CARDIOVASCULAR SCIENCES COLLABORATIVE PROGRAM
UNIVERSITY OF TORONTO
ANNUAL ACTIVITY REPORT 1993/1994
The Cardiovascular Sciences Collaborative Program has completed its second academic year. The continuing goal
of this exciting program is to develop co-operative and joint graduate teaching and research across departmental
boundaries, within the Faculty of Medicine. With the support of The Centre for Cardiovascular Research, the
Program builds on the strengths of the collaborating graduate departments, enhancing the visibility of cardiovascular
studies and facilitating interdisciplinary training and research. The Program offers diverse areas of training
including 2 major streams of study: Cardiac and Vascular.
The Program is located in the FitzGerald Building. As well, a satellite office was opened at The Toronto Hospital.
The Program's Director is Dr. Carin Wittnich with Victoria Simpson, Administrative Assistant, handling the day-today functions.
COLLABORATING DEPARTMENTS
The Centre for Cardiovascular Research and the Department of Clinical Biochemistry joined the Program.
Clinical:
Department of Medicine
Department of Surgery
Graduate:
Cellular and Molecular Pathology
Department of Clinical Biochemistry
Department of Community Health (Exercise Science Program)
Department of Pharmacology
Department of Physiology
Institute of Medical Science (IMS)
Other:
The Centre for Cardiovascular Research
EXECUTIVE COMMITTEE
The Executive Committee consists of a representative from each collaborating department.
Dr. C. Wittnich (Director)
Dr. M. Plyley (Community Health)
Dr. A.I. Gotlieb (Pathology)
Dr. C. Forster (Pharmacology)
Dr. D.H. Osmond (Physiology)
Dr. R.D. Weisel (IMS)
Professor C-C. Liew (Clinical Biochemistry)
COURSES OFFERED
CHL4607H
Cardiovascular Adaptations to Exercise and Environment (Community Health)
CHL3608H
Ischemic Heart Disease and Physical Activity (Community Health)
CLB1407
From Bench to Bedside: Design, Measurement and Analysis for Clinical Investigators (Clinical
Biochemistry)
CLB1504
Biochemistry, Molecular Biology of Cardiovascular Disease (Clinical Biochemistry)
CLB1503
Signal Transduction Pathways in Normal and Diseased Tissue (Clinical Biochemistry)
MSC3060H*
Advanced Research in Cardiovascular Sciences I (IMS)
MSC3061H*
Advanced Research in Cardiovascular Sciences II (IMS)
PAT1015H
PCL1006Y
PSL1029H
PSL1060H
PSL1038H
Vascular Pathobiology (Pathology)
Cardiovascular Pharmacology (Pharmacology)
Advanced Course in Cardiovascular Regulation (Physiology)
Developmental Cardiovascular Physiology (Physiology)
Volume, Electrolyte and Pressure Regulation in Body Fluid Compartments (Physiology)
*Core Courses
For a Doctoral Degree, the student is required to take the full credit course MSC 3060/3061 as well as fulfil the
requirements of the home department.
For a Master's Degree, the student is required to take a one-half credit course selected from the cardiovascular
curriculum in addition to any specific requirements from the home department.
PROGRAM SPONSORED ACTIVITIES
Annual Cardiovascular Scientific Day - June 16, 1994
The Annual Scientific Day is organized to bring together faculty from across the University of Toronto. It is run
jointly with the CCR Retreat. The aim is to provide an update in the frontiers of cardiovascular science and each
symposium focuses on either clinical or basic science research. All attendees are encouraged to actively participate
to promote cross-fertilization of ideas and research direction.
This year's workshop was held at the Inn on the Park where there were over 230 registrants. The meeting featured
Dr. Murray Esler, Professor of Medicine, Monash University, Baker Medical Research Institute, Melbourne,
Australia, as the keynote speaker who spoke on Clinical Testing of Sympathetic Nervous System Function: Out of
the Dark Ages. The central symposium revolved around Women and Cardiovascular Disease. Simultaneous
sessions included Ischemia-Reperfusion, Molecular Mechanisms in Heart Failure, Challenges and Insights of
Clinical Trials, Myocardial Function and Survival as well as topics in Nursing and Perfusion.
