CURRICULUM VITAE: Amir Z. Maksyutov
Name:
Amir Z. Maksyutov
Date of birth:
August 10, 1954
Marital status:
married, four children
Home Address:
Koltsovo, 12, apt. 27, Novosibirsk region, 630559, RUSSIA
Business Address:
SRC VB VECTOR, Koltsovo, Novosibirsk region, 630559, RUSSIA
Phone:
+7 3832 366 479
Fax:
+7 3832 367 409
E-mail:
maksyutov@vector.nsc.ru
Institutional affiliation:
Leading Scientist, Research Institute of Molecular Biology, State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Novosibirsk region, 630559, RUSSIA
Educational history:
From 1971 to 1976 - student of Novosibirsk State University, Department of Mathematics, Novosibirsk, Russia; field of study - mathematical
logic; the title of the thesis - "About creation of recursively enumerable sets";
the name of the research adviser - Dmitrii A. Zakharov, Ph.D., Professor
Title of the Ph.D. thesis: "Theoretical Analysis of Antigenic and Immunochemical Properties of Proteins"; degree of Candidate of Biological Sciences
(Ph.D) was awarded in 1990 after maintenance of this thesis in Research Institute of Molecular Biology, State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Novosibirsk region, Russia; the name of the
research adviser - Vladimir A. Kulichkov, Ph.D
Research positions: Since 1976 - researcher of the Theoretical Department of the Research Institute of Molecular Biology, State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Novosibirsk region, Russia:

at first - Junior Scientist,

since 1990 - Senior Scientist,

since 1998 - Leading Scientist
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CURRICULUM VITAE: Amir Z. Maksyutov
THE SUMMARY OF CURRENT RESEARCH INTERESTS AND ACHIEVEMENTS:
 Studies aimed at the development of vaccines of a new generation against complex infectious agents in the first place against highly variable infectious agents that may challenge
public health or be weapons of bioterrorism.
 Development of candidate vaccines of a new generation for prevention and treatment of infectious diseases called by highly variable infectious agents (HIV/AIDS, hepatitis C, influenza, malaria, tuberculosis, etc.), which capable of eliciting a protective immune response
to a broad range of strains of a variable infectious agent, both those that existed in the past
or currently exist and those that may arise in the human population in future.
 Development of candidate vaccines of a new generation for prevention and treatment of infectious diseases called by complex infectious agents that may challenge public health or be
weapons of bioterrorism (SARS-associated coronaviruses, smallpox, Marburg, Ebola, tickborne encephalitis virus, some types of cancer, etc.).
 Theoretical analysis and prediction of protein antigenic determinants for B-cell and T-cell
immune response.
 Design of artificial antigens for mimicking of antigenic portraits of complex antigens (viruses, microorganisms) by means of using of libraries of artificial chimeric proteins and
peptides.
 The approach is based on our own patent method of modeling the prevailing general antigenic portrait of complex variable antigens with the use of a representative set of chimeric
antigenic peptides. It was applied to designing a candidate vaccine against a broad range of
HIV-1 variants. The pilot version of the candidate HIV-1 vaccine elicited the humoral and
cell-mediated immune responses to a broad range of HIV-1 variants. Using this approach
allows induction of a broad range of antibodies, the cumulative specificity of which would
cover the diversity of a variable infectious agent strains of various subtypes, both currently
existing and those that may arise in the human population in the future.
 Design and development of chimeric antigens of a new generation for diagnostic kits. Applications: HIV, HCV, Treponema pallidum, etc.
 Theoretical estimation of antigenic cross-reactivity of proteins and peptides. Theoretical
analysis of molecular mimicry between viral proteins and host cell proteins as a cause of virus-induced autoimmunity.
 Theoretical analysis of structure-functional organization of proteins. Selection of regions
on protein carriers where replacements/insertions of some antigenic (or possessing other
characteristics) amino acid sequence portions could be made. Applications: theoretical
analysis of possible antigenic variability of viral glycoprotein.
 Design of chymeric proteins and peptides. Applications: stabilization of gamma-interferon
to denaturation by introducing of amino acid substitutions; design of a synthetic receptor
binding region of the human insulin.
 Development of computer software. I have developed the following computer packages:
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CURRICULUM VITAE: Amir Z. Maksyutov
o For conformational analysis and modeling of molecular dynamics of proteins and
peptides.
o For protein structure visualization.
o For prediction of protein antigenic determinants for B-cell and T-cell immune response.
o For calculation of cross-reaction between the homologous proteins, viral glycoproteins on the base of original theoretical method.
o For search local similarities between protein sequences.
o Reference system containing description of principles of epitope organisation and
mechanisms of B-cell and T-cell immune response.
