2005 年 1. Yu, M., et al., Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain. Mol Biol Cell, 2007. 18(2): p. 688-96. 2. Yoshida, H., ER stress and diseases. Febs J, 2007. 274(3): p. 630-58. 3. Yokozeki, T., et al., Meltrin beta (ADAM19) mediates ectodomain shedding of Neuregulin beta1 in the Golgi apparatus: fluorescence correlation spectroscopic observation of the dynamics of ectodomain shedding in living cells. Genes Cells, 2007. 12(3): p. 329-43. 4. Yamasaki, S., et al., Zinc is a novel intracellular second messenger. J Cell Biol, 2007. 177(4): p. 637-45. 5. Yagi, R., et al., C-terminal Src kinase controls development and maintenance of mouse squamous epithelia. Embo J, 2007. 26(5): p. 1234-44. 6. Watanabe, M., T. Tsukiyama, and S. Hatakeyama, Protection of vincristine-induced neuropathy by WldS expression and the independence of the activity of Nmnat1. Neurosci Lett, 2007. 411(3): p. 228-32. 7. Umemura, K., et al., Neuroprotective role of transgenic PAF-acetylhydrolase II in mouse models of focal cerebral ischemia. Stroke, 2007. 38(3): p. 1063-8. 8. Uchida, T., et al., Protein kinase Cdelta plays a non-redundant role in insulin secretion in pancreatic beta cells. J Biol Chem, 2007. 282(4): p. 2707-16. 9. Tsuboi, T., E. Kanno, and M. Fukuda, The polybasic sequence in the C2B domain of rabphilin is required for the vesicle docking step in PC12 cells. J Neurochem, 2007. 100(3): p. 770-9. 10. Tsuboi, T. and M. Fukuda, Synaptotagmin VII modulates the kinetics of dense-core vesicle exocytosis in PC12 cells. Genes Cells, 2007. 12(4): p. 511-9. 11. Tamura, K., et al., Arabidopsis KAM2/GRV2 is required for proper endosome formation and functions in vacuolar sorting and determination of the embryo growth axis. Plant Cell, 2007. 19(1): p. 320-32. 12. Shiraishi, S., et al., TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation. J Biol Chem, 2007. 282(12): p. 9017-28. 13. Savaskan, N.E., et al., Autotaxin (NPP-2) in the brain: cell type-specific expression and regulation during development and after neurotrauma. Cell Mol Life Sci, 2007. 64(2): p. 230-43. 14. Sato, Y., N. Miyasaka, and Y. Yoshihara, Hierarchical regulation of odorant receptor gene choice and subsequent axonal projection of olfactory sensory neurons in zebrafish. J Neurosci, 2007. 27(7): p. 1606-15. 15. Sano, H., et al., Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane. Cell Metab, 2007. 5(4): p. 293-303. 16. Sakane, A., S. Hatakeyama, and T. Sasaki, Involvement of Rabring7 in EGF receptor degradation as an E3 ligase. Biochem Biophys Res Commun, 2007. 357(4): p. 1058-64. 17. Oikawa, D., Y. Kimata, and K. Kohno, Self-association and BiP dissociation are not sufficient for activation of the ER stress sensor Ire1. J Cell Sci, 2007. 120(Pt 9): p. 1681-8. 18. Ohuchi, H., et al., Diversified expression patterns of autotaxin, a gene for phospholipid-generating enzyme during mouse and chicken development. Dev Dyn, 2007. 236(4): p. 1134-43. 19. Ohgimoto, K., et al., Difference in production of infectious wild-type measles and vaccine viruses in monocyte-derived dendritic cells. Virus Res, 2007. 123(1): p. 1-8. 20. Ohara-Imaizumi, M., et al., Imaging analysis reveals mechanistic differences between first- and second-phase insulin exocytosis. J Cell Biol, 2007. 177(4): p. 695-705. 21. Nakamura, K., et al., Measurement of lysophospholipase D/autotaxin activity in human serum samples. Clin Biochem, 2007. 40(3-4): p. 274-7. 22. Nakajima, A., et al., Ligand-dependent transcription of estrogen receptor alpha is mediated by the ubiquitin ligase EFP. Biochem Biophys Res Commun, 2007. 357(1): p. 245-51. 23. Nakai, A., et al., The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med, 2007. 13(5): p. 619-24. 24. Nakagawa, T., Y. Nabeshima, and S. Yoshida, Functional identification of the actual and potential stem cell compartments in mouse spermatogenesis. Dev Cell, 2007. 