Principal Investigator/Program Director (Last, First, Middle):
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
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NAME
POSITION TITLE
Louise M. Ball
Professor
eRA COMMONS USER NAME
lmball
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
University of Bristol, Bristol, U.K.
University of London, London, U.K.
National Institute of Environmental Health Sciences,
Research Triangle Park, NC, USA
DEGREE
(if applicable)
B.Sc.
Ph.D.
Post-doctoral
Fellowship
YEAR(s)
1972
1976
1976-1979
FIELD OF STUDY
Biochemistry
Biochemistry
Biochemical Toxicology
A. Positions and Honors
1979-1980
1981
1981-1984
1984-1986
1986-1993
1993-date
1993-1999
1999-date
2000-date
NIH Visiting Associate, Laboratory of Pharmacology, NIEHS, Research Triangle Park, NC, U.S.A.
Research Assistant Professor, Department of Pharmacology, Duke University, Durham, NC.
National Research Council Resident Research Associate, Health Effects Research Laboratory, U.S.
Environmental Protection Agency, Research Triangle Park, NC.
Research Associate, Department of Environmental Sciences and Engineering, University of North Carolina
Assistant Professor, Department of Environmental Sciences and Engineering, School of Public Health,
University of North Carolina at Chapel Hill, NC.
Director, Environmental Health Sciences Program, Department of Environmental Sciences and
Engineering, School of Public Health, University of North Carolina at Chapel Hill, NC.
Associate Professor, Department of Environmental Sciences and Engineering, School of Public Health,
University of North Carolina at Chapel Hill, NC.
Professor, Department of Environmental Sciences and Engineering, School of Public Health, University of
North Carolina at Chapel Hill, NC.
Ad hoc reviewer, NIH-NIGMS, Minority Biomedial Research Support, Chemistry Panel
B. Selected peer-reviewed publications (selected from 68)
Ball, L.M., Renwick, A.G. and Williams, R.T. The fate of [14C]saccharin in man, rat, and rabbit, and of 2sulphamoyl[14C]benzoic acid in the rat. Xenobiotica 7: 189-203, 1977.
Ball, L.M., Williams, R.T. and Renwick, A.G. The fates of saccharin impurities: The excretion and metabolism of
[14C]toluene-4-sulphonamide and 4-sulphamoyl[14C]benzoic acid in the rat. Xenobiotica 8: 183-190, 1978.
Renwick, A.G., Ball, L.M., Corina, D.L. and Williams, R.T. The fate of saccharin impurities: The excretion and
metabolism of toluene-2-sulphonamide in man and rat. Xenobiotica 8: 461-474, 1978.
Wolf, C.R., Smith, B.R., Ball, L.M., Serabjit-Singh, C., Bend, J.R. and Philpot, R.M. The rabbit pulmonary monooxygenase systems: Catalytic differences between two purified forms of cytochrome P-450 in the metabolism of
benzo(a)pyrene. J. Biol. Chem. 254: 3658-3663, 1979.
Ball, L.M., Kohan, M.J., Inmon, J., Claxton, L.D. and Lewtas, J. Metabolism of 1-nitro[14C]pyrene in vivo in the rat and
mutagenicity of urinary metabolites. Carcinogenesis 5: 1557-1564, 1984.
Ball, L.M., Kohan, M.J., Claxton, L.D. and Lewtas, J. Mutagenicity of derivatives and metabolites of 1-nitropyrene;
activation by rat liver S9 compared to bacterial enzymes. Mutat. Res. 138: 113-125, 1984.
Dietrich, A.M., Guenat, C.R., Tomer, K.B. and Ball, L.M. Identification and characterization of the major DNA adduct
formed chemically and in vitro from the environmental genotoxin 3-nitrofluoranthene. Carcinogenesis 9: 2113-2119,
1988.
Ball, L.M., Rafter, J.J., Gustafsson, J.-A., Gustafsson, B.-E., Kohan, M.J., and Lewtas, J. Formation of mutagenic urinary
metabolites from 1-Nitropyrene in germ-free and conventional rats: Role of the gut flora. Carcinogenesis 12: 1-5,
1991.
Ball, L.M., Warren, S.H., Sangaiah, R. and Gold, A. Bacterial mutagenicity of two cyclopentafused isomers of
benzpyrene. Mutat. Res. 260: 271-279, 1991.
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Principal Investigator/Program Director (Last, First, Middle):
Sangaiah, R., Gold, A., Ball, L.M., Matthews, D.L. and Toney, G.E. Synthesis and resolution of putative diastereomeric
N2-Deoxyguanosine and N6-Deoxyadenosine adducts of biologically active CyclopentaPAH. Tetrahedron Lett. 33:
5487-5490, 1992.
Cozzie, D.A., Kanniganti, R., Charles, M.J., Johnson, J.D. and Ball, L.M. Formation and characterization from reaction of
the alternative disinfectant monochloramine with model aqueous solutions of fulvic acid. Environ. Molecular Mutag.
21: 237-246, 1993.
