Agenda Item VIII
OVERVIEW OF RECERTIFICATION FOR MUSC
RESEARCH UNIVERSITY INFRASTRUCTURE PROJECT
This document is a part of the on-going development of the Research Infrastructure
Project as defined in Section 11-51-30 (4) of the South Carolina Code, to be developed primarily on
the Medical University of South Carolina campus. The background for the Charleston Translational
Research Initiative has been presented to the SC Centers of Economic Excellence Review Board
on two occasions. It was first presented on May 11, 2005, at which time MUSC was recommended
for matching funds of $36,071,822. The Board at that meeting enthusiastically endorsed the overall
concept of the Charleston Translational research Initiative.
Following that, a second presentation was done to the COEE Board on September 15,
2005. This presentation further defined the Initiative and presented additional documentation on
the buildings themselves and scope of these projects.
The current document addresses some of the changes to the Initiative that have come
as a result of several factors. First and foremost, building costs have skyrocketed such that original
project cost estimates are no longer tenable. These costs increased so much that the third phase
of the project, the Patient Oriented Research Tower (PORT), has been deferred as a RUIA-funded
project. MUSC is still engaged in developing the PORT and is working with Federal, State, and City
officials to find alternate funding to bring about this element of the Initiative.
Another significant change was the site of the Drug Discovery Building. City of
Charleston height and scale restrictions, as well as logistical problems with the original Sabin Street
site, forced MUSC to consider an alternate site. A parcel of land adjacent to the proposed
Bioengineering building site in MUSC's G Parking Lot was selected as the new site for the Drug
Discovery Building. This turned out to be a positive move as it allowed for the buildings to share
engineering and mechanical space, loading docks, lab animal space, and additional “utilities” for the
buildings.
Both the Drug Discovery and Bioengineering buildings will maintain their same
approximate size (~110,000 sq.ft.), scope, and scientific themes as presented previously. The Drug
Discovery Building will house programs for three of our Center of Excellence Endowed Chairs: Drs.
Kenneth Tew, John J. Lemasters, and Charles D. Smith. The Bioengineering building will house
interdisciplinary research from all three senior research universities. Center of Economic
Excellence chair in Regenerative Medicine, Richard Swaja, will be housed in this facility and will
continue to lead the successful Clemson-MUSC Bioengineering program within this space. A
University of South Carolina CoEE endowed chair candidate, who is under recruitment and has an
offer letter in hand, is being offered space in this building as well.
The information that follows outlines the revised program costs associated with the
Charleston Translational Research Initiative. Also summarized are the matching components that
are part of MUSC’s request for recertification of its Research University Infrastructure Act funds.
Agenda Item VIII
SUMMARY OF BUILDING AND PROGRAM EXPENSES
Charleston Phase
Drug Discovery Program
 Construction
 Site Prep
 MRE Upgrades
 10% Contingency
 Professional Services
 Plaza/Landscape
 Equipment
 After construction costs
o Furnishings
o Signage
o Security
o Audio/Visual
 3rd and 4th Floor Basic Science Building renovation
 Pharmacology -3rd and 4th floor Clinical Science Building
Hot Water upgrade
 Animal Imaging MRI facility/7T Installation
 Hollings Marine Lab
o Equipment (purchased 2003-2007)
o Construction (2003-2007)
o Facility Operations support
o Other Facility support
 GCRC Clean Room Renovation
$40,888,400
$2,112,000
$2,079,000
$4,550,000
$5,400,000
$2,800,000
$7,550,000
$1,225,000
$7,700,000
$250,000
$300,000
$2,477,527
$5,000,000
$250,000
$330,000
$210,000
TOTAL
$ 83,121,927
Bioengineering Program

Construction

Site

10% Contingency

Professional Services

Equipment

After Construction Cost (noted above)

Plaza/Landscape
$53,600,000
$11,800,000
$5,400,000
$6,400,000
$8,800,000
$1,500,000
$3,300,000
TOTAL
$79,000,000
Charleston Translational Research Initiative $162,121,927
Greenville Phase1
Translational Research program - REII Building

