Jones and Bartlett Publishers
Genetics: Analysis of Genes and Genomes, Seventh Edition
Daniel L. Hartl and Elizabeth W. Jones
BRIEF CONTENTS
Preface
Acknowledgements
About the Authors
In Memoriam
About the Cover
xv
xxiii
xxvi
xxvii
xxviii
1
Genes, Genomes, and Genetic Analysis
1
2
DNA Structure and Genetic Variation
38
3
Transmission Genetics: The Principle of Segregation
77
4
Chromosomes and Sex-Chromosome Inheritance
114
5
Genetic Linkage and Chromosome Mapping
150
6
Molecular Biology of DNA Replication and Recombination
190
7
Molecular Organization of Chromosomes
221
8
Human Karyotypes and Chromosome Behavior
251
9
Genetics of Bacteria and Their Viruses
295
10
Molecular Biology of Gene Expression
341
11
Molecular Mechanisms of Gene Regulation
380
12
Genomics, Proteomics, and Transgenics
431
13
Genetic Control of Development
471
14
Molecular Mechanisms of Mutation and DNA Repair
509
15
Molecular Genetics of the Cell Cycle and Cancer
551
16
Mitochondrial DNA and Extranuclear Inheritance
587
17
Molecular Evolution and Population Genetics
611
18
The Genetic Basis of Complex Traits
651
Answers to Even-Numbered Problems
Further Readings
Word Roots
Concise Dictionary of Genetics
Index
683
701
705
709
735
(FULL TABLE OF CONTENTS ON REVERSE)
© 2009 Jones and Bartlett Publishers, LLC
08/12/08
FULL CONTENTS
1 Genes, Genomes, and Genetic Analysis
1.1 DNA: The Genetic Material
1.2 DNA Structure and Replication
1.3 Genes and Proteins
1.4 Genetic Analysis
1.5 Gene Expression: The Central Dogma
1.6 Mutation
1.7 Genes and Environment
1.8 The Molecular Unity of Life
2 DNA Structure and Genetic Variation
2.1 Genetic Differences Among Individuals
2.2 The Molecular Structure of DNA
2.3 The Separation and Identification of Genomic DNA Fragments
2.4 Selective Replication of Genomic DNA Fragments
2.5 The Terminology of Genetic Analysis
2.6 Types of DNA Markers Present in Genomic DNA
2.7 Applications of DNA Markers
3 Transmission Genetics: The Principle of Segregation
3.1 Morphological and Molecular Phenotypes
3.2 Segregation of a Single Gene
3.3 Segregation of Two or More Genes
3.4 Probability in Genetic Analysis
3.5 Human Pedigree Analysis
3.6 Incomplete Dominance and Epistasis
4 Chromosomes and Sex-Chromosome Inheritance
1
2
6
10
14
21
26
28
29
38
39
40
47
55
60
62
68
77
78
80
87
90
97
101
114
4.1 The Stability of Chromosome Complements
4.2 Mitosis
4.3 Meiosis
4.4 Sex-Chromosome Inheritance
4.5 Probability in the Prediction of Progeny Distributions
4.6 Testing Goodness of Fit to a Genetic Hypothesis
115
116
119
128
136
139
5 Genetic Linkage and Chromosome Mapping
150
5.1 Linkage and Recombination of Genes in a Chromosome
5.2 Genetic Mapping
Chromosomes
5.3 Genetic Mapping in a Three-Point Testcross
5.4 Genetic Mapping in Human Pedigrees
5.5 Mapping by Tetrad Analysis
5.6 Special Features of Recombination
6 Molecular Biology of DNA Replication and
Recombination
6.1 Problems of Initiation, Elongation, and Incorporation Error
6.2 Semiconservative Replication of Double-Stranded DNA
6.3 Unwinding, Stabilization, and Stress Relief
6.4 Initiation by a Primosome Complex
6.5 Chain Elongation and Proofreading
6.6 Discontinuous Replication of the Lagging Strand
6.7 Terminator Sequencing of DNA
6.8 Molecular Mechanisms of Recombination
7 Molecular Organization of Chromosomes
7.1 Genome Size and Evolutionary Complexity: The C-Value Paradox
7.2 The Supercoiling of DNA
7.3 The Structure of Bacterial Chromosomes
7.4 The Structure of Eukaryotic Chromosomes
7.5 Polytene Chromosomes
7.6 Repetitive Nucleotide Sequences in Eukaryotic Genomes
7.7 Unique and Repetitive Sequences in Eukaryotic Genomes
7.8 Molecular Structure of the Centromere
7.9 Molecular Structure of the Telomere
8 Human Karyotypes and Chromosome Behavior