Holloway, T.C. and Ball, L.M. Synthesis and mutagenicity of a series of nitrated carbazoles and hydroxycarbazoles.
Mutagenesis 8: 321-327, 1993.
Newcomb, K.O., Sangaiah, R., Gold, A. and Ball, L.M. Activation and metabolism of benz[j]aceanthrylene-9,10dihydrodiol, the precursor to bay-region metabolism of the genotoxic cyclopenta-PAH benz[j]aceanthrylene. Mutation
Res. 287: 181-190, 1993.
Ball, L.M., Rosser-Duncan, P. and Boucher, M.N. Oxidative and bacterial pathways in metabolic activation of nitrated
polycyclic aromatic hydrocarbons. In: Polycyclic Aromatic Compounds, Gordon and Breach Publishers, Langhorne,
PA, Vol. 7, pp. 35-42, 1994.
Ball, L.M., Stocking, L.M., Kohan, M.J., Warren, S.H. and Lewtas, J. Metabolic activation of the genotoxic environmental
contaminants 2- and 3-Nitrofluoranthene in variants of Salmonella typhimurium. Mutagenesis 10: 497-504, 1995.
Sangaiah, R., Ramachandran, P., Zhang, J. and Ball, L.M. Synthesis and biological activity of metabolites of
environmental nitroarenes. Polycyclic Aromatic Compounds 11: 283-290, 1996.
Rosser, P.F., Ramachandran, P., Sangaiah, R., Austin, R.N., Gold, A. and Ball, L.M. Role of O-acetyltransferase in
activation of oxidised metabolites of the genotoxic environmental pollutant 1-Nitropyrene. Mutat. Res. 369: 209-220,
1996.
Sangaiah, R., Christova-Georguieva, N.I., Ranasinghe, A., Tretyakova, N., Gold, A., Ball, L.M., and Swenberg, J.A.
Synthesis of perdeuterated analogues of the epoxide metabolites of butadiene: 1,2-epoxybut-3-ene-d6 and 1,2,3,4diepoxybutane-d6. J. Labelled Compds. Radiopharm. 39: 731-739, 1997.
Gold, A., Jayaraj, K., Ball, L.M., and Brust, K.: Oxidation of polycyclic aromatic hydrocarbons by an oxoferryl porphyrin cation radical. J. Molec. Catal. A: Chemical 125: 23-32, 1997.
Hertz-Picciotto, I., Korte, J., Schulz, M., Chiang, T.-C., and Ball, L.M. Comment: Carbon black risk assessment
comparison is flawed. Reg. Toxicol. and Pharm. 26: 338-339, 1997.
Prusiewicz, C.M., Sangaiah, R., Gold, A and Ball, L.M. Synthesis of 3'-phosphate adducts of cyclopenta[cd]pyrene with
deoxyguanosine via 3'-H-phosphonate intermediates. Polycyc. Arom. Cmpds 17: 11-20, 1999.
Korte, J.E., Hertz-Picciotto, I., Schulz, M.R., Ball, L.M., and Duell, E.J. The contribution of benzene to smoking-induced
leukemia. Environ. Hlth. Perspect. 108: 333-339, 2000.
Jayaraj, K., Gold, A., Ball, L.M. and White, P.S. N-Porphyrinylamino and -amido compounds by addition of an amino or
amido nitrogen to a porphyrin meso position. Inorg. Chem. 39: 3652-3664, 2000.
Schulz, M.R., Hertz-Picciotto, I., Todd, L. and Ball, L.M. Reconciling animal and human data in a cancer risk assessment
of acrylonitrile. Scand. J. Work Env Health 27: 14-20, 2001.
Schulz, M.R., Hertz-Picciotto, I., van Wijngaarden, E., Hernandez, J.C., and Ball, L.M. Dose-response relation between
acrylamide and pancreatic cancer.[comment]. Occupational & Environmental Medicine 58(9): 609, 2001.
Jayaraj, K., Gold, A., Sangaiah, R., Georgieva, N., Koc, H., Klapper, D.G., Ball, L.M., Reddy, A.P. and Swenberg, J.A.
Synthesis and characterization of peptides containing a cyclic valine adduct of diepoxybutane, a possible biomarker of
human exposure to butadiene. Chem. Res. Toxicol. 16(5): 637-643, 2003.
Gold, A., Nam, T.-G., Jayaraj, K., Sangaiah, R., Klapper, D.G., Ball, L.M., French, J.E., and Nylander-French, L.A.
Synthesis of S-Aryl-D,L-Cysteines and incorporation into keratin sequences. Organic Preparations and Procedures Int.
35(4): 375-381, 2003.
Powley, M.W., Jayaraj, K., Gold, A., Ball, L.M., and Swenberg, J.A. 1,N2-propanodeoxyguanosine adducts of the 1,3butadiene metabolite, hydroxymethylvinyl ketone. Chem. Res. Toxicol. 16: 1448-1454, 2003.
