Taiwan-ACGA 2010
International Conference on Genetic and Genomic Medicine
May 2-5, 2010
Academia Sinica, Taipei, Taiwan
Program
May 2 (Sunday)
4:30 – 6:30 pm Registration [3F]
6:30 – 8:00 pm Welcome Reception
[4F, Recreation Hall]
May 3 (Monday)
8:45 – 9:00 am Opening Remarks
[3F, International Conference Hall]
Stephen T.S. Lam, President, Association of Chinese Geneticists in America
Yuan-Tsong Chen, Chairman, Taiwan-ACGA 2010 Organizing Committee
9:00 – 10:00 am Keynote Speech I
[3F, International Conference Hall]
Moderator: Pan-Chyr Yang, President, Taiwan Genomics and Genetics
Society
Mark I McCarthy, University of Oxford, UK
Type 2 Diabetes genetics: the end of the beginning or the beginning of the
end
10: 00 – 10:15 am
Coffee Break
10 :15 am – 12 :15 pm Concurrent Session I
C1: Population Genetics [3F, International Conference Hall]
Chairs: Cathy S.J. Fan, Academia Sinica, Taiwan
Nelson L.S. Tang, Chinese University of Hong Kong, Hong Kong
10:15 – 10:45 am
Cathy S.J. Fan, Academia Sinica, Taiwan
Modeling expression quantitative trait loci in data combining ethnic
populations
10:45 – 11:15 am
Nelson L.S. Tang , Chinese University of Hong Kong, Hong Kong
Population genetics of gene expression and disease causing mutations
11:15 – 11:45 am
Li Jin, Fudan University, China
Identification of Copy Number Variation Hotspots in Human Populations
11:45 am – 12:15 pm
Pei-Lung Chen, National Taiwan University Hospital, Taiwan
Graves’ disease is associated with a distinct spectrum of HLA alleles in
Asian populations
C2: Clinical Genetics
[3F, 2nd Conference Room]
Chairs: Paul Wuh-Liang Hwu, National Taiwan University Hospital, Taiwan
Stephen T.S. Lam, Department of Health, Hong Kong
10:15 – 10:45 am
Marie T. Vanier, National Institute of Health and Medical Research, France
Lysosomal Storage Disorders: complementary role of biochemistry and
molecular genetics in laboratory diagnosis and management of patients and
families
10:45 – 11:15 am
Lee-Jun C. Wong, Baylor College of Medicine, USA
Diseases Involved in Loss of Mitochondrial DNA Integrity
11:15 – 11:45 am
Stephen T.S. Lam, Department of Health, Hong Kong
Studies of Multiple Malformations in Chinese
11:45 am – 12:15 pm
12:20 – 1:30 pm
Margherita Milone, Mayo Clinic College of Medicine, USA
Congenital myasthenic syndromes: from patient to bench and back
Company Sponsored Seminar I
Excelsior Biopharma Inc. [3F, Reception Room]
Genzyme Taiwan
[4F, Recreation Hall]
Genzyme's application of Genetic analysis in understanding our patient
populations
Robert J. Pomponio, Clinical Laboratory Science, Genzyme Corporation
1:40 – 2:40 pm
Keynote Speech II [3F, International Conference Hall]
Moderator: Stephen Lam, President, Association of Chinese Geneticists
in America
David W. Russell, University of Washington, USA
Engineering of Human Pluripotent Stem Cells by AAV-Mediated Gene
Targeting
2:40 – 3:00 pm
Coffee Break
3:00 – 5:00 pm Concurrent Session II
C3: Genetic Therapeutics
[3F, 2nd Conference Room]
Chairs: Mi-Hua Tao, Academia Sinica, Taiwan
Weidong Xiao, Temple University, USA
3:00 – 3:30 pm Weidong Xiao, Temple University, USA
Pathways toward Gene Therapy for Hemophilia using recombinant AAV
vectors
3:30 – 4:00 pm Arun Srivastava, University of Florida, USA
Novel AAV vectors and strategies for the potential gene therapy of
hemophilia A and hemophilia B
4:00 – 4:30 pm Mi-Hua Tao, Academia Sinica, Taiwan
Use of RNA Interference to Modulate Liver Adenoma Development in a
Murine Model Transgenic for Hepatitis B Virus
4:30 – 4:45 pm Yudan Fan, Shanghai Jiao Tong University, China
**
-hemoglobin stabilizing protein could partially relieve
IVS-2-654-thalassemia syndrome in model mice
4:45 – 5:00 pm DarShong Lin, Mackay Memorial Hospital, Taiwan
