02-2014
CURRICULUM VITAE
Name:
Birth Date:
Citizenship:
James Edward Klaunig, Ph.D. ATS, IATP
May 27, 1951
USA
Office Address:
Department of Environmental Health
School of Public Health
Indiana University
1025 East 7th st
Bloomington, IN 47405
Telephone 812 856-2448 (office)
812 856-2445 (office)
812 856-3957 (private)
Education:
1973
1976
1980
1980-1982
1990 -1991
B.S. in Biology, Ursinus College, Collegeville, Pennsylvania
M.A. in Biology, Montclair State University, Upper Montclair, New Jersey
Ph.D. in Experimental Pathology/Toxicology, University of Maryland School of Medicine,
Baltimore, Maryland (mentor, Benjamin F. Trump)
Postdoctoral Studies, Chemical Carcinogenesis, Department of Pathology, Medical College of
Ohio, Toledo, Ohio
Postdoctoral Studies (sabbatical leave), Chemical Carcinogenesis, Chemical Industry Institute of
Toxicology, Research Triangle Park, North Carolina
Academic and Professional Appointments:
2012 – Present
2010 – Present
2006 – 2010
2005 – 2009
2005 – 2010
1991 - 2010
1991 - 2010
1991 – Present
1991 - 2003
1991 - 2003
1990 - 1991
1988 - 1991
1987 - 1991
1986 - 1991
1982 - 1994
1982 - 1986
Adjunct Professor, SPEA, Indiana University, Bloomington, Indiana
Professor Department of Environmental Health, Indiana University, Bloomington,
Indiana
Professor of Public Health, Indiana University School of Medicine, Indianapolis, Indiana
Associate Director, Indiana University Cancer Center, Indiana University School of Medicine,
Indianapolis, Indiana
Robert B. Forney, Professor and Director of Toxicology, Indiana University School of Medicine,
Indianapolis, Indiana
Professor, Department of Pharmacology and Toxicology, Indiana University School of Medicine,
Indianapolis, Indiana
Director, Division of Toxicology, Department of Pharmacology and Toxicology, Indiana
University School of Medicine, Indianapolis, Indiana
Member of Graduate Faculty, Indiana University, Indianapolis, Indiana
Director, Department of Toxicology, State of Indiana
State Toxicologist, State of Indiana
Visiting Scientist, Chemical Industry Institute of Toxicology, Research Triangle Park, North
Carolina
Associate Professor, School of Allied Health, Medical College of Ohio, Toledo, Ohio
Associate Professor, Department of Pharmacology and Therapeutics, Medical College of Ohio,
Toledo, Ohio
Associate Professor, Department of Pathology, Medical College of Ohio, Toledo, Ohio
Member, Graduate Faculty, Medical College of Ohio, Toledo, Ohio
Assistant Professor, Department of Pathology, Medical College of Ohio, Toledo, Ohio
Board Certifications
Fellow, Academy of Toxicological Sciences
Fellow, International Academy of Toxicological Pathology
Hazardous Materials Manager
Honors & Awards:
2014
2012
2009
2008
2008
2006
2003
2002
2002
2001
1998
1997
1996
1973
1973
Highly Cited Researchers (2002-2012) Thomson Reuters, ISIhighlycited.com (out of 133 from the
discipline of Pharmacology and Toxicology)
Chairman’s Award, Indiana Criminal Justice Institute, State of Indiana,
George H. Scott Award, Toxicology Forum, Aspen, Colorado
Benjamin F. Trump Memorial Lectureship, Aspen Cancer Conference, Aspen, Colorado
Freehold Alumni Hall of Fame, Freehold High School, Freehold, New Jersey
John Doull Toxicology Lecture, University of Kansas, Medical School, Kansas City, Kansas
Sagamore of the Wabash (The highest award presented to a citizen of Indiana by the Governor of Indiana
for Service to the State)
Who’s Who 2000 Outstanding Scientists of the 21st Century
Kenneth P. Dubois Award, Midwest Society of Toxicology Chapter
IU Trustees Teaching Excellence Award
Who’s Who American Men and Women in Science
Guest Professor, Beijing University, Beijing, P.R. China
Otis R. Bowen, M.D. Distinguished Leadership Award, Indiana University School of Medicine,
Indianapolis, Indiana
Varsity Club Senior Award, Ursinus College, Collegeville, Pennsylvania
Team Captain and Most Valuable Player Award, Ursinus College, Collegeville, Pennsylvania
Additional Training:
1991
Indiana University Center for Studies of Law in Action (Tests for BAC in Highway Safety
Programs: Supervision and Expert Testimony)
Society Memberships
American Association of Cancer Research
American College of Toxicology
Indianapolis Press Club
International Association of Forensic Toxicologists
International Society for Free Radical Research
Society for Clinical and Translational Science
Society of Toxicologic Pathologists
Society of Toxicology
Sigma Xi
COMMITTEES AND ADMINISTRATIVE SERVICE:
Extramural Service
State of Indiana
2011 – 2012
Member, Toxicology Advisory Board, State of Indiana (Governor Appointment /legislative
mandate)
1996—Present Member, Governor’s Council on Impaired and Dangerous Driving; State of Indiana (Governor
Appointment)
1991—2003
Member, State of Indiana Controlled Substances Advisory Committee (Governor Appointment)
2
1991—2003
1991 - 2003
1991 - 2003
Member, State of Indiana Pesticide Review Board (Governor Appointment)
State Toxicologist, State of Indiana
Director, Department of Toxicology, State of Indiana
United States Environmental Protection Agency
2012 – 2015
Member, EPA Science Advisory Board (SAB) Chemical Assessment Advisory Committee
2008-2009
Chair, U.S. Environmental Protection Agency, BOSC Subcommittee, Human Health Study
Research Program
2007
Chair, U.S. Environmental Protection Agency Environmental Carcinogenesis Division Mid-Cycle
Review
2005 - 2008
Chair, U.S. Environmental Protection Agency Human Health Research Program Review
2002 - 2008
Member, Science Advisory Board Exposure and Human Health Committee
2005
Member, U.S. Environmental Protection Agency Science Advisory Board, Perfluorooctanoic Acid
(PFOA) Risk Assessment Review Panel
2004
Chair, Peer Review, NHEERL’s Environmental Carcinogenesis Division (ECD)
2003
Chair, Human Health Research Strategy Review Panel, EPA Science Advisory Board
2000
Member, Scientific Advisory Panel subcommittee on Atrazine Health Risk Assessment
1999
Peer Reviewer, IRIS document on Chlorite
1999
Member, Scientific Advisory Panel subcommittee on Chloroform Carcinogenicity
1999
Peer Reviewer, IRIS document on Bromate
1998
Peer Reviewer, IRIS document on 1, 3 dichloropropanol
1994 - 2005
Member, USEPA Committee for Cancer Risk Assessment Guidelines, Washington, D.C.
Society of Toxicology
Elected positions
2003—2005
2002—2003
1998—1999
1997—1998
1996—1998
1996—1997
1995—1998
1995—1996
1992—1994
Treasurer, Society of Toxicology
Treasurer Elect, Society of Toxicology
President, Carcinogenesis Specialty Section, Society of Toxicology
Chairman, Education Committee, Society of Toxicology
President, Ohio Valley Society of Toxicology
Vice President, Carcinogenesis Specialty Section, Society of Toxicology
Member, Education Committee, Society of Toxicology
Vice President, Ohio Valley Society of Toxicology
Councilor, Mechanisms Specialty Section, Society of Toxicology
Appointed positions
2012 – 2015
Member, Society of Toxicology Audit Committee
2007 - 2009
Member, Society of Toxicology Endowment Committee
1998—2001
Member, Finance Committee, Society of Toxicology
1998—1999
Project Coordinator, Fourth Edition, Resource Guide to Careers in Toxicology
1997—1998
Member, (Ad Hoc) Toxicology Education Foundation
1993—1995
Member, Program Committee, Seventh International Congress of Toxicology
1994
Judge, Mechanisms Specialty Section 33rd Annual Meeting, Society of Toxicology
1993
Judge, Mechanisms Specialty Section 32nd Annual Meeting, Society of Toxicology
1992
Judge, Mechanisms Specialty Section 31st Annual Meeting, Society of Toxicology
1988—1992
Member, Program Committee, Society of Toxicology
Society of Toxicologic Pathology
2012
Scientific Program Committee, Society of Toxicologic Pathology
2012
Co-Chair, Chemical-Based Tissue Reactivity, Society of Toxicologic Pathology Annual
Meeting
2009
Co-Chair, Mechanisms of Carcinogenicity, Society of Toxicologic Pathology Annual Meeting
3
International Life Sciences Institute
2014 - 2017
Editor-in-Chief – Health and Environmental Science Institute (HESI)
2010 – 2013
Scientific Advisor, Emerging Issues Steering Committee (EISC), Health & Environmental Science
Institute
2010
Science Advisor, Epidemiology Subcommittee, Health and Environmental Sciences Institute
2010
Member, RISK21 committee, Health and Environmental Sciences Institute, Washington, DC
2005 - 2007
Executive Committee, Health and Environmental Science Institute
2001 - 2008
Member, Board of Trustees, Health and Environmental Science Institute
2005 - Present Co Chair, Angiosarcoma Mechanism of Action Subgroup, PPAR Committee, HESI
2004 - 2006
Chair, Communications Committee, Health and Environmental Science Institute
2002 - 2004
Vice Chair, Communications Committee, Health and Environmental Science Institute
2002 - 2003
Chair, Peroxisome Proliferator (PPAR alpha) Working Group, Human Relevance of Rodent
Tumors, RSI
Other
2014 - 2016
2011
2011 - 2013
2010 - 2013
2007
2005 – present
2005 - present
2002 - 2004
2000 - 2004
2000
2000 - 2002
2000
1999 - 2003
1999
1998 – 2000
1998
1991 - 1993
1991 – 1996
1989
President, Toxicology Forum Board of Directors, Washington, D.C.
Member, National Toxicology Program, Bioassay Review Committee, NIEHS, RTP, NC.
Member, Committee on the Analysis of Cancer Risks in Populations Near Nuclear Facilities,
National Academy of Sciences, Washington, DC
Steering committee, Receptors in Carcinogenesis, Mode of Action and Dose response, TERA,
RTP, NC
Co-Chair, Acrylonitrile’s Modes of Carcinogenic Action (MOA) in the Rat and Mouse and Their
Relevance to Human Risk Assessment, Acrylonitrile (AN) Group, Arlington, Virginia
Member, the Toxicology Forum Board of Directors
Member, Toxicology Forum Program committee
Member, Outreach Committee, American College of Toxicology
Member, National Toxicology Program Board of Scientific Counselors, NIH/NIEHS, RTP, NC
Member, Carcinogenesis Review Panel, Thyroid Carcinogenesis, WHO, International Agency for
Research in Cancer, Lyon, France
Member, SOT/NIEHS/USEPA, Working Group on Science Based Decisions Concerning
Toxicology of Mixtures, Washington, D.C
Member, Graduate Program Review, School of Public Health, University of North Carolina
Faculty, American Chemical Society, Principles of Toxicology (Chemical Carcinogenesis),
Annual Award Society, Washington, D.C
Member, American Association for Cancer Research State Legislative Committee
Member, Human Effects Advisory Panel, The Joint Non-lethal Warfare Directorate, DOD
Chair, Graduate Program Review Committee, Texas A & M University
Member, Education Committee, American College of Toxicology
Chairman, Scientific Advisory Panel on Dieldrin Carcinogenesis, Dermigen Inc.
Member, Program Review Committee, National Institute of Occupational Safety and Health
Grant Reviews / Study Sections
2013
2009 – present
2008—2012
2008
2007
2005—2008
Chair, Grant Review Panel, National Cancer Institute, June
Full member and Reviewer, Italian Ministry for Education, University and Research,
Full Member, National Cancer Institute, Cancer Etiology Study Section, Center for Scientific
Review
Ad hoc Member, National Cancer Institute, Cancer Etiology Study Section, NIH/NCI
Member, National Cancer Institute, Designated Cancer Center Site Visit
Co-Chair, PPAR Hemangiosarcomas Working Group, HESI/ILSI
4
2006
2006
2006
2006
2006
2005
2004
2002
1998
1996
1994
1993—1994
1993
1992
1992
1992
1991
1991
Member, Site Visit Pawl Laboratory of Metabolism, National Cancer Institute, Center for Cancer
Research, October
Member, Grant Review Committee, Czech Science Foundation, September
Member, Grant Review Committee, Canadian Liver Foundation, September
Chairman, National Cancer Institute Special Emphasis Panel, ZCA1 GRB-S (C1), Antibody Array
Cancer Detection – Phase II, August
Chairman, National Cancer Institute Special Emphasis Review Panel, ZCA1 SRRB-U (C1)
Chairman, National Cancer Institute Special Emphasis Review Panel, Cancer Sample Preparation /
Cancer Detection
Chairman, National Cancer Institute Special Emphasis Review Panel, Innovative Toxicology
Models for Drug Evaluation
Chairman, National Cancer Institute Special Emphasis Panel, Innovative Toxicology
Member, Grant Review Committee, Italian Minister for Universities and Research
Member, Biological and Biomedical Review Committee, State of Texas
Member, Ad Hoc Study Section, Alternative Models for Toxicological Studies, (NCI / NIEHS)
Ad Hoc Member, Metabolic Pathology Study Section, NIH
Chairman, Ad Hoc Study Section, Small Grants for Nonmammalian Models, NIH
Member, Ad Hoc Study Section, Viral Oncogenesis and Pathogenesis of Hepatic Cancer, NIH
Member, Ad Hoc Study Section on Aquatic Toxicology, NIH
Chairman, Biological Models and Materials Research Program, National Center for Research
Resources, Department of Health and Human Services
Member, Ad Hoc Study Section on Role of Cell Proliferation in Liver Carcinogenesis, NIH
Member, Ad Hoc Study Section on Aquatic Toxicology, NIH
Institutional Service:
2013 – 2014
Chair, Faculty Search and Screen Committee, School of Public Health, Department of
Environmental Health, Bloomington, Indiana
2012 – 2014
Member, School of Public Health, Budgetary Affairs Committee, Bloomington, Indiana
2012 – present Member, School of Public Health, Promotion and Tenure Review Committee, Bloomington,
Indiana
2012 – present Networks, Complex Systems & Health PDT Committee, Indiana University, Bloomington,
Indiana
2012 – present Member, School of Public Health ,Research Space Committee, IU Bloomington
2012 – present Member, School of Public Health , Outstanding Early Career Scholar Award Committee, IU
Bloomington
2012 – present Member, School of Public Health, School Promotion to Full Professor Committee, IU
Bloomington,
2012 – present Alternate, School of Public Health Faculty Council, , IU Bloomington
2012 – present Member, Environmental Health Chair Search Committee, School of Public Health, IU
Bloomington
2012
Member, Epidemiology Search Committee, School of Health, Physical Education, and
Recreation, Indiana University, Bloomington, Indiana
2011
Member, Senior Associate Dean Search Committee, School of Health, Physical Education, and
Recreation, Indiana University, Bloomington, Indiana
2011
Chair, Epidemiology Search Committee, School of Health, Physical Education, and Recreation,
Indiana University, Bloomington, Indiana
2010 –present
Member, Lab Animal Resources (LAR) Fiscal Oversight Committee, IU Bloomington
2010- 2012
Member, SPH Epi-Biostat Cluster Faculty Recruitment, School of Public Health
2010 -2011
Chair, Department of Environmental Health , HPER , Indiana University Bloomington, IN
2010
The Advisory Committee (AC) to the Anthropological Center for Training and Research on
Global Environmental Change (ACT), Indiana University
5
2008 – Present
2008 – present
2008 – 2010
2008
2008
2008
2008
2007
2007
2007—2009
2007
2007
2006- 2011
2006—2007
2006—2007
2006—2007
2006—2010
2006
2006
2006
2006 – 2010
2005 – 2009
2005 – 2010
2004 – 2010
2001—2010
2000 – 2003
1999—2010
1998—2010
1996—1997
1994—2000
Member/ Executive Committee, Center for Environmental Sciences, Indiana University,
Bloomington, Indiana
Co Director, Environmental Genomics Consortium, Indiana University, Bloomington, Indiana
Program Leader, Molecular and Environmental Carcinogenesis, IU Simon Cancer Center, Indiana
University School of Medicine, Indianapolis, Indiana
Chair, Molecular Carcinogenesis Search and Screen Committee, Indiana University Cancer
Center, Indianapolis, IN
Member, Indiana University CTSI: Accelerating Clinical and Translational Research Grant
Review Committee
Member, Behavioral Science Search and Screen Committee, Department of Public Health, Indiana
University School of Medicine
Member, Algal Toxicology Search and Screen Committee, Department of Earth Sciences, Indiana
University
Member, Center for Earth and Environmental Science Search and Screen Committee, Indiana
University
Chair, Indiana State Toxicology Department Director Search and Screen Committee, Indiana
University School of Medicine
Chair, Center for Environmental Health Search and Screen Committee, Indiana University School
of Medicine
Chair, Neurotoxicological Sciences Search and Screen Committee, Indiana University School of
Medicine
Member, Committee to identify public health concerns with confined/concentrated animal feeding
Operations (CAFOs), Purdue University, Department of Animal Sciences
Director, Oxidative Stress Core CTSI, Indiana University, Bloomington, Indiana
Member, Social Assets and Vulnerabilities Indicators (SAVI) Research Advisory Committee, The
Polis Center, Indiana University
Member, Breast Cancer Faculty Search Committee, Indiana University Cancer Center
Associate Director, Indiana University Cancer Center, Bloomington Campus
Member, Laboratory Animal Resource Center (LARC) Advisory Committee, Indiana University
School of Medicine
Organizer and Co-Leader of Indiana University and Purdue University Retreat on Cancer
Prevention and Control, September
Reviewer for the IUPUI Research Support Fund Grant (RSFG) Mechanism, Indiana University
IU School of Medicine Laboratory Animal Resource Center Advisory Committee
Director, Center for Environmental Health, Indiana University School of Medicine, Indianapolis,
Indiana
Associate Director, Indiana University Cancer Center, Indiana University School of Medicine,
Indianapolis, Indiana
Adjunct Professor of Emergency Medicine, Indiana University School of Medicine, Indianapolis,
Indiana
Member, Center for Earth and Environmental Science, Indiana University ~ Purdue University,
Indianapolis, Indiana
Member, Biohazard Committee, Indiana University, Indianapolis, Indiana
Faculty Member, Graduate Program in Medical Neurobiology, Indiana University School of
Medicine, Indianapolis, Indiana
Member, Environmental Health Concentration Curriculum Review Committee, Master of Public
Health Program, Indiana University
Member, Master of Public Health Concentration Coordinating Committee, Indiana University
Member, Advisory Board Center for Earth and Environmental Science, IUPUI
Member, Pharmacology and Toxicology Executive Committee, Indiana University School of
Medicine, Indianapolis, Indiana
6
1993—1994
1993—1999
1992—Present
1992—1997
1992—1993
1992—1993
1989—1991
1989—1991
1989 - 1991
1988 - 1991
1987 - 1991
1987—1991
1986—1988
1985—1991
1985—1991
1984—1985
1983—1984
1981
1980 - 1982
1980—1991
Chairman, Raymond Paradise Symposium Committee, Department of Pharmacology and
Toxicology, Indiana University School of Medicine, Indianapolis, Indiana
Member, Pharmacology and Toxicology Development Committee, Indiana University School of
Medicine, Indianapolis, Indiana
Alternate Member, Institutional Review Board, Indiana University School of Medicine,
Indianapolis, Indiana
Member, Laboratory Animal Facility Advisory Board, Indiana University School of Medicine,
Indianapolis, Indiana
Member, Raymond Paradise Symposium Committee, Department of Pharmacology and
Toxicology, Indiana University School of Medicine, Indianapolis, Indiana
Member, Search and Screen Committee for Chairman of Geology, Indiana University,
Indianapolis, Indiana
Member, LCME Subcommittee on Research, Medical College of Ohio
Member, Flow Cytometer Research Committee, Medical College of Ohio, Toledo, Ohio
Adjunct Associate Professor of Toxicology, University of Toledo, College of Pharmacy, Toledo,
Ohio
Associate Professor, School of Allied Health, Medical College of Ohio, Toledo, Ohio
Adjunct Professor, Center for Photochemical Green State University, Bowling
Green, Ohio
Course Coordinator, Pathology Course for Physical Therapy Students, Medical College of Ohio,
Toledo, Ohio
Member, Search Committee for Physiology Chairman, Medical College of Ohio, Toledo, Ohio
Department of Pathology Research Committee, Medical College of Ohio, Toledo, Ohio
Medical School Admissions Interviewer, Medical College of Ohio, Toledo, Ohio
Secretary, Faculty Senate, Medical College of Ohio, Toledo, Ohio
Faculty Senate Representative, Medical College of Ohio, Toledo Ohio
Adjunct Faculty Member, W. Alton Jones Cell Science Center, Lake Placid, New York
Instructor, Department of Pathology, Medical College of Ohio, Toledo, Ohio
Library Committee, Medical College of Ohio, Toledo, Ohio
Editorial Boards:
2014 - 2016
2008—present
2005—2008
2005—Present
1997—2004
1998—2003
1998—2002
1992—1999
1997—1999
1992—1997
1991—1997
1990—1997
Editor-in-Chief, HESI Publications
Editorial Board, Toxicology
Editor- in-Chief, Toxicologic Pathology
Associate Editor, The Scientific World (TSW) Toxicology
Associate Editor, Toxicological Sciences
Editorial Board, Toxicologic Pathology
Editorial Board, Cell Biology and Toxicology
Editorial Board, Journal of Toxicology and Environmental Health
Editorial Board, International Journal of Toxicology
Associate Editor, IN VITRO, Cellular and Developmental Biology
Carcinogenesis Section Editor, Journal of the American College of Toxicology
Associate Editor, Journal of the American College of Toxicology
7
BIBLIOGRAPHY
Summary
Google Scholar 51 manuscripts with 40 or better citations
Web of Science citations
Manuscripts noted
237
Times cited
6446
Average citations per manuscript
27.20
h-index
42
Highly Cited Researchers in 2014 for 2002-2012; (highlycited.com) (one of 133 in pharmacology and
toxicology)
MANUSCRIPTS:
1.
Klaunig, J.E., Koepp, S., McCormick, J. (1975). Acute Toxicity of a Native Mummichog Population
(Fundulus heteroclitus) to Mercury. Bulletin of Environmental Contamination and Toxicology, 14(5), 534536.
2.
Doyle, M., Koepp, S., Klaunig, J.E. (1976). Acute Toxicological Response of the Crayfish (Orconectes
limosus) to Mercury. Bulletin of Environmental Contamination and Toxicology, 16, 422-424.
3.
Lipsky, M.M., Klaunig, J.E., Hinton, D.E. (1978). Comparison of the Acute Response to Polychlorinated
Biphenyl in Liver of Rat and Channel Catfish: A Biochemical and Morphologic Study. Journal of
Toxicology and Environmental Health, 4(1), 107-121.
4.
Hinton, D.E., Klaunig, J.E., Lipsky, M.M. (1978). PCB-Induced Alterations in Teleost Liver: A Model for
Environmental Disease in Fish. Marine Fisheries Review, 49, 47-50.
5.
Klaunig, J.E., Lipsky, M.M., Trump, B.F., Hinton, D.E. (1979). Biochemical and Ultrastructural Changes in
Teleost Liver Following Subacute Exposure to PCB. Journal of Environmental Pathology and Toxicology,
2(4), 953-963.
6.
Lipsky, M.M., Hinton, D.E., Goldblatt, P.J., Klaunig, J.E., Trump, B.F. (1979). Iron Negative Foci and
Nodules in Safrole-Exposed Mouse Liver Made Siderotic by Iron-Dextran Injection. Pathology Research and
Practice, 164(2), 178-185.
7.
Lipsky, M.M., Hinton, D.E., Klaunig, J.E., Goldblatt, P.J., Trump, B.F. (1980). Gamma Glutamyl
Transpeptidase in Safrole-Induced, Presumptive Premalignant Mouse Hepatocytes. Carcinogenesis, 1, 151156.
8.
Hinton, D.E., Klaunig, J.E., Jack, R.M., Lipsky, M.M., Trump, B.F. (1981). Evaluation of the Channel
Catfish Ictalurus punctatus (Rafinesque) as a Test Species in Chemical Carcinogenesis Studies. In Vitro,
Journal of the American Society of Testing and Materials, 737, 226-238.
9.
Lipsky, M.M., Hinton, D.E., Klaunig, J.E., Trump, B.F. (1981). Biology of Hepatocellular Neoplasia in the
Mouse. I. Histogenesis of Safrole-Induced Hepatocellular Carcinoma. Journal of the National Cancer
Institute, 67(2), 365-376.
10.
Lipsky, M.M., Hinton, D.E., Klaunig, J.E., Goldblatt, P.J., Trump, B.F. (1981). Biology of Hepatocellular
Neoplasia in the Mouse. II. Sequential Enzyme Histochemical Analysis of BALB/c Mouse Liver during
Safrole-Induced Carcinogenesis. Journal of National Cancer Institute, 67(2), 377-392.
8
11.
Lipsky, M.M., Hinton, D.E., Klaunig, J.E., Trump, B.F. (1981). Biology of Hepatocellular Neoplasia in the
Mouse. III. Electron Microscopy of Safrole-Induced Hepatocellular Adenomas and Hepatocellular
Carcinomas. Journal of National Cancer Institute, 67(2), 393-405.
12.
Klaunig, J.E., Goldblatt, P.J., Hinton, D.E. Lipsky, M.M., Chacko, J., Trump, B.F. (1981). Mouse Liver
Cell Culture. I. Hepatocyte Isolation. In Vitro, 17(10), 913-925.
13.
Klaunig, J.E., Goldblatt, P.J., Hinton, D.E., Lipsky, M.M., Chacko, J., Trump, B.F. (1981). Mouse Liver
Cell Culture. II. Primary Culture. In Vitro, 17(10), 926-934.
14.
Stoner, G.D., Babcock, M.S., Cothern, G.A., Klaunig, J.E., Gunning, W.T. III, Knipe, S.M. (1982).
Transformation of Rat Esophageal Epithelial Cells with N-nitrosobenzylmethylamine. In Vitro,
Carcinogenesis, 3(6), 629-634.
15.
Klaunig, J.E., Goldblatt, P.J., Hinton, D.E., Lipsky, M.M., Knipe, S.M., Trump, B.F. (1982). Morphologic
and Functional Studies of Mouse Hepatocytes in Primary Culture. Anatomical Record, 204(3), 231-243.
16.
Castonguay, A., Lin, D., Stoner, G.D., Radok, P., Furuya, K., Hecht, S.S., Schut, H.A., Klaunig, J.E. (1983).
Comparative Carcinogenicity in A/J Mice and Metabolism by Cultured Mouse Peripheral Lung of N’nitrosonornicotine, 4-(Methylnitrosamino) -1-(3-Pyridyl)-1-Butanone, and their Analogues. Cancer
Research, 4(3), 1223-1229.
17.