8.1 The Human Karyotype
8.2 Chromosome Abnormalities in Human Pregnancies
8.3 Chromosomal Deletions and Duplications
8.4 Genetics of Chromosomal Inversions
8.5 Chromosomal Translocations
8.6 Genomic Position Effects on Gene Expression
8.7 Polyploidy in Plant Evolution
8.8 Genome Evolution in the Grass Family (Gramineae)
9 Genetics of Bacteria and Their Viruses
9.1 Mobile DNA
9.2 Bacterial Genetics
9.3 DNA-Mediated Transformation
9.4 Conjugation
9.5 Transduction
© 2009 Jones and Bartlett Publishers, LLC
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9.6 Bacteriophage Genetics
9.7 Lysogeny and Specialized Transduction
10 Molecular Biology of Gene Expression
10.1 Amino Acids, Polypeptides, and Proteins
10.2 Colinearity Between Coding Sequences and Polypeptides
10.3 Transcription
10.4 Messenger RNA
10.5 RNA Processing in Eukaryotes
10.6 Translation
10.7 Complex Translation Units
10.8 The Standard Genetic Code
316
325
341
342
344
344
350
352
358
366
368
11 Molecular Mechanisms of Gene Regulation
380
11.1 Transcriptional Regulation in Prokaryotes
11.2 The Operon System of Gene Regulation
11.3 Regulation Through Transcription Termination
11.4 Regulation in Bacteriophage Lambda
11.5 Transcriptional Regulation in Eukaryotes
11.6 Epigenetic Mechanims of Transcriptional Regulation
11.7 Regulation Through RNA Processing and Decay
11.8 RNA Interference
11.9 Translational Control
11.10 Programmed DNA Rearrangements
381
383
392
396
398
409
413
414
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419
12 Genomics, Proteomics, and Transgenics
431
12.1 Site-Specific DNA Cleavage and Cloning Vectors
12.2 Cloning Strategies
12.3 Detection of Recombinant Molecules
12.4 Genomics and Proteomics
12.5 Transgenic Organisms
12.6 Some Applications of Genetic Engineering
432
436
440
443
454
461
13 Genetic Control of Development
13.1 Genetic Determinants of Development
13.2 Early Embryonic Development in Animals
13.3 Genetic Analysis of Development in the Nematode
13.4 Genetic Control of Development in Drosophila
13.5 Genetic Control of Development in Higher Plants
14 Molecular Mechanisms of Mutation and DNA Repair
14.1 Types of Mutations
14.2 The Molecular Basis of Mutation
14.3 Transposable Elements
14.4 Spontaneous Mutation
14.5 Mutagens
14.6 Mechanisms of DNA Repair
14.7 Reverse Mutations and Suppressor Mutations
15 Molecular Genetics of the Cell Cycle and Cancer
15.1 The Cell Cycle
15.2 Genetic Analysis of the Cell Cycle
15.3 Progression Through the Cell Cycle
15.4 Checkpoints in the Cell Cycle
15.5 Cancer Cells
15.6 Hereditary Cancer Syndromes
15.7 Genetics of the Acute Leukemias
16 Mitochondrial DNA and Extranuclear Inheritance
16.1 Patterns of Extranuclear Inheritance
16.2 Organelle Heredity
16.3 The Evolutionary Origin of Organelles
16.4 Cytoplasmic Transmission of Symbionts
16.5 Maternal Effect in Snail Shell Coiling
471
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509
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569
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17 Molecular Evolution and Population Genetics
611
17.1 Molecular Evolution
17.2 Population Genetics
17.3 Inbreeding
17.4 Genetics and Evolution
17.5 Mutation and Migration
17.6 Natural Selection
17.7 Random Genetic Drift
17.8 Tracing Human History Through Mitochondrial DNA
612
618
627
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639
643
18 The Genetic Basis of Complex Traits
18.1 Complex Traits
18.2 Causes of Variation
18.3 Genetic Analysis of Complex Traits
18.4 Artificial Selection
18.5 Correlation Between Relatives
18.6 Heritabilities of Threshold Traits
18.7 Identification of Genes Affecting Complex Traits
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08/12/08