CURRICULUM VITAE
Roger Powell Smith
Address:
Department of Pharmacology and Toxicology
Dartmouth Medical School
7650 Remsen, Room #519
Hanover, NH 03755-3835
P: 603-650-1668
F: 603-650-1129
E-Mail: roger.p.smith@dartmouth.edu
Birth: 16 July 1932, Hokuchin, Korea (of American parents)
Education:
Ph.D., Pharmaceutical Chemistry, Purdue University, 1957
M.S., Pharmaceutical Chemistry, Purdue University, 1955
B.S., Pharmacy, Purdue University, 1953
Licensure:
Registered Pharmacist, State of New Hampshire, 1977-2001
Military Service:
1/Lt., Medical Service Corps, USAR, USAEUR Medical Laboratory, Landstuhl,
Germany, 1957-60
Academic Appointments:
Irene Heinz Given Professor of Pharmacology and Toxicology, 1993-Emeritus
2000
Adjunct Professor of Environmental Studies, Dartmouth College, 1984-2000
Adjunct Professor, Vermont Law School, S. Royalton, 1981-87
Chairman, Department of Pharmacology and Toxicology, 1976-87
Professor of Pharmacology and Toxicology, 1976-93
Acting Chairman, Department of Pharmacology and Toxicology, 1975-76
Professor of Toxicology, 1973-76
Associate Professor of Toxicology, 1968-73
Assistant Professor of Toxicology, 1963-68
Instructor in Toxicology, 1960-63
Hospital Appointments:
1
Associate Consulting Staff, Mary Hitchcock MemorialHospital, 1968-96
Consultant, VA Hospital Medical Center, White River Junction, VT, 1968-91
Awards and Honors:
Faculty Marshall, Dartmouth Medical School Class Day Ceremony, 10
June 2000.
Distinguished Fellow of the Albert J. Ryan Foundation, 1997
Dartmouth Medical School Chapter of Alpha Omega Alpha, 1991
Mary Hitchcock Memorial Hospital Service Club, Permanent Member, 1991 (25
years service)
Fellow of The Academy of Toxicological Sciences with Certification in
Toxicology, 1989, Emeritus 1999
Distinguished Alumnus Award, Purdue University School of Pharmacy and
Pharmacal Sciences, 1986
MA (h.c.), Dartmouth College, 1975
USPHS Career Development Awardee, 1966-71
Fellow of the American Association for the Advancement of Science, 1962
National and Regional Committees:
National Research Council, Board on Environmental Studies and Toxicology,
Committee on Toxicology, Subcommittee to Review the Toxicity of
Nitrates and Nitrites in Drinking Water, 1994.
Chemical Substances Threshold Limit Value Committee, American Conference
of Governmental Industrial Hygienists, Inc., 1991-92
Toxicology Information Program Committee, National Research Council, 198688
Environmental Health Sciences Review Committee, NIEHS, NIH, 1985-87
Member of the Health Effects Institute Review Panel on Mechanisms of
CO Toxicity, Albuquerque, 1984
Chairman, WHO Task Group on Environmental Criteria for Hydrogen Sulfide,
Geneva, 1980.
Committee on Medical and Biological Effects of Environmental Pollutants,
Division of Medical Sciences, National Research Council, and Chairman,
Panel on Hydrogen Sulfide, 1975-77
United States Pharmacopeia Advisory Panel on Toxicology, 1974
Pharmacology-Toxicology Research Program Committee, NIGMS, 1972-76
Toxicology Study Section, NIH, 1969-72
ad hoc Advisory Group to the President on Nitrates, 1969
Institutional Committees:
Admissions Committee, 1997-98
Appointments, Promotions and Titles Committee, 1995-96
Rosaline Borison Memorial Predoctoral Fellowship Committee, 1993ad hoc Committee on the Global Environment, Dartmouth College, 1990-92
2
Faculty Promotions Committee, 1987-1992
Research Committee, 1977-78, 1987-91
VA Research and Development Committee, 1987-1990.
Advisory Board, 1973-87
Poison Control Center Committee, 1982-84
ad hoc Committee on Anatomy, 1979
MD-PhD Committee, 1975-78, Chairman, 1978-81
Curriculum Committee, 1972-79, Electives Subcommittee, 1975
ad hoc Search Committee for Senior Associate Dean, 1979
Committee on Student Performance, 1977-1995
ad hoc MD Curriculum Committee, 1977-78
Search Committee for Associat Dean for Administrative Affairs, 1976-77
Search Committee for Chair of Physiology, 1976
ad hoc Committee on Distilled Water, 1976
ad hoc Committee for Review of Chairmen and Deans, 1976
Chairman, ad hoc Search Committee for Associate Dean, 1976
ad hoc Committee on Research Professorships, 1975-76
Chairman, ad hoc Movable Equipment Committee, 1973
Admissions Committee, 1969-75, Equal Opportunity Subcommittee, 1972-74
Editorial Boards:
inScight, 1998-2000
Toxicological Sciences, 1998-2000
Human and Experimental Toxicology, 1994-97.
Fundamental and Applied Toxicology, 1992-97.
Toxicology, 1990-96.
Journal of Pharmacology and Experimental Therapeutics, 1978-1999.
Associate Editor, Toxicology and Applied Pharmacology, 1972-78.
Toxicology and Applied Pharmacology, 1970-72.
ad hoc Reviewer:
Revierer, ATSDR draft document, Medical Management Guideline on
Sulfur Dioxide, 2000.
Revierer, ATSDR draft document, Medical Management Guideline on
Hydrogen Cyanide, 2000.
Reviewer, ATSDR draft document, Toxicological Profile on Hydrogen Sulfide,
2004.
American Journal of Physiology: Heart and Circulatory Physiology
Toxicology and Applied Pharmacology
Handbook of Hazardous Materials
Canadian Journal of Physiology and Pharmacology
Applied Occupational and Environmental Hygiene
Critical Reviews in Toxicology
Annals of Internal Medicine (Ranked in top 30% of reviewers in '95 and '99; top
10% in 1996)
3
Human Pharmacology
Pharmacological Reviews
Biochemical Pharmacology
Journal of Toxicology, Clinical Toxicology
Jounal of Cardiovascular Pharmacology
Biochemical Journal
Journal of the Air and Waste Management Association
Environmental Health Perspectives
Encyclopedia of Chemical Technology
Journal of Clinical Investigation
Blood
Esperimental Neurology
Molecular Pharmacology
Food and Cosmetic Toxicology
Professional Societies:
Society of the Sigma Xi, Associate 1956, Full 1969, Emeritus 1997.
American Association for the Advancement of Science, 1960-Emeritus 2000
(Fellow 1962)
American Association of Poison Control Centers, 1963-85 (Treasurer 1964-68)
Society of Toxicology, 1966-Retired 2000 (Education Committee, 1979-81)
American Society for Pharmacology and Experimental Therapeutics,1967Retired
2000
Society for Experimental Biology and Medicine, 1975-1989
American Conference of Governmental Industrial Hygienists, Inc., 1992-95
Teaching:
Course Director, Pharmacology 121, Medical Pharmacology, 1975-93,
Participant, 1994-98 (9 lecture hours in 1996; 8 in 1997; 2 in 1998)
Course Director, Pharmacology 124, Ethical Conduct of Research, 1991-97 (3
lecture hours in 1995-97)
CoDirector, ENVS 45, Environmental Health, 1984-94
Participant, Pharmacology 123, Graduate Toxicology, Fall term 1992-98 (6
lecture hours in 1995; 4 in 1998))
Participant, Pharmacology 130, Graduate Pharmacology, Fall term 1994- (1
lecture hour in 1995 and 1997)
Participant, Clinical Pharmacology and Therapeutics, 1984-95 (1 lecture hour
in 1995)
Research Funding:
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HL 14127-32, Toxicology of Vasoactive-Heme Reactive Compounds, Total
project period 04/01/94 to 03/31/97, Total direct
costs for last project period
$140,689. Roger P Smith PI, 40% effort. No cost extension to 03/31/98.
Albert J. Ryan Foundation, Cincinnati, OH, Funds for the unrestricted support of
graduate students, Total project period indefinite, Total direct costs for last
project year $43,000 (divided among three departmental Ph. D. programs in the
medical school). Roger P. Smith, Institutional Representative, 5% effort. 197797.
Invited Presentations:
Two-way Radio Conference Program, "Recognition and Management of
Pesticide Poisoning", Albany Medical College, Department of Postgraduate
Medicine, 13 February 1962, 4 and 7 February 1963.
Invited Speaker, Graduate School of Credit and Financial Management of the
National Association of Credit Management" Dartmouth College, 8 August
1963, "Economic Poisons and Mans' Health".
WTSL, Breakfast at the Hanover Inn, 16 March 1964, "Poison Information
Week".
Invited Seminar, University of Montreal, 4 June 1969, "Toxicology of Hydrogen
Sulfide".
Invited Seminar, Harvard University, School of Public Health, 7 April 1970,
"Chemically-induced Methemoglobinemia".
Invited Speaker, New England Council of Hospital Pharmacists, 19 October
1971, "The Role of the Pharmacist in Poison Control and Toxicology".
