Editorially Revised 3-22-06
University Curriculum Committee
Course Proposal Form
for Courses Numbered 0001 – 4999
(Faculty Senate Resolution #04–18, April 2004)
Note: Before completing this form, please read the accompanying instructions
carefully.
CLSC 3410,
3411
1. Course Prefix and Number: CLSC 3410, 3411
01/29/2007
2. Date: 01/29/2007
3. Requested Action (check only one box):
X
New Course
Revision of Active Course
Revision & Unbanking of a Banked Course
Renumbering of an Existing Course
from #
to
#
4. Justification for new course or course revision or renumbering:
Lecture and laboratory content on hemostasis is being moved from CLSC 3420, 3421
to CLSC 3410, 3411. Content of CLSC 3420, 3421 is over-crowded with just
abnormal hematology content, whereas CLSC 3410, 3411 is not content overcrowded.
5. Course description exactly as it should appear in the next catalog:
3410, 3411. Hematology I Lecture and Laboratory (3,1) (F) 3 lecture hours and 3
lab hours per week. Formation and morphology of cellular elements of blood and
hematologic findings in normal blood samples. Normal hemostasis, hemostatic
disorders, and lab evaluation and monitoring of hemostasis. Lab covers manual
hematologic analyses, peripheral blood and bone marrow smear evaluations from
normal samples, and samples from coagulation tests.
6. If this is a course revision, briefly describe the requested change:
Add lecture and lab content on hemostasis to CLSC 3410, 3411 to balance course
content distribution for more effective student learning.
7. Undergraduate Catalog Page Number from current undergraduate catalog:
341
2
8. The Writing Across the Curriculum Committee must approve Writing Intensive
(WI) credit for all courses prior to their consideration by the UCC. If WI credit is
requested, has this course been approved for Writing Intensive (WI) credit?
Not applicable.
Yes
No
If Yes, will all sections be Writing Intensive (yes/no)?
Yes
No
9. Any course requesting Foundations Curriculum credit must be
reviewed by Academic Standards Committee prior to their consideration by
the UCC. If FC credit has been approved by the ASC, then check the
appropriate box (check at most one), otherwise leave all boxes blank.
English (EN)
Humanities (HU)
Fine Arts (FA)
Health (HL)
Science (SC)
Social Science (SO)
Mathematics (MA)
Exercise (EX)
10. Course Credit: Note: CLSC 3410 is lecture course, CLSC 3411 is lab course.
Lecture
3
Per
Credit
3
Weekly OR
42
s.h.
Hours
Term Hours
3
Per
Credit
1
Lab
Weekly OR
42
s.h.
Term Hours
Per
Credit
Studio
Weekly OR
s.h.
Term Hours
Per
Credit
Practicum
Weekly OR
s.h.
Term Hours
Per
Credit
Internship
Weekly OR
s.h.
Term Hours
Other (e.g., independent study) Please explain.
Total Credit Hours 4
s.h.
11. Anticipated yearly student enrollment: 16
12. Affected Degrees or Academic Programs:
Current
Degree(s)/Course(s)
Catalog Page
B.S. in Clinical Laboratory
169
Science
Changes in Degree Hours
None
3
13.
Overlap or Duplication with Affected Units or Programs:
Not Applicable
x
Applicable (notification and responses from affected units are
attached)
14. Approval by the Council for Teacher Education (required for courses affecting
teacher education programs):
x
Not Applicable
Applicable (CTE has given its approval.)
15.
Statements of Support:
x
Current staff is adequate
Additional staff is needed (describe needs in the box below):
x
Current facilities are adequate
Additional facilities are needed (describe needs in the box below):
x
Initial library resources are adequate
Initial resources are needed (in the box below, give a brief
explanation and an estimate for the cost of acquisition of required
initial resources):
x
Unit computer resources are adequate
Additional unit computer resources are needed (in the box below,
give a brief explanation and an estimate for the cost of acquisition):
x
ITCS resources are not needed
The following ITCS resources are needed (put a check beside each
need):
Mainframe computer system
Statistical services
Network connections
Computer lab for students
4
Remember to forward email approval from the director of ITCS to
UCC.
