ShanghaiTech Bioforum 2015 Advances in Integrative Biology of Cellular Processes Grand Kempinski Hotel Shanghai Nov. 9, 2015 MONDAY 18:00 – 20:00 20:00 – 22:00 Opening Reception Speakers’ Dinner with SIAIS Board Nov. 10, 2015 Tuesday 8:45– 9:00 Ian Wilson 9:00 – 9:40 Charles Weissmann 9:40 – 10:20 Tamas Barfai 10:20 – 10:50 10:50 – 11:30 11:30 – 12:10 Ben Shen Chi-Huey Wong 12:10 – 13:40 13:40 – 14:20 Yifan Cheng 14:20 – 15:00 Andrew Ward 15:00 – 15:30 15:30 – 16:10 Bo Huang 16:10 – 16:50 Carolyn Larabell 16:50 – 19:00 18:30 – 22:00 OPENING-WELCOME Nov. 10, 2015 TUESDAY Chair: Richard Lerner The winding path from phage to prion Major Kgaps between medical need and the response of the Pharmaceutical Industry BREAK Genome mining of enediyne natural products as antibody-drug conjugate payload candidates Chemistry and biology of glycosylation: carbohydrate-based cancer vaccine LUNCH Chair: Ian Wilson Single particle cryo-EM of integral membrane proteins – from blobology to atomic structures Cryo-EM of viral pathogens and implications for vaccine design BREAK Imaging the genome in living cells CAT scans of living cells POSTERS River Cruise and Dinner (speakers and invited guests) 9:00 – 9:40 David Baker 9:40 – 10:20 Andrej Sali Nov. 11, 2015 WEDNESDAY Chair: Design of protein structures, functions and assemblies Integrative modeling of biomolecular structures and networks Keynote Lecture 10:20– 10:50 10:50 – 11:30 11:30 – 12:10 12:15 – 13:45 13:45–14:25 14:25– 15:05 15:05 – 15:35 15:35 – 16:15 16:15 – 16:55 17:00 – 19:00 19:00 –21:00 9:00 – 9:40 9:40 – 10:20 10:20 –10:50 `0:5010:20bb7 10:50 – 11:30 77777ssss44jhh 1111111010:50 1050:00 Terrence Rabbitts Alexander Gabibov QM/MM maturation in silico of an immunoglobulin repertoire to generate improved targeted reactivity LUNCH Pand POSTE Chair: Haifan Lin RS and and Ernesto Carafoli The regulation of the calcium signal by membrane BBRC Lecture Poaters transporters: Focus on the plasma membrane calcium ATPase IP3 receptor as a signaling hub in health and disease Katsuhiko Mikoshiba BREAK Andrew Marks A structural biology approach towards understanding complex disorders of heart, muscle, brain and metabolism Hongyan Wang MeCP2 displays allelic expression imbalance and mutated MeCP2 affects both NSCs differentiation and heart development through the Notch pathway POSTERS BANQUET Nov. 12, 2015 THURSDAY Chair: Amgen Award Intro: Mingqiang Zhang Mass spectrometry of membrane proteins - the Carol Robinson lipid connection Mark Sansom Beili Wu 11:30 –12:10 Igor Stagljar 12:10- 12:20 Ian Wilson 12:20 – 13:30 BREAK Intracellular Immunotheraoy Amgen Lecture Multiscale simulations of biological membrane systems BREAK Structural studies of human purinergic receptors P2Y1R and P2Y12R Membrane protein interactomes in health & disease: application to lung cancer Conclusions and Farewell LUNCH (Workshop participants please pick up boxed lunch before the session starts) SATELLITE BBRC AUTHOR WORKSHOP (Free Access) Thursday (November 12, 2015) (Please pick up boxed lunch before the session starts) Chairs: Guang Yang and Ernesto Carafoli 12:45 – 13:15 Dolors Alsina Ethics & the peer-review process: a publisher’s perspective 13:15 – 13:45 Ernesto Carafoli Frauds, errors, sloppy research: the dark side of science 13:45 – 14:15 Glenn Begley Recognizing sloppy science (or 10% of the time it works every time) 14:15 – 15:00 Ian Wilson 15:00 – 16:00 Manuscript writing, submission, and publication: an editor’s perspective Moderator: Guang Yang General Discussion