1. A pharmacy analyst The refractive index of water at 20 °C equal to 1.3330.
supervises the state of a
refractometer. For its
calibration he needs
some distilled water.
The distilled water must
have the following
value of the refractive
index:
A 1,3330
B 1,3110
C 1,3220
D 1,3440
E 1,3550
2. A chemist of an
analytic laboratory has
to prepare turbidity
standards according to
the requirements of
Pharmacopoeia. What
substances are to be
used as the reference?
A
Hexamethylenetetramin
e and hydrazine
B Sodium chloride and
calcium nitrate
C Calcium sulfate and
glycerol
D Potassium chloride
and barium sulfate
E Furacillin
calcium chloride
and
3. Specify the reaction Reaction to the ester-type drugs is that of forming iron (III)
to the ester-type drugs
have a bluish-red or red colour:
that is tolerated by the
Ukrainian
State
hydr
oxamates which
Pharmacopoeia:
A Formation of iron
hydroxamates
B Formation of azo dye
C Formation of
indophenol
D Formation of 3bromphenol
E Formation of
tayleohin
4. Presence of phenyl
hydroxyl can be
confirmed by the
reaction with solution
of:
Presence of phenyl hydroxyl can be confirmed by the
reaction with FeCl3 solution – a violet colour is produced:
A Iron (III) chloride
solution
B Iodine alcohol
solution
C Hydrochloric acid
solution
D Solution of iodine in
potassium iodide
E Silver nitrate solution
5. A pharmacist-analyst
is
measuring
the
quantity of a drug by
method of indirect
bromatometry. Which of
the following titrated
solutions is to be used?
A Sodium thiosulfate
B Calcium bromate
C Sodium edetate
The procedure of quantitative determination of drugs by indirect bromatometry:
potassium bromide, an acid and an excess of a titrated potassium bromate solution are
added to the analyte solution. The excess of bromine is determined iodimetrically:
Titrate with sodium thiosulphate, using starch solution as indicator.
D Sodium nitrite
E Argentum nitricum
(silver nitrate)
6. What is a general Argentometry allows quantitative determinate chlorides, bromides and iodides. It is
method of quantitative based on reaction of halogenide ions with volumetric solution of silver nitrate:
determination
of
Ag+ + Cl– → AgCl↓
halogenides of alkaline
Ag+ + Br– → AgBr↓
metals?
A Argentometry
B Permanganatometry
Ag+ + I– → AgI↓
Therefore argentometry is a general method of quantitative determination of
halogenides of alkaline metals.
C Nitritometry
D Chelatometry
E Alkalimetry
7. A pharmacy analyst According to the State Pharmacopoeia of Ukraine the following test for oxidisable
analizes distilled water. substances is carried out: to distilled water add dilute sulphuric acid and 0.02 M
For this purpose he potassium permanganate and boil for 5 min; the solution remains faintly pink.
brings some amount of
the sample material to
the boiling point, adds
0,02 M solution of
potassium
permanganate
and
diluted sulfuric acid.
After 5 minutes of
boiling the pink colour
of the produced solution
should not change. The
pharmacy analyst tries
to detect the following
admixture:
A Chemical reducing
agent
B Carbon dioxide
C Nitrates
D Sulfates
E Heavy metals
8. A pharmacy analyst The semi-micro determination of water is based upon the quantitative reaction of water
carries out analysis of with sulphur dioxide and iodine in a suitable anhydrous medium in the presence of a
ethylmorphine
base with sufficient buffering capacity.
hydrochloride.
For
determination
of
admixture of water by
semi-micromethod he
uses:
A Iodosulphurous
reagent
B Hypophosphite
reagent
C Methoxyphenylacetic
acid
D Biuret reagent
E Molibdotangstic
reagent
9. In order to detect an
Detection of potassium admixtures is based on the reaction
with sodium
admixture of potassium tetraphenylborate:
in medical preparations
a pharmacy analyst
should carry out a
After 5 min, any opalescence in the test solution is not more intense than that in the
reaction with:
standard.
A Sodium
tetraphenylborate
B Sodium tetraborate
C Boric acid
D Sulfuric acid
E Salicylic acid
10. Select the reductant Method 2 detection of arsenic impurity is based on
required
for
the
the reactions with hypophosphorous reagent:
determination of arsenic
impurity
in
drugs
(method 2):
A Sodium
hypophosphite
B Sodium sulphite
After heating on the water-bath, any colour in the test solution is not more intense than
that in the standard.
C Potassium iodide
D Sodium hydroxide
E Hydrochloric acid
11. According to the
requirements of the
Ukrainian
State
Pharmacopoeia,
a
pharmacy analyst is
measuring
iron
admixture
in
a
preparation by means of
citric and thioglycolic
acids. What staining
indicates presence of
this admixture?
Detection of iron admixtures is based on the reaction
with thioglycollic acid in the presence of citric acid solution:
After 5 min, any pink colour in the test solution is not more intense than that in the
standard.
A Pink
B Green
C Yellow
D Blue
E Black
12.
Due
to
the
requirements of State
Pharmacopoeia
of
Ukraine the analystpharmacist
conducts
identification
of
admixture of heavy
metals (method A) with
the use of reagent:
Detection of admixtures of heavy metals is based on
the reaction with thioacetamide reagent:
A Thioacetamide
any brown color in the test solution is not more intense
B Sodium sulfide
than that in the standard solution.
C Sulfosalicylic acid
The solution acidify with hydrochloric acid solution.
The substance to be examined complies with the test if
D Ammonium oxalate
E Potassium iodide
13. A pharmacy analyst Sulphides admixture in sodium thiosulphate is detected with sodium
carries out purity test of
nitroprusside solution:
the drug substance
"Sodium thiosulfate".