Invited Seminar, University of Rhode Island, 5 May 1971, "Acute Hydrogen
Sulfide Poisoning".
Faculty, Breathalyzer School, Alcohol and Saftey Action Project, NH
Police Standards and Training Council, 1971-84.
Invited Speaker, Postgraduate Assembly in Anesthesiology Symposium, The
New York Hilton, "Some Toxicologic Problems of Today's Environment", 13
December 1972.
Invited Seminar, Atomic Energy of Canada Limited, Chalk River Nuclear
Laboratories, Ontario, 30 August 1977, "Toxicology of Hydrogen Sulfide".
Invited Speaker, Atomic Energy of Canada, Ltd., Glace Bay Heavy Water Plant,
Nova Scotia, 17 September 1977, Hydrogen Sulphide Medical Seminar".
Invited Seminar, University of Massachusetts Medical Center, 26 October 1979,
"Hydrogen Sulfide Poisoning and Its Management".
Faculty, Mid-America Toxicology Course, Kansas City, 1981Invited Speaker at Symposium organized by the Governor"s Blue Ribbon
Commission on Public Health in the 80's, Concord, NH, 21 July 1981.
Invited Seminar, University of Vermont Medical School, 5 December 1985,
"Hemoglobin X: A Phenomenon Explained At Last".
Co-organizer and Lecturer, Dartmouth-Hitchcock Medical Center
Annual CME Series, "Topics in Emergency Medicine, Poisonings and
Toxicology", 1985-
5
Invited Speaker, Pesticide Dealer Training Seminar, Vermont Department of
Agriculture, 28 October 1987, "Toxic Effects of Pesticides".
Invited Seminar, University of Cincinnati, Institute of Environmental Health, 27
January 1988, "Bioactivation of Nitrogenous Vasodilators to Nitric Oxide".
Invited Participant, NATO Advanced Studies Institute, "Vascular
Endothelium: Receptors and Transduction Mechanisms", Porto
Carras, Halkidiki, Greece, June 18-29, 1988
Invited Speaker, The Robert V. Blanke Symposium, Medical College of
Virginia, Richmond, October 28, 1988.
Invited Keynote Speaker, International Conference on Hydrogen Sulphide
Toxicity, Banff, Alberta, Canada, June 18-21, 1989.
Invited Speaker, International Symposium on Chlorine Dioxide:
Scientific, Regulatory and Application Issues. The Chemical
Manufacturers Association, The American Water Works Association
Research Foundation and the United States Environmental Protection
Agency, Denver, CO, November 1-2, 1989.
Invited Seminar, Food and Drug Administration, Department of Health and
Human Services, 21 February 1990, "Reactions of Hemoglobin with
Xenobiotics".
Invited Seminar, Uniformed Services University of the Health Sciences, 6 March
1990, "Mechanisms of Nitric Oxide Release from Exogenous
Vasodilators".
Invited Participant, "International Symposium on Biologically Reactive
Intermediates IV: Molecular and Cellular Effects and Human Impact".
Tuscon, AZ, January 14-17, 1990.
Invited Speaker, Marine Chemist Association, Inc., Annual Seminar,
Chicago, IL, July 9-11, 1991.
Invited Participant, Second International Meeting, Biology of Nitric
Oxide, London, 30 Sept.-2 Oct., 1991.
Invited Seminar, Purdue University, School of Pharmacy and Pharmacal
Sciences, 30 July 1992, "Vignettes on the Pharmacology of Nitric Oxide".
Invited Seminar, University of Connecticut, Center for Biochemical Toxicology,
29 October 1992, "Vignettes on the Pharmacology of Nitric Oxide".
Invited Seminar, Wyeth Ayerst Drug Safety, Chazy, NY, 22 September 1997,
"Interactions of Vitamin B12 and Nitric Oxide".
Guest Speaker, Sigma Xi Induction and Awards Ceremony, Dartmouth College,
10 June 1999, "Desperately Seeking Sulfide".
Bibliography:
Books:
Gleason, M. N., R. E. Gosselin, H. C. Hodge and R. P. Smith (1969). Clinical
Toxicology of Commercial Products, 3rd ed., Williams and Wilkins, Baltimore.
Gosselin, R. E., H. C. Hodge, R. P. Smith and M. N. Gleason (1976). Clinical
Toxicology of Commercial Products, 4th ed. Williams and Wilkins, Baltimore.
6
Hydrogen Sulfide, A Report by the Subcommittee on Hydrogen Sulfide (chaired
by R. P. Smith) of the Committee on Medical and Biologic Effects of
Environmental Pollutants, Assembly of Life Sciences, National Research
Council, National Academy of Sciences, Washington, D. C., 1977. Reprinted by
University Park Press, Baltimore, 1979.
Hydrogen Sulfide, Who Task Group on Environmental Health Criteria for
Hydrogen Sulfide (chaired by R. P. Smith) World Health Organization,
Environmental Health Criteria 19, Geneva, 1981.
Gosselin, R. E., R. P. Smith and H. C. Hodge (1984). Clinical Toxicology of
Commercial Products, 5th ed., Williams and Wilkins, Baltimore.
Nierenberg, D. W. and R. P. Smith (1988). Clinical Problems in Basic
Pharmacology. C. V. Mosby Co., St. Louis.
Smith, R. P. (1992). A Primer of Environmental Toxicology, Lea and Febiger,
Malvern, PA. Nominated for the 1995 Rutstrum Author's Award of the Rutstrum
Wilderness Trust.
Book Chapters:
Smith, R. P. (1959). Alkaloid biogenesis. In Modern Pharmacognosy (E.
Ramstad, Ed.) McGraw-Hill, New York.
Gosselin, R. E., and R. P. Smith (1963). Ingredients index and Therapeutics
index. In Clinical Toxicology of Commercial Products (M. N. Gleason, R.
Gosselin and H. C. Hodge, Ed.) Williams and Wilkins, Baltimore.
Smith, R. P. (1969). The significance of methemoglobinemia in toxicology. In
Essays in Toxicology, Vol. 1 (F. R. Blood, Ed.) Academic Press, New York.
Smith, R. P. (1975). Chapter 10. Toxicology of the formed elements of the
blood. In Toxicology, The Basic Science of Poisons (L. J. Casarett and J. Doull,
Ed.) Macmillan, New York.
Smith, R. P., and R. E. Gosselin (1976). Current concepts about the treatment
of selected poisonings: Nitrite, cyanide, sulfide, barium and quinidine. Ann. Rev.
Pharmacol. Toxicol. 16:189-199.
Smith, R. P. (1980). Chapter 14. Toxic responses of the blood. In Casarett and
Doull's Toxicology, The Basic Science of Poisons, 2nd ed. (J. Doull, C. D.
Klaassen and M. O. Amdur, Ed.) Macmillan, New York.
Smith, R. P. (1980). Mammalian toxicology and human health effects. In
Ambient Water Quality Criteria for Cyanides. USEPA, Office of Water
7
Regulation and Standards, Criteria and Standards Division, Washington, D. C.
EPA 440/5-80-037, October.
Norton, J. M., and R. P. Smith (1981). Drugs affecting the oxygen transport
function of hemoglobin. In Respiratory Pharmacology, Section 104, International
Encyclopedia of Pharmacology and Therapeutics (J. Widdicombe, Section Ed.)
Pergamon Press, Oxford.
Smith, R. P. (1985). Alleged neurotoxic effects of chronic cyanide exposure. In
Neurotoxicology (K. Blum and L. Manzo, Ed.) Marcel Dekker, Inc., New York.
Smith, R. P. (1986). Chapter 8. Toxic responses of the blood. In Casarett and
Doull's Toxicology, The Basic Science of Poisons, 3rd ed. (C. Klaassen, M. O.
Amdur and J. Doull, Ed.) Macmillan, New York.
Smith, R. P. (1991). Chapter 8. Toxic responses of the blood. In Casarett and
Doull's Toxicology: The Basic Science of Poisons, 4th ed. ( M. O. Amdur, J.
Doull and C. D. Klaassen, Ed.) Macmillan, New York.
Plaa, G. L., and R. P. Smith. (1995). Chapter 104. General principles of
toxicology. In Section XIII. Elements of Toxicology (G. L. Plaa and R. P. Smith,
Ed.) of Human Pharmacology (P. L. Munson, Ed.) Chapman and Hall, New York
pp. 1537-1543.
Smith, R. P. (1995). Chapter 112. Systemic antidotes. In Section XIII.
Elements of Toxicology (G. L. Plaa and R. P. Smith, Ed.) of Human
Pharmacology (P. L. Munson, Ed.) Chapman and Hall, New York, pp 16391640.
Smith, R. P. (1996). Chapter 11. Toxic responses of the blood. In Casarett
and Doull's Toxicology: The Basic Science of Poisons, 5th ed. (C. D. Klaassen,
Ed.) Macmillan, New York, pp. 335-354.
