Curriculum Vitae of Dr. Gerjo JVM van Osch
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Male/female:
Date&place of birth:
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Master's University:
Dr. GJVM (Gerjo) van Osch
female
22 june 1967, Maasdriel
NL
Utrecht University, Medical Biology, 19 february 1990
Doctorate University:
Title of thesis:
Nijmegen University; 19 september 1994
Site-specific changes in experimental degenerative knee joint disease
in mice. Biochemical, histological and biomechanical analysis.
Promotores: Prof dr WB van den Berg & Prof dr ir R Huiskes
Work experience
February 2007- present:
Associate professor at Erasmus MC Rotterdam
November 2005- February 2007:Assistent professor at Erasmus MC Rotterdam
August 2000 - November 2005: Sientific researcher at Erasmus MC Rotterdam
March 1995 - August 2000:
Postdoc at Erasmus University Rotterdam (fixed-term)
February 1994-February 1995: Postdoc, University Nijmegen (fixed-term).
February 1990-February 1994: PhD student, University Nijmegen
Description of the group’s reserach relating to regenerative medicine
The central research question of the group is: “what drives cells in degenerating and
regenerating connective tissues?” The focus lies on anabolic processes in tissue repair. Tissue
repair processes play a role in pathophysiology as well as in therapy. In degenerative diseases
of connective tissues of the musculoskeletal system, like osteoarthritis and tendinosis, repair
processes occur as response to wounds, overloading or inflammation. If the repair is not
appropriate, the extra-cellular matrix formed is of inferior quality contributing to a
progressive degeneration of the tissues.
To repair lesions in connective tissues we aim to use autologous cells in tissue engineering
and cell therapeutic procedures. Different factors are used in order to direct cells to
differentiate towards a certain phenotype or to generate the desired matrix. For our studies we
use a variety of different donor cell sources (e.g. articular, auricular and nasal chondrocytes,
bone marrow derived stromal cells and adipose derived cells).
We perform translational research from a cell biological view point in a group consisting
of people with different backgrounds.
Supervised >40 undergraduate and graduate students
Grants (>50 kEuro) as (co-)PI
- Novel cell sources for cartilage tissue engineering BTS 00021 (Senter, Dutch Ministry of
Economic Affairs) july2000 – june2004; 400 kEuro
- A novel approach to stimulate cartilage repair: targeting collagen turnover. NR 02-2-401
(Dutch Arthritis Association) oct. 2003 – dec2008; 354 kEuro (CO-PI with J de Groot)
- Cartilage Tissue engineering Bsik3 programme: “Dutch Platform for Tissue engineering”
(Dutch Ministry of Education and Sciences) jan2005 – dec2009; 543 kEuro
- Towards ex-vivo siRNA therapeutic approach of osteoarthritic cartilage. (Dutch Arthritis
Association) Oct 2005-Mrt 2007; 75kEuro
- Targetting cells in combination with surgical interventions to stimulate cartilage repair in
osteoarthritis. (Dutch Arthritis Association; long term research programme). 2006-2013; 800
kEuro (Co-PI with J Verhaar)
- Osteoarthritis: models, mechanisms and markers for patient stratification. (Top Institute
Pharma; Ministry). 2007–2011; total budget 3.800 kEuro, 400KEuro for Erasmus MC (Co-PI
with J de Groot and G Kloppenburg)
- Translational Regenerative Medicine: Cartilage regeneration: intervening to change the
continuum. (part of SmartMix proposal, Ministry of Education, Culture and Science and
Ministry of Economic Affairs). 2007–2012; 1080 kEuro (Co-PI with H Weinans)
- Dutch Arthritis Association; Does local fat contribute to joint fibrosis? 2009-2010;
78.5kEuro (PI)
- Marie Curie grant: Development of a model of in vitro endochondral ossification with
neovascularisation. 2008-2009; 119 kEuro (coordinator)
Currently approx. 80 publications in peer reviewed journals.
5 selected publications of the last 5 years
- de Mos M, Koevoet W, van Schie HT, Kops N, Jahr H, Verhaar JA, van Osch GJ. In Vitro
Model to Study Chondrogenic Differentiation in Tendinopathy. Am J Sports Med. 2009 Mar
11. [Epub ahead of print]
- Farrell E, van der Jagt OP, Koevoet W, Kops N, van Manen CJ, Hellingman CA, Jahr H, O'Brien FJ,
Verhaar JA, Weinans H, van Osch GJ. Chondrogenic Priming of Human Bone Marrow Stromal Cells:
A Better Route to Bone Repair? Tissue Eng Part A. 2008 Dec 24. [Epub ahead of print]
- Jenniskens YM, Koevoet W, de Bart AC, Weinans H, Jahr H, Verhaar JA, DeGroot J, van Osch
GJ.Biochemical and functional modulation of the cartilage collagen network by IGF1, TGFbeta2 and
FGF2.Osteoarthritis Cartilage. 2006 Nov;14(11):1136-46.
- Uitterlinden EJ, Jahr H, Koevoet JL, Jenniskens YM, Bierma-Zeinstra SM, Degroot J, Verhaar JA,
Weinans H, van Osch GJ.Glucosamine decreases expression of anabolic and catabolic genes in human
osteoarthritic cartilage explants.Osteoarthritis Cartilage. 2006 Mar;14(3):250-7
- Mandl EW, van der Veen SW, Verhaar JA, van Osch GJ. Serum-free medium supplemented with
high-concentration FGF2 for cell expansion culture of human ear chondrocytes promotes
redifferentiation capacity. Tissue Eng. 2002 Aug;8(4):573-80
Boards and committees (selection):
• Editorial Boards of Journal Tissue Engineering and J Tissue Engineering and Regenerative
Medicine.
• Vice chair steering board European Science Foundation network REMEDIC (2008-2013)
• Member reference group of a European Science Foundation Policy Briefing on "Stem Cells
and Regenerative Medicine" (2008-2009).
• Member several committee of the International Cartilage Repair Society (2004-present)
• Scientific Advisory committee Dutch Arthritis Association (2006-2008)
• Board member European Council of the Tissue Engineering and Regenerative Medicine
International Society (2005-present)
• Member Program committee Bsik3 “tissue engineering” (2004-2010)
• Co-founder/ secretary Netherlands Society Matrix Biology (2000-2005)
• Congres chair Annual European meeting Tissue Engineering & Regenerative Medicine
International Society, Rotterdam, 2006
- Organiser ICRS Laboratory Skills Course in 2008