16. Syllabus – please insert course syllabus below. You must include (a) the
name of the textbook chosen for the course, (b) the course objectives, (c) the
course content outline, and (d) the course assignments and grading plan.
Course syllabi for CLSC 3410 and 3411 show placement of
hemostasis content as italicized and bolded in the syllabi.
CLSC 3410: HEMATOLOGY I LECTURE (3 sh)
Course meets for 3 lecture hours per week.
TEXTS:
Hematology: Clinical Principles and Applications (2nd ed.), BF Rodak, W.B. Saunders, 2002.
Clinical Hematology Atlas (2nd ed.), JH Carr & BF Rodak, W.B. Saunders, 2004 or 2005.
Urinalysis and Body Fluids (4th ed.), SK Strasinger & MS DiLorenzo, F.A. Davis, 2001
Overall Objectives for CLSC 3410
Upon the completion of CLSC 3410, the student will be able to do the following with at least 70% accuracy:
1. Describe the current theories of stem cell differentiation and maturation.
2. Describe fetal and adult hematopoiesis.
3. Explain the development of normal erythrocytes, normal red cell metabolism, the process of
normal iron metabolism, and normal hemoglobin synthesis and catabolism.
4. Explain lymphocytic cell development in terms of T cells, B cells, and plasma cells and their
functions in the immune process/system.
5. Describe granulocytic and monocytic cell development and function.
6. Describe the process of phagocytosis by normal cells.
7. Describe normal platelet development and function.
8. Describe normal hemostasis in relation to properties and interactions of coagulation factors.
9. Describe normal fibrinolysis process in relation to properties and interactions of fibrinolytic
factors and their interactions with hemostasis factors.
10. Describe naturally occurring and synthetic antithrombotic substances and their interactions
with hemostasis and fibrinolytic factors.
11. For each hemostatic and fibrinolytic disorder covered in CLSC 3410, describe the etiology,
usual results for PT, APTT, bleeding time, and platelet count and morphology, usual
diagnostic tests beyond routine coagulation tests and the associated findings, applicable
decision pathways for lab testing related to the disorder, therapies, and usual lab test(s) done
to monitor disorder progress.
12. Describe major causes of thrombotic tendencies in patients, associated laboratory test results,
and therapies.
13. Describe specimen acceptability, and the common procedures and interpret results for
seminal fluid analysis.
14. Describe normal and abnormal constituents of each of the following based on microscopic
examination and interpret results: cerebrospinal fluid, pericardial fluid, pleural fluid, synovial
fluid, amniotic fluid, peritoneal fluid, and paracentesis fluid.
Note: objectives specific to each chapter are included in the course pack.
