Hong-Bing Shu, PhD
All Publications
1. Nabel EG, Shum L, Pompili V, Yang Z, San H, Shu HB, Lipty S, Gordon D,
Derynck R, and Nabel GJ* (1993). Direct gene transfer of TGF- into artery wall
stimulate fibrocelllular hyperplasia. P Natl Acad Sci USA 90:10759-10763.
2. Shu HB, Agranoff A, Nabel EG, Leung K, Neish AS, Collins , Nabel GJ* (1993).
Differential regulation of VCAM-1 gene expression by specific NF-B subunits in
endothelial and epithelial cells. Mol Cell Biol 13:6283-6289.
3. Shu HB, Li Z, Palacios MJ, Li Q, Joshi HC* (1995). A transient association of tubulin at the midbody is required for the completion of cytokinesis during the
mammalian cell division. J Cell Sci 108: 2955-2962.
4. Shu HB , Joshi HC* (1995). -Tubulin can both neacleate microtubule assembly and
self-assemble into tubular structures in mammalian cells. J Cell Biol 130:1137-1147.
5. Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV* (1996). ITRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal
transduction. P Natl Acad Sci USA 93:8241-8246.
6. Hsu H, Huang J, Shu HB, Baichwal, VR, Goeddel DV* (1996). TNF-dependent
recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.
Immunity 4:387-396.
7. Hsu H, Shu HB, Pan MG, Goeddel DV* (1996). TRADD-TRAF2 and TRADDFADD interactionss define two distinct TNF receptor-1 signal transduction pathways.
Cell 84:299-308.
8. Shu HB, Takeuchi M, Goeddel DV* (1996). The TNF receptor 2 signal transducers
TRAF2 and c-IAP1 are components of the TNF receptor 1 signaling complex. P Natl
Acad Sci USA 93:13973-13978.
9. Shu HB, Halpins DR, Goeddel DV* (1997). Casper is a FADD and Caspase-related
Inducer of Apoptosis. Immunity 6:751-763.
10. Yeh WC, Pompa JL, McCurrach ME, Shu HB, Elia AJ, Shahinian A, Ng M,
Wajegam A, Mithchell K, El-Deiry WS, Lowe SW, Goeddel DV M,ak TW* (1998).
FADD: essential for embryonic development and signaling from some, but not all,
inducers of apoptosis. Science 279:1954-1958.
11. Shu HB, Hu WH, Johnson H (1999). TALL-1 is a novel member of the TNF family
that is downregulated by mitogens. J Leukocyte Biol 65:680-683.
12. Hu WH, Johnson H, Shu HB* (1999). TRAIL signal NFB and JNK activation and
apoptosis through distinct pathways. J Biol Chem 274:30603-30610.
13. Hu WH, Johnson H, Shu HB* (2000). Activation of NFB by FADD, Casper and
Caspase-8. J Biol Chem 275:10838-10844.
14. Shu HB, Johnson H (2000). BCMA is a receptor for the TNF family member
TALL-1. P Natl Acad Sci USA 97:9156-9161.
15. Yeh WC, Itie A, Elia AJ, Ng M, Shu HB, Wakeham, A., Mirtsos, C, Suzuki N,
Bonnard M, Goedde, DV, and Mak TW* (2000). Requirement for Casper (c-FLIP) in
regulation of death receptor-induced apoptosis and embryonic development.
Immunity 12:633-642.
16. Hong X, Xu LG, Li X, Zhai Z, and Shu HB* (2001). CSN3 interacts with IKKand
inhibits TNF- but not IL-1induced NF-B activation. FEBS Lett 499:133-136.
17. Li LY, Shu HB* (2001). Molecular mechanisms of TRAIL-induced apoptosis of
cancer cells. Chinese Sci Bull 46:709-709.
18. Li LY , Hu JC, Bin LH, Li LX, Zha JK, Xu LG, Zhang Z , Zhai ZH , Shu HB *
(2001). Recombinant soluble TRAIL induces apoptosis of cancer cells. Chinese Sci
Bull 46: 2073-2077.
