Work Programme extract Fundamental knowledge and basic tools for functional genomics in all organisms 1.1.3 Comparative genomics and population genetics The objectives are to enable researchers to use well-characterised model organisms for predicting and testing gene function and to take full advantage of specific population cohorts available in Europe to determine the relationship between gene function and health or disease. Topics for fourth call, deadline 9 November 2005: LSH-2005-1.1.3-1: Functional genomics in Arabidopsis thaliana - INTEGRATED PROJECT. The research should focus on systematic multidisciplinary approaches to reveal and characterise functional interactions in Arabidopsis thaliana (such as protein/protein interactions, functional modules and regulatory networks). Tools, data and resources developed during the project should be made readily accessible to the scientific community. LSH-2005-1.1.3-2: High throughput phenotyping tools and approaches for large scale functional genomics studies – INTEGRATED PROJECT. The focus should be on standardising, developing new or improving existing phenotyping tools, approaches and technologies for high throughput phenotyping in a given model organism. The research and data storage should link with existing bioinformatics resources, including annotated databases. LSH-2005-1.1.3-3: Population cohorts for molecular epidemiological studies in European and other populations – INTEGRATED PROJECT. The focus should be on molecular epidemiological studies using well characterised and comprehensive population cohorts, with an emphasis on standardising genotyping protocols, sample collection and data storage and analysis. The project should focus on generating new knowledge relevant to health and disease.