Organismal Biology 1030 A & B, Section Two Exam, Spring 2010 1. In Griffith's experiment demonstrating that Streptococcus pneumoniae bacteria can transfer genetic information, the reason that the type "S" strain could infect mice and cause pneumonia was because: A. They had flagella as a means of movement, whereas the “R” did not B. They reproduced much faster than type "R" bacteria, due to a superior DNA polymerase C. They produced a smooth polysaccharide capsule (coat) that helps them evade the mouse’s immune system D. The type “R” bacteria had all been killed by subjecting them to a high temperature E. They did not cause pneumonia in the mice, the type “R” strain did 2. Hershey and Chase showed that the virus T4: A. Injects protein into a bacterium B. Injects polysaccharide into a bacterium C. Injects protein and DNA into a bacterium D. Injects RNA into a bacterium E. Injects DNA into a bacterium 3. Chargaff showed that DNA contains equal amounts of adenine and: A. Thymine B. Uracil C. Guanine D. Cytosine E. Threonine 4. The four nitrogen bases that are found in the different nucleotides of DNA are: A. Adenine, thymine, cytosine, uracil B. Adenine, thymine, cytosine, guanine C. Uracil, adenine, cytosine, guanine D. Uracil, cytosine, guanine, thymine E. Alanine, threonine, cysteine, glycine 5. DNA's base pairs are joined by: A. Hydrogen bonds B. Covalent bonds C. Ionic bonds D. Strong bonds E. Peptide bonds 6. The genome of an organism is all of its: A. Proteins B. Genetic material (DNA) C. Transcribed RNA D. Visible characteristics E. Cells 7. In eukaryotic cells DNA is not found in the: A. Nucleus B. Mitochondria C. Chloroplasts D. Ribosomes E. Chromosomes 8. A sequence of DNA nucleotides coding for a specific protein or structural or catalytic RNA molecule is a: A. Gene B. Genome C. Chromosome D. Chromatid E. Nucleosome 1 9. The process by which DNA reproduces itself is: A. Protein synthesis B. Aerobic respiration C. Substrate-level phosphorylation D. Replication E. Photosynthesis 10. DNA replication is: A. Conservative B. A one-step process C. Not carried out by enzymes D. Semi-conservative E. Not carried out in Bacterial or Archaeal cells 11. The enzyme that adds nucleotides to form new strands of DNA is: A. Primase B. DNA polymerase C. ATP synthase D. Ligase E. Helicase 12. A mutation can not: A. Eliminate the ability of a protein to function B. Alter the functional ability of a protein C. Improve the function of a protein D. Interfere with the transcription of a gene E. Be passed on to future generations, if it occurs in a somatic cell 13. Requirements for the polymerase chain reaction (PCR) do not include: A. A target DNA sequence sample to be replicated B. A heat tolerant DNA polymerase such as taq C. A supply of the four different DNA nucleotides D. Two types of short, laboratory-made primers of defined sequence E. Knowledge of the complete DNA sequence to be replicated 14. The polymerase chain reaction can not be used to: A. Solve crimes based on biological evidence B. Establish genetic (including parental) relationships C. Identify the remains of dead organisms (including people) D. Identify disease-causing genes or pathogens E. Cure global warming 15. If one strand of a DNA molecule has the base sequence of ATGTGCC the complementary strand will read: A. ATGTGCC B. UACACGG C. CGTGTAA D. TACACGG E. Gee, you look great today 16. Apoptosis is also called: A. Replication B. Mitosis C. The cell cycle D. Programmed cell death E. Programmed cellular reproduction 2 17. Before a cell divides, it must first duplicate its entire ______________: A. Genome B. Cytoplasmic contents C. Cell membrane structure D. Array of enzymes E. Phenotype 18. A discreet package of DNA and associated proteins in eukaryotes is a: A. Nucleus B. Ribosome C. Chromosome D. Golgi body E. Centromere 19. A nucleosome consists of: A. A defined stretch of DNA B. A defined stretch of RNA C. A ribosome and mRNA D. A defined stretch of RNA and histones E. A defined stretch of DNA and histones 20. One of two identical attached copies of a replicated chromosome defines the term: A. Centromere B. Chromatin C. Chromosome D. Chromatid E. Nucleosome 21. A part of a chromosome that attaches sister chromatids to each other defines the term: A. Centromere B. Chromatin C. Nucleosome D. Histone E. Telomere 22. A cell with two full sets of chromosomes would be termed a _______________ cell. A. Haploid B. Diploid C. Sister D. Somatic E. Germ 23. A cell with one full set of chromosomes would be termed a ________________ cell. A. Haploid B. Diploid C. Sister D. Somatic E. Germ 24. The single pair of unmatched chromosomes in humans: A. Are not the sex chromosomes B. Are not the "X" and "Y" chromosomes C. Contain entirely different genes D. Do not determine sex (gender) of humans E. Are autosomes 3 25. The process by which a sperm cell combines with an egg cell is: A. Recombination B. Replication C. Mitosis D. Fertilization E. Germination 26. If a sperm cell combines with an egg cell, the result is a(n): A. Gamete B. Germ cell C. Zygote D. Duplicated chromosome E. Omelette 27. Examples of a haploid cells do not include: A. Sperm cells B. Gametes C. Egg cells D. Zygotes E. Plant spores 28. In humans, specialized cells that produce gametes are: A. Somatic cells B. Sperm cells C. Egg cells D. Germ cells E. Gametophytes 29. In humans, cells that do not produce gametes are collectively called: A. Somatic cells B. Sperm cells C. Egg cells D. Germ cells E. Gametophytes 30. The actual splitting of a cell into two daughter cells in the cell cycle is: A. Mitosis B. Interphase C. Metaphase D. Anaphase E. Cytokinesis 31. The division of the nucleus itself during the cell cycle is: A. Mitosis B. Interphase C. Metaphase D. Anaphase E. Cytokinesis 32. The replication of a cell’s DNA during the cell cycle occurs during: A. Mitosis B. Interphase C. Metaphase D. Anaphase E. Cytokinesis 4 33. The correct sequence for the phases of mitosis is: A. Interphase - prophase - telophase - metaphase - anaphase B. Interphase - metaphase - anaphase - prophase - telophase