19. Zhou J, Shu HB, Joshi HC* (2002). Regulation of tubulin synthesis and cell cycle
progression in mammalian cells by -tubulin-mediated microtubule nucleation. J
Cell Biochem 84: 472-483.
20. Bin L, Li X, Shu HB* (2002). The short splice form of Casper/c-FLIP is a major
inhibitor of TRAIL-induced apoptosis. FEBS Lett 510:37-40.
21. Chen D, Li X, Zhai Z, Shu HB* (2002). A novel zinc finger protein interacts with
RIP and inhibits TNF- and IL-1-induced NF-B activation. J Biol Chem. 277:1598515991.
22. Liu Y, Xu L, Opalka N, Kappler J, Shu HB, Zhang G* (2002). Crystal structure of
sTALL-1 reveals a virus-like assembly of TNF family ligands. Cell 108: 383-394.
23. Wu M, Xu L, Li X, Zhai Z , Shu HB* (2002). AMID, an AIF homologous
mitochondrion-associated protein, induces caspase-independent apoptosis. J Biol
Chem 277:25617-25623.
24. Xu L, Wu M, Zhai Z , Shu HB* (2002). Identification of genes regulated by the
tumor necrosis factor family member TALL-1. J Leukocyte Biol 72:410-416.
25. Xu L, Shu HB* (2002). TRAF3 is associated with BAFF-R and negatively regulates
BAFF-R-mediated NF-B activation and IL10 production. J Immunol 169: 68836889.
26. Zha JK, Shu HB* (2002). Molecular mechanism of signaling by tumor necrosis
factor. Sci China Ser C 45: 113-119.
27. Liu Y, Hong X, Kappler J, Jiang L, Zhang R, Xu L Pan CH, Martin WE, Murphy RC,
Shu HB, Dai S, and Zhang G* (2003). Ligand-receptor binding revealed by the TNF
family member TALL-1. Nature 423:49-56.
28. Chen D, Xu LG, Chen L, Li L, Zhai Z, and Shu HB* (2003). NIK is a component of
the EGF/Heregulin receptor signaling complex. Oncogene 22:4348-4355.
29. Wu M, Xu L, Zhai Z, Shu HB* (2003). SINK: a p65-interacting protein that
negatively regulates NF-B-dependent transcription. J Biol Chem 278:27072-27079.
30. Bin L, Xu L, Shu HB* (2003). TIRP: a novel TIR domain-containing adapter protein
involved in toll/interleukin-1 receptor signaling. J Biol Chem 27:24526-24532.
31. Bin L, Nielson LD, Liu X, Mason RJ, Shu HB* (2003). Identification of UGRP1 and
MARCO as a lung-specific ligand-receptor pair. J Immunol 171:924-930.
32. Li Z, Zhang J, Chen D, Shu HB* (2003). Casper/c-FLIP is physically and
functionally associated with NF-kB1 p105. Biochem Bioph Res Co 309:980-985.
33. Chen D, Li Z, Yang Q, Zhang J, Zhai Z, Shu HB* (2003). Identification of a nuclear
protein that promotes NF-B activation. Biochem Bioph Res Co 310:720-724.
34. Huang J, Teng L, Liu T, Li L, Chen D, Li F, Xu LG, Zhai Z, Shu HB* (2003).
Identification of a novel serine/threonine kinase that inhibits TNF-induced NFkappaB activation and p53-induced transcription. Biochem Bioph Res Co 309:774778.
35. Hong X, Kappler J , Liu YF, Xu LG, Shu HB, Zhang GY* (2004). TNF ligands: Is
TALL-1 a trimer or a virus-like cluster? Reply. NATURE 427: 414-414.
36. Zhang J, Xu LG, Han KJ, Shu HB* (2004). Identification of a ZU5 and death
domain containing inhibitor of NF-B. J Biol Chem 279:17819-17825.
37. Han KJ, Su X, Xu LG, Bin LH, Zhang J, Shu HB* (2004). Mechanisms of TRIFinduced ISRE and NF-kappa B activation and apoptosis pathways. J Biol Chem
38. Huang J, Teng L, Li L, Liu T, Li L, Chen D, Xu LG, Zhai Z, Shu HB* (2004).
ZNF216 is an A20-like and IKKgamma -interacting inhibitor of NF-kappa B
activation. J Biol Chem 279:16847-16853.
