lansoprazole
What is
lansoprazole?
Lansoprazole belongs to a
group of drugs called proton
pump inhibitors.
Lansoprazole decreases the
amount of acid produced in
the stomach.
Important information
lansoprazole
Lansoprazole is used to treat
and prevent stomach and
intestinal ulcers, erosive
esophagitis (damage to the
esophagus from stomach
acid), and other conditions
involving excessive stomach
acid such as Zollinger-Ellison
syndrome.
Lansoprazole is not for
immediate relief of
heartburn symptoms.
Lansoprazole is not for
immediate relief of
heartburn symptoms.
Lansoprazole may also be
used for other purposes not
listed in this medication
guide.
Heartburn is often confused
with the first symptoms of a
heart attack. Seek
emergency medical attention
if you have chest pain or
heavy feeling, pain spreading
to the arm or shoulder,
nausea, sweating, and a
general ill feeling.
Ask a doctor or pharmacist if
it is safe for you to take
lansoprazole if you have liver
disease, or low levels of
magnesium in your blood.
Some conditions are treated
with a combination of
lansoprazole and antibiotics.
Use all medications as
directed by your doctor.
Read the medication guide
or patient instructions
provided with
each medication. Do not
change your doses or
medication schedule without
your doctor's advice.
If you also take sucralfate
(Gastrofate)), avoid taking it
at the same time you take
lansoprazole. Sucralfate can
make it harder for your body
to absorb lansoprazole. Wait
at least 30 minutes after
taking lansoprazole before
you take sucralfate.
Take lansoprazole for the full
prescribed length of time.
Your symptoms may improve
before the infection is
completely cleared.
Prevacid 24HR should be
taken only once every 24
hours for 14 days. It may
take up to 4 days for full
effect. Do not take more
than one tablet every 24
hours.
1
Allow at least 4 months to
pass before you start
another 14-day treatment
with Prevacid 24HR. Call your
doctor if you have additional
symptoms and need
treatment before the 4
months has passed.
Before taking lansoprazole
You should not use this
medication if you are allergic
to lansoprazole.
Ask a doctor or pharmacist if
it is safe for you to take
lansoprazole if you have liver
disease, or low levels of
magnesium in your blood.
Heartburn is often confused
with the first symptoms of a
heart attack. Seek
emergency medical attention
if you have chest pain or
heavy feeling, pain spreading
 trouble or pain with
swallowing;
 bloody or black stools;
 vomit that looks like
blood or coffee
grounds;
Some conditions are treated
with a combination of
lansoprazole and antibiotics.
Use all medications as
directed by your doctor.
to the arm or shoulder,
nausea, sweating, and a
general ill feeling.
 heartburn that has
lasted for over 3
months;
 frequent chest pain;
 heartburn with
wheezing;
 unexplained weight
loss;
Read the medication guide
or patient instructions
provided with each
medication. Do not change
your doses or medication
2
Do not use over-the-counter
lansoprazole without the
advice of a doctor if you
have:
 nausea or vomiting;
 stomach pain: or
 an electrolyte
imbalance or metabolic
disorder.
schedule without your
doctor's advice.
Taking a proton pump
inhibitor such as
lansoprazole may increase
your risk of bone fracture in
the hip, wrist, or spine. This
effect has occurred mostly in
people who have taken the
medication long term or at
high doses, and in those who
are age 50 and older. It is not
clear whether lansoprazole is
the actual cause of an
increased risk of fracture.
Before you take lansoprazole
, tell your doctor if you have
osteoporosis or osteopenia
(low bone mineral density).
FDA pregnancy category B.
Lansoprazole is not expected
to be harmful to an unborn
baby. Tell your doctor if you
are pregnant or plan to
become pregnant during
treatment. It is not known
whether lansoprazole passes
into breast milk or if it could
harm a nursing baby. Do not
use this medication without
telling your doctor if you are
breast-feeding a baby.
Some forms of lansoprazole
may contain phenylalanine.
Tell your doctor if you have
phenylketonuria.
Do not give lansoprazole to a
child younger than 1 year
old.
3
How should I take
lansoprazole?
Take lansoprazole exactly as
prescribed by your doctor.
Do not take in larger or
smaller amounts or for
longer than recommended.
