2004 KOSEF-JSPS Asian Science Seminar Development of Mucosal Vaccines From Basic Research to Clinical Application INTERNATIONAL VACCINE INSTITUTE (IVI), Seoul, Korea October 24-27th, 2004 AGENDA Sunday, 24th October, 2004 16.00 – 18.00 Registration (Novotel Hotel) 18.00 – 20.00 Welcome to participants (Novotel Hotel) Monday, 25th October, 2004 09.00 – 09.30 Opening remarks Tadashi Yamamoto (University of Tokyo, Japan) John D. Clemens (IVI, Korea) Officers from KOSEF and JSPS SESSION I Basic Aspect of Mucosal Immune System Chairperson : Aldo Tagliabue (IVI, Korea) Tadashi Yamamoto (University of Tokyo, Japan) 09.30 – 10.00 Infectious diseases and their control: Past, present and future Yoshifumi Takeda (Jissen Women’s University, Japan) 10.00 – 11.00 Uniqueness of mucosal immune system Hiroshi Kiyono (University of Tokyo, Japan) 11.00 – 12.00 Role of costimulation in immunity Byoung S. Kwon (University of Ulsan, Korea) 12.00 – 13.00 Lunch SESSION II Organogenesis of Mucosal Lymphoid Tissues Chairperson : Byoung S. Kwon (University of Ulsan, Korea) 13.00 – 14.00 Lymphoid organogenesis Martin Lipp (Max-Delbrück-Centre for Molecular Medicine, Germany) 14.00 – 15.00 Peyer’s patch organogenesis Hisahiro Yoshida (RIKEN, Japan) 15.00 – 15.30 Coffee break 15.30 – 16.30 Antigen sampling and uptake in the mucosal tissues Florence Niedergang (Institute Curie, France) 16.30 – 17.30 Functional development of intestinal immune surveillance Hiromichi Ishikawa (Keio University, Japan) 17.30 – 18.00 Tour of IVI (guide by Dr. Aldo Tagliabue) 18.00 – 20.00 Dinner - Korean Barbecue (IVI lobby) Tuesday, 26th October, 2004 SESSION III Regulation of Mucosal Lymphocyte Homing Chairperson : Masafumi Yamamoto (Nihon University, Japan) 09.00 – 10.00 Lymphocyte trafficking across high endothelial venules: dogmas and enigmas Masayuki Miyasaka (Osaka University, Japan) SESSION IV Innate and Acquired Immunity in Mucosal Tissues Chairperson : Masayuki Miyasaka (Osaka University, Japan) 10.00 – 11.00 TLRs for the mucosal immunity Kiyoshi Takeda (Kyushu University, Japan) 11.00 – 12.00 Role of GALT for mucosal IgA immunity Masafumi Yamamoto (Nihon University, Japan) 12.00 – 13.30 Lunch & preparation for poster presentation SESSION V Molecular and Cellular Aspect of Mucosal Infectious Diseases Chairperson : Yoshifumi Takeda (Jissen Women’s University, Japan) 13.30 – 14.30 Molecular mechanism of Shigella infection Chihiro Sasakawa (University of Tokyo, Japan) 14.30 – 15.30 Mucosal invasion by Salmonella Ho Young Kang (Pusan National University, Korea) 15.30 – 16.00 Coffee break 16.00 – 17.00 Molecular aspects of influenza virus: exploiting genome packaging to develop vaccines by reverse genetics Taisuke Horimoto (University of Tokyo, Japan) 17.00 – 18.00 Perspectives of AIDS vaccine development Young Chul Sung (Pohang University of Science & Technology, Korea) 18.00 – 20.00 Poster Presentation (IVI lobby) 2 Wednesday, 27th October, 2004 SESSION VI New Trends in Mucosal Vaccine Development Chairperson : Hiroshi Kiyono (University of Tokyo, Japan) 08.30 – 09.30 New TB vaccine strategies by the use of CD1 immunity Masahiko Sugita (Kyoto University, Japan) 09.30 – 10.30 TB derived peptide 25 as a new immunomodulator Kiyoshi Takatsu (University of Tokyo, Japan) 10.30 – 10.45 Coffee break 10.45 – 11.30 Bacterial enterotoxins as mucosal adjuvants Mi-Na Kweon (IVI, Korea) 11.30 – 12.30 TLR-targeted mucosal adjuvant Joon-Haeng Rhee (Chonnam National University, Korea) 12.30 – 13.30 Lunch SESSION VII From Laboratory Research to Field Trials Chairperson : John D. Clemens (IVI, Korea) 13.30 – 14.00 From bench to bedside John D. Clemens (IVI, Korea) 14.00 – 14.30 Field studies of the oral Cholera vaccine Jacqueline Deen (IVI, Korea) 14.30 – 15.00 Role of field studies in developing Shigella vaccines Lorenz von Seidlein (IVI, Korea) 15.00 – 15.30 Clinical trial of oral vaccine for Salmonella typhi Aldo Tagliabue (IVI, Korea) 15.30 – 16.00 Coffee break 16.00 – 17.30 Round Table or Panel Discussion “How can we bridge between the basic science in mucosal immunology and translational research for field trials” Chairperson : John D. Clemens (IVI, Korea) Hiroshi Kiyono (University of Tokyo, Japan) 17.30 – 18.00 Summary and Conclusion 3