Selman, S.H., Goldblatt, P.J., Christoforidis, A.J., Klaunig, J.E., Collard, R.K., Jhunjhunwala, J.S., Kripp,
K.A. (1983). Osteoblastic Lesions in a Patient with a Bladder Filling Defect. Journal of Urology, 130(3),
522-525.
18.
Selman, S.H., Keck, R.W., Klaunig, J.E., Kreimer-Birnbaum, M., Goldblatt, P.J., Britton, S.L. (1983).
Acute Blood Flow Changes in Transplantable FANFT-Induced Urothelial Tumors Treated with
Hematoporphyrin Derivative and Light. Surgical Forum, 34, 676-678.
19.
Constantini, M.G., Klaunig, J.E., Goldblatt, P.J. (1984). Kinetics of DNA Repair Synthesis Induced by
Bleomycin and N-Methyl-N-Nitrosourea in Isolated Rat Liver Nuclei. Journal of Experimental Pathology,
1(2), 89-101.
20.
Klaunig, J.E., Barut, B.A., Goldblatt, P.J. (1984). Preliminary Studies on the Usefulness of Medaka,
Oryzias latipes, Embryos in Carcinogenicity Testing. National Cancer Institute Monographs, 65, 155-161.
21.
Klaunig, J.E. (1984). Establishment of Fish Hepatocyte Cultures for Use in In Vitro Carcinogenicity
Studies. National Cancer Institute Monographs, 65, 163-173.
22.
Stoner, G.D., Greisiger, E.A., Schut, H.A, Pereira, M.A., Loeb, T.R., Klaunig, J.E., Branstetter, D.G. (1984).
A Comparison of the Lung Adenoma Response in Strain A/J Mice after Intraperitoneal and Oral
Administration of Carcinogens. Toxicology and Applied Pharmacology, 72 (2), 313-323.
23.
Jones, R.T., Klaunig, J.E., Sanefuji, H., Hinton, D.E. (1984). A Method for the Organ Explant Culture of
Fish Kidney Tubules. Journal of Tissue Culture Methods, 7(4), 185-190.
24.
Kreimer-Birnhaum, M., Baumann, J.L., Klaunig, J.E., Keck, R., Goldblatt, P.J., Selman, S.H. (1984).
Chemical Studies with Hematoporphyrin Derivative in Bladder Cell Lines. Progress in Clinical & Biological
Research, 170, 335-350.
25.
Selman, S.H., Kreimer-Birnbaum, M., Klaunig, J.E., Goldblatt, P.J., Keck, R.W., Britton, S.L. (1984).
9
Blood flow in Transplantable Bladder Tumors Treated with Hematoporphyrin Derivative and Light. Cancer
Research, 44(5), 1924-1927.
26.
Klaunig, J.E., Goldblatt, P.J., Hinton, D.E., Lipsky, M.M., Trump, B.F. (1984). Carcinogen Induced
Unscheduled DNA Synthesis (UDS) in Mouse Hepatocytes. Toxicologic Pathology, 12(2), 119-125.
27.
Klaunig, J.E., Ruch, R.J., Goldblatt, P.J. (1985). Trout Hepatocyte Culture: Isolation and Primary Culture.
In Vitro, Cellular and Developmental Biology, 21(4), 221-228.
28.
Klaunig, J.E., Selman, S.H., Schafer, P.J., Shulok, J., Britton, S.L., Goldblatt, P.J. (1985).
Morphologic Studies of Bladder Tumors Treated with Hematoporphyrin Derivative Photochemotherapy.
American Journal of Pathology, 119(2), 236-243.
29.
Chang, L.W., Pereira, M.A., Klaunig, J.E. (1985). Cytotoxicity of Halogenated Alkanes in Primary Cultures
of Rat Hepatocytes from Normal, Partial Hepatectomized, and Preneoplastic/Neoplastic Liver. Toxicology
and Applied Pharmacology, 80(2), 274-283.
30.
Selman, S.H., Goldblatt, P.J., Klaunig, J.E., Keck, R.W., Kreimer-Birnbaum, M. (1985). Localization of
Hematoporphyrin Derivative in Injured Bladder Mucosa: An Experimental Study. Journal of Urology,
133(6), 1104-1107.
31.
Ruch, R.J., Klaunig, J.E., Pereira, M.A. (1985). Selective Resistance to Cytotoxic Agents in Hepatocytes
Isolated from Partial Hepatectomized and Neoplastic Mouse Liver. Cancer Letters, 26(3), 295-301.
32.
Goldblatt, P.J., Gunning, W.T., Klaunig, J.E. (1985). Light and Electron Microscopy of Peripheral Blood.
Micron and Microscopic Acta, 16(3), 195-198.
33.
Shulok, J.R., Klaunig, J.E., Selman, S.H., Schafer, P.J., Goldblatt, P.J. (1986). Cellular Effects of
Hematoporphyrin Derivative Photodynamic Therapy on Normal and Neoplastic Rat Bladder Cells.
American Journal of Pathology, 122(2), 277-283.
34.
Pereira, M.A., Klaunig, J.E., Herren-Freund, S.L., Ruch, R.J. (1986). Effect of Phenobarbital on the
Development of Liver Tumors in Juvenile and Adult Mice. Journal National Cancer Institute, 77(2), 449452.
35.
Barut, B.A., Klaunig, J.E. (1986). Isolation and Characterization of Metastatic Sublines from a Murine
Transitional Cell Bladder Carcinoma. Clinical and Experimental Metastasis, 4(1), 1-11.
36.
Burns, R.A., Klaunig, J.E., Shulok, J.R., Davis, W.J., Goldblatt, P.J. (1986). Tumor Localizing and
Photosensitizing Properties of Hematoporphyrin Derivative in Hamster Buccal Pouch Carcinoma. Oral
Surgery, Oral Medicine, Oral Pathology, 61(4), 368-372.
37.
Dixit, R., Schut, H.A., Klaunig, J.E., Stoner, G.D. (1986). Metabolism and DNA Binding of 2, 6
Dinitrotoluene in Fisher 344 Rats and A/J Mice. Toxicology and Applied Pharmacology, 82(1), 53-61.
38.
Klaunig, J.E., Ruch, R.J., Periera, M.A. (1986). Carcinogenicity of Chlorinated Methane and Ethane
Compounds Administered in Drinking Water to Mice. Environmental Health Perspectives, 69, 89-95.
39.
Ruch, R.J., Klaunig, J.E., Schultz, N.E., Askari, A., Lacher, D.A., Periera, M.A. (1986). Mechanisms of
Chloroform and Carbon Tetrachloride in Primary Cultured Mouse Hepatocytes. Environmental Health
Perspectives, 65, 301-305.
40.
Ruch, R.J., Klaunig, J.E. (1986). Antioxidant Prevention of Tumor Promoter Induced Inhibition of Mouse
Hepatocyte Intercellular Communication. Cancer Letters, 33(2), 137-150.
10
41.
Nigrovic, V., Klaunig, J.E., Smith, S.L., Schultz, N.E., Wajskol, A. (1986). Comparative Toxicity of
Atracurium and Metocurine in Isolated Rat Hepatocytes. Anesth. Analg. 65(11), 1107-1111.
42.
Ruch, R.J., Klaunig, J.E. (1986). Effects of Tumor Promoters, Genotoxic Carcinogens and
Hepatocytotoxins on Mouse Hepatocyte Intercellular Communication. Cell Biology and Toxicology, 2(4),
469-483.
43.
Ruch, R.J., Klaunig, J.E., Pereira, M.A. (1987). Inhibition of Intercellular Communication between Mouse
Hepatocytes by Tumor Promoters. Toxicology and Applied Pharmacology, 87(1), 111-120.
44.
Nigrovic, V., Klaunig, J.E., Smith, S.L., Schultz, N.E. (1987). Potentiation of Atracurium Toxicity in
Isolated Rat Hepatocytes by Inhibition of its Hydrolytic Degradation Pathway. Anesth. Analg., 66(6), 512516.
45.
Goldblatt, P.J., Hampton, J.A., Didio, L., Skeel, K., Klaunig, J.E. (1987). Morphologic and Histochemical
Analysis of the Newt (Notophthalmus viridescens) Liver. Anatomical Record, 217(4), 328-338.
46.
Hampton, J.A., Klaunig, J.E., Goldblatt, P.J. (1987). Resident Sinusoidal Macrophages in the Liver of the
Brown Bullhead (Ictalurus nebulosus): An Ultrastructural, Functional and Cytochemical Study. Anatomical
Record, 219(4), 338-346.
47.
Klaunig, J.E., Ruch, R.J. (1987). Strain and Species Effects on the Inhibition of Hepatocyte Intercellular
Communication by Liver Tumor Promoters. Cancer Letters, 36(2), 161-168.
48.
Klaunig, J.E., Weghorst, C.M., Pereira, M.A. (1987). Effect of the Age of B6C3F1 Mice on Phenobarbital
Promotion of Diethylnitrosamine-Initiated Liver Tumors. Toxicology and Applied Pharmacology, 90 (1),
79-85.
49.
Klaunig, J.E., Barut, B.A. (1987). The Efficacy of Chemotherapeutic Agents Against Murine Bladder
Metastasis. Journal of Urology, 138(6), 1471-1473.
50.
Klaunig, J.E., Ruch, R.J. (1987). Role of Cyclic AMP in the Inhibition of Mouse Hepatocyte Intercellular
Communication by Liver Tumor Promoters. Toxicology and Applied Pharmacology, 91(2), 159-170.
51.
Klaunig, J.E., Barut, B.A. (1988). Role of the Implantation Site on the Metastatic Ability of the Murine
MBT-2 Transitional Cell Carcinoma. Urological Research, 16(1), 19-21.
52.
Ruch, R.J., Klaunig, J.E. (1988). Kinetics of Phenobarbital Inhibition of Intercellular Communication in
Mouse Hepatocytes. Cancer Research, 48(9), 2519-2523.
53.
Ruch, R.J., Klaunig, J.E. (1988). Inhibition of Mouse Hepatocyte Intercellular Communication by ParaquatGenerated Oxygen Free Radicals. Toxicology and Applied Pharmacology, 94(3), 427-436.
54.
Klaunig, J.E., Barut, B.A. (1988). Influence of Transplantation Site on Metastatic Ability of Mouse Bladder
Carcinoma Sublines. Journal of Urology, 140(4), 844-847.
55.
Klaunig, J.E., Weghorst, C.M., Pereira, M.A. (1988). Effect of Phenobarbital on Diethylnitrosamine and
Diethylnitrosamine-Induced Hepatocellular Tumors in Male B6C3F1 Mice. Cancer Letters, 42(1-2), 133139.
56.
Klaunig, J.E., Pereira, M.A., Ruch, R., Weghorst, C.M. (1988). Dose-Response Relationship of
Diethylnitrosamine-Initiated Tumors in Neonatal Balb/c Mice: Effect of Phenobarbital Promotion.
Toxicologic Pathology, 16(3), 381-385.
11
57.
Klaunig, J.E., Ruch, R.J., DeAngelo, A.B., Kaylor, W.H. (1988). Inhibition of Mouse Hepatocyte
Intercellular Communication by Phthalate Monoesters. Cancer Letters, 43(1-2), 65-71.
58.
Nigrovic, V., Pandya, J.B., Klaunig, J.E., Fry, K. (1989). Reactivity and Toxicity of Atracurium and its
Metabolites in Vitro. Canadian Journal of Anesthesia, 36(3 Part 1), 262-268.
59.
Ruch, R.J., Cheng, S.J., Klaunig, J.E. (1989). Prevention of Cytotoxicity and Inhibition of Intercellular
Communication by Antioxidant Catechins Isolated from Chinese Green Tea. Carcinogenesis, 10(6), 10031008.
60.
Klaunig, J.E., Ruch, R.J., Lin, E.L. (1989). Effects of Trichloroethylene and its Metabolites on Rodent
Hepatocyte Intercellular Communication. Toxicology and Applied Pharmacology, 99(3), 454-465.
61.
Birkhahn, R.H., Awad, S., Klaunig, J.E., Thomford, N.R. (1989). Interaction of Ketosis and Liver
Regeneration in the Rat. Journal of Surgical Research, 47(5), 427-432.
62.
Gross, S., Bandyopadhayay, S., Klaunig, J.E., Somani, P. (1989). Amiodarone and
DesethylamiodaroneToxicity in Isolated Hepatocytes in Culture. Proceeding of the Society for Experimental
Biology and Medicine, 190(2), 163-169.
63.
Weghorst, C.M., Klaunig, J.E. (1989). Phenobarbital Promotion in Diethylnitrosamine-Initiated Infant
B6C3F1 Mice: Influence of Gender. Carcinogenesis, 10(3), 609-612.
64.
Weghorst, C.M., Periera, M.A, Klaunig, J.E. (1989). Strain Differences in Hepatic Tumor Promotion by
Phenobarbital in Diethylnitrosamine- and Dimethylnitrosamine-Initiated Infant Male Mice. Carcinogenesis,
10(8), 1409-1412.
65.
Diwan, B.A., Lubet, R.A., Nims, R.W., Klaunig, J.E., Weghorst, C.M., Henneman, J.R., Ward, J.M., Rice,
J.M. (1989). Lack of Promoting Effect of Clonazepam on the Development of N-NitrosodiethylamineInitiated Hepatocellular Tumors in Mice is Correlated with its Inability to Inhibit Cell-to-Cell
Communication in Mouse Hepatocytes. Carcinogenesis, 10(9), 1719-1724.
66.
Ruch, R.J., Crist, K.M., Klaunig, J.E. (1989). Effects of Culture Duration on Hydrogen Peroxide-Induced
Hepatocyte Toxicity. Toxicology and Applied Pharmacology, 100(3), 451-464.
67.
Lin, E.L., Klaunig, J.E., Weghorst, C.M., Mattox, J.K., McFarland, B.H., Pereira, M.A. (1989). Comparison
of the Effects of Acute and Subacute Treatment of Phenobarbital in Different Strains of Mice. Cancer
Letters, 48(1), 43-51.
68.
Klaunig, J.E., Weghorst, T.R., Weghorst, C.M. (1990). Liver Tumor Promoting Ability of Corn Oil Gavage
in B6C3F1 Male Mice. Cancer Letters, 50(3), 215-219.
69.
Nigrovic, V., Segal, F., Klaunig, J.E., Fry, K. (1990). The Site and Mechanism of the Cytotoxic Effect of
Atracurium In Vitro. European Journal of Anesthesiology, 7, 123-131.
70.
Xie, Z.J, Wang Y.H., Askari, A., Huang W.H., Klaunig, J.E., Askari, A. (1990). Studies on the Specificity
of the Effects of Oxygen Metabolites on Cardiac Sodium Pump. Journal of Molecular & Cellular
Cardiology, 22(8), 911-920.
71.
Somani, P., Bandyopadhyay, S., Klaunig, J.E., Gross, S.A. (1990). Amiodarone- and DesethylamiodaroneInduced Myelinoid Inclusion Bodies and Toxicity in Cultured Rat Hepatocytes. Hepatology, 11(1), 81-92.
12
72.
Bandyopadhyay, S., Klaunig, J.E., Somani, P. (1990). Cytotoxic Interactions of Cardioactive Cationic
Amphiphilic Compounds in Primary Rat Hepatocytes in Culture. Hepatology, 12 (1), 48-58.
73.
Trosko, J.E., Chang, C.C., Madhukar, B.V., Klaunig, J.E. (1990). Chemical, Oncogene, and Growth Factor
Inhibition Gap Junctional Intercellular Communication: An Integrative Hypothesis of Carcinogenesis.
Pathobiology, 58(5), 265-278.
74.
Klaunig, J.E., Ruch, R.J., Weghorst, C.M., Hampton, J.A. (1990). Role of Inhibition of Intercellular
Communication in Hepatic Tumor Promotion. In Vitro Toxicology, 3 (1), 91-107.
75.
Klaunig, J.E., Ruch, R.J. (1990). Role of Inhibition of Intercellular Communication in Carcinogenesis.
Laboratory Investigation, 62(2), 135-146.
76.
Klaunig, J.E., Ruch, R.J., Weghorst, C.M. (1990). Comparative Effects of Phenobarbital, DDT, and
Lindane on Mouse Hepatocyte Gap Junctional Intercellular Communication. Toxicology and Applied
Pharmacology, 102 (3), 553-563.
77.
De Feijter, A.W., Ray, J.S., Weghorst, C.M., Klaunig, J.E., Goodman, J.J., Chang, C.C., Ruch, R.J., Trosko,
J.E. (1990). Infection of Rat Liver Epithelial Cells with V-Ha-ras: Correlation between Oncogene
Expression, Gap Junctional Communication, and Tumorigenicity. Molecular Carcinogenesis, 3(2), 54-67.
78.
Ruch, R.J., Klaunig, J.E., Kerckaert, G.A., LeBoeuf, R.A. (1990). Modification of Gap Junctional
Intercellular Communication by Changes in Extracellular pH in Syrian Hamster Embryo Cells.
Carcinogenesis, 11(6), 909-913.
79.
Ruch, R.J., Fransson, R., Flodstrom, S., Warngard, L., Klaunig, J.E. (1990). Inhibition of Hepatocyte Gap
Junctional Intercellular Communication by Endosulfan, Chlordane, and Heptachlor. Carcinogenesis, 11(7),
1097-1101.
80.
Klaunig, J.E., Ruch, R.J., Hampton, J.A., Weghorst, C. M., Harnett, J.A. (1990). Gap Junctional Intercellular
Communication and Murine Hepatic Carcinogenesis. Progress in Clinical and Biological Research, 331,
277-291.
81.
Klaunig, J.E., Hartnett, J.A., Ruch, R.J., Weghorst, C.M., Hampton, J.A., Schaefer, L.D. (1990). Gap
Junctional Intercellular Communication in Hepatic Carcinogenesis. Progress in Clinical & Biological
Research, 340, 165-74.
82.
Goodman, J. I., Ward, J.M., Popp, J.A., Klaunig, J.E., Fox, T.R. (1991). Mouse Liver Carcinogenesis:
Mechanisms and Relevance. Fundamental and Applied Toxicology, 17(4), 651-665.
83.
Klaunig, J.E. (1991). Alterations in Intercellular Communication during the Stage of Promotion.
Proceedings of the Society for Experimental Biology and Medicine, 198(2), 688-692.
84.
Klaunig, J.E., Siglin, J.C., Schafer, L.D., Hartnett, J.A., Weghorst, C.M., Olson, M.J., Hampton, J.A. (1991).
Correlation between Species and Tissue Sensitivity to Chemical Carcinogenesis in Rodents and the Induction
of DNA Synthesis. Progress in Clinical and Biological Research, 369, 185-194.
85.
Ruch, R.J., Bandyopadhyay S., Somani, P., Klaunig, J.E. (1991). Evaluation of Amiodarone Free Radical
Toxicity in Rat Hepatocytes. Toxicology Letters, 56(1-2), 117-126.
86.
Siglin, J.C., Weghorst, C.M., Klaunig, J.E. (1991). Role of Hepatocyte Proliferation in AlphaHexachlorocyclohexane and Phenobarbital Tumor Promotion in B6C3F1 Mice. Progress in Clinical and
Biological Research, 369, 407-416.
13
87.
Klaunig, J.E., (1992). Chemopreventive Effects of Green Tea Components on Hepatic Carcinogenesis.
Preventive Medicine, 21(4), 510-519.
88.
Ruch, R.J., Klaunig, J.E. (1992). Enhancement of Rodent Hepatocyte Gap Junctional Intercellular
Communication by Dexamethasone. In Vitro Toxicology, 5(2), 103-111.
89.
Ruch, R.J., Madhukar, B.V., Trosko, J.E., Klaunig, J.E. (1993). Reversal of ras-Induced Inhibition of Gap
Junctional Intercellular Communication, Transformation, and Tumorigenesis by Lovastatin. Molecular
Carcinogenesis, 7(1), 50-59.
90.
Klaunig, J.E. (1993). Selective Induction of DNA Synthesis in Mouse Preneoplastic and Neoplastic Hepatic
Lesions after Exposure to Phenobarbital. Environmental Health Perspectives, 101(Suppl. 5), 235-239.
91.
Kwiatkowski, A.P., Baker, T.K, Klaunig, J.E. (1994). Comparison of Glucocorticoid-Mediated Changes in
the Expression and Function of Rat Hepatocyte Gap Junctional Proteins. Carcinogenesis, 15(8), 1753-1757.
92.
Mehendale, H.M., Roth, R.A., Gandolfi, A.J., Klaunig, J.E., Lemasters, J.J., Curtis, L.R. (1994). Novel
Mechanisms in Chemically Induced Hepatotoxicity. Federation of American Societies for Experimental
Biology, 8(15), 1285-1295.
93.
Jou, Y.S., Layhe, B., Matesic, D.F., Chang, C., deFeijter, A.W., Lockwood, L., Welsch, C.W., Klaunig, J.E.,
Trosko, J.E. (1995). Inhibition of Gap Junction Intercellular Communication and Malignant Transformation
of Rat Liver Epithelial Cells by Neu Oncogene. Carcinogenesis, 16(2), 311-317.
94.
Siglin, J.C., Weghorst, C.M., Rodwell, D.E., Klaunig, J.E. (1995). Gender-Dependent Differences in Hepatic
Tumor Promotion in Diethylnitrosamine Initiated Infant B6C3F1 Mice by Alpha-Hexachlorocyclohexane.
Journal of Toxicology and Environmental Health, 44(2), 235-245.
95.
Kolaja, K.L., Stevenson, D.E., Walborg, E.F. Jr., Klaunig, J.E. (1995). The Effect of Dieldrin and
Phenobarbital on Preneoplastic Hepatic Lesion Growth in Male F344 Rat and B6C3F1 Mouse. Progress in
Clinical and Biological Research, 391, 409-423.
96.
Baker, T.K., Kwiatkowski, A.P., Madhukar, B.V., Klaunig, J.E. (1995). Inhibition of Gap Junctional
Intercellular Communication by 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) in Rat Hepatocytes.
Carcinogenesis, 16(10), 2321-2326.
97.
Baker, T.K., Bachowski, S., Stevenson, D.E., Walborg, E.F. Jr., Klaunig, J.E. (1995). Modulation of Gap
Junctional Intercellular Communication in Rodent, Monkey and Human Hepatocyte by Nongenotoxic
Compounds. Progress in Clinical and Biological Research, 391, 71-80.
98.
Bachowski, S., Xu, Y., Baker, T.K., Stevenson, D.E., Walborg, E.F. Jr., Klaunig, J.E. (1995). The Potential
Role of Oxidative Stress in Nongenotoxic Carcinogenesis in the Mouse Liver. Progress in Clinical and
Biological Research, 391, 385-396.
99.
Stevenson, D.E., Kehrer, J.P., Kolaja, K.L., Walborg E.F. Jr., Klaunig, J.E. (1995). Effect of Dietary
Antioxidants on Dieldrin-Induced Hepatotoxicity in Mice. Proceedings of the Seventh International
Conference on Carcinogenesis and Risk Assessment. Toxicology Letters, 75(1-3), 177-183.
100.
Kolaja, K.J., Stevenson, D.E., Johnson, J.T., Walborg, E.F. Jr., Klaunig, J.E. (1995). Hepatic Effects of
Dieldrin and Phenobarbital in Male B6C3F1 Mice and Fisher 344 rats: Species Selective Induction of DNA
Synthesis. Progress in Clinical and Biological Research, 391, 397-408.
101.
Stevenson, D.E., Walborg, E.F. Jr., Klaunig, J.E. (1995). The Species Specificity of Dieldrin- or
Phenobarbital-Induced Hepatocarcinogenesis: Case Studies with Implications for Human Health Risk
Assessment. Progress in Clinical and Biological Research, 391, 337-345.
14
102.
Klaunig, J.E., Xu, Y., Bachowski, S., Ketcham, C.A., Isenberg, J.S., Kolaja, K.L., Baker, T.K., Walborg,
E.F. Jr., Stevenson, D.E. (1995). Oxidative Stress in Nongenotoxic Carcinogenesis. International Congress
of Toxicology. Toxicology Letters, 82-83, 683-691.
103.
Kolaja, K.L., Stevenson, D.E., Johnson, J.T., Walborg, E.F. Jr., Klaunig, J.E. (1996). Subchronic Effects of
Dieldrin and Phenobarbital on Hepatic DNA Synthesis in Mice & Rats. Fundamental and Applied
Toxicology, 29(2), 219-228.
104.
Cao, J., Xu, Y., Chen, J., Klaunig, J.E. (1996). Chemopreventive Effects of Green Tea and Black Tea on
Pulmonary and Hepatic Carcinogenesis. Fundamental and Applied Toxicology, 29(2), 244-250.
105.
Kolaja, K.L., Stevenson, D.E., Walborg, E.F. Jr., Klaunig, J.E. (1996). Reversibility of Promoter Induced
Hepatic Focal Lesion Growth in Mice. Carcinogenesis, 17(7), 1403-1409.
106.
Kolaja, K.L., Stevenson, D.E., Walborg, E.F. Jr., Klaunig, J.E. (1996). Selective Dieldrin Promotion of
Hepatic Focal Lesions in Mice. Carcinogenesis, 17(6), 1243-1250.
107.
Kolaja, K.L., Stevenson, D.E., Walborg, E.F. Jr., Klaunig, J.E. (1996). Dose Dependence of Phenobarbital
Promotion of Preneoplastic Hepatic Lesions in F344 Rats and B6C3F1 Mice: Effects on DNA Synthesis and
Apoptosis. Carcinogenesis, 17(5), 947-954.
108.
Kolaja, K.L., Bunting, K.A., Klaunig, J.E. (1996). Inhibition of Tumor Promotion and Hepatocellular
Growth by Dietary Restriction in Mice. Carcinogenesis, 17(8), 1657-1664.
109.
Steinmetz, K.L., Klaunig, J.E. (1996). Transforming Growth Factor-Alpha in Carcinogen-Induced F344 Rat
Hepatic Foci. Toxicology and Applied Pharmacology, 140(1), 131-145.
110.
Sargent, L., Dragan, Y.P., Babcock, K., Wiley, J., Klaunig, J.E., Pitot, H.C. (1996). Cytogenetic Analysis
of Three Rat Liver Epithelial Cell Lines (WBbneo, WBHa-ras, and WBraslla) and Correlation of an Early
Chromosomal Alteration with Insulin-like Growth Factor II Expression. Cancer Research, 56(13), 2992-7.
111.
Kolaja, K.L., Klaunig, J.E. (1997). Vitamin E Modulation of Hepatic Focal Lesion Growth in Mice.
Toxicology and Applied Pharmacology, 143(2), 380 - 387.
112.
Isenberg, J.S., Kolaja, K.L., Ayoubi, S.A., Watkins J.B. III, Klaunig, J.E. (1997). Inhibition of Wy-14,643
Induced Hepatic Lesion Growth in Mice by Rotenone. Carcinogenesis, 18(8), 1511-1519.
113.
Isfort, R.J., Cody, D.B., Doersen, C, Richards, W.G., Yoder, B.K., Wilkinson, J.E., Kier, L.D., Jirtle, R.L,
Isenberg, J.S., Klaunig, J.E., Woychik, R.P. (1997). The Tetratricopeptide Repeat Containing Tg737 Gene
is Liver Neoplasis Tumor Suppressor Gene. Oncogene, 15, 1797-1803.