12(2): p. 195-206. 25. Mitsui, S., et al., A transcriptional enhancer that directs telencephalon-specific transgene expression in mouse brain. Cereb Cortex, 2007. 17(3): p. 522-30. 26. Matsumura, T., et al., Human milk SIgA binds to botulinum type B 16S toxin and limits toxin adherence on T84 cells. Biochem Biophys Res Commun, 2007. 352(4): p. 867-72. 27. Matsuki, Y., et al., Novel regulation of MHC class II function in B cells. Embo J, 2007. 26(3): p. 846-54. 28. Matsuda, M., et al., Establishment of a newly improved detection system for NF-kappaB activity. Immunol Lett, 2007. 109(2): p. 175-81. 29. Kyuuma, M., et al., AMSH, an ESCRT-III associated enzyme, deubiquitinates cargo on MVB/late endosomes. Cell Struct Funct, 2007. 31(2): p. 159-72. 30. Kurotaki, Y., et al., Blastocyst axis is specified independently of early cell lineage but aligns with the ZP shape. Science, 2007. 316(5825): p. 719-23. 31. Konstantinova, I., et al., EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets. Cell, 2007. 129(2): p. 359-70. 32. Kondo, S., et al., BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer. Mol Cell Biol, 2007. 27(5): p. 1716-29. 33. Komatsu, M., et al., Constitutive autophagy: vital role in clearance of unfavorable proteins in neurons. Cell Death Differ, 2007. 14(5): p. 887-94. 34. Kohda, K., et al., The extreme C-terminus of GluRdelta2 is essential for induction of long-term depression in cerebellar slices. Eur J Neurosci, 2007. 25(5): p. 1357-62. 35. Kishida, S., et al., Dvl regulates endo- and exocytotic processes through binding to synaptotagmin. Genes Cells, 2007. 12(1): p. 49-61. 36. Kato, T., et al., Virulence of Porphyromonas gingivalis is altered by substitution of fimbria gene with different genotype. Cell Microbiol, 2007. 9(3): p. 753-65. 37. Kang, S.H., et al., Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2. J Biol Chem, 2007. 282(8): p. 5256-62. 38. Iwashita, S., et al., Versatile roles of R-Ras GAP in neurite formation of PC12 cells and embryonic vascular development. J Biol Chem, 2007. 282(6): p. 3413-7. 39. Isono, E., et al., The assembly pathway of the 19S regulatory particle of the yeast 26S proteasome. Mol Biol Cell, 2007. 18(2): p. 569-80. 40. Hoshino, T., et al., Endoplasmic reticulum chaperones inhibit the production of amyloid-beta peptides. Biochem J, 2007. 402(3): p. 581-9. 41. Hosaka, M., et al., A subset of p23 localized on secretory granules in pancreatic beta-cells. J Histochem Cytochem, 2007. 55(3): p. 235-45. 42. Hashii, M., et al., Up-regulation of ras-GAP genes is reversed by a MEK inhibitor and doxorubicin in v-Ki-ras-transformed NIH/3T3 fibroblasts. Biochem Biophys Res Commun, 2007. 356(2): p. 374-80. 43. Haberman, Y., et al., Synaptotagmin (Syt) IX is an essential determinant for protein sorting to secretory granules in mast cells. Blood, 2007. 109(8): p. 3385-92. 44. Furuta, K., et al., Activation of histidine decarboxylase through post-translational cleavage by caspase-9 in a mouse mastocytoma P-815. J Biol Chem, 2007. 282(18): p. 13438-46. 45. Fujimoto-Ouchi, K., et al., Capecitabine improves cancer cachexia and normalizes IL-6 and PTHrP levels in mouse cancer cachexia models. Cancer Chemother Pharmacol, 2007. 59(6): p. 807-15. 46. Fuji, K., et al., Arabidopsis vacuolar sorting mutants (green fluorescent seed) can be identified efficiently by secretion of vacuole-targeted green fluorescent protein in their seeds. Plant Cell, 2007. 19(2): p. 597-609. 47. Davila-Perez, C., et al., Distribution of genotypes of Porphyromonas gingivalis in type 2 diabetic patients with periodontitis in Mexico. J Clin Periodontol, 2007. 34(1): p. 25-30. 48. Araki, Y., et al., The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport. Embo J, 2007. 26(6): p. 1475-86. 49. Aoki, J., et al., Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family. Biochimie, 2007. 89(2): p. 197-204. 