Licensing Opportunity
from the University of Rhode Island
Oxazole and Thiazole Combinatorial Libraries
Description of Invention: This invention provides a novel method for synthesizing an ensemble of
peptides that allows for the generation of an unlimited number of antibiotic compounds. More specifically, the
method comprises utilizes synthetic heterocyclic amino acids containing thaizole and/or oxazole as building
blocks in a solid phase combinatorial synthesis to yield natural and unnatural antibiotic compounds.
Potential Areas of Application:
1) This invention relates to the syntheses of thiazole and/or oxazole-containing amino acids and more
specifically to the use of those compounds in a combinatorial synthesis to generate antibiotic
compounds.
2) More and more thiazole and/or oxazole-containing peptides with important biological activities such
as antitumor, antifungal, antibiotic, and antiviral activities have been found from microbial and marine
origins. It seems that the thiazole and oxazole ring systems might be important pharmacophores in
those biologically active compounds.
Main Advantages of Invention:
1) Broadly this invention is directed toward a novel method for synthesizing an ensemble of peptides
that allows for the generation of an unlimited number of antibiotic compounds. The compounds
synthesized find utility in inhibiting DNA replication or DNA transcription in cancer cells, pathogenic
cells such as bacteria, and virally infected cells.
2) The invention utilizes synthetic unnatural heterocyclic amino acids as building blocks in a solid phase
combinatorial synthesis. More specifically, this invention is directed toward combining synthetic
heterocyclic amino acids containing thiazole and/ or oxazole as building blocks in the synthesis of
combinatorial libraries.
Lead Inventor:
Lenore M. Martin et al, CELS
Status:
US patent application 11/266,046 filed November 3, 2005
Oxazole and Thiazole USPTO Website Link
Publications (with links):
Category: Biological, Pharmaceutical, Life Sciences
Licensing Status:
Available for licensing
Reference #:4705
Please contact David R. Sadowski or Raymond Walsh - Division of Research & Economic Development, University of Rhode Island,
75 Lower College Rd. Suite 001, Kingston, RI 02881; 401-874-4807 or Fax 401-874-7832
http://www.uri.edu/research/tro/executive/sadowski.html
Rev. 01-14-10