Prepared: February 17, 2016 SHEZHANG LIN, MD, MMR 3D Specialist Advanced Image Processing Lab Department of Radiology Beth Israel Deaconess Medical Center Education 02/1978-12/1982 09/1985-08/1987 MD MMR 330 Brookline Ave., Boston MA 02215 Phone: (617) 667-5755 E-mail: slin2@bidmc.harvard.edu Shanghai Medical University, Shanghai, China Department of Radiology, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China (MMR: Master of Medicine in Radiology) 01/1998 Residency Training 12/1982-12/1987 07/1998-07/1999 ECFMG Certificate (ID: 0-551-328-8), permanent, USA Diagnostic Radiology Resident, Department of Radiology, Peking Union Medical College Hospital, Beijing, China. Transitional Year Resident, Department of Internal Medicine, Catholic Health Partners, Chicago, Illinois. Employment Experience 12/1987-08/1990 Attending Radiologist, Section of Gastroenterology, Department of Radiology, Peking Union Medical College Hospital, Beijing, China. 09/1988-08/1990 Director, Section of Gastroenterology, Department of Radiology, Peking Union Medical College Hospital, Beijing, China. 11/1990-11/1993 Research Fellow, Division of Gastroenterology, Department of Medicine, Northwestern University Medical School, Chicago, Illinois. 11/1993-04/1995 Research Associate, Division of Gastroenterology & Hepatology, Department of Medicine, Northwestern University Medical School, Chicago, Illinois. 04/1995-06/1998 Research Assistant Professor, Division of Gastroenterology & Hepatology, Department of Medicine, Northwestern University Medical School, Chicago, Illinois. 10/1999-08/2004 Research Assistant Professor, Imaging Science and Information Systems (ISIS) Center, Department of Radiology, Georgetown University Medical Center, Washington, DC. 09/2004-01/2005 Consulting contractor for 3D imaging project/package development, Anderson Orthopaedic Research Institute, Alexandria, VA. 02/20053D Specialist, Advanced Image Processing Lab, Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA Memberships, Offices, and Committee Assignments in Professional Societies 1985-1990 Chinese Association of Radiology, Beijing Branch 1996-1998 American Gastroenterological Association 2001-2002 Radiological Society of North America Awards and Honors 1987-1990 Principal investigator, Grant #87-Y-085 from the Health Ministry of China. Title: The relationship of phrenic ampullary emptying and gastroesophageal reflux disease Shezhang Lin, Résumé 1995-1996 1995-1998 2001 Co-investigator, Grant from Northwestern Memorial Foundation Intramural Research Grants Program. Title: The role for esophageal longitudinal muscle in the development of esophageal propulsive force (Principal Investigator, Gulchin A. Ergun) Co-investigator, Grant #1 RO1 DC00646 from the Public Health Service. Title: Volitional, bolus, and age effects on human swallowing (Principal Investigator, Peter J. Kahrilas) RSNA 2001 annular meeting, Education Exhibit Award for Excellence in Design. Web-based education project: Stroke Territory on CT and MRI Publications Original Reports 1. Shi HP, Luo HY, Yan HZ, Lin S. Spondyloepiphyseal dysplasia congenita - one case report. Acta Academiae Medicinae Sinicae 1985;7:160-161. 2. Shi HP. Luo HY, Lin S, Xie YZ. Pseudoachondroplasia - two cases report. Acta Academiae Medicinae Sinicae 1986;8:74-74. 3. Zhang TL, Lin S, Xi TX. Radiological diagnosis of metastatic cancer of rectum and sigmoid colon via direct invasion and peritoneal implantation. Chinese Journal of Radiology 1986;20:353-356. 4. Lin S, Zhang TL. Effect of glucagon on esophageal smooth muscle motor function. Chinese Medical Journal 1989;102:193-196. (in English) 5. Lin S. Annular pancreas: etiology, Classification and diagnostic imaging. Chinese Medical Journal 1989;102:368-371. (in English) 6. Lin S, Liu ZR. Papillary adenoma of the gallbladder - one case report. Journal of Clinical Radiology 1989;8:204-205. 