22 abstracts were submitted for the poster session. This session allows students to present their research work to a
broader based group. Again this year, Mosby generously supplied textbooks as awards for the top 3 posters. The
poster session winners were Jun Su, Cathy Carlyle, and Roberto Diaz.
Dr. Nadine Clausell was presented with a certificate from the Program. She completed her PhD under the
supervision of Dr. M. Rabinovitch and was the first student to complete the Program. Nadine's thesis was entitled
"Increased fibronectin regulated by cytokines is associated with development of a coronary arteriopathy post cardiac
transplantation".
A complimentary lunch facilitated faculty/student exchange and the meeting was evaluated at 6 CME credits. With
industry and The Centre for Cardiovascular Research support, registration fees were again waived to allow all
interested to attend.
This year's Scientific Day attracted the largest registration ever from across the healthcare disciplines. Response to
questions circulated to attendees indicated a high degree of satisfaction with the location, scientific content, and
speakers; many of whom were program faculty. The central symposium addressed a timely gender issue (Women &
Heart Disease) and included presentations on career development in the field of cardiovascular, as well as healthcare
issues relating to women and the development of cardiovascular disease such as symptoms and diagnosis; risk of
pregnancy, gender related outcomes of cardiac surgery and abdominal aortic aneurysm surgery. Attendees also
heard firsthand about the new Heart and Stroke Foundation of Ontario initiatives in this area.
This meeting has become the highlight of our academic year!
Heartline
Heartline is the Program's newsletter which runs 8-12 pages in length. It contains various sections entitled
University Update, Hospital Update, Industry Update (where the latest in information of interest to the
cardiovascular community is presented), feature articles on current state-of-the-art research in clinical interventions,
historical vignettes, news from the collaborating departments, meeting dates, grant and abstract deadlines, and a
listing of the program faculty.
Due to budgetary constraints, 2 issues were produced this year. Attempts will be taken to raise funding to produce 4
issues per year, which would be facilitated if one major sponsor could be found. One industry sponsor had
commited for the year but, due to restructuring within the company, was forced to withdraw at the last minute.
Currently, funding is raised on a per issue basis.
Inside the Heart Lecture Series
This lecture series covers current state-of-the-art research topics throughout the year and is presented by Program
faculty. These seminars are advertised in the Faculty of Medicine's Research Events as well as being mailed to all
faculty and students and notices posted around campus.
Industry Sponsored Seminars
In addition to the weekly Cardiovascular Seminars, industry is invited to sponsor a seminar. A feature topic is
discussed where national and international guest speakers are invited.
On February 4 1994, Dr. Ron Smith, Associate Director, Cardiovascular Sciences, Dupont Merck, USA, spoke on
the "Pathophysiological Role of Angiotensin II in Cardiac Tissue".
ADVERTISING MATERIAL
The Program has created a poster that has been circulated across campus. Other material that gives the Program
exposure is the Program brochure, Annual Scientific Day pamphlet, and Industry sponsored seminars.
PROGRAM FACULTY
The faculty are divided into 3 categories (Full, Associate, and Affiliate) depending on their SGS status. Affiliate
members participate in graduate training but do not, as yet, have SGS status.
FULL:
ASSOCIATE:
AFFILIATE:
U. Ackermann, C.E. Bayliss, D. Bradley, J. Edelson, J.S. Floras, C. Forster, A.I.
Gotlieb, K.W. Johnston, P.G. Kalman, B.L. Langille, C.C. Liew, P. Liu, P. McLaughlin,
D.A.G. Mickle, L. Mickleborough, R.I. Ogilvie, D.H. Osmond, M.J. Plyley, M.
Rabinovitch, I. Rebeyka, N.A. Shaikh, R.J. Shephard, I. Sherman, M.D. Silver, K.