114.
Bachowski, S., Kolaja, K.L., Xu, Y., Ketcham, C.A., Stevenson, D.E., Walborg, E.F. Jr., Klaunig, J.E.
(1997). Role of Oxidative Stress in the Mechanism of Dieldrin’s Hepatotoxicity. Annals of Clinical &
Laboratory Science, 27(3), 196-209.
115.
Bachowski, S., Xu, Y., Stevenson, D.E., Walborg, E.F. Jr., Klaunig, J.E. (1998). Role of Oxidative Stress in
the Selective Toxicity of Dieldrin in the Mouse Liver. Toxicology and Applied Pharmacology, 150(2), 301309.
116.
Klaunig, J.E., Xu, Y., Isenberg, J.S., Bachowski, S., Kolaja, K.L., Jiazhong, J., Stevenson, D.E., Walborg,
E.F. Jr. (1998). The Role of Oxidative Stress in Chemical Carcinogenesis. Environmental Health
Perspectives, 106(Suppl. 1), 289-295.
15
117.
Jiang, J., Xu, Y., Klaunig, J.E. (1998). Induction of Oxidative Stress in Rat Brain by Acrylonitrile.
Toxicological Sciences, 46(2), 333-341.
118.
Crouch, D.J., Frank, J.F., Farrell, L.J., Karsch, H.M., Klaunig, J.E (1998). A Multiple-Site Laboratory
Evaluation of Three On-Site Urinalysis Drug Testing Devices. Journal of Analytical Toxicology,
22, 493-502.
119.
Dragan, Y., Klaunig, J.E., Maronpot, R., Goldsworthy, T. (1998). Mechanisms of Susceptibility to Mouse
Liver Carcinogenesis. Toxicological Sciences, 41(1), 3-7, 1998.
120.
Kolaja, K.L., Xu, Y., Walborg, E.F. Jr., Stevenson, D.E., Klaunig, J.E. (1998). Vitamin E Modulation of
Dieldrin-Induced Hepatic Focal Lesion Growth in Mice. Journal of Toxicology & Environmental Health Part
A, 53(6), 479-492.
121.
Watkins, J.B. III, Klaunig, J.E., Smith, H.M., Cornwell, P., Sanders, R.A. (1998). Streptozotocin-Induced
Diabetes Increases Gamma-Gutamyltranspeptidase Activity but Not Expression in Rat Liver. Journal of
Biochemical and Molecular Toxicology, 12(4), 219-225.
122.
Klaunig, J.E., Xu, Y., Han, C. Kamendulis, L.M., Chen, J., Heiser, C., Gordon, M.S., Mohler E.R. III.
(1999). The Effect of Tea Consumption on Oxidative Stress in Smokers and Nonsmokers. Proceedings of the
Society for Experimental Biology and Medicine, 220 (4), 249-254.
123.
Herrman, C.E., Sanders, R.A., Klaunig, J.E., Schwarz, L.R., Watkins, J.B. III. (1999). Decreased Apoptosis
as a Mechanism for Hepatomegaly in Streptozotocin-Induced Diabetic Rats. Toxicological Sciences, 50(1),
146-151.
124.
Kamendulis, L.M., Jiang, J., Zhang, H., deFeijter-Rupp, H., Trosko, J.E., Klaunig, J.E. (1999). The Effect
of Acrylonitrile On Gap Junctional Intercellular Communication in Rat Astrocytes. Cell Biology and
Toxicology, 15(3), 173-183.
125.
Kamendulis, L.M., Jiang, J., Xu, Y., Klaunig, J.E. (1999). Induction of Oxidative Stress and Oxidative
Damage in Rat Glial Cells by Acrylonitrile. Carcinogenesis, 20, 1555-1560.
126. Lahiri, D.K., Xu, Y., Klaunig, J.E., Baiyewu, O., Ogunniyi, A., Hall, K., Hendrie, H., Sahota, A. (1999).
Effect of Oxidative Stress on DNA Damage and Beta-Amyloid Precursor Proteins in Lymphoblastoid Cell
Lines from a Nigerian Population. Annals of New York Academy of Sciences, 893, 331-336.
127.
Stevenson, D.E., Walborg, E.F. Jr., North, W.D., Sielken, R.L., Ross, C.E., Wright, A.S., Xu, Y.,
Kamendulis, L.M., Klaunig, J.E. (1999). Monograph: Reassessment of Human Cancer Risk of
Aldrin/Dieldrin. Toxicology Letters, 109 (3), 123-186.
128.
Klaunig, J.E., Kamendulis, L.M. (1999). Mechanisms of Cancer Chemoprevention in Hepatic
Carcinogenesis: Modulation of Focal Lesion Growth in Mice. Toxicological Sciences, 52 (2 Supp), 101106.
129.
Brophy, D.F., Sowinski, K.M., Kraus, M.A., Moe, S.M., Klaunig, J.E., Mueller, B.A. (1999). Small and
Middle Molecular Weight Solute Clearance in Nocturnal Intermittent Peritoneal Dialysis. Peritoneal Dialysis
International, 19(6), 534-539.
130.
Isenberg, J.S., Klaunig, J.E. (2000). Role of the Mitochondrial Membrane Permeability Transition (MPT) in
Rotenone-Induced Apoptosis in Liver Cells. Toxicological Sciences, 53(2), 340-351.
131.
Isenberg, J.S., Kamendulis, L.M., Smith, J.H., Ackley, D.C., Pugh, G. Jr., Lington, A.W., Klaunig, J.E.
(2000). Effects of Di-2 Ethlhexyl Phathalate (DEHP) on Gap Junctional Intercellular Communication
(GJIC), DNA Synthesis, and Peroxisomal Beta Oxidation (PBOX), in Rat, Mouse, and Hamster Liver.
Toxicological Sciences, 56(1), 73-85.
16
132.
Zhang, H., Kamendulis, L.M., Jiang J., Xu, Y., Klaunig, J.E. (2000). Acrylonitrile-induced Morphological
Transformation in Syrian Hamster Embryo Cells. Carcinogenesis, 21(4), 727-33.
133.
Zhang, H., Xu, Y., Kamendulis, L.M., Klaunig, J.E. (2000). Morphological Transformation by 8-hydroxy2’-deoxyguanosine in Syrian Hamster Embryo (SHE) Cells. Toxicological Sciences, 56(2), 303-312.
134.
Smith, J.H., Isenberg, J.S., Pugh, G. Jr., Kamendulis, L.M., Ackley, D., Lington, A.W., Klaunig, J.E. (2000).
Comparative In Vivo Hepatic Effects of Di-Isononyl Phthalate (DINP) and Related C7 - C11 Dialkyl
Phthalates on Gap Junctional Intercellular Communication (GJIC), Peroxisomal Beta-Oxidation (PBOX), and
DNA Synthesis in Rat and Mouse Liver. Toxicological Sciences, 54(2), 312-321.
135.
Pugh, G. Jr., Isenberg, J.S., Kamendulis, L.M., Clare, L.J., Brown, R., Lington, A.W., Smith, J.H., Klaunig,
J.E., (2000). Effects of Di-Isononyl Phthalate, Di-2-ethylhexyl Phthalate, and Clofibrate in Cynomolgus
Monkeys. Toxicological Sciences, 56(1), 181-188.
136.
Klaunig, J.E., Kamendulis, L.M., Xu, Y. (2000). Epigenetic Mechanisms of Chemical Carcinogenesis.
Human & Experimental Toxicology, 19(10), 543-555.
137.
Kingery, J.R., Sowinski, K.M., Kraus, M.A., Klaunig, J.E., Mueller, B.A. (2000). Vancomycin Assay
Performance in Patients with End-Stage Renal Disease Receiving Hemodialysis. Pharmacotherapy, 20(6),
653-656.
138.
Kamendulis, L.M., Kolaja, K.L., Stevenson, D.E., Walborg, E.F. Jr., Klaunig, J.E. (2001). Comparative
Effects of Dieldrin on Hepatic Ploidy, Cell Proliferation, and Apoptosis in Rodent Liver. Journal of
Toxicology and Environmental Health Part A, 62, 127-141.
139.
Xue, H., Aziz, R.M., Sun, N., Kamendulis, L.M., Xu, Y., Stoner, G.D., Klaunig, J.E. (2001). Inhibition of
Cellular Transformation by Berry Extracts. Carcinogenesis, 22 (2), 351-356.
140.
Gottschling, B.C., Maronpot, R.R., Hailey, J.R., Peddada, S., Moomaw, C.R., Klaunig, J.E., Nyska, A.
(2001). The Role of Oxidative Stress in Indium Phosphide-Induced Lung Carcinogenesis in Rats.
Toxicological Sciences, 64(1), 28-40.
141.
Isenberg, J.S., Kamendulis, L.M., Ackley, D.C., Smith, J.H., Pugh, Jr., G., Lington, A.W., McKee, R.H.,
Klaunig, J.E. (2001). Reversibility and Persistence of Di-2-Ethylhexyl Phthalate (DEHP) - and
Phenobarbital-Induced Hepatocellular Changes in Rodents. Toxicological Sciences, 64(2), 192-199.
142.
Park, J., Kamendulis, L.M., Friedman, M.A., Klaunig, J.E. (2002). Acrylamide-Induced Cellular
Transformation. Toxicological Sciences, 65(2), 177-183.
143.
Park, J., Kamendulis, L.M., Klaunig, J.E. (2002). Effects of 2-Butoxyethanol on Hepatic Oxidative
Damage. Toxicology Letters, 126(1), 19-29.
144.
Zhang, H., Kamendulis, L.M., Klaunig, J.E. (2002). Mechanisms for the Induction of Oxidative Stress in
Syrian Hamster Embryo cells by Acrylonitrile. Toxicological Sciences, 67(2), 247-255.
145.
Park, J., Kamendulis, L.M., Klaunig, J.E. (2002). Mechanisms of 2-Butoxyethanol Carcinogenicity:
Studies on Syrian Hamster Embryo (SHE) Cell Transformation. Toxicological Sciences, 68(1), 43-50.
146.
Kamendulis, L.M., Zhang, H., Wang, Y., Klaunig, J.E. (2002). Morphological Transformation and
Oxidative Stress Induced by Cyanide in Syrian Hamster Embryo (SHE) Cells. Toxicological Sciences, 68(2),
437-443.
147.
Siesky, A.M., Kamendulis, L.M., Xu, Y., Klaunig, J.E. (2002). Hepatic Effects Of 2-Butoxyethanol in
Rodents. Toxicological Sciences, 70(2), 252-260.
17
148.
Kamendulis, L.M., Isenberg, J.S., Smith, J.H., Pugh, G. Jr., Lington, A.W., Klaunig, J.E. (2002).
Comparative Effects of Phthalate Monoesters on Gap Junctional Intercellular Communication and
Peroxisome Proliferation in Rodent and Primary Hepatocytes. Journal of Toxicology and Environmental
Health Part A, 65(8), 569-588.
149.
Teuschler, L., Klaunig, J.E., Carney, E., Chambers, J., Conolly, R., Gennings, C., Giesy, J., Hertzberg, R.,
Klaassen, C., Kodell, R., Paustenbach, D., Yang, R. (2002). Support of Science-Based Decisions Concerning
the Evaluation of the Toxicology of Mixtures: A New Beginning. Regulatory Toxicology and Pharmacology,
36(1), 34-39.
150.
Lin, S., Wei, X., Xu, Y., Yan, C., Dodel, R., Zhang, Y., Liui, J., Klaunig, J.E., Farlow, M., Du, Y. (2003).
Minocycline Blocks 6-Hydroxydopamine-Induced Neurotoxicity and Free Radical Production in Rat
Cerebellar Granule Neurons. Life Sciences, 72(14), 1635-1641.
151.
Cohen, S.M., Meek, M.E., Klaunig, J.E, Patton, D.E., Fenner-Crisp, P.A. (2003) The Human Relevance of
Information on Carcinogenic Modes of Action: Overview. Critical Reviews in Toxicology, 33(6), 581-589.
152.
Klaunig, J.E, Babich, M.A., Baetcke, K.P., Cook, J.C., Corton, J.C., David, R.M., DeLuca, J.G., Lai, D.Y.,
McKee, R.H., Peters, J.M., Roberts, R.A., Fenner-Crisp, P.A. (2003). PPAR-alpha Agonist-Induced Rodent
Tumors: Modes of Action and Human Relevance. Critical Reviews in Toxicology, 33(6), 655-780.
153.
Klaunig, J.E., Kamendulis, L.M. (2004). The Role of Oxidative Stress in Carcinogenesis. Annual Review
of Pharmacology and Toxicology, 44, 239-267.
154.
Cohen, S.M., Klaunig, J.E., Meek, M.E., Hill, R.N., Pastoor, T., Lehman-McKeeman, L., Bucher, J.,
Longfellow, D.G., Seed, J., Dellarco, V., Fenner-Crisp, P., Patton, D. (2004). Evaluating the Human
Relevance of Chemically Induced Animal Tumors. Toxicological Sciences, 78(2), 181-186.
155.
Chirase N.K., Green L.W., Purdy C.W., Loan R.W., Auvermann B.W., Parker D.B., Walborg E.F. Jr.,
Stevenson, D.E., Xu Y., Klaunig J.E. (2004). Effect of Transport Stress on Respiratory Disease, Serum
Antioxidant Status, and Serum Concentrations of Lipid Peroxidation Biomarkers in Beef Cattle. American
Journal of Vet. Research, 65(6), 860-864.
156.
Rusyniak, D.E., Tandy, S.L., Kamendulis, L.M., Sprague, J.E., Klaunig, J.E. (2004). The Effects of Ecstasy
(MDMA) on Rat Liver Bioenergetics. Academic Emergency Medicine, 11(7), 723-29.
157.
Boatman, R.J., Corley R.A., Green, T., Klaunig J.E., Udden, M.M. (2004). Review of Studies
Concerning the Tumorigenicity of 2-Butoxyethanol in B6C3F1 Mice and its Relevance for Human Risk
Assessment. Journal of Toxicology and Environmental Health, Part B: Critical Reviews, 7(5), 385-398.
158.
Lafferty, J.S., Kamendulis, L.M., Kaster, J., Jiang, J., Klaunig, J.E. (2004). Subchronic Acrylamide
Treatment Induces a Tissue-Specific Increase in DNA Synthesis in the Rat. Toxicology Letters, 154 (1-2),
95-103.
159.
Klaunig, J.E., Kamendulis, L.M. (2005). Mode of Action of Butoxyethanol-Induced Mouse Liver
Hemangiosarcomas and Hepatocellular Carcinomas. Toxicology Letters, 156(1), 107-115.
160.
Klaunig, J.E., Kamendulis, LM. (2005). Mechanisms of Acrylamide Induced Rodent Carcinogenesis.
Advances in Experimental Medicine and Biology, 561, 49-62.
161.
Kamendulis, L.M., Klaunig, J.E. (2005). Species Differences in the Induction of Hepatocellular DNA
Synthesis by Diethanolamine. Toxicological Sciences, 87(2), 328-36.
18
162.
Nie, Y, Schoepp, D.D, Klaunig, J.E., Yard, M., Lahiri, D.K., Kubek, M.J. (2005). Thyrotropin-Releasing
Hormone (Protirelin) Inhibits Potassium-Stimulated Glutamate and Aspartate Release From Hippocampal
Slices in Vitro. Brain Research, 1054(1), 45-54.
163.
Kirman, C.R., Gargas, M.L., Marsh, G.M., Strother, D.E., Klaunig, J.E., Collins, J.J., Deskin, R. (2005).
Cancer Dose – Response Assessment to Acrylonitrile Based Upon Rodent Brain Tumor Incidence: Use of
Epidemiology, Mechanistic, and Pharmacokinetic Support for Nonlinearity. Regulatory Toxicology and
Pharmacology, 43(1), 85-103.
164.
Shankar, S.S., Dube, M.P., Gorski, J.C., Klaunig, J.E., Steinberg, H.O. (2005). Indinavir Impairs
Endothelial Function in Healthy HIV-Negative Men, American Heart Journal, 150(5), 933-943.
165.
Klaunig, J.E. (2005). Cancer Biology and Hormesis. Critical Reviews in Toxicology. 35(6), 593-594.
166.
Seed, J., Carney, E.W., Corley, R.A., Crofton, K.M., DeSesso, J.M., Foster, P.M., Kavlock, R., Kimmel, G.,
Klaunig, J.E., Meek, M.E., Preston, R.J., Slikker, W. Jr., Tabacova, S., Williams, G.M., Wiltse, J., Zoeller,
R.T., Fenner-Crisp, P., Patton, D.E., (2005). Using Mode of Action and Life Stage Information to Evaluate
the Human Relevance of Animal Toxicity. Critical Reviews in Toxicology. 35(8-9), 664-672.
167.
Holsapple, M.P, Pitot, H.C., Cohen, S.H., Boobis, A.R, Klaunig, J.E., Pastoor, T., Dellarco, V.L. (2006).
Mode of Action in Relevance of Rodent Liver Tumors to Human Cancer Risk. Toxicological Sciences 89(1),
51-56.
168.
Corthals, S., Kamendulis, L.M., Klaunig, J.E., (2006). Mechanisms of 2-Butoxyethanol-Induced
Hemangiosarcomas. Toxicological Sciences. 92(2), 378-386.
169.
Pu, X., Kamendulis, L.M., Klaunig, J.E. (2006). Acrylonitrile-Induced oxidative DNA damage in rat
astrocytes. Environmental and Molecular Mutagenesis. 47, 631-638.
170.
Roberts, R.A., Ganey, P.E., Ju, C., Kamendulis, L.M., Rusyn, I. Klaunig, J.E. (2007). Role of the Kupffer
cell in mediating hepatic toxicity and carcinogenesis. Toxicological Sciences 96(1), 2-15.
171.
Klaunig J.E., Babich, M.A., Cook, J.C., David, R.M., DeLuca, J.G., McKee, R.H., Peter, J.M., Roberts,
R.A., Fenner-Crisp, P.A. (2007). PPAR alpha and effects of TCE. Environmental Health Perspectives. 115:1,
A14 – A15.
172.
Calabrese, E.J., Mattson, M. P., Klaunig, J.E., et al. (2007). Biological stress response terminology:
Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response
framework. Journal of Toxicology and Applied Pharmacology. 222, 122-128.
173.
Hahn, N.M., Kelley, M.R., Klaunig, J.E., Koch M.O., Li, L., Sweeney C.J. (2007). Constitutional
Polymorphisms of Prostate Cancer: Prognostic and Diagnostic Implications. Future Oncology. 3 (6), 665682.
174.
Novotny, N.M., Grosfeld, J.L., Turner, K.E., Rescorla, F. J., Pu, X., Klaunig, J.E., Hickey, R.J., Malkas,
L.H., Sandoval, J.A. (2008). Oxidative status in neuroblastoma: A source of stress? Journal of Pediatric
Surgery. 43(2), 330-334.
175.
Klaunig, J.E. (2008). Acrylamide carcinogenicity. Journal of Agricultural and Food Chemistry. 56(15),
5984-5988.
176.
DePeyster, A., Rodriguez, Y., Shuto, R., Goldberg, B., Gonzales, F., Pu, X., Klaunig, J.E. (2008). Effect of
oral methyl-t-butyl ether (MTBE) on the male mouse reproductive tract and oxidative stress in liver.
Reproductive Toxicology, 26(3-4), 246-253.
19
177.
Klaunig, J.E., Shi, Y. (2009). Gap-Junctional Intercellular Communication. In Current Protocols in
Toxicology. Chapter 2: Unit 2.17.
178.
Harvilchuck, J.A., Pu, X., Klaunig, J.E., Carlson, G. (2009). Indicators of oxidative stress and apoptosis in
mouse whole lung and clara cells following exposure to Styrene and its metabolites. Toxicology,
264(3):171-178.
179.
Pu, X., Kamendulis, L.M., Klaunig, J.E. (2009). Acrylonitrile-induced oxidative stress and oxidative DNA
damage in male Sprague-Dawley Rats. Toxicological Sciences, 111(1), 64-71. PMC2726299
180.
Lee, L., Alloosh, M., Saxena, R., Van Alstine, W., Watkins, B., Klaunig, J.E., Sturek, M., Chalasani, N.
(2009). Nutritional model of steatohepatitis and metabolic syndrome in the Ossabaw Island miniature swine.
Hepatology. 50(1), 56-67.
181.
Cohen, S.M., Storer, R.D., Criswell, K.A., Doerrer, N.G., Dellarco, V.L., Pegg, D.G. Wojcinski, Z.W.,
Malarkey, D.E., Jacobs, A.C., Klaunig, J.E., Swenberg, J.A., Cook, J.C. (2009). Hemangiosarcoma in
rodents: Mode-of-action evaluation and human relevance. Toxicological Sciences 111(1), 4-18.
182.
Klaunig, J.E., Kamendulis, L.M., Hocevar, B.A. (2010). Oxidative stress and damage in carcinogenesis.
Tox. Path. 2010; 38:96-109.
183.
Zhang, X.F., Tan, X., Zeng, G., Misse, A., Singh, S., Kim, Y., Klaunig, J.E., Zucman-Rossi, Monga, S.P.S.
(2010) Conditional β-Catenin loss in mice promotes chemical hepatocarcinogenesis: Role of oxidative stress
& PDGFRα/PIK3CA signaling. Hepatology. 52(3):954-65.
184.
Meek, M.E., Klaunig, J.E. (2010). Proposed mode of action of benzene induced leukemia: Interpreting
available data and identifying critical data gaps for risk assessment. Chemico-Biological Interactions. 184(12):279-85.
185.
Kamendulis, L.M., Corthals, S.M., Klaunig, J.E. (2010). Kupffer cells participate in 2-butoxyethanolinduced liver hemangiosarcomas. Toxicology, 270(2-3):131-6.
186.
Rhomberg, L.R., Goodman, J.E., Haber, L.T., Dourson, M., Andersen, M.E., Klaunig J.E., Meek, B., Price,
P.S., McClellan, R.O., Cohen, S.M. (2011). Linear low-dose extrapolation for noncancer health effects is the
exception, not the rule. Critical Reviews in Toxicology. 2011 Jan; 41(1):1-21.
187.
Shanmugan, R., Kusumanchi, P., Appaiah, H., Cheng, L., Crooks, P., Neelakantan, S., Peat, T., Klaunig,
J.E., Mattews, W., Naksharti, H, Sweeney, C.J. (2011). A water soluble parthenolide analog suppresses in
vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-кB and
generating reactive oxygen species. International Journal of Cancer, 128: 2481–2494.
188.
Fullenkamp AM, Bell LN, Robbins RD, Lee L, Saxena R, Alloosh M, Klaunig J.E., Mirmira RG, Sturek M,
Chalasani N. (2011). Effect of Different Obesogenic Diets on Pancreatic Histology in Ossabaw Miniature
Swine. Pancreas, 40 (3), 438-43.
189.
Vuppalanchi, R., Juluri, R., Bell, L., Ghabril, M., Kamendulis, L., Klaunig, J.E., Saxena, R., Agrawal, D.,
Johnson, M.S., Chalasani, N. (2011). Oxidative stress in chronic liver disease: Relationship between
peripheral and hepatic measurements. American Journal of Medical Science. 2011 Oct;342(4):314-7.
190.
Klaunig, J. E., Wang, Z., Pu, X., Zhou, S. (2011). Oxidative Stress and Oxidative Damage in Chemical
Carcinogenesis. Toxicology and Applied Pharmacology 254:86-99
190
Klaunig JE, Hocevar BA, Kamendulis LM. (2012). Mode of Action analysis of perfluorooctanoic acid
(PFOA) tumorigenicity and Human Relevance. Reproductive Toxicology. Jul;33(4):410-8
20
191
Kushida M, Kamendulis LM, Peat TJ, Klaunig JE. (2011). Dose-related induction of hepatic preneoplastic
lesions by diethylnitrosamine in C57BL/6 mice. Toxicol Pathol. 39(5):776-86.
192
Klaunig JE, Hocevar BA, Kamendulis LM. (2012). Mode of Action analysis of perfluorooctanoic acid
(PFOA) tumorigenicity and Human Relevance. Reproductive Toxicology. Jul;33(4):410-8
193
Conroy SK, McDonald BC, Smith DJ, Moser LR, West JD, Kamendulis LM, Klaunig JE, Champion VL,
Unverzagt FW, Saykin AJ. (2013). Alterations in brain structure and function in breast cancer survivors:
effect of post-chemotherapy interval and relation to oxidative DNA damage. Breast Cancer Res Treat.
Jan;137(2):493-502
194
Owumi SE, Corthals SM, Uwaifo AO, Kamendulis LM, Klaunig JE. (2014). Depletion of Kupffer cells
modulates ethanol-induced hepatocyte DNA synthesis in C57Bl/6 mice. Environ Toxicol. 2014
Aug;29(8):867-75
195
Stagg NJ, Lebaron MJ, Eisenbrandt DL, Gollapudi BB, Klaunig JE. (2012). Assessment of possible
carcinogenicity of oxyfluorfen to humans using mode of action analysis of rodent liver effects. Toxicological
Sciences. 2012 Aug;128(2):334-45.
196
Corton JC, Cunningham ML, Hummer BT, Lau C, Meek B, Peters JM, Popp JA, Rhomberg L, Seed J,
Klaunig JE. (2013) Mode of action framework analysis for receptor-mediated toxicity: The peroxisome
proliferator-activated receptor alpha (PPARa) as a case study. Critical Reviews in Toxicology . Crit Rev
Toxicol. 2014 Jan;44(1):1-49.
197
Zhou S, Wang Z, Klaunig JE. (2013) Caenorhabditis elegans neuron degeneration and mitochondrial
suppression caused by selected environmental chemicals. Int J Biochem Mol Biol. Dec 15;4(4):191-200.
198
Burns, C.J., Wright, J.M., Pierson, J.B., Bateson, T.F., Burstyn, I., Goldstein, D.A., Klaunig, J.E., Luben,
T.J., Mihlan, G., Ritter, L., Schnatter, A.R., Symons, J.M., Yi, K.D. (2014) Evaluating Uncertainty to
Strengthen Epidemiologic Data for Use in Human Health Risk Assessments. Environmental Health
Perspectives. July 31. DOI: DOI:10.1289/ehp.1308062
199
Engström, W., Darbre , P., Eriksson, S., Gulliver,L., Hultman, T., Karamouzis, M., Klaunig, J.E., Mehta, R.
(2014) Assessing the Carcinogenic Potential of Low Dose Exposures to Chemical Mixtures in the
Environment: Sustained Proliferative signaling. Carcinogenesis. (in press)
200
Wang, Z.Y, Burlak, C., Klaunig, J.E., Kamendulis, L. M. (2014) Development of a cytokine-producing
immortalized murine Kupffer cell line. Cytokine. August 16. DOI: 10.1016/j.cyto.2014.07.251 (in press)
201
Burns, C.J., Wright, J.M., Pierson, J.B., Bateson, T.F., Burstyn, I., Goldstein, D.A., Klaunig, J.E., Luben,
T.J., Mihlan, G., Ritter, L., Schnatter, A.R., Symons, J.M., Yi, K.D. (2014) Evaluating Uncertainty to
Strengthen Epidemiologic Data for Use in Human Health Risk Assessments. Environmental Health
Perspectives. July 31. DOI: DOI:10.1289/ehp.1308062
203
Hocevar, B.A., Kamendulis, L.M., Pu, X., Perkins, S.M., Wang, Z-Y., Johnston, E.L., DeWitt, J.M., Li, L.,
Loehrer, P.J., Klaunig, J.E., Chiorean, G. (2014). Contribution of Environment and Genetics to Pancreatic
Cancer Susceptibility. PLoS ONE, 9, 1-8.