50. Akimoto, Y., et al., Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic Goto-Kakizaki rats. Glycobiology, 2007. 17(2): p. 127-40. 2006 年 51. Zhang, J., et al., Involvement of COX-1 and up-regulated prostaglandin E synthases in phosphatidylserine liposome-induced prostaglandin E2 production by microglia. J Neuroimmunol, 2006. 172(1-2): p. 112-20. 52. Yoshida, M., et al., IgG transport across mucosal barriers by neonatal Fc receptor for IgG and mucosal immunity. Springer Semin Immunopathol, 2006. 28(4): p. 397-403. 53. Yoshida, M., et al., Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. J Clin Invest, 2006. 116(8): p. 2142-2151. 54. Yonashiro, R., et al., A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics. Embo J, 2006. 25(15): p. 3618-26. 55. Yogosawa, S., et al., Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability. Biochem Biophys Res Commun, 2006. 350(1): p. 82-90. 56. Yamashita, S., et al., PI4P-signaling pathway for the synthesis of a nascent membrane structure in selective autophagy. J Cell Biol, 2006. 173(5): p. 709-17. 57. Yamasaki, S., et al., Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development. Nat Immunol, 2006. 7(1): p. 67-75. 58. Yamasaki, A., et al., The Ca2+-binding protein ALG-2 is recruited to endoplasmic reticulum exit sites by Sec31A and stabilizes the localization of Sec31A. Mol Biol Cell, 2006. 17(11): p. 4876-87. 59. Yamada, S., et al., Uncoupling protein 2 negatively regulates neurite extensions in PC12h cells. Neurosci Lett, 2006. 410(2): p. 110-4. 60. Yahara, N., K. Sato, and A. Nakano, The Arf1p GTPase-activating protein Glo3p executes its regulatory function through a conserved repeat motif at its C-terminus. J Cell Sci, 2006. 119(Pt 12): p. 2604-12. 61. Watanabe, N., et al., Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells. Am J Pathol, 2006. 168(5): p. 1737-48. 62. Wang, Q.J., et al., Induction of autophagy in axonal dystrophy and degeneration. J Neurosci, 2006. 26(31): p. 8057-68. 63. Waguri, S., et al., The luminal domain participates in the endosomal trafficking of the cation-independent mannose 6-phosphate receptor. Exp Cell Res, 2006. 312(20): p. 4090-107. 64. van der Klei, I.J., et al., The significance of peroxisomes in methanol metabolism in methylotrophic yeast. Biochim Biophys Acta, 2006. 1763(12): p. 1453-62. 65. Uehara, S., et al., Vesicular storage and secretion of L-glutamate from glucagon-like peptide 1-secreting clonal intestinal L cells. J Neurochem, 2006. 96(2): p. 550-60. 66. Tsuda, S., et al., Cyclic phosphatidic acid is produced by autotaxin in blood. J Biol Chem, 2006. 281(36): p. 26081-8. 67. Tsuboi, T. and M. Fukuda, Rab3A and Rab27A cooperatively regulate the docking step of dense-core vesicle exocytosis in PC12 cells. J Cell Sci, 2006. 119(Pt 11): p. 2196-203. 68. Tsuboi, T. and M. Fukuda, The Slp4-a linker domain controls exocytosis through interaction with Munc18-1.syntaxin-1a complex. Mol Biol Cell, 2006. 17(5): p. 2101-12. 69. Toyama, R., et al., Impaired regulation of gonadotropins leads to the atrophy of the female reproductive system in klotho-deficient mice. Endocrinology, 2006. 147(1): p. 120-9. 70. Torashima, T., et al., Exposure of lentiviral vectors to subneutral pH shifts the tropism from Purkinje cell to Bergmann glia. Eur J Neurosci, 2006. 24(2): p. 371-80. 71. Terai, T., et al., JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin. Mol Biol Cell, 2006. 17(5): p. 2465-75. 72. Tanaka, M., et al., Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid. J Biol Chem, 2006. 281(35): p. 25822-30. 73. Tanaka, M., et al., Single-point mutations of hepatitis C virus NS3 that impair p53 interaction and anti-apoptotic activity of NS3. Biochem Biophys Res Commun, 2006. 340(3): p. 792-9. 74. Tanaka, K.J., et al., RAP55, a cytoplasmic mRNP component, represses translation in Xenopus oocytes. J Biol Chem, 2006. 281(52): p. 40096-106. 