J, Jiang XS, Li RX, Ma DJ, Li YX, Zeng R, Wu JR:
Comparison of a proteomic approach with a microarray-based approach to
detect exons in the mouse genome. Nat Genet 2006, 38(11):1223-1224.
2. Zhou H, Chen B, Li RX, Sheng QH, Li SJ, Zhang L, Li L, Xia QC, Wang HY,
Zeng R: Large-scale identification of human biliary proteins from a
cholesterol stone patient using a proteomic approach. Rapid Commun Mass
Spectrom 2005, 19(23):3569-3578.
3. Tu CJ, Dai J, Li SJ, Sheng QH, Deng WJ, Xia QC, Zeng R: High-sensitivity
analysis of human plasma proteome by immobilized isoelectric focusing
fractionation coupled to mass spectrometry identification. J Proteome Res
2005, 4(4):1265-1273.
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Li RX, Zhou H, Li SJ, Sheng QH, Xia QC, Zeng R: Prefractionation of proteome
by liquid isoelectric focusing prior to two-dimensional liquid
chromatography mass spectrometric identification. J Proteome Res 2005,
4(4):1256-1264.
Jiang XS, Dai J, Sheng QH, Zhang L, Xia QC, Wu JR, Zeng R: A comparative
proteomic strategy for subcellular proteome research: ICAT approach
coupled with bioinformatics prediction to ascertain rat liver
mitochondrial proteins and indication of mitochondrial localization for
catalase. Mol Cell Proteomics 2005, 4(1):12-34.
He P, He HZ, Dai J, Wang Y, Sheng QH, Zhou LP, Zhang ZS, Sun YL, Liu F,
Wang K et al: The human plasma proteome: analysis of Chinese serum using
shotgun strategy. Proteomics 2005, 5(13):3442-3453.
Dai J, Shieh CH, Sheng QH, Zhou H, Zeng R: Proteomic analysis with integrated
multiple dimensional liquid chromatography/mass spectrometry based on
elution of ion exchange column using pH steps. Anal Chem 2005,
77(18):5793-5799.
Zeng R, Ruan HQ, Jiang XS, Zhou H, Shi L, Zhang L, Sheng QH, Tu Q, Xia
QC, Wu JR: Proteomic analysis of SARS associated coronavirus using
two-dimensional liquid chromatography mass spectrometry and
one-dimensional sodium dodecyl sulfate-polyacrylamide gel
electrophoresis followed by mass spectroemtric analysis. J Proteome Res
2004, 3(3):549-555.
Jiang XS, Zhou H, Zhang L, Sheng QH, Li SJ, Li L, Hao P, Li YX, Xia QC,
Wu JR et al: A high-throughput approach for subcellular proteome:
identification of rat liver proteins using subcellular fractionation
coupled with two-dimensional liquid chromatography tandem mass
spectrometry and bioinformatic analysis. Mol Cell Proteomics 2004,
3(5):441-455.
Sheng QH, Tang HX, Xie T, Wang LS, Ding DF: A novel approach for peptide
identification by tandem mass spectrometry. Acta Biochimica et Biophysica
Sinica 2003, 35(8):734-740.
Xie T, Sheng QH, Ding DF: Reconstruction of ABC Transporter Pathways of
Archaea and Comparison of Their Genomes. Acta Biochimica et Biophysica
Sinica 2000, 32(2):169-174.
Sheng QH, Xie T, Ding DF: De Novo interpretation of MS/MS spectra and protein
identification via database searching. Acta Biochimica et Biophysica
Sinica 2000, 33(6):801-806.
Xie T, Sheng QH, Ding DF: The relationship between yeast coexpressed gene
clusters and their upstream cis-acting elements. Acta Biochimica et
Biophysica Sinica 1999, 31(6):718-722.
Xie T, Sheng QH, Ding DF: The feasibility of using proteome expression
profile for genome annotation. Acta Biochimica et Biophysica Sinica 1999,
31(4):451-455.
Sheng QH, Ding DF: An assembly algorithm for DNA sequence with repeats.
Acta Biochimica et Biophysica Sinica 1998, 30(1):53-58.