Course Name:
Course Number:
Credit Hours:
Pharmaceutical Organic Chemistry-I
700128
3 Hrs. ( 2 Lect. + 1 Pract. )
Course Objectives and Description
The pharmaceutical organic chemistry course is aimed to present the highlights of
organic chemistry and its applications in a brief and suitable manner relation to the
pharmaceutical field of study.
Furthermore, this course provides basic knowledge in general organic chemistry
covering mainly the pharmaceutical organic compounds. It deals with the physical
aspects such as atomic structure, isomerism, hybridization etc., the chemical
reactivity, aliphatic and aromatic hydrocarbons, organic compounds of important
functional groups then the heterocycilic compounds.
Course Contents
1.
2.
3.
4.
5.
6.
Structure and Properties: (6 Hrs.)
Chemical bonding, atomic and molecular orbitals, Covalent bond formation,
hybridization of orbitals, bond dissociation energy, polarity of bonds and
molecules, structure and physical properties, energy changes in chemical
reactions.
Alkanes and Cycloalkanes: (5 Hrs.)
Classification, structure, conformations, nomenclature, physical properties,
preparation, reactions : free radical substitution.
Alicyclic hydrocarbons: Nomenclature, preparation, reactions of small-ring
compounds, conformations of cycloalkanes.
Alkenes and Conjugated Dienes: (4 Hrs.)
Structure, geometric isomerism, nomenclature, physical properties, preparation :
E1 and E2 reactions, reactions : electrophilic addition.
Conjugated Dienes: Structure and properties, resonance, electrophilic
addition, free - radical addition.
Alkynes: (1 Hr.)
Structure, nomenclature, physical properties, preparation, reactions: acidity of
alkynes.
Alkyl halides: (3 Hrs.)
Classification and nomenclature, physical properties, preparation, reactions: SN1
and SN2 reactions.
Alcohols, Ethers and Epoxides: (4 Hrs.)
Classification and nomenclature, physical properties, preparation, reactions,
synthesis using Grignard reagents.
Ethers and Epoxides: Structure and nomenclature, physical properties,
preparation, reactions: cleavage of epoxides.
7.
Aromatic Compounds and Aryl halides: (7 Hrs.)
Structure, stability and resonance, aromaticity: Huckel rule, nomenclature,
electrophilic aromatic substitution: nitration, sulfonation, halogenation, FriedelCrafts alkylation and acylation.
Aryl halides: Structure and nomenclature, physical properties, preparation,
reactions: nucleophilic aromatic substitution.
Text Books For Further Readings:
1)
Morrison and Boyd: Organic Chemistry, New York University, Allyn and
Bacon, Inc. Boston, London, Sydney, Toronto
ISBN 0-205-05838-8
2)
T.W. Solomons: Organic Chemistry, University of South Florida, John Wiley &
Sons, Inc. New York, Chichester, Brisbane, Toronto, Singapore
3)
Zimmerman and Zimmerman: Elements of Organic Chemistry, The City
University of New York, Macmillan Publishing Co. Inc. New York, Collier
Macmillan Publishers, London,
ISBN 0-02-479910-6
4)
Hart, Craine and Hart: Organic Chemistry, A short Course, Houghton Mifflin
Company, Boston Toronto
ISBN 0-395-70838-9
Course Name:
Course Number:
Credit Hours:
Pharmaceutical Organic Chemistry-II
700129
3 Hrs. ( 2 Lect. + 1 Pract. )
Course Objectives and Description
Continuation of Pharmaceutical Organic Chemistry I.
Course Contents
1.
2.
3.
4.
5.
6.
Stereochemistry: (6 Hrs.)
Stereoisomers, enantiomers and optical activity, specific rotation, racemic
mixture, diastereomers and meso compounds, chirality and enontiomerism,
specification of configuration: R, S and D, L systems, reactions involving
stereoisomers, generation of chiral centres, resolution, racemisation,
stereochemistry of addition reactions, stereochemistry of E2 reactions,
stereochemistry of nucleophilic substitution reactions.
Phenols: (3 Hrs.)
Structure and nomenclature, physical properties, preparation, reactions: acidity
of phenols.
Aldehydes and Ketones: (5 Hrs.)
Structure and nomenclature, physical properties, preparation, reactions:
nucleophilic addition, Aldol and Claisen condensations.
Amines: (4 Hrs.)
Structure and classification, nomenclature, physical properties, preparation,
reactions: basicity, rig substitution, diazonium salts, synthesis using diazonium
salts.
Carboxylic Acids and Derivatives of Carboxylic Acids: (5 Hrs.)
Structure and nomenclature, physical properties, preparation, reactions : acidity
of carboxylic acids.
Derivatives of carboxylic acids: Acid chlorides, acid anhydrides, amides,
esters, malonic ester and acetoacetic ester synthesis
Heterocyclic Compounds: (7 Hrs.)
Nomenclature, five - membered rings : structure and properties, six - membered
rings : structure and properties, fused rings : quinoline and isoquinoline.
Text Books For Further Readings:
1)
Morrison and Boyd: Organic Chemistry, New York University, Allyn and
Bacon, Inc. Boston, London, Sydney, Toronto
ISBN 0-205-05838-8
2)
T.W. Solomons: Organic Chemistry, University of South Florida, John Wiley &
Sons, Inc. New York, Chichester, Brisbane, Toronto, Singapore
3)
I.L. Finar: Organic Chemistry, Longman, Scientific & Technical, Copublished
in USA with John Wiley & Sons, Inc. New York.
ISBN 0-582-44257-5
Web Sites:
SITE ADDRESS
1.
http://homework.chem.uic.e
du/IEMDL.HTM
OBJECTIVES
Web site for organic chemistry on-line, a tutorial
consists of a series of short reviews, followed by
problems and exercise on that topic.
2.
A very useful web site. It contains short reviews,
followed by questions with model answers in the
various sections of organic chemistry.
http://www.scientia.org/
cadonlinx/Organic_Chem/
3. http://www.chem.pitt.edu/
~grabowski/Chem0320/
links0320.html
4.
http://www.acdlabs.com/
This web site contains links for generally useful
organic chemistry sites from the University of
Pittsburgh.
Web site to download useful software: ChemSketch
and I-Lab
5.
http://www.acdlabs.com/iup
ac/nomenclature/
Web site of the International Union of Pure and
Applied Chemistry. It details the 1979 and 1993
recommendations for nomenclature of organic
chemistry
6.
http://www.lib.utexas.edu/Li
bs/Chem/
Chemistry library at University of Texas at Austin, with
a link to Chemical Abstracts and other useful web
sites.