75. Takeuchi, M., Y. Kimata, and K. Kohno, Causal links between protein folding in the ER and events along the secretory pathway. Autophagy, 2006. 2(4): p. 323-4. 76. Takeuchi, M., et al., Saccharomyces cerevisiae Rot1p is an ER-localized membrane protein that may function with BiP/Kar2p in protein folding. J Biochem (Tokyo), 2006. 139(3): p. 597-605. 77. Takenawa, T. and T. Itoh, Membrane targeting and remodeling through phosphoinositide-binding domains. IUBMB Life, 2006. 58(5-6): p. 296-303. 78. Takemura, A., et al., Inhibitory effects of tumor necrosis factor-alpha on migration of human periodontal ligament cells. J Periodontol, 2006. 77(5): p. 883-90. 79. Takeda, M., et al., Relationship of serum advanced glycation end products with deterioration of periodontitis in type 2 diabetes patients. J Periodontol, 2006. 77(1): p. 15-20. 80. Takatsu, H., et al., CD300 antigen like family member G: A novel Ig receptor like protein exclusively expressed on capillary endothelium. Biochem Biophys Res Commun, 2006. 348(1): p. 183-91. 81. Takamori, S., et al., Molecular anatomy of a trafficking organelle. Cell, 2006. 127(4): p. 831-46. 82. Suzuki, T., et al., Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis. J Biochem (Tokyo), 2006. 139(6): p. 949-55. 83. Sun-Wada, G.H., et al., The a3 isoform of V-ATPase regulates insulin secretion from pancreatic beta-cells. J Cell Sci, 2006. 119(Pt 21): p. 4531-40. 84. Sohara, E., et al., Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation. Proc Natl Acad Sci U S A, 2006. 103(38): p. 14217-22. 85. Shimada, T., et al., AtVPS29, a putative component of a retromer complex, is required for the efficient sorting of seed storage proteins. Plant Cell Physiol, 2006. 47(9): p. 1187-94. 86. Shiba, T., et al., Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1. Proc Natl Acad Sci U S A, 2006. 103(42): p. 15416-21. 87. Saxena, S.K., H. Horiuchi, and M. Fukuda, Rab27a regulates epithelial sodium channel (ENaC) activity through synaptotagmin-like protein (SLP-5) and Munc13-4 effector mechanism. Biochem Biophys Res Commun, 2006. 344(2): p. 651-7. 88. Satoh, T., et al., Structures of the carbohydrate recognition domain of Ca2+-independent cargo receptors Emp46p and Emp47p. J Biol Chem, 2006. 281(15): p. 10410-9. 89. Sasakawa, H., et al., Solution structure and dynamics of Ufm1, a ubiquitin-fold modifier 1. Biochem Biophys Res Commun, 2006. 343(1): p. 21-6. 90. Sano, Y., et al., Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the X11L-deficient mouse brain. J Biol Chem, 2006. 281(49): p. 37853-60. 91. Sano, Y., et al., Physiological Mouse Brain Abeta Levels Are Not Related to the Phosphorylation State of Threonine-668 of Alzheimer's APP. PLoS ONE, 2006. 1: p. e51. 92. Sakane, A., et al., Rab3 GTPase-activating protein regulates synaptic transmission and plasticity through the inactivation of Rab3. Proc Natl Acad Sci U S A, 2006. 103(26): p. 10029-34. 93. Sakai, Y., et al., Pexophagy: autophagic degradation of peroxisomes. Biochim Biophys Acta, 2006. 1763(12): p. 1767-75. 94. Saegusa, C., et al., Decreased basal mucus secretion by Slp2-a-deficient gastric surface mucous cells. Genes Cells, 2006. 11(6): p. 623-31. 95. Rajendran, L., et al., Alzheimer's disease beta-amyloid peptides are released in association with exosomes. Proc Natl Acad Sci U S A, 2006. 103(30): p. 11172-7. 96. Qian, L., et al., Phosphorothioate analogues of alkyl lysophosphatidic acid as LPA3 receptor-selective agonists. ChemMedChem, 2006. 1(3): p. 376-83. 97. Omote, H., et al., The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations. Trends Pharmacol Sci, 2006. 27(11): p. 587-93. 98. Okuda, J., et al., Intracellular replication of Edwardsiella tarda in murine macrophage is dependent on the type III secretion system and induces an up-regulation of anti-apoptotic NF-kappaB target genes protecting the macrophage from staurosporine-induced apoptosis. Microb Pathog, 2006. 