Interior build-out/Furniture/Fixtures
$2,519,000
TOTAL
TOTAL TRANSLATIONAL RESEARCH COST
1
See September 16, 2005, MUSC presentation to the CoEE Review Board.
$2,519,000
$164,640,927
Agenda Item VIII
SUMMARY OF MATCHING FUNDS – PREVIOUSLY DESCRIBED
1.
NMR instrumentation/construction grant
$4,201,479
awarded**
(NIST 60NANB0D0073) National Institute of Standards and Technology
08/23/2003
Description- This competitive federal infrastructure grant to the Hollings Cancer Center funded
research-related renovations and the purchase of scientific equipment for the cancer drug discovery
program. This program will be housed in the Drug Discovery Building. The state of the art
instrumentation will benefit the project directly.
2.
NMR instrumentation/construction grant
$1,000,000
awarded**
(NIST 60NANB0D0073) National Institute of Standards and Technology
08/23/2003
Description- This competitive federal infrastructure grant to the Hollings Cancer Center funded
research-related renovations and the purchase of scientific equipment for the cancer drug discovery
program. This program will be housed in the Drug Discovery Building. The state of the art
instrumentation will benefit the project directly.
3.
NMR instrumentation grant
(3 P20 RR017677-02S1) NIH National Center for Research Resources
$500,000
awarded
09/08/2003
Description- This competitive federal infrastructure grant funded the research-related purchase of
scientific equipment (NMR spectroscopy) for the drug discovery and structural biology programs.
These programs will be housed in the Drug Discovery Building. The state of the art instrumentation
will benefit the project directly.
4.
Animal imaging instruments
$2,952,479*
awarded
(HRSA 1-C76HF03130-01-00) Health Resources and Services Administration
12/23/2004
Description- This competitive federal infrastructure grant funded animal research laboratory
construction and equipment in Hollings Cancer Center supporting the cancer drug discovery
program. This program will be housed in the Drug Discovery Building. The state of the art
instrumentation will benefit the project directly.
5.
NMR instrumentation grant (accessories)
(DE-FG02-02ER63385) Department of Energy
$485,000
NMR/structural biology instrumentation
(NSF EPS-0132573) National Science Foundation
$800,000
awarded
02/03/2005
Description- This competitive federal infrastructure grant funded the research-related purchase of
scientific equipment (accessories for NMR spectroscopy) for the drug discovery and structural biology
programs. These programs will be housed in the Drug Discovery Building. The state of the art
instrumentation will benefit the project directly.
6.
awarded
06/01/2005
Description- This competitive federal infrastructure grant funded the research-related purchase of
scientific equipment (NMR spectroscopy) for the drug discovery and structural biology programs.
These programs will be housed in the Drug Discovery Building. The state of the art instrumentation
will benefit the project directly.
7.
Federal road work enhancement appropriation
$3,200,000
awarded
The Safe, Accountable, Flexible, Efficient Transportation Equity Act
08/10/2005
(SAFETEA-LU), enacted August 10, 2005. H.R.3-152, item 995
This federal infrastructure appropriation will provide funds to improve MUSC campus access,
which will make feasible construction, occupancy and operation of the Drug Discovery and
Bioengineering Buildings in the MUSC G-lot. The improved access for commuters and employees to
our core campus will benefit the project directly.
8.
Federal road work appropriation, MUSC- Charleston match $3,240,000
matched
Required match associated with SAFETEA-LU award noted above
Description - This is the local infrastructure match for #7 (SAFETEA-LU), funded by local sales tax
increase.

