CHML 211
Lab Quiz 2 Study Guide
Summer 2009
***YOU MUST BRING YOUR OWN
CALCULATOR TO THE EXAM!***
Exp. 3: Stereochemistry and Molecular Modeling:
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Be able to identify which form is more stable given different conformations of disubstituted
cyclohexanes.
Be able to identify the spatial relationship of methyl substituents as cis ortrans.
Be familiar with the individual types of energy that contribute to the overall steric energy of a
molecule.
Be familiar with LAB REPORT QUESTIONS and READ THE EXPERIMENT AGAIN!
Exp. 5: Column Chromatographic Separation of Nitroanilines
 Be able to predict the order of elution of compounds in column chromatography and HPLC based
on analyte polarity.
 Understand the effect of changing the solvent system polarity on the HPLC retention times and
column elution rates of compounds.
 Be able to comment on purity given an HPLC chromatogram.
 Be familiar with LAB REPORT QUESTIONS and READ THE EXPERIMENT AGAIN!
Exp. 6: The Extraction of Analgesics:
 Be familiar with the *SPECIFIC* reagents used in acid-base extraction to separate aspirin from
acetaminophen.
 Be able to calculate % recovery given initial and final weights of components.
 Understand how TLC and HPLC analysis can be used to determine purity and identity of
substances.
 Be able to identify which compounds were isolated in which layers during the extraction process.
 Be familiar with LAB REPORT QUESTIONS and READ THE EXPERIMENT AGAIN!
Exp. 7: Recrystallization, Melting Point, and HPLC of Analgesics:
 Be able to list the main steps of a recrystallization experiment.
 Understand how a recrystallization process purifies a substance.
 Know the effect of an impurity on the experimental melting point of a substance.
 Know the characteristics of an ideal solvent for a recrystallization method.
 Be familiar with LAB REPORT QUESTIONS and READ THE EXPERIMENT AGAIN!
Exp. 8: Bromination of Stilbene: A Green Chemistry Experiment:
 Be familiar with the mechanism for the bromination of an alkene.
 Be able to draw the structure on the bromonium intermediate and name a product given
reactants.
 Be able to calculate theoretical and percent yield.
 Be familiar with LAB REPORT QUESTIONS and READ THE EXPERIMENT AGAIN!