Usage of Human Famsbase for Nature 7 June 2007 Volume 447

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Nature7June2007Volume447Number7145pp613752
Nature 7 June 2007 Volume 447 Number 7145, pp613-752
Nature 7 June 2007 Volume 447 Number 7145, pp613-752
By Hideaki Umeyama
Usage of Human Famsbase for Nature 7 June 2007 Volume 447 Number 7145,
pp613-752
Articles
Top
Genome-wide association study of 14,000 cases of seven common diseases and 3,000
shared controls p661
An exciting genome-wide association study in the British population for seven common
diseases. This analysis confirms previously identified loci and provides strong evidence
for many novel disease susceptibility loci.
The Wellcome Trust Case Control Consortium
10.1038/nature05911
Abstract | Full Text | PDF
Dscam2 mediates axonal tiling in the Drosophila visual system p720
The role of Dscam2 (an immunoglobin superfamily protein) in regulating formation of
precise patterns of synaptic connections in the Drosophila visual system is described,
and shows for the first time that Dscam2 limits connections through a tiling mechanism
that involves homotypic repulsion.
S. Sean Millard et al.
The ATM repair pathway inhibits RNA polymerase I transcription in response to
chromosome breaks p730
DNA damage leads to transient repression of ribosomal gene transcription by RNA
polymerase I in a pathway mediated by ATM kinase activity and the DNA repair factors
Nbs1 and MDC1
Michael Kruhlak et al.
Control of DNA methylation and heterochromatic silencing by histone H2B
deubiquitination p735
In Arabidopsis chromatin, histone H2B is found to be monoubiquitinated, and the
ubiquitin protease SUP32/UBP26 is implicated in deubiquitinating H2B to establish
heterochromatic histone modification patterns.
Vaniyambadi V. Sridhar et al.
Nature7June2007Volume447Number7145pp613752
Nature 7 June 2007 Volume 447 Number 7145, pp613-752
Nature 7 June 2007 Volume 447 Number 7145, pp613-752
By Hideaki Umeyama
Usage of Human Famsbase for Nature 7 June 2007 Volume 447 Number 7145,
pp613-752
Articles
Top
Genome-wide association study of 14,000 cases of seven common diseases and 3,000
shared controls p661
An exciting genome-wide association study in the British population for seven common
diseases. This analysis confirms previously identified loci and provides strong
evidence for many novel disease susceptibility loci.
The Wellcome Trust Case Control Consortium
10.1038/nature05911
Abstract | Full Text | PDF
Dscam2 mediates axonal tiling in the Drosophila visual system p720
The role of Dscam2 (an immunoglobin superfamily protein) in regulating formation of
precise patterns of synaptic connections in the Drosophila visual system is
described, and shows for the first time that Dscam2 limits connections through a
tiling mechanism that involves homotypic repulsion.
S. Sean Millard et al.
1:
Q8TD84
Reports
Conserved Domains, Links
Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell
adhesion molecule 2)
gi|73620825|sp|Q8TD84|DSCL1_HUMAN[73620825]
1:
Q8TD84. Reports
Domains,
Down syndrome cel...[gi:73620825]
BLink, Conserved
Links
CommentFeaturesSequenceLOCUS
Q8TD84
2053 aa
linear
PRI 15-MAY-2007
DEFINITION Down syndrome cell adhesion molecule-like protein 1 precursor (Down
syndrome cell adhesion molecule 2).
ACCESSION
VERSION
DBSOURCE
Q8TD84
Q8TD84 GI:73620825
swissprot: locus DSCL1_HUMAN, accession Q8TD84;
class: standard.
extra accessions:Q76MU9,Q8IZY3,Q8IZY4,Q8WXU7,Q9ULT7
created: Aug 16, 2005.
sequence updated: Aug 16, 2005.
annotation updated: May 15, 2007.