204
Klaunig, J.E., Sinohara, M., Iwai, H., Chengelis, C.P., Kirkpatrick, J.B., Wang, Z., Bruner, R.H. (2014).
Evaluation of the Chronic Toxicity and Carcinogenicity of Perfluorohexanoic Acid (PFHA) in SpragueDawley Rats. Toxicologic Pathology. May 28, XX:1-12. DOI: 10.1177/0192623314530532 (in press)
205
Cohen SM, Arnold LL, Klaunig JE, Goodman JI. (2014) Re: Waalkes et al.: Lung tumors in mice induced by
"whole-life" inorganic arsenic exposure at human-relevant doses, Arch Toxicol. 2014 Aug 12. [Epub ahead
of print
21
206
DeLaurentis P.C. Klaunig, JE. (2013) Cancer Care Engineering: A Knowledge Acquisition Framework to
Guide the Deliberate Innovation of Treatment for Those Afflicted by a Complex Disease. International
Journal of Medical Informatics (submitted).
CHAPTERS AND BOOKS
1.
Hinton, D.E., Lipsky, M.M., Klaunig, J.E., Kolaja, G.J. (1982). Hepatic Morphology of the Lesser Bushbaby
(Galago): A Light and Electron Microscopic Study. In D.E. Haines (Ed.), The Lesser Bushbaby (Galago) As
An Animal Model: Selected Topics (pp. 231-246). Boca Raton: CRC Press.
2.
Stoner, G.D., Klaunig, J.E. (1983). Selective Isolation of Epithelial Cells in Primary Explant Cultures of
Human and Animal Tissues. In T.G. Pretlow and T.P. Pretlow (Eds.), Cell Separation: Methods and Selected
Applications (Vol. 2).
3.
Klaunig, J.E. (1983). Primary Culture of Mouse Hepatocytes: Effects of Insulin and Dexamethasone. In
R.A. Harris and N.W. Corwell (Eds.), Isolation, Characterization, and Use of Hepatocytes (pp.93-97). New
York: Elsevier Science.
4.
Kreimer-Birnbaum, M., Klaunig, J.E., Keck, R., Goldblatt, P.J., Britton, S.L., Selman, S.H. (1984). Studies
With Hematoporphyrin Derivative in Transplantable Urothelial Tumors. In A. Andreoni and R. Cubeddu
(Eds.), Porphyrins in Tumor Phototherapy (pp. 235-241).
5.
Kreimer-Birnbaum, M., Baumann, J.L., Klaunig, J.E., Keck, R., Goldblatt, P.J., Selman, S.H. (1984).
Chemical Studies with Hematoporphyrin Derivative in Bladder Cell Lines. In D.R. Doiron and C.J. Gomer
(Eds.), Porphyrin Localization and Treatment of Tumors (pp. 335-350). New York: Alan R. Liss.
6.
Hampton, J.A., Klaunig, J.E., Goldblatt, P.J. (1988). Ultrastructure of Hepatic Tumors in Teleosts. In P.
Motta (Ed.), Biopathology of the Liver: A Test Atlas of Fine Structure (pp. 167-175). Lancaster: MTP Press.
7.
Klaunig, J.E., Ruch, R.J., Hampton, J.A., Weghorst, C.M., Hartnett, J.A. (1989). Gap-Junctional Intercellular
Communication and Murine Hepatic Carcinogenesis. In F. Becker and T. Slaga (Eds.), Proceedings of
Experimental Tumor Biology. San Diego: Academic Press.
8.
Klaunig, J.E., Hartnett, J.A., Ruch, R.J., Weghorst, C.M., Hampton, J.A., Schafer, L.D. (1989). Gap
Junctional Intercellular Communication in Hepatic Carcinogenesis. Proceedings of the Fifth ICEM
(International Conference on Environmental Mutagens). New York: Alan Liss.
9.
Klaunig, J.E., Ruch, R.J. (1990). Role of Inhibition of Intercellular Communication in Carcinogenesis. In E.
Rubin and I. Damjanov (Eds.), Pathology Reviews 1990 (pp. 205-216). Clifton: Humana Press.
10.
Klaunig, J.E., Siglin, J.C., Schafer, L.D., Hartnett, J.A., Weghorst, C.M., Olson, M.J., Hampton, J.A. (1991).
Correlation between Species and Tissue Sensitivity to Chemical Carcinogenesis in Rodents and the Induction
of DNA Synthesis. In Chemically Induced Cell Proliferation: Implications for Risk Assessment (pp. 185194), Wiley-Liss.
11.
Siglin, J.C., Weghorst, C.M., Klaunig, J.E. (1991). Role of Hepatocyte Proliferation in Hexachlorocyclohexane and Phenobarbital Tumor Promotion in B6C3F1 Mice. In Chemically Induced Cell
Proliferation: Implication for Risk Assessment (pp.407-416), Wiley-Liss.
22
12.
Klaunig, J.E., Baker, T.K. (1994). Morphological Evaluation of Gap Junctional Intercellular
Communication. In Methods in Toxicology (Vol. 1B) (pp. 72-80). San Diego: Academic Press.
13.
Klaunig, J.E., Xu, Y., Bachowski, S., Jiang, J. (1997). Free-Radical Oxygen-Induced Changes in Chemical
Carcinogenesis. In K.B. Wallace (Ed.), Free Radical Toxicology (pp. 375-400). Philadelphia: Taylor and
Francis.
14.
Whitford, F., Fuhremann, T., Rao, K.S., Arce, G., Klaunig, J.E. (1997). Pesticide Toxicology: Evaluating
Safety and Risk. Purdue Pesticide Program, Purdue University Cooperative Extension Service.
15.
Klaunig, J.E., Kolaja, K.L. (1998). Chemically Induced Hepatocarcinogenesis. In G.L. Plea and W. R.
Hewitt (Eds.), Toxicology of the Liver (pp. 93-121). Philadelphia: Taylor and Francis.
16.
Jiang, J., Klaunig, J.E. (1999). Cell Contact and Cell Communication. In V.W. Pentreath (Ed.),
Neurotoxicity In Vitro (pp. 197–209). Philadelphia: Taylor and Francis.
17.
Klaunig, J.E. (1999). Low Level Exposures: Implications for Regulatory Agencies – Summary and
Comments, BELLE Newsletter, 8(1), 24.
18.
Klaunig, J.E. (2000). Epigenetic Mechanisms of Chemical Carcinogenesis. In Chemical Carcinogenesis:
Epigenetic Mechanisms and Dose Response, BELLE Newsletter, 9(1), 2-21.
19.
Klaunig, J.E., Kamendulis, L.M. (2001). Role of Oxidative Stress in Chemical Carcinogenesis. In Fuchs and
Packer (Eds.), Environmental Stressors (pp.81-102). New York: Marcel Dekker.
20.
Klaunig, J.E., Kamendulis, L.M. (2005). Mechanisms of Acrylamide Induced Rodent Carcinogenesis. In:
Friedman and Mottram (Eds.), Chemistry and Safety of Acrylamide in Food (pp. 49 – 62). Springer, New
York.
21.
Klaunig, J.E., Corthals, S. M., Kamendulis, L.M., Philip, B.K. (2007). Role of the Kupffer Cell in
Hepatoxicity and Hepatocarcinogenesis. In Sahu (Ed.) Hepatotoxicity: From Genomics to in vitro and in
vivo Models. (pp. 313-340). West Sussex, England: John Wiley & Sons, Ltd.
22.
Klaunig, J.E., Kamendulis, L.M. (2007). Chapter 8: Chemical Carcinogenesis. In Klaassen (Ed.), Casarett &
Doull’s Toxicology: The Basic Science of Poisons (7th Edition). (pp. 329-380). New York: McGraw-Hill.
23.
Klaunig, J. E. and L. M. Kamendulis (2010). Carcinogenicity. In Comprehensive Toxicology. A. M.
Charlene. Oxford, Elsevier: 117-138.
24.
Klaunig, J. E. (2010). Rodent Hepatocarcinogenesis. In Cancer Risk Assessment (eds C.-H. Hsu and T.
Stedeford), John Wiley & Sons, Inc., Hoboken, NJ, USA. Chapter 16.
25.
Klaunig, J.E., (2013). Chapter 8: Chemical Carcinogenesis. In Klaassen (Ed.), Casarett & Doull’s
Toxicology: The Basic Science of Poisons (8th Edition). (pp. 330-390). New York: McGraw-Hill.
26.
Klaunig, J.E., (2014). Carcinogenesis. In Principles of Toxicology: Environmental and Industrial
Applications (Third Edition). Roberts SM, James RC, and Williams PL, Eds., John Wiley & Sons, New York.
27.
Klaunig, J.E., (2014). Carcinogenesis and Mutagenesis. In Encyclopedia of Toxicology. John Wiley & Sons,
New York.
28.
Fly, A and Klaunig, J.E. (2014). Cancer During Childhood. In Encyclopedia of Primary Prevention and
Health Promotion. Springer Science and Business Media, New York.
23
ABSTRACTS:
1.
Klaunig, J.E., Koepp, S. (1976). Histopathology of Selected Mummichog (Fundulus Heteroclitus) Tissues
Following Acute Intoxication With Mercury - A Light and Electron Microscopical Study. Bulletin of the New
Jersey Academy of Science, 29, 37.
2.
Klaunig, J.E., Koepp, S. (1976). Electron Microscopic Examination of the Mummichog (Fundulus
Heteroclitus) Respiratory Epithelium Following Acute Exposure to Mercury. Proceedings of the 34th Annual
Electron Microscopy Society of America Meeting, 34, 274-275.
3.
Klaunig, J.E. (1976). Some Histological And Electron Microscopical Observations of Acute Mercuric
Chloride Poisoning in Fundulus Heteroclitus. M.S. Thesis, Montclair State College.
4.
Hinton, D.E., Klaunig, J.E., Lipsky, M.M. (1977). PCB-Induced Alterations in Teleost Liver: A Model for
Environmental Disease in Fish. Second Annual Eastern Fish Health Workshop, Easton, Maryland
5.
Lipsky, M.M., Klaunig, J.E., Hinton, D.E. (1977). Effects of Acute Exposure to PCB on the Hepatic MixedFunction Oxidative System of the Channel Catfish (Ictalurus Punctatus): A Biochemical and Ultrastructural
Study. International Symposium on Pathobiology of Environmental Pollutants, Storrs, Connecticut.
6.
Hinton, D.E., Klaunig, J.E., Lipsky, M.M., Jack, R., Kahng, M.W., Sanefuji, H., Jones, R.T., Trump, B.F.
(1978). Chemical Carcinogenesis in Fish: Induction of Hepatic Drug Metabolizing Enzymes and Bacterial
Mutagenesis with Polycyclic Aromatic Hydrocarbons (PAH). Symposium on Carcinogenic Polynuclear
Aromatic Hydrocarbons in the Marine Environment, Gulf Breeze, Florida.
7.
Klaunig, J.E., Goldblatt, P.J., Hinton, D.E., Lipsky, M.M., Trump, B.F. (1979). Isolation and Primary
Culture of Mouse Liver Cells. Conference on Differentiation and Carcinogenesis on Liver Cell Cultures, Nyas,
New York, New York.
8.
Hinton, D.E., Klaunig, J.E., Jack, R.M., Lipsky, M.M., Trump, B.F. (1979). Carcinogen Metabolism in Liver
MFOS of Channel Catfish (Ictalurus Punctatus) Resulting in Macromolecular Binding and Bacterial
Mutagenesis. Fourth Aquatic Toxicology Symposium, Chicago, Illinois.
9.
Hinton, D.E., Lipsky, M.M., Klaunig, J.E., Trump, B.F. (1980). Correlated Biochemical and Morphological
Analysis of Liver Alterations in Balb/c Mice during Chronic Safrole Exposure. American Association of
Anatomists, Omaha, Nebraska.
10.
Klaunig, J.E. (1980). Mouse Liver Cell Culture: Isolation, Primary Culture and Application to
Carcinogenesis Studies. Ph.D. Dissertation, Dissertation Abstracts, University of Maryland.
11.
Lipsky, M.M., Hinton, D.E., Klaunig, J.E., Trump, B.F. (1980). A New Histochemical Marker for
Carcinogen Induced Premalignant and Malignant Hepatocellular Alterations in Mice. American Association
of Cancer Research, San Diego, California.
12.
Sato, T., Tanaka, J., Kamiyama, Y., Klaunig, J.E., Cowley, R.A., Trump, B.F. (1980). Serum Ornithine
Carbamoyltransferase (S-Oct) Activity and Hepatic Mitochondria In Rats Following Live E. coli Injection.
Third Annual Conference on Shock, Lake of the Ozarks, Missouri.
13.
Klaunig, J.E., Goldblatt, P.J. (1980). Teleost Liver Cell Culture: Methods for Isolation and Application in
Toxicity and Carcinogenicity Studies. Fifth Annual Eastern Fish Health Workshop, Leetown, West Virginia.
24
14.
Jones, R.T., Klaunig, J.E., Hinton, D.E. (1980). Fish Organ Explants: A Technique for Studying Fish
Diseases. Fifth Annual Eastern Fish Health Workshop, Leetown, West Virginia.
15.
Stoner, G.D., Babcock, M., Klaunig, J.E., Goldblatt, P.J. (1981). Neoplastic Transformation of Rat
Esophageal Epithelial Cells with N-Nitrosomethylbenzylamine. American Association for Cancer Research
Proceedings, Washington, D.C.
16.
Costantini, M.G., Klaunig, J.E., Goldblatt, P.J. (1981). Differential Effects of Cyclohexamide on Protein and
RNA Synthesis in Primary Cultures of Rat Hepatocytes. 32 nd Annual Meeting of the Tissue Culture
Association, Washington, D.C.
17.
Knipe, S.M., Klaunig, J.E., Gunning, W.T., Goldblatt, P.J. (1981). Ultrastructural Observations of Mouse
Hepatocytes in Primary Culture. Micron, 12, 209-211.
18.
Klaunig, J.E., Barut, B.A., Goldblatt, P.J. (1981). Preliminary Studies on the Usefulness of Medaka Eggs in
Carcinogenicity Studies. Symposium on the Use of Small Fish Species in Carcinogenicity Testing, National
Cancer Institute, Washington, D.C.
19.
Klaunig, J.E., Costantini, M.G., Goldblatt, P.J. (1981). Establishment of Fish Hepatocyte Cultures for Use in
In Vitro Carcinogenicity Studies. Symposium on the Use of Small Fish Species in Carcinogenicity Testing,
National Cancer Institute, Washington, D.C.
20.
Klaunig, J.E., Constantini, M.G., Barut, B.A., Goldblatt, P.J. (1982). In Vitro Carcinogenesis in Canine
Bladder. International Academy of Pathology, Boston, Massachusetts.
21.
Constantini, M.G., Klaunig, J.E., Goldblatt, P.J. (1982). DNA Repair Synthesis in Isolated Liver Nuclei
Exposed to Bleomycin and MNU. American Association for Cancer Research Proceedings, St. Louis,
Missouri.
22.
Marino, M.R., Klaunig, J.E., Stoner, G.D. (1982). Cryopreservation of Trachea, Esophagus and Bladder
Tissue in Liquid Nitrogen. American Association of Cell Biology, Baltimore, Maryland.
23.
Selman, S.H., Klaunig, J.E., Birnbaum, M., Bauman, J., Goldblatt, P.J. (1982). The Treatment of
Transplantable Fanft-Induced Urothelial Tumors with Hematoporphyrin Derivative and Light: An In Vivo
And In Vitro Analysis. North Central Section of the American Urologic Association, Florida.
24.
Barut, B.A., Klaunig, J.E. (1982). Methodology for Isolation and Culture of Teleost Hepatocytes.
International Symposium on Isolation, Characterization and Use of Hepatocytes, Indianapolis, Indiana.
25.
Klaunig, J.E. (1982). Isolation and Primary Culture of Mouse Hepatocytes. International Symposium on
Isolation, Characterization and Use of Hepatocytes, Indianapolis, Indiana.
26.
Kreimer-Birnbaum, M., Baumann, J.L., Klaunig, J.E., Selman, S.H., Keck, R., Goldblatt, P.J. (1983).
Chemical Studies with Hematoporphyrin Derivative in A Bladder Cell Line. The Clayton Foundation
Symposium on Porphyrin Localization and Treatment of Tumors, Santa Barbara, California.
27.
Klaunig, J.E., Rush, R., Krall, C., Morse, D., Goldblatt, P.J. (1984). Morphology of Liver Tumors in Brown
Bullhead Catfish (Ictalurus Nebulosus). Tenth Annual Northwestern Ohio Electron Microscopy Society,
Toledo, Ohio. Micron and Microscopica Acta, 15(2), 111-112.
28.
Shulok, J., Klaunig, J.E., Schafer, P.J., Selman, S.H., Goldblatt, P.J. (1984). Ultrastructural Changes in
Transplanted Transitional Cell Carcinoma Following Treatment with Hematoporphyrin Derivative (HPD).
Tenth Annual Northwestern Ohio Electron Microscopy Society, Toledo, Ohio. Micron and Microscopica
Acta, 15(2), 121-122.
25
29.
Burns, R.A., Klaunig, J.E., Shulok, J.R., Goldblatt, P.J., Davis, W.J. (1984). Effects of Hematoporphyrin
Derivative on 7, 12 DMBA Induced Carcinogenesis in the Hamster Cheek Pouch. American Academy of Oral
Pathology, Boston, Massachusetts.
30.
Klaunig, J.E., Greisiger, E.A., Stoner, G.D. (1984). Development of a Hybrid Mouse Lung/Liver Bioassay
for Chemical Carcinogens. American Association for Cancer Research Proceedings, 25, 79.
31.
Lacher, D.A., Klaunig, J.E., Satkowiak, L.J., Knor, L.M., Sensitzer, D. (1984). A Simple Cation Exchange
Paper Method to Detect Serum Induced Ornithine Decarboxylase Activity. American Association for Clinical
Chemistry. Clinical Chemistry, 30(6), 1061.
32.
Dixit, R., Schut, H.A.J., Klaunig, J.E., Stoner, G.D. (1984). In Vitro Metabolism of Dinitrotoluenes (DNT's)
by Liver, Lung, Intestine of A/J Mice and Fischer 344 Rats. Pharmacologist, 26, 204.
33.
Shulok, J.R., Klaunig, J.E., Selman, S.H., Schafer, P., Goldblatt, P.J. (1984). Ultrastructural Effects of
Combined Hematoporphyrin Derivative (HpD) and Phototherapy on Bladder Transitional Cell Carcinoma.
Proceedings of the 42nd Annual Meeting of the Electron Microscopy Society of America, 60-61.
34.
Selman, S.H., Britton, S.L., Keck, R., Klaunig, J.E., Kreimer-Birnbaum, M., Goldblatt, P.J. (1984). Acute
Blood Flow Changes in Transplantable Fanft-Induced Urothelial Tumors Treated with Hematoporphyrin
Derivative and Light. Toledo Surgical Society Annual Meeting.
35.
Pereira, M.A., Herren-Freund, S.L., Klaunig, J.E., Ruch, R.J. (1985). Tumor Promotion by Phenobarbital in
Mouse Liver. The Toxicologist, 5(1), 13.
36.
Chang, L.W., Pereira, M.A., Klaunig, J.E., Ruch, R.J. (1985). Effects of Hepatotoxins on Mouse and Rat
Hepatocytes from Preneoplastic/Neoplastic Lesions and from Partial Hepatectomized Animals. The
Toxicologist, 5(1), 150.
37.
Lucas D.M., Ruch, R.J., Teel, R., Klaunig, J.E. (1985). Benzo (a) Pyrene Metabolism and DNA Binding in
Teleost Skin and Liver Culture. The Toxicologist, 5(1), 15.
38.
Klaunig, J.E., Ruch, R.J., Pereira, M.A. (1985). Effects Of 1,1 Dichloroethane (1,1 DCE), 1,2
Dichloroethane (1,2 DCE) and Chloroform (CHCl3) in Drinking Water on Lung and Liver Tumor Incidence in
Mice. The Toxicologist, 5(1), 14.
39.
Selman, S.H., Klaunig, J.E., Barut, B.A., Keck, R.W. (1985). Characterization of the Metastatic Pattern of
the Transplantable Murine Bladder MBT-2 Tumor Line. American Urological Association 1985 Annual
Meeting, Atlanta, Georgia.
40.
Selman, S.H., Goldblatt, P.J., Klaunig, J.E., Keck, R.W., Kreimer-Birnbaum, M. (1985). Localization of
Hematoporphyrin Derivative (HpD) in Injured Bladder Mucosa. An Experimental Study. American
Urological Association 1985 Annual Meeting, Atlanta, Georgia.
41.
Shulok, J.R., Klaunig, J.E., Selman, S.H., Schut, H.A.J., Goldblatt, P.J. (1985). Cellular Effects of
Hematoporphyrin Derivative (HpD). American Association for Cancer Research Proceedings, 26, 1471.
42.
Milefchik, E.N., Askari, A., Birkhahn, R.H., Loeser, B.K., Klaunig, J.E. (1985). Superoxide Dismutase,
Catalase, Copper and Zinc In Murine Hepatocellular Carcinoma. Federation of the American Societies for
Experimental Biology Proceedings.
43.
Selman, S.H., Goldblatt, P.J., Klaunig, J.E., Keck, R.W., Kreimer-Birnbaum, M. (1985). Localization of
Hematoporphyrin Derivative (HpD) in Injured Bladder Mucosa. American Urological Association
Conference on Porphyrins as Phototherapeutic Agents for Tumors and Other Diseases, Alghero, Italy.
26
44.
Schultz, N.E., Ruch, R.J., Pereira, M.A., Lacher, D.A., Klaunig, J.E. (1985). Effects of Skf-525a, Vitamin E,
DPPD, and Diethylmaleate on Chloroform Toxicity to Isolated B6C3F1 Mouse Hepatocytes. Second
International Symposium on Health Effects of Drinking Water, Disinfectants and Disinfection By-Products,
Cincinnati, Ohio.
45.
Klaunig, J.E. (1985). Carcinogenicity of By-Products of Drinking Water Disinfection. Second International
Symposium on Health Effects of Drinking Water, Disinfectants and Disinfection By-Products, Cincinnati,
Ohio.
46.
Schut, H.A., Klaunig, J.E. (1986). Biochemical Parameters Associated with Initiation and Promotion of
Liver Carcinogenesis in Mice. The Toxicologist, 6(1), 231.
47.
Ruch, R.J., Klaunig, J.E., Pereira, M.A. (1986). Inhibition of Intercellular Communication Between Primary
Cultured Mouse Hepatocytes by Liver Tumor Promoters. The Toxicologist, 6(1), 232.
48.
Klaunig, J.E., Ruch, R.J., Pereira, M.A. (1986). Liver Tumor Promotion by Phenobarbital in Mice. The
Toxicologist, 6(1), 232.
49.
Deangelo, A.B., Herren-Freund, S., Pereira, M.A., Schultz, N.E., Klaunig, J.E. (1986). Species Sensitivity to
the Induction of Peroxisome Proliferation by Trichloroethylene and its Metabolites. The Toxicologist, 6(1),
113.
50.
Barut, B.A., Klaunig, J.E. (1986). Influence of Transplantation Site on Metastatic Ability of Mouse Bladder
Carcinoma Sublines. American Association for Cancer Research Proceedings, 27, 59.
51.
Shulok, J.R., Klaunig, J.E., Schut, H.A.J., Goldblatt, P.J. (1986). Uptake and Subcellular Effects of
Hematoporphyrin Derivative (HpD) in Normal and Neoplastic Rat Bladder Cells. American Association for
Cancer Research Proceedings, 27, 307.
52.
Askari, A., Klaunig, J.E., Thomford, N.R., Birkhahn, R.H. (1986). Zinc (Zn), Copper (Cu), Nitrogen (N),
Balances of Traumatized Rats Supported by Monoacetoacetin (MAA) or Glucose (G) Infusions. Federation of
the American Societies for Experimental Biology Proceedings, 45(4), 598.
53.
Ruch, R.J., Klaunig, J.E. (1986). Tumor Promoter Inhibition of Mouse Hepatocyte Intercellular
Communication. 37th Annual Meeting of the Tissue Culture Association, Chicago, Illinois.
54.
Barut, B.A., Klaunig, J.E. (1986). The In Vitro Sensitivity of A Murine Metastatic Transitional Cell
Carcinoma to Chemotherapeutic Agents. 37th Annual Meeting of the Tissue Culture Association, Chicago,
Illinois.
55.
Pereira, M.A., Klaunig, J.E., Herren-Freund, S.L., Ruch, R.J. (1986). The Effect of Phenobarbital on the
Development of Liver Tumors in Mice of Different Strains. American Association for Cancer Research
Proceedings, 27, 139.
56.
Barut, B.A., Klaunig, J.E. (1986). Correlative In Vivo/In Vitro Effects of Chemotherapeutic Agents on
Metastatic Mouse Bladder Cells. Midwest Tissue Culture Association Annual Meeting, Chicago, Illinois.
57.
Klaunig, J.E., Ruch, R.J. (1986). Inhibition of Intercellular Communication in Mouse Hepatocytes by Tumor
Promoters. American Society of Pharmacology and Experimental Therapeutics, Fall Meeting, Baltimore,
Maryland.
58.
Nigrovic, V., Klaunig, J.E., Smith, S., Schultz, N.E. (1986). Atracurium Induced Leakage of Lactic
Dehydrogenase (LDH) in Rat Hepatocytes. American Society of Pharmacology and Experimental
Therapeutics, Fall Meeting, Baltimore, Maryland.
27
59.
Awad, S., Birkhahn, R.H., Thomford, N.R., Klaunig, J.E. (1986). Hepatic Regeneration During Feeding with
Glucose Or Ketone Bodies with or without Amino Acids. American College of Nutrition, 27th Annual
Meeting, Washington, D.C.
60.
Askari, A., Cardwell, R.J., Crist, K.A, Klaunig, J.E., Brown, S., Thomford, N.R., Birkhahn, R.H. (1986).
Urinary Losses of Traumatized Septic Rats Supported by Monoacetoacetin or Glucose. American College of
Nutrition, 27th Annual Meeting, Washington, D.C.
61.
Baird, W.M., Smolarek, T.A., Pakuwov, II., Hevezi, K., Kelley, J., Klaunig, J.E. (1986). Formation of
Benzo(A)Pyrene 7,8 Dihydrodiol Glucuronide is a Major Pathway of Metabolism of Benzo(A)Pyrene in Cell
Cultures from Bluegill Fry and Brown Bullhead. Symposium on Toxic Chemicals and Aquatic Life, Seattle,
Washington.
62.