Skorecki, A.S. Slutsky, M.J. Sole, H. Sonnenberg, G. Steiner, P. Walker, R.D. Weisel, G.
Wilson, C. Wittnich, T-W. Wu,
J. Coles, E. Conway, J.M. Goodman, LS. Goodman, J. Irvine, S.G. Thomas
A.G. Adelman, R.J. Burns, J. Butany, C.M. Feindel, G.F. Lewis, T. Lindsay, L.
Schwartz, E.L. Yeo.
Dr. P.A. Armstrong resigned from the Program due to a new career commitment and Drs. Hanly and Salerno did not
renew their membership.
PROGRAM STUDENTS
Student
Supervisor
Degree
Department
Ms. Cathy Carlyle
Dr. Bryce Cowan
Dr. Ricardo Fontani
Dr. John Ikonomidis*
Ms. Giulia Larosa
Dr. Silvana Molossi
Ms. Shona Torrance
Dr. Sonia Yovtcheva
Dr. C. Wittnich
Dr. M. Rabinovitch
PhD
Dr. G. Steiner
Dr. R. Weisel
Dr. C. Forster
Dr. M. Rabinovitch
Dr. C. Wittnich
Dr. D. Osmond
MSc
IMS
Pathology
MSc
PhD
PhD
PhD
PhD
MSc
IMS
IMS
Pharmacology
Pathology
IMS
Physiology
* Dr. John Ikonomidis first joined the Program as a MSc student under the supervision of Dr. Weisel. After 1.5
years, he successfully transferred into the PhD program.
CONVOCATED STUDENTS/FOLLOW-UP
Dr. Nadine Clausell (Supervisor: Dr. M. Rabinovitch) obtained her PhD degree through the Department of
Pathology in 1993. Nadine is currently working at The Toronto Hospital. She obtained a Heart and Stroke
Foundation of Canada Postdoctoral Fellowship in July 1993 on Cardiac Transplantation and will be continuing with
this research until December 1994. At that time she will be returning to Brazil where she will become a member of
the Division of Cardiology at the Hospital de Clinicas, Porto Alegre, Brazil.
STUDENT ACHIEVEMENTS
Dr. Bryce Cowan
Dr. Riccardo Fontani
Dr. John Ikonomidis
Ms. Giulia Larosa
Dr. Silvana Molossi
Ms. Shona Torrance
Dr. Sonia Yovtcheva
SANDOZ Pharmaceuticals Research Scholarship
Summer Studentship, Juvenile Diabetes Foundation
Internal Medicine Scholarship, University of Sienna
Medical Research Council Research Fellowship
Davis & Geck Award
Ontario Graduate Scholarship
Doctoral Fellowship, Univ of Toronto
Scholarship for Doctoral Training, Brazilian Government
Clinician Scientist Award, The Lunenfeld
Foundation, Hospital for Sick Children
Research Traineeship, Heart & Stroke Foundation of Canada
Richard Rowe Research Prize, Canadian Pediatric
Cardiology
Association, Canadian Cardiovascular Society
Life Sciences Summer Student Award, Univ of Toronto
John Hepburn Award, Medical Alumni Assoc., Univ of Toronto
DIRECTOR'S COMMENTS
This past year was, again, very busy for the Program. We now have 3 Master's and 5 PhD trainees; which is an 80%
increase from the 1991-1993 academic year (The excellence of each of our trainees is reflected in the student
achievements section.); total faculty increased from 44 to 49; the Department of Clinical Biochemistry was
recruited; and the number of graduate courses available to our students went from 9 to 12.
In collaboration with The Centre for Cardiovascular Research, we had our most successful Scientific Day with over
230 attendees and 6 CME credits issued.
The Program's profile is beginning to be recognized across campus. This was reflected in the Director being asked
by Professor J. Hellebust, Associate Dean, Division IV, to participate in the Neurosciences Program review. Also,
on the recommendation of the Provost, Dr. Wittnich met with Dr. John Frank, Provostial Advisor on Population
Health to lend advice on starting a collaborative program at the University.