Award amount on ancillary documentation exceeds this amount. We represent only the amount actually devoted to this
particular infrastructure project for Life Sciences Act matching purposes.
**
South Carolina Research Infrastructure Guidelines dated August 20, 2007 allow for “…federal grants awarded prior to
march 17, 2004, this deadline [March 17, 2004] refers to the date of acquisition of an item for which the research institution
becomes eligible to receive reimbursement via federal grant dollars.” MUSC was eligible to draw down the funds from this
award as of XXX, the date of substantial completion of the project. Please refer to the attached documentation under tab 15.
Agenda Item VIII
9.
Construction grant – Bioengineering and Cancer
$9,820,650
awarded
(HRSA 1 C76HF06131-01-00) Health Resources and Services Administration
09/01/2005
Description- This competitive federal infrastructure grant will provide funds for the construction
of the Bioengineering Building. These construction funds will benefit the project directly.
10.
Federal parking appropriation
$3,887,113
awarded
(Federal Register 70/ No. 175/ Monday, September 12,2005/ 53880)
09/12/2005
Department of Transportation/Federal Transit Authority
Description- This federal infrastructure appropriation will provide funds to improve MUSC campus
parking, which will be necessary to replace XXX parking spaces lost in order to site the Drug
Discovery and Bioengineering Buildings in the MUSC G-lot. This will make feasible the construction,
occupancy and operation of the Drug Discovery and Bioengineering Buildings in the MUSC G-lot.
The parking improvements will directly benefit the project.
11.
Federal parking intermodal facility appropriation
$3,883,494
awarded
(Federal Register 70/ No. 175/ Monday, September 12,2005/ 53880)
09/12/2005
Department of Transportation/Federal Transit Authority
Description- This federal infrastructure appropriation will provide funds to improve MUSC campus
access, which will be necessary to deal with the loss of XXX parking spaces lost in order to site the
Drug Discovery and Bioengineering Buildings in the MUSC G-lot. This will make feasible the
construction, occupancy and operation of the Drug Discovery and Bioengineering Buildings in the
MUSC G-lot, directly benefiting the project.
12.
MRI equipment grant
(NSF EPS-0447660) National Institute of Standards and Technology
$1,500,000
(NSF EPS-0447660- MUSC component) National Science Foundation
awarded
09/14/2005
Description- This competitive federal infrastructure grant was funded to establish a statewide animal
imaging resource through the purchase of a 7 Tesla MRI instrument. The animal imaging program
will be housed in the Drug Discovery Building, benefiting the project directly. The state of the art
instrumentation will benefit the project directly.
13.
College of Pharmacy construction gifts
$250,000
awarded
Philanthropy- one donor
09/14/2005
Description- This gift is from CVS, for construction of facilities related to drug discovery and
Development, specifically for the CVS Pharmacy practice Laboratory, which will be housed on the
first floor of the Drug Discovery Building. These construction funds will benefit the project directly.
14.
Drug Discovery Building construction grant
$19,732,864
awarded
(NIST 60NANB5D1246) National Institute of Standards and Technology
10/01/2005
Description- This competitive federal infrastructure grant will provide funds for the construction
of the Drug Discovery Drug Discovery Building. These construction funds will benefit the project
directly.
__________
Total previous match, items 1-14:
$55,453,079
Agenda Item VIII
SUMMARY OF MATCHING FUNDS – NEW MATCHES IN HAND
15.
Animal Support Facilities and Development Grant
$2,000,000
awarded
(C06 RR015455-01A1) NIH National Center for Research Resources
02/01/2002**
Description- This competitive federal infrastructure grant to MUSC funded research-related
renovations to develop new animal care facilities that will support drug discovery, bioengineering
and cancer genomics programs to be housed in the drug Discovery and Bioengineering
Buildings. These funds allow for more laboratory space and smaller animal facilities in both
of those buildings, and thus directly benefit the project.
16.
17.
NIH/NCRR Biosafety Lab Level 3
$631,352
awarded
(1 G20 RR019721-0) NIH National Center for Research Resources
Description- This competitive federal infrastructure grant to MUSC funded research-related
renovations to develop a bio-containment level 3 facility that will enable our drug discovery
program to develop new treatments for infectious diseases, directly benefiting the project.
06/01/2004
Oral Health Research Infrastructure Development Grant $2,883,206
awarded
(NIDCR-U24 DE016508) NIH National Institute of Dental and Craniofacial Research
09/27/2004
Description- This competitive federal infrastructure grant provided funds for the enhancement
of bioengineering, materials science, regenerative medicine and other related programs in
the MUSC College of Dental Medicine, which will be housed in the Bioengineering Building.
These infrastructure funds provide a direct benefit to the project.
18.
NSF EPSCOR Equipment and Infrastructure grant
$2,302,966
(NSF EPS-0447660) National Institute of Standards and Technology
(NSF EPS-0447660- USC component) National Science Foundation
awarded
06/06/2005
Description- This competitive federal equipment and infrastructure grant was funded to
enhance the bioengineering program at USC, in collaboration with MUSC and Clemson.
These funds directly benefit the project in that this program, including USC faculty
members, students and fellows will be housed in the Bioengineering Building.
19.
NSF EPSCOR Equipment and Infrastructure grant
$1,774,000
(NSF EPS-0447660) National Institute of Standards and Technology
(NSF EPS-0447660- Clemson component) National Science Foundation
awarded
06/06/2005