Violet
colour,
that
comes from reaction
with
sodium The solution does not become violet.
nitroprusside, indicates
the presence of the
following admixture:
A Specific sulfides
admixture
B Sulphates admixture
C Sulfur admixture
D Sodium chloride
admixture
E Iodides admixture
14. A pharmacy analyst Sodium thiosulphate can be decomposed by hydrochloric
can verify presence of
thiosulfate-ion
in acid with the precipitation of sulphur (yellow) and liberation
sodium thiosulphate by
means of the following of gas which gives a blue colour to starch iodate paper (thiosulfate-ion):
solution:
A Hydrochloric acid
B Sodium hydroxide
C Potassium sulfate
D Sodium nitrate
E Ammonium
hydroxide
15. As main reagent in Detection of admixtures of phosphates is based on the reaction with sulphomolybdic
test for phosphates reagent in the presence of stannous chloride solution:
admixtures
the
Ukrainian
State
Pharmacopoeia
After 10 min, any blue colour in the test solution is not more intense than that in the
recommends to use:
standard.
A Sulfomolybdenum
B Cupric tartrate
C Thioacetamide
D Acetylacetone
EHypophosphite
16. A pharmacy analyst To water solution of sodium hydrocarbonate add phenolphthalein –
identifies
sodium pale pink color is produced (alkalescent medium reaction).
hydrocarbonate. What Gas is evolved and the solution becomes red after heating:
indicator can confirm
the
presence
of
alkalescent
medium
reaction in the sodium
hydrocarbonate
solution?
A Phenolphtalein
B Starch
C Tropeolin 00
D Ferroin
E Naphtholbenzein
17. Sodium salt, treated Sodium is detected in its compounds by the characteristic yellow coloration which it
with hydrochloric acid imparts to colourless flame.
and put into the
colourless flame makes
it:
A Red
B Brick
C Violet
D Yellow
E Green
18. According to the
requirements of the
Ukrainian
State
Pharmacopoeia
(Supplement
1),
a
pharmacy analyst has to
carry out quantitative
analysis of potassium
iodide by means of the
following method:
A Iodatometry
B Complexonometry
The State Pharmacopoeia of Ukraine (Supplement 1) recommends the quantitative
determination of potassium iodide by iodatometric method, direct titration in the
presence of hydrochloric acid. Titrate until the colour of the solution changes from red
to yellow, add chloroform and titrate until the chloroform layer is decolourised, s = 2:
C Acidimetry
D Alkalimetry
E Nitritometry
19. An analyst of a
pharmaceutical
storehouse received the
substance of hydrogen
peroxide for analysis.
Quantitative
determination of this
drug
should
be
performed
by
permanganatometric
method. According to
the analytical normative
document,
titration
should be carried out till
the solution turns:
Quantitative analysis of hydrogen peroxide is performed by
perman ganatometric method, direct titration of an acidified hydrogen
peroxide solution with a solution of potassium permanganate untill the
titration end point is reached, i. e.
when the solution acquires a pale pink colour, S = 2,5:
A Pink
B Green
C Yellow
D Dark blue
E Colourless
20. A pharmacy analyst Mixture of boric acid with methanol (or ethanol) and concentrated sulphuric acid is
of
an
analytical ignited, the flame with a green border is obtained:
laboratory carries out
analysis of boric acid.
Identity is confirmed by
reaction of formation of
methyl or ethyl borate,
which on igniting has a
border of flame of:
A Green сolour
B Red colour
C Violet colour
D Blue colour
E Yellow colour
21. A pharmacy analyst
of
an
analytical
laboratory is studying
borax
(Na2B4O7·10H2O)
according
to
the
requirements of the
Ukrainian
State
Pharmacopoeia. What
method is recommended
by the Ukrainian State
Pharmacopoeia for the
quantitative analysis of
this preparation?
The State Pharmacopoeia of Ukraine recommends the
quantitative determination of borax by alkalimetric method, direct
titration in the presence of mannitol (sometimes can be used
other polyatomic alcohols, for example, glycerol, sorbitol etc.),
indicator – phenolphthalein:
A Alkalimetry
B Iodometry
C Bromatometry
D Nitritometry
E Iodochlormetry
22.
An pharmacy Identification is carried out using general identification reactions for mercury:
analyst conducted the
reaction of identification Mercury (II) chloride is react with potassium iodide solution with forming
of mercury (II) chloride,
as a result of which the of a red precipitate, which dissolves in excess of reagent:
red precipitate was
formed. What reagent
was added?
A Potassium iodide
B Sodium nitrite
C Zinc sulfate
D Magnesium of
chloride
E Ammonium of
bromide
23. A pharmacy analyst The quantitative determination of mercury dichloride is conducted by chelatometric
is measuring mercury method, displacement titration. At first sodium edetate solution and buffer solution pH
dichloride by method of 10.9 are added. Mercury ions form complexes with the titrant:
indirect chelatometry.
Excess
of
titrated
solution of sodium
edetate can be titrated
by means of the
following
titrated
solution:
A Zinc sulfate
B Sodium hydroxide
C Sodium thiosulfate
Then mordant black, used as indicator, is added, and the excess of sodium edetate is
titrated with zinc sulphate solution until the colour changes to purple (first titration).
D Potassium bromate
E Sodium methylate
Then potassium iodide is added to destroy complex Hg-EDTA, and equivalent to mercuri
chloride quantity of sodium edetate is titrated with zinc sulphate (second titration).
For the calculation volume of zinc sulphate solution used in the second titration is
taken. Calculation is made with reference to the dried substance.
