15th Beaune Seminar in Transplant Research
21-22 May 2015
Programme
Cellules B et anticorps en transplantation
B cells and antibodies in transplantation
Thursday 21 May
8.15-8.30
Everything you always wanted to know about antibodies in
transplantation
Christophe MARIAT (Saint Etienne, France)
B cells and antibodies, where do they come from?
8.30-9.00
Early events of B cell differentiation and activation.
Olivier THAUNAT (Lyon, France)
9.15-9.45
Immune regulation by regulatory B cells: a new paradigm.
Sushma SHANKAR (Oxford, UK)]
10.00-10.30
A guided tour in plasma cell niche: long-term survival of plasma cells.
Claudia BEREK (Berlin, Germany)
10.45-11.00 Coffee break
Structure and function of antibodies
11.00-11.30
Life and death of antibodies
Henri WATIER (Tours, France)
11.45-12.15
Sialylated IgG: a sweet remedy for inflammatory diseases?
Falk NIMMERJAHN (Erlangen-Nürnberg, Germany)
12.30-13.45 LUNCH
13.45-14.15
Catalytic antibodies in auto and alloimmunity
Sébastien LACROIX-DESMAZES (Paris, France)
14.30-15.00
IgG Fc-derived Treg Epitopes (Tregitopes)
Annie DE GROOT (Providence, USA)
Antibodies and graft rejection or acceptance
15.15-15.45
Anti-HLA antibody binding trigger endothelial cell signaling: molecular
pathways and functional consequences
Elaine REED (Los Angeles, USA)
Discussion: Nuala MOONEY (Paris, France): HLA class II
mediated mechanisms of damage: T and endothelial cell activation
16.15-16.30 Coffee break
16.30-17.00
Non-HLA antibodies
Minnie SARWAL (San Francisco, USA)
17.15-17.45
The concepts of accommodation and enhancing antibodies
Lori WEST (Edmonton, Canada)
18.00-18.30
Master Challenge: oral presentation of the 2 best abstracts (10+5mn
each).
Friday 22 May
8.45-9.15
Biological challenge(s) in alloantibody detection
Jean-Luc TAUPIN (Bordeaux, France)
Discussion: Laurent MARTIN (Dijon, France)
9.30-10.00
Clinical challenge: stratification of the risk of antibodies-mediated graft
failure
Alexandre LOUPY (Paris, France)
Treatment of antibody-mediated disease
10.15-11.15
Therapeutic options for desensitization before grafting and antibodiesmediated rejection, a review of the (scarce) evidence: Intravenous
immunoglobulin, plasma removal, Bortezomib, and many others…
Denis GLOTZ (Paris, France)/ Robert MONTGOMERY (Baltimore,
USA)
11.30-11.45 Coffee break
11.45-12.05
Therapeutic cleavage of antibodies by endopeptidase IdeS
Gunnar TUFEVSON (Uppsala, Sweden)
12.05-12.25
A place for antibody that enhances IgG degradation (Abdeg)?
Sally WARD (Dallas, USA)
12.30-13.30 LUNCH
13.30-14.00
Blockade of the complement pathways
Christophe LEGENDRE (Paris, France)
14.15-14.45
The future of B cell targeted therapy: inhibit effector B cells while
enhancing regulatory B cells.
Menna CLATWORTHY (Cambridge, UK)
15.00-15.30 Synthesis and Prospects
Olivier THAUNAT (Lyon, France) - Kathryn WOOD (Oxford, UK)