The goals for the past year, which included establishing semi-permanent administrative offices, recruiting
appropriate faculty and students, organizing and hosting the Annual Workshop, and publishing the newsletter
"Heartline", were all successfully met. The opening of a satellite office at The Toronto Hospital permitted the
Program to share its office staff. The Program Executive worked hard and dealt with numerous issues including
creation of a certificate of completion issued to convocating students, student recruitment, implementation of an
annual student assessment form, and renewal of faculty membership levels -- to name a few. We also welcomed
another participating department (Clinical Biochemistry).
A student room was created for use by Program students and faculty. This room has desks, a reading area and will
have journals and cardiovascular textbooks available in the near future. A bulletin board is also available for
exchange of information.
An external funding campaign was mounted. It was directed mostly at industry through the contacts of the Director
but also privately with the help of Mr. Doug Gortner, Director of Development and Alumni Affairs, School of
Graduate Studies. Some interest from industry was illicited.
The Director also initiated an annual meeting with each Program student to discuss their progress, suggestions for
Program improvements, and to identify any potential areas of concern. This will occur on an annual basis
(June/July).
Student recruitment was expanded by display booths at the Faculty of Medicine, Student Scientific Day and the
UofT Day. Brochures and posters were exhibited and the Director, Administrative Assistant, and a Program student
were available to answer questions.
For next year, we plan to continue these activities and below are the plans and priorities for 1994-95:
1.
2.
3.
4.
5.
6.
Encourage more faculty to enroll their best students in the Program - especially in departments less active
at the moment.
Promotion of cardiovascular sciences as a specialty area of graduate training: expand circulation of posters
to interest more students, both at the University and outside academic, teaching and research institutions.
Student funding (travel awards, studentships, etc.).
Establish permanent base financial support.
Facilitate the recruitment of interested faculty to participate in graduate training and support our affiliate
members to move to status appointments with the School of Graduate Studies.
Continue to improve upon existing Program activities.
PUBLICATIONS - STUDENTS
Clausell N, Molossi S, Rabinovitch M: Increased interleukin-1 and fibronectin synthesis are early features of the
development of the post-cardiac transplant coronary arteriopathy in piglets. Am J Pathol 142, 1772-1786, 1993.
Ikonomidis JS, Weisel RD, Mickle DAG: Ischemic preconditioning: Cardioprotection for cardiac surgery. J Card
Surg 9(Suppl):526-531, 1994.
Ikonomidis JS, Yau TM, Weisel RD, Mickle DAG, Hayashida N, Ivanov J, Carson S, Mohabeer M, Tumiati LC:
Optimal flow rates for retrograde warm cardioplegia. J Thorac Cardiovasc Surg 107:510-519, 1994.
Larosa G, Armstrong PW, Seeman P, Forster C: -Adrenoceptor recovery after heart failure in the dog. Cardiovasc
Res 27:489-493, 1993.
Forster C, Naik GOA, Larosa G: Myocardial -adrenoceptors in pacing-induced heart failure: Regulation by
enalapril? Can J Physiol Pharmacol 72:667-672, 1994.
Molossi S, Clausell N, Rabinovitch M: Coronary artery endothelial interleukin-1 mediates enhanced fibronectin
production related to post-cardiac transplant athrosclerosis in piglets. Circulation 88(Part II):248-256, 1993.
Wittnich C, Torrance SM: Does the severity of acute hypoxia influence neonatal myocardial metabolism and
sensitivity to ischemia? J Mol Cell Cardiol 26(5):675-682, 1994.
Yau TM, Ikonomidis JS, Weisel RD, Mickle DAG, Hayashida N, Ivanov J, Carson S, Mohabeer M, Tumiati LC:
Which techniques of cardioplegia prevent ischemia? Ann Thorac Surg 56:1020-1028, 1993.
Yau TM, Ikonomidis JS, Weisel RD, Mickle DAG, Hayashida N, Ivanov J, Carson S, Mohabeer M, Tumiati LC:
Ventricular function after normothermic versus hypothermic cardioplegia. J Thorac Cardiovasc Surg 105:833-844,
1993.