Lin, P.-H., Sangaiah, R., Ranasinghe, A., Ball, L.M., Swenberg, J.A. and Gold, A. Synthesis of Chlorinated and Nonchlorinated Biphenyl-2,3- and 3,4-catechols and their [2H3]-isotopomers. Organic Biomolec. Chem. 2: 2624-9, 2004.
Casteel, M.J., Jayaraj, K., Gold, A., Ball, L.M., and Sobsey, M.D. Photoinactivation of Hepatitis A Virus by Synthetic
Porphyrins. Photochem. Photobiol., 80: 294-300, 2004.
Jeong, Y.-C., Sangaiah, R., Nakamura, J., Pachkowski, B.F., Ranasinghe, A., Gold, A., Ball, L.M. and Swenberg, J.A.
Analysis of M1G-dR in DNA by ARP Labeling and LC-MS/MS. Chem. Res. Toxicol.,18: 51-60, 2005.
Singleton, D.R., Powell, S.N., Sangaiah, R., Gold, A., Ball, L.M., and Aitken, M.D. Stable-Isotope Probing of Bacteria
Capable of Degrading Salicylate, Naphthalene, or Phenanthrene in a Bioreactor Treating Contaminated Soil. Applied
and Environmental Microbiology, 71(3): 1202-1209, 2005.
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Principal Investigator/Program Director (Last, First, Middle):
C. Research Support
Ongoing
R01 OH07598 L. Nylander-French (PI)
08/01/2003 - 07/31/2006
NIOSH
Dermal Exposure to 1,6-Hexamethylene Diisocyanate
The major goal of this project is to develop measures of exposure to hexamethylene diisocyanate.
Role: Co-investigator
CT8247101 L.M. Ball (PI)
09/10/2001 - 09/09/2006
U.S. Environmental Protection Agency
NHEERL-DESE Cooperative Training in Environmental Sciences Research
The purpose of this project is to continue a cooperative training program in environmental health sciences between the
National Health and Environmental Effects Research Laboratory, U.S. EPA, and the Department of Environmental
Sciences and Engineering, UNC-Chapel Hill.
Role: PI
5P42-ES05948 J. Swenberg (PI)
04/01/2000 - 03/31/2006
NIH/NIEHS
Environmental Exposure and Effect of Hazardous Chemicals (Chemistry Core)
The overall aims are to investigate fate, movement and mechanisms of biological activity of hazardous chemicals,
principally Superfund-related chlorinated hydrocarbons in the environment. The Chemistry Core laboratory supplies
standards, synthesizes labeled compounds and act as a resource in the development of analytical procedures for
measuring protein and DNA adducts as markers for exposure.
Role: PI and Director, Chemistry Core
Completed
CT826513 L.M. Ball (PI)
04/29/1998 - 04/28/2004
U.S. Environmental Protection Agency
NHEERL-DESE Cooperative Training in Environmental Sciences Research
The purpose of this project was to establish a cooperative training program in environmental health sciences between
the National Health and Environmental Effects Research Laboratory, U.S. EPA, and the Department of Environmental
Sciences and Engineering, UNC-Chapel Hill.
Role: PI
R825957 L.M. Ball (PI)
01/23/1998 - 01/22/2002
U.S. Environmental Protection Agency
Metabolic Fate of Halogenated Disinfection By-Products in vivo, and Relation to Biological Activity
The purpose of this research was to identify major urinary metabolites and macromolecular adducts of disinfection byproducts that may be informative with respect to their mechanism of biological activity and also serve as indicators of
exposure.
Role: PI
U60-CCU415922-01 I. Hertz-Picciotto (PI)
09/30/1998 - 09/29/2001
CDC/NIOSH
Evaluating Animal-based Predictions Using Epidemiology
The purpose of this research was to evaluate occupational carcinogens for which there are both animal toxicological
studies and adequate epidemiologic studies with which the risks extrapolated from animal data can be systematically
compared.
Role: Co-investigator
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Principal Investigator/Program Director (Last, First, Middle):
Completed
R825346 L.M. Ball (PI)
11/18/1996 - 11/17/1999
U.S. Environmental Protection Agency
Heme Adducts from NitroPAH: Characterization and Mechanisms of Formation
The purpose of this research was to characterize adducts formed from reaction of 1-nitropyrene and other nitroPAH
with hemoglobin heme, and investigate their utility as biomarkers of exposure.
Role: PI
R01-ES06692 A. Gold (PI)
08/01/1994 - 07/31/1999
NIH/NIEHS
Ki-ras Activation and Adduct Formation by CyclopentaPAH
The purpose of this project was to relate formation of DNA adducts by cyclopentaPAH to activation of the Ki-ras
protooncogene in strain A/J mouse lung tumors induced by cyclopentaPAH.
Role: Co-investigator
5R01ES005732 L.M. Ball (PI)
09/30/1992 - 09/29/1997
NIH/NIEHS
Metabolic Activation of Nitrated PAH
The purpose of this project was to investigate the pathways by which nitrated polycyclic aromatic hydrocarbons
undergo metabolic activation.
Role: PI
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