41(6): p. 226-40. 99. Oku, M., et al., Role of Vac8 in formation of the vacuolar sequestering membrane during micropexophagy. Autophagy, 2006. 2(4): p. 272-9. 100. Okazaki, H., et al., Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: a potential role in adipocyte lipolysis. Diabetes, 2006. 55(7): p. 2091-7. 101. Okada, M., et al., Kinetics and strain variation of phagosome proteins of Entamoeba histolytica by proteomic analysis. Mol Biochem Parasitol, 2006. 145(2): p. 171-83. 102. Oka, Y., et al., Odorant receptor map in the mouse olfactory bulb: in vivo sensitivity and specificity of receptor-defined glomeruli. Neuron, 2006. 52(5): p. 857-69. 103. Ohtsuki, M., et al., Transgenic expression of group V, but not group X, secreted phospholipase A2 in mice leads to neonatal lethality because of lung dysfunction. J Biol Chem, 2006. 281(47): p. 36420-33. 104. Ohsaki, Y., et al., Recruitment of TIP47 to lipid droplets is controlled by the putative hydrophobic cleft. Biochem Biophys Res Commun, 2006. 347(1): p. 279-87. 105. Ohsaki, Y., et al., Cytoplasmic lipid droplets are sites of convergence of proteasomal and autophagic degradation of apolipoprotein B. Mol Biol Cell, 2006. 17(6): p. 2674-83. 106. Ohno, T., et al., Proinflammatory gene expression in mouse ST2 cell line in response to infection by Porphyromonas gingivalis. Microbes Infect, 2006. 8(4): p. 1025-34. 107. Ohno, N., et al., Expression of protein 4.1G in Schwann cells of the peripheral nervous system. J Neurosci Res, 2006. 84(3): p. 568-77. 108. Ohmura-Hoshino, M., et al., Inhibition of MHC class II expression and immune responses by c-MIR. J Immunol, 2006. 177(1): p. 341-54. 109. Ohmura-Hoshino, M., et al., A novel family of membrane-bound E3 ubiquitin ligases. J Biochem (Tokyo), 2006. 140(2): p. 147-54. 110. Ohara-Imaizumi, M. and S. Nagamatsu, Insulin exocytotic mechanism by imaging technique. J Biochem (Tokyo), 2006. 140(1): p. 1-5. 111. Ogata, M., et al., Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol, 2006. 26(24): p. 9220-31. 112. Numata, T., et al., Structural basis for sulfur relay to RNA mediated by heterohexameric TusBCD complex. Structure, 2006. 14(2): p. 357-66. 113. Nozaki, T. and K. Nakada-Tsukui, Membrane trafficking as a virulence mechanism of the enteric protozoan parasite Entamoeba histolytica. Parasitol Res, 2006. 98(3): p. 179-83. 114. Nomura-Takigawa, Y., et al., Non-structural protein 4A of Hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis. J Gen Virol, 2006. 87(Pt 7): p. 1935-45. 115. Nomura, R., et al., Isolation and characterization of Streptococcus mutans in heart valve and dental plaque specimens from a patient with infective endocarditis. J Med Microbiol, 2006. 55(Pt 8): p. 1135-40. 116. Nishimura, Y., et al., Active digestion of sperm mitochondrial DNA in single living sperm revealed by optical tweezers. Proc Natl Acad Sci U S A, 2006. 103(5): p. 1382-7. 117. Nakaya, T. and T. Suzuki, Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD. Genes Cells, 2006. 11(6): p. 633-45. 118. Nakano, K., et al., Detection of cariogenic Streptococcus mutans in extirpated heart valve and atheromatous plaque specimens. J Clin Microbiol, 2006. 44(9): p. 3313-7. 119. Nakanishi-Matsui, M., et al., Stochastic high-speed rotation of Escherichia coli ATP synthase F1 sector: the epsilon subunit-sensitive rotation. J Biol Chem, 2006. 281(7): p. 4126-31. 120. Nakamura, M., et al., Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes. Genes Cells, 2006. 11(6): p. 593-606. 121. Nakagawa, I., et al., Invasion of epithelial cells and proteolysis of cellular focal adhesion components by distinct types of Porphyromonas gingivalis fimbriae. Infect Immun, 2006. 74(7): p. 3773-82. 122. Nagamatsu, S., et al., Imaging docking and fusion of insulin granules induced by antidiabetes agents: sulfonylurea and glinide drugs preferentially mediate the fusion of newcomer, but not previously docked, insulin granules. Diabetes, 2006. 