Grekinis, D., Wojta, D.M., Klaunig, J.E., Andres, F.F. (1986). Exercise as a Prophylactic Agent for
Inflammatory Induced Diabetes Mellitus. International Meeting of Exercise and Biochemistry, Athens,
Greece.
63.
Ruch, R.J., Klaunig, J.E. (1986). Antioxidants, Caffeine and Dibutyl cAMP Prevent the Inhibition of Mouse
Hepatocyte Intercellular Communication by Liver Tumor Promoters. 16th Conference on Toxicology,
Dayton, Ohio.
64.
Weghorst, C.M., Pereira, M.A., Klaunig, J.E. (1986). Influence of the Time of Phenobarbital Treatment on
Liver Tumor Development in Initiated B6C3F1 Mice. 16th Conference on Toxicology, Dayton, Ohio.
65.
Schafer, P.J., Klaunig, J.E., Hampton, J.A., Crist, K.A. (1986). Induction of Peroxisome Proliferation In
Male B6C3F1 Mice Following Chronic Exposure to High Fat Diets. Eleventh Symposium of the
Northwestern Ohio Electron Microscopy Society, Bowling Green State University.
66.
Hampton, J.A., Klaunig, J.E., Goldblatt, P.J. (1986). Resident Sinusoidal Macrophages in the Brown
Bullhead (Ictalurus Nebulosus) Liver. Eleventh Symposium of the Northwestern Ohio Electron Microscopy
Society, Bowling Green State University.
67.
Klaunig, J.E., Schultz, N.E., Crist, K.A. (1987). Hepatic Tumor Promotion by Dietary Fat in B6C3f1 Male
Mice. The Toxicologist, 7(1), 103.
68.
Ruch, R.J., Klaunig, J.E. (1987). Antioxidants and Cyclic Amp Agonists Prevent the Inhibition of Mouse
Hepatocyte Intercellular Communication by Liver Tumor Promoters. The Toxicologist, 7(1), 130.
69.
Weghorst, C.M., Klaunig, J.E., Pereira, M.A. (1987). Effects of the Time of Onset of Phenobarbital (Pb)
Administration on Hepatic Tumor Expression in Diethylnitrosamine (DENA) Initiated B6C3F1 Mice. The
Toxicologist, 7(1), 103.
70.
Schafer, P.J., Klaunig, J.E., Hampton, J.A. (1987). Induction of Hepatic Peroxisome Proliferation in Male
B6C3F1 Mice Following High Fat Dietary Exposure. The Toxicologist, 7(1), 164.
71.
Hampton, J.A., Klaunig, J.E. (1987). Hepatotoxicity of Acetaminophen in the Brown Bullhead Catfish
(Ictalurus Nebulosus). The Toxicologist, 7(1), 151.
72.
Crist, K.A., Schultz, N.E., Klaunig, J.E. (1987). Effect of Dietary Fat and Vitamin A Restriction on
Metastasis in Mice. Federation of the American Society of Experimental Biology Proceedings.
73.
Ruch, R.J., Klaunig, J.E. (1987). Kinetics of the Inhibition of Mouse Hepatocyte Intercellular
Communication by the Liver Tumor Promoter Phenobarbital. Great Lakes Regional Meeting of the Society of
Toxicologic Pathologists, Cincinnati, Ohio.
28
74.
Nigrovic P.A., Ruch, R.J., Loeser, B., Klaunig, J.E. (1987). Effects of Culture Age on Hydrogen Peroxide
Cytotoxicity and Antioxidant Enzyme Activities in Primary Cultured Mouse Hepatocytes. Great Lakes
Regional Meeting of the Society of Toxicologic Pathologists, Cincinnati, Ohio.
75.
Weghorst, C.M., Klaunig, J.E., Pereira, M.A. (1987). Effects of the Initiating Carcinogen on the Promoting
Ability of Phenobarbital in the Infant B6C3F1 Male Mouse. Great Lakes Regional Meeting of the Society of
Toxicologic Pathologists, Cincinnati, Ohio.
76.
Schultz, N.E., Klaunig, J.E. (1987). Influence of High Fat Diets on Chemically Induced Hepatic
Tumorigenesis in the B6C3F1 Male Mouse. Great Lakes Regional Meeting of The Society of Toxicologic
Pathologists, Cincinnati, Ohio.
77.
Ruch, R.J., Klaunig, J.E. (1987). Kinetics of the Inhibition of Mouse Hepatocyte Intercellular
Communication by the Liver Tumor Promoter Phenobarbital. 17th Conference of Toxicology, Dayton, Ohio.
78.
Weghorst, C.M., Klaunig, J.E. (1987). Comparative Effects of Phenobarbital, Sodium Barbituric,
Amobarbital, and Barbituric Acid on Intercellular Communication in Cultured Rat Hepatocytes. 17th
Conference of Toxicology, Dayton, Ohio.
79.
Schultz, N.E., Klaunig, J.E. (1987). Hepatic Tumor Promotion by High Fat Diets in the B6C3F1 Male
Mouse. 17th Conference of Toxicology, Dayton, Ohio.
80.
Lilly, S.G., Klaunig, J.E. (1987). Intercellular Communication in Male Wistar Rat Hepatocytes Induced by
the Solt-Farber Resistance Hepatocyte Model. 17th Conference of Toxicology, Dayton, Ohio.
81.
Goldblatt, P.J., Schafer, L.D., Hampton, J.A., Klaunig, J.E., Bearss, D.J., Schut, H.A.J. (1987). Regeneration
and Transformation. Third International Symposium on Cellular Endocrinology, Lake Placid, New York.
82.
Ruch, R.J., Klaunig, J.E. (1988). Kinetics of the Inhibition of Mouse Hepatocyte Intercellular
Communication by the Liver Tumor Promoter Phenobarbital. The Toxicologist, 8(1), 168.
83.
Nigrovic, P.A., Ruch, R.J., Klaunig, J.E. (1988). Inhibition of Mouse Hepatocyte Intercellular
Communication by Activated Oxygen. The Toxicologist, 8(1), 167.
84.
Lilly, S.G., Klaunig, J.E. (1988). Inhibition of Intercellular Communication in Preneoplastic Rat Hepatocytes
Induced by the Solt-Farber Model. The Toxicologist, 8(1), 194.
85.
Klaunig, J.E., Weghorst, C.M., Pereira, M.A., Lin, E., Weghorst, T.R. (1988). Phenobarbital Promotion in
Infant B6C3F1 Mice: Influence of Gender and Initiator. The Toxicologist, 8(1), 168.
86.
Hampton, J.A., Goldblatt, P.J., Klaunig, J.E. (1988). Diethylnitrosamine Induced Hepatic Carcinogenesis in
the Brown Bullhead (Ictalurus Nebulosus) Catfish. The Toxicologist, 8(1), 168.
87.
Schultz, N.E., Ruch, R.J., Klaunig, J.E. (1988). Mechanism of Inhibition of Intercellular Communication by
the Promoters DDT, Phenobarbital, and Lindane in Male B6C3F1 Mouse Hepatocytes. The Toxicologist,
8(1), 168.
88.
Smolarek, T.A., Baird, W.M., Morgan, S., Ferin, M., Nishimoto, M., Stein, J.E., Varanasi, U., Klaunig, J.E.
(1988). Metabolic Activation of Benzo (A) Pyrene (BAP) to DNA-Binding Metabolites in Primary Hepatocyte
Cultures Fish. American Association for Cancer Research Proceedings.
89.
Bandyopadhyay, S., Klaunig, J.E., Gross, S.A., Somani, P. (1988). Amiodarone (AM) and
Desethylamiodarone (Da) Induced Multilamellar Inclusion Bodies in Rat Hepatocytes in Culture. Annual
Meeting of the American Heart Association.
29
90.
Weghorst, C.M., Klaunig, J.E. (1988). The Role of Barbiturate Metabolism in the Inhibition of Intercellular
Communication Between Cultured Hepatocytes. The Toxicologist, 8(1), 194.
91.
Ruch, R.J., Hampton, J.A., Klaunig, J.E. (1988). Loss of Gap Junctional Intercellular Communication in
Rodent Hepatocytes Cultured in Rpmi 1640 Medium but not in Leibovitz's L-15 or William's E Media.
Toxicological Implications of Altered Gap Junctional Intercellular Communication, East Lansing, Michigan.
92.
Lilly, S.G., Ruch, R.J., Schultz, N.E., Holbrook, T., Klaunig, J.E. (1988). Kinetics of Inhibition of
Intercellular Communication by Tumor Promoters in Mouse Hepatocytes. Toxicological Implications of
Altered Gap Junctional Intercellular Communication, East Lansing, Michigan.
93.
Schultz, N.E., Gray, T.J.B., Klaunig, J.E. (1988). Inhibition of Intercellular Communication in Cultured Rat
Hepatocytes by the Peroxisome Proliferator Nafenopin. Toxicological Implications of Altered Gap Junctional
Intercellular Communication, East Lansing, Michigan.
94.
Weghorst, C.M., Ruch, R.J., Klaunig, J.E. (1988). Effects Of Barbiturates on the Inhibition of Intercellular
Communication in Primary Rat and Mouse Hepatocyte Cultures. Toxicological Implications of Altered Gap
Junctional Intercellular Communication, East Lansing, Michigan.
95.
Hampton, J.A., Holbrook, T., Weghorst, C.M., Klaunig, J.E. (1988). Effects of Phenobarbital on Isolated
Enriched Populations of Periportal and Pericentral Mouse Hepatocytes. Toxicological Implications of Altered
Gap Junctional Intercellular Communication, East Lansing, Michigan.
96.
Xie, A., Askari, A., Klaunig, J.E (1988). Intercellular Communication in Cultured Neonatal Rat Ventricle
Cells. Toxicological Implications of Altered Gap Junctional Intercellular Communication, East Lansing,
Michigan.
97.
Defeyter, E., Weghorst, C.M., Ruch, R., Klaunig, J.E., Change, C.C., Madhukar, B.V., El-Fouly, M., Trosko,
J.E. (1988). Reduced Gap Junctional Intercellular Communication and Tumorigenicity of Rat Liver Epithelial
("Oval”, F344-WB) Cells. Toxicological Implication of Altered Gap Junctional Intercellular Communication,
Michigan State University, East Lansing, Michigan.
98.
Hall, S.K., Klaunig, J.E., Markiewicz, D.S., Sherman, L.D. (1988). Quantitative Risk Assessment for
Occupational Health. International Conference on Ergonomics, Occupational Safety and Health, and the
Environment, Beijing, China.
99.
Somani, P., Bandyopadhyay, S., Klaunig, J.E. (1988). Effect of Verapamil, Amidarone, and
Desethylamidarone on Lactate Dehydrogenase (Ldh) Release and Intracellular Inclusions in Isolated Rat
Hepatocytes. American Society of Pharmacology and Experimental Therapeutics, Montreal, Canada.
100.
Weghorst, C.M., Klaunig, J.E. (1988). Effect of Phenobarbital on DENA-Initiated Liver Tumors in Male and
Female B6C3F1 Mice. 18th Conference on Toxicology, Dayton, Ohio.
101.
Ruch, R.J., Weghorst, C.M., Klaunig, J.E. (1988). Correlation Between In Vivo Liver Carcinogenicity and In
Vitro Inhibition of Hepatocyte Intercellular Communication by Nongenotoxic Carcinogens. 18 th Conference
on Toxicology, Dayton, Ohio.
102.
Weghorst, T.R., Klaunig, J.E., Weghorst, C.M. (1988). Effects of Corn Oil Gavage on Hepatic Tumor
Formation in the B6C3F1 Male Mouse. 18th Conference on Toxicology, Dayton, Ohio.
103.
Fry, K.L., Weghorst, C.M., Klaunig, J.E. (1988). Comparative Hepatocyte Proliferation Response in the
Mouse and Rat Following Acute Treatment with Trichloroethylene and Phenobarbital. 18 th Conference on
Toxicology, Dayton, Ohio.
104.
Lilly, S.G., Weghorst, C.M., Klaunig, J.E. (1988). Failure of the "Solt-Farber Protocol" to Induce
Preneoplastic or Neoplastic Changes in the B6C3F1 Mouse. 18 th Conference on Toxicology, Dayton, Ohio.
30
105.
Klaunig, J.E., Weghorst, C.M. (1988). Dissimilar Patterns of Hepatic Tumor Promotion by Phenobarbital in
Neonatally Initiated B6C3F1, C3H, and C57/Bl Male Mice. 18 th Conference on Toxicology, Dayton, Ohio.
106.
Schultz, N.E., Gray, T.J.B., Klaunig, J.E. (1988). Effects of the Peroxisome Proliferator Nafenopin on
Intercellular Communication in Cultured Rat Hepatocytes. 18 th Conference on Toxicology, Dayton, Ohio.
107.
Ruch, R.J., Klaunig, J.E. (1988). Inhibition of Mouse Hepatocyte Gap Junctional Intercellular
Communication by Oxygen Free Radicals. Mouse Liver Carcinogenesis Conference, Mechanisms and
Species Comparisons, Austin, Texas.
108.
Klaunig, J.E. (1988). Role of Inhibition of Gap Junction Mediated Intercellular Communication In Hepatic
Carcinogenesis. Mouse Liver Carcinogenesis Conference, Mechanisms And Species Comparisons, Austin,
Texas.
109.
Weghorst, C.M., Klaunig, J.E. (1988). Dissimilar Patterns of Phenobarbital Mediated Hepatic Tumor
Promotion In 15 Day Old Initiated Mice. Mouse Liver Carcinogenesis Conference, Mechanisms and Species
Comparisons, Austin, Texas.
110.
Wojta, D.M., Andres, F.F., Grekinis, D., Klaunig, J.E. (1989). The Effect of Exercise Training On Pancreatic
Islet Morphology. American College of Sports Medicine Annual Meeting, St. Louis, Missouri.
111.
Trosko, J., Chang, C.C., Klaunig, J.E. (1989). Role of Inhibition of Gap Junction Mediated Intercellular
Communication on Hepatic Carcinogenesis. Molecular Cell Biology of Gap Junctions, Irsee, Germany.
112.
Schut, H.A.J., Weghorst, C.M., Klaunig, J.E., Zu, H.Z. (1989). Dynamics of DNA Adduct Formation of 2Amino-3-Methylimidazo [4, 5-F] Quinoline in Newborn CDF1 Mice and Identification of the Major Adduct.
80th Annual Meeting of American Association for Cancer Research, San Francisco, California.
113.
Ruch, R.J., Cheng, Shu-Jun, Klaunig, J.E. (1989). Prevention of Cytotoxicity and Inhibition of Intercellular
Communication by Antioxidant Chinese Green Tea Catechins. The Ninth Annual Meeting of the Michigan
Regional Chapter of The Society of Toxicology, Ann Arbor, Michigan.
114.
Hartnett, J.A., Hampton, J.A., Klaunig, J.E. (1989). Inhibition of Gap Junctional Intercellular
Communication by Tumor Promoters in the Rodent Liver. The Ninth Annual Meeting of the Michigan
Regional Chapter of The Society of Toxicology, Ann Arbor, Michigan.
115.
Weghorst, C.M., Ruch, R.J., Klaunig, J.E. (1989). Barbiturate Mediated Inhibition of Intercellular
Communication in Primary Mouse and Rat Hepatocyte Cultures. The Ninth Annual Meeting of the Michigan
Regional Chapter of The Society of Toxicology, Ann Arbor, Michigan.
116.
Xie, Z., Klaunig, J.E., Askari, A. (1989). Effects of Fatty Acids on the Junctional Communication Between
Myocytes. The Ninth Annual Meeting of the Michigan Regional Chapter of The Society of Toxicology, Ann
Arbor, Michigan.
117.
Hampton, J.A., Weghorst, C.M., Ruch, R.J., Klaunig, J.E. (1989). Intercellular Communication and Rodent
Hepatocyte Heterogeneity. The Toxicologist, 9(1), 121.
118.
Ruch, R.J., Hampton, J.A., Klaunig, J.E. (1989). Effects of Culture Medium n Hepatocyte Gap Junctional
Intercellular Communication. The Toxicologist, 9(1), 122.
119.
Schultz, N.E., Gray, T.J.B., Klaunig, J.E. (1989). Inhibition of Intercellular Communication in Cultured Rat
Hepatocytes by Induction of Peroxisome Proliferation. The Toxicologist, 9(1), 122.
120.
Hartnett, J.A., Ruch, R.J., Weghorst, C.M., Klaunig, J.E. (1989). Correlation Between Hepatic
Carcinogenicity and Inhibition of Hepatocyte Intercellular Communication by Non-Genotoxic Carcinogens.
The Toxicologist, 9(1), 122.
31
121.
Klaunig, J.E., Ruch, R.J., Lilly, S.G., Weghorst, C.M. (1989). Role of Inhibition of Hepatocyte Intercellular
Communication in Tumor Promotion. The Toxicologist, 9(1), 123.
122.
Lilly, S.G., Defeyter, E., Weghorst, C.M., Chang, C.C., Madhukar, B.V., El-Fouly, M., Trosko, J.E., Klaunig,
J.E. (1989). Reduced Gap Junctional Intercellular Communication of Rat Liver Epithelial ("Oval", F344-Wb)
Cells. The Toxicologist, 9(1), 122.
123.
Khoury, M.M., Barnwell, P.L., Wasmund, K.K., Klaunig, J.E., Pereira, M.A. (1989). Initiation-Promotion
Bioassay in Mouse Liver. The Toxicologist, 9(1), 123.
124.
Weghorst, C.M., Klaunig, J.E. (1989). Strain and Gender Dependent Patterns of Hepatic Tumor Promotion
in Neonatally Initiated Mice to Phenobarbital. The Toxicologist, 9(1), 129.
125.
Siglin, J.C., Weghorst, C.M., Rodwell, D.E., Klaunig, J.E. (1989). Inhibition of Liver Tumor Formation by
Alpha-Hexachlorocyclohexane (a-HCH) In Diethylnitrosamine (DENA) Initiated B6C3F1 Mice. The
Toxicologist, 9(1), 214.
126.
Fry, K.L., Weghorst, C.M., Klaunig, J.E. (1989). Hepatocyte Proliferation in the Mouse and Rat Following
Acute Treatment with Trichloroethylene. The Toxicologist, 9(1), 214.
127.
Siglin, J.C., Weghorst, C.M., Klaunig, J.E. (1989). Correlation of Cell Proliferation Rates in Mouse
Hepatocellular Lesions with Tumor Promoting Ability of Phenobarbital and Alpha-Hexachlorocyclohexane.
Chemically Induced Cell Proliferation, Implications for Risk Assessment, Austin, Texas.
128.
Hampton, J.A., Weghorst, C.M., Siglin, J.C., Schafer, L.D., Klaunig, J.E. (1989). Effect Correlation Between
Species and Strain Susceptibility to Chemical Carcinogens and Induction of DNA Synthesis. Chemically
Induced Cell Proliferation, Implications for Risk Assessment, Austin, Texas.
129.
Trosko, J.E., Klaunig, J.E., Madhukar, B.V., Chang, C.C., De Feijter, E., Kalimi G. (1989). Chemical and
Oncogene Modulation Of Intercellular Communication During Carcinogenesis. Molecular Endocrinology of
the Liver Conference, Lake Placid, New York.
130.
Bandyopadhyay, S., Klaunig, J.E., Somani, P. (1990). Effect of Lovastatin on Cell-To-Cell Communication
in Hepatocytes in Tissue Culture. 91st Annual Meeting of American Society for Clinical Pharmacology and
Therapeutics, San Francisco, California.
131.
Ruch, R.J., Trosko, J.E., Madhukar, B.V., Somani, P., Klaunig, J.E. (1990). Restoration of Gap Junctional
Intercellular Communication by Lovastatin in WB-H-RasIIa Rat Liver Epithelial Cells. The Toxicologist,
10(1).
132.
Weghorst, C.M., Hampton, J.A., Klaunig, J.E. (1990). Effects of Barbiturate Compounds on Hepatic and
Renal Cell Proliferation in the Rat. The Toxicologist, 10(1).
133.
Bandyopadhyay, S., Ruch, R.J., Somani, P., Klaunig, J.E. (1990). Inhibition of Rodent Hepatocyte Gap
Junctional Intercellular Communication (GJIC) By Lovastatin. The Toxicologist, 10(1).
134.
Schafer, P.J., Xie, Z., Askari, A., Klaunig, J.E. (1990). Inhibition of Gap Junctional Intercellular
Communication (GJIC) in Myocytes by Oxygen Free Radicals. The Toxicologist, 10(1).
135.
Xie, Z., Askari, A., Klaunig, J.E. (1990). Inhibition of Cardiac Gap Junctional Intercellular Communication
(GJIC) by Amphiphilic Compounds: Role of Extracellular pH. The Toxicologist, 10(1).
136.
Hartnett, J.A., Weghorst, C.M., Klaunig, J.E. (1990). In Vivo Inhibition of Gap Junctional Intercellular
Communication (GJIC) by Tumor Promoters in the Rat Liver. The Toxicologist, 10(1).
32
137.
Hampton, J.A., Klaunig, J.E. (1990). Inhibition of Gap Junctional Intercellular Communication (GJIC) By
Decreased Intracellular pH. The Toxicologist, 10(1).
138.
Schutrum, L.E., Hartnett, J.A., Resau, J.H., Didolkar, M.S., Cottrell, J.R., Klaunig, J.E. (1990). Gap
Junctional Intercellular Communication (GJIC) in Human Liver. The Toxicologist, 10(1).
139.
Schafer, L.D., Hartnett, J.A., Hampton, J.A., Weghorst, C.M., Olson, M.J., Klaunig, J.E. (1990). Induction of
Cell Proliferation in Rat and Mouse Hepatic and Renal Tissue Following Treatment with Gasoline. The
Toxicologist, 10(1).
140.
Trosko, J.E., Klaunig, J.E., Yaeger, M., Koestner, A., El-Fouly, M. Buboltz, J., Cool, B., Chang, C.C. (1990).
Correlation Between the Reduction of Gap Junctional Communication and Tumorigenesis in Rat Glial and
Liver Epithelial Cells Containing the Expressed Neu Oncogene. The Toxicologist, 10(1).
141.
Khoury, M.D., Wasmund, K.K., Hensley, M.S., Klaunig, J.E., Pereira, M.A. (1990). The Effect of Gender
and Phenobarbital Promotion upon the Sensitivity of Infant C3H Mice to Chemical Carcinogens. The
Toxicologist, 10(1).
142.
Askari, A., Wang, Y., Xie, A., Huang, W.H., Klaunig, J.E., Askari, A. (1990). Superoxide Dismutase
Activity of Copper Deficient Cardiac Myocytes. Federation of the American Society of Experimental Biology
Proceedings.
143.
Klaunig, J.E., Ruch, R.J., Hartnett, J.A., Schutrum, L.E. (1990). Gap Junctional Intercellular Communication
During Murine Hepatic Carcinogenesis. 81st Annual Meeting of the American Association for Cancer
Research, 31, 150.
144.
Askari, A., Wang, Y., Orlowski, E., Xie, J., Crist, K.A., Klaunig, J.E., Thomford, N.R., Birkhahn, R.H.
(1990). Urinary Mineral Losses of Cu Adequate (CuA) or Cu Deficient (CuD) Sprague-Dawley Rats. Ohio
Academy Of Science, Columbus, Ohio.
145.
Klaunig, J.E., Schutrum, L.E. (1990). Changes in Intercellular Communication as a Measure of Hepatocyte
Toxicity. Tissue Culture Association 41st Annual Meeting, Houston, Texas.
146.
Leboeuf, R.A., Ruch, R., Klaunig, J.E. (1990). Changes in Gap Junctional Intercellular Communication in
Syrian Hamster Embryo Cells by Changes in Extracellular. 81st Annual Meeting of the American Association
for Cancer Research, 31, 109.
147.
Nigrovic, V., Klaunig, J.E., Fry, K. (1990). Acrylate Metabolites of Atracurium as the Proximate Cytotoxic
Agent in Cultured Rat Hepatocytes. Anesthesia Analog., 70, S282.
148.
Ruch, R.J., Trosko, J.E., Klaunig, J.E. (1991). Growth Inhibition and Phenotypic Reversion of rasTransformed Rat Liver WB-F344 Cells by Mevinolin. American Association for Cancer Research
Proceedings, 32, 131.
149.
Cummings, D.A., Lin, E.L.C., Daniel, F.B., Klaunig, J.E., Schut, H.A.J. (1991). In Vivo and In Vitro
Binding of Benzo(A)Pyrene to Tissue DNA and Circulating Macromolecules in the Mouse, Monkey and
Human. American Association for Cancer Research Proceedings, 32, 159.
150.
Rush, R.E., Rodwell, D.E., Siglin, J.C., McKenzie, J.J., Mercieca, M.D., Klaunig, J.E. (1991). Induction of
Hepatocyte DNA Synthesis in Male B6C3F1 Mice Following Subchronic Exposure to 1, 1, 2Trichloroethylene (TCE). The Toxicologist, 11(1).
151.
Schafer, L.D., Klaunig, J.E. (1991). Concentration and Duration Dependent Induction of Hepatocyte DNA
Synthesis in Male B6C3F1 Mice Exposed to Phenobarbital (PB). The Toxicologist, 11(1).
33
152.
Cao, J., Schafer, L.D., Schutrum, L.E., Wilkinson, J.T., Klaunig, J.E. (1991). Selective Induction of DNA
Synthesis in Preneoplastic Foci in Male B6C3F1 Mice Exposed to Phenobarbital or Chloroform (CHCL3).
The Toxicologist, 11(1).
153.
Schutrum, L.E., Dupont, E., Cao, J., Xie, Z., Resau, J.H., Cottrell, J.R., Klaunig, J.E. (1991). Gap Junctional
Intercellular Communication (GJIC) and Gap Junctional (GJ) Protein Expression in Rodent and Human
Hepatocytes. The Toxicologist, 11(1).
154.
Wang, X., Cao, J., Dupont, E., Xie, Z., Trosko, J.E., Klaunig, J.E. (1991). Gap Junction Protein Expression
in Normal, Neoplastic Murine Liver. The Toxicologist, 11(1).
155.
Xie, Z., Askari, A., Klaunig, J.E. (1991). Regulation of Myocyte Gap Junctional Intercellular
Communication (GJIC) by Intracellular Calcium. The Toxicologist, 11 (1).
156.
Wilkinson, J.T., Olson, M.J., Klaunig, J.E. (1991). Effects of the Halogenated Compounds R-132A, R133A, R-134B, and Haolthane on Gap Junctional Intercellular Communication (GJIC) in Rodent Hepatocytes
and Myocytes. The Toxicologist, 11(1).
157.
Smith, A.F., Xie, Z., Kwiatkowski, A., Dupont, E., Trosko, J., Klaunig, J.E. (1992). Altered Expression of
Gap Junctions in Mouse Tumor. The Toxicologist, 12(1).
158.
Cao, J., Popp, J.A., Klaunig, J.E. (1992). Induction of Replicative DNA Synthesis in Cultured Mouse
Hepatocytes After Exposure to Nongenotoxic Carcinogens. The Toxicologist, 12(1).
159.
Steinmetz, K., Klaunig, J.E. (1992). Induction of Replicative DNA Synthesis (RDS) in Mouse Liver Lesions
after Exposure to Phenobarbital. The Toxicologist, 1(1).