Rochelle, L. G., H. Kruszyna and R. P. Smith (1996). Chapter 1. Electron
paramagnetic resonance detection of nitric oxide in biological samples. In Nitric
Oxide Synthase, Characterization and Functional Analysis, (M. D. Maines, Ed)
Academic Press, New York, pp. 3-13. [Methods in Neurosciences, Vol 31].
Symposia:
Smith, R. P., and H. Kruszyna (1976). Toxicology of some inorganic
antihypertensive anions. Fed. Proc. 35:69-72. In Biochemical Aspects of Toxic
Aents, (G. L. Plaa, Ed.) ASPET Fall Meeting, Université de Montréal, August 1822, 1974.
Smith, R. P. Keynote speaker. (1990). Hydrogen sulfide: Overview, history,
theories and unknowns. In Proceedings of International Conference on
8
Hydrogen Sulphide Toxicity (M. G. Prior, S. H. Roth, F. H. Y. Green, W. C.
Hulbert and R. Reiffenstein, Ed.) Banff, Alberta, Canada, June 18-21, 1989.
Sulfide Research Network, Department of Pharmacology, University of Alberta,
Edmonton, Alberta, Canada.
Smith, R. P., D. E. Wilcox, H. Kruszyna and R. Kruszyna (1990). Nitroprusside,
a potpourri of biologically reactive intermediates. In Biological Reactive
Intermediates IV: Molecular and Cellular Effects and Their Impact. on Human
Health, (C. M. Witmer, R. R. Snyder, D. J. Jollow, G. F. Kalf, J. J. Kocsis, and I.
G. Sipes, Ed.), Plenum Press, New York (Advances in Experimental Medicine
and Biology , Volume 283).
Huot, A. E., E. Schiffeleers, H. Kruszyna, R. Kruszyna, R. P. Smith and M. P.
Hacker (1991). Altered hemoglobin in erythrocytes exposed to nitric oxide
secreting alveolar macrophages. In Biology of Nitric Oxide, Part II, Enzymology,
Biochemistry and Immunology, (S. Moncada, M. A. Marletta, J. B. Hibbs, Jr. and
E. A. Higgs, Ed.), Portland Press, Colchester UK, 1992, pp. 159-162.
Smith, R. P., L. R. Cantilena, S. Frasur, H. Kruszyna, R. Kruszyna, and D. E.
Wilcox (1992). Nitric oxide hemoglobin (HbNO): Stability, detection in patients
receiving nitroglycerin and lack of endogenous basal levels. In Biology of Nitric
Oxide, Part I, Physiological and Clinical Aspects, (S. Moncada, M. A. Marletta, J.
B. Hibbs, Jr. and E. A. Higgs, Ed.), Portland Press, Colchester UK, 1992, pp.
355-357.
Journal Articles:
Smith, R. P., G. E. Cwalina and E. Ramstad (l959). Studies on glutamic acid
decarboxylase. J. Am. Pharm. Assoc., Sci. Ed. 48:103-105.
Smith, R. P. (1959). A poison control center in Europe. Med. Bull. U. S. Army,
Europe 16:87-89.
Berninger, H., and R. Smith (1959). A modification of the spectrophotometric
determination of carbon monoxide in blood enabling direct determination of per
cent hemoglobin saturation. Clin. Chem. 5:127-134.
Leahy, T., and R. Smith (1960). Notes on methemoglobin determination. Clin.
Chem. 6:148-152 and Erratum, Ibid. 7:148, 1961.
Smith, R. P. (1961). A poison information center for American armed forces in
Europe. Mil. Med. 126:218-222.
Smith, R. P., and D. M. Smith (1961). Acute ipecac poisoning--report of a fatal
case and review of the literature. N. Engl. J. Med. 265:523-525.
9
Smith, R. P. (1961). Trends in poison control. Health News 38:No. 9, 13-16.
Abbanat, R. A., and R. P. Smith (1964). The influence of methemoglobinemia
on the lethality of some toxic anions. I. Azide. Toxicol. Appl. Pharmacol. 6:576583.
Smith, R. P., and R. E. Gosselin (1964). The influence of methemoglobinemia
on the lethality of some toxic anions. II. Sulfide. Toxicol. Appl. Pharmacol.
6:584-592.
Smith, R. P., and R. E. Gosselin (1966). On the mechanism of sulfide
inactivation by methemoglobin. Toxicol. Appl. Pharmacol. 8:159-172.
Stolk, J. M., and R. P. Smith (1966). Species differences in methemoglobin
reductase activity. Biochem. Pharmacol. 15:343-351.
Vaughan, M. C., R. P. Smith and R. E. Gosselin (1966). Effects of oxygen on
determination of thiocholine by 5,5-dinitrobis(2-nitrobenzoic acid). Proc. Soc.
Exp. Biol. Med. 122:50-55.
Gosselin, R. E., and R. P. Smith (1966). Trends in the therapy of acute
poisonings. Clin. Pharmacol. Ther. 7:279-299. Reprinted in Australasian J.
Pharm. Sci., Supple. 48:S2-S8 and S12-S18, 1967.
Smith, R. P., and R. A. Abbanat (1966). Protective effects of oxidized
glutathione in acute sulfide poisoning. Toxicol. Appl. Pharmacol. 9:209-217.
Smith, R. P., A. A. Alkaitis and P. R. Shafer (1967). Chemically-induced
methemoglobinemias in the mouse. Biochem. Pharmacol. 16:317-328.
Smith, R. P., R. E. Gosselin, J. A. Henderson and D. M. Anderson (1967).
Comparison of the adsorptive properties of activated charcoal and Alaskan
montmorillonite for some common poisons. Toxicol. Appl. Pharmacol. 10:95104.
Smith, R. P. (1967). The nitrite-methemoglobin complex--its significance in
methemoglobin analyses and its possible role in methemoglobinemia. Biochem.
Pharmacol. 16:1655-1664.
Smith, R. P. (1967). The oxygen and sulfide binding characteristics of
hemoglobins generated from methemoglobin by two erythrocytic systems. Mol.
Pharmacol. 3:378-385.
Colton, T., R. E. Gosselin and R. P. Smith (1968). The tolerance of coffee
drinkers to caffeine. Clin. Pharmacol. Ther. 9:31-39.
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Klurfeld, G., and R. P. Smith (1968). Effects of chloride and bicarbonate on
methemoglobin reduction in mouse erythrocytes. Biochem. Pharmacol.
17:1067-1077.
Smith, R. P., and W. R. Layne (1969). A comparison of the lethal effects of
nitrite and hydroxylamine in the mouse. J. Pharmacol. Exp. Ther. 165:30-35.
Layne, W. R., and R. P. Smith (1969). Methylene blue and the reversal of
chemically-induced methemoglobinemias in human erythrocytes. J. Pharmacol.
Exp. Ther. 165:36-44
Smith, R. P. (1969). Cobalt salts: Effects in cyanide and sulfide poisoning and
on methemoglobinemia. Toxicol. Appl. Pharmacol. 15:505-516.
Smith, R. P. (1970). Some features of the reaction between cobaltinitrite and
hemoglobin. Toxicol. Appl. Pharmacol. 17:634-647.
Cranston, R. D., and R. P. Smith (1971). Some aspects of the reactions
between hydroxylamine and hemoglobin derivatives. J. Pharmacol. Exp. Ther.
177:440-446.
Smith, R. P. (1971). Cobalt lysis and methemoglobin accumulation in human
erythrocyte suspensions. Proc. Soc. Exp. Biol. Med. 136:701-706.
Smith, R. P. (1971). Spectrophotometric determination of methemoglobin and
oxyhemoglobin in the presence of methylene blue. Clin. Toxicol. 4:273-285.
Bolyai, J. Z., R. P. Smith and C. T. Gray (1972). Ascorbic acid and chemicallyinduced methemoglobinemia. Toxicol. Appl. Pharmacol. 21:176-185.
Smith, R. P., and C. D. Thron (1972). Hemoglobin, methylene blue, oxygen
interactions in human red cells. J. Pharmacol. Exp. Ther. 183:549-558.
Smith, R. P. (1973). Cyanate and thiocyanate: Acute toxicity. Proc. Soc. Exp.
Biol. Med. 142:1041-1044.
Smith, R. P., and M. V. Olson (1973). Drug-induced methemoglobinemia.
Semin. Hematol. 10:253-268. Reprinted (in Italian) in Aggiorn. Ematol. 12:103125, 1975.
Felsenstein, W. C., R. P. Smith and R. E. Gosselin (1974). Toxicologic studies
on the avicide, 3-chloro-p-toluidine. Toxicol. Appl. Pharmacol. 28:110-125.
Smith, R. P., and H. Kruszyna (1974). Nitroprusside produces cyanide poisoning
via a reaction with hemoglobin. J. Pharmacol. Exp. Ther. 191:557-563.
11
Kruszyna, R., and R. P. Smith (1975). A method for discriminating between
chemically induced changes in locomotor activity and whole body oxygen
consumption in mice. Toxicol. Appl. Pharmacol. 31:390-402.
Borison, H. L., S. R. Snow, D. S. Longnecker and R. P. Smith (1975). 3-Chlorop-toluidine: effects of lethal doses in rats and cats. Toxicol. Appl. Pharmacol.
