Table 5s: Genes down-regulated by both ethanol and n-butanol.
Systematic
name
YJR047C
YKR061W
YLL034C
YHR209W
YIL117C
YOR340C
YHL047C
YMR194W
YJR070C
YAL059W
YJL109C
YDL201W
YPL198W
YHR030C
YHR128W
YIL066C
YPL012W
YLR196W
YOR009W
YLR022C
YMR238W
YDR101C
YKR099W
YLR223C
YKR091W
YOR080W
YPL226W
YJL033W
YOL041C
YGR189C
YNL132W
Description
translation initiation factor eIF-5A, anaerobically expressed form
mannosyltransferase (putative)|type 2 membrane protein
Putative ATPase of the AAA family, required for export of pre-ribosomal
large subunits from the nucleus; distributed between the nucleolus,
nucleoplasm, and nuclear periphery depending on growth conditions
Putative S-adenosylmethionine-dependent methyltransferase of the seven
beta-strand family
Pheromone-regulated protein, predicted to have 1 transmembrane
segment; induced during cell integrity signalling
DNA dependent RNA polymerase I subunit A43
triacetylfusarinine C transporter
ribosomal protein L36A (L39) (YL39)
Protein that binds to the C-terminal domain of Hyp2p (eIF5A); has four to
five HEAT-like repeats
Protein of unknown function, localized in the nucleoplasm and the
nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit
export
U3 snoRNP protein
Subunit of a tRNA methyltransferase complex composed of Trm8p and
Trm82p that catalyzes 7-methylguanosine modification of tRNA
ribosomal protein L7B (L6B) (rp11) (YL8)
Suppressor of lyt2
UPRTase
ribonucleotide reductase, large (R1) subunit
Required for normal pre-rRNA Processing. Member of a group of seven
genes whose expression is repressed during growth on glucose before and
during the diauxic shift.
Protein with periodic trytophan residues that resembles members of betatransducin superfamily because of presence of WD-40 repeats
cell wall mannoprotein
Protein required for cell viability
Mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored
membrane protein required for cell wall biogenesis, involved in filamentous
growth, homologous to Dcw1p
--transcription factor
Essential protein with a highly acidic N-terminal domain; IFH1 exhibits
genetic interactions with FHL1, overexpression interferes with silencing at
telomeres and HM loci; potential Cdc28p substrate
Cytoplasmic protein that, when overexpressed, suppresses the lethality of a
rad53 null mutation; potential Cdc28p substrate
Protein of unknown function, involved in invasive and pseudohyphal growth
This gene encodes a protein with an Q/N-rich amino terminal domain that
acts as a prion, termed [NU]+.
RNA helicase (putative)
Nucleolar protein, required for pre-25S rRNA processing; contains an RNA
recognition motif (RRM) and has similarity to Nop13p, Nsr1p, and putative
orthologs in Drosophila and S. pombe
cell wall protein
Killer toxin REsistant
Stndard
name
ANB1
KTR2
ethanol
fold
change
9.943508