Follow the directions on your
prescription label.
Lansoprazole is usually taken
before eating. Follow your
doctor's instructions.
Do not crush or break a
lansoprazole delayed-release
capsule. Swallow it whole.
Breaking the pill may cause
too much of the drug to be
released at one time.
If you are unable to swallow
a lansoprazole delayedrelease capsule whole: Open
the capsule and sprinkle the
medicine into a spoonful of
pudding, applesauce, yogurt,
cottage cheese, strained
pears, or a nutritional drink
such as Ensure. Swallow this
mixture right away without
chewing. Do not save the
mixture for later use. Discard
the empty capsule.
You may also dissolve the
medicine from a
lansoprazole capsule in 2
ounces (1/4 cup) of apple
juice, orange juice, or tomato
juice. Stir this mixture and
drink all of it right away. To
make sure you get the entire
dose, add a little more juice
to the same glass, swirl
gently and drink right away.
Dissolve the oral granules in
2 tablespoons of water. Use
only water when mixing
lansoprazole oral granules.
Stir this mixture and drink all
of it right away. To make
sure you get the entire dose,
add a little more water to the
same glass, swirl gently and
drink right away.
To take lansoprazole orally
disintegrating tablet: Use dry
hands to remove the tablet
and place it in your mouth. It
will begin to dissolve right
away. Allow the tablet to
dissolve in your mouth
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without chewing, swallowing
several times as it dissolves.
The orally disintegrating
tablet should not be given
with an oral syringe or given
through a nasogastric (NG)
feeding tube. The tablet may
not dissolve completely and
could clog the syringe or
tube.
Prevacid 24HR should be
taken only once every 24
hours for 14 days. Take the
medicine in the morning
before you eat breakfast. It
may take up to 4 days for full
effect. Do not take more
than one tablet every 24
hours.
Allow at least 4 months to
pass before you start
another 14-day treatment
with Prevacid 24HR. Call your
doctor if you have additional
symptoms and need
treatment before the 4
months has passed.
Do not crush, chew, or break
a Prevacid 24HR capsule.
Swallow the pill whole. Take
this medication for the full
prescribed length of time.
Your symptoms may improve
before the infection is
completely cleared. Call your
doctor if your symptoms do
not improve or if they get
worse while you are taking
this medicine. Store at room
temperature away from
moisture and heat.
What happens if I
miss a dose?
What should I avoid
while taking
lansoprazole?
Take the missed dose as
soon as you remember. Skip
the missed dose if it is almost
time for your next scheduled
dose. Do not take extra
medicine to make up the
missed dose.
If you also take sucralfate ,
avoid taking it at the same
time you take lansoprazole.
Sucralfate can make it harder
for your body to absorb
lansoprazole. Wait at least
30 minutes after taking
lansoprazole before you take
sucralfate.
What happens if I
overdose?
Lansoprazole side
effects
Seek emergency medical
attention
Get emergency medical help
if you have any of these signs
of an allergic reaction to
lansoprazole: hives; difficulty
5
breathing; swelling of your
face, lips, tongue, or throat.
 dizziness, confusion;
 fast or uneven heart
rate;
 jerking muscle
movements;
 feeling jittery;
.
This is not a complete list of
side effects and others may
occur. Call your doctor for
medical advice about side
effects. You may report side
effects to FDA at 1-800-FDA1088.
See also: Lansoprazole side
effects (in more detail)
Stop using lansoprazole and
call your doctor at once if
 muscle cramps, muscle
weakness or limp
feeling;
 cough or choking
feeling; or
 seizure (convulsions).
you have symptoms of low
magnesium:
 Less serious
lansoprazole side
effects may include:
 headache;
 nausea, stomach pain;
 diarrhea; or
 constipation
Lansoprazole
Dosing Information
administered over 30
minutes for up to 7 days.
Usual
Adult Lansoprazole
Dose for Erosive Esophagitis:
Maintenance dose: 15 mg
orally once a day.
Initial dose: 30 mg orally
once a day for up to 8 weeks.
Alternatively, if the patient is
unable to use oral route the
dose may be given as an IV
infusion of 30 mg per day
Usual Adult Lansoprazole
Dose for Duodenal Ulcer:
6
15 mg orally once a day 30
minutes before eating.