31:403-412.
Kruszyna, H., R. Kruszyna and R. P. Smith (1975). Calibration of a turbidimetric
method for sulfide. Anal. Biochem. 69:643-645.
Smith, R. P., R. Kruszyna and H. Kruszyna (1976). Management of acute sulfide
poisoning, effects of oxygen, thiosulfate and nitrite. Arch. Environ. Health
31:166-169.
Norton, J. M., and R. P. Smith (1976). Drugs acting on hemoglobin and the
oxygen transport system. Pharmacol. Ther. B 2:523-538.
Smith, L., H. Kruszyna and R. P. Smith (1977). The effect of methemoglobin on
the inhibition of cytochrome c oxidase by cyanide, sulfide or azide. Biochem.
Pharmacol. 26:2247-2250.
Kruszyna, R., R. P. Smith and L. C. Ou (1977). Method for measuring increased
plasma hemoglobin in the presence of erythrocytes. Clin. Chem. 23:2156-2159.
Ou, L. C., and R. P. Smith (1978). Hemoglobinemia in rats exposed to high
altitude. Exp. Hemat. 6:473-478.
Susman, J. L., J. F. Hornig, S. C. Thomae and R. P. Smith (1978). Pulmonary
excretion of hydrogen sulfide, methanethiol, dimethyl sulfide and dimethyl
disulfide in mice. Drug. Chem. Toxicol. 1:327-338.
Smith, R. P., R. Kruszyna and L. C. Ou (1979). Hemoglobinemia in rats
exposed to high altitude is not due to an overload of catabolic mechanisms.
Aviat. Space Environ. Med. 50:9-13.
Smith, R. P., and R. E. Gosselin (1979). Hydrogen sulfide poisoning. J. Occup.
Med. 21:93-97.
Smith, R. P., R. Kruszyna and L. C. Ou (1979). Hemoglobinemia in mice
exposed to high altitude. Pflugers Arch. 389:65-70.
Doherty, P. A., D. Van Riper, W. O. Berndt and R. P. Smith (1979). Failure of
oxygen to influence the metabolism or distribution of cyanide or of thiosulfate in
mice. Toxicol. Lett. 4:25-29.
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Ou, L. C., D. Kim, W. M. Layton, Jr. and R. P. Smith (1980). Splenic
erythropoiesis in polycythemic response of the rat to high altitude exposure. J.
Appl. Physiol.: Respirat. Environ. Exercise Physiol. 48:857-861.
Kruszyna, H., R. Kruszyna, J. Hurst and R. P. Smith (1980). Toxicology and
pharmacology of some ruthenium compounds: Vascular smooth muscle
relaxation by nitrosyl derivatives of ruthenium and iridium. J. Toxicol. Environ.
Health 6:757-773.
Ou, L. C., and R. P. Smith (1981). Splenic origin of early-labeled bilirubin in rats
exposed to high altitude. Proc. Soc. Exp. Biol. Med. 166:287-290.
Willhite, C. C., V. H. Ferm and R. P. Smith (1981). Teratogenic effects of
aliphatic nitriles. Teratology 23:317-323.
Willhite, C. C., M. Marin-Padilla, V. H. Ferm and R. P. Smith (1981).
Morphogenesis of axial skeletal (dysraphic) disorders induced by aliphatic
nitriles. Teratology 23:325-333.
Willhite, C. C., and R. P. Smith (1981). The role of cyanide liberation in the
acute toxicity of aliphatic nitriles. Toxicol. Appl. Pharmacol. 59:589-602.
Kruszyna, H., R. Kruszyna and R. P. Smith (1981). Detergent-catalyzed
autoxidation of hemoglobin--species differences and implications for
methemoglobin analyses. Arch. Toxicol. 49:43-48.
Kruszyna, R., H. Kruszyna and R. P. Smith (1982). Comparison of
hydroxylamine, 4-dimethylaminophenol and nitrite protection against cyanide
poisoning in mice. Arch. Toxicol. 49:191-202.
Doherty, P. A., V. H. Ferm and R. P. Smith (1982). Congenital malformations
induced by infusion of sodium cyanide in the golden hamster. Toxicol. Appl.
Pharmacol. 64:456-464.
Kruszyna, H., R. Kruszyna and R. P. Smith (1982). Nitroprusside increases
cyclic guanylate monophosphate concentrations during relaxation of rabbit aortic
strips and both effects are antagonized by cyanide. Anesthesiology 57:303308.
Doherty, P. A., R. P. Smith and V. H. Ferm (1982). Tetramethyl substitution on
succinonitrile confers pentylenetetrazole-like activity and blocks cyanide release
in mice. J. Pharmacol. Exp. Ther. 223:635-641.
Doherty, P. A., R. P. Smith and V. H. Ferm (1983). Comparison of the
teratogenic potential of two aliphatic nitriles in hamsters: succinonitrile and
tetramethylsuccinonitrile. Fund. Appl. Pharmacol. 3:41-48.
13
Vitkun, S. A., R. P. Smith, E. E. French, W. H. Edwards and N. Watkins (1983).
Heinz body hemolytic anemia in newborns and failure of laboratory studies to
implicate a phenolic disinfectant. Pediatrics 71:352-358.
Horner, H. C., B. D. Roebuck, R. P. Smith and J. P. English (1983). Acute
toxicity of some silver salts of sulfonamides in mice and the efficacy of
penicillamine in silver poisoning. Drug Chem. Toxicol. 6:267-277.
Ou, L. C., and R. P. Smith (1983). Probable strain differences of rats in
susceptibilities and cardiopulmonary responses to chronic hypoxia. Resp.
Physiol. 53:367-377.
Schwerin, F. T., R. Rosenstein and R. P. Smith (1983). Cyanide prevents the
inhibition of platelet aggregation by nitroprusside, hydroxylamine and azide.
Thromb. Haemostas. 50:780-783.
Ou, L. C., and R. P. Smith (1984). Strain and sex differences in the
cardiopulmonary adaptation of rats to high altitude. Proc. Soc. Exp. Biol. Med.
177:308-311.
Kruszyna, R., H. Kruszyna, P. A. Doherty and R. P. Smith (1984). Hypotensive
effects of hydroxylamine in intact anesthetized dogs and cats. Arch. Toxicol.
55:203-205.
Kaplita, P. V., H. L. Borison, L. E. McCarthy and R. P. Smith (1984). Peripheral
and central actions of sodium azide on circulatory and respiratory homeostasis in
anesthetized cats. J. Pharmacol. Exp. Ther. 231:189-196.
Rutkowski, J. V., B. D. Roebuck and R. P. Smith (1985). Effects of protein-free
diet and food deprivation on hepatic rhodanese activity, serum proteins and
acute cyanide lethality in mice. J. Nutr. 115:132-137 and Erratum, Ibid.
115:415, 1985.
Williams, K. J., R. Rosenstein and R. P. Smith (1985). Substitution of
tetramethylbenzidine for benzidine in cyanide analyses. Clin. Chim. Acta
145:113-118.
Kruszyna, H., R. Kruszyna and R. P. Smith (1985). Cyanide and sulfide interact
with nitrogenous compounds to influence the relaxation of various smooth
muscles. Proc. Soc. Exp. Biol. Med. 179:44-49.
Rutkowski, J. V., B. D. Roebuck and R. P. Smith (1986). Liver damage does not
increase the sensitivity of mice to cyanide given acutely. Toxicology 38:305314.
Kaplita, P. V., and R. P. Smith (1986). Pathways for the bioactivation of aliphatic
nitriles to free cyanide in mice. Toxicol. Appl. Pharmacol. 84:533-540.
14
Rutkowski, J. V., B. D. Roebuck and R. P. Smith (1986). Allyl alcohol partially
protects murine hepatic mitochondria against carbon tetrachloride. Toxicology
40:25-30.
Kruszyna, R., H. Kruszyna, R. P. Smith, C. D. Thron and D. E. Wilcox (1987).
Nitrite conversion to nitric oxide in red cells and its stabilization as a nitrosylated
valency hybrid of hemoglobin. J. Pharmacol. Exp. Ther. 241:307-313.
Jacobs, J. M., J. V. Rutkowski, B. D. Roebuck and R. P. Smith (1987). Rat
hepatic mitochondria are more sensitive to allyl alcohol than are those of mice.
Toxicol. Lett. 38:257-264.
Hill, N. C., L. C. Ou, C. D. Thron and R. P. Smith (1987). Time course of
cardiopulmonary responses to high altitude in susceptible and resistant rat
strains. Resp. Physiol. 70:241-249.
Kruszyna, H., R. Kruszyna, R. P. Smith and D. E. Wilcox (1987). Red blood cells
generate nitric oxide from directly acting nitrogenous vasodilators. Toxicol. Appl.
Pharmacol. 91:429-438.
Kruszyna, R., H. Kruszyna, R. P. Smith and D. E. Wilcox (1988). Generation of
valency hybrids and nitrosylated species of hemoglobin in mice by nitric oxide
vasodilators. Toxicol. Appl. Pharmacol. 94:458-465.
