CSL Limited, (Parkville, Australia) ABN 99 051 588 348
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Position Title:
Research Scientist – ISCOMATRIX Adjuvant Research
Department:
828
Division:
R&D
CSL Level:
CSL5
Employment Type:
Full Time
Summary of Role:
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This role within the Cell Biology and Physiology group is responsible for evaluating novel
vaccine strategies and other protein-based therapeutics utilizing the ISCOMATRIX® adjuvant.
The objective of the group is to develop, validate and perform key immunological assays
using recombinant protein therapeutics such as vaccines, antibodies and other protein
mediators that target and modulate the function of specific cell types and ameliorate
diseases. In addition, the role requires that the therapeutic candidates be evaluated in
animal models of disease (e.g. tumour, inflammation, autoimmunity) in order to identify the
mechanisms of action of the therapeutic strategies.
Reporting Structure:
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Role that this position reports to: CSL 6 Group Leader: ISCOMATRIX® adjuvant Research
Role/s that report to this position: none
RESPONSIBILITIES
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Participate in the development, formulation and evaluation of ISCOMATRIX® adjuvant-based
therapeutic candidates
Develop and perform in vitro screening assays to identify potential ISCOMATRIX® adjuvantbased therapeutic candidates
Develop and perform flow cytometry based assays to evaluate cytokine production, cell
death, cell signalling
Develop and perform animal models of disease for in vivo evaluation of potential therapeutic
candidates
Investigate modes of action of potential therapeutic candidates
Perform data analysis using routine spreadsheet and graphing platforms and flow cytometry
software (FlowJo, Cell Quest, DIVA)
Prepare experimental protocols, scientific reports and SOPs as required
Present scientific data at Departmental level, project team level and externally as required
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Assist senior personnel in the laboratory to carry out experiments
Organization and maintenance of lab records
Comply with HS&E guidelines as appropriate
Key Relationships (both internal and external)
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Group Leader, ISCOMATRIX® adjuvant Research (Bio 21)
Team members, ISCOMATRIX® adjuvant Research (Bio 21)
Members of Cell Biology and Physiology Group (Bio21)
Head Cell Biology and Physiology (Bio 21)
Members of Research Group (Bio21)
Project Leaders
Job Environment
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Cellular Biology laboratories and mouse facilities at Bio 21
Working hours (10 day fortnight with occasional overtime and weekend work as required)
Attendance to one local or interstate or international conference as required
Work within a team as well as independently on various ISCOMATRIX® adjuvant-based
therapeutic candidates
POSITION SPECIFICATION
Essential Qualifications/Experience:
 Tertiary degree in biological science with at least 5 years experience
Essential Skills, Knowledge & Attributes:
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Experience in immunological techniques for assessing leukocyte function in vivo
Experience in vaccine formulations and animal models of disease
Experience in animal tumour models (syngeneic and xenografts, solid and metastatic)
Experience in cell culture and aseptic technique
Experience in flow cytometry
Experience in assay development and validation
Experience in writing scientific reports
Good computer skills in Macintosh and PC.
Proficiency in the use of Microsoft Office programs and Flow Cytometry Analysis programs
 Knowledge of GLP requirements for pharmaceutical manufacture
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DOCUMENT CROSS REFERENCE
Document Cross Reference table internal and external documents
[References should include document/s that this document is to be linked to, has been derived from and
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DOCUMENT HISTORY [Mandatory]
[List the current edition and previous two editions to the document]
Edition
Effective
Date
Prepared by/Author
Change Control
No
Description of Change
APPROVAL TABLE (Mandatory)
Title
Name
Signature
Date
Head, Cell Biology
and Physiology
Eugene Maraskovsky
/
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Director of Research
Andrew Nash
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/
Effective
/
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/
Review period:
3 Years
Prepared by/Author
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