C. Prophase - metaphase - anaphase - telophase D. Anaphase - prophase - metaphase - telophase E. Prophase - anaphase - telophase - metaphase 34. The portion of the cytoskeleton that enables the chromosomes to be separated equally into two sets is the: A. Golgi body B. Centromere C. Pilus D. Endoplasmic reticulum E. Mitotic spindle 35. The phase of mitosis when the centromeres split and sister chromatids are pulled to opposite poles of the cell is: A. Prophase B. Interphase C. Metaphase D. Anaphase E. Telophase 36. The phase of mitosis in which the chromosomes are aligned along the equator of the cell is: A. Prophase B. Interphase C. Metaphase D. Anaphase E. Telophase 37. The phase of mitosis in which the chromosomes condense and centrosomes move to opposite poles of the cell is: A. Prophase B. Interphase C. Metaphase D. Anaphase E. Telophase 38. Meiosis is a process that does not produce: A. Sperm cells B. Egg cells C. Gametes D. Haploid cells E. Zygotes 39. The process by which a bacterium uses a sex pilus to transfer genetic information to another bacterium is: A. Recombination B. Conjugation C. Apotosis D. Mitosis E. Replication 40. Sexual reproduction is important to the survival of a species in a changing environment because: A. Sexual reproduction requires less overall energy expenditure than asexual reproduction B. Sexual reproduction requires only one individual C. Sexual reproduction produces genetically identical individuals D. Sexual reproduction produces genetically different individuals E. Sexual reproduction is fun 5 41. If human gametes were diploid: A. The products of fertilization would have the same number of chromosomes as their parents B. The products of fertilization would have more chromosomes than their parents C. The products of fertilization would have fewer chromosomes than their parents D. Fertilization could not occur E. Human infants could fly 42. A diploid germ cell reduces its chromosome number by half to generate four haploid nuclei in: A. Fertilization B. Mitosis C. Meiosis D. Replication E. Interphase 43. A zygote is: A. A haploid cell B. A gamete C. The first diploid cell of a new organism D. A product of meiosis E. A product of mitosis 44. Human cell's have: A. 22 pairs of chromosomes B. 23 pairs of chromosomes C. 45 chromosomes D. 2 pairs of sex chromosomes E. One pair of autosomes 45. The human chromosomes that do not determine whether an individual is male or female are: A. Not found in homologous pairs B. The autosomes C. The "X" and "Y" chromosomes D. Called the sex chromosomes E. Somatic 46. The ‘normal’ chromosomal designation for a human male is: A. "XX" B. "XO" C. "XY" D. "YY" E. "XXX" 47. The ‘normal’ chromosomal designation for a human female is: A. "XX" B. "XYY" C. "XY" D. "YY" E. "XO" 48. Chromosomes that look alike and carry the same sequence of genes for the same traits are: A. The "X" and "Y" chromosome B. All the autosomes C. Found in females only D. Found in males only E. Homologous chromosomes 6 49. In meiosis, DNA replicates only during: A. Prophase one B. Prophase two C. Interphase one D. Interphase two E. Metaphase two 50. In meiosis, homologous chromosomes separate during: A. Prophase one B. Prophase two C. Metaphase one D. Anaphase one E. Anaphase two 51. In meiosis, paired homologous chromosomes align down the center of the cell during: A. Prophase one B. Prophase two C. Metaphase one D. Metaphase two E. Anaphase two 52. In meiosis, chromosomes containing sister chromatids (not homologous chromosomes) align along the equatorial center of the cell during: A. Prophase one B. Prophase two C. Interphase two D. Metaphase one E. Metaphase two 53. In meiosis, the separated sister chromatids move to opposite poles of the cell during: A. Metaphase one B. Metaphase two C. Anaphase one D. Anaphase two E. Telophase one 54. In meiosis two, cytokinesis results in the production of: A. Four haploid daughter cells B. Two haploid daughter cells C. Four diploid daughter cells D. Two diploid daughter cells E. One daughter cell identical to the parent cell that underwent meiosis 55. Sexual reproduction and meiosis do not generate significant genetic variety through: A. Random fertilization B. Independent assortment C. Crossing over (a.k.a. homologous recombination) D. Law of segregation E. DNA replication 56. Alternate forms of the same gene: A. Do not exist B. Are homologous C. Are alleles D. Are sister chromatids E. Do not occur in the same individual 7 57. A healthy young couple are both carriers of cystic fibrosis, a Mendelian-style, simple recessive trait, the chance that each of their future children will inherit this serious illness is: A. No chance, because cystic fibrosis is not an inherited illness B. 10% C. 25% D. 50% E. 100% 58. An allele that exerts its effects whenever it is present is: A. Dominant B. Recessive C. Homologous D. Homozygous E. Heterozygous 59. When Mendel crossed short pea plants with short pea plants the offspring: A. Were always short B. Were always tall C. Were always a mix of short and tall D. Were sometimes tall, but sometimes a mix of tall and short E. Did not grow and reproduce 60. When Mendel crossed tall plants with tall plants the offspring: A. Were always short B. Were always tall C. Were always a mix of short and tall D. Were sometimes tall, but sometimes a mix of tall and short E. Did not grow and reproduce 61. If the two alleles for a particular gene are identical the gene pair is: A. Homologous B. Heterozygous C. Homozygous D. Dominant E. Recessive 62. If the two alleles for a particular gene are different, the gene pair is: A. Homologous B. Heterozygous C. Homozygous D. Dominant E. Recessive 63. If an individual is heterozygous for a particular trait: A. Each parent contributed a different allele for that trait B. Each parent contributed the same allele for that trait C. Only one parent contributed an allele of that gene, the other contributed no alleles of that gene D. Two different genes contribute to the trait E. That particular trait insures that the individual is heterosexual 64. Phenotype means: A. The number of