Devlin, D. J., J. W. Mills and R. P. Smith (1989). Histochemical localization of
rhodanese activity in rat liver and skeletal muscle. Toxicol. Appl. Pharmacol.
97:247-255.
Devlin, D. J., R. P. Smith and C. D. Thron (1989). Cyanide metabolism in the
isolated, perfused, bloodless hindlimbs or liver of the rat. Toxicol. Appl.
Pharmacol. 98:338-349.
Shafer, P. R., D. E. Wilcox, H. Kruszyna, R. Kruszyna and R. P. Smith (1989).
Decomposition and specific exchange of the trans-cyanide ligand on
nitroprusside is facilitated by hemoglobin. Toxicol. Appl. Pharmacol. 99:1-10.
Devlin, D. J., R. P. Smith and C. D. Thron (1989). Cyanide release from
nitroprusside in the isolated, perfused, bloodless liver and hindlimbs of the rat.
Toxicol. Appl. Pharmacol. 99:354-356.
Smith, R. P., and C. C. Willhite (1990). Chlorine dioxide and hemodialysis.
Reg. Toxicol. Pharmacol. 11:42-62.
Wilcox, D. E., H. Kruszyna, R. Kruszyna and R. P. Smith (1990). Effect of
cyanide on the reaction of nitroprusside with hemoglobin: Relevance to cyanide
15
interference with the biological activity of nitroprusside. Chem. Res. Toxicol.
3:71-76.
Sana, T. R., V. H. Ferm, R. P. Smith, R. Kruszyna, H. Kruszyna, and D. E.
Wilcox (1990). Embryotoxic effects of sodium azide infusions in the Syrian
hamster. Fund. Appl. Toxicol. 15:754-759.
Smith, R. P. (1991). Chemicals reacting with various forms of hemoglobin:
Biological significance, mechanisms and determination. J. Forensic Sci.
31:662-672.
Smith, R. P., C. A. Louis, R. Kruszyna and H. Kruszyna (1991). Acute
neurotoxicity of sodium azide and nitric oxide. Fund. Appl. Toxicol. 17:120-127.
Wang, Q., J. Jacobs, J. DeLeo, H. Kruszyna, R. Kruszyna, R. Smith and D.
Wilcox (1991). Nitric oxide hemoglobin in mice and rats in endotoxic shock.
Pharmacol. Lett. 49:PL55-PL60.
Huot, A. E., H. Kruszyna, R. Kruszyna, R. P. Smith and M. P. Hacker (1992).
Formation of nitric oxide hemoglobin in erythrocytes co-cultured with alveolar
macrophages taken from bleomycin treated rats. Biochem. Biophys. Res.
Comm. 182:151-157.
Wheeler, M. G., A. A. Rozycki and R. P. Smith. (1992). Recreational propane
inhalation in an adolescent male. J. Toxicol. - Clin. Toxicol. 30:135-139.
Ou, L. C., J. Chen, E. Fiore, J. C. Leiter, T. Brinck-Johnsen, G. F. Birchard, G.
Clemons and R. P. Smith (1992). Ventilatory and hematopoietic responses to
chronic hypoxia in two rat strains. J. Appl. Physiol. 72:2354-2364.
Cantilena, L. R., R. P. Smith, S. Frasur, H. Kruszyna, R. Kruszyna and D. E.
Wilcox (1992). Nitric oxide hemoglobin in patients receiving nitroglycerin and
failure to observe endogenous basal levels. J. Lab. Clin. Med. 120:902-907.
Accompanied by an editorial: Marks, G. S. A sophisticated technique for
measurement of nitric oxide: Implications for the mechanism of action of
nitroglycerin, pp. 826-827.
Conrad, K. P., G. M. Joffe, H. Kruszyna, R. Krusxyna, L. G. Rochelle, R. P.
Smith, J. E. Chavez and M. D. Mosher (1993). Identification of increased nitric
oxide biosynthesis during pregnancy in rats. FASEB J. 7:566-571.
Kruszyna, H., R. Kruszyna, L. G. Rochelle, R. P. Smith and D. E. Wilcox (1993).
Effects of temperature, oxygen, heme ligands and sulfhydryl alkylation on the
reactions of nitroprusside and nitroglycerin with hemoglobin. Biochem.
Pharmacol. 46:95-102.
16
Kruszyna, R., H. Kruszyna and R. P. Smith (1993). A spectrophotometric
method for estimating methemoglobin concentration in the presence of cyanide.
Am. J. Emerg. Med., 11:642-643.
Wang, Y., L. G. Rochelle, H. Kruszyna, R. Kruszyna, R. P. Smith and D. E.
Wilcox (1994). An impurity in some samples of SIN-1 oxidizes it to nitric oxide in
anaerobic solutions. Toxicology 88:165-176.
Ou, L. C., G. L. Sardella, J. C. Leiter, T. Brinck-Johnsen and R. P. Smith (1994).
Role of sex hormones in development of chronic mountain sickness in rats. J.
Appl. Physiol. 77:427-433.
Rochelle, L. G., H. Kruszyna, R. Kruszyna, A. Barchowsky, D. E. Wilcox and R.
P. Smith (1994). Bioactivation of nitroprusside by porcine endothelial cells.
Toxicol. Appl. Pharmacol. 128:123-128.
Smith, R. P., and D. E. Wilcox (1994). Toxicology of selected nitric oxidedonating xenobiotics with particular reference to azide. Crit. Rev. Toxicol.
24:355-377.
Wilcox, D. E., and R. P. Smith (1995). Detection and quantification of nitric oxide
using electron magnetic resonance spectroscopy. Methods 7:59-70.
Rochelle, L. G., S. J. Morana, H. Kruszyna, M. A. Russell, D. E. Wilcox and R. P.
Smith (1995). Interactions between hydroxocobalamin and NO: Evidence for a
redox reaction between NO and reduced cobalamin and reversible NO binding to
oxidized cobalamin. J. Pharmacol. Exp. Ther. 275:48-52.
Currie, J. L., L. A. Mott, S. C. Pennisi, B. D. Smith and R. P. Smith (1997).
Potential for an external vaginal anti-itch cream containing benzocaine to cause
methemoglobinemia in healthy females. Am. J. Obstet. Gynecol. 176:10061008.
Kruszyna, R., R. P. Smith and H. Kruszyna (1998). Determining sodium azide
concentration in blood by ion chromatography. J. Forensic Sci. 43:192-194.
Kruszyna, H., J. S. Magyar, L. G. Rochelle, M. A. Russell, R. P. Smith and D. E.
Wilcox (1998). Spectroscopic studies of nitric oxide interactions with cobalamin:
Reaction of NO with superoxocobalamin(III) likely accounts for cobalamin
reversal of the biological effects of NO. J. Pharmacol. Exp. Ther. 285:665-671.
Kam, H. Y., L. C. Ou, C. D. Thron, R. P. Smith and J. C. Leiter (1999). Role of
the spleen in the exaggerated polycythemic response to hypoxia in chronic
mountain sickness in rats.J. Appl. Physiol. 87:1901-1908.
Miscellaneous:
17
Smith, R. P. (1980). Profile of a department, Pharmacology and Toxicology.
Dartmouth Medical School Alumni Magazine, Spring, 15-18 and 36.
Smith, R. P., and J. M. Barrington (1981). Unit 1. The biochemistry,
pharmacology and toxicology of alcohols. In Alcohol Use and Its Medical
Consequences (H. L. Bonkowsky, Ed.) Milner-Fenwick, Inc., Timonium, NJ.
Smith, R. P. (1991). Desperately seeking sulfide. Dartmouth Med. 15:No. 4,
34-37.
Smith, R. P. (1991) Cyanide poisoning. Audio Digest, Emergency Med. 8:No.
21, Nov. 4.
Smith, R. P. and R. E. Gosselin (1991). Herbert L. Borison. Pharmacologist
33:No. 1,21-22. (Obituary)
Smith, R. P. (1994). The research funding culture. Dartmouth Med. 18:No. 3,
18.
Smith, R. P., and J. M. Barrington (1994). Unit 1. The biochemistry,
pharmacology and toxicology of alcohols, 2nd ed. In Alcohol Use and Its
Medical Consequences (H. L. Bonkowsky, Ed.) Milner-Fenwick, Inc., Timonium,
NJ.
Smith, R. P. (1995). Nonsteroidal anti-inflammatory drugs (NSAID) that release
nitric oxide (NO). InflammoPharmacology 3:195-196 (Invited editorial)
Smith, R. P. (1997). Editorial commentary—Sulfide poisoning. J. Toxicol. Clin. Toxicol.
35:305-306 (Invited editorial)
Gosselin, R. E., and R. P. Smith (1998). Gilbert Horton Mudge (1915-1996).
Pharmacologist 40:No. 2, 42-43. (Obituary)
Smith, R. P. (1999). A lifetime in the lab looking at the "pigments of life". Dartmouth
Medicine 23:No. 3, pp. 8-9.
Smith, R. P. (1999). Escargots, anyone? Humble snail solves respiration puzzle.
Dartmouth Medicine 23:No. 4, pp. 11-12.