160.
Schut, H.A.J., Cummings, D.A., Klaunig, J.E., Lin, E.L.C., Daniel, F.B. (1992). Dibenz [a, h] Anthracene
(DB [a, h] A)-DNA Adduct Formation in the Mouse In Vivo and in Mouse, Monkey and Human Liver Slices
In Vitro. The Toxicologist, 12 (1).
161.
Sargent, L.M., Haas, M.J., Babcock, K.L., Goodspeed, D., Klaunig, J.E. (1993). Specific Chromosomal
Changes and Expression of Insulin Growth Factor II (IGF II) and p53 in v-Ha-ras-infected Rat Liver Epithelial
Cells. American Association for Cancer Research Proceedings, 34, A766.
162.
Steinmetz, K., Kwiatkowski, A., Klaunig, J.E. (1993). Expression of Genes for Gap Junctional Proteins in
Liver Tumors from Mice Treated with Diethyl-Nitrosamine (DEN). The Toxicologist, 13, 136.
163.
Kwiatkowski, A., Cao, J., Klaunig, J.E. (1993). Effects of Subchronic Administration of Phenobarbital on
the Expression of Metallothionein in the Livers of C3H, C57BL Mice. The Toxicologist, 13, 294.
164.
Cao, J., Kwiatkowski, A., McKenzie, J., Klaunig, J.E. (1993). Effects of Subchronic Administration of
Phenobarbital on mRNA Levels of Gap Junction Proteins in C3H and C57BL Mouse Liver. The Toxicologist,
13, 354.
165.
Baker, T., Kwiatkowski, A., Stevenson, D., Walborg, E., Klaunig, J.E. (1993). Effects of Organochlorine
Pesticides on Gap Junctional Intercellular Communication (GJIC) in Rodent and Primate Hepatocytes. The
Toxicologist, 13, 354.
166.
Bachowski, S., Baker, T., Stevenson, D., Walborg, E., Klaunig, J.E. (1993). Cellular Effects of Dieldrin in
F344 Rat and B6C3F1 Mouse Hepatocytes. Growth Factors and Tumor Promotion: Implications for Risk
Assessment Conference, Barton Creek, Texas.
167.
Baker, T., Bachowski, S., Stevenson, D., Walborg, E., Klaunig, J.E. (1993). Modulation of Gap Junctional
Intercellular Communication in Rodent, Monkey and Human Hepatocytes by Organochlorine Pesticides.
Growth Factors and Tumor Promotion: Implications for Risk Assessment Conference, Barton Creek, Texas.
34
168.
Kolaja, K., Walborg, E., Stevenson, D., Klaunig, J.E. (1993). Effect of Dieldrin on Preneoplastic and
Neoplastic Hepatic Lesions Induced in B6CF1 Mice and F344 Rats by Diethylnitrosamine. Growth Factors
and Tumor Promotion: Implications for Risk Assessment Conference, Barton Creek, Texas.
169.
Stevenson, D., Johnson, J., Walborg, E., Klaunig, J.E. (1993). Subchronic Exposure of B6C3F1 Mice and
F344 Rats to Dieldrin and Phenobarbital: Induction of Hepatic DNA Synthesis. Growth Factors and Tumor
Promotion: Implications for Risk Assessment Conference, Barton Creek, Texas.
170.
Stevenson, D., Kehrer, J., Kolaja, K., Walborg, E., Klaunig, J.E. (1993). Modulation of Dieldrin-Induced
Hepatic Effects in B6C3F1 Mice by Dietary Antioxidants. Growth Factors and Tumor Promotion:
Implications for Risk Assessment Conference, Barton Creek, Texas.
171.
Xu, Y., Cao, J., Stevenson, D., Walborg, E., Klaunig, J.E. (1993). Use of 8-Hydroxy-2'-Deoxyguanosine to
Measure Oxidative Damage to Hepatic DNA in Mice and Rats: Correlations with Incidence of "Spontaneous"
and Dieldrin-Induced Hepatocarcinogenesis. Growth Factors and Tumor Promotion: Implications for Risk
Assessment Conference, Barton Creek, Texas.
172.
Dean, R., Cummings, O., Stone, C., Klaunig, J.E. (1994). Comparison of Cocaine (C) and Cocaethylene
(CE) - Induced Liver Injury in Mouse. The Toxicologist, 14.
173.
Sargent, L.M., Dragan, Y.P., Babcock, K., Wiley, JO, Haas, M.J., Klaunig, J.E., Satire, G., Satire, C., Pitot,
H.C. (1994). Specific Chromosomal Changes in Alb-SV-40 Transgenic Rat Liver Neoplasms and Neoplasms
Derived from Ha-ras Transformed Liver Epithelial Cells. American Association for Cancer Research
Proceedings, 35, A974.
174.
Schafer, L.D., Klaunig, J.E. (1994). Dose and Time Dependent Effects of Phenobarbital (PB) on Hepatic
Cell Proliferation of Male B6C3F1 Mice. Ohio Journal of Science, 94(2), 15.
175.
Xu, Y., Bachowski, S., Stevenson, D.E., Walborg, E.F. Jr., Klaunig, J.E. (1994). A Relationship between
Oxidative Stress and Species Susceptibility to Hepatocarcinogenesis Induced by Dieldrin and Phenobarbital in
B6C3F1 Mice and F344 Rats. Pennsylvania State University 13th Summer Symposium in Molecular Biology.
176.
Nie, Y., Bachowski, S., Knoblach, S.M., Schoepp, D.D., Klaunig, J.E., Kubek, M.J. (1995). Potassium
Induced Changes in Thyrotropin-Releasing Hormone (TRH), Glutamate, Lactate Dehydrogenase Release from
Hippocampal Slices after Seizure. The Endocrine Society Symposium.
177.
Bachowski, S., Xu, Y., Stevenson, D.E., Walborg, E.F. Jr., Klaunig, J.E. (1995). Role of Oxidative Stress in
Dieldrin Induced Mouse Hepatocarcinogenesis. The Toxicologist, 15(1), 200.
178.
Xu, Y., Bachowski, S., Stevenson, D.E., Walborg, E.F. Jr., Klaunig, J.E. (1995). Correlation Between the
Induction of Oxidative Stress and Rodent Susceptibility to Hepatocarcinogenesis. The Toxicologist, 15(1),
200-201.
179.
Ketcham, C.A., Bachowski, S., Stevenson, D.E., Walborg, E.F. Jr., Kolaja, K.L., Klaunig, J.E. (1995). Effect
of Vitamin E on Dieldrin Induced Hepatic DNA Synthesis and Neoplasia in Mice. The Toxicologist, 15(1),
216.
180.
Kolaja, K.L., Stevenson, D.E., Walborg, E.F. Jr., Carfagna, M.A., Klaunig, J.E. (1995). Comparative Effects
of Dieldrin and Phenobarbital upon Hepatic Preneoplastic and Neoplastic Lesion DNA Synthesis and Tumor
Promotion in B6C3F1 Mice and F344 Rats. The Toxicologist, 15 (1), 200.
181.
Carfagna, M.A., Kolaja, K.L., Johnson, J.T., Stevenson, D.E., Walborg, E.F. Jr., Klaunig, J.E. (1995).
Selective Induction of DNA Synthesis by Dieldrin in Mouse Liver. The Toxicologist, 15(1), 200.
35
182.
Baker, T.K., Kwiatkowski, A.P., Madhukar, B.V., Klaunig, J.E. (1995). Modulation of Rat Hepatocytes Gap
Junctional Intercellular Communication by 2, 3, 7, 8-Tetrachlorodibenzo-[P]-Dioxin (TCDD). The
Toxicologist, 15(1), 67.
183.
Madhukar, B.V., Little, R.A., Klaunig, J.E., Trosko, J.E. (1995). Activation of Protein Kinase C Alpha
(PKCunication by Polychlorinated Biphenyls (PCB) in Rat Liver
Epithelial Cells. The Toxicologist, 15(1), 28.
184.
Steinmetz, K.L., Klaunig, J.E.
F344 Rats Early Hepatic Foci. The Toxicologist, 15(1), 229.
185.
Klaunig, J.E., Xu, Y., Bachowski, S., Ketcham, C.A., Isenberg, J.S., Baker, T.K., Walborg, E.F. Jr.,
Stevenson, D.E. (1995). Oxidative Stress in Nongenotoxic Carcinogenesis. International Congress of
Toxicology, Seattle, Washington.
186.
Xu, Y., Bachowski, S., Klaunig, J.E. (1995). Association between Induction of Oxidative Stress and Rodent
Strain and Species Susceptibility to Hepatocarcinogenesis. International Congress of Toxicology VII, Seattle,
Washington.
187.
Baker, T.K., Xu, Y., Isenberg, J.S., Chen, W.L. Chen, Gibson, J.E., Bus, J.S., Klaunig, J.E. (1995).
Fenazaquin Toxicity in Rat Mouse Hamster and Human Cells. International Congress of Toxicology VII,
Seattle, Washington.
188.
Kalimi, G.H., Lington, A.W., Nikiforov, A.I., Klaunig, J.E. (1995). Gap Junction Assay in Rodent
Hepatocytes: A Good Predictor for Liver Cancer in Rodents for Phthalate Esters. The Toxicologist, 15(1),
274.
189.
Ketcham, C.A., Klaunig, J.E. (1996). Effect of Protein Kinase C Inhibitors on Hepatic Gap Junctional
Intercellular Communication Blockage by Peroxisome Proliferators. The Toxicologist, 30(1), 206.
190.
Baker, T.K., Kalimi, G.H., Lington, A.W., Isenberg, J.S., Klaunig, J.E., Nikiforov, A.I. (1996). Gap
Junctional Intercellular Communication Studies on 5 Phthalate Monoesters in Hepatocytes of Four Species:
Implications for Cancer Risk Assessment. The Toxicologist, 3 (1), 208.
191.
Isenberg, J.S., Baker, T.K., Kalimi, G.H., Lington, A.W., Klaunig, J.E., Nikiforov, A.I. (1996). Gap
Junctional Intercellular Communication Studies on Mono-2-Ethylhexyl Phthalate (MEHP) in Rat Hepatocytes:
Effects of Modulators on Oxidative Stress, Signal Transduction, Peroxisomal Beta Oxidation (PBOX) and P
450 Pathways. The Toxicologist, 30(1), 208.
192.
Lington, A.W., Kalimi, G.H., Klaunig, J.E., Nikiforov, A.I. (1996). Value of Liver Tissue Dosimetry Data to
Design and Interpret in vitro (Hepatocyte) Gap Junction Studies with Peroxisomal Proliferating Agents. The
Toxicologist, 30(1), 209.
193.
Brophy, D.F., Sowinski, K.M., Kraus, M.A., Clark, W.R., Moe, S.M., Klaunig, J.E., Mueller, B.A. (1996).
Peritoneal Dialytic Clearance of Small and Middle Molecular Weight Solutes in Automated Peritoneal
Dialysis. 1997 Spring Practice & Research Forum, American College of Clinical Pharmacy, Panama City,
Florida.
194.
Isenberg, J.S., Kolaja, K.L., Ayoubi, S.A., Watkins, J.B., Klaunig, J.E. (1996). The Role of Apoptosis in the
Inhibitory Effect of Rotenone on Wy-14,643-Induced Hepatic Focal Lesion Growth in Mice. Tenth
International Conference on Carcinogenesis and Risk Assessment, Austin, Texas.
195.
Kolaja, K.L., Isenberg, J.S., Stevenson, D.E., Walborg, E.F. Jr., Klaunig, J.E. (1996). Modulation of
Dieldrin-Induced Hepatic Focal Lesion Growth in Mice by Vitamin E. Tenth International Conference on
Carcinogenesis and Risk Assessment, Austin, Texas.
36
196.
Ayoubi, S.A., Xu, Y., Klaunig, J.E. (1996). Evaluation of Chemopreventive Agents Using the Syrian
Hamster Embryo (SHE) Cell Transformation Assay. Tenth International Conference on Carcinogenesis and
Risk Assessment, Austin, Texas.
197.
Xhang, H., Ayoubi, S.A., Baker, T.K., Klaunig, J.E. (1996). Application of the Syrian Hamster Embryo
(SHE) Cell Transformation Assay to Detect Non-genotoxic Carcinogens. Tenth International Conference on
Carcinogenesis and Risk Assessment, Austin, Texas.
198.
Bunting, K.L., Kolaja, K.L., Klaunig, J.E. (1996). Inhibition of Phenobarbital Induced Hepatic Lesion
Promotion by Dietary Restriction in Male B6C3F1 Mice. The Toxicologist, 30(1), 160-161.
199.
Kolaja, K.L., Stevenson, D.E., Walborg Jr., E.F., Klaunig, J.E. (1996). Reversibility of Promoter Induced
Hepatic Focal Preneoplastic Lesion Growth in Male B6C3F1 Mice. The Toxicologist, 30(1), 162.
200.
Steinmetz, K.L., Klaunig, J.E. (1996). Expression of Transforming Growth Factor- (TGF) in Established
Rat Hepatic Foci Treated With Tumor Promoters. The Toxicologist, 3 (1), 162-163.
201.
Kalimi, G.H., Lington, A.W., Klaunig, J.E. (1996). Gap Junction Intercellular Communication (GJIC)
Studies in Adult Primary Mouse Keratinocyte Cultures to Detect Potential Mouse Skin Tumor Promoters. The
Toxicologist, 30(1), 208.
202.
Li, Y., Noblitt, T.W., Zhang, W., Schymik, M., Fang, S., Kafrawy, A., Xu, Y., Klaunig, J.E., Stookey, G.K.
(1996). Safety Evaluation of Opalescence Sustained Release Whitening Gel. Journal of Dental Research, 75,
430.
203.
Ayoubi, S.A., Xu, Y., Klaunig, J.E. (1997). Application of the Syrian Hamster Embryo (SHE) Cell
Transformation Assay to Evaluate Potential Chemopreventive Agents. The Toxicologist, 36(1), 89.
204.
Kamendulis, L.M., Isenberg, J.S., Prow, T.W., Klaunig, J.E. (1997). Rotenone Reversal of Wy-14,643Induced Inhibition of Hepatic Gap Junctional Intercellular Communication. The Toxicologist, 36(1), 58.
205.
Isenberg, J.S., Kolaja, K.L., Ayoubi, S.A., Watkins, J.B., Klaunig, J.E. (1997). Inhibitory Effect of Rotenone
on WY-14-643 Induced Hepatic Focal Lesion Growth in Mice. The Toxicologist, 3 (1), 224.
206.
Steinmetz, K.L., Klaunig, J.E. (1997). Overexpression of Transforming Growth FactorLiver Cells does not Induce a Transformed Phenotype. The Toxicologist, 36(1), 222.
207.
Landis, H.E., Isenberg, J.S., Klaunig, J.E. (1997). Measurement of Gap Junctional Intercellular
Communication in Proliferating Rodent Liver. The Toxicologist, 36(1), 57.
208.
Prow, T.W., Zhang, H., Jiang, J., Klaunig, J.E. (1997). The Effects of Acrylonitrile on Gap Junctional
Intercellular Communication in DI TNC1 Rat Astrocytes. The Toxicologist, 36(1), 59.
209.
Ketcham, C.A., Klaunig, J.E. (1997). The Inhibition of Gap Junctional Intercellular Communication by WY14,643 through the Activation of Protein Kinase C and Oxidative Stress. The Toxicologist, 36(1), 223.
210.
Bunting, J., Kaster, J.K., Friedman, M.A., Klaunig, J.E. (1997). Effect of Acrylamide Treatment and
Glutathione Modulation on AP-1 and NFkB in Rat Glial Cells. The Toxicologist, 36(1), 298.
211.
Jiang, J., Xu, Y., Klaunig, J.E. (1997). Induction of Oxidative Stress in Rat Brain by Acrylonitrile. The
Toxicologist, 36(1), 94.
212.
Zwickl, C.M., Wierda, D., Klaunig, J.E. (1997). Quantitation of Thymus Cellularity and CD3/CD4/CD8
Thymocyte Subsets in Mice Treated with 1, 2-Epoxybutene-3, The Toxicologist, 36(1), 266.
37
213.
Cornwell, P.D., Moore, B.H., Smith, H.M., Sanders, R.A., Watkins II, J.B., Klaunig, J.E. (1997). Glutamyltranspeptidase (GGT) Activity in Rat Liver is Increased in Streptozotocin-Induced (STZ) Diabetes.
The Toxicologist, 3(1), 351.
214.
Zhang, H., Ayoubi, S.A., Baker, T.K., Klaunig, J.E. (1997). Effects of Nongenotoxic Carcinogens on
Morphological Transformation in the Syrian Hamster Embryo (SHE) Cell Assay. The Toxicologist, 36(1), 89.
215.
Klaunig, J.E. (1998). Oxidative Stress in Nongenotoxic Carcinogenesis. The Toxicologist, 42(1-S), 12.
216.
Ackley, D.C., Kaster, J.K., Kamendulis, L.M., Klaunig, J.E. (1998). The Role of Metabolism in Di-2Ethylhexyl Phthalate (DEHP) Induced Syrian Hamster Embryo (She) Cell Transformation. The Toxicologist,
42(1-S), 75.
217.
Zhang, H., Wang, Y., Jiang, J., Xu, Y., Klaunig, J.E. (1998). Prevention of Acrylonitrile Induced
Morphological Transformation in Syrian Hamster Embryo (She) Cells by Antioxidants. The Toxicologist,
42(1-S), 76.
218.
Kaster, J.K., Kamendulis, L.M., Friedman, M.A., Klaunig, J.E. (1998). Syrian Hamster Embryo (She) Cell
Transformation by Acrylamide and Hormones. The Toxicologist, 42(1-S), 76.
219.
Jiang, J., Xu, Y., Klaunig, J.E. (1998). Induction of Oxidative Stress in Rat Astrocytes. The Toxicologist,
42(1-S), 179.
220.
Herrman, C.E., Sanders, R.A., Klaunig, J.E., Watkins III, J.B. (1998). Decreased Apoptosis as a Mechanism
for Hepatomegaly in Streptozotocin-Induced Diabetic Rats. The Toxicologist, 42(1-S), 187.
221.
Isenberg, J.S., Klaunig, J.E. (1998). Reversal of Wy-14,643-Induced Inhibition of Apoptosis by Rotenone in
Liver Cells: A Potential Role for the Mitochondrial Permeability Transition. The Toxicologist, 42(1-S), 187.
222.
Smith, J.H., Isenberg, J.S., Pugh, Jr., G., Kamendulis, L.M., Ackley, D., Lington, A.W., Klaunig, J.E.
(1999). The Hepatic Effects of Di-Isononyl Phthalate (DINP) and Related Analogs in Rats and Mice. The
Toxicologist, 48(1-S), 234.
223.
Pugh Jr., G., Isenberg, J.S., Kamendulis, L.M., Clare, L.J., Brown, W.R., Lington, A.W., Ackley, D.C., Smith,
J.H., Klaunig, J.E. (1999). Absence of Liver Effects in Cynomolgus Monkeys Treated with Peroxisomal
Proliferators. The Toxicologist, 48(1-S), 235.
224.
McKee, R.H., Lington, A.W., Kamendulis, L.M., Pugh Jr., G., Smith, J.H., Klaunig, J.E. (1999). Species
Specificity for Hepatic Effects of DEHP on Gap Junction Intercellular Communication (GJIC), DNA
Synthesis and Peroxisomal Beta Oxidation (PBOx). The Toxicologist, 48(1-S), 234.
225.
Isenberg, J.S., Klaunig, J.E. (1999). Rotenone-Induced Apoptosis in Liver Cells: Involvement of the
Mitochondrial Membrane Permeability Transition (MPT). The Toxicologist, 48(1-S), 309.
226.
Zhang, H., Xu, Y., Kamendulis, L.M., Klaunig, J.E. (1999). Correlation Between the Formation of 8Hydroxy-2’-Deoxyguanosine (OH8dG) and Morphological Transformation in Syrian Hamster Embryo (SHE)
Cells. The Toxicologist, 48(1-S), 203.
227.
Xue, H., Kamendulis, L.M., Klaunig, J.E. (1999). A Potential Mechanism for 2-Butoxyethanol (2-BE)
Induced Mouse Liver Neoplasia. The Toxicologist, 48(1-S), 231.
228.
Kaster, J.K., Friedman, M.A., Jiang, J., Kamendulis, L.M., Klaunig, J.E. (1999). Tissue Specific Effects of
Acrylamide (AMD) on DNA Synthesis in Male Rats. The Toxicologist, 48(1-S), 231.
229.
Klaunig, J.E, Kamendulis, L.M. (1999). Role of Metabolism in Acrylonitrile (ACN) Carcinogenicity:
Studies in Syrian Hamster Embryo (SHE) Cells. The Toxicologist, 48(1-S), 367.
38
230.
Xu, Y., Kamendulis, L.M., Han, C., Chen, J., Heiser, C.M., Gordon, M., Mohler, E.R., Klaunig, J.E. (1999).
Examination of the Antioxidant Properties of Tea in Smokers and Nonsmokers. The Toxicologist, 48(1-S),
198-199.
231.
Zwickl, C.M., Klaunig, J.E., Wierda, D. (1999). Epoxybutene and Diepoxybutane Induce Apoptosis in
Mouse Thymocytes Through Different Pathways. The Toxicologist, 48(1-S), 89.
232.
Ackley, D.C., Kamendulis, L.M., Isenberg, J.S., Lington, A.W., Pugh Jr., G., Smith, J.H., Klaunig, J.E.
(1999). Reversibility of Phenobarbital and DEHP-Induced Inhibition of Gap Junction Intercellular
Communication (GJIC) and Induction of DNA Synthesis in the Rat. The Toxicologist, 48(1-S), 234.
233.
Kamendulis, L.M., Isenberg, J.S., Lington, A.W., Pugh Jr., G., Smith, J.H., Klaunig, J.E. (1999). DoseResponse and Time Course Studies of DEHP on Hepatic Peroxisomal -Oxidation (PBOx), Gap Junction
Intercellular Communication (GJIC) and DNA Synthesis in the Rat. The Toxicologist, 48(1-S), 234.
234.
Lahiri, D.K., Xu, Y., Klaunig, J.E., Baiyewu, O., Ogunniyi, Hall, K., Hendrie, H., Sahota, A. (1999). Effect
of Oxidative Stress on DNA Damage and Beta-amyloid Precursor Proteins in Lymphoblastoid Cell Lines
From African Populations. Conference on Oxidative/Energy Metabolism in Neurodegenerative Disorders.
The Rockefeller University, New York City.
235.
Zhang, H., Kamendulis, L.M., Klaunig, J E. (1999). Effects of Acrylonitrile on the Redox Status in Syrian
Hamster Embryo (SHE) Cells. Ohio Valley Society of Toxicology, Meeting on Experimental Biology,
Louisville, Kentucky.
236.
Xue, H., Aziz, R.M., Sun, N., Kamendulis, L.M., Xu, Y., Stoner, G.D., Klaunig, J.E. (1999). Inhibitory
Effects of Strawberry Extracts on Benzo (a) pyrene-Induced Morphological Transformation in Syrian Hamster
Embryo Cells. Ohio Valley Society of Toxicology, Meeting on Experimental Biology, Louisville, Kentucky.
237.
Meng, J., Xu, Y., Klaunig, J.E. (1999). The Effect of Tea Polyphenols on DNA Damage in SHE (Syrian
Hamster Embryo) Cells Induced by Hydrogen Peroxide Using Alkaline Comet Assay. Ohio Valley Society of
Toxicology, Meeting on Experimental Biology, Louisville, Kentucky.
238.
Park, J.J., Kamendulis, L.M., Klaunig, J.E. (1999). Effects of 2-Butoxyethanol, 2-Butoxyacetic Acid, and
Ferrous Sulfate on the Morphological Transformation of Syrian Hamster Embryo (SHE) Cells. Ohio Valley
Society of Toxicology, Meeting on Experimental Biology, Louisville, Kentucky.
239.
Gottschling, B.C., Kamendulis, L.M., Klaunig, J.E. (1999). Modulation of Focal and Non-Focal Hepatocyte
DNA Synthesis in 2-Butoxyethonal Treated Mice. Ohio Valley Society of Toxicology, Meeting on
Experimental Biology, Louisville, Kentucky.
240.
Meng, J., Xu, Y., Ren, B., Kamendulis, L.M., Dum, N., Klaunig, J. E. (2000). Reduction of White Blood Cell
DNA Damage (Comet Assay) by Black Tea Consumption in Smokers and Non-Smokers. The Toxicologist,
54, 164.
241.
Xu, Y., Ren, B., Klaunig, J. E. (2000). A Role for Oxidative Stress in the Promotion of Initiated Cells. The
Toxicologist, 54, 200.
242.
Kamendulis, L. M., Zhang, H., Klaunig, J. E. (2000). Role of Acrylonitrile Metabolism in the Induction of
Oxidative Stress and Morphological Transformation of Syrian Hamster Embryo (SHE) Cells. The
Toxicologist, 54, 200.
243.
Zhang, H., Kamendulis, L. M., Klaunig, J. E. (2000). Mechanisms for the Induction of Oxidative Stress in
Syrian Hamster Embryo (SHE) Cells by Acrylonitrile. The Toxicologist, 54, 200-201.
244.
Gottschling, B. C., Kamendulis, L. M., Klaunig, J. E. (2000). Modulation of Focal and Non-Focal Hepatocyte
DNA Synthesis in 2-Butoxyethanol Treated Mice. The Toxicologist, 54, 201.
39
245.
Park, J., Kamendulis, L. M., Klaunig, J. E. (2000). Effects of 2-Butoxyethanol, 2-Butoxyacetic Acid, and
Ferrous Sulfate on the Morphological Transformation of Syrian Hamster Embryo (SHE) Cells. The
Toxicologist, 54, 201.
246.
Xue, H., Aziz, R. M, Sun, N., Kamendulis, L. M., Xu, Y., Stoner, G. D., Klaunig, J. E. (2000).
Chemoprevention of B [A] P-Induced Morphological Transformation in Syrian Hamster Embryo Cells by
Strawberry Extracts. The Toxicologist, 54, 267
247.
Ren, B., Xu, Y., Kamendulis, L.M., Dum, N., Meng, J., Klaunig, J. E. (2000). Antioxidant Effects of Black
Tea in Smokers and Non-Smokers. The Toxicologist, 54, 308.
248.
Evan, A. P., Klaunig, J. E., Xu, Y., Connors, B. A., Lingeman, J. E., Willis, L. R. (2001). Oxidative Stress in
Both Kidneys after Shock-Wave Lithotripsy to One Kidney. (In press)
249.
Gottschling, B.C., Klaunig, J.E., Moomaw, C.R., Hailey, J.R., Maronpot, R.R., Nyska, A. (2001). Indium
Phosphide-Related Lesions in Rat Lungs Show Evidence of Oxidative Stress. 40th Annual Society of
Toxicology Meeting, San Francisco, California.
250.
Park, J., Kamendulis, L.M., Klaunig, J.E. (2001). Acrylamide-Induced Morphological Transformation in
Syrian Hamster Embryo Cells. 40th Annual Society of Toxicology Meeting, San Francisco, California.
