HAP Final Exam Study Guide: Review old tests and quizzes! Day 1 Test What is the difference between anatomy and physiology? Anatomy = Structure Physiology = Function Know directional terms and be able to use them properly Medial/lateral = Toward the midline/Away from the midline Proximal/distal = Arms and Legs ONLY Toward the point of attachment/Away from the point of attachment Superior/inferior = Toward the top of the body/Toward the feet Anterior/posterior = Toward the front of the body (ventral)/Toward the back of the body (dorsal) Superficial/deep = Toward the surface/Away from the surface What is homeostasis? Ability to maintain balance in the body as situations change. What is a deficit or defect in homeostasis called? Disease Negative and Positive Feedback Negative Feedback reverses the initial stimulus Positive Feedback exaggerates the initial stimulus The chemical behavior of an atom is determined by: The number of outer shell electrons Structure of an atom including protons, neutrons, electrons Protons have a positive charge and are found in the nucleus, Electrons have a negative charge and orbit the nucleus, Neutrons have no charge and are found in the nucleus Why do atoms make bonds? To fill their outer shells Provide examples of inorganic/organic compounds. Inorganic compounds lack carbon and are relatively small; Example: Water, ions Organic compounds contain carbon and are very large in comparison to inorganic compounds; Ex: Proteins, Carbs, Lipids, Nucleic acids What are the 4 main classification of organic macromolecules and their basic functions? Carbohydrates: monomer – monosaccharides/glucose Proteins: monomer – amino acids Lipids: monomer – none Nucleic acids: monomer – nucleotide function – energy function – variety function – cell membrane structure, energy, hormones function – DNA: code for proteins, RNA: make proteins, ATP: energy conversion What is a monomer/polymer? What is significant about monomers and polymers? Monomer is a building block; Polymer is a long chain. The idea is that you break down polymers to get monomers to make more polymers. What are the biological functions of proteins? STATEMENT: Enzymes speed up chemical reactions without being consumed during the reaction. All enzymes are proteins and act as catalysts. All enzymes are proteins, hormone function, structure, clot formation Describe the segments of the Cell Cycle Clock and their functions in maintaining the cell life cycle. G1 and G2 = growth and work; S = DNA replication; M = mitosis and cytokinesis; G0 = Quiescence = WORK What are the four main tissue types and their functions? Be specific with muscles and some connective tissues. Epithelial = lines internal and external body cavities Connective = variety of functions/broadest category Muscle = movement Nervous = move electrical impulses What are the 4 main structural categories of bones? Provide an example of a bone in each category. Long = femur, radius, phalanges Short = carpals and tarsals Flat = parietal and sternum Irregular = vertebrae, mandible Fontanels allow for what to occur to the skull? Flexibility for childbirth and expansion for brain growth What makes muscle fibers (cells) different from other body cells? Multinucleated; undergoes mitosis but not cytokinesis; elongated What ingredients are necessary for normal muscle contraction to occur? Oxygen, glucose, electrolytes, water, and a good blood supply What are the 3 main varieties of muscle tissue? Skeletal, smooth, and cardiac As muscles use energy reserves and begin to produce lactic acid, the muscle has entered a state of: fatigue The nervous system communicates with the muscle fiber at this location: Neuromuscular junction The functional unit of the skeletal muscle is known as the: Sarcomere – from Z-line to Z-line The collagen bundles at the end of the skeletal muscle that attaches to bone are the: tendon What are the origin and insertion of each muscle referring to? Origin is the unmoving anchor Insertion is on the moving bone STATEMENT: Understand the rules for naming muscles that allow for ease in identification. What is the basic functional unit of the nervous system? Neuron Know the basic structure of a typical neuron. Dendrite, cell body, axon, synapse (gap) Know the 4 main structural classification of neurons based on presence/absence of dendrite(s) and axon. Unipolar – one continuous dendrite-axon extension and cell body off to the side Bipolar – one dendrite and one axon with cell body in the center Multipolar –several dendrites and one long axon with cell body in the center Anaxonic – several dendrites and one axon that all look the same around a central cell body location – senses for touch location – sight, smell, hearing location – brain for networks location – brain for networks Know where each type of neuron is most commonly found according to function. See above What neuron type is most common in the CNS? Multipolar – good at forming networks What are the types of neuroglia found in the CNS? Astrocytes – scaffolds Microglia – white blood cells/phagocytes Oligodendrocytes – insulators Ependymal cells –make CSF The most common neuroglia found in the CNS are: astrocytes What is the difference between the CNS and PNS? CNS = Central nervous system – control center PNS – Peripheral nervous system – receptors and effectors What is the difference between the sympathetic and parasympathetic nervous system? Sympathetic – flight or flight