Lecture Topics and Reading Assignments
Date
Class 1
Class 2
Class 3
Class 4
Class 5
Class 6
Class 7
Class 8
Class 9
Class 10
Class 11
Class 12
Class 13
Topic
Assignment in Rodak
Hematopoiesis
Chapter 6
Hematopoiesis continued
Morphology and Function of Cellular Components
Chapter 5
Morphology and Function continued
Erythrocyte Production and Destruction
Chapter 7
Erythrocyte P&D continued
Erythrocyte P & D continued
Hemoglobin and Iron Metabolism
Chapters 9, 10
Hemoglobin and Iron continued
Hemoglobin and Iron continued
Metabolism of the Erythrocyte
Chapter 8
Metabolism of the Erythrocyte continued
Leukocytes
Chapter 11
5
Class 14
Class 15
Class 16
Class 17
Class 18
Leukocytes continued
Leukocytes continued
Leukocytes continued
Bone Marrow
Bone Marrow continued
Class 19
Class 20
Class 21
Class 22
Class 23
Class 24
Class 25
Class 26
Cerebrospinal Fluid Analysis
Cerebrospinal Fluid Analysis continued
Synovial Fluid Analysis
Seminal Fluid Analysis
Fecal Analysis
Pleural, Pericardial, and Peritoneal Fluids Analysis
Amniotic Fluid Analysis
Other Body Fluids Analyses
Chapter 15
Assignment in Strasinger
Chapter 13
Chapter 14
Chapter 11
Chapter 10
Chapter 15
Chapter 12
Assignment in Rodak
Introduction to Normal Hemostasis and
Chapter 12,
Blood Vessels, Platelets
Chapter 45 pp. 609-614
Class 28 Introduction….. continued
Class 29 Platelet Disorders
Chapters 45, 46
Class 30 Platelet Disorders continued
Class 31 Coagulation Factors and Hemostasis
Chapter 42
Class 32 Coagulation continued
Class 33 Coagulation continue
Class 34 Hemorrhagic Disorders
Chapter 43
Class 35 Hemorrhagic Disorders continued
Class 36 Thrombosis Risk Testing
Chapter 44
Class 37 Thrombosis Risk Testing continued
Class 38 Thrombosis Risk Testing continued
Class 39 Evaluation of Hemostasis
Chapters 47
Class 40
Evaluation of Hemostasis continued
Class 41 Intra-lab Variation in Hemostasis Testing
Handouts
Class 42 Hemostasis Instrumentation & Future Directions
Chapter 48
Class 27
GRADING SYSTEM/SCALE
Evaluation Item
Completion of CD’s
Exam 1
Exam 2
Exam 3
Exam 4
Final Exam
Professional Behavior & Class Preparedness
Grading Scale:
% of Total Points
90 - 100
80 - 89
70 - 79
60 - 69
0 - 59
% of Total Points
5%
15%
15%
15%
15%
30%
5%
Course Grade
A
B
C
D
F
6
CLSC 3411: HEMATOLOGY I LABORATORY (1sh)
Lab meets once a week for 3 hours.
TEXTS:
Hematology: Clinical Principles and Applications (2nd ed.). BF Rodak, W.B. Saunders, 2002.
Clinical Hematology Atlas (2nd ed). JC Carr & BF Rodak, Elsevier Saunders, 2004.
Urinalysis and Body Fluids (4th ed.), SK Strasinger & MS DiLorenzo, F.A. Davis, 2001.
CLSC 3411 Lab Manual.
OBJECTIVES:
Upon completion of CLSC 3411, the student will have achieved basic competency as a MT/CLS in the following practical clinical laboratory
science performance attributes:
1. Operate a binocular microscope for optimal maintenance and preservation of microscope, and
accurate viewing of slides.
2. Perform laboratory work safely and adhering to universal precautions.
3. Perform a whole blood sample analysis on the Cell-Dyn 1600; understand the basics of the Cell-Dyn: operation, reagents, calibration,
background counts, and quality control.
4. Complete a Unopette white blood cell count.
5. Prepare peripheral blood smears for staining.
6. Stain peripheral blood smears manually and on automated instrument.
7. Complete white cell differential and morphology, red cell morphology, and platelet
count estimate and morphology on stained peripheral smears from normal EDTA blood
samples.
8. Recognize cells at all stages of maturation for both white and red blood cells.
9. Estimate white blood cell count on stained peripheral smear from an EDTA blood sample.
10. Calculate MCV, MCH and MCHC from the red cell count, hemoglobin and hematocrit.
11. Perform erythrocyte sedimentation rate by Westergren method.
12. Perform hematocrit by microhematocrit centrifuge method from EDTA blood sample.
13. Perform hemoglobin manually by cyanomethemoglobin method from EDTA blood sample.
14. Calculate absolute values of leukocytes from relative values and WBC total counts.
15. Perform WBC count by hemacytometer and differential on simulated CSF sample.
16. Identify cellular elements and crystals on stained slides from synovial, pleural, peritoneal, paracentesis, thoracentesis, and pericardial fluids.
