CSL Limited, (Parkville, Australia) ABN 99 051 588 348
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Position Title:
Research Scientist – ISCOMATRIX Adjuvant Research
Department:
828
Division:
R&D
CSL Level:
CSL5
Employment Type:
Full Time
Summary of Role:
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The objective of the group is to develop, validate and perform key immunological assays
using recombinant protein therapeutics such as vaccines, antibodies and other protein
mediators that target and modulate the function of specific cell types and ameliorate
diseases. This particular role within the Cell Biology and Physiology group is responsible for
the physical and chemical characterisation and assay development of ISCOPREP™ saponin
and ISCOMATRIX™ adjuvant. The role extends the capabilities of the group by providing
expertise in physical chemistry (specifically surface chemistry) and analytical chemistry of
ISCOPREP™ saponin and ISCOMATRIX™ adjuvant. Further, the role adds capability in
chemical modification ISCOPREP™ saponin contributing to the elucidation of the mechanism
of action of ISCOMATRIX™ adjuvant.
Reporting Structure:
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Role that this position reports to: CSL 6 Senior Scientist: ISCOMATRIX® adjuvant Research
Chemistry group.
Role/s that report to this position: CSL 3 Junior Scientist
RESPONSIBILITIES
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Design and performance of laboratory experimentation
Contribute to the development, formulation and evaluation of ISCOMATRIX® adjuvant-based
therapeutic candidates
Developing analytical methods and writing protocols suitable for assay, release qualification,
and product characterisation studies
Develop and perform A4F MALS assays on potential ISCOMATRIX® adjuvant-based
therapeutic candidates
Develop and perform HPLC assays on potential ISCOMATRIX® adjuvant-based therapeutic
candidates
Develop and perform Capillary Electrophoresis assays on potential ISCOMATRIX® adjuvantbased therapeutic candidates
Develop and perform ESI LC-MS assays on potential ISCOMATRIX® adjuvant-based
therapeutic candidates
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Investigate the physical structure of ISCOMATRIX™ adjuvant
Perform HPLC data analysis using Waters EMPOWER and Agilent Chemstation software
Prepare experimental protocols, scientific reports and SOPs as required
Maintaining records of all laboratory work to Good Scientific Practice (GSP) standards
Present scientific data at Departmental level, project team level and externally as required
Assist colleagues in the laboratory to carry out experiments
Comply with HS&E guidelines as appropriate
Key Relationships (both internal and external)
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Senior Scientist, ISCOMATRIX® adjuvant Research (Poplar Road)
Junior Scientist, ISCOMATRIX™ adjuvant research (Poplar Road)
Group Leader, ISCOMATRIX® adjuvant Research (Bio 21)
Team members, ISCOMATRIX® adjuvant Research (Bio 21)
Members of Cell Biology and Physiology Group (Bio21)
Head, Cell Biology and Physiology Department (Bio 21)
Members of Research Division (Bio21)
Senior Project manager, ISCOMATRIX™ adjuvant technology (Poplar Road)
Project Leaders
Job Environment
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Ground floor laboratory, Building 10, Parkville
Working hours, 7.35 hours/day, 10 day fortnight
Attendance to one local or interstate or international conference as required
Work within a team as well as independently on various ISCOMATRIX® adjuvant based
technologies
POSITION SPECIFICATION
Essential Qualifications/Experience:
 Tertiary degree in Physical Chemistry or Analytical Chemistry with at least 5 years experience
Essential Skills, Knowledge & Attributes:
 Expertise in Physical Chemistry with particular emphasis on Surface Chemistry
 Expertise in Asymmetric Flow Field-Flow Fractionation (A4F) and Multi Angle Laser Light
Scattering (MALS)
 Experience in HPLC method development and analysis
 Experience in Electrospray Ionization Mass Spectrometry (ESI-MS)
 Experience in HPLC-MS
 Experience in Capillary Electrophoresis
 Experience in writing scientific reports
 Good computer skills
 Proficiency in the use of expert scientific software (EMPOWER, Chemstation, Masslynx,
Astra)
 Knowledge of GSP/GLP/GMP requirements for pharmaceutical manufacture
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APPROVAL TABLE (Mandatory)
Title
Name
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Date
Head, Cell Biology
and Physiology
Eugene Maraskovsky
/
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Director of Research
Andrew Nash
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Effective
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3 Years
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