CHING-CHUAN, JIANG (江清泉)
by sharon, 2011-01-26 15:14, 人氣(228)
PROFESSOR
TISSUE ENGINEERING CARTILAGE RESEARCH
“Once destroyed, it never repaired.” This statement
about articular cartilage lesions remained true until
1994 when the Swedish researchers published their
works of autologous chondrocyte implantation in the
New England Journal of Medicine. The chondrocycles
can be harvested, cultured in the laboratory for about
3 weeks and implanted into the chondral defect site.
Hyaline cartilage was found in the repaired tissue.
However, the complicated laboratory procedures made
the clinical application far from easy.
In collaboration with the researchers from the
Industrial Technology Research Institute, we have
developed the biphasic matrix to host the chondrocytes
that were obtained from enzymatic digestion of the
chopped articular cartilage harvested from the nonweight
bearing site of the joint. From series of per-clinical animal
experiments, the osteochondral defects could be
repaired. This new technology has several advantages:
1.No need for laboratory manuals to acquire
chondrocytes. 2. The procedure could be done through
arthroscopic procedure in one stage operation in about
30 minutes. 3. The procedure is easy to learn.
This technology was transferred to the Exactech in
March 2008. A Multi-center clinical trial is ongoing
in Taiwan. We anticipate to obtain the license to
market the biphasic matrix in Taiwan in the coming years.
• Jiang CC, Chiang H, Liao CJ , Lin YJ , Kuo TF, Shieh CS, Huang YY,
Tuan TS. Repair of porcine articular cartilage defect with a biphasic
osteochondral composite. J Orthop Res. 2007; 25(10):1277-90.
• Chiang H, Liao CJ, Wang YH, Huang HY, Chen CN, Hsieh CH, Huang
YY, Jiang CC. Comparison of articular cartilage repair by autologous
chondrocytes with and without in vitro cultivation. Tissue Eng Part C
Methods. 2010;16(2):291-300.