BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors.
Follow this format for each person. DO NOT EXCEED TWO PAGES.
NAME
POSITION TITLE
Jarvik, Jeffrey G.
Professor of Radiology and Neurosurgery; Adjunct
Professor Health Services
eRA COMMONS USER NAME (credential, e.g., agency login)
jarvikj
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and
residency training if applicable.)
DEGREE
INSTITUTION AND LOCATION
MM/YY
FIELD OF STUDY
(if applicable)
University of California, San Diego
University of California, San Diego
Hospital of the University of Pennsylvania
Hospital of the University of Pennsylvania
University of Washington
BA
MD
Residency
Fellowship
MPH
12/81
06/87
06/92
06/93
1995
Biochem and Cell Biol
Medicine
Diagnostic Radiology
Neuroradiology
Health Services
A. Personal Statement
As the Director of the Comparative Effectiveness, Cost and Outcomes Research Center at the
University of Washington, I have led or collaborated on multiple technology assessments using
multidisciplinary teams involving a wide variety of medical and surgical specialties and non-clinical disciplines
of biostatistics, economics, epidemiology, and health services. But equally importantly, I have training in health
services research and study design. After finishing my residency in Radiology and fellowship in Neuroradiology
at the University of Pennsylvania, I became a Robert Wood Johnson Clinical Scholar at the University of
Washington, where I earned my Masters in Public Health. My studies in the Clinical Scholars Program focused
on the evaluation of diagnostic and therapeutic technologies related to low back pain, with Richard A. Deyo,
MD MPH as my primary mentor.
I have extensive practical experience in the conduct of randomized controlled trials of devices and
procedures. I designed my first randomized trial, the Seattle Lumbar Imaging Project (SLIP), comparing a rapid
MR to plain films as the initial imaging for primary care patients with low back pain. I successfully obtained a
highly competitive career development award called the GE-Association of University Radiologists (AUR)
Radiology Research Fellowship (GERRAF) that allowed me to apply for an R01 from AHCPR (the predecessor
to AHRQ) to fund SLIP. The completed study was published in JAMA. Continuing my work with Dr. Deyo, I
became the Associate Director of the Multidisciplinary Clinical Research Center (MCRC) for Upper Extremity
and Spinal Disorders funded by NIAMS/NIH. I was the PI of a randomized trial comparing surgical to nonsurgical treatment for carpal tunnel syndrome which was recently published in The Lancet. During this time, I
also collaborated with David Kallmes, MD to investigate the effectiveness of vertebroplasty for osteoporotic
fractures. This collaboration led to a recent New England Journal of Medicine publication, which is proving to
have a major impact on the practice of vertebral augmentation. Our group also published a manuscript in
JAMA examining surgical trends for spinal stenosis in the elderly, demonstrating that more expensive and
complex surgery is being done without any discernable patient benefit.
B. Positions and Honors
Positions and Employment
1987-1988
Medical Internship, Mercy Hospital and Medical Center, San Diego, CA
1988-1992
Medical Residency, Radiology, Hospital of the University of Pennsylvania
1988-1993
Assistant Instructor, Radiology, Hospital of the University of Pennsylvania
1991-1993
Fellow in Neuroradiology, Radiology, Hospital of the University of Pennsylvania
1993-1995
Acting Instructor, Radiology, University of Washington
1995-2000
Assistant Professor, Radiology, University of Washington
1999-2000
Adjunct Assistant Professor, Dept. of Health Services, University of Washington
2000-2004
Associate Professor, Dept. of Radiology, Dept. of Neurological Surgery and Adjunct Health
Services, University of Washington
2004Professor, Departments of Radiology and Neurological Surgery and Adjunct Health
Services, University of Washington
2004-2008
Honors
1981
1981
Section Chief, Neuroradiology, Department of Radiology, University of Washington
Phi Beta Kappa: University of California, San Diego
Magna Cum Laude: BA, University of California, San Diego
C. Selected Peer-reviewed Publications (Selected from 72 peer-reviewed publications)
Most relevant to the current application
1. Jarvik JG. Practical issues in conducting clinical trials: randomized, controlled trials of imaging studies.
Academic Radiology 5(suppl 2):S266-S268, 1998.