24. An analytical
laboratory received
The quantitative determination of calcium gluconate is conducted by chelatometric
calcium gluconate for
analysis. What method
is used for its
quantification?
method, direct titration using calconecarboxylic acid as indicator:
A Chelatometry
B Bromatometry
C Iodometry
D Mercurimetric
determination
E Nitritometric
determination
Titrant is 0,1M sodium edetate, medium is strong sodium hydroxide solution.
Solution is titrated until the colour changes from violet to full blue:
25. According to the The quantitative determination of calcium gluconate is conducted by chelatometric
requirements of the
Ukrainian
State method, direct titration using calconecarboxylic acid as indicator:
Pharmacopoeia,
a
pharmacy analyst is
determining
calcium
gluconate quantity by
method
of
complexometric
titration. What indicator
is to be used?
A Calconcarboxylic
acid
Titrant is 0,1M sodium edetate, medium is strong sodium hydroxide solution.
B Methyl red
Solution is titrated until the colour changes from violet to full blue:
C Crystal violet
D Thymolphthalein
ETropeoline 00
26. According to the
requirements of the
Ukrainian
State
Pharmacopoeia,
a
certain drug is being
measured by method of
chelatometric titration.
What drug is it?
The complexometric method allows quantitative determination of substances, which
contain doubly and triply charged ions of metals (such as Ca2+, Mg2+, Zn2+, Bi3+, Al3+,
Hg2+, etc.).
The State Pharmacopoeia of Ukraine recommends the quantitative determination of
Calcium chloride by chelatometric method, direct titration using calconecarboxylic acid
as indicator:
A Calcium chloride
B Potassium citrate
C Potassium chloride
D Sodium benzoate
E Sodium thiosulfate
Titrant is 0,1M sodium edetate, medium is strong sodium hydroxide solution.
Solution is titrated until the colour changes from violet to full blue:
27.
An
analytical An official reaction for Ca2+ is that with potassium ferrocyanide solution in medium of
laboratory is studying acetic acid in the presence of ammonium chloride – a white, crystalline precipitate is
substance of calcium formed:
lactate. In presence of
ammonium
chloride
calcium cation forms
white
crystalline
precipitation with the
following reagent:
A Potassium
ferrocyanide
B Sodium chloride
C Potassium
permanganate
D Sodium tetraborate
E Sodium cobaltnitrite
28. Calcium lactate can According to the Ukrainian State Pharmacopoeia the quantitative determination of
be
quantitatively
determined
by calcium lactate is conducted by chelatometric method, direct titration
chelatometric method. using calconecarboxylic acid as indicator:
According
to
the
Ukrainian
State
Pharmacopoeia,
the
following
substance
should be used as
indicator:
A Calconcarbon acid
B Diphenylcarbazone
C Naphthol benzein
Titrant is 0,1M sodium edetate, medium is strong sodium hydroxide solution.
D Phenolphthalein
Solution is titrated until the colour changes from violet to full blue:
E Tropeolin 00
29. A pharmacy analyst One of the qualitative reaction of iron cation (II) is reaction with ammonium sulfide – a
can verify presence of black precipitate is formed:
iron cation (II) in a drug
Fe2+ + (NH4)2S = FeS↓ + 2NH4+
formulation by means of
the following solution:
A Ammonium sulfide
B Sodium chloride
C Magnesium sulfate
D Potassium bromide
E Sodium phosphate
30.
An analytical According to the requirements of the Ukrainian State Pharmacopoeia the quantitative
laboratory
has
to
analyze ferrous sulfate determination of ferrum sulphate heptohydrate is conducted by cerimetric titration after
heptahydrate according dissolving the preparation in the previously prepared mixture of sodium hydrogen
to
the
State
Pharmacopoeia
of carbonate, water and sulphuric acid. Titrate with 0,1 M ammonium cerium nitrate
Ukraine. A test portion
(ammonium cerium sulfate), indicator is ferroin. Solution is titrated until the red colour
of the substance should
be titrated with the disappears:
following solution:
3FeSO4 + 3(NH4)2Ce(NO3)6 → Fe2(SO4)3 + Fe(NO3)3 + 3Ce(NO3)3 + 6NH4NO3
A Ammonium cerium
sulfate
B Argentum nitrate
C Ammonium
thiocyanate
D Sodium edetate
E Potassium bromate
31. An analyst is Sodium benzoate is measured by the acidimetric method in non-aqueous media (direct
measuring
sodium
benzoate
in
the titration). Anhydrous acetic acid is used as a solvent. Titrate with with perchloric acid
u by
ntil a green colour is obtained, indicator is naphtholbenzein solution:
anhydrous medium
the acidimetric method
according
to
the
requirements of the
Ukrainian
State
Pharmacopoeia. What
reagent had to be used
as a solvent?
A Anhydrous acetic acid
B Pyridine
C Water
D Dimethyl formamide
E Methanol
32.
Salicylates are Salicylic acid is determined by alkalimetric method, direct titration. Dissolve the
widely
applied
in substance in ethanol (96 per cent), add water. Titrate with sodium hydroxide, using
medical practice as anti- phenol red solution as indicator:
inflammatory drugs. For
quantitative analysis of
salicylic
acid
the
following method is
applied:
A Alkalimetry
B Nitritometry
C Argentometry
D Permanganatometry
E Chelatometry
33. A pharmacy analyst Quantitative determination of silver nitrate: Thiocyanatometric titration after dissolving
is determining silver
nitrate
by the preparation in water and acidifying with dilute nitric acid, using ferric
thiocyanatometry
method. What indicator ammonium sulphate solution as indicator until a reddish-yellow colour is obtained:
is to be used?