Smiith, R. P. (1999). Bill Roebuck: The three musketeers and their China connection.
Dartmouth Medicine 23:No. 4, pp. 50-51 and 56.
Smith, R. P. (1999). Studies in mice may help alleviate human protein malnutrition.
Dartmouth Medicine 24:No. 1, pp. 11-12.
Smith, R. P. (1999). Bob Gosselin: The Art and the Science. DMS Alumni News
18
and No
Smith, R. P. (1999). Physiologist North: Exploring the many faces of vasopressin.
Dartmouth Medicine 24:No. 2, pp. 8-9.
Smith, R. P. (2000). Walter Frey: A man of many hats. DMS Alumni News
and No
Smith, R. P. (2000). Poisonings. http://www.dartmouth.edu/~rpsmith/Contents.html.
Smith, R. P. (2000). Cover-worthy cells attack cancer via a novel mechanism. Dartmouth
Medicine 24:No.3, p. 6.
Smith, R. P. (2000). The admissions cycle: Will it be yes? Or no? Or an agonizing maybe?
Dartmouth Medicine 24:No.3, p. 8-10.
Smith, R. P. (2000). Vergil Ferm: Enjoying endless Saturdays. DMS Alumni News
and No
Smith, R.P. (2000). Resonating tattoos interest radiology researcher Swartz. Dartmouth
Medicine 24:No. 4, pp. 8-9.
Smith, R. P. (2000). What makes my baby blue? Dartmouth Medicine 24:No. 4, pp. 26-31
and 51.
Smith, R. P. (2000). ILEAD: 10 Years Down The Road to Lifelong Education.
Norwich Turns Out for ILEAD and ILEAD and Dartmouth: Partners in Continuing
Education. Norwich Times Fall:pp. 18,19 and 22.
Smith, R. (2000). ILEAD, now in its 10th year, offers continuing liberal education.
VOX of Dartmouth XIX:No. 6, 18 Sept., p. 3.
Smith, R. (2000). Jack Hoopes: Adventures of a veterinary pathologist. Dartmouth
Medicine 25:No. 1, p. 60-2.
Smith, R. P. (2000). Robert Charman: Heeeere's Dr. Bob! DMS Alumni News
and No
Smith, R. P. (2000). DMS and Thayer team up to test new imaging methods. Dartmouth
Medicine 25:No. 2, p. 15-16.
Smith, R. P. (2001). Arsenic: A Murderous History.
http://www.dartmouth.edu/~toxmetal/TXSHas.htm.
Smith, R. P. (2001). Fran and Bob Nye: Two of a kind DMS Alumni News
Smith, R. P. (2001). Biochemist explores mysteries of mitosis and motor proteins.
Dartmouth Medicine 25:No. 3, pp. 15-16.
Smith, R. P. (2001). The origins and rebirth of chautauqua.Norwich Times . Summer:pp.
26-27.
19
and No
Smith, R. P. (2001). Biochemist Barlowe studies intracellular protein trafficking. Dartmouth
Medicine 25:14-15.
Smith, R. P. (2001). Community “classrooms”. Dartmouth Medicine 25:34-41.
Smith, R. P. (2001). Pharm-Tox recruits join translational research team. Dartmouth
Medicine 26:No. 1, pp. 10-11.
Smith, R. P. (2001). Judy Tyson: The unconventionalist. DMS Alumni News
Smith, R. P. (2001). NIH funds Center of Biomedical Research Excellence at DMS.
Dartmouth Medicine 26:No. 2, pp. 9-10.
Smith, R. P. (2002). Gibbons Cornwell: Top gun (with computers). DMS Alumni New and
Notes 5:No. 2, pp. 6,7,31
Smith, R. P. (2002). The Desktop Guide to Complementary and Alternative Medicine: An
Evidence-Based Approach. Ann. Intern. Med. 136:176. (Book review)
Smith, R. P. (2002). Green is appointed to chair microbiology and immunology.
Dartmouth Medicine 26:No. 3, pp. 11-12.
Smith, R. P. (2002). Kandace Williams, Ph.D. ’87: “North to Alaska”. Dartmouth Medicine
25:No. 3, pp. 60,61,63.
Smith, R. P. (2002). Heinz Valtin: A real “old-timer”. DMS Alumni News and Notes 5:No.
3, pp. 5,8.
Smith, R. P. (2002). James Bell: Pied piper of teaching. Dartmouth Medicine 26:No. 4, pp.
54-55.
Smith, R. P. (2002). Let’s sit down together and talk about your problem. Dartmouth
Medicine 27:No. 1, pp. 18-20.
Smith, R. P. (2002). Virtual fellowship teaches genetics via CD or the Web. Dartmouth
Medicine 27:No. 2, pp. 5-6.
Smith, R. P. (2003). Walter Griggs: “Captains Courageous”. DMS Alumni News and Notes
6:No. 2, pp. 2,4
Smith, R. P. (2003). Study explores how students’ attitudes evolve. Dartmouth
Medicine 27:No. 3, pp. 13-14.
Smith, R. P. (2003). Maurice Kelley: King of the road. DMS Alumni News and Notes 6:No.
3, pp. 6-7.
Smith, R. P. (2003). Affordable housing, ‘50s style. Here in Hanover 6:Nol. 3, pp. 16-20.
20
and No
Smith, R. P. (2003). Probing structure of every protein in a massive job. Dartmouth
Medicine 27:No. 4, pp.20.
Smith, R. P. (2003). Together is better than alone, finds DMS-Thayer team. Dartmouth
Medicine 27:No. 4, pp.20-1.
Smith, R. P. (2003). Counterterrorism training for first-responders. . Dartmouth Medicine
28:No. 1, pp. 15 and 17.
Smith, R. P. (2004). Randolph Noelle: Immunology insight has promising applications.
Dartmouth Medicine 28:No. 1, pp. 4-5.
Smith, R. P. (2004). Operation. Dartmouth Medicine 28:No. 1, pp. 44-47.
Smith, R. P. (2004). O. Ross McIntyre: Amazing Grace. DMS Alumni News and Notes
7:No. 2, pp. 12-13.
Smith, R. P. (2004). E. Lucile Smith. DMS Alumni News and Notes 7:No. 2, pp. 38-39.
Smith, R. P. (2004). Dartmouth/ILEAD Pioneer Remembered. ILEAD Newsletter,
Winter/Spring.
Smith, R. P. (2004). Aerial Exotica: Orchids in the Sky. Here in Hanover 7:No. 1, pp. 2226.
Smith, R. P. (2004). Combo of two agents shows promise against colorectal cancer.
Dartmouth Medicine 28:No. 3, pp. 10-11.
Smith, R. P. (2004). John Baron, M. D.The A-B-Cs of preventing cancer. Dartmouth
Medicine 28:No. 3, pp. 58-59.
Smith, R. P. (2004). Don Helms: Putting his best foot forward. DMS Alumni News and
Notes 7:No. 3, pp. 4 and 39.
Smith, R. P. (2004). A One-Woman, One-Day-a-Year Philanthropy. Here in Hanover
7:No. 3, pp. 8-9.
Smith, R. P. (2004). Take a Journey of Learning with ILEAD. Notes to Neighbors
Newsletter, Fall 2004.
Smith, R. P. (2004). Planning for the Vermont of Tomorrow. Woodstock Magazine 4:No.
2, pp. 36-39, 43.
Smith, R. P. (2004). Palladium coils show promise in treating cancer of the prostate.
Dartmouth Medicine 29:No. 1, pp. 9-10.
21
Smith. R. P. (2004). Dartmouth Medical School's "Greatest Generation". DMS News and
Notes. 8:No. 1, pp. 8-9.
Smith, R. P. (2004). His eye's on microvilli. Dartmouth Medicine 29:No. 2, pp. 10.
Smith, R. P. (2005). Rob Chapman: Psychiatric circuit rider. DMS News and Notes. 8:No.
2, pp. 8-9.
Smith, R. P. (2005). FLIPing Out. Here in Hanover 8:No. 1, pp. 26-30.
Smith, R. P. (2005). Study finds new benefits from mammography. Dartmouth Medicine
29:No. 3, p. 3.
Smith, R. P. (2005). John Lyons: Cirujano hispanohablaante. DMS News and Notes.
8:No. 3, pp. 9 and 13.
Smith, R. P. (2005). “A time to be born, and a time to die”. Dartmouth Medicine 29:No. 4,
p. 10.
Buell, C. and R. P. Smith (2005). Eleazar's Other Institution: The Church of
Christ at Dartmouth College. Here in Hanover 8:No. 3, pp.14-16.
Smith, R. P. (2005). Bon (hyroxyl)apatite.Dartmouth Medicine 30:No. 1, p. 9.
Smith, R. P. (2006). DMS’s North stars as mentor for women. Dartmouth Medicine 30:No.
2, p. 22.
Smith, R. P. (2006). Dean Seibert, M. D., First aid. Dartmouth Medicine 30:No. 2, p. 6265. (Reproduced in The Albany Medical College Alumni Bulletin 69:No. 2, pp. 6-8.)
Smith, R. P. (2006). Francis Friedman: The feisty one. DMS News and Notes. 9:No. 2, pp.