1:
Q8TD84. Reports
Down syndrome cel...[gi:73620825]
BLink, Conserved
Domains,
Links
>gi|73620825|sp|Q8TD84|DSCL1_HUMAN
Down
syndrome
cell
adhesion
molecule-like protein
1 precursor (Down syndrome cell adhesion molecule 2)
MWLVTFLLLLDSLHKARPEDVGTSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSAAL
RWYLATGDDIYDV
PHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYT
VRVEDQRSMRGN
VAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCI
TKHKYSGETRQ
SNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPA
DSRWTKRITGLT
ISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALT
GSPEFTIRWYR
NTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPR
IVSSFSEKVVN
PGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGP
QIRDGGVYRCTARNL
VGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDN
HRQVVFENGTLK
LTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVV
SSGDMPIRITW
RKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVP
PRFVVQPNNQD
GIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRH
VLEEDIGYYLCQAS
NGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVI
DPDRVMRYAIA
TKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIRE
VKARSMNLRWTQR
FDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKI
GRSEPSKELTIS
TEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQ
YSIVEMKATGDSEV
YTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAV
ISWSEPPRSTLN
GVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGD
GVRSSVLYIQTKEDV
PGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLF
YRIAHLNRGQQ
YLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDP
APAVKWTKDSEDS
AIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPR
LTVSKTSASSIT
LTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAA
KNSVGSGRISEII
EAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQ
GLRANSSGEVFLTE
LREATWYELRMRACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGC
PVILATLGVALLF
IVRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIE
DKEGIKQLGDDKA
TIPVTDAEFSQAVNPQSFCTGVSLHHPTLIQSTGPLIDMSDIRPGTNPVSRKNVKSAH
STRNRYSSQWTL
TKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDTDKGRNSMVSTESASST
YEELARAYEHAKL
EEQLQHAKFEITECFISDSSSDQMTTGTNENADSMTSMSTPSEPGICRFTASPPKPQ
DADRGKNVAVPIP
HRANKSDYCNLPLYAKSEAFFRKADGREPCPVVPPREASIRNLARTYHTQARHLTL
DPASKSLGLPHPGA
PAAASTATLPQRTLAMPAPPAGTAPPAPGPTPAEPPTAPSAAPPAPSTEPPRAGGPHT
KMGGSRDSLLEM
STSGVGRSQKQGAGAYSKSYTLV
The ATM repair pathway inhibits RNA polymerase I transcription in response to
chromosome breaks p730
DNA damage leads to transient repression of ribosomal gene transcription by RNA
polymerase I in a pathway mediated by ATM kinase activity and the DNA repair factors
Nbs1 and MDC1
Michael Kruhlak et al.
8:
Q13315
Reports
Conserved Domains, Links
Serine-protein kinase ATM (Ataxia telangiectasia mutated) (A-T, mutated)
gi|13878337|sp|Q13315|ATM_HUMAN[13878337]
1: Q13315. Reports Serine-protein ki...[gi:13878337] BLink, Conserved Domains,
Links
CommentFeaturesSequenceLOCUS
Q13315
3056 aa
linear
PRI 15-MAY-2007
DEFINITION Serine-protein kinase ATM (Ataxia telangiectasia mutated) (A-T,
mutated).
ACCESSION
VERSION
Q13315
Q13315 GI:13878337
DBSOURCE
swissprot: locus ATM_HUMAN, accession Q13315;
class: standard.
extra accessions:O15429,Q12758,Q16551,Q93007,Q9NP02,Q9UCX7
created: Apr 27, 2001.
sequence updated: Nov 1, 1996.
annotation updated: May 15, 2007.
1: Q13315. Reports Serine-protein ki...[gi:13878337] BLink, Conserved Domains,
Links
>gi|13878337|sp|Q13315|ATM_HUMAN
Serine-protein
kinase
ATM
(Ataxia
telangiectasia
mutated) (A-T, mutated)
MSLVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSKQGKYLN
WDAVFRFLQKYIQK
ETECLRIAKPNVSASTQASRQKKMQEISSLVKYFIKCANRRAPRLKCQELLNYIMDT
VKDSSNGAIYGAD