A Ferric
sulphate
ammonium
B Methyl orange
AgNO3 + NH4SCN → AgSCN↓ + NH4NO3
3NH4SCN + FeNH4(SO4)2 → Fe(SCN)3 + 2(NH4)2SO4
C Potassium chromate
D Phenolphthalein
E Starch
34. An analytical
The content of sodium citrate in the drug can be determined by ion-exchange
laboratory carries out
quantitative analysis of chromatography on a cationite:
sodium citrate by
method of ionexchanging
chromatography on a
cationite. What titrated
solution is to be used for
Citric acid is neutralised with an alkali (NaOH), the indicator is methyl orange:
the following titration of
generated citric acid?
A Sodium hydroxide
B Iodine
C Potassium iodate
D Hydrochloric acid
E Trilon B
35.
An analytical According to the requirements of the Ukrainian State Pharmacopoeia, citric acid is
laboratory
received determined by alkalimetric method. Titrate with 1 M sodium hydroxide, using
substance of citric acid phenolphthalein as indicator.
for
the
analysis.
According
to
the
requirements of the
Ukrainian
State
Pharmacopoeia, citric
acid can be determined
by method of:
A Alkalimetry
B Iodometry
C Acidimetry
D Bromatometry
E Iodochlorometry
36. In order to identify a Glycerin is heated with potassium hydrogen sulphate in an evaporating bowl.
polyatomic
glycerin Vapours of acrolein are evolved which gives blue colour to the filter paper moistened
alcohol a pharmacy with 1% solution
analyst
carries
out
of sodium nitroprusside and with piperidine:
dehydration
reaction
with
potassium
hydrosulfate.
The
generated hereat product
has
a
strong
characteristic smell and
gives blue colour to the
filter paper moistened
with 1% solution of
sodium
nitroprusside
and with piperidine.
What product is it?
A Acrolein
B Diethyl ether
C Acetic acid
D Ethanol
E Chloroform
37.
An
analytical Admixtures of acetone and aldehydes are determined in diethyl ether (Aether
laboratory
received anaestheticus) with alkaline potassium tetraiodomercurate solution (Nessler’s reagent).
"Aether anaestheticus" The lower layer shows only a slight opalescence:
for
analysis.
What
reagent should be used
for detecting acetone
and aldehyde impurities
according to the State
Pharmacopoeia
of
Ukraine?
A Alkaline solution of
potassium
tetraiodomercurate
B Ammonium solution
of argentum nitrate
C Aqueous solution of
potassium iodide
D Sodium hydrosulfite
solution
E Hydroxylamine
solution
38. In order to detect Determination of peroxides in “Aether anaestheticus”: add KI and starch solutions – no
peroxides
in colour
the is produced.
anesthetic ether an
analytical
chemist
H5C2–O–O–C2H5 + 2KI + H2O → I2 + H5C2–O–C2H5 + 2KOH
should use the following
reagent:
A Potassium iodide
B Potassium chloride
C Potassium
permanganate
D Sodium thiosulfate
E Sodium hydroxide
39.
Quantitative The Ukrainian State Pharmacopoeia recommends determining the content of
analysis
of
diphenhydramine hydrochloride by alkalimety. Dissolve the substance in alcohol, add 5.0
diphenhydramine
ml o of 0.01 M hydrochloric acid. Carry out a potentiometric titration, using 0.1 M sodium
hydrochloride according
to the requirements of hydroxide solution. Use the volume added between the 2 points of inflexion.
the Ukrainian State
Pharmacopoeia
is
carried
out
by
alkalimetry. Which of
the following titrated
solutions is to be used?
A Hydrochloric acid
B Potassium bromate
C
Potassium
permanganate
D Sodium nitrite
E Sodium thiosulfate
40. Qualitative reaction One of the qualitative reaction of phenol is reaction with bromine water – a pale yellow
for phenol is the
reaction with bromine
water. What compound
is produced as a result
of the interaction of
precipitate of 2,4,6-tribromphenol is formed:
phenol with bromine
water and drops out as a
white solid?
A 2,4,6-tribromphenol
B 4-bromphenol
C 3-bromphenol
D 2,4-dibromphenol
E 2-bromphenol
41. An analyst of the Resorcinol is analysed quantitatively by bromatometry (back titration). Dissolve the
National drug quality
control
inspection substance in water; add KBr and KBrO3 solution, chloroform and hydrochloric acid.
carries out quantitative Add KI solution and titrate with sodium thiosulphate, using starch solution as indicator.
analysis of "Resorcinol"
KBrO3 + 5KBr + 6HCl → 3Br2 + 6KCl + 3H2O
substance by method of
bromatometry
(back
titration).
What
indicator is used by
doing so?
A Starch
Br2 + 2KI → I2 + 2KBr
B Ammonium iron (III)
sulfate
I2 + 2Na2S2O3 → 2NaI + Na2S4O6
C Potassium chromate
D Phenolphtalein
E Sodium eozinat
42.
An
analytical Xeroform (Xeroformium)
chemist was identifying
xeroform in reaction
with sodium sulphide.
As a result of reaction a
black solid dropped out.
What ion was detected?
