Principal Investigator/ Program Director: Emch, Michael, Edward
B. Selected Publications (of approximately 150)
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Breiman RF, Horwitz MA. Guinea pigs sublethally infected with aerosolized
Legionella pneumophila develop humoral and cell-mediated immune responses
and are protected against lethal challenge; A model for studying host defense
against lung infections caused by intracellular pathogens. J Exp Med
1987;164:799-811.
Breiman RF, Silverblatt FJ. Systemic Streptococcus equi infection in a horse
handler: A case of human strangles. West J Med 1986;145:385-386.
Breiman RF, Spika JS, Navarro VC, Darden PM, Darby CP. Pneumococcal
bacteremia in Charleston County: A decade later. Arch Intern Med.
1990;150:1401-5.
Breiman RF, Cozen W, Fields BS, Mastro T, Carr SJ, Mascola L, Spika JS. Air
sampling complements epidemiologic and laboratory studies to identify the
source of a Legionnaires' disease epidemic and estimates the infectious dose of
Legionella pneumophila. J Infect Dis. 1990;161:1257-61..
Breiman RF, Fields BS, Spika JS, Sanden G, Volmer L, Meier A, Bonrud PA,
Plikaytis B, Barbaree JM. An outbreak of Legionnaires' disease associated with
shower use; possible role of amoebae. JAMA. 1990;263:2924-6.
Breiman RF, Fields BS, Sanden GN, Barbaree JM. Air sampling for Legionella.
JAMA. 1990;264:2626.
Breiman RF, Butler JC, Tenover FC, Elliott JE, Facklam RR. Emergence of
drug resistant pneumococcal infections in the United States. JAMA.
1994;271:1831-5.
Breiman RF. Impact of technology on the emergence of infectious diseases.
Epidem Rev 1996;18:4-9.
Breiman RF. Prevention of pneumococcal disease--A new romance begins. Clin
Infect Dis 1998;26:1124-1126.
Breiman RF, Butler JC. Legionnaires’ disease: Clinical, epidemiological, and
public health perspectives. Sem Resp Inf 1998;13:84-89.
Breiman RF. Book Review: The politics of international health: The Children’s
Vaccine Initiative and the struggle to develop vaccines for the third world-William Muraskin. New Engl J Med 1999;340:1373.
Breiman RF, Butler JC, McInnes PM. Vaccines to prevent respiratory infection:
Opportunities on the near and far horizon. Curr Opin Infect Dis 1999;12:145152.
Breiman RF, Ginsberg AM. An overview of the Proceedings of the International
Symposium on tuberculosis vaccine development and evaluation: Recognizing
and addressing the barriers. Clin Infect Dis 2000;30(Suppl 3):S199-200.
Breiman RF, Keller DW, Phelan MA, Sniadack DH, Stephens DS, Rimland D,
Farley MM, Schuchat A, Reingold AL Evaluation of effectiveness of the 23valent pneumococcal capsular polysaccharide vaccine for HIV-infected patients.
Arch Intern Med. 2000;160:2633-8.
Breiman RF. Vaccines as Tools for Advancing More than Public Health:
Perspectives of a former Director of the National Vaccine Program Office.
Clin Infect Dis 2001; 32:283-288.
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Principal Investigator/ Program Director: Emch, Michael, Edward
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Kombo LA, Gerber MA, Pickering LK, Atreya CD, Breiman RF.
Intussusception, infection, and immunization: summary of a workshop on
rotavirus. Pediatrics. 2001;108(2):E37.
Moroney JF, Fiore AE, Harrison LH, Patterson JE, Farley MM, Jorgensen JH,
Phelan M, Facklam RR, Cetron MS, Breiman RF, Kolczak M, Schuchat A.
Clinical outcomes of bacteremic pneumococcal pneumonia in the era of antibiotic
resistance. Clin Infect Dis. 2001;33:797-805.
Feikin DR, Elie CM, Goetz MB, Lennox JL, Carlone GM, Romero-Steiner S,
Holder PF, O'Brien WA, Whitney CG, Butler JC, Breiman RF. Randomized trial
of the quantitative and functional antibody responses to a 7-valent pneumococcal
conjugate vaccine and/or 23-valent polysaccharide vaccine among HIV-infected
adults. Vaccine. 2001;20:545-53.
Postema AS, Myers MG, Breiman RF. Challenges in the development, licensure,
and use of combination vaccines. Clin Infect Dis 2001;33:S261-S266.
Rahman M, Rahman K, Siddique AK, Shoma S, Kamal AHM, Ali KS, Nisaluk A,
Breiman RF. First outbreak of dengue hemorrhagic fever, Bangladesh. Emerg
Infect Dis J 2002;8:738-40.
Goetz MB, Feikin DR, Lennox JL, O’Brien WA, Elie CM, Butler JC, Breiman
RF. Viral load response to a 7-valent pneumococcal conjugate vaccine,
polysaccharide vaccine or placebo among HIV-infected patients. AIDS
2002;16:1421-23.
Breiman RF, Evans MR, Preiser W, et al. Role of China in the quest to define
and control Severe Acute Respiratory Syndrome. Emerg Infect Dis 2003;9:103741.
Hossain AM, Khatun M, Arjumand F, Nisaluk A, Breiman RF. Serologic
evidence of dengue illness before onset of dengue epidemic, Bangladesh. Emerg
Infect Dis 2003;9:1411-1414.
Plouffe JF, Breiman RF, Fields BS, et al. Azithromycin in the treatment of
Legionella pneumonia requiring hospitalization. Clin Infect Dis. In press.
Ali M, Wagatsuma Y, Emch M, Breiman RF. Defining spatial risk for dengue
transmission in Bangladesh using a geographic information system. Am J Trop
Med Hyg. In press.
C. Research Support
 No U.S. federal grants in past 3-years
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