RESUME
EDWARD H. GERSTIN, JR.
Personal Details
Name:
Edward Harry Gerstin, Jr.
Home Address:
1408 38th Avenue, San Francisco, CA 94122
Business Address:
Incyte Genomics
3160 Porter Drive, Palo Alto, CA 94304
(650) 845-4692
E-mail Address:
gerstin@incyte.com
History
1999 - present
Senior Scientist/Scientist, IP Bioinformatics, Incyte Genomics, Palo Alto, CA
1997 - 1999
Patent Writer, Legal Department, Incyte Genomics, Palo Alto, CA
1995 - 1997
Post-doctoral Fellow, Ernest Gallo Clinic & Research Center, Department of Neurology
University of California, San Francisco
1990 - 1995
Ph.D. in Pharmacology and Toxicology, Department of Pharmacology, College of Medicine
University of California, Irvine
1989
B.A. in Biochemistry and Cell Biology, Department of Biology
University of California, San Diego
Experiences and Responsibilities
Industry-Related
• Co-lead a team of programmers and bioinformatics associates in the definition, design, development, testing,
and production deployment of methods for data analysis, data flow, and data management in the Intellectual
Property (IP) department
• Interface with IP department staff to develop innovative methods for high-throughput patent application and
prosecution processes
• Act as liaison between IP department and Research, Bioinformatics, and Product Science departments to
develop data and methods supporting Legal department functions
• Maintain IP Bioinformatics data quality, including gene assemblies, hand-edited full length genes, expression
data, genomic data, and annotation data
• Participate in the design, development, and implementation of an Oracle-based sequence tracking database, as
well as accompanying user interface
• Wrote numerous patent applications, and provided scientific input for patent prosecution
Academic
• Studied the PKC–dependent regulation of L–type calcium channels by chronic ethanol treatment, in the model
neuronal cell line PC12
• Wrote an NIH grant application for postdoctoral funding; funding awarded in 1996
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RESUME
EDWARD H. GERSTIN, JR.
• Characterized muscarinic acetylcholine receptor subtypes in rat peripheral lung by analyzing the
pharmacological antagonism of second messenger responses
• Studied the modulation of G-protein coupled receptor signaling pathways in three different tissues using
radioligand binding and second messenger assays
Technical Experiences
•
Bioinformatics/sequence analysis programs (HMMER, BLAST, BLIMPS, GCG)
•
PERL programming, including writing, testing, and implementing numerous PERL scripts
•
UNIX, Macintosh and PC environment
•
Courses in Relational Database Design, Introductory and Intermediate SQL
•
Molecular biology techniques, including RT-PCR, northern analysis, nucleic acid extraction/manipulation,
subcloning, and ribonuclease protection assays
•
Biochemical analyses of second messenger levels, including cAMP accumulation, adenylate cyclase activity
assays, and inositol phosphate accumulation assays, with extensive assay modification/optimization
•
Screening agonists using second messenger assays in various tissue preparations
•
Cell culture methods
Funding and Awards
1996 - 1997
NIAAA Grant, NRSA Postdoctoral Fellowship
1993 - 1994
Henry Wood Elliott Award, for Outstanding Graduate Student in Pharmacology
1990 - 1992
University of California Regents Fellowship
University Activities
1994
Student Representative, Self Study Task Force of Liaison Committee on Medical Education
1992 - 1994
Vice President - Internal Affairs, Associated Graduate Students
Military Duty
1985 – 1987
Specialist E4, US Army Biomedical Research and Development Laboratory, Fort Detrick, MD
Dissertation
“Modulation of Muscarinic Signaling” UMI Dissertation Services, Ann Arbor, MI, 1996
Invited Presentations
1997
PKC Isozymes That Mediate Chronic Responses to Ethanol, Annual Meeting of the Research
Society on Alcoholism
1995
Toxicology of the Central Nervous System and Eye, in Pharmacological Principles of Toxicology,
University of California, Irvine
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RESUME
EDWARD H. GERSTIN, JR.
Publications
•
GERSTIN, Jr., E.H., McMahon, T., Dadgar, J., Messing, R.O. Protein kinase C  mediates ethanol-induced upregulation of L-type calcium channels. J. Biol. Chem. 273: 16409-14 (1998)
•
Ehlert, F.J., Thomas, E.A., GERSTIN, Jr., E.H., Griffin, M.T. “Muscarinic Receptors and Gastrointestinal Smooth
Muscle.” In: Muscarinic Receptor Subtypes in Smooth Muscle, ed. R.M. Eglen, CRC Press, Inc., Boca Raton
(1996)
•
Esqueda, E.E., GERSTIN, Jr., E.H., Griffin, M.J., Ehlert, F.J. Stimulation of cAMP accumulation and
phosphoinositide hydrolysis by M3 muscarinic receptors in the rat peripheral lung. Biochem. Pharmacol. 52:
643-58 (1996)
•
GERSTIN, Jr., E.H., Ehlert, F.J. Inhibition of muscarinic stimulated phosphoinositide hydrolysis in the rat
parotid gland. Life Sci. 58: 145-153 (1996)
•
GERSTIN, Jr., E.H., Luong, T., Ehlert, F.J. Heparin, dextran, and trypan blue allosterically modulate M2
muscarinic receptor binding properties and interfere with receptor-mediated inhibition of adenylate cyclase. J.
Pharmacol. Exp. Ther. 263: 910-917 (1992)
Abstracts
•
GERSTIN, Jr., E. H., McMahon, T., Dadgar, J., Hundle, B., and Messing, R. Protein kinase C isozymes required
for up-regulation of L-type calcium channels by ethanol. Proceedings, Research Society on Alcoholism, 1996.
•
GERSTIN, Jr., E. H., and Ehlert, F. J. Evidence for muscarinic receptor cross-talk in the rat parotid gland.
Proceedings of the Sixth International Symposium on Subtypes of Muscarinic Receptors Life Sci 55: 110
(1994)
•
GERSTIN, Jr., E. H., Esqueda, E. E., and Ehlert, F. J. A pharmacological characterization of muscarinic receptor
subtypes mediating an increase in cAMP accumulation and phosphoinositide hydrolysis in the rat peripheral
lung. FASEB Journal 8: A88
•
GERSTIN, Jr., E. H., and Ehlert, F. J. Effects of cAMP on muscarinic receptor-mediated IP1 and IP3
accumulation in the rat parotid gland. Soc. Neurosci. Abs. 19: 1766 (1993)
•
GERSTIN, Jr., E.H., and Ehlert, F.J. Can increases in cellular c’AMP levels mediated by IBMX, histamine and
norphenylephrine dampen the phosphoinositide hydrolysis response to muscarinic agonists in the rat parotid
gland? Proceedings of the Western Pharmacology Society 36 (1993)
•
GERSTIN, Jr., E.H., and Ehlert, F.J. Evidence for interaction between the phosphoinositide and adenylate
cyclase signal transduction pathways in the rat parotid gland. Soc Neurosci Abs. 18: 1145 (1992)
•
GERSTIN, Jr., E.H., Luong, T., and Ehlert, F.J. Dextran and trypan blue interfere with muscarinic receptor -G
protein coupling in the rat heart. FASEB Journal 6: A1015 (1992)
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