Description- This competitive federal equipment and infrastructure grant was funded to
enhance the bioengineering program at Clemson, in collaboration with MUSC and USC.
These funds directly benefit the project in that this program, including USC faculty
members, students and fellows will be housed in the Bioengineering Building.
20.
Shared Instrumentation Grant
$140,205
awarded
(1 S10 RR021096-01A1) NIH National Institute of Dental and Craniofacial Research
04/01/2006
Description- This competitive federal infrastructure grant provided funds for the purchase of State of the art
instrumentation that will be enhance the drug discovery and bioengineering programs. The gene scanner and
accessories for analysis of gene expression through the use of DNA
microarray technology will benefit the project directly.
21.
Animal Support facilities and Development Grant
$529,000
awarded
(G20 RR021351) NIH National Center for Research Resources
06/01/2006
Description- This competitive federal infrastructure grant to MUSC funded research-related
renovations and equipment to develop new animal care facilities that will support drug discovery,
bioengineering and cancer genomics programs to be housed in the drug Discovery and
Bioengineering Buildings. These funds allow for more laboratory space and smaller animal facilities in
both of those buildings, and thus directly benefit the project.
**
South Carolina Research Infrastructure Guidelines dated August 20, 2007 allow for “…federal grants awarded prior to march 17,
2004, this deadline [March 17, 2004] refers to the date of acquisition of an item for which the research institution becomes eligible
to receive reimbursement via federal grant dollars.” MUSC was eligible to draw down the funds from this award as of XXX, the date
of substantial completion of the project. Please refer to the attached documentation under tab 15.
Agenda Item VIII
22.
Construction grant - Center for Bioengineering
and Cancer Genomics
$7,897,824
awarded
08/22/2006
(NIST 60NANB6D6150) National Institute of Standards and Technology
Description- This competitive federal infrastructure grant will provide funds for the construction
of the Bioengineering Building. These construction funds will benefit the project directly.
23.
UMA
Department of Pharmacology, MUSC
$3,700,000
Stem Cell/Regenerative Medicine Core Facility
$187,792***
(P20 RR016461) NIH National Institute of Dental and Craniofacial Research
24.
in process
(Renovations of Drug Discovery laboratory space in the Basic Science Building)
under construction
Description- These renovations were proposed in our original proposal to be funded by a competitive
federal C06 infrastructure construction grant, for which an outstanding score was received. Congress
de-funded the C06 program of the National Center for Research Resources of the NIH, so we
pursued alternative sources of funding for these critical renovations of Department of Pharmacology
drug discovery program space. Fortunately the University Medical Associates has funded this project
from non-state revenues generated by the physician practice. These renovations directly benefit the
project as was described in our original presentation.
awarded
09/30/2005
Description- This competitive federal infrastructure grant provided funds for equipment to develop a statewide
bioengineering core facility. This award directly benefits the project in that this program will be housed in the
Bioengineering Building.
25.
Greenville Hospital System REII
Qui ckTim e™ an d a
TIFF (Uncompressed ) deco mpre ssor
are need ed to s ee thi s pictu re.
26. UMA
$12,446,382
in process
under construction
Description-Partnership between MUSC and Greenville Hospital System (GHS). Construction, upfit and 20 year
lease of 16,050 sqft of Translational research and simulation floor within the Research and Education Innovation
Center (REII).
Animal Imaging MRI facility/7T Installation
$300,000 constructed
Description- These costs are directly aligned with match item number #12 noted above. University Medical
Associates covered the costs for required space renovations to accommodate 7 Tesla MRI instrument. This
space will temporarily house this equipment until the animal imaging program
can be housed in the Drug Discovery Building, benefiting the project directly.
27. UMA
Pharmacology -3rd and 4th floor Clinical Science Building
Hot Water upgrade
$250,000
GCRC Clean Room Renovation
$210,000
in process
under construction
Description-Staging and Temporary space for Dept of Pharmacology while their space in BSB is renovated.
Needed Hot Water upgrade for laboratory functionality.
28. UMA
Description-Renovation of Clean Room for General Clinical Research
Facility.
29.
Hollings Marine Laboratory
in process
under construction
$ 8,507,527 constructed
Description-Structual Biology program at Hollings Marine lab occupies ~3,000 sq.ft
of office and laboratory space including specialized NMR instrument rooms and operating
areas.
30.
Translational Research program
REII Building-Greenville
$8,625,717
in process
under construction
Description-Calculated rent value of 16,050 usf of space over 20-year lease period. Partnership between MUSC
and Greenville Hospital System (GHS).
Total new match, items 15-30:
***
$ 52,385,971
Award amount on ancillary documentation exceeds this amount. We represent only the amount actually devoted to this
particular infrastructure project for Life Sciences Act matching purposes.
Agenda Item VIII
PROJECT COST, MATCH AND FUNDING SUMMARY
Total Project Cost
$164,640,927
Total RUIA match eligible (items 1-30 above):
$107,839,050
Total General Obligation Debt Requested
$77,322,6922
“Overmatch” from MUSC
$25,518,5863
This total includes $2 million of USC’s share of RUIA bonds and $1.989359 million of Clemson’s share of RUIA bonds.
3 Calculated by dividing the total cost of the project in half, then subtracting the result from the overall match total.
2