Yan Shi U of Calgary CV 2011
I.
BIOGRAPHICAL DATA
Name
Address
Telephone
Marital Status
Nationality
Yan Shi
4A18 HRIC, University of Calgary, Calgary, AB T2N 4N1
403-220-2536
Married to Huining Fang, with Children Kristen and Peter
U.S.A, with PR in Canada
Present rank
Department
Faculty
Institution
Associate Professor
Microbiology & Infectious Diseases
Medicine
University of Calgary
II.
ACADEMIC RECORD
Final degree:
Date completed:
Specialty:
Institution
PhD
Sept 1998
Immunology
Univ of Iowa, Iowa City, USA
Undergraduate
MSc
B.Med (M.D. equivalent), Shanghai Medical Univ 1988
Univ of Iowa 1992
III.
AWARDS AND DISTINCTIONS
Keystone Travel award 2004
IV.
ACADEMIC APPOINTMENTS
20102006-2011
2006-2011
2006-2010
200620062003-2006
1997-2003
1988-1990
Associate Professor, Univ. of Calgary, Calgary, Alberta, Canada
Alberta Heritage Foundation for Medical Research Scholar
Canada Research Chair in Immune Regulation (Tier II)
Assistant Professor, Univ. of Calgary, Calgary, Alberta, Canada
Member, Immunology Research Group, Univ of Calgary
Member, Julia McFarlene Diabetes Research Centre, University of Calgary
Research Assistant Professor, Univ. of Massachusetts Medical School.
Post doctoral Fellow. Univ. of Massachusetts Medical School,
Worcester, Massachusetts.
Quarantine Doctor. Shanghai Quarantine Services, Shanghai, China
V.
EDUCATIONAL ACTIVITIES
i.
Undergraduate
Supervisor for
Winston Pong 2008-2009 and Summers of 2007, 2008, 2009,
Elaine Chau
Summer of 2008
Gilbert Ng
2007-2008, and Summers 2007 and 2008
Yin Fong
Summer of 2009
Fay Munro
Spring 2011
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Yan Shi U of Calgary CV 2011
Aude Georget
ii.
Foreign exchange student 2010-2011
Graduate
Teaching
2006-2007 639.02 Cellular and Molecular Immunology IMM2 2 hrs
2007-2008 639.02 Cellular and Molecular Immunology IMM2 6 hrs
2010- Coordinator of 639.02
Ashley Mucsi
Gilbert Ng
Aswin Hari
Faranak Oskouie
Uliana Kanevets
Tracy Flach
Ailian Yang:
Courtney Willard:
Mina Seedhom:
May 2009 Sept 2008 – 2011 (expected)
May 2008 Jan 2008 - 2010 (expected)
Sept 2007 - 2009
Sept 2007 - 2010
Jan 2007 - 2009
Jan 2002 - Mar 2004
Jan 2004 - May 2004 (co-supervisor)
iii.
Postgraduate (research and clinical fellows)
Arron Hearn:
Oct 2003 - March 2006 (co-supervisor)
Lisa Wang:
Jan 2011 – (visiting research scientist)
VI.
ADMINISTRATIVE RESPONSIBILITIES
i.
ii.
iii.
Departmental
Faculty
Organizer of IRG student seminar series 2007Organizer of IRG Journal Club seminar series 2007- 2010
Organizer of IRG External Speaker seminar series 2007- 2010
IRG reestablishment committee 2007
University
VII.
PROFESSIONAL ACTIVITIES
i.
Membership in professional and learned societies.
American Association of Immunologists
Canadian Society of Immunology
Canada Research Chair in Immunology
AHFMR Scholar
ii.
Professional service
Grant review
CIHR (NIH equivalent) operating grants
CIHR/China Joint grants
Canada Research Chair applications
CIHR: Canada-Chair Joint Research grant reviewer
Department of Surgery internal grant reviewer
Journal review
EBMO
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Yan Shi U of Calgary CV 2011
Journal of Immunology (frequent reviewer)
Journal of Leukocyte Biology (frequent reviewer)
Plos One
Plos Biology
British Journal of Pharmacology
iii.
Government Agencies
1.
Expert discussion panel on the Department of Defense DARPA Endogenous Defense
Workshop, Fairfax, Virginia, USA.
2.
Expert discussion panel on Center for Technology and National Security Policy National
Defense University, Fort McNair, Washington DC, USA
3.
Chair: AAI annual meeting Seattle, Washington May 2009
VIII.
RESEARCH SUPPORT
1.
2.
NIH 1R21AI089963-01. Alum's adjuvanticity (PI).
06/2010 to 05/2012, USD 275,000/2yrs
NSERC Discovery Grant. Biophysical basis of single cell force spectroscopy (PI) 04/2010
– 03/2015, CAD 66,000 /yr
Finished
1.
2.
3.
4.
5.
4.
IX.
CIHR MOP-86468. Purine in Immune Regulation (PI)
02/2008-/01/2011, Direct Cost CAD 65,000/yr
CIHR MOP 81212, Natural antibody in uric acid mediated immune activation and
inflammation (PI) 10/2006-09/2009, Direct cost CAD 106,496/yr
NIH 1R21AI073630-01 The biological relevance of adenosine deamination in immune
activation (PI) 09/2007-08/2009, Direct Cost USD 275, 000/ 2 yrs.