CSNILLKDILSVRKYWCEISQQQWLELFSVYFRLYLKPSQDVHRVLVARIIHAVTKGC
CSQTDGLNSKFL
DFFSKAIQCARQEKSSSGLNHILAALTIFLKTLAVNFRIRVCELGDEILPTLLYIWTQH
RLNDSLKEVII
ELFQLQIYIHHPKGAKTQEKGAYESTKWRSILYNLYDLLVNEISHIGSRGKYSSGFRN
IAVKENLIELMA
DICHQVFNEDTRSLEISQSYTTTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQNDF
DLVPWLQIATQLI
SKYPASLPNCELSPLLMILSQLLPQQRHGERTPYVLRCLTEVALCQDKRSNLESSQK
SDLLKLWNKIWCI
TFRGISSEQIQAENFGLLGAIIQGSLVEVDREFWKLFTGSACRPSCPAVCCLTLALTTS
IVPGAVKMGIE
QNMCEVNRSFSLKESIMKWLLFYQLEGDLENSTEVPPILHSNFPHLVLEKILVSLTM
KNCKAAMNFFQSV
PECEHHQKDKEELSFSEVEELFLQTTFDKMDFLTIVRECGIEKHQSSIGFSVHQNLK
ESLDRCLLGLSEQ
LLNNYSSEITNSETLVRCSRLLVGVLGCYCYMGVIAEEEAYKSELFQKANSLMQCAG
ESITLFKNKTNEE
FRIGSLRNMMQLCTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDIADICKSLASFIKK
PFDRGEVESMED
DTNGNLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTIGAINPLAEEYLSKQDLL
FLDMLKFLCLCVTT
AQTNTVSFRAADIRRKLLMLIDSSTLEPTKSLHLHMYLMLLKELPGEEYPLPMEDV
LELLKPLSNVCSLY
RRDQDVCKTILNHVLHVVKNLGQSNMDSENTRDAQGQFLTVIGAFWHLTKERKYI
FSVRMALVNCLKTLL
EADPYSKWAILNVMGKDFPVNEVFTQFLADNHHQVRMLAAESINRLFQDTKGDSS
RLLKALPLKLQQTAF
ENAYLKAQEGMREMSHSAENPETLDEIYNRKSVLLTLIAVVLSCSPICEKQALFALC
KSVKENGLEPHLV
KKVLEKVSETFGYRRLEDFMASHLDYLVLEWLNLQDTEYNLSSFPFILLNYTNIEDF
YRSCYKVLIPHLV
IRSHFDEVKSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDSGMAQQRETATKV
YDMLKSENLLGK
QIDHLFISNLPEIVVELLMTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVIKA
TFAYISNCHKTK
LKSILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGG
AWAFVLRDVIY
TLIHYINQRPSCIMDVSLRSFSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLV
YEQVEVQKQVLD
LLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFL
SVSVYDALPLTR
LEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEK
EVLEAVGSCLGEVGP
IDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCL
KNILATKTGHSFW
EIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIK
TLTCAFLDSGGTK
CEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHF
SQTSRSTTPANLD
SESEHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQ
SCAAHFTALLYAEI
YADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSL
YGCGGGKMLQPI
TRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYE
NKDWCPELEELHY
QAAWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARVKEV
EEMCKRSLESVYSLY
PTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRT
VILEILMEKEMD
NSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQV
FWAKKEQSLALS
ILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEV
AGNYDGESSDELR
NGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLREHKIQTNR
YTVKVQRELELDEL
ALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMK
RDGMKIPTYKFLPLM
YQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPE
VARRSRITKNVPKQ
SSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIP
ADQPITKLKNLE
DVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVK
GRDDLRQDAVMQQ
VFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDG
AHKRYRPNDFSAFQ
CQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRS
VATSSIVGYILGLGD
RHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFR
RCCEKTMEVMRN
SQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLS
DIDQSFDKVAERVL
MRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV
Nbs1
11:
O60934
Reports
Conserved Domains, Links
Nibrin (Nijmegen breakage syndrome protein 1) (Cell cycle regulatory protein p95)
gi|74762960|sp|O60934|NBN_HUMAN[74762960]
FEATURES
source
Location/Qualifiers
1..754
/organism="Homo sapiens"
/db_xref="taxon:9606"
gene
1..754
/gene="NBN"
/note="synonyms: NBS, NBS1, P95"
Protein
1..754
/gene="NBN"
/product="Nibrin"
Region
1..754
/gene="NBN"
/region_name="Mature chain"
/experiment="experimental evidence, no additional details
recorded"
/note="Nibrin. /FTId=PRO_0000231043."
