Chapter 2: Mendel’s Principles of Heredity.
When available, the links under the Suggested Readings section will take you to websites
that either provide free electronic full-text versions of these references, or links to online
abstracts. All of these abstracts are themselves free. Many of the abstract sites contain
links to online full-text versions of the references; some of these full-text versions are
free, while others require personal or institutional subscriptions. None of the sites that can
be accessed through the links below are affiliated with McGraw-Hill Publishers.
Mendel and the Early History of Genetics:
Suggested Readings:
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Correns, C. 1950. G. Mendel’s law concerning the behavior of progeny of varietal
hybrids. Genetics 35 (5, part II): 33-41. [link to full-text version]
Carl Correns was one of the three scientists who rediscovered Mendel’s work in
1900. This is the English version of the manuscript.
De Vries, H. 1950. Concerning the law of segregation of hybrids. Genetics 35 (5,
part II): 30-32. [full-text link]
Hugo De Vries was one of the three scientists who rediscovered Mendel’s work in
1900. This is the English version of the manuscript
Tschermak, E. 1950. Concerning artificial crossing in Pisum sativum. Genetics 35
(5, part II): 42-47. [full text link]
Erik von Tschermak was one of the three scientists who rediscovered Mendel’s
work in 1900. This is the English version of the manuscript
Carlson, Elof. A. 2004. Mendel’s Legacy: The Origin of Classical Genetics. Cold
Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
This book presents the complete history of early Mendelian genetics. It focuses on
the work immediately before and after Gregor Mendel. The illustrations and
photographs are excellent.
Websites:
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The Biology Project at the University of Arizona.
http://www.biology.arizona.edu/mendelian_genetics/mendelian_genetics.html
This site contains several examples of monohybrid and dihybrid crosses. A
particularly useful feature of this site is a series of multiple choice quizzes to test
your knowledge of Mendelian genetics. Tutorial links are also provided to help
you identify misunderstandings that can lead to incorrect answers.
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MendelWeb: Gregor Mendel’s manuscript. “Experiments in Plant Hybridization”
http://www.mendelweb.org/Mendel.html
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This is an English version of Gregor Mendel’s manuscript. The manuscript
contains useful hyperlinks to a glossary to assist with terminology.
The MendelWeb project contains additional reference materials describing
Mendel’s life and his contributions to genetics. A complete table of contents for
MendelWeb can be accessed at:
http://www.mendelweb.org/MWtoc.html
The Practice of Human Genetics
Selected Readings

Griesenbach, U, DM Geddes and EWFW Alton. 2004. Gene Therapy for Cystic
Fibrosis: An Example for Lung Gene Therapy. Gene Therapy 11: S43-S50
[Entrez – PubMed abstract]
This paper provides a review of the major gene therapy delivery mechanisms
currently under investigation, including both viral and non-viral systems.

Melone, Mariarosa, Jori Francesco and Gianfranco Peluso. 2005. Huntington’s
Disease: New Frontiers for Molecular and Cell Therapy. Current Drug Targets 6:
43-56.[Entrez-PubMed abstract]
This paper begins with an overview of Huntington disease and the effects of the
trinucleotide repeat that is responsible for the disease. The paper contains an
excellent section on stem cell therapies; this material will help you understand
how stem cells are used in research and the treatment of human disease.
Websites
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The Cystic Fibrosis Foundation (CFF):
http://www.cff.org/
The About Cystic Fibrosis & ’65 Roses’ link at the top left of the page will bring
you to an overview of the phenotypes associated with cystic fibrosis, current
knowledge about the genetics of this disease, and treatments being used to
ameliorate its effects. The Research & Clinical Trials link will bring you to
information on cutting edge research into the genetics and treatment of cystic
fibrosis.
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Huntington Disease Genetics:
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http://ghr.nlm.nih.gov/condition=huntingtondisease
This site, hosted by the National Library of Medicine, provides a jumping off
point to a wealth of information on Huntington disease. Included is a glossary of
key terms and links to sites about the study of human genetics.
Online Database of Human Genetic Diseases (OMIM)
Websites

Online Mendelian Inheritance in Man (OMIM)
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM
This is the ultimate reference site for anyone who wishes to gather more information
on a specific gene. Within the site are maps of human chromosomes; links to relevant
papers associated with any given gene; and external links to a number of useful
resources, including genome guides for most of the major model organisms.
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