**Efficient Axonal Transport-Based Gene Delivery Provides Therapeutic
Correction in Murine Globoid Cell Leukodystrophy
C4: Prenatal and Pre-implantation Diagnosis & Screening
[3F, International Conference Hall]
Chairs: Hong-Nerng Ho, National Taiwan University Hospital, Taiwan
Taosheng Huang, University of California, Irvine, USA
3:00 – 3:30 pm Taosheng Huang, University of California, Irvine, USA
Advancement of prenatal screening and prenatal diagnosis in USA (#18)
3:30 – 4:00 pm Richard Choy, Prince of Wales Hospital, Hong Kong
Molecular Karyotyping by array CGH in uncultured CVS: a new horizon for
prenatal Diagnosis
4:00 – 4:30 pm Yi-Ning Su, National Taiwan University, Taiwan
Prenatal and Pre-implantation Diagnosis & Screening in Taiwan
4:30 – 5:00 pm Ming Chen, Changhua Christian Hospital, Taiwan
Genetic Perspective of Fetal Medicine: Using Fetal Hydrothorax as an
Example
May 4 (Tuesday)
9:00-10:00 am
Keynote Speech III
[3F, International Conference Hall]
Moderator: Yuan-Tsong Chen, President, Taiwan Human Genetics Society
David B. Goldstein, Duke University, USA
Rare and common variants in human disease and drug response
10:00 – 10:15 am
Coffee Break
10:15 am – 12:15 pm Concurrent Session III
C5: Pharmacogenetics
[3F, International Conference Hall]
Chairs: Yuan-Tsong Chen, Academia Sinica, Taiwan
David B. Goldstein, Duke University, USA
10:15 – 10:45 am
Jin-ding Huang, National Cheng Kung University., Taiwan
CYP3A5 genotypes affect pharmacokinetics of nifedipine differently in
different gender and dosage forms
10:45 – 11:15 am
Wen-Hung Chung, Chang Gung Memorial Hospital, Taiwan
The genotype-phenotype relationship of severe cutaneous adverse drug
reactions
11:15 – 11:45 am
Michael A. Wagner, Indiana University School of Medicine, USA
From Personalized Medicine to Personalized Justice: A complicated road
map to interpretation and application of Pharmacogenomics in the Justice
System
11:45 – 12:00 am
Chun-yu Wei, National Yang-Ming University, Taiwan
**The role of HLA-B*1502 in carbamazepine-induced Stevens-Johnson
syndrome
12:00 am – 12:15 pm Pei Chen, Academia Sinica, Taiwan
**Health Care Savings from Personalizing Medicine of Using genetic
testing to prevent carbamazepine-induced Stevens-Johnson syndrome
and toxic epidermal necrolysis
C6: Medical Genetics
[3F, 2nd Conference Room]
Chairs: Fuu-Jen Tsai, China Medical University, Taiwan
Yao-Shan Fan, University of Miami, USA
10:15 – 10:45 am
Yao-Shan Fan, University of Miami, USA
Genetic testing for personalized cancer treatment
10:45 – 11:15 am
Ni-Chung Lee, National Taiwan University Hospital, Taiwan
Genome-wide Screen for Submicroscopic Chromosomal Aberrations by
High Density Oligonucleotide Array in Children with Unexplained Mental
Retardation and Dysmorphic Features
11:15 – 11:45 am
Tian-Jian Chen, University of South Alabama, USA
Mutation, mosiacism, X-inactivation and sequence variant: Lessons
from unusual molecular findings
11:45 am – 12:15 pm Songbin Fu, Harbin Medical University, China
Molecular structure and differential expression of genes of double minute
chromosomes in UACC-1598 and cooperation of target genes in ovarian
cancer
12:20 – 1:30 pm
Company Sponsored Seminar II
Agilent Technologies Taiwan Ltd. [3F, Front Hallway]
Ming Chen, Changhua Christian Hospital Medical Center, Taiwan
Use of oligonucleotide customized array CGH in clinical genetics:
prenatal and postnatal applications
Cold Spring Biotech Corporation
[4F, Recreation Hall]
1:40 – 3:40 pm
Concurrent Session IV
C7: Molecular Genetics
[3F, 2nd Conference Room]
Chairs: Jian-Wei Chen, National Chung Hsing University, Taiwan
Xue Zhong Liu, University of Miami, USA
1:40 – 2:10 pm
Xue Zhong Liu, University of Miami, USA