gametes in an individual B. The number of chromosomes in an individual C. The observable expression of the genes in an individual D. The combination of alleles in an individual E. The arranged image of all the individual’s stained prophase stage chromosomes 8 65. A monohybrid cross is a mating between two individuals that are both: A. Heterozygous for one gene B. Homozygous for one gene C. Heterozygous for two genes D. Homozygous for two genes E. Hemizygous for one gene 66. Mendel's monohybrid cross of "Tt" (T for tall, t for short) parents resulted in a tall to short ratio of: A. 1:1 B. 1:2 C. 2:1 D. 3:1 E. 1:3 67. A dihybrid cross is a mating between two individuals that are each ____________ for _________ gene(s). A. Homozygous, one B. Homozygous, two C. Homologous, two D. Heterozygous, one E. Heterozygous, two 68. In the ABO blood type system the IA and IB alleles: A. Are recessive B. Are codominant C. Only one is expressed when both are present D. Have incomplete dominance E. Are completely different genes 69. If the heterozygous phenotype is intermediate between those of the two different homozygotes, this is called: A. Codominance B. Incomplete dominance C. Independent assortment D. Epistasis E. Polygenic 70. Traits that depend on more than one gene are: A. Pleiotropic B. Polygenic C. Codominant D. Recessive E. Incomplete dominant traits 71. Which major characteristic is not used to uniquely identify each chromosome in a karyotype? A. Banding pattern after staining B. Overall size C. Centromere position D. p and q arm lengths E. Telomere length 72. Linked genes, by definition, are genes that: A. Have no alleles B. Are found in the same species C. Are found close to each other on the same chromosome D. Have more alleles than usual E. Are alleles that are found in different daughter cells 9 73. If any of the traits that Mendel worked with had been due to linked genes, his dihybrid crosses: A. Would have produced sterile offspring B. Would have produced more offspring C. Would have produced less offspring D. Would have exhibited a phenotypic ratio of 9:3:3:1 E. Would have exhibited a phenotypic ratio of 3:1 74. A dihybrid cross of unlinked genes theoretically gives a phenotypic ratio: A. Of 9:3:3:1 B. Of 1:1 C. Of 2:1 D. Of 3:1 E. That is the same as that for genes that are linked 75. Crossing over is more likely to separate genes on a chromosome, if they are: A. Close together B. Recessive genes C. Far apart D. Dominant genes E. Mutated genes 76. To inherit an autosomal dominant disorder, a person could receive the disease causing allele from: A. The father only, not the mother B. The mother only, not the father C. The parent who does not exhibit the disease D. The mother or the father, whichever exhibits the disease E. Any of the four grandparents 77. To inherit an autosomal recessive disorder requires a person to receive the disease causing allele from: A. The father only, not the mother B. The mother only, not the father C. Only the parent that exhibits the disease D. Only one parent who is homozygous recessive for the disease E. Both parents 78. As seen in the video on sex determination, androgen insensitivity syndrome is a good example of: A. Epistasis B. Pleiotropy C. Incomplete dominance D. A polygenic trait E. Codominance 79. The chromosome that plays the largest role in human male sex determination is: A. The "X" chromosome B. Chromosome number 21 C. The "Y" chromosome D. All of the autosomes E. The "X" and "Y" chromosome are equally responsible 80. A male expresses: A. Only the dominant alleles on his "X" chromosome B. Only the recessive alleles on his "X" chromosome C. Both the dominant and recessive alleles on his "X" chromosome D. None of the alleles on his "X" chromosome E. A male doesn’t have a "X" chromosome 10 81. In a molecule of DNA: A. Adenine pairs with thymine B. Cytosine pairs with adenine C. Thymine pairs with uracil D. Adenine pairs with uracil E. Guanine pairs with thymine 82. The "Central Dogma" of molecular biology does not refer to: A. The flow of genetic information in cells B. Genetic information passing from DNA to RNA by transcription C. Genetic information passing from RNA to protein by translation D. All organisms have evolved from preexisting life E. Information cannot be transferred back from protein to either protein or nucleic acid 83. DNA differs from RNA in that: A. DNA contains uracil B. DNA can catalyze chemical reactions C. DNA contains thymine D. DNA is usually single stranded E. DNA contains ribose 84. The type of RNA that carries the information that specifies a protein is: A. Messenger RNA (mRNA) B. Transfer RNA (tRAN) C. Ribosomal RNA (rRNA) D. The 5’ cap E. The poly-A tail 85. The type of RNA that helps align the ribosome and mRNA, and catalyzes the reaction that creates the peptide bond is: A. Messenger RNA (mRNA) B. Transfer RNA (tRAN) C. Ribosomal RNA (rRNA) D. The 5’ cap E. The poly-A tail 86. The type of RNA that carries each amino acid to the ribosome is: A. Messenger RNA (mRNA) B. Transfer RNA (tRNA) C. Ribosomal RNA (rRNA) D. The 5’ cap E. The poly-A tail 87. A DNA sequence that signals a gene's start is: A. A codon B. An anticodon C. A terminator D. An amino acid attachment site E. A promoter 88. The process used by cells to convert the mRNA "message" into a sequence of amino acids is: A. Transcription B. Translation C. Replication D. Mitosis E. Amino acid synthesis 11 89. A three base sequence (loop) in tRNA that is complementary to a sequence of three bases in mRNA is: A. An anticodon B. A codon C. A promoter D. A terminator E. An amino acid attachment site 90. A tRNA molecule is "bilingual" because it binds to: A. Amino acids and DNA B. DNA and mRNA codons C. Codons of mRNA and amino acids D. Promoters and amino acids E. Promoters and terminators 91. The first step of translation in which an mRNA, a small ribosomal subunit, and the initiator tRNA are aligned together is: A. Mitosis B. Initiation C. Elongation D. Termination E. Transcription 92. The middle step of translation in which amino acids are added one at a time to the growing