Chapter 2: Mendel’s Principles of Heredity. When available, the links under the Suggested Readings section will take you to websites that either provide free electronic full-text versions of these references, or links to online abstracts. All of these abstracts are themselves free. Many of the abstract sites contain links to online full-text versions of the references; some of these full-text versions are free, while others require personal or institutional subscriptions. None of the sites that can be accessed through the links below are affiliated with McGraw-Hill Publishers. Mendel and the Early History of Genetics: Suggested Readings: Correns, C. 1950. G. Mendel’s law concerning the behavior of progeny of varietal hybrids. Genetics 35 (5, part II): 33-41. [link to full-text version] Carl Correns was one of the three scientists who rediscovered Mendel’s work in 1900. This is the English version of the manuscript. De Vries, H. 1950. Concerning the law of segregation of hybrids. Genetics 35 (5, part II): 30-32. [full-text link] Hugo De Vries was one of the three scientists who rediscovered Mendel’s work in 1900. This is the English version of the manuscript Tschermak, E. 1950. Concerning artificial crossing in Pisum sativum. Genetics 35 (5, part II): 42-47. [full text link] Erik von Tschermak was one of the three scientists who rediscovered Mendel’s work in 1900. This is the English version of the manuscript Carlson, Elof. A. 2004. Mendel’s Legacy: The Origin of Classical Genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. This book presents the complete history of early Mendelian genetics. It focuses on the work immediately before and after Gregor Mendel. The illustrations and photographs are excellent. Websites: The Biology Project at the University of Arizona. http://www.biology.arizona.edu/mendelian_genetics/mendelian_genetics.html This site contains several examples of monohybrid and dihybrid crosses. A particularly useful feature of this site is a series of multiple choice quizzes to test your knowledge of Mendelian genetics. Tutorial links are also provided to help you identify misunderstandings that can lead to incorrect answers. MendelWeb: Gregor Mendel’s manuscript. “Experiments in Plant Hybridization” http://www.mendelweb.org/Mendel.html Chapter 2 1 This is an English version of Gregor Mendel’s manuscript. The manuscript contains useful hyperlinks to a glossary to assist with terminology. The MendelWeb project contains additional reference materials describing Mendel’s life and his contributions to genetics. A complete table of contents for MendelWeb can be accessed at: http://www.mendelweb.org/MWtoc.html The Practice of Human Genetics Selected Readings Griesenbach, U, DM Geddes and EWFW Alton. 2004. Gene Therapy for Cystic Fibrosis: An Example for Lung Gene Therapy. Gene Therapy 11: S43-S50 [Entrez – PubMed abstract] This paper provides a review of the major gene therapy delivery mechanisms currently under investigation, including both viral and non-viral systems. Melone, Mariarosa, Jori Francesco and Gianfranco Peluso. 2005. Huntington’s Disease: New Frontiers for Molecular and Cell Therapy. Current Drug Targets 6: 43-56.[Entrez-PubMed abstract] This paper begins with an overview of Huntington disease and the effects of the trinucleotide repeat that is responsible for the disease. The paper contains an excellent section on stem cell therapies; this material will help you understand how stem cells are used in research and the treatment of human disease. Websites The Cystic Fibrosis Foundation (CFF): http://www.cff.org/ The About Cystic Fibrosis & ’65 Roses’ link at the top left of the page will bring you to an overview of the phenotypes associated with cystic fibrosis, current knowledge about the genetics of this disease, and treatments being used to ameliorate its effects. The Research & Clinical Trials link will bring you to information on cutting edge research into the genetics and treatment of cystic fibrosis. Huntington Disease Genetics: Chapter 2 2 http://ghr.nlm.nih.gov/condition=huntingtondisease This site, hosted by the National Library of Medicine, provides a jumping off point to a wealth of information on Huntington disease. Included is a glossary of key terms and links to sites about the study of human genetics. Online Database of Human Genetic Diseases (OMIM) Websites Online Mendelian Inheritance in Man (OMIM) http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM This is the ultimate reference site for anyone who wishes to gather more information on a specific gene. Within the site are maps of human chromosomes; links to relevant papers associated with any given gene; and external links to a number of useful resources, including genome guides for most of the major model organisms. Chapter 2 3