7. Wang TA, Zhao RG, Lin S. Cavernous hemangioma in the small intestine - one case report. Chinese Journal of Radiology 1989;23:110-111. 8. Hai JK, Lin S, Guo ZL. Acute cecal volvulus: analysis of 84 cases. National Medical Journal of China 1990; 70:350-351. 9. Lin S, Wang TA, Xing FY, Xi TX, Zhao RG, Zhang TL. Colonic diverticulum in Chinese subjects: 24 cases report and literature review. Chinese Journal of Radiology 1990;24 (supplement.):47-49. 10. Ke MY, Lin S, Tong SW, Xu JY, Lu SH, Chen SP, Yang XS. Evaluation of drug therapy and balloon dilatation on Achalasia. Endoscopy 1990;7:2-5. 11. Logemann JA, Kahrilas PJ, Cheng J, Pauloski BR, Gibbons PJ, Rademaker F, Lin S. Closure mechanisms of the laryngeal vestibule during swallow. Am J Physiology 1992; 262:G338-344. 12. Kahrilas PJ, Logemann JA, Lin S, Ergun GA. Pharyngeal clearance during swallow: a combined manometric and videofluoroscopic study. Gastroenterology 1992;103:128-136. 13. Kahrilas PJ, Lin S, Logemann JA, Ergun GA, Facchini F. Deglutitive tongue action: volume accommodation and bolus propulsion. Gastroenterology 1993;104:152-162. 14. Ergun AG, Kahrilas PJ, Lin S, Logemenn JA, Harig JM. Shape, volume, and content of the deglutitive pharyngeal chamber imaged by ultrafast computerized tomography. Gastroenterology 1993;105:1396-1403. 15. Lin S, Meiyun Ke, Jingying Xu, Kahrilas PJ. Impaired esophageal emptying in reflux disease. Am J Gastroenterol 1994;89:1003-1006. 16. Lin S, Brasseur JG, Pouderoux P, Kahrilas PJ. The phrenic ampulla: distal esophagus or potential hiatal hernia? Am J Physiology 1995;268:G320-G327 17. Kahrilas PJ, Lin S, Chen Jim, Logemann JA. Three dimensional modeling of the oropharynx during swallowing. Radiology 1995;194:575-579. Page 2 Shezhang Lin, Résumé 18. Kahrilas PJ, Wu S, Lin S, Pouderoux P. Attenuation of esophageal shortening during peristalsis with hiatus hernia. Gastroenterology 1995;109:1818-1825 19. Pouderoux P, Ergun AG, Lin S, Kahrilas PJ. Esophageal bolus transit imaged by ultrafast 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. computerized tomography. Gastroenterology 1996;110:1422-1428 Kahrilas PJ, Lin S, Chen Jim, Logemann JA. Oropharyngeal accommodation to swallow volume. Gastroenterology 1996;111:297-306 Lin S, Chen J, Hertz P, Kahrilas PJ. Dynamic reconstruction of the oropharyngeal swallow using computer based animation. Computerized Medical Imaging and graphics 1996;20:69-75 Pouderoux P, Lin S, Kahrilas PJ. Timing, propagation, coordination, and effect of esophageal shortening during peristalsis. Gastroenterology 1997;112:1147-1154 Kahrilas PJ, Lin S, Rademaker AW, Logemann JA. Impaired deglutitive airway protection: a videofluoroscopic analysis of severity and mechanism. Gastroenterology 1997;113:1457-1464 Kahrilas PJ, Lin S, Spiess AE, Brassure JG, Joehl RJ and Michael Manka. Impact of fundoplication on bolus transit across the esophagogastric junction. Am J Physiology 1998;275:G1386-G1393 Kahrilas PJ, Lin S, Chen J, Manka M. The effect of hiatus hernia on gastro-oesophageal junction pressure. Gut 1999;44:476-482 Kahrilas PJ, Lin S. Esophagogastric Junction Pressure Topography After Fundoplication. Surgery 2000;127:200-208 Boiselle PM, Lee KS, Lin S, Raptopoulos V. Cine CT During Coughing for Assessment of Tracheomalacia: Preliminary Experience with 64-Multidetector-Row CT. AJR 2006;187(2):W175177 Hakimé A, Peddi H, Hines-Peralta AU, Wilcox CJ, Kruskal J, Lin S, de Baere T, Raptopoulos VD, Goldberg SN. CT perfusion for determination of pharmacologically mediated blood flow changes in an animal tumor model. Radiology. 