Yoo S-J, Moes CAF, Burrows PE, Molossi S, Freedom RM: Pulmonary blood supply by a branch from the distal
ascending aorta in pulmonary atresia with ventricular septal defect: Differential diagnosis of fifth aortic arch. Ped
Cardiol 14:230-233, 1993.
PUBLICATIONS - FACULTY
Aaron SD, Warner E, Edelson JD: Bronchogenic carcinoma in patients seropositive for human immunodeficiency
virus. Chest 106:640-642, 1994.
Abouchacra S, Baines AD, Zinman B, Skorecki K, Logan A: Insulin blunts the natriuretic action of atrial
natriuretic peptide in hypertension. Hypertension 23:1054-1058, 1994.
Adelman AG, Cohen EA, Kimball BP, Bonan R, Ricci DR, Webb JG, Laremee L, Barbeau G, Traboulsi M, Corbett
BN, Schwartz L, Logan AG: A comparison of directional atherectomy with balloon angioplasty for lesions of the
left anterior descending coronary artery. N Engl J Med 329:228-33, 1993.
Adelman AG, Cohen EA, Kimball BP, Bonan R, Ricci DR, Webb JG, Laramee L, Barbeau G, Traboulsi M, Corbett
BN, Schwartz L, Logan AG: A comparison of directional atherectomy with balloon angioplasty for lesions of the
left anterior descending coronary artery. N Engl J Med 329:228-233, 1993.
Aoyagi Y, McLellan T, Shephard RJ: Effects of training and acclimation on heat tolerance in exercising men
wearing protective clothing. Eur J Appl Physiol 68:234-245, 1994.
Atchison DJ, Ackermann U: The interaction between atrial natriuretic peptide and cardiac parasympathetic
function. J Autonomic Nerv Sys 42:81-88, 1993.
Axford-Gatley RA, Wilson GJ: Myocardial infarct size reduction by single high dose or repeated low dose vitamin
E supplementation in rabbits. Can J Cardiol 9(1):94-98, 1993
Bouchard C, Shephard RJ: Physical activity, fitness and health: The model and key concepts. In: Physical
Activity, Fitness and Health. Bouchard C, Shephard RJ, Stephens T (Eds). Human Kinetics Publishers, Champaign,
Illinois 77-88, 1994.
Bouchard C, Shephard RJ: Physical activity, fitness and health: The model and key concepts. In: Physical
Activity, Fitness and Health: Concensus Statement. Bouchard C, Shephard RJ, Stephens T (Eds). Human Kinetics
Publishers, Champaign, Illinois, 11-23, 1993.
Boyd AJ, Sherman IA, Saibil FG: Intestinal microcirculation and leukocyte behaviour in ischemia-reperfusion
injury. Microvascular Res 47:355-368, 1994.
Bradley TD: Breathing during sleep in cardiac disease. In: Sleep and Breathing. Lung Biology in Health and
Disease. Saunders NA, Sullivan CE (Eds). Marcel Dekker, New York 21:787-821, 1993.
Brenner IKM, Shek PN, Shephard RJ: Infection in athletes. Sports Med 17:86-107, 1994.
Bui LN, Thompson M, McKeown N, Romaschin AD, Kalman PG: Surface modification of the biomedical
polymer Poly(ethylene terephthalate). The Analyst 118:463-474, 1993.
Burns RJ (Ed): Nuclear Cardiology - Advances in Interpretation and Methods. Univ Toronto (CME Symposium
Proceedings) 1993 (Book).
Burns RJ: Prognosis in Stable CAD. In: Advanced Techniques in Myocardial Perfusion Imaging. Univ Alberta
Continuing Med Ed, 1993 (Chapter).
Burns RJ: Myocardial viability. In: Advanced Techniques in Myocardial Perfusion Imaging. Univ Alberta
Continuing Med Ed, 1993 (Chapter).