polypeptide is: A. Mitosis B. Initiation C. Elongation D. Termination E. Transcription 93. The last step of translation in which release factors bind to a stop codon is: A. Mitosis B. Initiation C. Elongation D. Termination E. Transcription 94. A group of genes and other segments of DNA in Bacteria that are controlled together is: A. A proteome B. A chromosome C. A ribosome D. An operon E. A replication fork 95. In the Lac operon, the protein that binds to the operator to prevent transcription is: A. RNA polymerase B. DNA polymerase C. The repressor D. The promoter E. Lactose 96. Proteins that initiate transcription in eukaryotes by recognizing sequences within the promoter region of a gene and attracting RNA polymerase are: A. Repressors B. Transcription factors C. Inducers D. TATA boxes E. Poly A Tails 12 97. Any change in a cell's DNA sequence is: A. Replication B. Transcription C. Translation D. An operon E. A mutation 98. In a "missense" (nonsynonymous) mutation in an exon: A. The codon that mutates does not cause a change in the amino acid specified B. The codon that mutates causes a change in the amino acid specified C. The codon that mutates causes a stop codon to occur instead of the placement of an amino acid D. The addition of any number of nucleotides (bases) in multiples of three destroys the protein's function E. The deletion of any number of nucleotides (bases) in multiples of three destroys the protein's function 99. In a "silent" (synonymous) mutation that occurs in an exon: A. The codon that mutates does not cause a change in the amino acid specified B. The codon that mutates causes a change in the amino acid specified C. The codon that mutates causes a stop codon to occur instead of the placement of an amino acid D. The addition of any number of nucleotides (bases) in multiples of three preserves the protein's function E. The deletion of any number of nucleotides (bases) in multiples of three preserves the protein's function 100. Which statement does not apply to a "frameshift" mutation: A. It may be caused by an addition of any number of nucleotides (bases) not in multiples of three B. It may be caused by a deletion of any number of nucleotides (bases) not in multiples of three C. It always disrupts the reading frame of a gene D. It almost always destroys a protein's ability to function E. It usually does not harm a protein's ability to function 13 Organismal Biology Section Two Exam Key (warning – some questions differ from above with different answers) 1. In Griffith's experiment demonstrating that bacteria can transfer genetic information, the reason that the type "S" strain could infect mice and cause pneumonia was because: A. B. C. D. E. They had flagella as a means of movement They reproduced much faster than type "R" bacteria They produced a polysaccharide capsule (coat) All of the above are correct None of the above are correct Difficulty Level: Moderate Hoefnagels - Chapter 07 #9 Question Type: Comprehension 2. Hershey and Chase showed that the virus T4: A. Injects protein into a bacterium B. Injects polysaccharide into a bacterium C. Injects protein and DNA into a bacterium D. Injects RNA into a bacterium E. Injects DNA into a bacterium Difficulty Level: Moderate Hoefnagels - Chapter 07 #11 Question Type: Comprehension 3. Chargaff showed that DNA contains equal amounts of adenine and: A. Thymine B. Uracil C. Guanin e D. Cytosin e E. Threonin e Difficulty Level: Low Hoefnagels - Chapter 07 #13 Question Type: Knowledge 1 4. The four nitrogen bases that are found in the different nucleotides of DNA are: A. Adenine, thymine, cytosine, uracil B. Adenine, thymine, cytosine, guanine C. Uracil, adenine, cytosine, guanine D. Uracil, cytosine, guanine, thymine E. None of the above are correct Difficulty Level: Moderate Hoefnagels - Chapter 07 #15 Question Type: Knowledge 5. DNA's base pairs are joined by: A. B. C. D. E. Hydrogen bonds Covalent bonds Ionic bonds All the above are correct None of the above are correct Difficulty Level: Moderate Hoefnagels - Chapter 07 #17 Question Type: Comprehension 6. The genome of an organism is all of its: A. Protein s B. Genetic material C. RNA D. Characteristic s E. All of the above are correct Difficulty Level: Low Hoefnagels - Chapter 07 #22 Question Type: Knowledge 2 7. In eukaryotic cells DNA is found in the: A. Nucleu s B. Mitochondri a C. Chloroplast s D. All of the above are correct E. None of the above are correct Difficulty Level: Low Hoefnagels - Chapter 07 #23 Question Type: Knowledge 8. A sequence of DNA nucleotides coding for a specific protein or RNA molecule is a: A. Gen e B. Genom e C. Chromosom e D. All of the above are correct E. None of the above are correct Difficulty Level: Low Hoefnagels - Chapter 07 #26 Question Type: Knowledge 9. The process by which DNA reproduces itself is: A. Protein synthesis B. Aerobic respiration C. Substratephosphorylation D. Replicatio n E. Photosynthesi s Difficulty Level: Low Hoefnagels - Chapter 07 #29 Question Type: Knowledge 3 10. DNA replication is: A. Conservativ e B. A one-step process C. Not carried out by enzymes D. Semiconservative E. Not carried out in prokaryotic cells Difficulty Level: Low Hoefnagels - Chapter 07 #30 Question Type: Knowledge 11. The enzyme that adds nucleotides to form new strands of DNA is: A. Primas e B. DNA polymerase C. ATP synthase D. Ligas e E. Helicas e Difficulty Level: Low Hoefnagels - Chapter 07 #34 Question Type: Knowledge 12. A mutation may: A. Eliminate the ability of a protein to function B. Not alter the functional ability of a protein C. Improve the function of a protein D. All of the above are correct E. None of the above are correct Difficulty Level: Moderate Hoefnagels - Chapter 07 #35 Question Type: Comprehension 4 13. Requirements for polymerase chain reaction tests include: A. A target DNA sequence to be replicated B. A heat tolerant DNA polymerase C. A supply of the four different DNA nucleotides D. Two types of short, laboratory-made primers E. All of the above are correct Difficulty Level: Low Hoefnagels - Chapter 07 #38 Question Type: