Medical University of Vienna (MUW)
Computer Simulation in Immunology
Contact person details
Name:
SCHREINER , Wolfgang ( Professor, Dr)
Name of
Organisation:
Medical University of Vienna (MUW)
URL:
E-mail:
Contact
Telephone:
+43-1-40400 6679
Fax number:
+43-1-40400 6677
Collaboration
Type: Company Expertise
Title: Computer Simulation in Immunology
Participation: Type A
Type Details: Our expertise is in modelling and computer simulation for
immunology. So far, one of our main targets are the T-cell receptor interaction and
activation models, for which we are simulating epitope recognition leading to TCR
activation.
We use molecular dynamics of MHC-epitope interaction and the docking of TCRs to
pMHC complexes for our findings. The simulation shows the induced structural
changes in TCR depending on epitope recognition.
Our research provides insight into molecular mechanisms in several other fields of
research as well, such as
- Immune therapy in oncology
- Allergolgy
- Autoimmune diseases
- Transplant tolerance and rejection
- Virtual screening of potential ligands for various kinds of receptors
Programme: FP7-HEALTH
Instruments: CP-FP Small or medium-scale focused research project,CP-TP
Collaborative Project targeted to a special group (such as SMEs),MC-IAPP IndustryAcademia Partnerships and Pathways (IAPP)
Research interest:
Expiry Date: 2009-04-17
Workprogramme area(s)/key action(s):
Target Partner
Expertise:
We search for partners coordinating EU projects involving expertise in the following
areas:
1.)
Parners with biomedical expertise in wet-lab experiments in the field of immunology.
These partners may suggest interesting molecular mechanisms for which we perform
a virtual screening using our computational tools. The screening may comprise
docking processes, evaluation of structural deformation and molecular signalling. The
molecular mechanisms to be screend may either pertain to experimental settings or
patient studies. Virtual screening by our group may drastically reduce potential sets
of molecules to be investigated by wet-lab methods or patient studies, therby
reducing project costs and focussing more efficiently on promising targets.
2.)
We are also looking for technical partners coordinating EU projects who are
specialized in computational tools and / or skills.
Our projects in virtual screening require massive computational power only found in
computational grids or clusters on the basis of SMP systems.
For anyone running or developing such a super computer environment and coording
a respective EU project we can provide biomedical projects of ultimate relevance.
Country: Any country
Organization Details
Name:
Medical University of Vienna (MUW)
Department:
Medical Statistics and Informatics, Biomedical Computer
Simulation
Address:
Core Unit for Medical Statistics and Informatics
A-1090
Vienna
ÖSTERREICH
Type:
Research
Number of
Employees:
50 - 249
Details:
SIC Codes:
Life Sciences , Medical biotechnology , Medicine, Health
Keywords:
immunology
computer simulation
modelling
bioinformatics
molecular dynamics
epitope
immunogenicity
in-silico
Partners already
acquired:
Austrian Grid Consortium, AUSTRIA
Univ.Prof. Dr. Rudolf Valenta, Medical University Vienna,
Department of Pathophysiologie, AUSTRIA
Univ.Doz. Dipl.-Ing. Dr. Barbara Bohle, Medical University
Vienna, Department of Pathophysiologie, AUSTRIA
Dr. Martin Neumann, University of Vienna, Department of
Computational Physics, AUSTRIA
Univ.-Prof. Dr. Othmar Steinhauser, University of Vienna,
Department of Biomolecular Structural Chemistry, AUSTRIA
Dipl.-Ing. Dr. Hannes Stockinger, Medical University Vienna,
Department of Molecular Immunology
Univ.Prof. Dr. Gerhard-Johann Zlabinger, Medical University
Vienna, Department of Immunology