251.
Xu, Y., Ren, B.G., Han, C., Wang, Y.H., Xue, H.W., Chen, J.S., Kamendulis, L.M., Klaunig, J.E. (2001).
Inhibition of B (A) P-Induced Morphological Transformation in Syrian Hamster Embryo (SHE) Cells by Tea
Components. 40th Annual Society of Toxicology Meeting, San Francisco, California.
252.
Kamendulis, L.M., Siesky, A.M., Park, J.J., Ren, B., Xu, Y., Klaunig, J.E. (2001). Examination of DNA
Synthesis and Oxidative Stress Following Treatment with Acrylonitrile in the Mouse. 40th Annual Society of
Toxicology Meeting, San Francisco, California.
253.
Gottschling, B.C., Park, J., Kamendulis, L.M., Klaunig, J.E. (2001). Modulation of Hepatic Cell Proliferation
and Oxidative Stress in 2-Butoxyethanol Treated Mice. 40th Annual Society of Toxicology Meeting, San
Francisco, California.
254.
Meng, J., Ren, B., Xu, Y., Kamendulis, L.M., Dum, N., Klaunig, J.E. (2001). Reduction of Oxidative DNA
Damage (Comet Assay) in White Blood Cells by Black Tea Consumption in Smokers and Nonsmokers. 40 th
Annual Society of Toxicology Meeting, San Francisco, California.
255.
Horn, K. H., Kamendulis, L.M., Goodlett, C.R., Klaunig, J.E. (2002). Antioxidant Protection Against
Ethanol-Induced Cell Loss in Cerebellar Granule Cell Cultures. The Toxicologist, 66(1-S), 13.
256.
Jiao, Z., Kamendulis, L.M., Xu, Klaunig, J.E. (2002). Acrylonitrile Effects on Gene Expression in Rat Brain
and Glial Cells. The Toxicologist, 306(1-S), 63.
257.
Lafferty, J. S., Kamendulis, L.M., Friedman, M.A., Klaunig, J.E. (2002). Mechanistic Studies of Acrylamide
Induced Carcinogenicity in the F344 Rat. The Toxicologist, 889 (1-S), 182.
258.
Kamendulis, L.M., Smith, D.J., Klaunig, J.E. (2002). Role of Choline Depletion in Diethanolamine induced
DNA Synthesis in Mouse Hepatocytes. The Toxicologist, 1507(1-S), 308.
259.
Klein, P.J., Kamendulis, L.M., Klaunig, J.E. (2002). Effect of Kupffer Cell Activation on Liver Focal Lesion
Growth. The Toxicologist, 1499(1-S), 306.
260.
Siesky, A.M., Kamendulis, L.M., Xu, Y, Klaunig, J.E. (2002). Mechanisms of Butoxyethanol
Carcinogenesis in the Rat and Mouse. The Toxicologist, 1500(1-S), 306.
40
261.
Xu, Y., Jiao, Z., Klaunig, J.E. (2002). Modulation of Transformed and Normal Syrian Hamster Embryo
(SHE) Cell Growth by Components of Green and Black Tea. The Toxicologist, 1511(1-S), 308.
262.
Smith D.J., Kamendulis, L.M., Klaunig, J.E. (2003). Kava Induces Hepatoxicity in Male B6C3F1 Mice. The
Toxicologist, 72(1-S), 199.
263.
Horn, K.H., Kamendulis, L.M., Goodlett, C.R., Klaunig, J.E. (2003). Acute Ethanol Exposure Increases
Catalase Activity, but does not Alter Glutathione Levels in Postnatal Day 3 Rat Pups. The Toxicologist, 72(1S), 622.
264.
Klaunig, J.E. (2003). Application of the Framework to the PPAR alpha Agonist Case Example. The
Toxicologist, 72(1-S), 170.
265.
Reed, J.M., Kamendulis, L.M., Klaunig, J.E. (2003). Examination of DNA Damage in Endothelial Cells
Following Treatment with 2-Butoxyethanol Using the Single Cell Gel Electrophoresis (comet) Assay. The
Toxicologist, 723(1-S), 206.
266.
Klein, P.J., Kamendulis, L.M., Klaunig, J.E. (2003). Effects of Dietary Cycine on the Growth of
Preneoplastic Hepatic Lesions in Male F344 Rats. The Toxicologist, 72(1-S), 212.
267.
Kamendulis, L.M., Smith, D.J., Jiao, Z., Klaunig, J.E. (2003). Species Differences in the Induction of
Hepatocellular DNA Synthesis by Diethanolamine. The Toxicologist, 72(1-S), 738.
268.
Gunasekar, P.G., Ramesh, T.T., Prabhakaran, K., Klaunig, J.E. (2003). Involvement of Caspase-3 Protese in
Dopaminergic Degenration Following Exposure to Methycyclopentadienyl Manganese Tricarbonyl (MMT).
The Toxicologist, 72(1-S), 352.
269.
Smith, D.J., Kamendulis, L.M., Klaunig, J.E. (2004). Effect of Trichloroacetic Acid in Male B6C3F1 Mouse
Hepatocytes. The Toxicologist, 72(1-S), 199.
270.
Reel, S, Kamendulis, L.M., Klein, P.J., Klaunig, J.E. (2004). Initiation-Promotion Studies of 1, 3Dichoropropene (1, 3-D) in Male F344 Rat Liver. The Toxicologist, 73(1-S), 117.
271.
Corthals, S.M., Kamendulis, L.M., Klaunig, J.E. (2004). Mechanisms for the Induction of DNA Damage
(comet) Assay Following 2-Butoxyethanol Exposure. The Toxicologist, 73(1-S), 223.
272.
Kamendulis, L.M., Smith, D.J., Klaunig, J.E. (2004). Species Differences in the Inhibition of Gap Junctional
Intercellular Communication (GJIC) by Diethanolamine. The Toxicologist, 73(1-S), 224.
273.
Kirman, C.R., Gargas, M., Klaunig, J.E., Collins, J., Starr, T., Stoother, D., Deskin, R. (2004). Updated
Cancer Risk Assessment of Acrylonitrile. The Toxicologist, 73(1-S), 368.
274.
Horn, K.H., Kamendulis, L.M., Goodlett, C.R., Klaunig, J.E. (2004). The Effect of Acute Ethanol Exposure
on Oxidative Stress and Caspase-3 Active Subunit Expression in Postnatal Day 4 Rat Cerebellum. The
Toxicologist, 73(1-S), 380.
275.
Fenner-Crips, P., Klaunig, J.E. (2004). Peroxisome Proliferator-induced Carcinogenesis. Risk Policy Report,
November Issue.
276.
Corthals, S.M., Kamendulis, L.M., Klaunig, J.E. (2005). Mechanisms of 2-Butoxyethanol Carcinogenesis.
The Toxicologist. 44th Annual Society of Toxicology Meeting.
277.
Kamendulis, L.M., Corthals, S.M., Klaunig, J.E. (2005). Evidence for the Involvement of the Kupffer Cell in
Hepatic Carcinogenesis. The Toxicologist. 44th Annual Society of Toxicology Meeting.
41
278.
Smith, D.J., Pu, X., Kamendulis, L.M., Klaunig, J.E. (2005). Comparative Effects of Trichloroacetic Acid on
Rodent and Human Hepatocytes: Role of Peroxisome Proliferator Activated Receptor (PPAR) α. The
Toxicologist. 44th Annual Society of Toxicology Meeting.
279.
Klaunig, J.E. (2006). Epigenetic Mechanisms of Hemangiosarcoma Induction. The Toxicologist, 90(1)331.
45th Annual Society of Toxicology Meeting.
280.
Pu, X., Kamendulis, L.M., Klaunig, J.E. (2006). Acrylonitrile Induces Oxidative Damage in Rat Glial Cells.
The Toxicologist. 90 (1) 955. 45th Annual Society of Toxicology Meeting.
281.
Klaunig, J.E. (2006). Role of the Kupffer cell in Mediating Hepatic Toxicity and Carcinogenesis. The
Toxicologist. 90 (1) 1122. 45th Annual Society of Toxicology Meeting.
282.
Kamendulis, L.M., Klaunig, J.E. (2006). Role of the Kupffer Cell in Modulation of Hepatic Neoplastic
Lesion Growth. The Toxicologist. 90 (1) 1125. 45th Annual Society of Toxicology Meeting.
283.
Corthals, S., Klaunig, J.E. and Kamendulis, L. M. (2007) Role of Kupffer Cells in Hepatocarcinogenesis.
The Toxicologist. 91(1), 758. 46th Annual Society of Toxicology Meeting.
284.
Pu, X., Kamendulis, L.M. and Klaunig, J.E. (2007). Induction of Oxidative Stress and Oxidative DNA
Damage in Rats by Acrylonitrile. The Toxicologist. 91(1), 193. 46th Annual Society of Toxicology Meeting.
285.
Klaunig, J.E. and Santostefano, M. J. (2007). Biliary Hyperplasia and Cholestasis: Relevance to Human
Risk Assessment. The Toxicologist. 91(1), 1309. 46th Annual Society of Toxicology Meeting.
286.
Kamendulis, L.M., Klaunig, J.E. (2007). Review of the Mutagenicity and Carcinogenicity of Acrylamide.
234th American Chemical Society National Meeting. The Cornucopia,. Boston, MA.
287.
Klaunig, J.E. (2007). Application of the Human Relevance Framework to the Analysis of Rodent Tumor
Data. American College of Toxicology 28th Annual Meeting, Charlotte, NC.
288.
Klaunig, J.E. (2007). PPAR Alpha Agonist and Hepatic Cancer: An Overview of the Mode of Action in the
Mouse. Society for Risk Analysis 2007 Annual Meeting, San Antonio, TX.
289.
Pu, X., Kamendulis, L.M., Klaunig, J.E. (2008). Comparison of Acrylonitrile-Induced Oxidative DNA
Damage in Cultured Rat and Human Astrocytes. The Toxicologist 92 (1), 109. 47th Annual Society of
Toxicology Meeting.
290.
Corthals, S.M., Owumi, S.E., Wang, Z-Y, Klaunig, J.E., Kamendulis, L.M. (2008). The Role of Kupffer Cell
in Ethanol-Induced Hepatocellular Growth. The Toxicologist 92(1), 121. 47th Annual Society of Toxicology
Meeting.
291.
Wang, Z-Y, Corthals, S.M., Klaunig, J.E., Kamendulis, L.M. (2008). Mechanisms for Enhanced TNFα
Epression by Wyeth 14,643 in Rat Kupffer Cells. The Toxicologist 92(1), 1219. 47th Annual Society of
Toxicology Meeting.
292.
Wang Z., Meng J., Jian J.Z., Xu, Y., Kamendulis, L.M., Klaunig, J.E. (2008). Protective effects of Black Tea
on Oxidative Damage in Humans. The Toxicologist 92(1), 124. 47th Annual Society of Toxicology Meeting.
293.
Philip, B.K., Rice, C.D., Kamendulis, L.M., Klaunig, J.E. (2008). Role of Kupffer Cell in Wyeth 14,643Induced Hepatocyte Proliferation in Naïve C3H Mice. The Toxicologist 92(1), 521. 47th Annual Society of
Toxicology Meeting.
294.
Klaunig, J.E. (2008). The Role of Oxidative Stress and Oxidative Damage in Chemical Carcinogenesis.
Toxicology and Risk Assessment Conference. Cincinnati, OH.
42
295.
Shanmugam, R., Kusumanchi, P., Crooks, P., Klaunig, J.E., Jordan, C., Nakshatri, H., Sweeney, C. (2008).
An Orally Bioavailable Parthenolide Analogue Inhibits both Subcutaneous and Metastatic Xenograft Growth
in Lung and Bladder Cancer Cell Lines and Is Independent of P53 Status. American Association for Cancer
Research Annual Meeting. San Diego, CA.
296.
Klaunig, J.E. (2008). Modifiers and Modulators of Chemical Carcinogenesis. 23 rd Aspen Cancer
Conference: Mechanisms of Toxicity, Carcinogenesis, Cancer Prevention and Cancer Therapy. Aspen, CO.
297.
Klaunig, J.E. (2008). Oxidative Stress & Cancer. Indiana University Simon Cancer Center Clinical Research
Office Employee Training. Indianapolis, IN.
298.
Wang, Z-Y., Corthals, S.M., Klaunig, J.E., Kamendulis, L.M. (2009). Reactive Oxygen Species-Related
Mechanisms Participate in the Sensitivity of M-CSF-Primed Rat Kupffer Cells to LPS Challenge. The
Toxicologist, 93(1), 428. 48th Annual Society of Toxicology Meeting.
299.
Wang, Z., Zhou, S., Klaunig, J.E. (2009). Involvement of Reactive Oxygen Species and Macrophages in
Tgoglitazone (TGZ)-Induced Hemangiosarcomas. The Toxicologist 93(1), 901. 48th Annual Society of
Toxicology Meeting.
300.
Harvilchuck, J.A., Pu, X., Klaunig, J.E., Carlson, G.P. (2009). Indicators of Oxidative Stress and Apoptosis
Following Exposure to Styrene and its Metabolites in Mouse Whole Lung and Clara Cells. The Toxicologist
93(1), 940. 48th Annual Society of Toxicology Meeting.
301.
Stagg, N.J., LeBaron, M.J., Kan, H.L., Stott, W., Yano, B.L., Gollapudi, B., Eisenbrandt, L., Klaunig, J.E.
(2009). Oxyfluorfen: Evaluation of the Mode of Action for Liver Tumors in Male Mice. The Toxicologist
93(1), 1496 48th Annual Society of Toxicology Meeting.
302.
Peat, T.J., Philip, B., Klaunig, J.E. (2009). Role of Kupffer Cell in Tumor Promotion Caused by NonGenotoxic Carcinogens Wyeth 14, 643 and Phenobarbital in Diethylnitrosamine Initiated C3H Mice. The
Toxicologist 93(1), 1638, 48th Annual Society of Toxicology Meeting.
303.
Philip, B., Peat, T. J., Kamendulis, L. M., Klaunig, J.E. (2009). Kupffer Cell Involvement in Phenobarbital
and Wyeth-14, 643 Induced Clonal Expansion of Preneoplastic Hepatic Lesions. The Toxicologist 93(1),
1639, 48th Annual Society of Toxicology Meeting.
304.
Zhou, S., Wang, Z., Pu, X., Klaunig, J.E. (2009). Modulation of Acrylonitrile on Mitochondrial Gene
Expression and Membrane Potential. The Toxicologist 93 (1), 1644. 48th Annual Society of Toxicology.
305.
Pu, X., Kamendulis, L. M., Klaunig, J.E. (2009). Effects of Cryopreservation on Alkaline and FPG-Modified
Comet Assay in Whole Blood and Isolated Lymphocytes. The Toxicologist 93(1), 1910. 48th Annual Society
of Toxicology Meeting.
306.
Klaunig, J.E. (2009). PPARγ: Relevance of Rodent Tumours to Man. British Toxicology Society Annual
Congress 2009, University of Warwick, United Kingdom.
307.
Shi, Y., Klaunig, J.E. (2009). Inhibition of GJIC in the Primary Mouse Hepatocyte by the Technical
Toxaphene. Cancer Research Day, Indiana University Melvin & Bren Simon Cancer Center, Indianapolis,
Indiana.
308.
Wang, Z., Zhou, S., Klaunig, J.E. (2009). Involvement of Reactive Oxygene Species and Macrophages in
Troglitazone (TGZ)-Induced Hemangiosarcomas. Cancer Research Day, Indiana University Melvin & Bren
Simon Cancer Center, Indianapolis, Indiana.
309.
Wang, Z.Y, Klaunig, J.E. , Kamendulis, L.M. (2009). ROS-Related Mechanisms Participate in the
Sensitivity of M-CSF-Primed Rat Kupffer Cells to LPS Challenge. Cancer Research Day, Indiana University
Melvin & Bren Simon Cancer Center, Indianapolis, Indiana.
43
310.
Pu, X, Kamendulis, L.M., Klaunig, J.E. (2009). Effects of Cryopreservation on Alkaline and FPG-Modified
Comet Assay in Whole Human Blood and Isolated Lymphocytes. Cancer Research Day, Indiana University
Melvin & Bren Simon Cancer Center, Indianapolis, Indiana.
311.
Zhou, S., Wang, Z., Wang, Z.Y., Klaunig, J.E. (2009). Modulation of Antioxidants on Sensitivity of Lung
Cancer Cells to Chemotherapeutic Agents. Cancer Research Day, Indiana University Melvin & Bren Simon
Cancer Center, Indianapolis, Indiana.
312.
Peat, T.J., Philip, B.K., Klaunig, J.E. (2009). Role of Kupffer Cell in Tumor Promotion Caused by NonGenotoxic Carcinogens Wyeth 14,643 and Phenobarbital in Diethylnitrosamine Initiated C3H Mice. Cancer
Research Day, Indiana University Melvin & Bren Simon Cancer Center, Indianapolis, Indiana.
313.
Klaunig, J.E. (2009). Oxidative Stress/Damage in Carcinogenesis. Society of Toxicological Pathology
Annual Meeting, Washington, D.C.
314.
Klaunig, J.E. (2009). Hemangiosarcomas in Rodents – Relevance to Humans? Toxicology Forum, Aspen,
Colorado.
315.
Klaunig, J.E., Snyder, R. (2009). Implication of recent data on benzene risk assessment: Weight of evidence
for mode of action/human relevance and dose-response: Critical data gaps. Benzene 2009: Health Effects
and Mechanisms of Bone Marrow Toxicity Implications for t-AML and the Mode of Action Framework,
Munich, Germany.
316.
Pu, X., Wang, Z., Hocevar, B.A., Kamendulis, L.M., Klaunig, J.E. (2010). Effects of antioxidants on
acrylonitrile-induced oxidative stress in female F344 rats. The Toxicologist 94(1). 526. 49th Annual Society of
Toxicology Meeting.
317.
Wang, Z-Y, Klaunig, J.E., Hocevar, B., Kamendulis, L.M. (2010). Characterization of an immortalized
murine Kupffer cell line for use in toxicological studies. The Toxicologist 94(1), 1965. 49th Annual Society
of Toxicology Meeting.
318.
Peat, T.J., Kushida, M., Kamendulis, L.M., Klaunig, J.E. (2010). Kupffer cells participate in bis(2ethylhexyl)phthalate and Phenobarbital-induced hepatic tumor promotion. The Toxicologist 94(1), 524. 49th
Annual Society of Toxicology Meeting.
319.
Hocevar, B.A., Wang, Z-Y, Klaunig, J.E., Kamendulis, L.M. (2010). Role of TGF -mediated hepatocyte
epithelial to mesenchymal transition (EMT) in alcohol-induced liver fibrosis. The Toxicologist 94(1), 1634.
49th Annual Society of Toxicology Meeting.
320.
Kushida, M., Corthals, S.M., Peat, T.J., Baird, T.D., Klaunig, J.E. (2010). Dose-dependent induction of
hepatic preneoplastic lesions by diethlynitrosamine in C57BL/6 mice. The Toxicologist 94(1), 523. 49th
Annual Society of Toxicology Meeting.
321.
Lamb, J.C., Walker, C.L., Neal, B.H., Klaunig, J.E. (2010). Inhibition of gap junction intercellular
communication (GJIC) in mouse liver cells by technical toxaphene and toxaphene congeners. The
Toxicologist 94(1), 525.
322.
Hahn, N.M., Jung, J., Dantzer, J., Philips, S., Patel, Y.R., Carr, K.A., Mohammadi, Y., Magjuka, D., Camp,
C., Dropcho, E.F., Knight, J.A., Moore, M.L., Reed, A.D., Waddell, M.J., Klaunig, J.E., Li, L., Sweeney,
C.J., Skaar, T.C. (2011). A case control study examining associations of germ—line oxidative DNA repair
single nucleotide polymorphisms with lethal prostate cancer risk. Journal of Clinical Oncology. 2011 ASCO
Annual Meeting.
323. Hornsby WE, Khouri MG, Lakoski SG, Ainslie P, Smirl J, West M, Lane A, Coan A, Ona FV, Klaunig JE,
Koceja DM, Chapman RF, Jones LW. (2012). Autonomic and Cardiovascular Function of Hormone-Receptor
Positive Breast Cancer Patients Following Treatment with Anthracycline-Containing Chemotherapy. Poster
44
will be presented at the 59th American College of Sports Medicine Annual Meeting, San Francisco CA, USA
(2012, May).
324. Ewert A, Klaunig JE, Wang Z, Conklin S. (2013). Natural Environments and Stress: Mitigation of Cortisol
Through Visitation to an Outdoor Setting.
STUDENTS:
Graduate Students:
J.E. Klaunig: Major Advisor
Doctoral Students
Name
Degree
1. Janine R. Shulok
(Ph.D.)
2. Bruce A. Barut
(Ph.D.)
3. Randall J. Ruch
(Ph.D.)
4. Christopher Weghorst (Ph.D.)
5. Xie Jian
(Ph.D.)
6. Lydia D. Schafer
(Ph.D.)
7. Karen Steinmetz
(Ph.D.)
8. Stephen Bachowski (Ph.D.)
9. Kyle Kolaja
(Ph.D.)
10. Craig Zwickl
(Ph.D.)
11. Jiazhong Jiang
(Ph.D.)
12. Jason Isenberg
(Ph.D.)
13. Elizabeth Julian
(Ph.D.)
14. Jiazhong Zhang
(Ph.D.)
15. Kristin Horn
(Ph.D.)
16. Minerva Mercado
(Ph.D.)
17. Aditya Bansal
(Ph.D.)
18. Solomon Owumi
(Ph.D.)
19. Yinbin Liu
(Ph.D)
20. Rami Saadeh
(Ph.D)
Period of Training
1982-1987
1982-1988
1984-1988
1985-1989
1987-1990
1989-1991
1991-1996
1992-1995
1992-1996
1992-1998
1995-1998
1994-1999
1996-1999
1996-2000
2001-2004
2005-2009
2006- 2010
2006- 2010
2011-present
2011-present
Location
Medical College of Ohio (Pathology)
Medical College of Ohio (Pathology)
Medical College of Ohio (Pathology)
Medical College of Ohio (Pathology)
Medical College of Ohio (Pharmacology)
Medical College of Ohio (Pathology)
Indiana University (Pharm. /Toxicology)
Indiana University (Pharm. /Toxicology)
Indiana University (Pharm. /Toxicology)
Indiana University (Pharm. /Toxicology)
Indiana University (Pharm. /Toxicology)
Indiana University (Pharm. /Toxicology)
Indiana University (Neurobiology)
Indiana University (Pharm. /Toxicology)
Indiana University (Neurobiology)
Indiana University (Pharm. /Toxicology)
Indiana University (Biochemistry)
Indiana University (Toxicology)
Indiana University (Environmental Health)
Indiana University (Environmental Health)
Master’s Students
1. Norman E. Schultz
2. Patrick J. Schafer
3. Joseph Siglin
4. James Hartnett
5. Michael Merceica
6. Jerald Wilkinson
7. Luann Schutrum
8. John McKenzie
9. Rusty Rush
10. Cao Jin
11. Jason Johnson
12. Cynthia Ketcham
13. Jamie Bunting
14. Rod Thompson
15. Liu Yang
16. Hongwei Xue
1985-1988
1985-1988
1986-1990
1988-1990
1989-1991
1989-1991
1989-1991
1989-1992
1989-1993
1989-1994
1993-1996
1994-1997
1995-1997
1994-1998
1997-2000
1998-2000
Medical College of Ohio (Pathology)
Medical College of Ohio (Pathology)
Medical College of Ohio (Pathology)
Medical College of Ohio (Pathology)
Medical College of Ohio (Pathology)
Medical College of Ohio (Pathology)
Medical College of Ohio (Pathology)
Medical College of Ohio (Pathology)
Medical College of Ohio (Pathology)
Indiana University (Pharm. /Toxicology)
Indiana University (Pharm. /Toxicology)
Indiana University (Pharm. /Toxicology)
Indiana University (Pharm. /Toxicology)
Indiana University (Pharm. /Toxicology)
Indiana University (Pharm. /Toxicology)
Indiana University (Pharm. /Toxicology)
(M.S.)
(M.S.)
(M.S.)
(M.S.)
(M.S.)
(M.S.)
(M.S.)
(M.S.)
(M.S.)
(M.S.)
(M.S.)
(M.S.)
(M.S.)
(M.S.)
(M.S.)
(M.S.)
45
17.
18.
19.
20.
21.
22.
23.
Angela Knapp Siesky (M.S.)
Jeffery Lafferty
(M.S.)
Jinfeng Meng
(M.S.)
Stacey Corthals
(M.S.)
David Smith
(M.S.)
Lee Stone
(M.S.)
Dante Villaviencencio (M.S.)
1999-2001
2000-2002
1997-2001
2001- 2004
2001- 2003
2003-2006
2003-2006
Indiana University (Pharm. /Toxicology)
Indiana University (Pharm. /Toxicology)
Indiana University (Pharm. /Toxicology)
Indiana University (Pharm. /Toxicology)
Indiana University (Pharm. /Toxicology)
Indiana University (Pharm. /Toxicology)
Indiana University (Pharm. /Toxicology)
Postdoctoral Fellows, Visiting Scientists, Research Scientists
J.E. Klaunig: Advisor
1. Ann Kwiatowski, Ph.D.
2. Saw Yin OH, Ph.D.
3. Gulam Kalimi, Ph.D.
4 Lisa Kamendulis, Ph.D.
5 David Ackley, Ph.D.
6. JuLee Kaster, Ph.D.
7. JJ Park, Ph.D.
8. BaoGuo Ren, M.D.
9. Guimeng Li, M.D.
10. Barbara Gottschling, DVM, Ph.D.
11. Zhenquan Jiao, Ph.D.
12. Patrick Klein, Ph.D.
13. Xinzhu Pu, Ph.D.
14. Solomon Owumi
15. Binu Philip, Ph.D.
16. Zemin Wang, Ph.D.
17. Shaoyu Zhou, Ph.D.
18. Yuhui (Sherry) Shi, Ph.D.
19. Raj Sellamuthu, Ph.D.
20. Zemin Wang , MD, Ph.D
21. Shaoyu Zhou, MD, PhD,
22. Jianyong Zhang, Ph.D.
23. Zuoqing Yuan, Ph.D.
24. Maud De Meyer, MS
1993-1996
1995-1996
1994-1997
1996 -2004
1997-1999
1996-1999
1998-2001
1998-2001
1999-2000
1999-2001
2001-2003
2001-2003
2003-2006
2006-2007
2006-2008
2007-2010
2008-2010
2008-2009
2011-2012
2012-2014
2012-2014
2013-2014
2013-2014
2012-2014
Service on Graduate Committees:
Dominick Scaramuzzino (Ph.D.)
William Gunning (Ph.D.)
Swapna Mandal (Ph.D.)
Kallol Chadhuri (Ph.D.)
Salah Awad (Ph.D.)
Hong Xiang Zu (Ph.D.)
Norman Grimes (Ph.D.)
Subhanker Bandyopadaya (Ph.D.)
Daniel Wojta (Ph.D.)
Martha Moore (M.S.)
Melody Superczynski (M.S.)