39. Zhang J, Xu LG, Han KJ, Wei X, Shu HB* (2004). PIASy represses TRIF-induced
ISRE and NF-B activation but not apoptosis. FEBS Lett 570:97-101.
40. Zha J, Zhou Q, Xu LG, Chen D, Li L, Zhai Z, Shu HB* (2004). RIP5 is a RIPhomologous inducer of cell death. Biochem Bioph Res Commun 319:298-303. Xu
LG, Li LY, Shu HB* (2004). TRAF7 potentiates MEKK3-induced AP1 and CHOP
activation and induces apoptosis. J Biol Chem 279:17278-17282.
41. Wu M, Xu LG, Su T, Huang J, Zhai Z, Shu HB* (2004). AMID is a p53-inducible
gene down-regulated in tumors. Oncogene 23:6815-6819.
42. Wang YY, Li L, Han KJ, Zhai Z, Shu HB* (2004). A20 is a potent inhibitor of
TLR3- and Sendai virus-induced activation of NF-B and ISRE and IFN-beta
promoter. FEBS Lett 576: 86-90.
43. Lesley R, Xu Y, Kalled SL, Hess DM, Schwab SR, Shu HB, Cyster, JG* (2004).
Reduced competitiveness of autoantigen-engaged B cells due to increased
dependence on BAFF. Immunity 20:441-453.
44. Li L, Bin LH, Li F, Liu Y, Chen D, Zhai Z, Shu HB* (2005). TRIP6 is a RIP2associated common signaling component of multiple NF-B activation pathways. J
Cell Sci 118:555-563.
45. Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB* (2005). VISA is an adapter
protein required for virus-triggered signaling. Mol Cell 19:727-740.
46. Huang J, Liu T, Chen D, Zhai Z, Shu HB* (2005). SIKE is an IKK-relative kinasesassociated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.
EMBO J 24:4018-4028.
47. Su XQ, Li S, Meng M, Qian W, Xie W, Chen D, Zhai Z, Shu HB* (2006). TRAF1
negatively regulates TRIF-mediated signaling. Eur J Immunol 36:199-206.
48. Cusick JK, Xu LG, Bin LH, Han KJ, Shu HB* (2006) Identification of RELT
homologous that associate with RELT and are phosphorylated by OSR1. Biochem
Bioph Res Co 340:535-543.
49. Zha FK, Han K, Xu LG, Zhou Q, Chen D, Zhai Z, Shu HB* (2006). The Ret finger
protein inhibits signaling mediated by the noncanonical and canonical IKK family
members. J Immunol 176:1072-1080.
50. Mei J, Webb S, Zhang B, Shu HB* (2006). The p53-inducible apoptotic protein
51. AMID is not required for development and tumor suppression. Oncogene 25:849856.
52. Huang J, Xu LG, Liu T, Zhai Z, Shu HB* (2006). The p53-inducible E3 ubiquitin
ligase p53RFP induces p53-dependent apoptosis. FEBS Lett 580:940-947.
53. Zhong B, Tien P, Shu HB* (2006). Innate immune response: crosstalk of signaling
and regulation of gene transcription. Virology 352:14-21.
54. Zhang Y, Tian Y, Chen Q, Chen D, Zhai Z, Shu HB* (2007). TTDN1 is a Plk1interacting protein involved in maintenance of cell cycle integrity. Cell Mol Life Sci
55. Tian Y, Zhang Y, Zhong B, Wang YY, Diao FC, Wang RP, Zhang M, Chen DY,
Zhai ZH, Shu HB* (2007). RBCK1 negatively regulates tumor necrosis factor- and
interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. J
Biol Chem 282:16776-16782.