A Bismuth
One of the qualitative reaction of xeroform is the reaction on Bi3+ with sodium sulphide
B Lead
– a black ppt. is formed:
C Zinc
D Copper
2Bi3+ + 3S2– → Bi2S3↓
E Silver
43. Presence of amino
group in аlanine can be
confirmed by the
reaction with:
Alanine is derivative of aliphatic amino acids:
A Ninhydrin solution
B Sulfuric acid solution
C Sulfosalicylic acid
solution
D Sodium
And all amino acids form blue-violet coloring on heating with ninhydrin:
hydrocarbonate solution
E Barium hydroxide
solution
ammonium salt of diketohydrindene
ketohydrine amine
blue-violet colouring
44. In order to identify a Among the presented pharmaceutical substances there is only one which is derivative of
drug
an
analytical aliphatic amino acids and reacts with ninhydrin. It is Methionine (Methioninum):
chemist of the State
Inspectorate for Quality
Control of Medicines
carries out the reaction
with ninhydrin solution.
Specify the drug to be The product of this reaction has a blue-violet colour, which is used for identification:
identified:
A Methionine
B Cortisone acetate
C Paracetamol
D Streptocide
E Ascorbic acid
ammonium salt of diketohydrindene
ketohydrine amine
blue-violet colouring
45. An analyst of a Paracetamol gives the reaction with FeCI3 solution (due to the phenol hydroxyl) – a
chemical
laboratory bluish-violet colouring develops:
conducts identification
of paracetamol with the
solution of iron (III)
chloride.
Blue-violet
colour
of
solution
appears in the presence
of
the
following
functional group:
A Phenol hydroxyl
B Aldehyde group
C Keto group
D Ester group
E Alcohol hydroxyl
46. For quantitative
determination of
paracetamol an analystchemist uses:
Paracetamol can be analysed quantitatively by nitritometry after preliminary acid
hydrolysis, direct titration, indicator is iodine starch paper:
A Nitritometry
B Argentometry
C Permanganatometry
D Complexometry
E Mercurimetry
47.
Pharmaceutical Procaine hydrochloride (novocaine) is synthesized by the re-esterification of ethyl
chemistry
studies
para-aminobenzoate (anesthesin) with beta-diethylaminoethanol in the presence of a
methods
of
drug
synthesis. Interaction of sodium alcoholate (an alcoholysis reaction):
anesthesin with betadiethylaminoethanol in
presence of sodium
alcoholate
with
following acidation with
anesthesin
hydrochloric acid results
in origination of:
A Procaine
hydrochloride
base of procaine
B Procainamide
hydrochloride
C Tetracaine
hydrochloride
The simultaneously formed ethanol is readily distilled off because its boiling point is
considerably lower than that of the diethylaminoethanol. The obtained base of
D Xycain
novocaine is next transformed into the chloride by the action of a calculated amount of
an alcohol solution of hydrochloric acid.
E
Trimecaine
hydrochloride
48. Which of the
mentioned below drugs
has
the
following
chemical
name:
naminobenzoic
acid
diethylaminoethyl ester
hydrochloride:
Procaine hydrochloride (Procaini hydrochloridum)
Novocaine (Novocainum)
A Novocaine
B Dimedrol
C Streptocid
D Tetracaine
According to the structural formula of novocaine we can write its chemical name: paminobenzoic acid diethylaminoethyl ester hydrochloride.
E Streptomycin
49. A pharmacy analyst
Procaine hydrochloride (Procaini hydrochloridum)
Novocaine (Novocainum)
of
an
analytical
laboratory is studying
procaine hydrochloride
according
to
the
requirements of the
Ukrainian
State According to the requirements of the Ukrainian State Pharmacopoeia the content of
Pharmacopoeia. What procaine hydrochloride is determined by nitritometry with the indicator consisting of
method is recommended tropeolin-00 mixed with methylene blue or neutral red:
by the Ukrainian State
Pharmacopoeia for the
quantitative analysis of
this preparation?
A Nitritometry
B Bromatometry
C Acidimetry
D Alkalimetry
E Chelatometry
Carry out a blank titration.
50. According to the
requirements of the
State Pharmacopoeia of
Ukraine, a pharmacy
analyst
should
determine
procaine
hydrochloride
by
nitritometric
method.
What indicator is to be
used for this purpose?
Procaine hydrochloride (Procaini hydrochloridum)
A Neutral red
B Methyl red
C Crystal violet
D Xylenol orange
E Acid chrome blue
Novocaine (Novocainum)
According to the requirements of the Ukrainian State Pharmacopoeia the content of
procaine hydrochloride is determined by nitritometry, using as a titrant 0,1 M sodium
nitrite solution with the indicator consisting of tropeolin-00 mixed with methylene blue
or neutral red:
Carry out a blank titration.
51.
A
pharmacist- According to the requirements of the Ukrainian State Pharmacopoeia the content of
analyst
carries
out procaine hydrochloride is determined by nitritometry, using as a titrant 0,1 M sodium
quantitative analysis of nitrite solution with the indicator consisting of tropeolin-00 mixed with methylene blue
procaine hydrochloride. or neutral red.
Which of the following
solutions is to be used?
A Sodium nitrite
B Sodium thiosulfate
C Sodium edetate
D Potassium bromate
E Argentum nitricum
52. An analyst of the
National drug quality
control
inspection
identifies
"Sulfametoxazol"
by
adding the solutions of
Sulfametoxazol (Sulfametoxazolum)
hydrochloric
acid,
sodium nitrite and betaDue to the presence of primary aromatic amino group sulfamethoxazol gives a reaction
naphthol
to
the
of diazotation with a following azo coupling. Sodium nitrite, HCl and β-naphthol are
preparation. An intense
added to solution of substance and an intense red colour develops (azo dye).
red colour is observed.
What functional group
is identified by this
reaction?