Caspi J, Coles JG, Benson LN, Herman SL, Diaz RJ, Augustine J, Brezina A, Wilson GJ: The protective effect of
magnesium on acute catecholamine toxicity in the neonate. J Thorac & Cardiovasc Surg 105(3):525-531, 1993.
Caspi J, Coles JG, Benson LN, Herman SL, Augustine J, Tsao P, Brezina A, Kolin A, Wilson GJ: Effects of high
plasma epinephrine and Ca2+ concentrations on newborn myocardial function following ischemia. J Thorac &
Cardiovasc Surg 105(1):59-67, 1993.
Clausell N, Molossi S, Sett S, Rabinovitch M: In vivo blockade of tumor necrosis factor-a in cholesterol-fed rabbits
after cardiac transplant inhibits acute coronary artery neointimal formation. Circulation 89:2768-2779, 1994.
Clausell N, Molossi S, Rabinovitch M: Increased interleukin-1 and fibronectin expression are early features of the
development of the post-cardiac transplant coronary arteriopathy in piglets. Am J Pathol 142:1772-1786, 1993.
Clausell N, Rabinovitch M: Up regulation of fibronectin synthesis by interleukin-1 in coronary artery smooth
muscle cells is associated with the development of the post-cardiac transplant arteriopathy in piglets. J Clin Invest
92:1850-1858, 1993.
Coceani F, Kelsey L, Ackerly C, Gelboin H, Rabinovitch M: Cytochrome P450 during ontogenic development:
occurrence in the ductus arteriosus and other tissues. Can J Physiol Pharmacol 72:217-226, 1994.
Cohen EA, Lesperance J, Sykora K, Bourassa MG, Schwartz L: A distinction between process and outcome of
lumen renarrowing after coronary angioplasty. Am J Card 73:962-964, 1994.
Colangelo S, Langille BL, Gotlieb AI: Endothelial microfilament distribution in the immediate vicinity of arterial
branch sites. Cell and Tissue Res 1994.
Cole CW, Johnston KW, Taylor DC, Douville Y: Criteria for the accreditation of noninvasive vascular
laboratories. Can J Surg 37:104,110, 1994.
Coles J, Tsao P, Wilson G, Mills G: Tyrosine kinase-dependent lymphocyte signaling during allograft rejection.
Transplantation Proceedings 25(1):877, 1993.
Collins-Nakai R, Crelinsten G, Earle C, McLaughlin PR: Ethical issues for cardiovascular physicians. Can J
Cardiol 9:391-397, 1993.
Collins-Nakai RL, Rabinovitch M: Pulmonary Vascular Obstructive Disease. In: Congenital Heart Disease in
Adolescents and Adults. Cardiology Clinics, W.B. Saunders, 11(4):675-687, 1993.
Compeau CG, Rotstein OD, Tohda H, Marunaka Y, Rafh B, Slutsky AS, O'Brodovitch H: Endotoxin-stimulated
alveolar macrophages impair lung epithelial Na+ transport by an L-Arg-dependent mechanism. Am J Physiol
266:C1330-C1341, 1994.
Cowan DB, Weisel RD, Williams WG, Mickle DAG: Identification of oxygen responsive elements (OREs) in the
5'-flanking region of the human glutathione peroxidase gene. J Biolog Chem 268(36): 26904-26910, 1993.
Culliname C, Clarke J, Rabinovitch M, Bohn D, Silver M: Hyperplasia of pulmonary arterial media in infantile
familial pulmonary hypertension associated with severe metabolic acidosis. Modern Pathology 6:699-706, 1993.
DeBusk R, Gibbons L, Landry G, Moffatt RJ, Shephard RJ, Smith ML: Writing the exercise prescription. Patient
Management 27(4):104-117, 1993.
DeCampos KN, Waddell TK, Slutsky AS, Wang Y, Wang X, Post M, Patterson GA: Functional and biochemical
assessment of postpreservation lung viability in a rat model. J Appl Physiol 76(2):813-820, 1994.