55(10): p. 2819-25. 123. Nabeshima, Y., Toward a better understanding of Klotho. Sci Aging Knowledge Environ, 2006. 2006(8): p. pe11. 124. Morita, M.T., et al., A C2H2-type zinc finger protein, SGR5, is involved in early events of gravitropism in Arabidopsis inflorescence stems. Plant J, 2006. 47(4): p. 619-28. 125. Morimoto, R., et al., Secretion of L-glutamate from osteoclasts through transcytosis. Embo J, 2006. 25(18): p. 4175-86. 126. Mori, T., et al., GENERATIVE CELL SPECIFIC 1 is essential for angiosperm fertilization. Nat Cell Biol, 2006. 8(1): p. 64-71. 127. Mizuno, E., et al., A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes. Traffic, 2006. 7(8): p. 1017-31. 128. Miyake, A., et al., Cloning and pattern of expression of the shiro-uo vasa gene during embryogenesis and its roles in PGC development. Int J Dev Biol, 2006. 50(7): p. 619-25. 129. Miura, E., et al., Distinct expression of Cbln family mRNAs in developing and adult mouse brains. Eur J Neurosci, 2006. 24(3): p. 750-60. 130. Miletic, A.V., et al., Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation. J Biol Chem, 2006. 281(50): p. 38257-65. 131. Matsuura-Tokita, K., et al., Live imaging of yeast Golgi cisternal maturation. Nature, 2006. 441(7096): p. 1007-10. 132. Matsuura, R., et al., Crucial transcription factors in endoderm and embryonic gut development are expressed in gut-like structures from mouse ES cells. Stem Cells, 2006. 24(3): p. 624-30. 133. Matsui, M., et al., Organelle degradation during the lens and erythroid differentiation is independent of autophagy. Biochem Biophys Res Commun, 2006. 339(2): p. 485-9. 134. Matsuda, S., K. Matsuda, and M. Yuzaki, A new motif necessary and sufficient for stable localization of the delta2 glutamate receptors at postsynaptic spines. J Biol Chem, 2006. 281(25): p. 17501-9. 135. Matsuda, K., et al., Characterization of the delta2 glutamate receptor-binding protein delphilin: Splicing variants with differential palmitoylation and an additional PDZ domain. J Biol Chem, 2006. 281(35): p. 25577-87. 136. Masuda, Y., et al., ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells. J Lipid Res, 2006. 47(1): p. 87-98. 137. Masahira, N., et al., Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells. Dev Biol, 2006. 293(2): p. 358-69. 138. Makino, Y., et al., Elmo1 inhibits ubiquitylation of Dock180. J Cell Sci, 2006. 119(Pt 5): p. 923-32. 139. Mahoney, T.R., et al., Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans. Mol Biol Cell, 2006. 17(6): p. 2617-25. 140. Maeshima, K., et al., Cell-cycle-dependent dynamics of nuclear pores: pore-free islands and lamins. J Cell Sci, 2006. 119(Pt 21): p. 4442-51. 141. Luo, H., et al., Visualization of the post-Golgi trafficking of multiphoton photoactivated transferrin receptors. Cell Struct Funct, 2006. 31(2): p. 63-75. 142. Li, L., et al., MAIGO2 is involved in exit of seed storage proteins from the endoplasmic reticulum in Arabidopsis thaliana. Plant Cell, 2006. 18(12): p. 3535-47. 143. Kumanomidou, T., et al., The crystal structure of human Atg4b, a processing and de-conjugating enzyme for autophagosome-forming modifiers. J Mol Biol, 2006. 355(4): p. 612-8. 144. Kondo, H., et al., Constitutive GDP/GTP exchange and secretion-dependent GTP hydrolysis activity for Rab27 in platelets. J Biol Chem, 2006. 281(39): p. 28657-65. 145. Komatsu, M., et al., Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature, 2006. 441(7095): p. 880-4. 146. Komatsu, M., E. Kominami, and K. Tanaka, Autophagy and neurodegeneration. Autophagy, 2006. 2(4): p. 315-7. 147. Kogo, H., et al., Differential expression of caveolin-3 in mouse smooth muscle cells in vivo. Cell Tissue Res, 2006. 324(2): p. 291-300. 148. Kishi, Y., et al., Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid. J Biol Chem, 2006. 