1: O60934. Reports Nibrin (Nijmegen ...[gi:74762960] BLink, Conserved Domains,
Links
>gi|74762960|sp|O60934|NBN_HUMAN Nibrin (Nijmegen breakage syndrome
protein 1) (Cell
cycle regulatory protein p95)
MWKLLPAAGPAGGEPYRLLTGVEYVVGRKNCAILIENDQSISRNHAVLTANFSVTNL
SQTDEIPVLTLKD
NSKYGTFVNEEKMQNGFSRTLKSGDGITFGVFGSKFRIEYEPLVACSSCLDVSGKTA
LNQAILQLGGFTV
NNWTEECTHLVMVSVKVTIKTICALICGRPIVKPEYFTEFLKAVESKKQPPQIESFYP
PLDEPSIGSKNV
DLSGRQERKQIFKGKTFIFLNAKQHKKLSSAVVFGGGEARLITEENEEEHNFFLAPG
TCVVDTGITNSQT
LIPDCQKKWIQSIMDMLQRQGLRPIPEAEIGLAVIFMTTKNYCDPQGHPSTGLKTTT
PGPSLSQGVSVDE
KLMPSAPVNTTTYVADTESEQADTWDLSERPKEIKVSKMEQKFRMLSQDAPTVKES
CKTSSNNNSMVSNT
LAKMRIPNYQLSPTKLPSINKSKDRASQQQQTNSIRNYFQPSTKKRERDEENQEMS
SCKSARIETSCSLL
EQTQPATPSLWKNKEQHLSENEPVDTNSDNNLFTDTDLKSIVKNSASKSHAAEKLR
SNKKREMDDVAIED
EVLEQLFKDTKPELEIDVKVQKQEEDVNVRKRPRMDIETNDTFSDEAVPESSKISQE
NEIGKKRELKEDS
LWSAKEISNNDKLQDDSEMLPKKLLLTEFRSLVIKNSTSRNPSGINDDYGQLKNFK
KFKKVTYPGAGKLP
HIIGGSDLIAHHARKNTELEEWLRQEMEVQNQHAKEESLADDLFRYNPYLKRRR
and MDC1
19:
Q14676
Reports
Conserved Domains, Links
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
gi|68565390|sp|Q14676|MDC1_HUMAN[68565390]
1: Q14676. Reports Mediator of DNA d...[gi:68565390] BLink, Conserved Domains,
Links
CommentFeaturesSequenceLOCUS
linear
PRI 15-MAY-2007
Q14676
2089 aa
DEFINITION Mediator of DNA damage checkpoint protein 1 (Nuclear factor with
BRCT domains 1).
ACCESSION
VERSION
DBSOURCE
Q14676
Q14676 GI:68565390
swissprot: locus MDC1_HUMAN, accession Q14676;
class: standard.
extra accessions:Q5JP55,Q5JP56,Q5ST83,Q68CQ3,Q86Z06,Q96QC2
created: Jul 5, 2005.
sequence updated: Jul 5, 2005.
annotation updated: May 15, 2007.
1: Q14676. Reports Mediator of DNA d...[gi:68565390] BLink, Conserved Domains,
Links
>gi|68565390|sp|Q14676|MDC1_HUMAN Mediator of DNA damage checkpoint
protein 1
(Nuclear factor with BRCT domains 1)
MEDTQAIDWDVEEEEETEQSSESLRCNVEPVGRLHIFSGAHGPEKDFPLHLGKNV
VGRMPDCSVALPFPS
ISKQHAEIEILAWDKAPILRDCGSLNGTQILRPPKVLSPGVSHRLRDQELILFADLLC
QYHRLDVSLPFV
SRGPLTVEETPRVQGETQPQRLLLAEDSEEEVDFLSERRMVKKSRTTSSSVIVPESD
EEGHSPVLGGLGP
PFAFNLNSDTDVEEGQQPATEEASSAARRGATVEAKQSEAEVVTEIQLEKDQPLVKE
RDNDTKVKRGAGN
GVVPAGVILERSQPPGEDSDTDVDDDSRPPGRPAEVHLERAQPFGFIDSDTDAEEER
IPATPVVIPMKKR
KIFHGVGTRGPGAPGLAHLQESQAGSDTDVEEGKAPQAVPLEKSQASMVINSDTDD
EEEVSAALTLAHLK
ESQPAIWNRDAEEDMPQRVVLLQRSQTTTERDSDTDVEEEELPVENREAVLKDHTK
IRALVRAHSEKDQP
PFGDSDDSVEADKSSPGIHLERSQASTTVDINTQVEKEVPPGSAIIHIKKHQVSVEGT
NQTDVKAVGGPA
KLLVVSLEEAWPLHGDCETDAEEGTSLTASVVADVRKSQLPAEGDAGAEWAAAVLK
QERAHEVGAQGGPP
VAQVEQDLPISRENLTDLVVDTDTLGESTQPQREGAQVPTGREREQHVGGTKDSED
NYGDSEDLDLQATQ
CFLENQGLEAVQSMEDEPTQAFMLTPPQELGPSHCSFQTTGTLDEPWEVLATQPFC