8-9.
Smith, R. P. (2006). Diabetes: Progress against complications. Dartmouth Medicine
30:No. 3, p. 4.
Wheelock, S. E. and Smith, R. P. (2006). Wild greens. Dartmouth Medicine 30:No. 3, p.
46-51.
Smith, R. P. (2006). Allan Munck: An engineer gone glucocorticoidal. DMS News and
Notes. 9:No. 3, pp. 4 and 11.
Smith, R. P. (2006). Bad things come in small packages, too. Dartmouth Medicine 30:No.
4, p. 4.
4Smith. R. P. and N. Jacobs. (2006) The sick shriners. Dartmouth Medicine 30:No. 4, p.
44-49.
22
Smith. R. (2006). Use It Up, Wear It Out, Make It Do. Upper Valley Life 1:No. 3, p. 41.
Smith, R. (2006). Park ‘n Bark Coming to the Upper Valley. Upper Valley Life 1:No. 3, p.
42.
Smith. R. (2006). Personal Service? Don’t Bank on It. Backtalk,Valley News, July 30, p.
A9.
Smith, R. P. (2006). PAWS to Read. Upper Valley Life 1:No. 4, p. 50-51.
Smith, R. P. (2006). Ding, dong, dell, arsenic in the well. Dartmouth Medicine 31:No. 1, p.
7.
Smith, R. P. (2006). Keeping Current with Solid Waste Disposal. Here in Hanover 9:No. 3,
p. 22-27.
Smith, R. P. (2006). Ellis Rolett: The Russia connection. DMS News and Notes. 10:No. 1,
pp. 7-8.
Smith, R. P. (2006). Striking the Right Chord. Upper Valley Life 1:No. 5, p. 17.
Smith, R. P. (2006). A Christmas Market with a Difference. Upper Valley Life 1:No. 5, p.
19-20.
Smith, R. P. (2006). Robotics: Maximally Cool. Upper Valley Life 1:No. 5, p. 45-46.
Smith, R. P. (2006). Dartmouth fosters birth and rebirth in Kosovo. Dartmouth Medicine
31:No. 2, p. 18.
Smith, R. P. (2007). Alex Reeves: High-voltage neurologist. DMS News and Notes. 10:No.
2, pp. 7 and 47.
Smith, R. P. (2007). Business Advice: SCORE or Tuck Student Consulting Service.
http://www.uppervalleylife.com/online/.
Smith, R. P. (2007). Not Just Any Old Port in a Storm, A Profile of Port Expert Isaac
Oelgart. http://www.uppervalleylife.com/online/.
Smith, R. P. (2007). Barbara Payson: Paging Dr. Mom. DMS News and Notes 10: No. 3,
pp. 4 and 43.
Abstracts, Letters, Book Reviews
Smith, R. P. (1961). A poison information center for American armed forces in
Europe. Bull. Natl. Clearinghouse Poison Control Centers, Jan.-Feb.
23
Smith, R. P. (1961). What do medical students learn about drugs? Am. Prof.
Pharm. 27:No. 9, 30-31.
Smith, R. P., and R. E. Gosselin (1963). Protective capacity of
methemoglobinemia in sulfide poisoning. Fed. Proc. 22:310.
Smith, R. P., and R. E. Gosselin (1964). On the mechanism of sulfide
inactivation by methemoglobin. Fed. Proc. 23:297
Smith, R. P., and R. E. Gosselin (1964). Protective capacity of
methemoglobinemia in sulfide poisoning. Bull. Natl. Clearinghouse Poison
Control Centers, Jan.-Feb.
Gosselin, R. E., and R. P. Smith (1965). Theoretical aspects of hemodialysis.
Bull. Natl. Clearinghouse Poison Control Centers, Jan.-Feb.
Vaughan, M. C., R. E. Gosselin and R. P. Smith (1965). Effects of oxygen on
the determination of thiocholine by DTNB. Fed. Proc. 24:610.
Stolk, J. M., and R. P. Smith (1965). Species variations in methemoglobin
reductase activity. Pharmacologist 7:150.
Smith, R. P. (1966). Drugs in Our Society. Bull. History Med. 40:96-97. (Book
review)
Smith, R. P., and R. A. Abbanat (1966). Protective effects of oxidized
glutathione in acute sulfide poisoning. Fed. Proc. 25:688.
Smith, R. P. (1967). Methemoglobin reductases in sulfide poisoning. Fed. Proc.
26:650.
Klurfeld, G., and R. P. Smith (1967). Chloride inhibition of methemoglobin
reduction in mouse red cells. Pharmacologist 9:206.
Layne, W. R., and R. P. Smith (1968). Effects of methylene blue on nitrite and
hydroxylamine methemoglobinemias. Fed. Proc. 27:466.
Smith, R. P. (1969). Effects of cobalt salts in cyanide and sulfide poisonings and
on methemoglobinemia. Toxicol. Appl. Pharmacol. 14:629.
Smith, R. P., and J. T. Russell (1969). A hemoglobin variant induced by
methylene blue and low oxygen tensions. Fed. Proc. 28:479.
Smith, R. P., and C. D. Thron (1969). Methemoglobin formation by methylene
blue. Pharmacologist 11:282.
24
Bolyai, J. Z., R. P. Smith and C. T. Gray (1971). Ascorbic acid and chemicallyinduced methemoglobinemias. Fed. Proc. 30:221.
Cranston, R. D., and R. P. Smith (1971). Some aspects of the reactions
between hydroxylamine and hemoglobin derivatives. Toxicol. Appl. Pharmacol.
19:401.
Felsenstein, W. C., R. P. Smith and R. E. Gosselin (1971). Methemoglobinforming properties of the avicide, 3-chloro-p-toluidine. Pharmacologist 13:241.
Smith, R. P. (1973). Cyanate and thiocyanate: Acute toxicity. Toxicol. Appl.
Pharmacol. 25:477.
Smith, R. P. (1973). Toxicology of sodium nitroferricyanide. Pharmacologist
15:227.
Smith, R. P. (1974). Toxicological studies on the avicide, 3-chloro-p-toluidine.
Toxicol. Appl. Pharmacol. 29:135.
Smith, R. P. (1975). Standardization of methemoglobin analyses with nitrite.
Clin. Chem. 21:269-270. (Letter)
Smith, R. P., and H. Kruszyna (1975). Use and toxicity of nitroprusside. N. Engl.
J. Med. 292:1081. (Letter)
Smith, R. P., R. E. Gosselin and R. Kruszyna (1975). Sodium azide poisoning.
Ann. Intern. Med. 83:739. (Letter)
Smith, R. P., and L. C. Ou (1975). Methaemoglobinemia at high altitude. Br. J.
Haematol. 31:411-412. (Letter)
Smith, R. P. (1976). Drug-induced Blood Disorders. N. Engl. J. Med. 294:62.
(Book review)
Smith, R. P., and R. A. Carleton (1976). Nitroprusside and methemoglobinemia.
N. Engl. J. Med. 294:502-503. (Letter)
Ou, L. C., and R. P. Smith (1976). Intravascular hemolysis in rats maintained at
high altitude. Fed. Proc. 35:238.
Smith, R. P., and H. Kruszyna (1976). Nitroprusside and cyanide. Br. J.
Anaesthesia 48:396. (Letter)
Smith, R. P., and H. Kruszyna (1977). Nitroprusside and cyanide. Br. J.
Anaesthesia 49:395. (Letter)
25
Smith, R. P., R. Kruszyna and L. C. Ou (1977). Sex differences in the response
of mice to high altitude. Pharmacologist 19:180.
Smith, R. P. (1978). Hydrogen sulfide poisoning. Can. Med. Assoc. J. 118:775776. (Letter)
Smith, R. P. (1978). Nitroprusside and vascular resistance. Can. Anaesth. Soc.
J. 25:338. (Letter)
Kruszyna, H., and R. P. Smith (1978). Sodium nitroprusside and liberation of
cyanide. Br. J. Anaesth. 50:1169. (Letter)
Smith, R. P., H. Kruszyna and J. H. Hurst (1979). Acute toxicity of ruthenium
salts and complexes. Toxicol. Appl. Pharmacol. 48:A112.
Willhite, C. C., R. P. Smith and L. Smith (1979). The effect of aliphatic nitriles on
in vitro cytochrome c oxidase activity and the effect of cyanide antagonists on
acute nitrile toxicity. Pharmacologist 21:187.
Willhite, C. C., V. H. Ferm, M. Marin-Padilla and R. P. Smith (1980).
Developmental malformations induced by metabolically-liberated cyanide.
Toxicol. Appl. Pharmacol. A88.
Smith, R. P., and R. A. Adler (1980). Hazards of urine reagent and preservative
tablets. Vet. Hum. Toxicol. 22:120-121. (Letter)
Smith, R. P., R. Kruszyna and H. Kruszyna (1981). Cyanide reverses
nitroprusside relaxation of rabbit aortic strips and decreases c-GMP content.
Fed. Proc. 40:690.
Doherty, P. A., V. H. Ferm and R. P. Smith (1981). Cyanide teratogenicity in the
Syrian golden hamster (SGH). Pharmacologist 23:214.