2007;243(3):712-9 Clouse ME, Yoshimura N, Sabir A, Lin S, Raptopoulos VD. A New Method of Measuring NonCalcified Coronary Atherosclerotic Disease by MDCTA. (AJR in Press) Reviews 1. Lin S. Balloon catheter dilation of esophageal strictures. Foreign Medicine, Portion of Clinical Radiology 1985;8:1-3. 2. Lin S. Radiological diagnosis of lymphomatoid granulomatosis in the lung. The Journal of Practical Radiology 1985;4:208-2111. 3. Lin S. Defecography and its clinical application. Foreign Medicine, Portion of Clinical Radiology 1987;10:11-13. 4. Lin S. Medication-induced esophagitis. Foreign Medicine, Portion of Clinical Radiology 1987;10:204-206. 5. Lin S, Hu MH. Radiological feature of the pharyngoesophageal movement (I). Journal of Clinical Radiology 1987; 6:302-305. 6. Lin S, Hu MH. Radiological feature of the pharyngoesophageal movement (I). Journal of Clinical Radiology 1988; 7:22-25. 7. Lin S. Physiologic and radiological feature of the movement of the esophageal smooth muscle. Foreign Medicine, Portion of Clinical Radiology 1988;11:138-141. Abstracts Presented at National and International Meetings 1. Kahrilas PJ, Logemenn JA, Gibbons P, Pauloski B, Lin S, Ergun GA. Pharyngeal wall contraction during swallow: not peristalsis. Gastroenterology 1991;100:A445. Presented at Digestive Disease Week, New Orleans, May, 1991 (oral research symposium). Page 3 Shezhang Lin, Résumé 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. Kahrilas PJ, Lin S, Ergun GA, Facchini F, Logemann JA. Deglutitive tongue action: volume accommodation & bolus propulsion. Gastroenterology 1992;102:A464. Presented at Digestive Disease Week, San Francisco, May, 1992. Lin S, Kahrilas PJ, Ergun GA, Facchini F. Size and emptying of the phrenic ampulla: not just and esophageal matter. Gastroenterology 1992;102:A476. Presented at Digestive Disease Week, San Francisco, May, 1992. Kahrilas PJ, Lin S, Ergun GA, Facchini F, Logemann JA. Three dimensional modeling of the pharyngeal pump during liquid swallows. Gastroenterology 1992;103:1409. Presented at the American Motility Society, Late Tahoe, September, 1992. Ergun AG, Kahrilas PJ, Lin S, Logemenn JA. Pattern and modulation of tongue surface movement during deglutition. Dysphagia Research Society, 1992 Ergun AG, Kahrilas PJ, Chiao G, Lin S. Does the degree of effort during swallow modify oropharyngeal biomechanics? Gastroenterology 1993;104:A75. Presented at Digestive Disease Week, Boston, May, 1993 (oral research symposium). Ergun AG, Harig JM, Lin S, Chomka E, Kahrilas PJ. Pharyngeal configuration and air content during swallows imaged by ultrafast CT. Gastroenterology 1993;104:A503. Presented at Digestive Disease Week, Boston, May, 1993 (oral research symposium). Chiao GZ, Larson CR, Lin S, Shaker R, Layman R, Kahrilas PJ. Lingual accommodation to bolus viscosity during deglutition in a conscious monkey, Gastroenterology 1994;106:A479. Presented at Digestive Disease Week, New Orleans, May, 1994. Ergun AG, Lin S, Abu-Hammour A, Logemann JA, Kahrilas PJ. Repetitive oropharyngeal swallows imaged by ultrafast CT. Gastroenterology 1994;106:A495. Presented at Digestive Disease Week, New Orleans, May, 1994 (oral research symposium). Ergun AG, Lin S, Abu-Hammour A, Kahrilas PJ. Esophageal bolus transit imaged by ultrafast CT. Gastroenterology 1994;106:A495. Presented at Digestive Disease Week, New Orleans, May, 1994. Kahrilas PJ, Lin S, Chen J, Logemann JA. Three dimensional modeling of the oropharynx during swallowing. Gastroenterology 1994;106:A521. Presented at Digestive Disease Week, New Orleans, May, 1994. Lin S, Kahrilas PJ, Chen J. Deglutitive trans-upper esophageal sphincter (UES) flow rate. Clinical Research. 