NIH 1R21AI064666-01 Molecular Identification of an Endogenous Adjuvant (PI)
04/2005-03/2007, Direct Cost USD 275, 000/ 2 yrs
Juvenile Diabetes Research Foundation
Dendritic Cells in Autoimmune Diabetes
02/2007-01/2008, Direct Cost USD 100,000/yr
CFI Innovation grant 2006-2011 CAD 146,000
INVITED ADDRESSES
1.
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3.
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7.
8.
Seminar Speaker, University of McMaster. 2010
University of Calgary, Faculty of Medicine Research Day, 2008
University of Calgary, AIG/IRG retreat, 2007
Invited speech: Crystal structures in immune activation. Guest Seminar Series, College of
Pharmacology, University of Kentucky, Lexington, Kentucky, USA September 2005
Seminar: Massachusetts General Hospital, Harvard Medical School, Boston,
Massachusetts. June 2005
Seminar: NIAID, NIH. Washington DC May 2005
Invited speech: Molecular identification of danger factors. Guest Seminar Series, GuyBernier Centre for Research, University of Montreal, Montreal, Canada. May 2005
Invited international scholar: Endogenous Danger Factors. Shanghai Medical University,
Shanghai, China. December 2004
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Yan Shi U of Calgary CV 2011
9.
10.
11.
12.
13.
14.
X.
Invited speech: Endogenous adjuvants in biodefense. National Defense University, Fort
McNair, Washington DC, USA November 2004.
Invited speech: Endogenous adjuvants. Department of Defense DARPA/DSO endogenous
defense workshop. Fairfax, Virginia, USA July 2004.
Seminar. University of Vanderbilt, Nashville, Tennessee. October 2004
Seminar. National Jewish Center, Denver, Colorado. May 2004
Seminar. Yale University, New Haven, Connecticut, March 2004
Seminar. Cornell University, Ithaca, New York, February 2004
PUBLICATIONS
In press
Faranak Ghaemi Oskouie, Afshin Shameli, Ailian Yang. Melanie D. Desrosiers, Ashley D. Mucsi,
Michael R. Blackburn, Yang Yang, Pere Santamaria, and Yan Shi. 2011 High levels of adenosine
deaminase on dendritic cells promote autoreactive T cell activation and diabetes in NOD mice. J
Immunol
Published
1.
Tracy L. Flach, Gilbert Ng, Aswin Hari, Melanie D. Desrosiers, Yin Fong, Ping Zhang, Sandra M.
Ward, Mark E. Seamone, Akosua Vilaysane, Elmar Prenner, Chang Chun Ling, Jurg Tschopp, Daniel A.
Muruve, Matthias W. Amrein, and Yan Shi 2011 Alum interaction with dendritic cell membrane lipids is
essential for its adjuvanticity Nat Med 17:415–416
2.
Faranak Ghaemi-Oskouie and Yan Shi 2011 The role of uric acid as an endogenous danger signal
in immunity and inflammation Cur Rheumatol Rep [Epub ahead of print]
3.
Ping Wang, Wenwen Xu, Björn Petri, Yong Zhang, Wenwen Tang, Le Sun, Holger Kress, Tom
Mann, Yan Shi, Paul Kubes & Dianqing Wu 2010 Important Roles of PIP5K1C in Neutrophil
Recruitment Immunity, 33(3): 340-350,
4.
Hari A, Flach TL, Shi Y, Mydlarski PR. 2010 Toll-like receptors: role in dermatological disease.
Mediators Inflamm. 2010:437246.
5.
Ng G, Chau EM, Shi Y. 2010 Recent developments in immune activation by uric acid crystals.
Arch Immunol Ther Exp . 58(4):273-7.
6.
Shi, Y. 2010 Caught red-handed: uric acid is an agent of inflammation. J Clin
Invest.120(6):1809-11
7.
Unruh TL, Zuccolo J, Beers SA, Kanevets U, Shi Y, Deans JP. 2010 Therapeutic (high) doses of
rituximab activate calcium mobilization and inhibit B-cell growth via an unusual mechanism triggered
independently of both CD20 and Fcgamma receptors. J Immunother. 33(1):30-9
8.
Yang, A., A. D. Mucsi, M. D. Desrosiers, J. F. Chen, J. B. Schnermann, M. R. Blackburn, and Y.
Shi. 2010. Adenosine mediated desensitization of cAMP signaling enhances T-cell responses. Eur J
Immunol 40:449-459.
9.
Shi, Y., A. D. Mucsi, and G. Ng. 2010. Monosodium urate crystals in inflammation and immunity.
Immunol Rev 233:203-217.
10.
Flach TL, Pang W, Chau EM, Desrosiers MD, Shi Y. 2009 Adenosine primes resting stage
dendritic cells before their activation. Biochem Biophys Res Commun. 2009 Mar 20;380(4):748-51. 7.