Smith, R. P. (1981). Nitrite treatment for hydrogen sulfide poisoning. Ann.
Intern. Med. 95:782. (Letter)
Doherty, P. A., R. P. Smith and V. H. Ferm (1982). Comparison of the acute
toxicity of tetramethylsuccinonitrile (TMSN) and succinonitrile (SN). Toxicologist
2:142-143.
Ou, L. C., and R. P. Smith (l982). Strain differences in the susceptibility to
chronic high altitude exposure in rats. Fed. Proc. 41:1618.
Kaplita, P. V., H. L. Borison and R. P. Smith (1982). Cardiovascular and
respiratory actions of sodium nitroprusside in the anesthetized cat.
Pharmacologist 24:165.
26
Schwerin, F., R. Rosenstein and R. P. Smith (1982). Reversal by sodium
cyanide (CN-) of sodium nitroprusside (SNP) induced inhibition of platelet
aggregation. Pharmacologist 24:194.
Ou, L. C., H. Y. Cam and R. P. Smith (1982). Splenic and medullary
erythropoiesis in response to high altitude exposure in rats. I. Radio-iron uptake
study. Exp. Hematol. 10:Supple. 11:150.
Kam, H. Y., L. C. Ou and R. P. Smith (1982). Splenic and medullary
erythropoiesis in response to high altitude exposure in rats. II. Morphological
studies on formed elements. Exp. Hematol. 10:Supple. 11:150.
Smith, R. P., H. Kruszyna and R. Kruszyna (1982). Cyanide release from
nitroprusside. Br. J. Anaesth. 54:1145-1146. (Letter)
Doherty, P. A., R. P. Smith and V. H. Ferm (1983). Comparison of the
teratogenic effects of succinonitrile (SN) and tetramethylsuccinonitrile (TMSN) in
the Syrian golden hamster (SGH). Toxicologist 3:30.
Ou, L. C., and R. P. Smith (1983). Cardiopulmonary responses of susceptible
and resistant strains of rats exposed to hypoxia. Clin. Res. 31:211A.
Smith, R. P., R. Kruszyna and H. Kruszyna (1983). Antagonism of nitroprusside
effects by cyanide may not be clinically relevant: In reply. Anesthesiology
59:159-161. (Letter)
Rutkowski, J. V., B. D. Roebuck and R. P. Smith (1983). Is hepatic rhodanese
important for the detoxication of acutely administered NaCN in mice?
Pharmacologist 25:273.
Cai, Y. N., L. C. Ou and R. P. Smith (1984). Severe polycythemia and
hypervolemia in a rat model of chronic mountain sickness (CMS). Fed. Proc.
43:905.
Smith, R. P., H. Kruszyna, R. Kruszyna and R. Rosenstein (1984). Cyanide (CN)
reverses the effects of some nitrogen hydrides and oxides in a variety of
biological systems. Abstracts of the 9th International Congress of
Pharmacology, London. The Macmillan Press, No. 563.
Mulligan, C., G. L. Sardella, L. C. Ou, T. Brinck-Johnson and R. P. Smith (1984).
Do sex hormones account for the male (M)-female (F) differences in the
susceptibility of rats to chronic hypoxia? Physiologist 27:251.
Smith, R. P. (1985). A response to a letter on the treatment of cyanide
poisoning. Vet. Hum. Toxicol. 27:110. (Letter)
27
Kaplita, P. V., and R. P. Smith (1985). Alcohol dehydrogenase (ADH) inhibitors
and dimethylsulfoxide (DMSO) prevent the acute toxicity of aliphatic nitriles.
Pharmacologist 27:252.
Smith, R. P., R. Kruszyna and H. Kruszyna (1985). Preparation of a hemoglobin
valency hybrid in high yield which does not bind O2. Pharmacologist 27:286.
Devlin, D. J., and R. P. Smith (1987). Cyanide (KCN) metabolism in the isolated
perfused hindlimbs and liver of the rat. Fed. Proc. 46:954.
Smith, R. P., R. Kruszyna, H. Kruszyna and D. E. Wilcox (1987). Chemicallyinduced valency hybrid (VH) species of hemoglobin in mice: Quantification, time
course, nitrosylation. Pharmacologist 29:185.
Smith, R. P. (1988). Clinical pharmacology instruction during medical school.
Pharmacologist 30:38-39.
Smith, R. P., D. E. Wilcox, H. Kruszyna and R. Kruszyna (1989). Cyanide (CN)
inhibits the formation of nitrosylhemoglobin (HbNO) from deoxyhemoglobin and
sodium nitroprusside (SNP). Toxicologist 9:289.
Smith, R. P., H. Kruszyna, R. Kruszyna and D. E. Wilcox (1989). Generation of
valency hybrid (VH) and nitrosylated species of hemoglobin (H) in human red
blood cells (RBC) and in mice by nitric oxide (NO) vasodilators. In Vascular
Endothelium, Receptors and Transduction Mechanisms, (J. D. Catravas, C. N.
Gillis and U. S. Ryan) NATO ASI Series A: Life Sciences, Vol. 175.
Sana, T. R., V. H. Ferm and R. P. Smith (1990). Sodium azide (NaN3) has weak
teratogenic effects in the golden hamster. Toxicologist 10:124.
Smith, R. P., C. A. Louis, R. Kruszyna and H. Kruszyna (1990). Acute
neurotoxicity of sodium azide and nitric oxide. Pharmacologist 32:161.
Chen, J., T. Brinck-Johnsen, R. Smith and L. C. Ou (1990). Lowered hypoxic
threshold for erythropoietin (EPO) production in rats with chronic mountain
sickness (CMS). Physiologist 33: A-49.
Ou, L. C., J. Chen, T. Brinck-Johnsen and R. Smith (1990). Effects of anemic
hypoxia on erythropoietic activity in two strains of rats. Physiologist 33: A-49.
Smith, R. P. and C. C. Willhite (1991). Effects of oxychlorines on red blod cells
(RBC): General population vs. dialysis patients. Proc. Chlorine Dioxide
Workshop, USEPA, AWWARF and CMA, Denver, CO, 1989.
Wang, Q., J. M. Jacobs, J. A. DeLeo, H. Kruszyna, R. Kruszyna, R. P. Smith and
D. E. Wilcox (1991). Endotoxic shock and nitric oxide hemoglobin (HbNO)
formation in mice and rats. Pharmacologist 33:147.
28
Smith, R. P., L. G. Rochelle, R. Kruszyna and H. Kruszyna (1992). Nitroprusside
is not a substrate for cytochrome P450 in mice. FASEB J. 6:A1583.
Chen, J., J. Leiter, R. Smith, T. Brinck-Johnsen and L. C. Ou (1992). Hypoxiainduced erythropoietin (EPO) production is independent of renal function.
FASEB J. 6:A1774.
Conrad, K. P., G. M. Joffe, H. Kruszyna, R. Kruszyna, L. G. Rochelle, R. P.
Smith, J. E. Chavez and M. D. Mosher (1992). Identification of increased nitric
oxide biosynthesis during pregnancy in rats. J. Am. Soc. Nephrol. 3:542.
Smith, R. P., L. G. Rochelle, R. Kruszyna and H. Kruszyna (1992). Nitroprusside
is not a substrate for cytochrome P450 in rats or mice. Proc. N. Engl.
Pharmacol. 21st Annual Meeting.
Rochelle, L. G., H. Kruszyna, A. Barchowsky and R. P. Smith (1994).
Bioactivation of nitroprusside (SNP) by endothelial cells. Proc. N. Engl.
Pharmacol., 22nd Annual Meeting.
Rochelle, L. G., H. Kruszyna, A. Barchowsky and R. P. Smith (1994). Activation
of nitroprusside (SNP) by endothelial cells. Toxicologist 14:200.
Smith. R. P. (1997). Too hazardous? J. Am. Pharm. Assoc. NS37:276. (Letter)
Smith, R. P., H. Kruszyna, J. S. Magyar, L. G. Rochelle, M. A. Russell and D. E. Wilcox.
(1998). Reaction of NO with superoxocobalamin(III) likely accounts for cobalamin reversal
of the biological effects of NO. FASEB J. 12:A128.
Magyar, J. S., M. A. Russell, D. E. Wilcox, H. Kruszyna, L. G. Rochelle and R. P. Smith
(1998). Interactions of cobalamin with nitric oxide. Abstracts of the 215th National Meeting
of the American Chemical Society, Dallas, TX, Mar.29-April 2, Abstract #INOR 460.
Smith, R. P. (2000). Teaching kudos. The Purdue Alumnus Jan./Feb., p. 4. (Letter)
Smith, R. P. (2001). Blue in the face. J. Am. Acad. Dermatol. 44:872. (Letter)
Smith, R. P. (2005). Poison in the Well. Venomous Earth: The World's Worst Mass
Poisoning. Nature 433:576. (Book Review)
Smith, R. P. (2005). Chemistry to die for. The Elements of Murder: A History of Poison.
Nature 436:779. (Book Review)
Rev. 05/09/07
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