56. Diao F, Li S, Tian Y, Zhang M, Xu LG, Zhang Y, Wang RP, Chen D, Zhai Z, Zhong
B, Tien P, Shu HB* (2007). Negative regulation of MDA5- but not RIG-I-mediated
innate antiviral signaling by the dihydroxyacetone kinase. P Natl Acad Sci USA
57. Lwin T, Crespo LA, Wu A, Dessureault S, Shu HB, Moscinski LC, Sotomayor E,
Dalton WS, Tao J* (2008). Lymphoma cell adhesion-induced expression of B cellactivating factor of the TNF family in bone marrow stromal cells protects nonHodgkin’s B lymphoma cells from apoptosis. Leukemia 23:170-177.
58. Wang RP, Zhang M, Li Y, Diao FC, Chen D, Zhai Z, Shu HB* (2008). Differential
regulation of IKK alpha-mediated activation of IRF3/7 by NIK. Mol Immunol.
59. Chen F, Du Y, Zhang Z, Chen G, Zhang M, Shu HB, Zhai Z, Chen D* (2008).
Syntenin negatively regulates TRAF6-mediated IL-1R/TLR4 signaling. Cell Signal
60. Li LY, Hailey DW, Soetandyo N, Li W, Lippincott-Schwartz J, Shu HB, Ye Y*
(2008). Localization of A20 to a lysosome-associated compartment and its role in
NFB signaling. Biochimica Et Biophysica Acta 1783:1140-1149.
61. Han KJ, Jiang L, Shu HB* (2008). Regulation of IRF2 transcriptional activity by its
sumoylation. Biochem Bioph Res Co 372:772-778.
62. Zhang BC, Huang J, Li HL, Liu T, Wang YY, Waterman P, Mao AP, Xu LG, Zhai Z,
Liu D, Marrack P, Shu HB* (2008). GIDE is a mitochondrial E3 ubiquitin ligase that
induces apoptosis and slows growth. Cell Res 18:900-910.
63. Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao F, Lei C, He X, Zhang L, Tien P, Shu
HB* (2008). The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3
Transcription Factor Activation. Immunity 29:538-550.
64. Zhang M, Tian Y, Wang RP, Gao D, Zhang Y, Diao FC, Chen DY, Zhai ZH, Shu
HB* (2008). Negative feedback regulation of cellular antiviral signaling by RBCK1mediated degradation of IRF3. Cell Res 18:1096-1104.
65. Xiong L, Zhao T, Huang X, Liu ZH, Zhao H, Li MM, Wu LY, Shu HB, Fan M*
(2009). Heat shock protein 90 is involved in regulation of hypoxia-driven
proliferation of embryonic neural stem/progenitor cells. Cell Stress Chaperon
66. Zhong B, Zhang L, Lei Z, Li Y, Mao AP, Yang Y, Wang YY, Zhang XL, Shu HB*
(2009). RNF5 negatively regulates virus-induced IRF3 activation via ubiquitination
and degradation of MITA. Immunity 30:397-407.
67. Li Y, Li C, Xue P, Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang F, Shu HB*
(2009). ISG56 is a negative feedback regulator of virus-triggered signaling and
cellular antiviral response. P Natl Acad Sci USA 106:7945-7950.
68. Zhang M, Wang RP ,Wang YY, Diao FC, Lu F,Gao D, Chen DY, Zhai ZH, Shu,
HB* (2009). The CXXC finger 5 protein is required for DNA damage-induced p53
activation. Sci China Ser C 52:528-538
69. Wang YY, Liu LJ, Zhong B, Liu TT, Li Y, Yang Y, Ran Yong, Li S, Tien P, Shu
HB* (2010). WDR5 is essential for assembly of the VISA-associated signaling
complex and virus-triggered IRF3 and NF-B activation. P Natl Acad Sci USA
70. Ji YT, Qin Y, Shu HB, Li XD* (2010). Methylation analyses on promoters of mPer1,
mPer2, and mCry1 during perinatal development. Biochem Bioph Res Co 391:17421747.
71. Li S, Zheng H, Mao AP, Zhong B, Li Y, Liu Y, Gao Y, Ran Y, Tien P, Shu, HB*
(2010). Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated
deubiquitination of TRAF3 and TRAF6. J Biol Chem 285:4291-4297.