Comprehension 14. Polymerase chain reaction may be used to: A. Identify missing persons B. Establish genetic relationships C. Identify remains D. Identify disease-causing genes E. All of the above are correct Difficulty Level: Low Hoefnagels - Chapter 07 #39 Question Type: Comprehension 15. If one strand of a DNA molecule has the base sequence of ATGTGCC the complementary strand will read: A. B. C. D. E. ATGTGCC UACACGG CGTGTAA TACACGG None of the above are correct Difficulty Level: Moderate Hoefnagels - Chapter 07 #41 Question Type: Application 5 16. Apoptosis is also called: A. Replicatio n B. Mitosis C. The cell cycle D. Programmed cell death E. Programmed cellular reproduction Difficulty Level: Low Hoefnagels - Chapter 08 #1 Question Type: Knowledge 17. Before a cell divides, it must first duplicate its entire ______________: A. Genom e B. Cytoplasmic contents C. Cell membrane structure D. Array of enzymes E. All of the above are correct Difficulty Level: Moderate Hoefnagels - Chapter 08 #3 Question Type: Comprehension 18. A discreet package of DNA and associated proteins in eukaryotes is a: A. Nucleu s B. Ribosom e C. Chromosom e D. Golgi body E. None of the above are correct Difficulty Level: Low Hoefnagels - Chapter 08 #4 Question Type: Knowledge 6 19. A nucleosome consists of: A. A stretch of DNA B. An RNA molecule C. A ribosome and RNA D. Histone s E. A stretch of DNA and histones Difficulty Level: Moderate Hoefnagels - Chapter 08 #6 Question Type: Knowledge 20. One of two identical attached copies of a replicated chromosome defines the term: A. Centromer e B. Chromati n C. Chromosom e D. Chromati d E. Nucleosom e Difficulty Level: Moderate Hoefnagels - Chapter 08 #8 Question Type: Knowledge 21. A part of a chromosome that attaches sister chromatids to each other defines the term: A. Centromer e B. Chromati n C. Nucleosom e D. Histone E. None of the above are correct Difficulty Level: Moderate Hoefnagels - Chapter 08 #9 Question Type: Knowledge 7 22. A cell with two full sets of chromosomes would be termed a _______________ cell. A. Haploid B. Diploid C. Siste r D. Somati c E. Germ Difficulty Level: Low Hoefnagels - Chapter 08 #13 Question Type: Knowledge 23. A cell with one set of chromosomes would be termed a ________________ cell. A. Haploid B. Diploid C. Siste r D. Somati c E. None of the above are correct Difficulty Level: Low Hoefnagels - Chapter 08 #14 Question Type: Knowledge 24. The pair of unmatched chromosomes in humans: A. Are the sex chromosomes B. Are the "X" and "Y" chromosomes C. Contain different genes D. Determine sex (gender) of humans E. All of the above are correct Difficulty Level: Low Hoefnagels - Chapter 08 #15 Question Type: Comprehension 25. The process by which a sperm cell combines with an egg cell is: A. Recombinatio n B. Replicatio n C. Mitosis D. Fertilizatio n E. Germinatio n Difficulty Level: Low Hoefnagels - Chapter 08 #16 Question Type: Knowledge 8 26. If a sperm cell combines with an egg cell the result is a: A. Gamet e B. Haploid cell C. Diploid cell D. Duplicated chromosome E. None of the above are correct Difficulty Level: Moderate Hoefnagels - Chapter 08 #17 Question Type: Application 27. An example of a haploid cell is: A. A sperm cell B. A gamete C. An egg cell D. All of the above are correct E. None of the above are correct Difficulty Level: Low Hoefnagels - Chapter 08 #18 Question Type: Application 28. In humans, specialized cells that produce gametes are: A. Somatic cells B. Sperm cells C. Egg cells D. Germ cells E. None of the above are correct Difficulty Level: Low Hoefnagels - Chapter 08 #19 Question Type: Knowledge 9 29. In humans, cells that do not produce gametes are collectively called: A. Somatic cells B. Sperm cells C. Egg cells D. Germ cells E. None of the above are correct Difficulty Level: Low Hoefnagels - Chapter 08 #20 Question Type: Knowledge 30. The splitting of a cell into two daughter cells in the cell cycle is: A. Mitosis B. Interphas e C. Metaphas e D. Anaphas e E. Cytokinesi s Difficulty Level: Low Hoefnagels - Chapter 08 #26 Question Type: Knowledge 31. The division of the nucleus during the cell cycle is: A. Mitosis B. Interphas e C. Synthesi s D. Cytokinesi s E. Replicatio n Difficulty Level: Low Hoefnagels - Chapter 08 #27 Question Type: Knowledge 10 32. The replication of DNA during the cell cycle occurs during: A. Mitosis B. Interphas e C. Cytokinesi s D. Prophas e E. Telophas e Difficulty Level: Low Hoefnagels - Chapter 08 #28 Question Type: Knowledge 33. The correct sequence for the phases of mitosis is: A. B. C. D. E. Interphase - prophase - telophase - metaphase anaphase Interphase - metaphase - anaphase - prophase telophase Prophase - metaphase - anaphase telophase Anaphase - prophase - metaphase telophase Prophase - anaphase - telophase metaphase Difficulty Level: Moderate Hoefnagels - Chapter 08 #30 Question Type: Comprehension 34. The portion of the cytoskeleton that enables the chromosomes to be separated equally into two sets is the: A. Golgi body B. Centromer e C. Centrosom e D. Kinetochor e E. Mitotic spindle Difficulty Level: Moderate Hoefnagels - Chapter 08 #31 Question Type: Comprehension 11 35. The phase of mitosis in which the centromeres split and sister chromatids are pulled to opposite poles of the cell is: A. Prophas e B. Prometapha se C. Metaphas e D. Anaphas e E. Telophas e Difficulty Level: Moderate Hoefnagels - Chapter 08 #35 Question Type: Comprehension 36. The phase of mitosis in which the chromosomes are aligned along the equator of the cell is: A. Prophas e B. Prometapha se C. Metaphas e D. Anaphas e E. Telophas e Difficulty Level: Moderate Hoefnagels - Chapter 08 #36 Question Type: Comprehension 37. The phase of mitosis in which the chromosomes condense and centrosomes move to opposite poles of the cell is: A. Prophas e B. Prometapha se C. Metaphas e D. Anaphas e E. Telophas e Difficulty Level: Moderate Hoefnagels - Chapter 08 #38 Question Type: Comprehension 12 38. Meiosis is a process that produces: A. Sperm cells B. Egg cells C. Gamete s D. Haploid cells E. All of the above are correct Difficulty