response Parasympathetic – resting and digesting response Know the main anatomical regions and structures of the eye. The central opening in the eye that allows light to enter: pupil The portion of the eye that contains pigment: iris The cornea is the transparent outer covering of the eye. How can we classify vision problems? Know the following terms: Emmetropia: perfect vision Myopia: near-sighted Hyperopia: far-sighted Presbyopia: aging eyes Glaucoma: increased intraocular pressure Astigmatism: abnormality of the cornea Day 2 Test What does endocrine mean? Exocrine? Endocrine releases substance into blood or body fluid; stays inside the body Exocrine release substance into structure that will exit the body STATEMENT: Know the difference between the function of steroid and protein hormones. Which can enter the cell and nuclear membrane? Which must use the second messenger system? Which directs gene activation? Why is there a difference in their functions? Describe the term hypersecretion and hyposecretion. Hyper = too much Hypo = too little How are hormones stimulated to be released? Neural stimulation of a hormone? Release triggered by the nervous system Humoral stimulation of a hormone? Release triggered by blood levels of substances Hormonal stimulation of a hormone? Release triggered by the release of another (trophic) hormone What 4 hormones are necessary for reproduction to occur? FSH, LH, estrogen, and testosterone What is/are the functions of the reproductive system? To produce offspring On average, how many eggs are found in the ovaries of a newborn female? About 100,000 eggs total What is the average sperm count/5 mL of fluid? About 300 million sperm How many chromosomes are found in somatic (body) cells of humans?/Gametes? Somatic chromosome # = 23 pairs/46 total Gamete = 23 single chromosomes What structure transports the ovum to the uterus? Fallopian tube In what order of structures do the sperm travel to exit the male reproductive tract? Epididymis, vas deferens, ejaculatory duct, urethra Where should fertilization of an egg normally occur? Fertilization should occur in the fallopian tube What is an ectopic pregnancy? Implantation of a fertilized egg outside of the uterus Know the composition of whole blood. Whole blood is made of plasma, buffy coat, and packed red cells Know the functions of each formed element in blood. Erythrocytes are red blood cells that transport oxygen Thrombocytes are platelets that help form clots Leukocytes are white blood cells that perform immune functions What products can be found dissolved in plasma? Water, nutrients, wastes, clotting factors, electrolytes, enzymes, hormones What hormone regulates blood cell production? erythropoetin Describe how blood transfusions result in DIC (disseminated intravascular coagulation). Antibodies in the patient plasma bind to antigens on the surface of the donates RBC’s causing the blood to form clots Describe the appearance of A, B, and Rh antigens on the red cell surface. A blood has A antigens on the RBC surface and B antibodies in the plasma B blood has B antigens on the RBC surface and A antibodies in the plasma AB blood has A and B antigens on the RBC surface and no antibodies in plasma O blood lack A and B antigens on the RBC surface and both A and B antibodies in plasma Where does blood cell production take place? Bone marrow Stem cell production pathway for blood cell lines Hemocytoblast? Forms all blood cells Lymphoid cell line? Forms lymphocytes and monocytes Myeloid cell line? Forms Erythrocytes, platelets, neutrophils, Eosinophils, and Basophils What is Hemostasis? Stoppage of blood flow What are the phases of Hemostasis? Vascular spasm, platelets clot formation, fibrin clot formation Be able to identify chambers of heart, including left vs. right and oxygen-rich vs. oxygen-poor. Know valves between chambers (AV valves) and valves between ventricles and arteries (SLV’s) and where the valves/arteries lead when exiting the ventricles. Describe systemic and pulmonary circulation. Systemic – left ventricle to body cells to right atrium Pulmonary – right ventricle to lungs to left atrium Differences between arteries, arterioles, capillaries, venules, and veins. Arteries leave the heart and are large, they get smaller and become arterioles, capillaries are the smallest and allow for exchange of gases and nutrients, venules collect blood from capillaries and become large veins that enter the heart Describe fetal circulation in relation to circulation after birth. Important structures: Foramen ovale: between L and R atrium; allows blood to bypass the lungs since non-functional Ductus arteriosus: between pulmonary trunk and L atrium; allows blood to bypass the heart What factors can influence heart rate and cardiac output? Diet, age, exercise, genetics, environment What factors influence blood pressure? Same What are the 2 main functions of the respiratory system? Gas exchange and to warm, moisten, and filter air as it enters the lungs What are tonsils? What is their function? Where are they located? Tonsils are lymph nodes that filter impurities from the blood and protect/guard the sinuses and lungs Explain the processes of breathing, external, and internal respiration. Breathing is the movement of gases into and out of the lungs External respiration is movement of gases between the lungs and the blood Internal respiration is the movement of gases between the blood and body cells