LRESEDSETQPFDT
HLEAYGPCLSPPRAIPGDQHPESPVHTEPMGIQGRGRQTVDKVMGIPKETAERVGP
ERGPLERETEKLLP
ERQTDVTGEEELTKGKQDREQKQLLARDTQRQESDKNGESASPERDRESLKVEIET
SEEIQEKQVQKQTL
PSKAFEREVERPVANRECDPAELEEKVPKVILERDTQRGEPEGGSQDQKGQASSPT
PEPGVGAGDLPGPT
SAPVPSGSQSGGRGSPVSPRRHQKGLLNCKMPPAEKASRIRAAEKVSRGDQESPDA
CLPPTVPEAPAPPQ
KPLNSQSQKHLAPPPLLSPLLPSIKPTVRKTRQDGSQEAPEAPLSSELEPFHPKPKIR
TRKSSRMTPFPA
TSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQPV
TSEPTSQVTRGR
KSRSSVKTPETVVPTALELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAP
ELQPSTSTDQPV
TSEPTYQATRGRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTNMSS
VKTPETVVPTAP
ELQISTSTDQPVTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPSTSTEQPVTPEPTS
RATRGRKNRSS
GKTPETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPTAPELQPS
TSTDQPVTPEPT
SQATRGRTDRSSVKTPETVVPTAPELQASASTDQPVTSEPTSRTTRGRKNRSSVKTP
ETVVPAAPELQPS
TSTDQPVTPEPTSRATRGRTNRSSVKTPESIVPIAPELQPSTSRNQLVTPEPTSRATRC
RTNRSSVKTPE
PVVPTAPEPHPTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPVEPAASDLEPFTPTDQ
SVTPEAIAQGGQ
SKTLRSSTVRAMPVPTTPEFQSPVTTDQPISPEPITQPSCIKRQRAAGNPGSLAAPID
HKPCSAPLEPKS
QASRNQRWGAVRAAESLTAIPEPASPQLLETPIHASQIQKVEPAGRSRFTPELQPKAS
QSRKRSLATMDS
PPHQKQPQRGEVSQKTVIIKEEEEDTAEKPGKEEDVVTPKPGKRKRDQAEEEPNRI
PSRSLRRTKLNQES
TAPKVLFTGVVDARGERAVLALGGSLAGSAAEASHLVTDRIRRTVKFLCALGRGIPIL
SLDWLHQSRKAG
FFLPPDEYVVTDPEQEKNFGFSLQDALSRARERRLLEGYEIYVTPGVQPPPPQMGEI
ISCCGGTYLPSMP
RSYKPQRVVITCPQDFPHCSIPLRVGLPLLSPEFLLTGVLKQEAKPEAFVLSPLEMSS
T
Control of DNA methylation and heterochromatic silencing by histone H2B
deubiquitination p735
In Arabidopsis chromatin, histone H2B is found to be monoubiquitinated, and the
ubiquitin protease SUP32/UBP26 is implicated in deubiquitinating H2B to establish
heterochromatic histone modification patterns.
Vaniyambadi V. Sridhar et al.
SUP32
/UBP26
1:
NP_566922
Reports
Conserved Domains, Links
UBP26 (ubiquitin-specific protease 26); ubiquitin-specific protease [Arabidopsis
thaliana]
gi|18408899|ref|NP_566922.1|[18408899]
1:
NP_566922. Reports
UBP26 (ubiquitin-...[gi:18408899]
BLink, Conserved
Domains,
Links
CommentFeaturesSequenceLOCUS
NP_566922
1067 aa
linear
PLN 20-APR-2007
DEFINITION UBP26 (ubiquitin-specific protease 26); ubiquitin-specific protease
[Arabidopsis thaliana].
ACCESSION
VERSION
NP_566922
NP_566922.1 GI:18408899
DBSOURCE
REFSEQ: accession NM_114820.3
KEYWORDS
.
SOURCE
Arabidopsis thaliana (thale cress)
ORGANISM Arabidopsis thaliana
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
COMMENT
PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AT3G49600.1p.
Method: conceptual translation.