Level: Low Hoefnagels - Chapter 09 #1 Question Type: Comprehension 39. The process by which a bacterium uses a sex pilus to transfer genetic information to another bacterium is: A. Parthenogene sis B. Conjugatio n C. Apomixis D. Mitosis E. Replicatio n Difficulty Level: Moderate Hoefnagels - Chapter 09 #2 Question Type: Knowledge 40. Sexual reproduction is important to the survival of a species in a changing environment because: A. B. C. D. E. Sexual reproduction requires less overall energy expenditure than asexual reproduction Sexual reproduction requires only one individual Sexual reproduction produces genetically identical individuals Sexual reproduction produces genetically different individuals None of the above are correct Difficulty Level: Moderate Hoefnagels - Chapter 09 #3 Question Type: Comprehension 13 41. If human gametes were diploid: A. The products of fertilization would have the same number of chromosomes as their parents B. The products of fertilization would have more chromosomes than their parents C. The products of fertilization would have fewer chromosomes than their parents D. Fertilization could not occur E. None of the above are correct Difficulty Level: Moderate Hoefnagels - Chapter 09 #7 Question Type: Application 42. A diploid germ cell reduces its chromosome number by half to generate four haploid nuclei in: A. Fertilizatio n B. Mitosis C. Meiosis D. Replicatio n E. Parthenogene sis Difficulty Level: Moderate Hoefnagels - Chapter 09 #10 Question Type: Comprehension 43. A zygote is: A. B. C. D. E. A haploid cell A gamete The first diploid cell of a new organism A product of meiosis All the above are correct Difficulty Level: Low Hoefnagels - Chapter 09 #13 Question Type: Knowledge 14 44. Human cell's have: A. 22 pairs of chromosomes B. 23 pairs of chromosomes C. 44 chromosomes D. 2 pairs of sex chromosomes E. One pair of autosomes Difficulty Level: Low Hoefnagels - Chapter 09 #17 Question Type: Knowledge 45. The human chromosomes that do not determine whether an individual is male or female are: A. Not found in pairs B. Autosome s C. The "X" and "Y" chromosomes D. Called sex chromosomes E. None of the above are correct Difficulty Level: Low Hoefnagels - Chapter 09 #19 Question Type: Knowledge 46. The chromosomal designation for a human male is: A. B. C. D. E. "XX" "XO" "XY" "YY" "XXX" Difficulty Level: Low Hoefnagels - Chapter 09 #20 Question Type: Knowledge 47. The chromosomal designation for a human female is: A. B. C. D. E. "XX" "XYY" "XY" "YY" None of the above are correct Difficulty Level: Low Hoefnagels - Chapter 09 #21 Question Type: Knowledge 15 48. Chromosomes that look alike and carry the same sequence of genes for the same traits are: A. The "X" and "Y" chromosome B. All the autosomes C. Found in females only D. Found in males only E. Homologous chromosomes Difficulty Level: Moderate Hoefnagels - Chapter 09 #22 Question Type: Knowledge 49. In meiosis, DNA replicates during: A. B. C. D. E. Prophase one Prophase two Interphase one Interphase two Metaphase two Difficulty Level: Moderate Hoefnagels - Chapter 09 #28 Question Type: Comprehension 50. In meiosis, homologous chromosomes separate during: A. Prophase one B. Prophase two C. Metaphase one D. Anaphase one E. Anaphase two Difficulty Level: Moderate Hoefnagels - Chapter 09 #30 Question Type: Comprehension 16 51. In meiosis, paired homologs align down the center of the cell during: A. Prophase one B. Prophase two C. Metaphase one D. Metaphase two E. Anaphase two Difficulty Level: Moderate Hoefnagels - Chapter 09 #32 Question Type: Comprehension 52. In meiosis, chromosomes containing sister chromatids (not homologous chromosomes) align along the center of the cell during: A. Prophase one B. Prophase two C. Interphase two D. Metaphase one E. Metaphase two Difficulty Level: Moderate Hoefnagels - Chapter 09 #33 Question Type: Comprehension 53. In meiosis, the separated sister chromatids move to opposite poles of the cell during: A. Metaphase one B. Metaphase two C. Anaphase one D. Anaphase two E. Telophase one Difficulty Level: Moderate Hoefnagels - Chapter 09 #34 Question Type: Comprehension 17 54. In meiosis two, cytokinesis results in the production of: A. Four haploid daughter cells B. Two haploid daughter cells C. Four diploid daughter cells D. Two diploid daughter cells E. One daughter cell identical to the parent cell that underwent meiosis Difficulty Level: Moderate Hoefnagels - Chapter 09 #35 Question Type: Comprehension 55. Sexual reproduction and meiosis generates genetic variety by: A. B. C. D. E. Random fertilization Independent assortment Crossing over All of the above are correct None of the above are correct Difficulty Level: Low Hoefnagels - Chapter 09 #36 Question Type: Comprehension 56. Alternate forms of the same gene: A. Do not exist B. Are homologs C. Are alleles D. Are sister chromatids E. Do not occur in the same individual Difficulty Level: Low Hoefnagels - Chapter 09 #38 Question Type: Knowledge 18 57. A healthy young couple are both carriers of cystic fibrosis, a simple recessive trait, the chance that each of their future children will inherit this serious illness is: A. No chance, because cystic fibrosis is not an inherited illness B. 10% C. 25% D. 50% E. 100% Difficulty Level: Low Hoefnagels - Chapter 10 #3 Question Type: Knowledge 58. An allele that exerts its effects whenever it is present is: A. Dominan t B. Recessiv e C. Homologou s D. Homozygou s E. Heterozygou s Difficulty Level: Low Hoefnagels - Chapter 10 #14 Question Type: Knowledge 59. When Mendel crossed short pea plants with short pea plants the offspring: A. Were all tall B. Were all short C. Were a mix of tall and short D. Were nonexistent E. None of the above are correct Difficulty Level: Low Hoefnagels - Chapter 10 #15 Question Type: Knowledge 19 60. When Mendel crossed tall plants with tall plants the offspring: A. Were always short B. Were always tall C. Were always a mix of short and tall D. Were sometimes tall, but sometimes a mix of tall and short E. Did not grow and reproduce Difficulty Level: Moderate Hoefnagels - Chapter 10 #16 Question Type: Knowledge 61. If the two alleles for a particular gene are identical the gene pair is: A. Homologou s B. Heterozygou s C. Homozygou s D. Dominan t E. Recessiv e Difficulty Level: Moderate Hoefnagels - Chapter 10 #17 Question Type: Knowledge 62. If the two alleles for a particular gene are different the gene pair is: A. Homologou s B. Heterozygou s C. Homozygou s D. Dominan t E. Recessiv e Difficulty Level: Moderate Hoefnagels - Chapter 10 #18 Question Type: Knowledge 20 63. If an individual is heterozygous for a particular trait: A. Each parent contributed a different gene for that trait B. The alleles for that trait are the same C. Each parent contributed the same gene for that trait D. Both B and C are correct E. None of the above are correct Difficulty Level: Moderate Hoefnagels - Chapter 10 #19 Question Type: Comprehension 64. Phenotype means: A. The number of gametes in an individual B. The number of chromosomes in an individual C. The observable expression of the genes in an individual D. The combination of alleles in an individual E. None of the above are correct Difficulty Level: Moderate Hoefnagels - Chapter 10 #24 Question Type: Knowledge 65. A monohybrid cross is a mating between two individuals that are both: A. Heterozygous for one gene B. Homozygous for one gene C. Heterozygous for two genes D. Homozygous for two genes E. None of the above are correct Difficulty Level: Moderate Hoefnagels - Chapter 10 #31 Question Type: Comprehension 21 66. Mendel's monohybrid cross of "Tt" parents resulted in a tall to short ratio of: A. B. C. D. E. 1:1 1:2 2:1 3:1 1:3 Difficulty Level: Moderate Hoefnagels - Chapter 10 #33 Question Type: Knowledge 67. A dihybrid cross is a mating between two individuals that are each ______________ for ___________ gene (genes). A. Homozygous, one B. Homozygous, two C. Homologous, two D. Heterozygous, one E. Heterozygous, two Difficulty Level: Moderate Hoefnagels - Chapter 10 #38 Question Type: Comprehension 68. In the ABO blood type system the IA and IB alleles: A. B. C. D. E. Are recessive Are codominant Only one is expressed when both are present All the above are correct None of the above are correct Difficulty Level: Moderate Hoefnagels - Chapter 10 #41 Question Type: Comprehension 22 69. If the heterozygous phenotype is intermediate between those of the two different homozygotes, this is called: A. Codominanc e B. Incomplete dominance C. Independent assortment D. Epistasi s E. Polygeni c Difficulty Level: Moderate Hoefnagels - Chapter 10 #42 Question Type: Knowledge 70. Traits that depend on more than one gene are: A. Pleiotropi c B. Polygeni c C. Codominan t D. Recessiv e E. Incomplete dominant traits Difficulty Level: Moderate Hoefnagels - Chapter 10 #44 Question Type: Knowledge 71. In a karyotype, the major characteristic (characteristics) that uniquely identify each chromosome is (are): A. Banding pattern B. Size C. Centromere position D. All of the above are correct E. None of the above are correct Difficulty Level: Low Hoefnagels - Chapter 11 #7 Question Type: Comprehension 23 72. Linked genes, by definition, are genes that: A. Have no alleles B. Are found in the same species C. Are found on the same chromosome D. Have more alleles than usual E. Are alleles that are found in different daughter cells Difficulty Level: Moderate Hoefnagels - Chapter 11 #11 Question Type: Knowledge 73. If any of the traits that Mendel worked with had been due to linked genes, his dihybrid crosses: A. Would have had different results B. Would have produced more offspring C. Would have produced less offspring D. Would have exhibited a typical phenotypic ratio of 9:3:3:1 E. Would have produced sterile offspring Difficulty Level: Moderate Hoefnagels - Chapter 11 #12 Question Type: Comprehension 74. A dihybrid cross of linked genes theoretically gives a phenotypic ratio: A. B. C. D. E. Of 9:3:3:1 Of 2:1 That is the same as that for genes that are not linked Of 3:1 None of the above are correct Difficulty Level: Moderate Hoefnagels - Chapter 11 #13 Question Type: Comprehension 24 75. Crossing over is more likely to separate genes on a chromosome if they are: A. Close together B. Recessive genes C. Far apart D. Dominant genes E. Mutated genes Difficulty Level: Moderate Hoefnagels - Chapter 11 #15 Question Type: Comprehension 76. To inherit an autosomal dominant disorder a person could receive the disease causing allele from: A. The father only, not the mother B. The mother only, not the father C. The parent who does not exhibit the disease D. The mother or the father E. None of the above are correct Difficulty Level: Low Hoefnagels - Chapter 11 #18 Question Type: Comprehension 77. To inherit an autosomal recessive disorder requires a person to receive the disease causing allele from: A. The father only B. The mother only C. Only the parent having the disease D. Only one parent who is homozygous recessive for the disease E. Both parents Difficulty Level: Moderate Hoefnagels - Chapter 11 #19 Question Type: Comprehension 25 78. Diagrams depicting family relationships and phenotypes for a genetic disorder are: A. Linkage maps B. Pedigree charts C. Karyotype s D. Punnett squares E. Bell-shaped curves Difficulty Level: Low Hoefnagels - Chapter 11 #30 Question Type: Knowledge 79. The chromosome that plays the largest role in human sex determination is: A. The "X" chromosome B. Chromosome number 21 C. The "Y" chromosome D. The group of autosomes known as the SRY group E. None of the above are correct Difficulty Level: Low Hoefnagels - Chapter 11 #36 Question Type: Knowledge 80. A male expresses: A. Only the dominant alleles on his "X" chromosome B. Only the homozygous recessive alleles on his "X" chromosome C. Both the dominant and recessive alleles on his "X" chromosome D. None of the alleles on his "X" chromosome E. None of the above are correct Difficulty Level: Moderate Hoefnagels - Chapter 11 #38 Question Type: Comprehension 26 81. In a molecule of DNA: A. B. C. D. E. Adenine pairs with thymine Cytosine pairs with adenine Thymine pairs with uracil Adenine