Therapy should be continued
for up to 4 weeks.
Usual Adult Lansoprazole
Dose for Gastroesophageal
Reflux Disease:
15 mg orally once a day.
Therapy should be continued
for up to 8 weeks.
Usual Adult Lansoprazole
Dose for Gastric Ulcer:
30 mg orally once a day 30
minutes before eating.
Therapy should be continued
for 4 to 8 weeks.
Usual Adult Lansoprazole
Dose for Multiple Endocrine
Adenomas:
60 mg orally once a day.
Doses up to 90 mg orally 2
times a day have been used.
The manufacturer reports
that some patients have
been treated continuously
for as long as four years.
Usual Adult Lansoprazole
Dose for Systemic
Mastocytosis:
60 mg orally once a day.
Doses up to 90 mg orally 2
times a day have been used.
The manufacturer reports
that some patients have
been treated continuously
for as long as four years.
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Usual Adult Lansoprazole
Dose for Zollinger-Ellison
Syndrome:
60 mg orally once a day.
Doses up to 90 mg orally 2
times a day have been used.
The manufacturer reports
that some patients have
been treated continuously
for as long as four years.
Usual Adult Lansoprazole
Dose for Helicobacter pylori
Infection:
Triple therapy: lansoprazole
30 mg is combined with 1 g
of amoxicillin and 500 mg of
clarithromycin given orally
every 12 hours for 10 or 14
days. Most investigators
recommend treatment with
at least two antimicrobial
agents in order to achieve
eradication. Monotherapy
with lansoprazole is
ineffective and should be
avoided.
Dual therapy: lansoprazole
30 mg is combined with 1
gram of amoxicillin given
orally every 8 hours for 14
days. Refer to the
monograph for amoxicillin
and/or clarithromycin for
dosing information specific
to elderly or renally-impaired
patients.
Usual Adult Lansoprazole
Dose for Duodenal Ulcer
Prophylaxis:
15 mg orally once a day 30
minutes before eating.
Studies evaluating
maintenance therapy for
duodenal ulcers have not
extended beyond 12 months.
Usual Adult Lansoprazole
Dose for NSAID-Induced
Gastric Ulcer:
30 mg orally once a day for 8
weeks.
Usual Adult Lansoprazole
Dose for NSAID-Induced
Ulcer Prophylaxis:
15 mg orally once a day for
up to 12 weeks.
Usual Pediatric Dose for
Aspiration Pneumonia:
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Greater than 3 to 11 years:
30 mg at 9 p.m. the night
before surgery, and 30 mg at
5:30 a.m. the day of surgery.
Usual Pediatric Dose for
Gastroesophageal Reflux
Disease:
Short term treatment of
GERD (up to 12 weeks):
1 to 11 years:
Less than or equal to 30 kg =
15 mg once daily
Greater than 30 kg = 30 mg
once daily
12 to 17 years: 15 mg once
daily for up to 8 weeks
Usual Pediatric Dose for
Erosive Esophagitis:
Short term treatment (up to
12 weeks):
1 to 11 years:
Less than or equal to 30 kg =
15 mg once daily
Greater than 30 kg = 30 mg
once daily, up to 30 mg twice
daily.
Short term treatment (up to
 ampicillin (Principen,
Unasyn);
 atazanavir (Reyataz);
 digoxin (Lanoxin,
Lanoxicaps);
 ketoconazole (Nizoral);
This list is not complete and
other drugs may interact
with lansoprazole. Tell your
doctor about all medications
8 weeks):
12 to 17 years: 30 mg once
daily
An additional 8 weeks may
be tried in those patients
who fail to respond or for a
recurrence.
Maintenance: 15 mg once
daily
 a blood thinner such as
warfarin (Coumadin,
Jantoven);
 a diuretic (water pill);
 iron (Feosol, Mol-Iron,
Fergon, Femiron,
others); or
you use. This includes
prescription, over-thecounter, vitamin, and herbal
products. Do not start a new
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What other drugs
will affect
lansoprazole?
Tell your doctor about all
other medicines you use,
especially:
 theophylline (such as
Elixophyllin, Respbid,
Slo-Bid, Theobid,
Theoclear, Theo-Dur,
Uniphyl).
medication without telling
your doctor.