A Primary aromatic
amino
B Secondary aromatic
amino
C Sulpho group
D Carboxyl group
E Aldehyde group
53. Streptocide, sulfacyl Streptocide, sulfacyl sodium, norsulfazole and sulfadimezinum are sulfanylamides. The
sodium, norsulfazole or group reaction for sulfanylamides is reaction of diazotation with a following azo
sulfadimezinum can be coupling. Sodium nitrite, HCl and β-naphthol are added to solution of substance and an
identified by means of
the reaction to form:
A Azo dye
B Murexide
C Iodoform
intense red colour develops (azo dye).
D Fluorescein
E -
54.
Quantitative
Sulfadimezine (Sulfadimezinum)
analysis
of
drugs
containing
primary
aromatic amine can be
performed by means of
nitritometric
method.
Which of the following
preparations can be
Sulfadimidine
determined
by
the
nitritometric
method
Due to the presence unsubstituted primary aromatic amino group sulfadimezine can be
without preliminary acid
analyzed by nitritometry without preliminary acidic hydrolysis.
hydrolysis?
A Sulfadimidine
Nitritometry, direct titration using 0,1 M NaNO2 as a titrant, indicator – internal or
external. S=1.
B Phthalazol
C Phthazin
D Paracetamol
E Soluble streptocid
55. A pharmacy analyst
is determining one of
the following drugs by
the
nintritometric
method. What drug is
it?
A Norsulfazole
B Ftivazide
C Analgin
D Ammonium chloride
E Atropine sulfate
Norsulfazole (Norsulfazolum)
Due to the presence of primary aromatic amino group sulfamethoxazol gives a reaction
of diazotation with a following azo coupling. Sodium nitrite, HCl and β-naphthol are
added to solution of substance and an intense red colour develops (azo dye).
56. In order to identify a
drug
an
analytical
chemist of the State
Inspectorate for Quality
Control performs a
lignin test. Specify this
drug:
Lignin test is used for rapid analysis of sulfanylamides. In the result of acidic
hydrolysis of lignin aromatic aldehydes are formed that react with primary aromatic
amino group of sulfanylamides with a formation of Shiff bases. Solution of
preparation and 1 drop of HCl is put on the paper.An orange-yellow spot develops.
A Streptocid
B Ascorbic acid
C Cortisone acetate
D Methionine
E Analgin
57. A pharmacy has Biseptol (Co-trimoxazole) is a combined sulfanylamide drug which contains
sulfonamide biseptol on sulfamethoxazol and derivative of diaminopyrimidine – trimethoprim.
sale. What chemical
compounds are the main
components of this
drug?
A Sulfamethoxazole,
trimethoprim
B Sulfazin,
salazodimethoxinum
C Sulgin, norsulfazol
D Phthalazolum,
sulfadimezin
E
Urosulfan,
sulfapiridazin
58. After a sulfamide Soluble streptocide on heating with salicylic acid in presence of concentrated sulfuric
preparation was heated acid gives a crimson colour.
with salicylic acid in
presence
of
concentrated
sulfuric
acid, it turned crimson.
What drug is analyzed?
A Soluble streptocid
B Streptocid
C Sulfaguine
D Ethazol
E Phtalazol
59. An expert of an
analytical laboratory is
determining Nitrofural.
What
quantitative
titrimetric method can
be applied?
For quantitative determination of nitrofural back Iodometry in alkaline medium is used,
indicator – starch. S=1/2. The sample of preparation is dissolved on heating in water
in the measuring flask in the presence of Sodium chloride. The access of 0,01N Iodine
solution and alkali is added to some volume of solution. In alkaline medium Iodine
forms iodide and hypoiodide:
A Iodometry
B Permanganatometry
C Alkalimetry
D Argentometry
E Nitritometry
I2 + NaOH → NaI + NaIO + H2O
Iodine, which have been released after acidification is titrated by Sodium thiosulfate.
NaI + NaIO + H2SO4 → I2 + Na2SO4 + H2O
I2 + 2Na2S2O3 → 2NaI + Na2S4O6
Blank titration is carried out.
61.
Quantitative
determination
of
nitrofural (furacilin) can
be done by method of
spectrophotometry.
A
pharmacy analyst can
calculate quantity by
measuring:
One of the method of assay of nitrofural is spectrophotometry in 50% solution of
sulfuric acid.
Spectrophotometry is a physicochemical method of analysis which is based on the
determination of optical density (absorbance – A). Measured absorbance is proportional
to the pass length (b), through which radiation passes and to the concentration of
substance © in solution in accordance with aquation:
A Optical density
B Refractive index
C Rotation angle
D pH of solution
E Fusion temperature
62. Аnalgin substance Analgin (Methamizole sodium) is determined quantitatively by direct iodometry,
has been sent for indicator is starch. The solution of substance is acidified and then is titrated by Iodine
analysis. What method solution to appearance of blue color, which is not disappeared during 2 minutes. S=1.
allows
to
evaluate
quantitative content of
analgin?
A Iodometry
B Acidimetry
C Alkalimetry
D Chelatometry
E Permanganatometry
63. Which of the
following
reagents Isoniazid with a solution of copper sulfate gives a blue precipitate and a blue
should be added to the coloration, which by subsequent heating become light green, then yellowish-green
isoniazid to achieve color and gas bubbles escape:
blue
colour
and
precipitation that turns
light-green and emits
gases when heated?
A Copper sulfate
solution
B Silver nitrate solution
C Alkaline solution
D Hydrochloric acid
solution
E Iron (III)
solution
chloride
64.
In course of
Isoniazid (Isoniazidum)
isoniazid identification a
pharmacy analyst boiled
thoroughly
the
substance with 2,4dinitrochlorobenzene.