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CURRICULUM VITAE: Amir Z. Maksyutov
BIBLIOGRAPHY (100 scientific publications), some of them:
1.
Maksyutov, A.Z., Zagrebelnaya, E.S. ADEPT: a Computer Program for Prediction of Protein
Antigenic Determinants. // Computer Applic. in the Biosciences, 1993, Vol. 9, No. 3, P. 291297.
2.
Maksyutov, A.Z., Zagrebelny, S.N. Antigenic Determinants of Proteins. Humoral Immune
Response (A Review). // Molecular Biology (Russian), 1993, Vol. 27, No. 5, part 1, P. 603610.
3.
Maksyutov, A.Z. Theoretical design of new antiinfluenza drift-steady polypeptide vaccines
on the base of some surface regions of hemagglutinin molecule that were conserved in the
course of evolution. // Abstracts of the Fourteenth American Peptide Symposium (Columbus,
Ohio, June 18-23, 1995). The Ohio State University, Ohio, 1995. P. 2-184.
4.
Maksyutov, A.Z., Eroshkin, A.M., Kulichkov, V.A. Method for calculating immunochemical
cross-reaction between homologous proteins. // Molecular Biology (Russian), 1987, Vol. 21,
No. 1, P. 30-37.
5.
Maksyutov, A.Z. Correlation of the antigenic properties of influenza subtype H3N2 viruses
with amino acid substitutions in hemagglutinin. // Voprosy virusologii (Russian), 1989, No.
3, P. 283-288.
6.
Gaidamovich, S.Ya., Loktev, V.B., Lavrova, N.A., Maksyutov, A.Z., Melnikova, E.E., Pereboev, A.V., Protopopova, E.V., Razumov, I.A., Sveshnikova, N.A., Khusainova, A.D.
Monoclonal antibodies cross-reacting with tick-borne encephalitis and venezuelan equine encephalomyelitis viruses. // Voprosy virusologii (Russian), 1990, No. 3, P. 221-225.
7.
Maksyutov, A.Z., Onishchenko, A.M. The system of molecular diagnostics and prophylaxis
of foot-and-mouth disease virus. // Abstracts of the Third International Congress of Veterinary Virology "Immunobiology of Viral Infections" (Interlaken, Switzerland, Sept. 4-7,
1994). Switzerland, 1994. P. 9-12.
8.
Maksyutov, A.Z., Onishchenko, A.M. Mathematical model for the estimation of the antigenic
cross-reaction of FMD viruses. // Abstracts of International conference "To the new strategy
for FMD control" (Suzdal, Oct. 26-31, 1991). Vladimir, 1991. P. 129-134.
9.
Maksyutov, A.Z. Development of principally new stable to drift polypeptide vaccines on the
basis of conservative surface regions mimicking space structure of proteins of FMDV coating. // Ibid, P. 134-136.
10.
Ilyichev, A.A., Melamed, N.V., Razumov, I.A., Maksyutov, A.Z., Pereboev, A.V., Zakabunin, A.I., Loktev, V.B. Expression of gene fragments for the E2 protein of Venezuelan equine
encephalomyelitis virus in a phage T7 RNA polymerase-based system. // Molecular Biology
(Russian), 1996, Vol. 30, No. 1, Part 1, P. 46-50.
11.
Kuvshinov, V.N., Kuzmicheva, G.A., Masycheva, V.I., Maksyutov, A.Z. et al. On the capacity of recombinant protein containing fragment 114-122 of myelin basic protein to induce
allergic encephalomyelitis in guinea pigs. // Molecular genetics, microbiology and virology
(Russian), 1996, No. 2, P. 18-22.
12.
Kanev, A.N., Vorob'eva, M.S., Shalunova, N.V., Pereboeva, l.A., Maksyutov, A.Z., Kiselev,
N.N., Shalaev, E.Yu., Yastrebova, O.N., Varaksin, N.A. Design of the Reference panels of
sera with normalized level of IgG antibodies. // Voprosy virusologii (Russian), 1996, No. 4,
P. 161-166.
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CURRICULUM VITAE: Amir Z. Maksyutov
13.
Panin, L.E., Maksyutov, A.Z., Poteryaeva, O.N., Polyakov, L.M. Immunochemical analysis
of a supposed receptor binding region of the human insulin. // Proc. of Russian Academy of
Sci., 1996, Vol. 349, No. 2, P. 262-264.
14.