Medical College of Ohio
Medical College of Ohio
Medical College of Ohio
Medical College of Ohio
Medical College of Ohio
Medical College of Ohio
University of Toledo
Medical College of Ohio
University of Toledo
Medical College of Ohio
Medical College of Ohio
46
Gabriela Rodwell (Ph.D.)
Elaine Daniel (Ph.D.)
Mary Jeanne O'Gara (Ph.D.)
Liu Yang (Ph.D.)
Zhang Peng (Ph.D.)
Stacy Corthals (Ph.D.)
Matthew Brittain (Ph.D.)
Natalia Van Duyn (Ph.D.)
Whitney Hornsby (Ph.D.)
Sylvanna Bielko (Ph.D.)
Aditya Bansal
(Ph.D.)
Whitney Hornsby (Ph.D.)
Waleed Abdel-Aziz, (Ph.D.)
Yi-Chun Lin (Ph.D.)
Medical College of Ohio
Medical College of Ohio
Indiana University
Indiana University
Indiana University
Indiana University
Indiana University
Indiana University
Indiana University
Indiana University
Indiana University
Indiana University
Indiana University
Indiana University
Research Advisor (Medical Students):
Robert Perry
John Del Valle
Lawrence Satkowiak
Christopher Krall
Deborah Lucas
Steven Knipe
Scott Lilly
Patrick Schafer
Timothy O'Donnell
Laura Barlow
Matthew Hufford
Sherry Pittman
University of Maryland
Medical College of Ohio
Medical College of Ohio
Medical College of Ohio
Medical College of Ohio
Medical College of Ohio
Medical College of Ohio
Medical College of Ohio
Medical College of Ohio
Indiana University
Indiana University
Indiana University
Research Advisor (Undergraduate Students):
Rubina Dalal
Indiana University
Steve Coachys
Indiana University
Rebecca Little
Indiana University
Rae Coflin
Indiana University
Siar Ayoubi
Indiana University
Carleen James
Indiana University
Ralph Arrington
Indiana University
Celina Acuna
Indiana University
Emily Scott
Indiana University
Megan Agnew
Indiana University
Research Advisor (Herbert Summer Scholars Institute Program):
Teresa Demeritte
Lashanna Johnson
Jackson State University
Xavier University
Teaching Experience:
Course Title
General Pathology
Students
Medical Students
General Pathology
Medical Students
Participation
Lecturer in Cell Injury
Lecturer in Carcinogenesis
Lecturer in Environmental Pathology
Laboratory Instructor in Pathology
47
Oncology
General Pathology
Cell Biology
Methods in Tissue Culture
Transmission Electron Microscopy.
General Pathology
Environmental Toxicology
Cellular and Molecular Toxicology
Medical Pharmacology
Research in Toxicology
Clinical/Forensic Toxicology
Cancer Chemoprevention
Chemical Carcinogenesis
Principles of Toxicology
Advanced Toxicology
Graduate Students
Nursing Students
Lecturer in Chemical Carcinogenesis
Lecturer in Cell Injury
Lecturer in General Pathology
Graduate Students
Lecturer
Graduate Students
Lecturer
Graduate Students
Lecturer
Physical Therapy Students Lecturer in Cell Injury
Course Director
Graduate Students
Lecturer and Course Director
Graduate Students
Lecturer and Course Director
Medical Students
Lecturer in Principles of Toxicology
Graduate Students
Lecturer and Course Director
Graduate Students
Lecturer and Course Director
Graduate Students
Lecturer and Course Director
Graduate Students
Lecturer and Course Director
Graduate Students
Lecturer and Course Director
Graduate Students
Lecturer and Course Director
IUBloomington
SPEA-E 625
INVITED SPEAKER
1979
“Human Hepatocyte Culture”, National Cancer Institute, Bethesda, Maryland
1981
“Methods in Hepatocyte Culture”, W. Alton Jones Science Center, Lake Placid, New York
1990
“Use of Small Fish Species in Toxicity and Carcinogenicity Testing”, National Cancer Institute,
Bethesda, Maryland
1982
“Studies on Nongenotoxic Carcinogenesis”, Dept. of Biology, Bowling Green State University,
Bowling Green, Ohio
1987
“Hepatic Toxicity and Carcinogenesis”, School of Pharmacy, University of Toledo, Toledo, Ohio
1987
Chairman, “Oncogenesis” Session, Society of Toxicology 26th Annual Meeting
1988
Chairman, “Tumor Promotion” Poster/Discussion Session, Society of Toxicology 27th Annual
Meeting
1988
“Modulation of Cell to Cell Communication in the Cancer Process”, National Cancer Institute,
Frederick, MD
1988
“Gap Junctions in Cancer”, Dept. of Pathology, University of Maryland, Baltimore, Maryland
1988
“Role of Gap Junctional Intercellular Communication in the Stages of Carcinogenesis”,
Toxicology
Program, School of Public Health, Johns Hopkins University, Baltimore, Maryland
1988
“Mechanisms of Nongenotoxic Carcinogenesis”, Department of Pharmacology, Michigan State
University, East Lansing, Michigan
1988
“Current Perspectives on Nongenotoxic Carcinogenesis”, Toxicology Program, University of
Illinois, Champaign, Illinois
1988
“Mechanisms of Chemical Carcinogenesis”, Toxicology Department, General Motors
Corporation,
Detroit, Michigan
1988
“Gap Junction Modification in Nongenotoxic Carcinogenesis”, Conference on Toxicological
Implications of Gap Junctions, Michigan State University, East Lansing, Michigan
1988
“Cell to Cell Communication in Murine Hepatic Carcinogenesis”, Conference on Mouse Liver
Carcinogenesis, Austin, Texas
1988
“Mechanisms of Nongenotoxic Carcinogenesis”, Dow Chemical Company, Midland, Michigan
1989
“Current Understanding of Chemically Induced Hepatic Cancer”, University of Cincinnati,
Cincinnati, Ohio
48
1989
1989
1989
1989
1990
1990
1991
1991
1992
1992
1992
1992
1992
1992
1992
1993
1993
1993
1993
1993
1993
1993
1993
1994
1994
1994
1994
1994
“Studies on Nongenotoxic Carcinogenesis”, Michigan Society of Toxicology Annual Meeting,
Ann
Arbor, Michigan
“Role of Cell to Cell Communication in the Cancer Process”, Fifth International Conference on
Environmental Mutagens, Cleveland, Ohio
“Effect of Nongenotoxic Carcinogens on Mouse Liver Proliferation”, Conference on Role of Cell
Proliferation in Carcinogenesis, Austin, Texas
Chairman, “Hepatic Toxicity of Halogenated Hydrocarbon Mixtures” Poster/Discussion Session,
Society of Toxicology, 28th Annual Meeting
“Nongenotoxic Carcinogenesis and Cell to Cell Communication”, U.S. EPA Conference on Role
of Gap Junctions in Toxicology, EPA, Washington, DC
“Intercellular Communication in the Endothelium”, Endothelial Cell Injury Symposium, Toledo,
Ohio
“Altered Expression of Gap Junctions During Mouse Liver Tumorigenesis”, 3rd Workshop on
House Liver Tumors, ILSI Health and Environmental Sciences Institute, Arlington,
Virginia
“Role of Cell Proliferation in Mouse Liver Carcinogenesis”, Smithkline Beecham, King of
Prussia, Pennsylvania
“Gap Junctions”, Chemical Manufacturers Association, Washington, DC
“Role of Gap Junctional Communication in Hepatocarcinogenesis”, Summer Toxicology Forum,
Aspen, Colorado
“Modulation of Cell Replication in Hepatic Tumorigenesis”, Ohio Valley Society of Toxicology
Indianapolis, Indiana
“Role of Cell Proliferation in Non-Genotoxic Carcinogenesis in the Liver”, Midwest Regional
Chapter of the Society of Toxicology, Abbott Park, Illinois
“Pharmacology of Alcohol”, Indiana Excise Police, Indiana Law Enforcement Academy,
Plainfield, Indiana
“Modulation of Gap Junction Gene Expression During Mouse Liver Tumor Carcinogenesis”, 4 th
Workshop on Mouse Liver Tumors, ILSI Health and Environmental Sciences Institute,
Washington, D.C.
“Principles of Toxicology”, Indiana Environmental Management Group, Indianapolis, Indiana
“Mechanisms of Hepatocarcinogenesis”, Medical Science Program, Indiana University
Bloomington, Indiana
“Hepatic Tumor Promotion: Possible Mechanisms”, Department of Pharmacology and
Toxicology, School of Pharmacy, Purdue University, West Lafayette, Indiana
“Pharmacology and Toxicology of Alcohol in Driving While Intoxicated”, Indiana Prosecuting
Attorney's Council, Indianapolis, Indiana
“Applications of Primary Hepatocyte Cultures for the Study of Chemically Induced Cancer”,
Tissue Culture Association Meeting, San Diego, California
“Mechanisms of Nongenotoxic Carcinogenesis”, Society of Toxicology, 32 nd Annual Meeting,
New Orleans, Louisiana
“Novel Mechanisms of Hepatic Cell Injury”, American Society for Pharmacology and
Experimental Therapeutics, San Francisco, California
“Toxicology”, Indiana State Police, Indiana Law Enforcement Academy, Plainfield, Indiana
“Modulation of Cell to Cell Communication in Hepatic Tumor Promotion”, International
Conference on Carcinogenesis and Risk Assessment, Austin, Texas
“Chemical Carcinogenesis”, Department of Biology, Purdue University, Indianapolis, Indiana
“Non-genotoxic Mechanisms in Hepatocarcinogenesis”, Department of Pharmacology &
Toxicology, Michigan State University, East Lansing, Michigan
“Studies on Dieldrin Induced Mouse Liver Cancer: Implication to Risk Assessment”, U.S.
Environmental Protection Agency, Washington, D.C.
“Mechanisms of Dieldrin Induced Mouse Hepatocarcinogenesis”, Mechanisms of Toxicity and
Carcinogenesis 9th Aspen Cancer Conference, Aspen, Colorado
“Current Understanding of the Role of Oxidative Stress in Peroxisome Proliferation Induced
49
1995
1996
1995
1995
1996
1994
1995
1995
1995
1995
1995
1996
1996
1996
1996
1997
1996
1996
1996
1997
1996
1996
1997
1997
1998
1997
1997
1997
1997
Hepatic Cancer”, Research Update on Peroxisome Proliferation, International Life
Sciences Institute, Society of Toxicology, 33rd Annual Meeting, Dallas, Texas
“Role of Oxidative Stress in Mouse Liver Carcinogenesis”, 5th Workshop on Mouse Liver
Tumors, International Life Sciences Institute, Washington, D.C.
“Mechanism of Rodent Liver Carcinogenesis”, Procter and Gamble Co. Cincinnati, Ohio
“Potential Mechanisms of Non-Genotoxic Carcinogenesis:, Johns Hopkins University, Baltimore,
Maryland
“Diagnosis, Treatment and Removal of Lead/Other Heavy Metals” Indiana Public Health
Foundation, Inc., Indianapolis, Indiana
Chairman, “Cell Proliferation: Biological Effects and Carcinogenic Risk Assessment
Symposium”, International Congress of Toxicology, Seattle, Washington
"Oxidative Stress in Nongenotoxic Carcinogenesis", International Congress of Toxicology,
Seattle, Washington
“Pharmacology and Toxicology of Alcohol (Ethanol) as it Relates to Impaired Driving”,
Governor’s Council on Dangerous and Impaired Driving, Indianapolis, Indiana
“Everything You Ever Wanted to Ask a Toxicologist about Alcohol, Drugs and Driving”,
Prosecuting Attorneys Council, Winter Conference, Indianapolis, Indiana
“Blood Alcohol Content: 0.10 v. 0.08”, Senate Committee on Criminal Justice Issues,
Indianapolis, Indiana
“Modulation of Intercellular Communication & Oxidative Stress as Important Mechanistic
Endpoints in Toxicity”, DuPont Co., Newark, Delaware
“Mechanisms of Non-Genotoxic Carcinogenesis”, Michigan State University, Lansing, Michigan
“Toxicology and the Law”, Health Law Colloquium, Indiana University School of Law,
Indianapolis, Indiana
“The Expert Witness”, Indiana Continuing Legal Education Forum, Indianapolis, Indiana
“Toxicology”, Indiana Judicial Conference, Nashville, Indiana
“State Department of Toxicology”, Indiana Association of Chiefs of Police, Clarksville, Indiana
“Oxidative Damage and Tumor Promotion”, 1996 BELLE Conference on Toxicological Defense
Mechanisms and the Shape of Dose-Response Relationships, Research Triangle Park,
North Carolina
“Role of Oxidative Stress in Chemically Induced Cancer”, 10th International Conference on
Carcinogenesis and Risk Assessment, Austin, Texas
“Forensic Toxicology”, Indiana Prosecuting Attorneys Council, Winter Conference, Indianapolis,
Indiana
“Application of Gap Junctional Intercellular Communication Modification in
Toxicology and Cancer Assessment” Chairman, Session, Toxicology Forum, Aspen,
Colorado
“Species Specific Modulation of Hepatic Gap Junctions”, Toxicology Forum, Aspen, Colorado
“Updates on Acrylonitrile Cancer Mechanism Studies”, Acrylonitrile Group Annual Meeting,
Orlando, Florida
“Alcohol and Drug Testing”, Indiana Law Enforcement Academy, Plainfield, Indiana
“Chemical Carcinogenesis”, Mid-American Toxicology Course, Kansas City, Kansas
Chairman, “Growth Regulation” Session, Mechanisms of Susceptibility to Mouse Liver
Carcinogenesis Conference, Chapel Hill, North Carolina
“Role of Oxidative Stress in Mouse Liver Tumorigenesis”, Mechanisms of Susceptibility to
Mouse Liver Carcinogenesis Conference, Chapel Hill, North Carolina
Prosecutor’s Breath Test School
“Mechanistic Basis Supporting Validity of Methodology: Mechanisms of Transformation”,
COVANCE Syrian Hamster Embryo Cell Morphological Transformation System
Workshop, Vienna, Virginia
“Research Perspective: Chemopreventative”, COVANCE Syrian Hamster Embryo Cell
Morphological Transformation System Workshop, Vienna, Virginia
“Tea Consumption and Oxidative Stress in Smokers and Non-Smokers: Preliminary Results from
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1998
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1998
1998
1999
1999
1999
1999
1999
1999
1999
1999
1999
2000
2001
2002
2003
2003
2003
2003
2004
2004
U.S. and China Studies”, Tea and Health Advisory Board Meeting, Englewood Cliffs,
New Jersey
North Carolina Society of Toxicology, RTP, North Carolina
Exxon Biomedical Sciences, Newark, New Jersey
“Oxidant Induced Carcinogenesis”, Chemical Safety for the 21 st Century, 8th International
Congress of Toxicology, Paris, France
“Oxidative Stress in Non-Genotoxic Carcinogenesis”, Society of Toxicology Symposium, Seattle,
Washington
“Clinical Studies”, Second International Scientific Symposium on Tea and Human Health,
Washington, D.C.
“Acetonitriles – Group Discussion”, Workshop on Mechanistic Research of Disinfection ByProducts”, International Life Sciences Institute, Health and Environmental Sciences
Institute, Washington, D.C.
“Health Effects of Smoking and Tobacco”, Tobacco in America: Lungs, Liars, and Lawyers,
Indiana University-Purdue University, Indianapolis, Indiana
“Cellular Effects of Acrylonitrile in Astrocytes”, Toxicology Forum, Washington, D.C.
“Mechanisms of Nongenotoxic Carcinogenesis”, North Carolina Society of Toxicology, Annual
Meeting, Research Triangle Park, North Carolina
“Anti-Carcinogenic Actions of Food Components”, Central Indiana District Dietetic Association
Conference, Indianapolis, Indiana
“Principles of Toxicology”, Department of Hazardous Materials Management/Local Emergency
Planning Committee, Marion County Health Department, Indianapolis, Indiana
“Mechanisms of Nongenotoxic Carcinogenesis”, University of Kentucky, Toxicology Graduate
Program, Lexington, Kentucky
“Indiana Alcohol and Drug Testing”, Indiana Prosecuting Attorneys Council, Indianapolis,
Indiana
“Environmental Toxicology”, School of Public and Environmental Affairs, Indiana University,
Indianapolis, Indiana
Department of Hazardous Materials Management/ Local Emergency Planning Committee, Marion
County Health Dept. “Principles of Toxicology”
“Oxidative Stress and Sensitive Clinical Biomarkers”, Toxicology Advisory Committee
Symposium, St. Louis, Missouri
“Sufficiency of Evidence in Drug Testing in Schools”, Wayne Township School District,
Indianapolis, Indiana
“Science Advisory Board's review of the Draft Chloroform Risk Assessment and Related Issues in
The Proposed Cancer Risk Assessment Guidelines”, US EPA, Washington, D.C.
“Mechanisms of Nongenotoxic Carcinogenesis”, Toxicology Scholars Colloquium, University of
Connecticut, Storrs, Connecticut
“Mode of Cancer Action in the Rat Brain”, US AN Group/CEFIC/Japan AN Group-Strategic
Planning Meeting
“Properly Identifying Students Who are Under the Influence of Drugs,” Indiana School Boards
Association, School Law Seminar, Indianapolis, Indiana
“Smoke-Free presentation” Tobacco Free IUPUI Coalition, Indiana University School of
Medicine, Department of Public Health, October 15, Indianapolis, Indiana
“Prosecutor Mentor Program – Operating While Intoxicated”, Indiana Prosecuting Attorneys
Council, Indianapolis, Indiana
“Carcinogenesis” The American Chemical Society Presents courses on Chemical Mechanisms in
Toxicology November 6-7. Philadelphia, PA
“Forensic Toxicology” Purdue University, School of Health Sciences, November 18, Lafayette,
Indiana
“Mechanisms of Carcinogenicity and Toxicity of Acrylamide” Division of Agricultural and Food
Chemistry of the American Chemical Society, Spring National Meeting, Anaheim, CA.
“Oxidative Stress in Drug Induced Hepatoxicity”, the 3 rd Annual Symposium on Drug-Induced
Hepatotoxicity, September 20-21. Philadelphia, PA
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2004
2004
2004
2004
2004
2004
2005
2005
2005
2005
2006
2006
2006
2006
2006
2006
2007
2008
2007
2007
2007
2007
2007
2007
2007
2007
“Human Relevance of Rodent Liver Tumors” Toxicology Forum, July 22, Aspen, CO
October 21st Meeting, University of Delaware, Newark, DE
“Cell Surface and Nuclear Receptor Biology”, Mechanisms of Toxicity Conference, July 25 Colby
College, Waterville, Maine
“Oxidative Stress in Humans”, Endocrine Research Conference, Indiana University School of
Medicine, Indianapolis, Indiana.
“SHE: A Cell Transformation Assay, Historical Perspectives, Techniques and Application.”
Environmental Mutagen Society 35th Annual Meeting October 2-6, Pittsburgh, PA
“Non-Genotoxic Carcinogens and the SHE Cell Assay” Genetic Toxicology Association, October,
University of Delaware, Newark, DE.
“Role of the Kupffer Cell in Hepatic Toxicity”, Borenger Ingelheim, December, Hartford, CT.
“Human Relevance of Rodent Liver Tumors”, Health and Environmental Science Institute Annual
Meeting, January, New Orleans, LA
“Environmental Carcinogenesis”, School of Public and Environmental Affairs at Indiana
University, February, Bloomington, Indiana
Merck Lecture “Mechanisms of Liver Carcinogenesis”, Department of Pathology, College of
Veterinary Medicine, University of Illinois, May, Champaign –Urbana, IL
“Understanding the Mode of Action Approach used by the US EPA Human Health
Assessment Group”, November, Dow Agro Sciences, Indianapolis, IN
“Mode of Action of Acrylonitrile”, February, The Toxicology Forum Annual Meeting,
Washington, DC
Chairman, Society of Toxicology Annual Meeting, March, Symposium “Role of the Kupffer Cell
in Mediating Hepatic Toxicity and Carcinogenesis”
“Health Effects of Algal Toxins”, April, Emerging Issues in Source Water Management and
Strategies for Addressing New Drinking Water Regulations Conference, IUPUI
Indianapolis, Indiana
“Oxidative Stress and Cancer”, June, Indiana University Cancer Center Grand Rounds, IUPUI
Indianapolis, Indiana
“Mechanisms of Cancer and Chemoprevention”, September, Indiana University and Purdue
University Retreat on Cancer Prevention and Control, West Lafayette, Indiana
“Mechanisms of Hepatic Carcinogenesis”, September, Tenth Annual John Doull Toxicology
Symposia, Kansas University Medical Center, Kansas City, Kansas.
“PPAR Agonist Project Committee Report”, January, 2007 HESI Annual Meeting, Cancun,
Mexico.
“Perchloroethylene (PERC): Mouse Liver Tumors and PPAR Alpha-related Responses Relevance
for Man”, January, 32nd Annual Winter Meeting of the Toxicology Forum, Washington,
DC.
“Mechanisms of Cancer Chemoprevention: Studies with Green and Black Tea,” March, Bindley
Oncological Science Center, Purdue University, Lafayette, Indiana
“Mechanisms of Cancer Chemoprevention: Relevance to Human Risk assessment,” March,
46th Annual Society of Toxicology, Charlotte, North Carolina
“Endocrine Disruptors and their effect on Children’s Health” April, 2007 Summit on Children’s
Health and the Environment, Indiana University, Indianapolis, Indiana.
“Oxidative Stress as a Mechanism of Carcinogenicity,” May, AN Group, Alexandria, Virginia
“Oxidative Stress as a Common Event in Rodent Hepatic Carcinogenesis,” July, International
Congress of Toxicology, Montreal, Canada
“Chemistry and Toxicology of Acrylamide,” August, American Chemistry Society Annual
Meeting, Boston, Massachusetts
“Pharmacology and Toxicology – Prosecution of Operating While Intoxicated”, September, Trial
Advocacy Course, Indiana Prosecuting Attorneys Council, Indianapolis, Indiana
“Application of Mode of Action and the Human Relevance Framework for Hepatocellular
Neoplasms”, September, Joint European Congress of Toxicologic Pathology and
International Federation of Societies of Toxicologic Pathologists Congress of
Toxicologic Pathology 2007, Basel,
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2007
2007
2007
2007
2007
2007
2009
2010
2008
2008
2008
2008
2009
2009
2009
2009
2009
2009
2010
2011
2012
2012
2012
2013
2013
Switzerland
“Cell Death in Response to Toxicants: Role of Cellular Environment: Kupffer Cells and the
Hepatic Response to Toxicants”, October, Eurotox 2007, Amsterdam, Netherlands.
“Toxicology of Veterinary Oncology”, October, Veterinary Oncology Models Platform,
Biocrossroads Fairbanks Foundation Initiative, West Lafayette, Indiana.
“Oxidative Damage in Cancer”, November, Cancer Prevention, Chemoprevention and Control 2 nd
Annual Faculty Retreat, West Lafayette, Indiana.
“Application of the Human Relevance Framework to the Analysis of Rodent Tumor Data”
November, American College of Toxicology Meeting, Charlotte, North Carolina.
“PPAR Alpha Agonist and Hepatic Cancer: Overview of Mode of Action in the Mouse”.
December. Society of Risk Analysis 2007 Annual Meeting. San Antonio, Texas.
Acrylonitrile’s Modes of Carcinogenic Action (MOA) in the Rat and Mouse and Their
Relevance to Human Risk Assessment, Acrylonitrile working group, Washington DC
“A Human Relevance Framework for Human Risk Assessment: A Case Study with Dioxins and
PCBs Based on Mode of Action,” January, Toxicology Forum, Washington, D.C.
“The Role of Oxidative Stress and Oxidative Damage in Chemical Carcinogenesis,” April 2008
Toxicology and Risk Assessment Conference (TRAC), Cincinnati, Ohio
“Indiana Drinking Water Quality,” March 2008, WIBC Radio Interview
“Modifiers and Modulators of Chemical Carcinogenesis.” Benjamin Trump Lecture: July 2008.
23rd Aspen Cancer Conference: Mechanisms of Toxicity, Carcinogenesis, Cancer
Prevention and Cancer Therapy. Aspen, Colorado
“Chemically Induced Brain Tumors: Role of Oxidative Stress,” November 2008, Brain Tumor
Working Group, Indiana University, Indianapolis, Indiana
“Nongenotoxic agents: studies with 2-butoxyethanol,” December 2008, Society of Toxicology
Contemporary Concepts in Toxicology (CCT) Workshop – Hemangiosarcoma in
Rodents: Mode-Of-Action Evaluation and Human Relevance, Arlington, Virginia
“Multistage hepatic carcinogenesis: Modulators and modifiers,” February 2009, Department of
Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan
“PPAR: Relevance of rodent tumors to man.” March 2009. British Toxicology Society Annual
Congress 2009, University of Warwick, United Kingdom
“Oxidative stress/damage in carcinogenesis.” June 2009. Society of Toxicologic Pathology, 28 th
Annual Symposium, Washington, D.C.
Hemangiosarcomas in Rodents – Relevance to Humans?” July 2009. Toxicology Forum, Aspen,
Colorado.
“Implication of Recent Data on Benzene Risk Assessment. Weight of Evidence for Mode of
Action/Human Relevance and Dose-Response.” September 2009. Benzene 2009:
Health Effects and Mechanisms of Bone Marrow Toxicity Implications for t-AML and
the Mode of Action Framework, Munich, Germany.
Genotoxicity and Carcinogenicity of Acrylamide.” September 2009. EUROTOX: 46th Congress
of the European Societies of Toxicology, Dresden, Germany.
A Human Relevance Framework for Human Risk Assessment: A Case Study with Dioxins and
PCBs Based on Mode of Action,” January, Toxicology Forum, Washington, D.C.
“The Role of Oxidative Stress and Oxidative Damage in Chemical Carcinogenesis,” April 2011
Toxicology and Risk Assessment Conference (TRAC), Cincinnati, Ohio.
Oxidative Stress in Toxicology June 2012 Annual Symposium of Meeting of Society of
Toxicological Pathology, Boston, MA.
Epidemiology, toxicology and risk assessment, September 2012. HESI. Evaluating Causality in
Epidemiologic Studies Workshop, USEPA RTP NC.
Current Understanding of the Mode of Action of Non-genotoxic Hepatocarcinogens." October,
CRX Biosciences Symposium, Cambridge, MA.
“Toxicology and Evidentiary Issues in Impaired Driving Cases.” July. American Bar Association,
Webinar.
“Adverse Versus Adaptive Effects in Toxicology; Implications for Human Risk.” 39 th Annual
Summer Meeting of The Toxicology Forum, Aspen, CO.
53
RESEARCH INTERESTS:
Environmental Toxicology and Carcinogenesis
Mechanisms of Cellular Toxicology and Pathology
Liver Toxicology and Carcinogenesis
Role of Free Radical Oxygen Species and Oxidative Stress in Toxicology and Carcinogenesis
Role of Gap Junction Mediated Intercellular Communication in Hepatic Toxicity and Carcinogenesis
Role of Cell Proliferation and Growth Factors in Hepatic Tumorigenesis
Cancer Chemoprevention
Effects of Alcohol and Drugs on Impaired Driving
High throughput toxicological evaluation
54