281(25): p. 17492-500. 149. Kimata, Y., et al., Yeast unfolded protein response pathway regulates expression of genes for anti-oxidative stress and for cell surface proteins. Genes Cells, 2006. 11(1): p. 59-69. 150. Kim, B.Y., et al., The interaction of mammalian Class C Vps with nSec-1/Munc18-a and syntaxin 1A regulates pre-synaptic release. Biochem Biophys Res Commun, 2006. 350(3): p. 691-7. 151. Kawauchi, T., et al., Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration. Nat Cell Biol, 2006. 8(1): p. 17-26. 152. Kawai, S., et al., Odd-skipped related 2 gene transcription is regulated by CCAAT enhancer-binding protein delta in mesenchymal C3H10T1/2 cells. Genes Cells, 2006. 11(2): p. 163-75. 153. Kato, T., et al., Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice. Cell Metab, 2006. 4(2): p. 143-54. 154. Kato, T., et al., Effect of phenytoin on collagen accumulation by human gingival fibroblasts exposed to TNF-alpha in vitro. Oral Dis, 2006. 12(2): p. 156-62. 155. Kapp-Barnea, Y., et al., Neuronal calcium sensor-1 and phosphatidylinositol 4-kinase beta stimulate extracellular signal-regulated kinase 1/2 signaling by accelerating recycling through the endocytic recycling compartment. Mol Biol Cell, 2006. 17(9): p. 4130-41. 156. Kano, F., K. Takenaka, and M. Murata, Reconstitution of Golgi disassembly by mitotic Xenopus egg extract in semi-intact MDCK cells. Methods Mol Biol, 2006. 322: p. 357-65. 157. Kang, M.J., et al., Caveolin-1 upregulation in senescent neurons alters amyloid precursor protein processing. Exp Mol Med, 2006. 38(2): p. 126-33. 158. Kamimoto, T., et al., Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity. J Biol Chem, 2006. 281(7): p. 4467-76. 159. Juge, N., et al., Vesicular glutamate transporter contains two independent transport machineries. J Biol Chem, 2006. 281(51): p. 39499-506. 160. Iwata, J., et al., Excess peroxisomes are degraded by autophagic machinery in mammals. J Biol Chem, 2006. 281(7): p. 4035-41. 161. Itoh, T., et al., Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. Genes Cells, 2006. 11(9): p. 1023-37. 162. Itoh, T. and M. Fukuda, Identification of EPI64 as a GTPase-activating protein specific for Rab27A. J Biol Chem, 2006. 281(42): p. 31823-31. 163. Itoh, T. and P. De Camilli, BAR, F-BAR (EFC) and ENTH/ANTH domains in the regulation of membrane-cytosol interfaces and membrane curvature. Biochim Biophys Acta, 2006. 1761(8): p. 897-912. 164. Ishizaki, R., et al., AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors. Genes Cells, 2006. 11(8): p. 949-59. 165. Ishikawa, T., et al., Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes. Cell Tissue Res, 2006. 323(2): p. 221-31. 166. Ishii, Y., et al., Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are vulnerable to injury. J Neurochem, 2006. 98(2): p. 588-600. 167. Ishida, Y., et al., Type I collagen in Hsp47-null cells is aggregated in endoplasmic reticulum and deficient in N-propeptide processing and fibrillogenesis. Mol Biol Cell, 2006. 17(5): p. 2346-55. 168. Inaba, H., et al., Association between epithelial cell death and invasion by microspheres conjugated to Porphyromonas gingivalis vesicles with different types of fimbriae. Infect Immun, 2006. 74(1): p. 734-9. 169. Imai, A., et al., Functional involvement of Noc2, a Rab27 effector, in rat parotid acinar cells. Arch Biochem Biophys, 2006. 455(2): p. 127-35. 170. Hosokawa, N., Y. Hara, and N. Mizushima, Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size. FEBS Lett, 2006. 580(11): p. 2623-9. 171. Hirata, T., et al., Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously. Development, 2006. 133(8): p. 1433-43. 172. Higashiyama, T., et al., Species preferentiality of the pollen tube attractant derived from the synergid cell of Torenia fournieri. Plant Physiol, 2006. 142(2): p. 481-91. 173. Hiasa, M. and Y. Moriyama, Immunohistochemical localization of d-aspartate in islets of langerhans. Biol Pharm Bull, 2006. 