DeCampos KN, Waddell TK, Slutsky AS, Post M, Patterson GA: Assessment of postpreservation rat lung function
using a new model for extended venous reperfusion. J App Physiol 75(4):1890-1896, 1993.
Downar E, Masse S, Chen TCK, Mickleborough LL, Sevaptsidis E: An approach to three-dimensional mapping of
clinical ventricular arrhythmias. In: Cardiac Mapping. Shenasa M, Borggrefe M, Breithardt (Eds). Futura Publishing
Co., New York, 515-524, 1993.
Drasler WJ, Wilson GJ, Stenoien MD, Jenson ML, George SA, Dutcher RG, Possis ZC: A spun elastomeric graft
for dialysis access. ASAIL Journal 39(2):114-119, 1993.
Edelson JD, Chan S, Jassal D, Post M, Tanswell K: Vitamin D stimulates DNA synthesis in alveolar type II cells.
BBA 1221:159-166, 1994.
Ellis E, Koblin W, Irvine MJ, Legare J, Logan AG: Small, blue collar worksite hypertension screening. A cost
effectiveness study. J Occupational Med 36:346-355, 1994.
Epp TA, Dixon IM, Wang H-Y, Sole MJ, Liew C-C: Structural organization of the human cardiac -myosin heavy
chain gene (NYH6). Genomics 18:505-509, 1993.
Ettenson DS, Gotlieb AI: Centrosome dependent endothelial wound repair requires early transcription following
injury. Arteriosclerosis and Thrombosis 13:1270-1281, 1993.
Ettenson DS, Gotlieb AI: The role of endothelial cells in vascular integrity and repair in atherosclerosis. Adv in
Pathol and Lab Med 6:285-309, 1993.
Floras JS: Inhibitory effect of atrial natriuretic peptide on sympathetic ganglionic neurotransmission in humans. J
Hypertension 12(Suppl 3):S50, 1994.
Floras JS, Chen X: Will blood pressure variability diminish if baroreflex sensitivity is improved? J Hypertension
12(Suppl 3):S20, 1994.
Floras JS, Hara K: Sympathoneural and haemodynamic characteristics of young subjects with mild essential
hypertension. J Hypertension 11:647-655, 1993.
Floras JS: Clinical aspects of sympathetic activation and parasympathetic withdrawal in heart failure. J Am Col
Cardiol 22:72A-84A, 1993.
Forster C, Naik G, Armstrong PW: Noradrenaline biosynthesis and metabolism during development and recovery
from pacing-induced heart failure. Can J Physiol Pharmacol 72:45-49, 1994.
Forster C, Campbell PM: Nifedipine is able to selectively inhibit responses to alpha-stimulation in canine blood
vessels: enhanced effect in experimental heart failure. Eur J Pharmacol 242:119-129, 1993.
Forster C, Naik GOA, Larosa G: Myocardial -adrenoceptors in pacing-induced heart failure: Regulation by
enalapril? Can J Physiol Pharmacol 72:667-672, 1994.
Fraser WD, Goodman LS, Ackles KN, Mohn D, Pecaric M: Cardiovascular responses with standard and extended
coverage G-suits during rapid decompression. Aviat Space Environ Med 65:209-213, 1994.
Fremes SE, Furukawa RD, Li R-K, Weisel RD, Mickle DAG, Tumiati LC: Comparison of two experimental
models for assessment of cardiac function. Ann Thorac Surg 55:144-150, 1993.
Frohlich J, Brun LD, Blank D, Steiner G, et al: Comparison of the short term efficacy and tolerability of Lovastatin
and Simvastatin in the management of primary hypercholesterolemia. Can J Cardiol 9:405-412, 1993.
Gan K, Nishi I, Chin I, Slutsky AS: On-line determination of pulmonary blood flow using respiratory inert gas
analysis. IEEE Transaction on Biomed Engineering 40(12):1250-1259, 1993.
Gangbar E, Schwartz L, Gold W, Salit I: Infective endocarditis in a dairy farmer in association with bovine
Staphylococcus aureus mastitis. Can Vet J 34:677-678, 1993.
