Cardiac Status Grading Criteria As currently used in MCC-8631 and others: New York Heart Association Classification of Heart Failure Class I No symptoms. Ordinary physical activity such as walking and climbing stairs does not cause fatigue or dyspnea. Class II Symptoms with ordinary physical activity. Walking or climbing stairs rapidly, walking uphill, walking or stair climbing after meals, in cold weather, in wind or when under emotional stress causes undue fatigue or dyspnea. Class III Symptoms with less than ordinary physical activity. Walking one to two blocks on the level and climbing more than one flight of stairs in normal conditions causes undue fatigue or dyspnea. Class IV Symptoms at rest. Inability to carry on any physical activity without fatigue or dyspnea. Taken directly from the reference: NYHA Functional Capacity Assessment of Cardiac Status (Dolgin et al., 1994) Class Description I Patients with cardiac disease but without resulting limitation of physical activity. Ordinary physical activity does not cause undue fatigue, palpitation, dyspnea, or anginal pain. II Patients with cardiac disease resulting in slight limitation of physical activity. They are comfortable at rest. Ordinary physical activity results in fatigue, palpitation, dyspnea, or anginal pain. III Patients with marked limitation of physical activity. They are comfortable at rest. Less than ordinary activity causes fatigue, palpitation, dyspnea, or anginal pain. IV Patients with cardiac disease resulting in inability to carry on any physical activity without discomfort. Symptoms of heart failure or of the anginal syndrome may be present even at rest. If any physical activity is undertaken, discomfort is increased. 1 NYHA Objective Assessment of Cardiac Status (Dolgin et al., 1994) Grade Description A No objective evidence of cardiovascular disease. B Objective evidence of minimal cardiovascular disease. C Objective evidence of moderately severe cardiovascular disease. D Objective evidence of severe cardiovascular disease. Dolgin, M., Fox, A.C., Gorlin, R., and Levin, R.I. (1994). Nomenclature and Criteria for Diagnosis of Diseases of the Heart and Great Vessels, 9 edn (Boston, Little, Brown and Company). 2