pairs with uracil All the above are correct Difficulty Level: Low Hoefnagels - Chapter 12 #5 Question Type: Knowledge 82. The "Central Dogma" refers: A. To the flow of genetic information in cells B. Genetic information passing from DNA to RNA by transcription C. Genetic information passing from RNA to protein by translation D. All of the above are correct E. None of the above are correct Difficulty Level: Low Hoefnagels - Chapter 12 #6 Question Type: Comprehension 83. DNA differs from RNA in that: A. DNA contains uracil B. DNA can catalyze chemical reactions C. DNA contains thymine D. DNA is usually single stranded E. DNA contains ribose Difficulty Level: Moderate Hoefnagels - Chapter 12 #9 Question Type: Knowledge 27 84. The type of RNA that carries the information that specifies a protein is: A. Messenger RNA B. Transfer RNA C. Ribosomal RNA D. All of the above are correct E. None of the above are correct Difficulty Level: Moderate Hoefnagels - Chapter 12 #10 Question Type: Knowledge 85. The type of RNA that helps align the ribosome and mRNA and catalyzes the reaction that creates the peptide bond is: A. B. C. D. E. Messenger RNA Transfer RNA Ribosomal RNA A codon None of the above are correct Difficulty Level: Moderate Hoefnagels - Chapter 12 #11 Question Type: Knowledge 86. The type of RNA that carries each amino acid to the ribosome is: A. Messenger RNA B. Transfer RNA C. Ribosomal RNA D. All of the above are correct E. None of the above are correct Difficulty Level: Moderate Hoefnagels - Chapter 12 #12 Question Type: Knowledge 28 87. A DNA sequence that signals a gene's start is: A. A codon B. An anticodon C. A terminator D. An amino acid attachment site E. A promoter Difficulty Level: Moderate Hoefnagels - Chapter 12 #15 Question Type: Knowledge 88. The process used by cells to convert the mRNA "message" into a sequence of amino acids is: A. Transcriptio n B. Translatio n C. Replicatio n D. Mitosis E. Amino acid synthesis Difficulty Level: Moderate Hoefnagels - Chapter 12 #17 Question Type: Knowledge 89. A three base sequence (loop) in tRNA that is complementary to a sequence of three bases in mRNA is: A. An anticodon B. A codon C. A promoter D. A terminator E. An amino acid attachment site Difficulty Level: Moderate Hoefnagels - Chapter 12 #19 Question Type: Knowledge 29 90. A tRNA molecule is "bilingual" because it binds to: A. Amino acids and DNA B. DNA and mRNA codons C. Codons of mRNA and amino acids D. Promoters and amino acids E. Promoters and terminators Difficulty Level: Moderate Hoefnagels - Chapter 12 #20 Question Type: Comprehension 91. The step of translation in which an mRNA, a small ribosomal subunit and the initiator tRNA are aligned together is: A. Mitosis B. Initiation C. Elongatio n D. Terminatio n E. Transcriptio n Difficulty Level: Moderate Hoefnagels - Chapter 12 #21 Question Type: Comprehension 92. The step of translation in which amino acids are added one at a time to the growing polypeptide is: A. Mitosis B. Initiation C. Elongatio n D. Terminatio n E. Transcriptio n Difficulty Level: Moderate Hoefnagels - Chapter 12 #22 Question Type: Comprehension 30 93. The step of translation in which release factors bind to a stop codon is: A. Mitosis B. Initiation C. Elongatio n D. Terminatio n E. Transcriptio n Difficulty Level: Moderate Hoefnagels - Chapter 12 #23 Question Type: Comprehension 94. A group of genes and other segments of DNA in Bacteria that are controlled together is: A. B. C. D. E. A proteome A chromosome A ribosome An operon A replication fork Difficulty Level: Moderate Hoefnagels - Chapter 12 #28 Question Type: Knowledge 95. In the Lac operon, the protein that binds to the operator to prevent transcription is: A. RNA polymerase B. DNA polymerase C. The repressor D. The promoter E. Lactos e Difficulty Level: Moderate Hoefnagels - Chapter 12 #30 Question Type: Comprehension 31 96. Proteins that initiate transcription in eukaryotes by recognizing sequences within the promoter region of a gene and attracting RNA polymerase are: A. Represso rs B. Transcription factors C. Inducer s D. TATA boxes E. Poly A Tails Difficulty Level: Moderate Hoefnagels - Chapter 12 #33 Question Type: Knowledge 97. A change in a cell's DNA sequence is: A. Replicatio n B. Transcriptio n C. Translatio n D. An operon E. A mutation Difficulty Level: Low Hoefnagels - Chapter 12 #34 Question Type: Knowledge 98. In a "missense" (nonsynonymous) mutation in an exon: A. B. C. D. E. The codon that mutates does not cause a change in the amino acid specified The codon that mutates causes a change in the amino acid specified The codon that mutates causes a stop codon to occur instead of the placement of an amino acid All of the above are correct answers None of the above are correct Difficulty Level: Moderate Hoefnagels - Chapter 12 #36 Question Type: Application 32 99. In a "silent" (synonymous) mutation that occurs in an exon: A. B. C. D. E. The codon that mutates does not cause a change in the amino acid specified The codon that mutates causes a change in the amino acid specified The codon that mutates causes a stop codon to occur instead of the placement of an amino acid All of the above are correct None of the above are correct Difficulty Level: Moderate Hoefnagels - Chapter 12 #37 Question Type: Application 100. A "frameshift" mutation: A. B. C. D. E. May be caused by an addition of any number of nucleotides (bases) not in multiples of three May be caused by a deletion of any number of nucleotides (bases) not in multiples of three Disrupts the reading frame of a gene Usually destroys a protein's ability to function All of the above are correct Difficulty Level: Low Hoefnagels - Chapter 12 #38 Question Type: Comprehension 33 Organismal Biology Section Two Exam Summary Category # of Questio ns Difficulty Level: Low 40 Difficulty Level: Moderate 60 Hoefnagels - Chapter 07 15 Hoefnagels - Chapter 08 22 Hoefnagels - Chapter 09 19 Hoefnagels - Chapter 10 14 Hoefnagels - Chapter 11 10 Hoefnagels - Chapter 12 20 Question Type: Applicatio n 6 Question Type: Compreh ension 41 Question Type: Knowledg e 53 1