FEATURES
source
Location/Qualifiers
1..1067
/organism="Arabidopsis thaliana"
/db_xref="taxon:3702"
/chromosome="3"
/ecotype="Columbia"
Protein
1..1067
/product="UBP26 (ubiquitin-specific protease 26);
ubiquitin-specific protease"
/calculated_mol_wt=119803
Region
107..440
/region_name="Peptidase_C19L"
/note="A subfamily of Peptidase C19. Peptidase C19
contains ubiquitinyl hydrolases. They are intracellular
peptidases that remove ubiquitin molecules from
polyubiquinated peptides by cleavage of isopeptide bonds;
cd02668"
/db_xref="CDD:73074"
Region
522..597
/region_name="DUSP"
/note="Domain in ubiquitin-specific proteases; smart00695"
/db_xref="CDD:47965"
Region
960..1027
/region_name="UBL"
/note="UBLs function by remodeling the surface of their
target proteins, changing their target's half-life,
enzymatic activity, protein-protein interactions,
subcellular localization or other properties; cd01769"
/db_xref="CDD:29171"
CDS
1..1067
/gene="UBP26"
/locus_tag="AT3G49600"
/coded_by="NM_114820.3:205..3408"
/GO_component="cellular_component"
/GO_function="ubiquitin-specific protease activity"
/GO_process="protein modification; ubiquitin cycle;
ubiquitin-dependent protein catabolic process"
/note="similar to UBP12 (UBIQUITIN-SPECIFIC PROTEASE
12),
ubiquitin-specific protease [Arabidopsis thaliana]
1:
NP_566922. Reports
UBP26 (ubiquitin-...[gi:18408899]
BLink, Conserved
Domains,
Links
>gi|18408899|ref|NP_566922.1| UBP26 (ubiquitin-specific protease 26); ubiquitinspecific protease [Arabidopsis thaliana]
MSRPNTRNKNKRQRPDAVDSSSQILRKIHEANDVTDDDINQLFMIWKPVCQGCRVN
TRDNPNCFCGLVPP
LNGSRKSGLWQKTSEIIQSLGPDPTLDRRDSESTPAGLTNLGATCYANSILQCLYMNT
AFREGVFSVEVH
VLKQNPVLDQIARLFAQLHASQKSFVDSDAFVKTLELDNGVQQDTHEFLTLLLSLLE
RCLLHSGVKAKTI
VQDLFSGSVSHVTTCSKCGRDSEASSKMEDFYALELNVKGLKSLDASLNDYLSLEQ
LNGDNQYFCGSCNA
RVDATRCIKLRTLPPVITFQLKRCIFLPKTTAKKKITSSFSFPQVLDMGSRLAESSQN
KLTYDLSAVLIH
KGSAVNSGHYVAHIKDEKTGLWWEFDDEHVSELGKRPCNEASSSTPQSESNGTASS
GNITDGIQSGSSDC
RSAIKSEVFSSSDAYMLMYSLRCDKQENQEGQKENPIDITKGEVKQLKGGYLPKHL
SEWINNMNAVFLES
CKQYNLRKEKELNALTERRQEVRTILSEAAVQSLEEQYFWISTDWLRLWADTTLPPA
LDNTPLLCSHGKV
HASKVNCMKRISELAWIKLESKFNGGPKLGKGDYCRDCLMDGARMVVSSDSYRDR
RTFMKSIANDVLSGK
CEDGMYYISRAWLQQWIKRKNLDAPTEADAGPTNAITCNHGELMPEQAPGAKRVV
VPENFWSFLFEDALK
VMSEDTLDCTCFPVDSSQCCHCTEVLSEVACFEDSLRTLKVKQRQNHEKLATGKGI
PLTPQSRYFLLPSP
WLVQWRIYINMTGKNSSSAPEPERLDGVINTLKCKKHTRLLERLPELVCRRGSYFQ
KNPSTDKLTIIPEL
DWKYFCDEWGGLMENGISAFIEVGNTDQSSSPDVIDLEKDSSPDDNMDVDAQQLIL
RASPEICEECIGER
ESCELMQKLSYSEGDVFVCFVRGKEAPKAMLEASDSSFEVDRRTSKRSRRTNYGNL
TSLKVSATTTVYQL
KMMIWELLGVMKENQELHKGSKVIDQESATLADMNIFPGDRLWVRDTEMHEHRD
IADELCEKKPGAQDIE
EGFRGTLLTGNISSEAC
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