72. Mao AP, Li S, Zhong B, Li Y, Yan J, Li Q, Teng C, Shu HB* (2010). Virustriggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of
interferon-beta (IFN-beta) and cellular antiviral response. J Biol Chem 285:94709476.
73. Han KJ, Yang Y, Xu LG, Shu HB* (2010). Analysis of a TIR-less splice variant of
TRIF reveals an unexpected mechanism of TLR3-mediated signaling. J Biol Chem
74. Zhong B, Zhang Y, Tan B, Liu TT, Wang YY, Shu HB* (2010). The E3 ubiquitin
ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and
degradation. J Immunol 184:6249-6255.
75. Chen R, Zhang L, Zhong B, Tan B, Liu Y, Shu HB* (2010). The ubiquitin-specific
protease 17 is involved in virus-triggered type I IFN signaling. Cell Res 20:802-811.
76. Yi H, Xue L, Guo MX, Ma JA, Zeng Y, Wang W, Cai JY, Hu HM, Shu HB, Shi YB,
Li WX* (2010). Gene expression atlas for human embryogenesis. Faseb J 24:33413350.
77. Lei CQ, Zhong B, Zhang Y, Zhang J, Shu HB* (2010). GSK3 regulates virustriggered IRF3 activation and cellular antiviral response by promoting TBK1
activation. Immunity 33:878-889.
78. Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY* (2011). Resistance
to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptorinduced actin cytoskeletal reorganization. J Biol Chem 286:31055-31061.
79. Ran Y, Liu TT, Zhou Q, Li S, Mao AP, Li Y, Liu LJ, Cheng JK, Shu HB* (2011).
SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and
conditioning it for ubiquitination and degradation. J Mol Cell Biol. 2:283-292.
80. Wu M, Shu HB* (2011). MLL1/WDR5 complex in leukemogenesis and epigenetic
regulation. Chinese J Cancer Res 30:240-246.
81. Li Q, Yan J, Mao AP, Li C, Ran Y, Shu HB*, Wang YY* (2011). Tripartite motif 8
(TRIM8) modulates TNF- and IL-1-triggered NF-B activation by targeting
TAK1 for K63-linked polyubiquitination. P Natl Acad Sci USA 108:19341-19346.
82. Xu LG, Jin L, Zhang BC, Akerlund LJ, Shu HB, Cambier JC* (2012) VISA is
required for B cell expression of TLR7. J Immunol 188:249-258.
83. Liu LJ, Liu TT, Ran Y, Li Y, Zhang XD, Shu HB*, Wang YY* (2012). The E3
ubiquitin ligase MIB1 negatively regulates basal IB level and modulates NF-B
activation. Cell Res 22:603-606.
84. Liu Y, Song R, Gao Y, Li Y, Wang S, Liu HY, Wang Y, Hu YH, Shu HB* (2012).
Protein kinase C-δ negatively regulates T cell receptor-induced NF-B activation by
inhibiting the assembly of CARMA1 signalosome. J Biol Chem 287:20081-20087.
85. Li Y, Chen R, Zhou Q, Xu Z, Li C, Wang S, Mao A, Zhang X, He W, Shu HB*
(2012). LSm14A is a processing body-associated sensor of viral nucleic acids that
initiates cellular antiviral response in the early phase of viral infection. P Natl Acad
Sci USA 109:11770-11775.
86. Wang YY, Ran Y, Shu HB* (2012).Linear ubiquitination of NEMO brakes the
antiviral response.Cell Host Microbe 12:129-131.
87. Zhang J, Hu MM, Wang YY, Shu HB* (2012). TRIM32 protein modulates type I
interferon induction and cellular antiviral response by targeting MITA/STING
protein for K63-linked ubiquitination. J Biol Chem 287:28646-28655.
88. Chen R, Li M, Zhang Y, Zhou Q, Shu HB* (2012). The E3 ubiquitin ligase
MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the
IL1RAP coreceptor for ubiquitination and degradation. P Natl Acad Sci USA
89. Yang ZL, Liang HH, Zhou Q, Li Y, Chen HW, Ye W, Chen DY, Fleming J, Shu HB,
Liu YF*(2012) .Crystal structure of ISG54 reveals a novel RNA binding structure
and potential functional mechanisms. Cell Res 22: 1328-1338.