Panin, L.E., Sabirov, A.N., Maksyutov, A.Z., Poteryaeva, O.N., Polyakov, L.M. Design, synthesis and immunochemical analysis of a supposed receptor binding region of the human insulin. // Molecular Biology (Russian), 1997, Vol. 31, No. 2, P. 366-372.
15.
Kanev, A.N., Vorob'eva, M.S., Lomanova, G.A., Maksyutov, A.Z., Gutova, E.A. Development of serum panels for assessing the quality of screening for anti-HIV antibodies in practical laboratories. // Voprosy virusologii (Russian), 1997, No. 6, P. 275-280.
16.
Panin, L.E., Tusikov, F.V., Poteryaeva, O.N., Maksyutov, A.Z., Tusikova, N.A., Sabirov,
A.N. The Synthesis of Insulin Fragments and the Study of Their Physicochemical and Immune
Properties. // Bioorganic Chemistry (Russian), 1997, Vol. 23, No. 12, P. 953-960.
17.
Kanev, A.N., Vorob'eva, M.S., Shalunova, N.V., Karpovich, L.G., Netesov, S.V., Maksyutov,
A.Z., Usova, S.V. Development of reference panels of sera for quality control ELISA kits in
Russia. // Bulletin of Russian Acad. Med. Sci. (Russian). 1998. №. 3. P. 47-52.
18.
Perminova, N.G., Timofeev, I.V., Paletskaya, T.F., Maksyutov, A.Z., Kozhina, E.M. Human
Herpesvirus-6 (HHV-6): current status. // Bulletin of Russian Acad. Med. Sci. (Russian).
1998. №. 4. P. 21-24.
19.
Maksyutov, A. Z., Timofeev, I. V., and Perminova, N. G. Strategy for development of
HIV/AIDS vaccines based on HIV diversity. Russian Journal of HIV/AIDS and Related Problems. 1999. 3(1), 147-148.
20.
Shustov, A.V., Maksyutov, A.Z., Kisselev, N.N., Mishin, V.P., Tolokonskaya, N.P., Robertson, B.D., Netesov, S.V. Prevalence of hepatitis C virus infection markers and its genotypes
among patients of the 1-st Municipal Infectious Disease Clinical Hospital of Novosibirsk. //
Voprosy virusologii (Russian). 2000. №6. P. 22-27.
21.
Maksyutov A.Z., Bachinsky A.G., Chepurnov A.A. Searching for local similarities between
viral and human proteins revealed Ebola virus potential virulence factors. // The Infectious
Disease Review. 2001. July. Suppl. 3. P. 105-112.
22.
Maksyutov A. Z., Bachinsky A. G., Bazhan, S. I. Searching for Local Similarities between
HIV-1 and Human Proteins. Application to Vaccines. // Molecular Biology, 2002, 36(3), 346358.
23.
Maksyutov A.Z., Kolobov A.A., Ryzhikov A.B., Ryzhikov E.A., Maksyutov Z.A., Maksyutova A.V., Kanev A.N., Kampe-Nemm E.A., Shpen V.M., Prusakov A.N., Goncharova E.P.,
Bulychev L.E., Poryvaev V.D., Sizov A.A., Lebedev L.R., Sizikova T.A., Markham R.B.
Candidate vaccine capable of eliciting protective humoral and cell-mediated responses to
broad range of HIV-1 variants. // Abstracts of the Sixth International Forum on Global Vaccinology “Vaccines and Immunization” (Minsk, Belarus, September 25-26, 2003). P. 21.
24.
Maksyutov A.Z., Ryzhikov E.A., Goncharova E.P., Poryvaev V.D., Bulychev L.E., Karpyshev
N.N., Samukov V.V., Ryzhikov A.B. Theoretical design and immunogenic properties of antiTBEV peptide vaccine candidate. // Abstracts of the Sixth International Forum on Global
Vaccinology “Vaccines and Immunization” (Minsk, Belarus, September 25-26, 2003). P. 34.
25.
Maksyutov Z.A., Maksyutov A. Z. (2003). Prediction of protein antigenic determinants. //
Russian Journal of HIV/AIDS and Related Problems 7(2), 64.
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CURRICULUM VITAE: Amir Z. Maksyutov
26.
Maksyutov A.Z., Bachinskii A.G., Bazhan S.I., Ryzhikov E.A. Design of Safe AIDS Vaccines Based on Search for Local Similarities between HIV-1 and Human Proteins. // In: AIDS
Vaccines and Related Topics (Bourinbaiar AS, Ed.), Research Signpost, Kerala, India. 2004.
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