1994;42:403A. Presented at Annual Meetings of the Central Society for Clinical Research, Chicago, September, 1994. Kahrilas PJ, Lin S, Chen J. Flow rate through the upper esophageal sphincter during swallowing. Gastroenterology 1994;107:1238. Presented at the meeting of American Motility Society, Biennial symposium, Wintergreen, October , 1994. Lin S, Chen J, Kahrilas PJ, Hertz P. Three dimensional animation of the oropharyngeal swallow. Radiology 1994;193(P):446 CD-ROM presentation at the 80th Scientific Assembly and Annual Meeting of the Radiological Society of North America, Scientific Exhibits, Chicago, November 27December 2, 1994. Lin S, Kahrilas PJ, Chen J, Logemann JA. Hypopharyngeal compliance among bolus volumes regulates outflow during swallow. Gastroenterology 1995;108:A639. Presented at Digestive Disease Week, San Diego, May 14-17, 1995. Lin S, Kahrilas PJ. Diminished distal esophageal emptying pressure and efficacy with hiatus hernia. Gastroenterology 1995;108:A150. Presented at Digestive Disease Week, San Diego, May 14-17, 1995. Wu S, Lin S, Kahrilas PJ. Impairment of esophageal longitudinal muscle function with hiatus hernia. Gastroenterology 1995;108:A260. Presented at Digestive Disease Week, San Diego, May 14-17, 1995. Page 4 Shezhang Lin, Résumé 18. Lin S, Logemann JA, Kahrilas PJ. Mechanics of aspiration during swallow. Neurogastroenterology 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. and Motility 1995;7:269. Presented at the Fifteenth International Symposium on Gastrointestinal Motility, November 5-9, 1995. Pouderoux P, Wu S, Lin S, Ergun G, Kahrilas PJ. Coordinated action of esophageal longitudinal and circular muscle generate propulsive force. Neurogastroenterology and Motility 1995;7:281. Presented at the Fifteenth International Symposium on Gastrointestinal Motility, November 5-9, 1995. Lin S, Logemann JA, Kahrilas PJ. Mechanics of impaired laryngeal closure in patients with aspiration during swallow. Gastroenterology 1996;110:A177. Presented at Digestive Disease Week, San Diego, May 19-22, 1996. Kahrilas PJ, Lin S, Logemann JA. Temporal modulation within the swallow response: beginning, end, or middle? Gastroenterology 1996;110:A689. Presented at Digestive Disease Week, San Diego, May 19-22, 1996. Lin S, Kahrilas PJ, Chen J, Logemann JA. Dynamic 3-dimensional configuration of the tongue during swallow. Gastroenterology 1996;110:A707. Presented at Digestive Disease Week, San Diego, May 19-22, 1996. Pouderoux P, Lin S, Ergun G, Kahrilas PJ. Synchronization of esophageal longitudinal and circular muscle contraction during peristalsis. Gastroenterology 1996;110:A738. Presented at Digestive Disease Week, San Diego, May 19-22, 1996. Pouderoux P, Lin S, Ergun G, Kahrilas PJ. Longitudinal muscle contraction determines the amplitude of traction force within the esophagus. Gastroenterology 1996;110:A738. Presented at Digestive Disease Week, San Diego, May 19-22, 1996. Lin S, Chen J, Manka M, Kahrilas PJ. The LES and the hiatal sphincter: in unity there is strength. Gastroenterology 1997;112:A199. Presented at Digestive Disease Week, Washington, DC, May 1016, 1997. Kahrilas PJ, Lin S, Rademaker AW, Logemann JA. Predictors of airway penetration during swallow. Gastroenterology 1997;112:A758. Presented at Digestive Disease Week, Washington, DC, May 10-16, 1997. Lin S, Kahrilas PJ . Altered lower esophageal sphincter mechanics during swallow in patients with hiatus hernia. Gastroenterology 1997;112:A776. Presented at Digestive Disease Week, Washington, DC, May 10-16, 1997. Lin S, Spiess AE, Manka M, Chen J, Joehl RJ, Kahrilas PJ. Pressure morphology of the gastroesophageal junction after fundoplication: how normal is it? Gastroenterology 1998;114:A204(G0835). Presented at Digestive Disease Week, New Orleans, LA, May 17-20, 1998. Lin S, Kahrilas PJ, Logemann JA. Determinants of swallow recovery after stroke: motor, sensory, or both? Gastroenterology 1998;114:A791(G3255). Presented at Digestive Disease Week, New Orleans, LA, May 17-20, 1998. Ergun GA, Lin S, Joehl RJ, Kahrilas PJ. Successful vs “less successful” fundoplications: too loose? Gastroenterology 1998;114:A114(G0471). Presented at Digestive Disease Week, New Orleans, LA, May 17-20, 1998. Spiess AE, Lin S, Joehl RJ, Kahrilas PJ. Impaired gastroesophageal junction transit with fundoplication. Gastroenterology 1998;114:A293(G1203). Presented at Digestive Disease Week, New Orleans, LA, May 17-20, 1998. Lin S. Videofluoroscopic Biomechanical Analysis of Phrenic Ampullar Emptying. Web-based presentation. InfoRAD Exhibit, the 87th Scientific Assembly and Annual Meeting of the Radiological Society of North America, Chicago, November 25- 30, 2001. Page 5 Shezhang Lin, Résumé 33. Lin S, Makariou EV, Freedman M. Stroke Territory on CT and MRI: How to Identify the Arterial 34. 35. 36. 37. Territory of an Ischemic Stroke Lesion. Education Exhibit, the 87th Scientific Assembly and Annual Meeting of the Radiological Society of North America, Chicago, November 25- 30, 2001. Lin S. Videofluoroscopic Biomechanical Analysis of Pharyngeal Swallow. Web-based presentation. Education Exhibit, the 87th Scientific Assembly and Annual Meeting of the Radiological Society of North America, Chicago, November 25- 30, 2001. Lin S, Clouse ME, Yoshimura N, Sabir A, Munro R, Wilcox CJ, Raptopoulos VD. Volume Evaluation of Non-Calcified Coronary Plaque Using MDCTA 16/64. Scientific Paper Session (4418881), the 87th Scientific Assembly and Annual Meeting of the Radiological Society of North America, Chicago, November 27- December 2, 2005. Brennan DD, Kruskal JB, Rofsky NM, Kane RA, Zamboni G, Lin S. Multimodality Assessment of the Vascular Complications of Adult Liver Transplantation. Education Exhibits (4417260), the 87th Scientific Assembly and Annual Meeting of the Radiological Society of North America, Chicago, November 27- December 2, 2005. Brennan DD, Kruskal JB, Appelbaum L, Raptopoulos VD, Zamboni G, Lin S. Comprehensive Preoperative Assessment of Pancreatic Cancer Using 64-row Volumetric CT. Education Exhibits (4414645), the 87th Scientific Assembly and Annual Meeting of the Radiological Society of North America, Chicago, November 27- December 2, 2005. Web Publication 1. Lin S. 3D imaging Requires Overhaul of Radiology (Perspective). DiagnosticImaging.com:PACSweb:Features, Apr 24, 2003. (http://www2.dimag.com/pacsweb/features/?id=3540). Lectures 1. Resident Lectures, Department of Radiology, Georgetown University Medical School, 2001 a. Biomechanical Analysis of Pharyngeal Swallow. b. Biomechanical Analysis of Phrenic Ampullary Emptying, c. Stroke Territory on CT and MRI. 2. Videofluoroscopic Biomechanical Analysis of Pharyngeal Swallow. Invited presentation at the Department of Radiology, Brigham & Women's Hospital, Harvard Medical School, November 2001. 3. Benefits and Challenges:3D/4D Imaging Diagnosis. Invited presentation at the Department of Radiology, Thomas Jefferson University, March 2003. 4. 3D CT Imaging Diagnosis: Clinical Research and Development. Learning Institute Presentation at Philips Medical Systems (Cleveland), Inc, August 2003. 5. 3D Imaging Diagnosis: Clinical Application. Invited presentation at the Department of Radiology, Peking Union Medical College Hospital, July 2004. 6. Biomechanical Imaging Diagnosis of Swallowing and Its Clinical Application. Invited presentation at the 4th symposium of Functional Gastrointestinal Disorders and Psychological Disorders. Peking Union Medical College Hospital, July 2004. Patent Application 1. Clouse ME, Raptopoulos VD, Lin S, Sabir A. Voxel Histogram Analysis For Measurement Of Plaque (04547-024001, BIDMC 926), 2005 Page 6