90. Wang X, Zhu K, Li S, Liao Y, Du R, Zhang X, Shu HB, Guo AY, Li L, Wu M*
(2012) MLL1, a H3K4 methyltransferase, regulates the TNFα-stimulated activation
of genes downstream of NF-κB. J Cell Sci 125:4058-4066.
91. Li Y, He X, Wang S, Shu HB, Liu Y* (2013). USP2a positively regulates TCRinduced NF-B activation by bridging MALT1-TRAF6. Protein Cell 4:62-70.
92. Zheng H, Li Q, Chen R, Zhang J, Ran Y, He X, Li S, Shu HB* (2013).Dualspecificity phosphatase 14 (DUSP14) negatively regulates TNF- and IL-1-induced
NF-κB activation by dephosphorylating the protein kinase TAK1. J Biol Chem
93. Kang X, Chen X, He Y, Guo DY, Guo L, Zhong J, Shu HB*(2013). DDB1 is a
cellular substrate of NS3/4A protease and required for hepatitis C virus replication.
Virology 435: 385-394.
94. He X, Li Y, Li C, Liu LJ, Zhang XD, Liu Y*, Shu HB*(2013). USP2a negatively
regulates IL-1-and virus-induced NF-B activation by deubiquitinating TRAF6. J Mol
Cell Biol 5: 39-47.
95. Yang Y, Liao B, Wang SY, Yan BR, Jin Y, Shu HB, Wang YY*(2013). E3 ligase
WWP2 negatively regulates TLR3-mediated innate immune response by targeting
TRIF for ubiquitination and degradation. P Natl Acad Sci USA 110:5115-5120.
96. Chen H, Li Y, Zhang J, Ran Y, Wei J, Yang Y, Shu HB*(2013) .RAVER1 is a
coactivator of MDA5-mediated cellular antiviral response. J Mol Cell Biol 5: 111119.
97. Wang S, Li Y, Hu YH, Song R, Gao Y, Liu HY, Shu HB, Liu Y* (2013).STUB1 is
essential for T-cell activation by ubiquitinating ARMA1. Eur J Immunol 43:10341041
98. Liu ZG, Wu SW, Lei CQ, Zhou Q, Li S, Shu HB, Wang YY*(2013). Heat shock
cognate 71 (HSC71) regulates cellular antiviral response by impairing formation of
VISA aggregates. Protein Cell. 4: 373-382.
99. Lei CQ, Zhang Y, Xia T, Jiang LQ, Zhong B, Shu HB*(2013). FoxO1 Negatively
Regulates Cellular Antiviral Response by Promoting Degradation of IRF3. J Biol
Chem 288: 12596-12604.
100. Li C, Wei J, Li Y, He X, Zhou Q, Yan J, Zhang J, Liu Y, Liu Y , Shu HB* (2013) .
Transmembrane Protein 214 (TMEM214) Mediates Endoplasmic Reticulum Stressinduced Caspase 4 Enzyme Activation and Apoptosis. J Biol Chem 288: 1790817917.
101. Ding Q, Cao XZ, Lu J, Huang B, Liu YJ, Kato N, Shu HB, Zhong J *(2013).
Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host
innate immunity. J Hepatol 59: 52-58.
102. Hu MM, Yang Q, Zhang J, Liu SM, Zhang Y, Lin H, Huang ZF, Wang YY, Zhang
XD, Zhong B, Shu HB*(2014). TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB
activation by mediating lysosome-dependent degradation of TAB2/3. P Natl Acad
Sci USA. 111:1509-1514.
103. Zhang L, Mo JY, Swanson KV, Wen HT, Petrucelli A, Gregory SM, Zhang ZG,
Schneider M, Jiang Y, Fitzgerald KA, Ouyang SY, Liu ZJ, Damania B, Shu HB,
Duncan JA, Ting JPY* (2014). NLRC3, a Member of the NLR Family of Proteins,
Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor
STING. IMMUNITY. 40:329-341.