2. Jarvik JG, Hollingworth W, Martin BI, Emerson SS, Gray DT, Overman, S, Robinson D, Staiger T,
Wessbecher F, Sullivan SD, Kreuter W, Deyo RA. The Seattle Lumbar Imaging Project:A Randomized
Controlled Trial of Rapid MR vs Radiographs for Patients with Low Back Pain.JAMA;289(21):2810-18,2003
3. Hollingworth W, Jarvik JG. Technology Assessment in Radiology: Putting the Evidence in Evidence-based
Radiology. Radiology. Jul;244(1):31-38, 2007.
4. Nathan RO, Blackmore CC, Jarvik JG. Therapeutic impact of CT of the appendix in a community hospital
emergency department. American Journal of Roentgenology Oct; 191(4):1102-1106, 2008.
5. Kallmes DF, Comstock BA, Heagerty PJ, Turner JA, Wilson, DJ, Diamond TH, Edwards R, Gray LA, Stout
L, Owen S, Hollingworth W, Ghdoke B, Annesley-Williams DJ, Langston A, Ralston SH, Jarvik JG. A
Randomized Controlled Trial of Vertebroplasty for Osteoporotic Spine Fractures. New Engl J Med Aug; 361
(6): 569-579, 2009.
6. Jarvik JG, Comstock BA, Kliot M, Turner JA, Chan L, Heagerty PJ, Hollingworth W, Kerrigan CL, Deyo RA.
Surgery versus non-surgical therapy for carpal tunnel syndrome: a randomised parallel-group trial. Lancet;
374: 1074-1081, 2009.
7. Deyo RA, Mirza SK, Martin BI, Kreuter W, Goodman DC, Jarvik JG. Trends, Major Medical Complications,
and Charges Associated with Surgery for Lumbar Spinal Stenosis in Older Adults. JAMA Apr;
303(13):1259-1265, 2010.
D. Research Support
Ongoing Research Support
R01 HS019222-01
Jarvik (PI)
9/30/10-9/29/13 AHRQ
Back pain Outcomes using Longitudinal Data (BOLD)
The broad, long-term goal of this project is to build a research infrastructure to study low back pain in the
elderly using the HMO Research Network. The specific goals are threefold: 1) construct the BOLD registry
of elderly patients with low back pain; 2) perform a randomized controlled trial of epidural steroid
injections vs. local anesthetic injections for elderly patients with spinal stenosis; 3) perform an
observational cohort study of early imaging in elderly patients with low back pain
Role: Overall PI
R01 1AR054912-01A2 Jarvik (PI)
9/16/08 – 7/31/11 Oregon Health & Science University
Complications of Surgery for Spinal Stenosis: A Clinical Prediction Rule
The major goal of this study is to improve patient safety in surgery for spinal stenosis by enhancing
surgeons’ ability to estimate operative risks and advise patients about the benefits and risks of spine
surgery, thus improving patient safety in a high-risk context.
Role: PI of Subcontract
R01 AR054912
Jarvik (PI)
9/01/09—8/31/11 Oregon Health and Science University
Complications of Surgery for Spinal Stenosis: A Clinical Prediction Rule (Supplement)
The goal of this supplement is to accelerate our work on spinal stenosis prediction rules. We will examine the
probability of reoperation following fusion surgery and the probability of major complications following surgery.
Role: PI of Subcontract
Completed Research Support Within Past 3 Years
R01 AR049373-06
Kallmes (PI) Mayo Clinic
9/30/02 – 12/30/09 NIAMS
Title: A Controlled Trial of Percutaneous Vertebroplasty.
This study is a randomized controlled trial of vertebroplasty vs. a local anesthetic control injection. Dr. Jarvik is
PI of the UW subcontract housing the Data Coordinating Center.
Role: PI of UW Subcontract for Data Coordinating Center