Gao Y, Burrows P, Benson L, Rabinovitch M, Freedom M: Scimitar syndrome in infancy. J Am Coll Cardiol
22:873-882, 1993.
Gemmell CH, Sefton M, Yeo EL: Platelet-derived microparticle formation involves GPIIb/IIIa: Inhibition by
RGDS and a Glanzmann's thrombastenic defect. J Biol Chem 268(20):14586-14589, 1993.
Goldberg H, Maxwell P, Hack N, Skorecki K: Reduced phospholipase A2 activity is not accompanied by reduced
arachidonic acid release. Biochem Biophys Res Comm 198:220, 1994.
Goodman LS, Fraser WD, Ackles KN, Mohn D, Pecaric M: Cardiovascular responses to prolonged positive
pressure breathing using standard vs. extended-coverage anti-G suits. Aviat Space Environ Med 64:1101-1107,
1993.
Goodman JM, Logan AG, McLaughlin PR, Laprade A, Liu PP: Atrial natriuretic peptide during acute and
prolonged exercise in well-trained men. Intl J Sports Med 14:185-190, 1993.
Goodman LS, Freeman MR, Yang L, Hsia TW, Chan J: Increased G-suit coverage improves cardiac preloading
conditions during positive pressure breathing. Aviat Space Environ Med 65:632-640, 1994.
Gow R, Bohn D, Koren G, Olley P, Rabinovitch M: Cardiovascular Pharmacology. In: Pediatric Pharmacology
and Therapeutics. IC Radde, SM MacLeod (Eds), 197-219, 1993.
Hack N, Sue-A-Quan A, Mills G, Skorecki K: Expression of human tyrosine kinase negative epidermal growth
factor receptor amplifies signaling through endogenous murine epidermal growth factor receptor. J Biol Chem
268:26441-26446, 1993.
Harris L, Kimura Y, Shaikh NA: Phospholipase inhibition and electrophysiology of acute ischemia: studies with
amiodarone. J Mol Cell Cardiol 25:1075-1090, 1993.
He G-W, Yang C-Q, Wilson GJ, Rebeyka IM: Tolerance of coronary endothelium and smooth muscle to
hyperkalemia. Ann Thorac Surg 57:682-688, 1994.
Hinek A, Rabinovitch M: The ductus arteriosus migratory smooth muscle cell phenotype processes tropoelastin to
a 52-kDa product associated with impaired assembly of elastic laminae. J Biol Chem 268:1405-1413, 1993.
Hinek A, Rabinovitch M: 67-kD elastin binding protein is a protective "companion" of extracellular insoluble
elastin and intracellular tropoelastin. J Cell Biol 126-563-574, 1994.
Hinek A, Rabinovitch M, Keeley F, Okamura-Oho Y, Callahan J: The 67 kD elastin/laminin-binding protein is
related to an alternately spliced form of -galactosidase. J Clin Invest 91:1198-1205, 1993.
Holmes DR Jr, Topol EJ, Adelman AG, Cohen EA, Califf RM: Randomized trials of directional coronary
atherectomy: Implications for clinical practice and future investigation. JACC 24:431-439, 1994.
Honrath U, Matsuda Y, Sonnenberg H: Cardiovascular and renal functional effects of an antagonist of the guanylyl
cyclase-linked ANF receptor. Regul Peptides 49:211-216, 1994.
Houde C, Bohn DJ, Freedom RM, Rabinovitch M: Profile of pediatric patients with pulmonary hypertension. Br
Heart J 70:461-468, 1993.
Ikonomidis JS, Weisel RD, Mickle DAG: Ischemic preconditioning: Cardioprotection for cardiac surgery. J
Cardiovasc Surg 9(Suppl):101-106, 1994.
Ikonomidis JS, Yau TM, Weisel RD, Hayashida N, Fu X, Ivanov J, Carson S, Mohabeer MK, Tumiati LC, Mickle
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