29(6): p. 1251-3. 174. Hiasa, M., et al., Wide variety of locations for rodent MATE1, a transporter protein that mediates the final excretion step for toxic organic cations. Am J Physiol Cell Physiol, 2006. 291(4): p. C678-86. 175. Herrero-Turrion, M.J., M. Fukuda, and F. Mollinedo, Cloning and genomic characterization of sytdep, a new synaptotagmin XIV-related gene. Biochem Biophys Res Commun, 2006. 340(2): p. 386-94. 176. Hatsuzawa, K., et al., Involvement of syntaxin 18, an endoplasmic reticulum (ER)-localized SNARE protein, in ER-mediated phagocytosis. Mol Biol Cell, 2006. 17(9): p. 3964-77. 177. Hase, K., et al., The membrane-bound chemokine CXCL16 expressed on follicle-associated epithelium and M cells mediates lympho-epithelial interaction in GALT. J Immunol, 2006. 176(1): p. 43-51. 178. Hara, T., et al., Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature, 2006. 441(7095): p. 885-9. 179. Handa, N., et al., The crystal structure of mouse Nup35 reveals atypical RNP motifs and novel homodimerization of the RRM domain. J Mol Biol, 2006. 363(1): p. 114-24. 180. Hama, K., et al., Lysophosphatidic receptor, LPA3, is positively and negatively regulated by progesterone and estrogen in the mouse uterus. Life Sci, 2006. 79(18): p. 1736-40. 181. Furutani, M., et al., Application of phosphoinositide-binding domains for the detection and quantification of specific phosphoinositides. Anal Biochem, 2006. 355(1): p. 8-18. 182. Furutani, M., et al., Thin layer chromatography-blotting, a novel method for the detection of phosphoinositides. J Biochem (Tokyo), 2006. 139(4): p. 663-70. 183. Furuta, K., et al., Membrane orientation of the precursor 74-kDa form of L-histidine decarboxylase. Inflamm Res, 2006. 55(5): p. 185-91. 184. Fukuda, M., Rab27 and its effectors in secretory granule exocytosis: a novel docking machinery composed of a Rab27.effector complex. Biochem Soc Trans, 2006. 34(Pt 5): p. 691-5. 185. Fukuda, M., Distinct Rab27A binding affinities of Slp2-a and Slac2-a/melanophilin: Hierarchy of Rab27A effectors. Biochem Biophys Res Commun, 2006. 343(2): p. 666-74. 186. Fukuda, M., Distinct developmental expression of synaptotagmin I and IX in the mouse brain. Neuroreport, 2006. 17(2): p. 179-82. 187. Fujiwara, T., et al., Analysis of knock-out mice to determine the role of HPC-1/syntaxin 1A in expressing synaptic plasticity. J Neurosci, 2006. 26(21): p. 5767-76. 188. Fatemi, S.H., et al., Chronic olanzapine treatment causes differential expression of genes in frontal cortex of rats as revealed by DNA microarray technique. Neuropsychopharmacology, 2006. 31(9): p. 1888-99. 189. Cheung, C., et al., Matrix metalloproteinases and tissue inhibitors of metalloproteinases in coxsackievirus-induced myocarditis. Cardiovasc Pathol, 2006. 15(2): p. 63-74. 190. Birmingham, C.L., et al., Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole. J Biol Chem, 2006. 281(16): p. 11374-83. 191. Asakura, M., T. Okuno, and Y. Takano, Multiple contributions of peroxisomal metabolic function to fungal pathogenicity in Colletotrichum lagenarium. Appl Environ Microbiol, 2006. 72(9): p. 6345-54. 192. Aratani, S., et al., The nuclear import of RNA helicase A is mediated by importin-alpha3. Biochem Biophys Res Commun, 2006. 340(1): p. 125-33. 193. Amano, A., I. Nakagawa, and T. Yoshimori, Autophagy in innate immunity against intracellular bacteria. J Biochem (Tokyo), 2006. 140(2): p. 161-6. 194. Amano, A., The oral microbiology research of Shigeyuki Hamada in the pre-genomic era. J Dent Res, 2006. 85(6): p. 501-4. 195. Akiyama, S., et al., Relationship of periodontal bacteria and Porphyromonas gingivalis fimA variations with phenytoin-induced gingival overgrowth. Oral Dis, 2006. 12(1): p. 51-6. 196. Adhami, F., et al., Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am J Pathol, 2006. 169(2): p. 566-83.