11.
Kanevets, U., K. Sharma, K. Dresser, and Y. Shi. 2009. A role of IgM antibodies in monosodium
urate crystal formation and associated adjuvanticity. J Immunol 182:1912-1918.
12.
Watanabe A, Sohail MA, Gomes DA, Hashmi A, Nagata J, Sutterwala FS, Mahmood S, Jhandier
MN, Shi Y, Flavell RA, Mehal WZ. 2009 Inflammasome-mediated regulation of hepatic stellate cells.
Am J Physiol Gastrointest Liver Physiol. 296(6):G1248-57.
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Yan Shi U of Calgary CV 2011
13.
Ng, G., K. Sharma, S. M. Ward, M. D. Desrosiers, L. A. Stephens, W. M. Schoel, T. Li, C. A.
Lowell, C. C. Ling, M. W. Amrein, and Y. Shi. 2008. Receptor-independent, direct membrane binding
leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. Immunity 29:807-818.
14.
Ueno A, Wang J, Cheng L, Im JS, Shi Y, Porcelli SA, Yang Y. 2008 Enhanced early expansion
and maturation of semi-invariant NK T cells inhibited autoimmune pathogenesis in congenic nonobese
diabetic mice. J Immunol. 181(10):6789-96.
15.
Wang J, Cho S, Ueno A, Cheng L, Xu BY, Desrosiers MD, Shi Y, Yang Y. 2008 Liganddependent induction of noninflammatory dendritic cells by anergic invariant NKT cells minimizes
autoimmune inflammation. J Immunol. 181(4):2438-45.
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Desrosiers, M. D., K. M. Cembrola, M. J. Fakir, L. A. Stephens, F. M. Jama, A. Shameli, W. Z.
Mehal, P. Santamaria, and Y. Shi. 2007. Adenosine deamination sustains dendritic cell activation in
inflammation. J Immunol 179:1884-1892.
17.
Shi, Y., S. A. Galusha, and K. L. Rock. 2006. Cutting edge: elimination of an endogenous
adjuvant reduces the activation of CD8 T lymphocytes to transplanted cells and in an autoimmune
diabetes model. J Immunol 176:3905-3908.
18.
Chen, C. J., Y. Shi, A. Hearn, K. Fitzgerald, D. Golenbock, G. Reed, S. Akira, and K. L. Rock.
2006. MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by
monosodium urate crystals. J Clin Invest 116:2262-2271.
19.
Rock KL, Hearn A, Chen CJ, Shi Y. 2005 Natural endogenous adjuvants. Springer Semin
Immunopathol. 26(3):231-46.
20.
Shi, Y., J. E. Evans, and K. L. Rock. 2003. Molecular identification of a danger signal that alerts
the immune system to dying cells. Nature 425:516-521.
21.
Shi Y, Rock KL. 2002. Cell death releases endogenous adjuvants that selectively enhance
immune surveillance of particulate antigens. Eur J Immunol. 32(1):155-62.
22.
Shi Y, Lutz CT 2002 Interferon-gamma control of EBV-transformed B cells: a role for CD81 T
cells that poorly kill EBV-infected cells Viral Immunol 15(1):213–225
22.
Shi, Y., W. Zheng, and K. L. Rock. 2000. Cell injury releases endogenous adjuvants that stimulate
cytotoxic T cell responses. Proc Natl Acad Sci U S A 97:14590-14595.
23.
Shi, Y. Smith, K. D. Lutz, C. T. 1998 TAP-independent MHC class I peptide antigen
presentation to alloreactive CTL is enhanced by target cell incubation at subphysiologic temperatures J
Immunol 160(9):4305-12.
24.
Shi, Y. Smith, K. D. Kurilla, M. G. Lutz, C. T. 1997 Cytotoxic CD8+ T cells recognize EBV
antigen but poorly kill autologous EBV-infected B lymphoblasts: immunodominance is elicited by a
peptide epitope that is presented at low levels in vitro J Immunol 159(4):1844-52
25.
Li, Y. Y. Smith, K. D. Shi, Y. Lutz, C. T. 1996 Alloreactive anti-HLA-B7 cytolytic T cell clones
use restricted T cell receptor genes Transplantation 62(7):954-61
In submission
1.
Yan Shi. To force a solid recognition. Trends in Immunology, invited opinion
2.
Ahsan Fayyaz Malik, Gilbert Ng, Fay Munro, Yan Shi, Waj Mehal Development of the foreign
body reaction is dependent on ASC mediated caspsase-1 inflammasome activation PNAS, submitted
3.
Lori Johnson, Uliana Kanevets, Heidi Mulcahy, Yan Shi and Shawn Lewenza DNA-induced
spermidine synthesis contributes to membrane stabilization, resistance to antibiotics and oxidative stress
in Pseudomonas aeruginosa J Bacteriol in revision
Book Chapter
Yan Shi and Melanie D. Desrosiers Adenosine receptor 1 and adenosine deaminase in the regulation of
dendritic cells Recent Development in Immunology, 2008 ISBN: 978-81-7895-375-5 Editor: Jim Xiang
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