The substance turned
yellow, after adding
alkaline solution it Isoniazid contains in its structure pyridine cycle, which can be determined with 2,4turned first violet and dinitrochlorobenzene. The substance turns to yellow, after adding alkaline solution it
then brownish-red. As a turns first to violet and then to brownish-red due to formation of glutaconic aldehyde:
result of this reaction
the following aldehyde
derivative
is
produced:
A Glutaconic
B Gluconic
C Glutamic
D Glyoxylic
E Hexanic
65. Phthorafurum is
used for treatment of
gastric and intestinal
cancer. Fluorine in
phthorafurum
is
detected
after
mineralization by the
reaction with:
Fluorafur (Phthorafurum)
Tegafur
A Calcium chloride
BAmmonium hydroxide
C Potassium nitrate
D Sodium carbonate
Fluorine in phthorafurum is identified after mineralization by the reaction with CaCl2:
E Potassium chloride
white opalescence
66. According to the
requirements of the
State Pharmacopoeia of
Ukraine, a pharmacy
analyst
should
determine fluorouracil
by
method
of
nonaqueous
titration.
What titrated solution is
to be used?
Pharmacopoeian method of assay of fluorouracil is alkalimetry in non-aqueous media,
direct titration, indicator – thymol blue, S=1. As a titrant a solution of
tetrabuthylammonium hydroxide in DMFA medium is used. Blank titration is carried
out.
A Tetrabutyl ammonium
hydroxide
B Sodium nitrite
C Potassium bromate
D Ammonium
thiocyanate
E Sodium edetate
67. A chemist identifies
ofloxacin after
mineralization by the
reaction of:
Ofloxacin is chemotherapeutic agent which belongs to the group of fluoroquinolones. It
contains F- ion which can be identified after mineralization.
Ofloxacin (Ofloxacinum)
A fluorides
B sulphates
C arsenites
D phosphates
E sulphides
68. When the glucose is Due to the presence of aldehyde group glucose gives a brick-red precipitate on heating
heated with the copper- with copper-tartrate reagent (Fehling's reagent):
tartrate reagent
(Fehling's reagent) the
brick-red precipitate
settles down. It indicates
presence of the
following group:
A Aldehyde
B Ketonic
C Carboxyl
D Etherific
E Amide
69.
In order to verify Vitali test: to a substance examined a fuming nitric acid is added and evaporated to
identity
of
tropan dryness in a water-bath. The residue is dissolved in acetone and a solution of potassium
derivatives,
Vitali's hydroxide in methanol is added. A violet colour develops:
reaction is applied. For
that
purpose
the
medications should be
first decomposed with
nitric acid and then
treated with alcoholic
solution of potassium
hydroxide and acetone.
What effect will be
observed?
A The solution will turn
purple
B The solution will turn
green
C Emission of gas
bubbles
D Setting of black
precipitate
E Setting of white
precipitate
70. Codeine can be Codeine is opium alkaloid whiсh can be obtained by semisynthetic method from
derived for medical morphine:
purposes out of a plant
alkaloid by means of
semisynthetic method.
Name this alkaloid:
A Morphine
B Papaverine
C Berberine
D Protopine
E Chelidonine
Preparations of quinine Talleioquine is a product of interaction of quinine with bromine water and dilute
are
identified
with ammonia. In result of this reaction a green colour develops:
bromine water and
solution of ammonia
according to formation
of specific product of
reaction. Name this
product:
A Talleioquine
B Murexide
C Iodoform
D Ferric Nhydroxyacethamide
E Methylglyoxal
71.
An
analytical Non-aqueous titration in the medium of a mixture of acetic acid and acetic anhydride is
chemist determines the used for quantification of caffeine. 0,1 M solution of perchloric acid is used as a titrant,
quantitative content of the end-point is determined potentiometrically; S=1.
caffeine by method of
acidometry
in
nonaqueous media in
compliance with the
State Pharmacopoeia of
Ukraine. What solution
is used as a titrant?
A Perchloric acid
B Sodium edetate
C Potassium bromate
D Sodium hydroxide
E Sodium nitrite
72. Theobromine and Indirect alkalimetry is used for quantitative determination of theobromine and
theophylline can be theophylline. After addition of 0,1 M AgNO3 solution a nitric acid is formed which is
determined
by titrated by 0,1 M NaOH, an indicator is bromothymol blue. S=1.
alkalimetric
method
according
to
the
substituent. What acid is
to be titrated with
sodium hydroxide?
A Nitric
B Chydrochloric
C Sulfuric
D Acetic
E Phosphoric
73.
Solution
of
ephedrine hydrochloride
in ampules was received In reaction of ephedrine hydrochloride with potassium (ІІІ) ferricyanide an odour of
for analysis in a control- benzaldehyde appears:
analytical
laboratory.
One of reactions of
identification
of
preparation
is
the
reaction with solution
of. What appears?
A The
smell
benzaldehyde
of
B Bubbles of gas
C Black precipitate
D The smell of
ammonium
E Black colour
74.
Due
to
the Due to the requirements of Ukrainian State Pharmacopoeia and Eur. Ph. ascorbic acid
requirements of State is determined with silver nitrate solution – a dark grey precipitate is formed.
Pharmacopoeia
of
Ukraine the analystpharmacist
conducts
identification
of
ascorbic acid with the
use of reagent:
A Silver nitrate
B Zinc sulphate
C Ammonium oxalate
D Calcium chloride
E Barium nitrate
75.
Analytical
laboratories oten use
Ascorbic acid discharges a blue colour of 2,6-dichlorophenolindophenol solution:
2,6dichlorophenolindophen
ol solution, which is
normally blue and can
be decolourized by the
reducing agents. What
drug can be identified
by means of 2,6dichlorophenolindophen
ol solution?
