Molecular Structure of Amino Acids Schatzi Sovich Ventura High School July 2005 Introduction: This activity is designed to introduce amino acids. Students will use internet websites to read and answer questions, and use molecular visualization sites to analyze amino acids in a three dimensional manner. To view the 3-D image your Netscape browser must have the Chemscape Chime Plugin. Purpose: To cover California Science Standards for Biology/Life Science sections: http://www.cde.ca.gov/be/st/ss/scmain.asp Cell Biology 1 d,e,h Genetics 4 a-f, 5a-b Grade Level: Chemistry, Biology, Physiology Grades 10-12 Procedure: 1. Go to http://www.chem4kids.com/ 2. Click on Biochemistry: Read the text and answer question #1. 3. Click on Amino Acid Structure. Read the text and answer questions #2-8. 4. Scroll back up and click on Essential Amino Acids. Click on each of the amino acids and begin the amino acid table. 5. Go to http://iws.ohiolink.edu/chemistry/biochemistry/aatut.html to analyze the amino acid molecules and complete the amino acid table. Gray = Carbon White = Hydrogen Red = Oxygen Blue = Nitrogen Sulfur = Yellow 6. Go to Amino Acid ID Quiz http://www.bio.cmu.edu/Courses/BiochemMols/aaIDCQz/aaQCMain.htm 7. Take the quiz and write your results on question #10. Questions: 1. What is biochemistry? 2. What is an amino acid? 3. How many amino acids are there? 4. Name some uses of proteins? 5. Draw the amino acid in the yellow box. Circle the carboxyl group and the amino group and the side group. 6. Why is the carboxyl group negatively charged and the amine group positively charged? 7. What are the side groups and why are they important? 8. Name and describe three types of side groups. Amino Acids Animo Acid Alanine Arginine Asparagine Aspartic Acid Cysteine Glutamic Acid Glutamine Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Symbol Structural Formula Type % in Proteins Proline Serine Threonine Tryptophan Tyrosine Valine #10 Quiz: (Name the Amino Acid) 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. Useful Websites: Amino Acid ID Quiz: http://www.bio.cmu.edu/Courses/BiochemMols/aaIDCQz/aaQCMain.htm Amino Acid Structures: http://www.clunet.edu/BioDev/omm/aa/aa.htm Amino Acid Tutorial: http://iws.ohiolink.edu/chemistry/biochemistry/aatut.html Chemistry for Kids: http://www.chem4kids.com/map.html California Science Standards: http://www.cde.ca.gov/be/st/ss/scmain.asp Chemistry Molecular Models: http://www.uwsp.edu/chemistry/pdbs/#AMINO%20ACIDS DNA structure: http://molvis.sdsc.edu/dna/index.htm DNA from the beginnings: http://www.dnaftb.org/dnaftb/ DNA structure: http://molvis.sdsc.edu/dna/index.htm Exploring DNA: http://www2.mrc-lmb.cam.ac.uk/DNA/index.html Hemoglobin Tutorial: http://www.umass.edu/microbio/chime/hemoglob/2frmcont.htm ***Molecular Biology Notebook: http://www.rothamsted.bbsrc.ac.uk/notebook/courses/guide/prot.htm Molecular Models for Biochemistry: http://info.bio.cmu.edu/Courses/BiochemMols/BCMolecules.html Molecular Visualization: http://www.clunet.edu/BioDev/marcey/assi/molvis_05.htm Molecular Visualization Resources: http://www.umass.edu/microbio/chime/ Molecules: http://www.molecules.org/ Protein Data Bank: http://rutgers.rcsb.org/pdb/ Protein structure & diversity: http://www.rothamsted.bbsrc.ac.uk/notebook/courses/guide/prot.htm Protein Synthesis Tutorial: http://www.massey.ac.nz/~wwbioch/Prot/tutehome/tutepage.htm Review of Amino Acids: http://wbiomed.curtin.edu.au/teach/biochem/tutorials/AAs/AA.html Science Odyssey: http://www.pbs.org/wgbh/aso/ Side by Side Amino Acid Viewer: http://info.bio.cmu.edu/Courses/BiochemMols/AAViewer/AAVFrameset.htm