104. Yan J, Li Q, Mao AP, Hu MM, Shu HB*(2014). TRIM4 modulates type I interferon
induction and cellular antiviral response by targeting RIG-I for K63-linked
ubiquitination. J Mol Cell Biol. 6:154-163.
105. Zhang J, Hu MM, Shu HB, Li S*(2014). Death-associated protein kinase 1 is an
IRF3/7-interacting protein that is involved in the cellular antiviral immune response.
Cell Mol Immunol. 11: 245-252.
106. Zhang Y, Lei CQ, Hu YH, Xia T, Li M, Zhong B, Shu HB*(2014). Kruppel-like
Factor 6 Is a Co-activator of NF-κB That Mediates p65-dependent Transcription of
Selected Downstream Genes. J Biol Chem. 289:12876-12885.
107. Qin Y, Zhou MT, Hu MM ,Hu YH, Zhang J, Guo L, Zhong B, Shu HB*(2014).
RNF26 temporally regulates virus-triggered type I interferon induction by two
distinct mechanisms. Plos Pathog.10:e1004358.
108. Gong K, Zhang ZX, Chen YC, Shu HB, Li WH* (2014). Extracellular signalregulated kinase, receptor interacting protein, and reactive oxygen species regulate
shikonin-induced autophagy in human hepatocellular carcinoma. Eur J Pharmacol.
738: 142-152.
109. Zhou Q, Lin H, Wang SY, Wang S, Ran Y, Liu Y, Ye W, Xiong XZ, Zhong B, Shu
HB*, Wang YY*(2014). The ER-associated protein ZDHHC1 is a positive regulator
of DNA virus-triggered, MITA/STING-dependent innate immune signaling. Cell
Host Microbe. 16:450-61.
110. Ran Y, Shu HB, Wang YY*(2014). MITA/STING: A central and multifaceted
mediator in innate immune response. Cytokine & Growth F R. 25: 631-639.
111. Shu HB*, Wang YY*(2014). Adding to the STING. Immunity. 41:871-3.
112. Luo WW, Lian H, Zhong B, Shu HB, Li S* (2015). Krüppel-like factor 4 negatively
regulates cellular antiviral immune response. Cell Mol Immunol. doi:
113. Lei CQ, Zhang Y, Li M, Jiang LQ, Zhong B, Kim YH, Shu HB*(2015). ECSIT
Bridges RIG-I-Like Receptors to VISA in Signaling Events of Innate Antiviral
Responses. J Innate Immun. 7:153-164.
114. Hu YH, Zhang Y, Jiang LQ, Wang S, Lei CQ, Sun MS, Shu HB, Liu Y*(2015).
WDFY1 mediates TLR3/4 signaling by recruiting TRIF. EMBO REP. 16: 447-455
115. Zhou MT, Qin Y, Li M, Chen C, Chen X, Shu HB, Guo L*(2015). Quantitative
proteomics reveals the roles of peroxisome-associated proteins in anti-viral innate
immune responses. Mol Cell Proteomics. 14: 2535-2549.
116. An T, Li S, Pan W, Tien P, Zhong B, Shu HB, Wu SW* (2015).DYRK2 Negatively
Regulates Type I Interferon Induction by Promoting TBK1 Degradation via Ser527
Phosphorylation. Plos Pathog.11:e1005179.
117. Lin DD , Zhang M, Zhang MX, Ren YJ , Zhao QY, Jin J , Pan ZS , Wu M, Shu
HB , Dong C , Zhong B*(2015). Induction of USP25 by viral infection promotes
innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6. P
Natl Acad Sci USA. 36 : 11324-11329.
118. Wei J, Lian H, Zhong B, Shu HB*(2015). Parafibromin Is a Component of IFN-γTriggered Signaling Pathways That Facilitates JAK1/2-Mediated Tyrosine
Phosphorylation of STAT1. J Immunol. 195 : 2870-2878.
119. Hu MM, Xie XQ, Yang Q, Liao CY, Ye W, Lin H, Shu HB*(2015).TRIM38
Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses
by Two Sequential and Distinct Mechanisms. J Immunol. 195: 4415-4425.