6.931792
butanol
fold
change
49.91542
3.938259
RIX7
6.929144
29.15893
6.35241
4.25416
PRM5
RPA43
ARN2
RPL36A
6.336404
6.048
5.33824
5.31805
16.17019
11.90551
5.955199
9.783639
LIA1
5.270697
11.49286
ECM1
UTP10
5.205433
5.107464
6.110613
14.92343
TRM8
RPL7B
SLT2
FUR1
RNR3
5.097241
5.041165
4.991965
4.990953
4.771885
19.86828
13.29336
4.821625
5.685295
12.73316
RRP12
4.702785
11.77186
PWP1
TIR4
SDO1
4.692346
4.669574
4.525581
14.89848
3.548258
4.914141
DFG5
ARX1
BAS1
4.446409
4.417974
4.391437
4.73233
16.38624
5.012216
IFH1
4.287206
3.748858
SRL3
DIA2
4.229859
4.204004
6.05013
7.57732
NEW1
HCA4
4.177521
4.141871
11.42627
8.037202
NOP12
CRH1
KRE33
4.077821
4.061059
4.033654
9.980952
8.127182
11.90071
YHR209W
YLR175W
YJR094W-A
YBL004W
YLR009W
YLR432W
YLR449W
YHL040C
YLR222C
YKL172W
YOR104W
YGL078C
YNL110C
YKL161C
YKR060W
YFL034C-A
YLR367W
YGR081C
YLL045C
YDR184C
YBR247C
YLR060W
YBR143C
YAL025C
YNR054C
YLR355C
YMR309C
YHR089C
YIL133C
YMR049C
YHR142W
YPL082C
YPL051W
YKR026C
YDR190C
YPR010C
YMR128W
YKL009W
YML022W
YLR406C
YGR245C
YJL010C
YKL082C
YKR024C
YPR112C
YDL166C
major low affinity 55 kDa centromere/microtubule binding protein
ribosomal protein L43B
U3 snoRNP protein
part of a pre-60S complex
IMP dehydrogenase homolog
peptidyl-prolyl cis-trans isomerase (PPIase)
Transporter, member of the ARN family of transporters that specifically
recognize siderophore-iron chelates; responsible for uptake of iron bound
to ferrirubin, ferrirhodin, and related siderophores
U3 snoRNP protein
nucleolar protein
[PSI+] induction
ATP dependent RNA helicase|dead/deah box protein CA3
ribosome biogenesis
Mpk1-like protein kinase; associates with Rlm1p
Possible U3 snoRNP protein involved in maturation of pre-18S rRNA,
based on computational analysis of large-scale protein-protein interaction
data
ribosomal protein L22B (L1c) (rp4) (YL31)
ribosomal protein S22B (S24B) (rp50) (YS22)
Protein of unknown function; deletion mutant has synthetic fitness defect
with an sgs1 deletion mutant
ribosomal protein L8B (L4B) (rp6) (YL5)
Nuclear protein, possibly involved in regulation of cation stress responses
and/or in the establishment of bipolar budding pattern
57 kDa protein with an apparent MW of 70 kDa by SDS-PAGE (putative)
phenylalanine-tRNA ligase subunit
eRF1 (eukaryotic Release Factor 1) homolog
nuclear protein (putative)
Protein required for cell viability
acetohydroxyacid reductoisomerase
translation initiation factor eIF3 subunit
small nucleolar RNP protein
ribosomal protein L16A (L21A) (rp22) (YL15)
Protein required for maturation of the 25S and 5.8S ribosomal RNAs;
homologous to mammalian Bop1
The seventh gene identified that is involved in chitin synthesis; involved in
Chs3p export from the ER
helicase (putative)
Similar to ADP-ribosylation factor. Part of the carboxypeptidase Y pathway.