A Ascorbic acid
B Salicylic acid
C Nicotinic acid
D Benzoic acid
E Acetylsalicylic acid
76.
Substance
of Calcium cation forms a white precipitate with Ammonium oxalate a white precipitate,
calcium pangamate is to which dissolves in mineral acids:
be
studied
in
n
analytical
laboratory.
Calcium cation forms a
white precipitate with
the following reagent:
A Ammonium oxalate
B Sodium chloride
C Potassium
permanganate
D Potassium bromide
E Sodium cobaltinitrite
77.
The
analyst
pharmacy The solution of riboflavin (vitamin B2) in the transmitted light has a pale greenishidentifies yellow color, and in reflected light it shows an intense yellowish-green fluorescence,
vitamins eye drops. At which disappears on the addition of mineral acids or alkali.
consideration in UVlight
a
bright After adding of sodium hydrogen sulphite the fluorescence and color of the solution
disappear:
yellowish-green
fluorescence
is
observed. It testifies the
presence of:
A Riboflavin
B Thiamine bromide
C Folic acid
D Ascorbic acid
E Vicasolum
78. The presence of Due to the presence of phenyl hydroxyl pyridoxine reacts with iron (III) chloride. A
what functional group in red colour develops.
the
molecule
of
pyridoxine
hydrochloride gives a
possibility to pass a
reaction with the iron
(III) chloride?
A Phenyl hydroxyl
B Carboxyl group
C Aldehydic group
D Alcoholic hydroxyl
E Pyridine cycle
79. Which of the
following drugs can be
quantified
by
an
analytical chemist by
ceriometry method?
Ceriometry (direct titration) is used for quantitative determination of Vicasolum
(vitamin K). After interaction with sodium hydroxide 2-methyl-1,4dioxynaphthoquinone is formed, then it is reduced to 2-methyl-1,4-dioxynaphthalin,
which is titrated with 0,1 M cerium sulphate to green colour (the indicatior is ferroine).
A Vicasolum
B Acetylsalicylic acid
C Sodium benzoate
D Phenyl salycylate
E Phenobarbital
S=1/2.
80.
An
analytical According to the requirements of the Ukrainian State Pharmacopoeia, quantitative
laboratory
received analysis of Adrenaline tartrate is carried out by acidimetry in non-aqueous medium
"Adrenalini
tartras" using as a titrant 0,1 M perchloric acid solution, indicator is crystal violet. S=1.
substance for analysis.
According
to
the
requirements of the
Ukrainian
State
Pharmacopoeia,
quantitative analysis of
this substance can be
carried out by method
of:
A Acidimetry in nonaqueous medium
B Acidimetry in
aqueous medium
C Iodometry
D Nitritometry
E Bromatometry
81.
A
pharmacist- According to the requirements of the Ukrainian State Pharmacopoeia, quantitative
analyst is measuring the analysis of Adrenaline tartrate is carried out by acidimetry in non-aqueous medium
quantity
of
an using as a titrant 0,1 M perchloric acid solution, indicator is crystal violet. S=1.
adrenaline
tartrate
substance by method of
acid-base titration in
nonaqueous
solvents.
Which indicator is to be
used in this case
according
to
the
requirements of the
Ukrainian
State
Pharmacopoeia?
A Crystal violet
B Methyl orange
C Phenolphtalein
D Thymolphthalein
E Eriochrome black
82. According to the Magnesium impurities are determined by reaction with 8-hydroxyquinoline in
State Pharmacopoeia of chloroform. An intense yellow colour of solution must be not more intense than of
Ukraine, in order to test reference (standart) solution.
a substance for the
highest
level of
magnesium impurities
an analytical chemist
must use the following
solution:
A Hydroxyquinoline
B Resorcin
C Pyridine
D Formaldehyde
E Benzaldehyde
83. In order to identify Ouabain (strophanthine G)belongs to the group of cardiac glycosides. Cardiac
ouabain (strophanthine glycosides have in their base a steroid cycle, which is determined by the reaction with
G), a drug from the sulfuric acid.
group
of
cardiac
glycosides, an analytical
chemist must prove the
presence of a steroid
cycle. What acid should
be used as a reagent?
A Sulfuric
B Oxalic
C Citric
D Formic
E Chromotropic
84. The basic structure Testosterone propionate (Testosteroni propionas)
of steroid hormones is
hydrocarbon skeleton cyclopentane
perhydrophenanthrene.
What natural compound
is used for testosterone
propionate production?
A Cholesterol
B Indole
Testosterone is an androgen steroid hormone. In the body the cholesterol is used for its
production.
C Naphthalene
D Phenanthrene
E Anthracene
85. An analytical chemist working at a pharmacy
identifies oxacillin sodium salt. As a reagent he uses
hydroxylamine hydrochloride solution in presence of
sodium hydroxide solution and copper nitrate
solution. What structural fragment of a drug
molecule can be detected by means of these
reagents?
Oxacillin sodium belongs to β-lactam antibiotics. Due to
the presence of
β-lactam cycle it reacts with
hydroxylamine hydrochloride solution in presence of
sodium hydroxide solution and copper or iron salts. In
case of formation of copper penicillino-hydroxamate a
green colour develops, when iron
penicillinohydroxamate is formed a red colour develops:
A Beta-lactam cycle
B Thiazolidine cycle
C Isoxazole cycle
D Furan cycle
E Thiadiazole cycle
86. A base of the structure of tetracycline is partly
hydrated ring of:
A partly hydrated naphthacene (tetracene) ring is in the
base of tetracycline.
A Naphthacene
B Naphthalene
C Acridine
D Phenanthrene
E Anthracene
Tetracycline (Tetracyclinum)