The genetic bases for hearing loss among Chinese
2:10 – 2:40 pm
Cynthia Morton, Harvard Medical School, USA
Fortune From Mis-Fortune: Disease Gene Discovery Through Chromosomal
Rearrangements
2:40 – 3:10 pm
Lin He, Chinese Academy of Sciences, China
A century-old story of BDA1
3:10 – 3:40 pm
Huei-Wen Chen, National Taiwan University, Taiwan
Nanotoxicogenomics
C8: Genomic Technologies in the Post Genomic Era [3F, International Conference Hall]
Chairs: Chia-Lin Wei, Genome Institute of Singapore, Singapore
Huanming Yang, Chinese Academy of Sciences, China
1:40 – 2:10 pm
Chia-Lin Wei, Genome Institute of Singapore, Singapore
Dynamic of Genome Organizations and Epigentetic Networks during
Differentiation
2:10 – 2:40 pm
Huanming Yang, Chinese Academy of Sciences, China
The Next Generation Sequencing: Today and Tomorrow
2:40 – 3:10 pm
Yijun Ruan, Genome Institute of Singapore, Singapore
Genome-wide mapping of long-range chromatin interactions involved in
transcription regulation
3:10 – 3:30 pm
Yi-Jung Lin, Academia Sinica, Taiwan
**PrimerZ 4.0: An Online High-Throughput Primer Design Tool for the Next
Generation Sequencing Era
3:40 – 4:00
Coffee Break
4:00 – 6:00 pm
Poster Session
[3F, Side Hallways]
7:00 – 9:00 pm
Banquet
[Peng’s Agora Garden, tickets required]
Buses leave from the front of the Humanities and Social Sciences Building at
6:20 pm
May 5 (Wednesday)
9:00 – 11:00 am
Concurrent Session V
C9: Cancer Genetics and Genomics [3F, International Conference Hall]
Chairs: Pan-Chyr Yang, National Taiwan University, Taiwan
Marilyn Li, Tulane University, USA
9:00 – 9:30 am
Marilyn Li, Tulane University, USA
Clinical Application of Microarray Technology on Hematological Malignancies
and Solid Tumor
9:30 – 10:00 am Chris Lau, University of California, San Francisco, USA
Battle of the Sexes: the Roles of Y-located TSPY and X-located TSPX Genes
in Cell Proliferation, Viral Protein Stability and Tumorigenesis
10:00 – 10:30 am
Yi-Ching Wang, National Cheng Kung University, Taiwan
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1
accumulation and tumor suppressor gene hypermethylation in mice and
lung cancer patients
10:30 – 11:00 am
Ker-Chau Li, Academia Sinica, Taiwan
A study of DNA copy number alternation for lung adenocarcinoma with
EGFR mutation comparison
C10: Complex Disorders [3F, 2nd Conference Room]
Chairs: Pui-Yan Kwok, University of California, San Francisco, USA
Chen-Yang Shen, Academia Sinica, Taiwan
9:00 – 9:30 am
Pui-Yan Kwok, University of California, San Francisco, USA
After GWAS, then what ?
9:30 – 10:00 am Esteban González Burchard, University of California, San Francisco, USA
Integrating Admixture Mapping and SNP Analysis from the largest
Genome-Wide Association Study in U.S. Hispanics: insights from the GALA
study
10:00 – 10:30 am
Wen-Harn Pan, Academia Sinica, Taiwan
Lesson learned from mapping hypertension genes
10:30 – 11:00 am
Zhuohua Zhang, Central South University, Hunan, China
Genetic and Epigenetic Mechanisms of Parkinson’s Disease
11:00 – 11:15 am
Coffee Break
11:15 am – 12:15 pm Keynote Speech IV
[3F, International Conference Hall]
Moderator: Paul Wuh-Liang Hwu, National Taiwan University Hospital,
Taiwan
Arthur Beaudet, Baylor College of Medicine, USA
The impact of chromosomal microarray analysis on medical genetics
12:15 – 12:30 pm
Closing Remarks & Award Presentation
[3F, International
Conference Hall]
Closing Remarks: Yuan-Tsong Chen, Director, Institute of Biomedical Sciences, Academia
Sinica, Taiwan
Award Presentation: Andrew Chen, Executive Director, Association of Chinese Geneticists in
America, USA
Travel Awardees:
Keith E. Szulwach (USA)
Min Pan (China)
Tao Zhang (China)
Abstract Awardees: to be announced.
** Selected from submitted abstracts.