17. Operate a cytocentrifuge for preparation of acceptable smears of body fluid for staining and microscopic examination.
18. Describe test principle, perform, report and interpret results for the following hemostasis tests: PT, APTT, bleeding time, D-dimer test, FDP
test, DVV test, and correction studies with normal plasma in identifying a factor deficiency versus an inhibitor.
19. Describe test principle, reagents, procedure, technical problems and cautions, interpretation of results and clinical applications for the
following hemostasis tests: platelet aggregation, ACT, Stypven Time, Thrombin Time, Reptilase Time, Fibrinogen level (immunoassay and
clot-based methods), Factor XII screen, ATIII test, APC Resistance test, Protein C and S assays, Euglobulin Lysis, Prothrombin 1 and 2
Fragments test, and Factor activity assays.
7
NORMAL HEMATOLOGY
Lab
#1
Assignment in Rodak
- Understanding universal precautions
- Using the binocular microscope
R: 31-40
#2
- Hematology specimens
- Performing manual cell counts
- Introduction to the Cell-Dyn 1600
R: 19-21
R: 154-158
#3
- Performing erythrocyte sedimentation rates
- Performing manual hemoglobins
- Performing manual hematocrits
R: 166-168
R: 158-161
R: 161-163
#4/5
- Preparing a peripheral blood smear (PBS)
- Staining a PBS
- Identification of normal, mature white
blood cells in peripheral blood smears (PBS)
- Red cell indices
R: 171-176
R: 176-178
R: 178-182
R: 163-164
#6
- Performing PBS evaluations and WBC differentials
on normal PBSs
- Relative and absolute WBC values
R: 178-182
#7
- Performing PBS evaluations and WBC differentials
on normal PBSs (continued)
#8
- Identification of normal, immature red
and white blood cells on bone marrow smears
#9
NORMAL HEMATOLOGY WRITTEN AND PRACTICAL EXAMS
R: 185-195
BODY FLUIDS
#10
#11
- Performing WBC counts and differentials
on CSF
- Performing microscopic exam of
cytocentrifuged body fluids
S: 149-165
- Performing microscopic exam of body
fluids (continued)
S: 179-199
R: 591-604
8
HEMOSTASIS (i.e., COAGULATION)
#12
- Hemostasis lab procedures, specimens,
and quality control
- Bleeding times
- Prothrombin times (PTs)
- Activated partial thromboplastin times (APTTs)
R: 720-739
#13
- Lupus anticoagulants, DVV test
- D-dimer, FDP
- Correction studies and factor deficiency
practice problems & wet lab
- Factor deficiency unknown problems
#14
HEMOSTASIS AND BODY FLUIDS WRITTEN EXAM
Factor Deficiency Unknown Problems Due!
R: 742-748
Note for Hemostasis and Body Fluids Written Exam:
Though demonstration or hands-on experience with the following hemostasis tests/ procedures is not possible, students are
responsible for being able to demonstrate understanding of the following on the Hemostasis and Body Fluids Written Exam:
- Hemostasis instrumentation
- Platelet aggregation
- Activated clotting time (ACT)
- Russell’s Viper Venom (DVV)
- Thrombin time
- Reptilase time
- Fibrinogen level
(immunoassay & clot-based tests)
- Factor assays
- Factor XIII screen
- von Willebrand testing
- Anti-thrombin III (ATIII) test
- Protein S and C assays
- APC Resistance test
- Heparin assay
- Prothrombin Fragments 1 & 2, & 20210A
- Euglobulin lysis
- Bethesda Titer for Factor VIII Inhibitor
- Plasminogen assay
- Plasminogen Activator Inhibitor assay
- TPA assay
R: 755-767
R: 726-730
R: 732-733
R: 660
R: 740-742
R: 742
R: 742-743
R: 743-746
R: 745-746
R: 635, 729-730
R: 663-665
R: 665-667
R: 667-668
R: 664
R: 668, 675
R: 749-750
R: 745
R: 748
R: 749
R: 748-749