eIF2B 34 kDa alpha subunit
RUVB-like protein, TIP49a Homologue
RNA polymerase I subunit
U3 snoRNP protein
Protein involved in mRNA turnover and ribosome assembly, localizes to the
nucleolus
adenine phosphoribosyltransferase
ribosomal protein L31B (L34B) (YL28)
Severe Depolymerization of Actin
Protein required for cell viability
Required for normal pre-rRNA Processing
RNA helicase (putative)
Essential conserved protein that associates with 35S precursor rRNA and
is required for its initial processing at the A(0)-A(2) cleavage sites, shows
partial nucleolar localization, contains five consensus RNA-binding domains
Essential nuclear protein, involved in the oxidative stress response
CBF5
RPL43B
UTP20
RLP24
IMD3
FPR4
4.010898
3.963027
3.961827
3.961351
3.912019
3.815077
15.85436
5.418309
8.144909
13.00972
4.119831
12.62768
ARN1
UTP13
EBP2
PIN2
DBP3
NOP15
YKL161C
3.788784
3.784244
3.781773
3.755538
3.755048
3.751731
3.735409
8.488774
18.41796
5.89372
4.179876
8.488889
8.250732
5.079365
UTP30
RPL22B
RPS22B
3.72327
3.717791
3.681528
16.44444
4.263852
11.25726
SLX9
RPL8B
3.679775
3.673766
5.261044
12.54299
ATC1
ENP1
FRS1
SUP45
MAK16
ESF2
ILV5
NIP1
GAR1
RPL16A
3.660759
3.635336
3.621895
3.619587
3.597917
3.593828
3.589816
3.51511
3.5
3.499824
4.32287
7.296454
8.816184
5.54954
6.853175
11.09138
9.124553
7.198312
9.029353
7.735518
ERB1
3.477925
14.25384
CHS7
MOT1
ARL3
GCN3
RVB1
RPA135
ECM16
3.466276
3.440488
3.436317
3.396083
3.395376
3.392757
3.392543
5.316342
3.745293
4.947955
7.101251
8.001932
8.787796
7.044086
MRT4
APT1
RPL31B
SDA1
YJL010C
RRP14
DBP7
3.386161
3.378409
3.368905
3.358696
3.311419
3.311255
3.288486
7.901042
6.061162
7.425894
5.421053
8.394737
10.33041
7.993711
MRD1
FAP7
3.280593
3.277108
13.20398
3.439928
YPL217C
YKL143W
YER145C
YLR130C
YDR441C
YLR061W
YDL075W
YPR163C
YLR106C
YFR001W
YMR319C
YML055W
YLR265C
YER045C
YMR229C
YLR401C
YOR216C
YDR496C
YPL093W
YJR002W
YHR148W
YPR143W
YLL011W
YNR053C
YKL006W
YGR151C
GTP-binding protein required for processing of 35S pre-rRNA at sites A0,
Protein required for viability at low temperature
iron permease
low affinity zinc transport protein
Apparent pseudogene, not transcribed or translated under normal
conditions; encodes a protein with similarity to adenine
phosphoribosyltransferase, but artificially expressed protein exhibits no
enzymatic activity
ribosomal protein L22A (L1c) (rp4) (YL31)
ribosomal protein L31A (L34A) (YL28) /// ribosomal protein L31B (L34B)
(YL28)
translation initiation factor eIF-4B
midasin
Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds
double-stranded RNA in vitro
--signal peptidase complex subunit|similar to mammalian protein SPC25
Mating-type regulated component of NHEJ
Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family,
may regulate transcription of genes involved in utilization of non-optimal
carbon sources
U3 snoRNP protein
dihydrouridine synthase 3
Novel matrix protein that is involved in the structural organization of the cisGolgi. Relieves uso1-1 transport defect; golgin-160 related protein.
member of
the PUF protein family
homologs identified in human and Trypanosoma brucei|nucleolar G-protein
(putative)
U3 snoRNP protein
U3 snoRNP protein
Protein required for cell viability
U3 snoRNP protein
part of a pre-60S complex
ribosomal protein L14A
Gtp-binding protein of the ras superfamily involved in bud site selection
BMS1
LTV1
FTR1
ZRT2
3.262921
3.256437
3.240099
3.234745
5.808
8.448898
3.62963
5.513498
APT2
RPL22A
3.221938
3.216722
3.863857
43.12709
RPL31A
TIF3
MDN1
3.211286
3.208214
3.193151
11.04741
10.43603
3.569678
LOC1
FET4
SPC2
NEJ1
3.189213
3.153161
3.151712
3.149938
7.875644
14.83039
9.126496
5.502165
ACA1
RRP5
DUS3
3.133333
3.129923
3.107492
4.049352
8.898327
5.088
RUD3
3.07277
6.14554
PUF6
3.059524
9.388128
NOG1
MPP10
IMP3
RRP15
SOF1
NOG2
RPL14A
RSR1
3.059322
3.057872
3.053435
3.052469
3.044232
3.029573
3.011876
3.002744
7.18408
3.49174
6.060606
4.654118
8.552477
8.684226
4.862958
4.908527